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PPP1R3A Gene

protein-coding   GIFtS: 59
GCID: GC07M113516

Protein Phosphatase 1, Regulatory Subunit 3A

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 3A...)
(Previous symbol: PPP1R3)
  See PPP1R3A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 3A1 2     RG12 3
PPP1R31 2 5     Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3A (Glycogen And
Sarcoplasmic Reticulum Binding Subunit, Skeletal Muscle)1
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3A1 2     GM2
Glycogen-Associated Regulatory Subunit Of Protein Phosphatase-11 2     Glycogen And Sarcoplasmic Reticulum Binding Subunit, Skeletal Muscle2
Protein Phosphatase 1 Regulatory Subunit GM1 2     Protein Phosphatase 1 Glycogen- Associated Regulatory Subunit2
Protein Phosphatase 1 Glycogen-Associated Regulatory Subunit2 3     Protein Phosphatase 1 Regulatory Subunit 3A2
Protein Phosphatase Type-1 Glycogen Targeting Subunit2 3     Serine /Threonine Specific Protein Phosphatase2
PP1G2 3     Type-1 Protein Phosphatase Skeletal Muscle Glycogen Targeting Subunit2

External Ids:    HGNC: 92911   Entrez Gene: 55062   Ensembl: ENSG000001544157   OMIM: 6009175   UniProtKB: Q168213   

Export aliases for PPP1R3A gene to outside databases

Previous GC identifers: GC07M111992 GC07M113055 GC07M113068 GC07M113108 GC07M113301 GC07M107880


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R3A Gene:
The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed
of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory
subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound
substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1R3A Gene:
PPP1R3A (protein phosphatase 1, regulatory subunit 3A) is a protein-coding gene. Diseases associated with PPP1R3A include insulin resistance, severe, digenic, and rippling muscle disease. An important paralog of this gene is PPP1R3G.

UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821
Function: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and
participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an
important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By
similarity)

Gene Wiki entry for PPP1R3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R3A gene promoter:
         AML1a   RelA   CUTL1   NF-kappaB   Evi-1   E47   POU2F1   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R3A promoter sequence
   Search Chromatin IP Primers for PPP1R3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1

PPP1R3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R3A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M113516:  view genomic region     (about GC identifiers)

Start:
113,516,832 bp from pter      End:
113,715,975 bp from pter
Size:
199,144 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 112,912,237-112,954,446     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 3A  
Size: 1122 amino acids; 125767 Da
Subunit: Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen (By similarity)
Sequence caution: Sequence=AAS07492.1; Type=Erroneous gene model prediction;
Secondary accessions: A0AVQ2 A4D0T6 O43476 Q75LN8 Q7KYM8 Q86UI6
Alternative splicing: 2 isoforms:  Q16821-1   Q16821-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PPP1R3A: NX_Q16821

Explore proteomics data for PPP1R3A at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase
    (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002702.2  
    ENSEMBL proteins: 
     ENSP00000284601   ENSP00000401278   ENSP00000284602  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR005036 CBM_21

    Graphical View of Domain Structure for InterPro Entry Q16821

    ProtoNet protein and cluster: Q16821

    1 Blocks protein domain: IPB005036 Putative phosphatase regulatory subunit

    UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821
    Domain: The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some
    regulatory subunit of phosphatase complexes
    Similarity: Contains 1 CBM21 (carbohydrate binding type-21) domain


    Find genes that share domains with PPP1R3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPR3A_HUMAN, Q16821
    Function: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and
    participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an
    important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PPP1R3A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP1R3A:
     Apoptosis resistance 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppp1r3a):
     adipose tissue  growth/size/body  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with PPP1R3A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PPP1R3A: Ppp1r3atm1Adpr Ppp1r3atm1Ptwc

       genOway: Develop your customized and physiologically relevant rodent model for PPP1R3A

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    SwitchGear 3'UTR luciferase reporter plasmidPPP1R3A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPR3A_HUMAN, Q16821: Membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PPP1R3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R3A About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    4PEDF Induced Signaling
    IL-6 Pathway0.61
    5ERK Signaling
    ERK Signaling0.61


    Find genes that share SuperPaths with PPP1R3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R3A (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R3A
        Insulin Pathway

    1 GeneGo (Thomson Reuters) Pathway for PPP1R3A
        Regulation of lipid metabolism Insulin signaling-generic cascades

    2 BioSystems Pathways for PPP1R3A
        Insulin Signaling
    Insulin-mediated glucose transport


    1 Kegg Pathway  (Kegg details for PPP1R3A):
        Insulin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP1R3A
    Interactions:

        GeneGlobe Interaction Network for PPP1R3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1R3A (Q168213 ENSP000002846014) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLNP266783, ENSP000003501324I2D: score=2 STRING: ENSP00000350132
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    RPS6KA1Q154183, ENSP000003632774I2D: score=1 STRING: ENSP00000363277
    CSF1P096033I2D: score=1 
    GSK3BENSP000003248064STRING: ENSP00000324806
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--

    Find genes that share ontologies with PPP1R3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R3A (PPR3A)

    6 Novoseek inferred chemical compound relationships for PPP1R3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 73.6 53 11361130 (3), 1651242 (2), 12606498 (2), 10907117 (2) (see all 18)
    glucose 45.3 5 14694850 (1), 9814479 (1), 10868947 (1), 10907117 (1)
    2-deoxyglucose 35.2 1 10907117 (1)
    glucose 6-phosphate 27.7 2 9148744 (1)
    epinephrine 7.34 1 1651242 (1)
    lipid 0 1 12118251 (1)



    Find genes that share compounds with PPP1R3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1R3A gene: 
    NM_002711.3  

    Unigene Cluster for PPP1R3A:

    Protein phosphatase 1, regulatory subunit 3A
    Hs.458309  [show with all ESTs]
    Unigene Representative Sequence: X78578
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284601(uc010ljy.1) ENST00000449795 ENST00000284602
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    Additional mRNA sequence: 

    AF024579.1 BC017405.1 BC056666.1 BC070313.1 BC126451.1 BC126453.1 X78578.1 

    3 DOTS entries:

    DT.109325  DT.91810752  DT.95320696 

    Selected AceView cDNA sequences (see all 27):

    BC056666 BX500352 AL598231 AF024579 AI336142 BF791215 BX500591 NM_002711 
    BF791239 BC070313 AL600065 BX283518 BF693530 X78578 BC017405 F00032 
    BF694832 BF576879 BF693311 BF672236 AW118744 AA176401 BG194223 BF791088 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for PPP1R3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPP1R3A Expression
    About this image

    PPP1R3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458309

    UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821
    Tissue specificity: Skeletal muscle and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R3A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r3a1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 77.31(n)1
    64.02(a)1
      6 (6.31 cM)5
    1404911  NM_080464.21  NP_536712.21 
     147138225 
    chicken
    (Gallus gallus)
    Aves PPP1R3A1 protein phosphatase 1, regulatory subunit 3A 58.8(n)
    42.04(a)
      101747406  XM_004937541.1  XP_004937598.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R3A6
    protein phosphatase 1, regulatory subunit 3A
    37(a)
    1 ↔ 1
    5(58975086-59011864)
    zebrafish
    (Danio rerio)
    Actinopterygii ppp1r3ab6
    ppp1r3aa6
    protein phosphatase 1, regulatory subunit 3Aa
    23(a)
    19(a)
    1 ↔ many
    1 ↔ many
    25(22457749-22466506) ENSDARG00000088813
    4(5961250-5969496) ENSDARG00000090468
    fruit fly
    (Drosophila melanogaster)
    Insecta Gbs-76A6
    Glycogen binding subunit 76A
    12(a)
    1 → many
    3L(19275028-19285624)
    worm
    (Caenorhabditis elegans)
    Secernentea CC8.26
    Protein CC8.2, isoform b
    24(a)
    1 → many
    IV(3645163-3648684) WBGene00016987


    ENSEMBL Gene Tree for PPP1R3A (if available)
    TreeFam Gene Tree for PPP1R3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R3A gene
    PPP1R3G2  PPP1R3B2  PPP1R3E2  PPP1R3D2  PPP1R3C2  

    Find genes that share paralogs with PPP1R3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R3A (see all 879)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354496511,2,,4
    C,FDiabetes mellitus, non-insulin-dependent (NIDDM)4 --116869414(+) CAATTG/TCCTGC 2 E A mis15Minor allele frequency- T:0.00NA EU 5849
    VAR_0362874
    A breast cancer sample4--see VAR_0362872 G A mis40--------
    rs1509657271,2
    Cuntested1116869362(+) GATTTC/TGTAGA 2 T syn10--------
    rs17999991,2,,4
    C,F,Hother1116869493(-) ACTCAG/TACACT 2 D Y mis1 ese337Minor allele frequency- N:0.00EU EA NA CA NS WA CSA 11038
    rs58866871,2
    C,F--107923444(+) TCACG-/TTTTTT 1 -- us2k1 tfbs33Minor allele frequency- T:0.33NA CSA 6
    rs58866831,2
    C--113517317(+) AATTG-/TT/   
       TTAAA
    AACAA
    2 -- ut310--------
    rs339851981,2
    C--113517318(+) ATTGA-/AAT/
     T
    /TTAAA
    ACAAA
    3 -- ut31 cds10--------
    rs58866851,2
    C,F--113520770(+) CTGTG-/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.33NA CSA 6
    rs3724828281,2
    C--113528108(+) CAAAA-/AAAAAAG 1 -- int10--------
    rs343905641,2
    C--113530135(+) TCAGT-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PPP1R3A (113516832 - 113715975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PPP1R3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv824277CNV Loss20364138
    nsv831100CNV Gain17160897
    nsv7405OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): PPP1R3A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1R3A
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600917   
    OMIM disorders: 604367  
    UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 12 diseases for PPP1R3A:    
    About MalaCards
    insulin resistance, severe, digenic    rippling muscle disease    insulin resistance    type 2 diabetes mellitus
    hypertension, insulin resistance-related    diabetes mellitus, noninsulin-dependent, late onset    diabetes mellitus, type 2, susceptiblity to    diabetes mellitus, noninsulin-dependent, 2
    diabetes mellitus, noninsulin-dependent, association with    diabetes, type 2    diabetes mellitus, noninsulin-dependent    colorectal cancer


    Find genes that share disorders with PPP1R3A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PPP1R3A gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 60.3 12 9726244 (2), 10389856 (1), 14694850 (1), 12185156 (1) (see all 9)
    niddm 45.8 8 9653600 (2), 15231141 (2), 7926294 (1), 11793847 (1) (see all 5)
    insulin sensitivity 36.7 2 10868947 (2)
    somatic mutations 30.3 5 10698503 (3)
    impaired glucose tolerance 29.2 1 10868947 (1)
    small cell lung cancer 24.2 1 10485448 (1)
    colorectal cancer 12.4 3 15870946 (2), 10485448 (1)
    nsclc 12.3 2 10485448 (1)
    ovarian cancer 8.86 1 10485448 (1)
    gastric cancer 7.66 1 10485448 (1)

    Genetic Association Database (GAD): PPP1R3A
    Human Genome Epidemiology (HuGE) Navigator: PPP1R3A (12 documents)

    Export disorders for PPP1R3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R3A gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with PPP1R3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the human glycogen-associated regulatory subunit of type I protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with non-insulin-dependent diabetes. (PubMed id 7926294)1, 2, 3, 9 Chen Y.H.... Pederson O. (Diabetes 1994)
    2. A widespread amino acid polymorphism at codon 905 of the glycogen- associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. (PubMed id 7581368)1, 2, 4 Hansen L.... Pedersen O. (Hum. Mol. Genet. 1995)
    3. PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis. (PubMed id 15870946)1, 4, 9 Hayashida Y....Yamaguchi A. (Oncol. Rep. 2005)
    4. [Study on association of PPP1R3 gene 5 bp deletion/insertion within 3'-untranslated region polymorphism with type 2 diabetes]. (PubMed id 14767904)1, 4, 9 Chen M.W....Sun H.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004)
    5. [Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province]. (PubMed id 15231141)1, 4, 9 Chen M.W....Sun H.Y. (Zhonghua Liu Xing Bing Xue Za Zhi 2004)
    6. The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. (PubMed id 11793847)1, 4, 9 Wang G....Xu X. (Chin. Med. J. 2001)
    7. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. (PubMed id 9726244)1, 2, 9 Xia J.... Prochazka M. (Diabetes 1998)
    8. Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. (PubMed id 15181086)1, 4, 9 Alcoser S.Y....Ehrmann D.A. (J. Clin. Endocrinol. Metab. 2004)
    9. Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population. (PubMed id 16276364)1, 4, 9 Pollex R.L....Hegele R.A. (Int J Obes (Lond) 2006)
    10. Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. (PubMed id 12185156)1, 4, 9 Liolitsa D....Lovestone S. (J. Neurol. Neurosurg. Psychiatr. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5506 HGNC: 9291 AceView: PPP1R3A Ensembl:ENSG00000154415 euGenes: HUgn5506
    ECgene: PPP1R3A Kegg: 5506 H-InvDB: PPP1R3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R3A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R3A gene:
    Search GeneIP for patents involving PPP1R3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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