PPP1R21 Gene
protein-coding GIFtS: 44
GCID: GC02P048670
|
|
protein phosphatase 1, regulatory subunit 21(Previous names: coiled-coil domain containing 128, KLRAQ motif containing...)
(Previous symbols: CCDC128, KLRAQ1)
| |
Aliases
for PPP1R21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Protein Phosphatase 1, Regulatory Subunit 211 2 | | Coiled-Coil Domain-Containing Protein 1282 3 | | CCDC1281 2 3 | | KLRAQ Motif-Containing Protein 12 3 | | KLRAQ11 2 3 | | FLJ165661 | | Coiled-Coil Domain Containing 1281 2 | | Protein Phosphatase 1 Regulatory Subunit 212 | | KLRAQ Motif Containing 11 2 | | |
| External Ids: | HGNC: 305951 | Entrez Gene: 1292852 | Ensembl: ENSG000001628697 | UniProtKB: Q6ZMI03 | | ORGUL members: | |
|---|
| NONCODE:n406657 | |
Export aliases for PPP1R21 gene to outside databases
|---|
Summaries
for PPP1R21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PPP1R21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PPP1R21
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP1R21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p16.3 Ensembl cytogenetic band: 2p16.3 HGNC cytogenetic band: 2p16.3PPP1R21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P048670: view genomic region
(about GC identifiers)
Start:
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48,667,737 bp from pter |
End:
|
48,742,531 bp from pter |
Size:
|
74,795 bases |
Orientation:
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plus strand |
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Proteins
for PPP1R21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPR21_HUMAN, Q6ZMI0 (See
protein sequence)Recommended Name: Protein phosphatase 1 regulatory subunit 21 Size: 780 amino acids; 88314 Da
Subunit: Interacts with PPP1CA
Sequence caution: Sequence=AAH11978.2; Type=Erroneous initiation; Sequence=BAD18739.1; Type=Frameshift; Positions=115;
Secondary accessions: B7ZKY5 B7ZKY7 E1B6W7 Q2TA78 Q6ZMI6 Q8IW83 Q8J029 Q96ES8Alternative splicing: 5 isoforms: Q6ZMI0-1 Q6ZMI0-2 Q6ZMI0-5 Q6ZMI0-3 Q6ZMI0-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PPP1R21: NX_Q6ZMI0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZMI0
PPP1R21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129101.1 NP_001180404.1 NP_694539.1
ENSEMBL proteins: ENSP00000406283 ENSP00000414130 ENSP00000281394 ENSP00000294952 ENSP00000410955 ENSP00000403001 ENSP00000415696
Human Recombinant Protein Products:
PPP1R21 Antibody Products:
Assay Products for PPP1R21: |
Protein
Domains /
Families
for PPP1R21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP1R21 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZMI0ProtoNet protein and cluster: Q6ZMI0 |
Function
for PPP1R21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R21 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
PPP1R21 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PPP1R21:
|
Pathways & Interactions
for PPP1R21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP1R21
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/8 Interacting proteins for PPP1R21 (Q6ZMI02, 3 ENSP000002949524) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for PPP1R21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PPP1R21
Search CenterWatch for drugs/clinical trials and news about PPP1R21 / PPR21
|
Transcripts
for PPP1R21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPP1R21 gene (4 alternative transcripts): NM_001135630.1 NM_001135629.2 NM_001193475.1 NM_152994.4 Unigene Cluster for PPP1R21: Protein phosphatase 1, regulatory subunit 21 Hs.654619 [show with all ESTs]Unigene Representative Sequence: NR_0241889 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431614 ENST00000416913(uc002rwl.3 uc002rwm.3) ENST00000281394(uc002rwi.1 uc002rwj.3 uc002rwk.3 uc010yok.2)
ENST00000294952 ENST00000421486 ENST00000460299 ENST00000455978 ENST00000476199
ENST00000449090
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R21 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for PPP1R21 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP1R21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R21 |
Additional cDNA sequence: AK122900.1 AK172753.1 AK172762.1 AK307755.1 AY092062.1 AY134855.1 BC011978.2 BC040721.1 BC111059.1 BC117279.1 BC143463.1 BC143466.1 NR_024188.2 13 DOTS entries: DT.102832084 DT.97837289 DT.100754585 DT.100754583 DT.432390 DT.120994711 DT.95344164 DT.40309449 DT.87007460 DT.91745178 DT.99934783 DT.100674624 DT.75179495 24/78 AceView cDNA sequences (see all 78): BC040721 AI493782 CD366311 BM466190 BP376808 CD672757 BQ185658 AA308904 BQ223252 AI270140 BG675957 AI139950 CB125578 BE254064 BM723501 BQ636976 CA416843 CN481571 AI862792 BC011978 BQ893382 BI772002 BI521458 CB994666
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R21 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 |
|---|
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| SP1: | - | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PPP1R21
|
Expression
for PPP1R21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPP1R21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAATAAATT
About this image
See PPP1R21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP1R21
SOURCE GeneReport for Unigene cluster: Hs.654619
SABiosciences Custom PCR Arrays for PPP1R21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R21
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PPP1R21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R21 |
Orthologs
for PPP1R21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PPP1R21 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for PPP1R21 (if available)
TreeFam Gene Tree for PPP1R21 (if available) |
Paralogs
for PPP1R21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PPP1R21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPP1R21 (48667737 - 48742531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP1R21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1R21 |
|
Disorders
/ Diseases
for PPP1R21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PPP1R21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPP1R21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PPP1R21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1, 2 Hendrickx A.... Bollen M. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for PPP1R21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPP1R21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPP1R21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPP1R21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PPP1R21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PPP1R21 gene:
Search GeneIP for patents involving PPP1R21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPP1R21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for PPP1R21 |
| |  |  |  |  | | | | |
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 | | | PPP1R21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R21 |
|  |  |  | | | | Search ThermoFisher Antibodies for PPP1R21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R21 |
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