Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R21 Gene

Aliases for PPP1R21 Gene

  • Protein Phosphatase 1 Regulatory Subunit 21 2 3 5
  • Coiled-Coil Domain-Containing Protein 128 3 4
  • Coiled-Coil Domain Containing 128 2 3
  • KLRAQ Motif-Containing Protein 1 3 4
  • KLRAQ Motif Containing 1 2 3
  • CCDC128 3 4
  • KLRAQ1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 21 2

External Ids for PPP1R21 Gene

Previous HGNC Symbols for PPP1R21 Gene

  • CCDC128
  • KLRAQ1

Previous GeneCards Identifiers for PPP1R21 Gene

  • GC02P048670

Summaries for PPP1R21 Gene

GeneCards Summary for PPP1R21 Gene

PPP1R21 (Protein Phosphatase 1 Regulatory Subunit 21) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R21 Gene

Genomics for PPP1R21 Gene

Regulatory Elements for PPP1R21 Gene

Enhancers for PPP1R21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F048478 0.6 ENCODE 47.4 +39.6 39597 2.6 CTCF FOXA3 ZNF644 FOXA1 ZFHX2 FOXK2 SMARCA4 SCRT2 GABPB1 ZBTB33 PPP1R21 FOXN2 RNU6-282P STON1 STON1-GTF2A1L GC02M048450 GC02M048502
GH02F048474 0.6 ENCODE 35.7 +34.1 34141 1.3 ZNF146 NR2F2 PPP1R21 RNU6-282P STON1 STON1-GTF2A1L GC02M048450 GC02M048502
GH02F048443 0.5 Ensembl 34.9 +4.2 4203 3.2 ZNF263 GATA3 TBL1XR1 HLF FOS REST MAFK PPP1R21 FOXN2 RNU6-282P STON1-GTF2A1L GC02M048441 GC02M048449 PIR50991
GH02F048519 0.7 ENCODE 34.8 +79.0 78988 0.8 PPP1R21 STON1 GTF2A1L GC02M048502 RNU6-282P
GH02F048507 1 FANTOM5 Ensembl ENCODE 33.5 +68.9 68855 3.3 PKNOX1 ATF1 ARID4B ETS1 ELK1 GATA2 SMARCB1 MEF2D SMARCA4 PBX2 PPP1R21 STON1-GTF2A1L STON1 GC02M048502 RNU6-282P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPP1R21 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001542212 302 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5

Genomic Location for PPP1R21 Gene

48,440,598 bp from pter
48,515,392 bp from pter
74,795 bases
Plus strand

Genomic View for PPP1R21 Gene

Genes around PPP1R21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R21 Gene

Proteins for PPP1R21 Gene

  • Protein details for PPP1R21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 21
    Protein Accession:
    Secondary Accessions:
    • B7ZKY5
    • B7ZKY7
    • E1B6W7
    • Q2TA78
    • Q6ZMI6
    • Q8IW83
    • Q8J029
    • Q96ES8

    Protein attributes for PPP1R21 Gene

    780 amino acids
    Molecular mass:
    88314 Da
    Quaternary structure:
    • Interacts with PPP1CA.
    • Sequence=AAH11978.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18739.1; Type=Frameshift; Positions=115; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R21 Gene


neXtProt entry for PPP1R21 Gene

Post-translational modifications for PPP1R21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R21 Gene

Domains & Families for PPP1R21 Gene

Gene Families for PPP1R21 Gene

Protein Domains for PPP1R21 Gene

Suggested Antigen Peptide Sequences for PPP1R21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R21: view

No data available for UniProtKB/Swiss-Prot for PPP1R21 Gene

Function for PPP1R21 Gene

Gene Ontology (GO) - Molecular Function for PPP1R21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with PPP1R21: view

Phenotypes for PPP1R21 Gene

genes like me logo Genes that share phenotypes with PPP1R21: view

Animal Model Products

miRNA for PPP1R21 Gene

miRTarBase miRNAs that target PPP1R21

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R21 Gene

Localization for PPP1R21 Gene

Subcellular locations from

Jensen Localization Image for PPP1R21 Gene COMPARTMENTS Subcellular localization image for PPP1R21 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PPP1R21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PPP1R21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R21 Gene

Pathways & Interactions for PPP1R21 Gene

SuperPathways for PPP1R21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R21 Gene


No data available for Pathways by source and SIGNOR curated interactions for PPP1R21 Gene

Transcripts for PPP1R21 Gene

Unigene Clusters for PPP1R21 Gene

Protein phosphatase 1, regulatory subunit 21:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2: - - - -
SP3: - -
SP5: -
SP7: -

ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2: -
SP7: -

Relevant External Links for PPP1R21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R21 Gene

Protein differential expression in normal tissues from HIPED for PPP1R21 Gene

This gene is overexpressed in Lymph node (12.7) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R21 Gene

Protein tissue co-expression partners for PPP1R21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R21 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R21 Gene:

genes like me logo Genes that share expression patterns with PPP1R21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R21 Gene

Orthologs for PPP1R21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRAQ1 34 35
  • 99.74 (n)
(Bos Taurus)
Mammalia KLRAQ1 35
  • 95 (a)
PPP1R21 34
  • 91.58 (n)
(Canis familiaris)
Mammalia PPP1R21 34 35
  • 92.56 (n)
(Monodelphis domestica)
Mammalia PPP1R21 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Ppp1r21 34
  • 87.56 (n)
(Mus musculus)
Mammalia Ppp1r21 34 16 35
  • 86.97 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R21 35
  • 60 (a)
(Gallus gallus)
Aves PPP1R21 34 35
  • 78.41 (n)
(Anolis carolinensis)
Reptilia PPP1R21 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r21 34
  • 71.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14159 34
(Danio rerio)
Actinopterygii ppp1r21 34 35
  • 60.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6607 35
  • 32 (a)
(Caenorhabditis elegans)
Secernentea F33E11.3 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7865 34
Species where no ortholog for PPP1R21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R21 Gene

Gene Tree for PPP1R21 (if available)
Gene Tree for PPP1R21 (if available)

Paralogs for PPP1R21 Gene

No data available for Paralogs for PPP1R21 Gene

Variants for PPP1R21 Gene

Sequence variations from dbSNP and Humsavar for PPP1R21 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164898 -- 48,487,657(+) TTGGG(A/T)GGCTG intron-variant
rs10183526 -- 48,477,267(+) gtgtg(C/T)gccac intron-variant
rs10185212 -- 48,493,848(+) AGTCC(G/T)TATGG intron-variant
rs10190508 -- 48,509,541(+) ctcta(C/G)taaaa intron-variant
rs10195279 -- 48,456,037(+) AAAAA(A/G/T)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R21 Gene

Variant ID Type Subtype PubMed ID
dgv1120e212 CNV loss 25503493
esv1932167 CNV deletion 18987734
esv2548827 CNV deletion 19546169
esv2656842 CNV deletion 23128226
esv2762252 CNV gain 21179565
esv3583787 CNV loss 25503493
nsv581775 CNV loss 21841781
nsv833981 CNV loss 17160897

Variation tolerance for PPP1R21 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R21 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R21 Gene

Disorders for PPP1R21 Gene

Relevant External Links for PPP1R21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R21 Gene

Publications for PPP1R21 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PPP1R21 Gene

Sources for PPP1R21 Gene

Loading form....