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PPP1R21 Gene

protein-coding   GIFtS: 41
GCID: GC02P048670

Protein Phosphatase 1, Regulatory Subunit 21

(Previous names: coiled-coil domain containing 128, KLRAQ motif containing...)
(Previous symbols: CCDC128, KLRAQ1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 211 2     KLRAQ Motif Containing 11 2
CCDC1281 2 3     Coiled-Coil Domain-Containing Protein 1282 3
KLRAQ11 2 3     KLRAQ Motif-Containing Protein 12 3
Coiled-Coil Domain Containing 1281 2     Protein Phosphatase 1 Regulatory Subunit 212

External Ids:    HGNC: 305951   Entrez Gene: 1292852   Ensembl: ENSG000001628697   UniProtKB: Q6ZMI03   

Export aliases for PPP1R21 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPP1R21 Gene:
PPP1R21 (protein phosphatase 1, regulatory subunit 21) is a protein-coding gene. Diseases associated with PPP1R21 include malaria. GO annotations related to this gene include phosphatase binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PPP1R21
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R21 promoter sequence
   Search Chromatin IP Primers for PPP1R21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p16.3

PPP1R21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R21 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P048670:  view genomic region     (about GC identifiers)

Start:
48,667,737 bp from pter      End:
48,742,531 bp from pter
Size:
74,795 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPR21_HUMAN, Q6ZMI0 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 21  
Size: 780 amino acids; 88314 Da
Subunit: Interacts with PPP1CA
Sequence caution: Sequence=AAH11978.2; Type=Erroneous initiation; Sequence=BAD18739.1; Type=Frameshift;
Positions=115;
Secondary accessions: B7ZKY5 B7ZKY7 E1B6W7 Q2TA78 Q6ZMI6 Q8IW83 Q8J029 Q96ES8
Alternative splicing: 5 isoforms:  Q6ZMI0-1   Q6ZMI0-2   Q6ZMI0-5   Q6ZMI0-3   Q6ZMI0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP1R21: NX_Q6ZMI0

Explore proteomics data for PPP1R21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129101.1  NP_001180404.1  NP_694539.1  

    ENSEMBL proteins: 
     ENSP00000406283   ENSP00000414130   ENSP00000281394   ENSP00000294952   ENSP00000410955  
     ENSP00000403001   ENSP00000415696  

    PPP1R21 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    2 InterPro protein domains:
     IPR019343 Unchr_KLRAQ/TTKRSYEDQ_N
     IPR019348 KLRAQ/TTKRSYEDQ_C

    Graphical View of Domain Structure for InterPro Entry Q6ZMI0

    ProtoNet protein and cluster: Q6ZMI0


    PPP1R21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019902phosphatase binding IDA19389623
         
    PPP1R21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP1R21:
     Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1R21
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1R21

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPPP1R21 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1R21

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R21

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP1R21
    Interactions:

        Search GeneGlobe Interaction Network for PPP1R21

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for PPP1R21 (Q6ZMI02, 3 ENSP000002949524) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL2Q999622, 3, ENSP000003699814MINT-8270506 I2D: score=2 STRING: ENSP00000369981
    C21orf59P570763, ENSP000002901554I2D: score=5 STRING: ENSP00000290155
    NUP88Q995673I2D: score=5 
    TCEB3Q142413I2D: score=5 
    TMEM55BQ86T033I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R21 (PPR21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP1R21 gene (4 alternative transcripts): 
    NM_001135630.1  NM_001135629.2  NM_001193475.1  NM_152994.4  

    Unigene Cluster for PPP1R21:

    Protein phosphatase 1, regulatory subunit 21
    Hs.654619  [show with all ESTs]
    Unigene Representative Sequence: NR_024188
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431614 ENST00000416913(uc002rwl.3 uc002rwm.3) ENST00000281394(uc002rwi.1 uc002rwj.3 uc002rwk.3 uc010yok.2)
    ENST00000294952 ENST00000421486 ENST00000460299 ENST00000455978 ENST00000476199
    ENST00000449090
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPPP1R21 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1R21
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R21
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP1R21
      QuantiFast Probe-based Assays in human, mouse, rat PPP1R21

    Additional mRNA sequence: 

    AK122900.1 AK172753.1 AK172762.1 AK307755.1 AY092062.1 AY134855.1 BC011978.2 BC040721.1 
    BC111059.1 BC117279.1 BC143463.1 BC143466.1 NR_024188.2 

    13 DOTS entries:

    DT.102832084  DT.97837289  DT.100754585  DT.100754583  DT.432390  DT.120994711  DT.95344164  DT.40309449 
    DT.87007460  DT.91745178  DT.99934783  DT.100674624  DT.75179495 

    Selected AceView cDNA sequences (see all 78):

    CD366311 BE254064 BQ223252 BQ185658 CA416843 BM466190 CD672757 BP376808 
    BQ636976 CN481571 AI493782 AI139950 AA308904 BG675957 BC040721 CB125578 
    BM723501 AI270140 BG697894 BG529855 CA423765 NM_152994 BC011978 AW295126 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R21 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:              -                                                                             -           -                                                   
    SP2:              -           -                                                                 -           -                                                   
    SP3:              -           -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24
    SP1:  -                                 
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for PPP1R21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATAAATT
    PPP1R21 Expression
    About this image

    PPP1R21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654619
        Custom PCR Arrays for PPP1R21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R21 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r211 , 5 KLRAQ motif containing 15
    protein phosphatase 1, regulatory subunit 211
    86.97(n)1
    92.05(a)1
      17 (58.02 cM)5
    738251  NM_028658.41  NP_082934.31 
     885301245 
    chicken
    (Gallus gallus)
    Aves PPP1R211 protein phosphatase 1, regulatory subunit 21 78.41(n)
    82.58(a)
      421287  NM_001012873.1  NP_001012891.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R216
    protein phosphatase 1, regulatory subunit 21
    80(a)
    1 ↔ 1
    1(255459476-255510261)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141592 Xenopus laevis transcribed sequences 79.68(n)    AW644151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570593492   -- 75.75(n)    57059349 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66076
    --
    32(a)
    1 ↔ 1
    3R(20353798-20355537)
    worm
    (Caenorhabditis elegans)
    Secernentea F33E11.36
    Protein F33E11.3 (F33E11.3) mRNA, complete cds
    25(a)
    1 ↔ 1
    V(300036-304713) WBGene00018011


    ENSEMBL Gene Tree for PPP1R21 (if available)
    TreeFam Gene Tree for PPP1R21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R21 (see all 1938)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021782691,2
    C--48550813(+) AAAAA-/ATAGTAG 4 -- int10--------
    rs1478420791,2
    --48666013(+) TTCCTC/TGGAAT 4 -- us2k10--------
    rs1414644111,2
    --48666185(+) ACAGGC/TACCCG 4 -- us2k10--------
    rs1470249551,2
    --48666197(+) CACCAC/TGCCAG 4 -- us2k10--------
    rs1841341491,2
    --48666270(+) CTCTCG/TACCTC 4 -- us2k10--------
    rs43567051,2
    C,F,A--48666338(+) cgcccA/GgccGG 4 -- us2k18Minor allele frequency- G:0.35NA WA CSA 132
    rs1423755021,2
    --48666727(+) ACTTAC/TTGTAA 4 -- us2k10--------
    rs44340421,2
    C,F,A,H--48666736(+) AAAAAA/GTTAAA 4 -- us2k1 tfbs324Minor allele frequency- N:0.00NS EA NA WA 2546
    rs1887048101,2
    --48666744(+) AAAGAA/TATAAG 4 -- us2k10--------
    rs1502129671,2
    --48666815(+) AGGCAA/GCTACT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP1R21 (48667737 - 48742531 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PPP1R21: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1R21
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for PPP1R21:    
    About MalaCards
    malaria


    PPP1R21 for disorders           About GeneDecksing


    Export disorders for PPP1R21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R21 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PPP1R21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1, 2 Hendrickx A.... Bollen M. (Chem. Biol. 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129285 HGNC: 30595 AceView: LOC129285 Ensembl:ENSG00000162869 euGenes: HUgn129285
    ECgene: PPP1R21 H-InvDB: PPP1R21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP1R21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R21 gene:
    Search GeneIP for patents involving PPP1R21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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