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Aliases for PPP1R35 Gene

Aliases for PPP1R35 Gene

  • Protein Phosphatase 1 Regulatory Subunit 35 2 3 5
  • C7orf47 3 4
  • Protein Phosphatase 1, Regulatory Subunit 35 2
  • Chromosome 7 Open Reading Frame 47 2
  • UPF0683 Protein C7orf47 3

External Ids for PPP1R35 Gene

Previous HGNC Symbols for PPP1R35 Gene

  • C7orf47

Previous GeneCards Identifiers for PPP1R35 Gene

  • GC07M100034

Summaries for PPP1R35 Gene

GeneCards Summary for PPP1R35 Gene

PPP1R35 (Protein Phosphatase 1 Regulatory Subunit 35) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R35 Gene

  • Inhibits PPP1CA phosphatase activity.

Additional gene information for PPP1R35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R35 Gene

Genomics for PPP1R35 Gene

Regulatory Elements for PPP1R35 Gene

Enhancers for PPP1R35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100475 1.4 ENCODE dbSUPER 54.4 -41.1 -41140 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZSCAN25 TRIM4 GIGYF1 ZNF3 ZNF655 SRRT AP4M1 ENSG00000242798 STAG3L5P PILRA
GH07H100538 2 FANTOM5 Ensembl ENCODE dbSUPER 37.5 -108.0 -107999 12 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 SAP25 SRRT MEPCE PPP1R35 ZSCAN25 GIGYF1 AP4M1 PCOLCE-AS1 FBXO24 LRCH4
GH07H099579 1.4 FANTOM5 Ensembl ENCODE 51.8 +856.2 856215 1 ZNF2 ZBTB40 RAD21 ZNF366 ZNF354C ZNF202 ZNF680 ELF4 REST ZNF518A ZSCAN25 TRRAP TRIM4 LOC100131859 ZNF3 ZNF655 ENSG00000242798 STAG3L5P AP4M1 LOC101927550
GH07H100427 1.5 ENCODE dbSUPER 43.9 +3.4 3416 10 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZSCAN25 SRRT GIGYF1 TRIM4 AP4M1 PILRA LOC100131859 ZNF3 PPP1R35 ZSCAN21
GH07H099616 1.4 ENCODE dbSUPER 44.8 +818.3 818347 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZSCAN25 TRRAP ZNF3 AP4M1 TRIM4 ENSG00000242798 LOC100131859 LOC100419643 PPP1R35 PTCD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R35 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215791 415 1601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for PPP1R35 Gene

Chromosome:
7
Start:
100,435,277 bp from pter
End:
100,436,615 bp from pter
Size:
1,339 bases
Orientation:
Minus strand

Genomic View for PPP1R35 Gene

Genes around PPP1R35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R35 Gene

Proteins for PPP1R35 Gene

  • Protein details for PPP1R35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAP8-PPR35_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 35
    Protein Accession:
    Q8TAP8
    Secondary Accessions:
    • A4D2C5

    Protein attributes for PPP1R35 Gene

    Size:
    253 amino acids
    Molecular mass:
    27953 Da
    Quaternary structure:
    • Interacts with PPP1CA.

neXtProt entry for PPP1R35 Gene

Post-translational modifications for PPP1R35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R35 Gene

Domains & Families for PPP1R35 Gene

Gene Families for PPP1R35 Gene

Protein Domains for PPP1R35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAP8

UniProtKB/Swiss-Prot:

PPR35_HUMAN :
  • Belongs to the PPP1R35 family.
Family:
  • Belongs to the PPP1R35 family.
genes like me logo Genes that share domains with PPP1R35: view

Function for PPP1R35 Gene

Molecular function for PPP1R35 Gene

UniProtKB/Swiss-Prot Function:
Inhibits PPP1CA phosphatase activity.

Phenotypes From GWAS Catalog for PPP1R35 Gene

Gene Ontology (GO) - Molecular Function for PPP1R35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with PPP1R35: view
genes like me logo Genes that share phenotypes with PPP1R35: view

Animal Models for PPP1R35 Gene

MGI Knock Outs for PPP1R35:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPP1R35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R35 Gene

Localization for PPP1R35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R35 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R35 Gene

Pathways & Interactions for PPP1R35 Gene

SuperPathways for PPP1R35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IEA,IDA 19389623
genes like me logo Genes that share ontologies with PPP1R35: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R35 Gene

Drugs & Compounds for PPP1R35 Gene

No Compound Related Data Available

Transcripts for PPP1R35 Gene

Unigene Clusters for PPP1R35 Gene

Protein phosphatase 1, regulatory subunit 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPP1R35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R35 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2:
SP3:

Relevant External Links for PPP1R35 Gene

GeneLoc Exon Structure for
PPP1R35
ECgene alternative splicing isoforms for
PPP1R35

Expression for PPP1R35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R35 Gene

This gene is overexpressed in Pancreatic juice (51.0) and Testis (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R35 Gene



Protein tissue co-expression partners for PPP1R35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R35 Gene:

PPP1R35

SOURCE GeneReport for Unigene cluster for PPP1R35 Gene:

Hs.413359
genes like me logo Genes that share expression patterns with PPP1R35: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R35 Gene

Orthologs for PPP1R35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R35 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia PPP1R35 33 34
  • 85.71 (n)
cow
(Bos Taurus)
Mammalia PPP1R35 33 34
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Ppp1r35 33 16 34
  • 77.64 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP1R35 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP1R35 34
  • 32 (a)
OneToOne
Species where no ortholog for PPP1R35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R35 Gene

ENSEMBL:
Gene Tree for PPP1R35 (if available)
TreeFam:
Gene Tree for PPP1R35 (if available)

Paralogs for PPP1R35 Gene

No data available for Paralogs for PPP1R35 Gene

Variants for PPP1R35 Gene

Sequence variations from dbSNP and Humsavar for PPP1R35 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001031038 -- 100,437,751(+) AGTCT(C/T)GCTCT intron-variant, upstream-variant-2KB
rs1001553730 -- 100,435,292(+) TAGCA(A/G)AATTA upstream-variant-2KB, utr-variant-3-prime
rs1001940656 -- 100,435,441(+) AGAGG(A/G)GGCAG upstream-variant-2KB, reference, synonymous-codon, utr-variant-3-prime
rs1002502362 -- 100,435,000(+) GGGCT(C/T)TGCAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003504474 -- 100,436,056(+) AGGCG(A/G)AAGCG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PPP1R35 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv527107 CNV loss 19592680
nsv831071 CNV loss 17160897

Variation tolerance for PPP1R35 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R35 Gene

Disorders for PPP1R35 Gene

Relevant External Links for PPP1R35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R35

No disorders were found for PPP1R35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R35 Gene

Publications for PPP1R35 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for PPP1R35 Gene

Sources for PPP1R35 Gene

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