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PPP1R3A Gene

protein-coding GIFtS: 62

GC07M113301

protein phosphatase 1, regulatory (inhibitor) subunit 3A
(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PPP1R3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
GM ^²
PP1G ^², ³
PPP1R3 ^², ⁵

Descriptions
Protein phosphatase 1 glycogen-associated regulatory subunit ^³
Protein phosphatase type-1 glycogen targeting subunit ^², ³
glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle ^²
protein phosphatase 1 glycogen- associated regulatory subunit ^²
protein phosphatase 1, regulatory (inhibitor) subunit 3A ^²
protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle) ^¹
serine /threonine specific protein phosphatase ^²
type-1 protein phosphatase skeletal muscle glycogen targeting subunit ^²

External Ids
HGNC: 9291¹
Entrez Gene: 5506²
UniProtKB: Q16821³
Ensembl: ENSG00000154415⁷

Search outside databases for aliases for PPP1R3A gene

Previous GC identifers: GC07M111992 GC07M113055 GC07M113068 GC07M113108

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PPP1R3A:

The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a

heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit.

This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity,

thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase

and glycogen phosphorylase kinase. [provided by RefSeq]

UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821

Function: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division,

and participates in the regulation of glycogen metabolism, muscle contractility and protein

synthesis. Plays an important role in glycogen synthesis but is not essential for insulin

activation of glycogen synthase (By similarity)

Gene Wiki entry for PPP1R3A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PPP1R3A gene

Entrez Gene cytogenetic band: 7q31.1 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31.1

PPP1R3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M113301: (about GC identifiers)

Start:	113,301,622 bp from pter
End:	113,346,300 bp from pter
Size:	44,679 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 112,909,741-112,954,428

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821 (See protein sequence)

Recommended Name: Protein phosphatase 1 regulatory subunit 3A

Size: 1122 amino acids; 125837 Da

Subunit: Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen (By

similarity)

Subcellular location: Membrane; Single-pass membrane protein (By similarity)

Sequence caution: Sequence=AAS07492.1; Type=Erroneous gene model prediction;

Secondary accessions: A0AVQ2 A4D0T6 O43476 Q75LN8 Q7KYM8 Q86UI6

Alternative splicing: 2 isoforms: Q16821-1 Q16821-2

Post-translational modifications:

Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and

phosphorylase kinase (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002702.2

ENSEMBL proteins:

ENSP00000284601 ENSP00000284602

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (PPP1R3A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for PPP1R3A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for PPP1R3A

Assays for PPP1R3A:

	Browse Invitrogen for biochemical assays
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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16821

ProtoNet protein and cluster: Q16821

1 Blocks protein family: IPB005036 Putative phosphatase regulatory subunit

UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821

Domain: The CBM21 domain is known to be involved in the localization to glycogen and is

characteristic of some regulatory subunit of phosphatase complexes

Similarity: Contains 1 CBM21 (carbohydrate binding type-21) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PPP1R3A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPP1R3A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002711

Applied Biosystems Silencer® siRNAs for PPP1R3A

Sigma-Aldrich siRNA and siRNA Panels for PPP1R3A

Sigma-Aldrich shRNA Panels and shRNA for PPP1R3A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002711
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002711
untagged cDNA clone in CMV expression vector: NM_002711

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002711

UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821

Function: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division,

and participates in the regulation of glycogen metabolism, muscle contractility and protein

synthesis. Plays an important role in glycogen synthesis but is not essential for insulin

activation of glycogen synthase (By similarity)

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppp1r3a):

adipose tissue

growth/size

homeostasis/metabolism

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for PPP1R3A (Your Favorite Gene powered by Ingenuity) (see all 6 )

CDK5 Signaling
Cardiac &beta
Insulin Receptor Signaling
Dopamine Receptor Signaling
ERK/MAPK Signaling

GeneDecks PPP1R3A for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PPP1R3A

5/28 Interacting proteins for PPP1R3A (ENSP00000284601³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INS	ENSP00000370731³	STRING (score=.98)
GYS2	ENSP00000261195³	STRING (score=.97)
PPP1CC	ENSP00000341779³	STRING (score=.966)
GYS1	ENSP00000317904³	STRING (score=.965)
INSR	ENSP00000303830³	STRING (score=.954)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	IEA	--
GO:0005977	glycogen metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PPP1R3A

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PPP1R3A
4 Novoseek chemical compound relationships for PPP1R3A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	74.23	53	11361130 (3), 1651242 (2), 12606498 (2), 10907117 (2) (see all 18)
glucose	46.33	5	14694850 (1), 9814479 (1), 10868947 (1), 10907117 (1)
glucose 6-phosphate	28.38	2	9148744 (1)
lipid	0.00	1	12118251 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PPP1R3A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPP1R3A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002711

Sigma-Aldrich siRNA and siRNA Panels for PPP1R3A

Sigma-Aldrich shRNA Panels and shRNA for PPP1R3A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002711

REFSEQ mRNAs for PPP1R3A gene:

NM_002711.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002711

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002711
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002711
                                 untagged cDNA clone in CMV expression vector: NM_002711

Additional cDNA sequence:

AF024579.1 BC017405.1 BC056666.1 BC070313.1 BC126451.1 BC126453.1 X78578.1

3 DOTS entries:

DT.109325 DT.91810752 DT.95320696

24/27 AceView cDNA sequences (see all 27 ):

AL598231 AI336142 BX500352 BC056666 AF024579 BF791239 AL600065 BX500591

BX283518 BF791215 BF693530 BC017405 NM_002711 BC070313 X78578 BF693311

F00032 BF576879 BF694832 BG194223 AW118744 AA176401 BF672236 BF791088

highest scoring ESTs for PPP1R3A:

AF024579 BC056666 BC070313 BF576879 BF791215 X78578 AA176401 AI336142 AL598231 AL600065

Unigene Cluster for PPP1R3A:

Protein phosphatase 1, regulatory (inhibitor) subunit 3A

Hs.458309 [show with all ESTs]

Unigene Representative Sequence: X78578

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3A

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for PPP1R3A

2 Ensembl transcripts including schematic representations:

ENST00000284601 ENST00000284602

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PPP1R3A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PPP1R3A

¹ / ² / ³

5 probe-sets matching PPP1R3A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35518_at²^{, 3}	U95-A	1	0.94	1.00	1.00	1.00	AF024578	0.20	1.00	0.72	1
211169_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF024579	0.80	1.00	0.91	1
206895_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_002711	0.60	1.00	0.82	1
211169_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206895_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks PPP1R3A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.458309
Expression variation in blood from EXPOLDB for PPP1R3A
UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821
Tissue specificity: Skeletal muscle and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PPP1R3A gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PPP1R3A¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	87.49(n) 77.15(a)	482411 XM_539528.2 XP_539528.2
chimpanzee (Pan troglodytes)	PPP1R3A¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	99.58(n) 99.29(a)	463666 XM_519320.2 XP_519320.2
cow (Bos taurus)	PPP1R3A¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	86.41(n) 75.43(a)	784877 XM_001252311.1 XP_001252312.1
rat (Rattus norvegicus)	Ppp1r3a¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	77.71(n) 65.96(a)	500036 XM_575392.2 XP_575392.1
mouse (Mus musculus)	Ppp1r3a^{1, 5}	6⁵	protein phosphatase 1, regulatory (inhibitor) subunit more^{1, 5}	77.15(n)¹ 63.75(a)¹	140491¹ NM_080464.2¹ NP_536712.2¹ AF309628⁵ AF309629⁵ (see all 11)

About this table Species with no ortholog for PPP1R3A

ENSEMBL Gene Tree for PPP1R3A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PPP1R3A gene

PPP1R3B² PPP1R3E² PPP1R3D² PPP1R3C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/175 NCBI SNPs in PPP1R3A are shown (see all 175 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10274994^1,2	A,C,F,H	113302589(+)	`TCTTAG/CCCAAC`	1	--	ut3¹ ese³		4	EU EA WA	416
	rs2974939^1,2	A,C,F,H	113303559(-)	`GAGTAA/CAACTT`	1	--	ut3¹		12	EA NA EU WA	1048
	rs7789198^1,2	A,C,F,H	113303463(+)	`ATCATT/CTACTA`	1	--	ut3¹		8	EU EA WA	832
	rs7795394^1,2	A,C,F,H	113347843(+)	`TTTTAA/TAAAGA`	1	--	ng3¹		4	EU EA WA	418
	rs10953744^1,2	A,C,F,H	113303639(+)	`ATGAAG/TGAATT`	1	--	ut3¹		4	EU EA WA	416
	rs2974942^1,2	C,F,H	113307032(-)	`GCACAA/GTGCAA`	1	V/M	mis¹ ese³		9	EU EA WA NA	880
	rs2968845^1,2	C,F,H	113303852(-)	`AATGCG/AAAGAT`	1	--	ut3¹		8	EU EA WA	836
	rs1799999^1,2	C,F,H	113305670(-)	`ACTCAG/TACACT`	1	D/Y	mis¹ ese³		18	EU EA NA WA	2419
	rs8192687^1,2	C,F,H	113346155(-)	`GACGAG/AGTTCT`	1	S/G	mis¹		5	EU EA WA	1339
	rs2974938^1,2	C,F,H	113305738(-)	`AGATCA/TTAGGC`	1	L/H	mis¹ ese³		12	EU EA WA	1258

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HapMap Linkage Disequilibrium images for PPP1R3A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600917 disorders: 604367

UniProtKB/Swiss-Prot: PPR3A_HUMAN, Q16821

Defects in PPP1R3A are a cause of susceptibility to noninsulin-dependent diabetes mellitus

(NIDDM) [MIM:125853]; also known as diabetes mellitus type II. NIDDM is characterized by an

autosomal dominant mode of inheritance, onset during adulthood and insulin resistance

Defects in PPP1R3A are a cause of insulin resistance (Ins resistance)

10/13 Novoseek disease relationships for PPP1R3A gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	61.55	12	9726244 (2), 10389856 (1), 14694850 (1), 12185156 (1) (see all 9)
niddm	46.91	8	9653600 (2), 15231141 (2), 7926294 (1), 11793847 (1) (see all 5)
insulin sensitivity	38.15	2	10868947 (2)
somatic mutations	31.17	5	10698503 (3)
impaired glucose tolerance	30.35	1	10868947 (1)
small cell lung cancer	24.97	1	10485448 (1)
nsclc	14.13	2	10485448 (1)
colorectal cancer	14.01	3	15870946 (2), 10485448 (1)
ovarian cancer	10.23	1	10485448 (1)
gastric cancer	9.01	1	10485448 (1)

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Human Gene Mutation Database: PPP1R3A
Genetic Association Database: PPP1R3A
Human Genome Epidemiology Navigator: PPP1R3A (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/56 PubMed articles for PPP1R3A gene (see all 56 ):

Sequence of the human glycogen-associated regulatory subunit of type I protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with non-insulin-dependent diabetes. (PubMed id 7926294)^{1, 2, 3, 4} Chen Y.H.... Pederson O. (1994)
A widespread amino acid polymorphism at codon 905 of the glycogen- associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. (PubMed id 7581368)^{3, 4, 6} Hansen L.... Pedersen O. (1995)
PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis. (PubMed id 15870946)^{1, 3, 6} Hayashida Y....Yamaguchi A. (2005)
[Study on association of PPP1R3 gene 5 bp deletion/insertion within 3'-untranslated region polymorphism with type 2 diabetes] (PubMed id 14767904)^{1, 3, 6} Chen M.W....Sun H.Y. (2004)
[Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province] (PubMed id 15231141)^{1, 3, 6} Chen M.W....Sun H.Y. (2004)
The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. (PubMed id 11793847)^{1, 3, 6} Wang G....Xu X. (2001)
A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. (PubMed id 9726244)^{1, 3, 4} Xia J.... Prochazka M. (1998)
Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. (PubMed id 15181086)^{1, 3, 6} Alcoser S.Y....Ehrmann D.A. (2004)
Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population. (PubMed id 16276364)^{1, 3, 6} Pollex R.L....Hegele R.A. (2006)
Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. (PubMed id 12185156)^{1, 3, 6} Liolitsa D....Lovestone S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5506	HGNC: 9291	AceView: PPP1R3A	Ensembl:ENSG00000154415	euGenes: HUgn5506
ECgene: PPP1R3A	H-InvDB: PPP1R3A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PPP1R3A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PPP1R3A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PPP1R3A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PPP1R3A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PPP1R3A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PPP1R3A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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PPP1R3A Gene at Home site.
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PPP1R3A Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for PPP1R3A

Summaries
for PPP1R3A

Genomic Location
for PPP1R3A

Proteins
for PPP1R3A

Protein Domains/
Families
for PPP1R3A

Gene Function
for PPP1R3A

Pathways & Interactions
for PPP1R3A

Drugs & Compounds
for PPP1R3A

Transcripts
for PPP1R3A

Expression
for PPP1R3A

Orthologs
for PPP1R3A

Paralogs
for PPP1R3A

SNPs/Variants
for PPP1R3A

Disorders & Mutations
for PPP1R3A

Medical News
for PPP1R3A

Publications
for PPP1R3A

Search for PPP1R3A

Genome Databases showing PPP1R3A

Other Databases showing PPP1R3A

Specialized Databases showing PPP1R3A

Licensable Technologies
for PPP1R3A

Services
for PPP1R3A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PPP1R3A Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor PPP1R3A

Summariesfor PPP1R3A

Genomic Locationfor PPP1R3A

Proteinsfor PPP1R3A

Protein Domains/Familiesfor PPP1R3A

Gene Functionfor PPP1R3A

Pathways & Interactionsfor PPP1R3A

Drugs & Compoundsfor PPP1R3A

Transcriptsfor PPP1R3A

Expression for PPP1R3A

Orthologsfor PPP1R3A

Paralogsfor PPP1R3A

SNPs/Variantsfor PPP1R3A

Disorders & Mutationsfor PPP1R3A

Medical Newsfor PPP1R3A

Publicationsfor PPP1R3A

Search for PPP1R3A

Genome Databases showing PPP1R3A

Other Databases showing PPP1R3A

Specialized Databases showing PPP1R3A

Licensable Technologiesfor PPP1R3A

Servicesfor PPP1R3A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PPP1R3A

Summaries
for PPP1R3A

Genomic Location
for PPP1R3A

Proteins
for PPP1R3A

Protein Domains/
Families
for PPP1R3A

Gene Function
for PPP1R3A

Pathways & Interactions
for PPP1R3A

Drugs & Compounds
for PPP1R3A

Transcripts
for PPP1R3A

Expression
for PPP1R3A

Orthologs
for PPP1R3A

Paralogs
for PPP1R3A

SNPs/Variants
for PPP1R3A

Disorders & Mutations
for PPP1R3A

Medical News
for PPP1R3A

Publications
for PPP1R3A

Licensable Technologies
for PPP1R3A

Services
for PPP1R3A