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Aliases for PPP1R21 Gene

Aliases for PPP1R21 Gene

  • Protein Phosphatase 1, Regulatory Subunit 21 2 3
  • Coiled-Coil Domain-Containing Protein 128 3 4
  • Coiled-Coil Domain Containing 128 2 3
  • KLRAQ Motif-Containing Protein 1 3 4
  • KLRAQ Motif Containing 1 2 3
  • CCDC128 3 4
  • KLRAQ1 3 4

External Ids for PPP1R21 Gene

Previous HGNC Symbols for PPP1R21 Gene

  • CCDC128
  • KLRAQ1

Previous GeneCards Identifiers for PPP1R21 Gene

  • GC02P048670

Summaries for PPP1R21 Gene

GeneCards Summary for PPP1R21 Gene

PPP1R21 (Protein Phosphatase 1, Regulatory Subunit 21) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R21 Gene

Genomics for PPP1R21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1R21 Gene

48,440,598 bp from pter
48,515,392 bp from pter
74,795 bases
Plus strand

Genomic View for PPP1R21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R21 Gene

No data available for Regulatory Elements for PPP1R21 Gene

Proteins for PPP1R21 Gene

  • Protein details for PPP1R21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 21
    Protein Accession:
    Secondary Accessions:
    • B7ZKY5
    • B7ZKY7
    • E1B6W7
    • Q2TA78
    • Q6ZMI6
    • Q8IW83
    • Q8J029
    • Q96ES8

    Protein attributes for PPP1R21 Gene

    780 amino acids
    Molecular mass:
    88314 Da
    Quaternary structure:
    • Interacts with PPP1CA.
    • Sequence=AAH11978.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18739.1; Type=Frameshift; Positions=115; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R21 Gene


neXtProt entry for PPP1R21 Gene

Proteomics data for PPP1R21 Gene at MOPED

Post-translational modifications for PPP1R21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R21 Gene

Domains & Families for PPP1R21 Gene

Gene Families for PPP1R21 Gene

Protein Domains for PPP1R21 Gene

Suggested Antigen Peptide Sequences for PPP1R21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R21: view

No data available for UniProtKB/Swiss-Prot for PPP1R21 Gene

Function for PPP1R21 Gene

Gene Ontology (GO) - Molecular Function for PPP1R21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with PPP1R21: view

Phenotypes for PPP1R21 Gene

GenomeRNAi human phenotypes for PPP1R21:
genes like me logo Genes that share phenotypes with PPP1R21: view

Animal Model Products

CRISPR Products

miRNA for PPP1R21 Gene

miRTarBase miRNAs that target PPP1R21

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R21

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R21 Gene

Localization for PPP1R21 Gene

Subcellular locations from

Jensen Localization Image for PPP1R21 Gene COMPARTMENTS Subcellular localization image for PPP1R21 gene
Compartment Confidence
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PPP1R21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PPP1R21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R21 Gene

Pathways & Interactions for PPP1R21 Gene

SuperPathways for PPP1R21 Gene

No Data Available

Interacting Proteins for PPP1R21 Gene

Gene Ontology (GO) - Biological Process for PPP1R21 Gene


No data available for Pathways by source and SIGNOR curated interactions for PPP1R21 Gene

Drugs & Compounds for PPP1R21 Gene

No Compound Related Data Available

Transcripts for PPP1R21 Gene

Unigene Clusters for PPP1R21 Gene

Protein phosphatase 1, regulatory subunit 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2: - - - -
SP3: - -
SP5: -
SP7: -

ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2: -
SP7: -

Relevant External Links for PPP1R21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R21 Gene

mRNA expression in normal human tissues for PPP1R21 Gene

Protein differential expression in normal tissues from HIPED for PPP1R21 Gene

This gene is overexpressed in Lymph node (12.7) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R21 Gene

SOURCE GeneReport for Unigene cluster for PPP1R21 Gene Hs.654619

genes like me logo Genes that share expression patterns with PPP1R21: view

Protein tissue co-expression partners for PPP1R21 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R21 Gene

Orthologs for PPP1R21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R21 35
  • 91.58 (n)
  • 94.87 (a)
  • 95 (a)
(Canis familiaris)
Mammalia PPP1R21 35
  • 92.56 (n)
  • 95.64 (a)
PPP1R21 36
  • 92 (a)
(Mus musculus)
Mammalia Ppp1r21 35
  • 86.97 (n)
  • 92.05 (a)
Ppp1r21 16
Ppp1r21 36
  • 92 (a)
(Pan troglodytes)
Mammalia KLRAQ1 35
  • 99.74 (n)
  • 99.87 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppp1r21 35
  • 87.56 (n)
  • 93.21 (a)
(Monodelphis domestica)
Mammalia PPP1R21 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R21 36
  • 60 (a)
(Gallus gallus)
Aves PPP1R21 35
  • 78.41 (n)
  • 82.58 (a)
PPP1R21 36
  • 82 (a)
(Anolis carolinensis)
Reptilia PPP1R21 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r21 35
  • 71.56 (n)
  • 75.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14159 35
(Danio rerio)
Actinopterygii ppp1r21 35
  • 60.59 (n)
  • 61.19 (a)
ppp1r21 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6607 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea F33E11.3 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7865 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for PPP1R21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R21 Gene

Gene Tree for PPP1R21 (if available)
Gene Tree for PPP1R21 (if available)

Paralogs for PPP1R21 Gene

No data available for Paralogs for PPP1R21 Gene

Variants for PPP1R21 Gene

Sequence variations from dbSNP and Humsavar for PPP1R21 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2937 -- 48,477,752(+) TGATG(C/T)CTACA intron-variant
rs1143151 -- 48,490,056(+) aaaaa(A/C)aaaaa intron-variant
rs3811519 -- 48,498,471(+) AGATA(C/T)AACAC intron-variant
rs3811520 -- 48,440,625(-) TTGAC(C/T)CATGG upstream-variant-2KB
rs3811521 -- 48,440,606(-) GGCGA(C/T)CTGGA upstream-variant-2KB

Variation tolerance for PPP1R21 Gene

Residual Variation Intolerance Score: 12.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPP1R21 Gene

Disorders for PPP1R21 Gene

Relevant External Links for PPP1R21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPP1R21: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R21 Gene

Publications for PPP1R21 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 67
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for PPP1R21 Gene

Sources for PPP1R21 Gene

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