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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R2 Gene

protein-coding   GIFtS: 57
GCID: GC03M195241

protein phosphatase 1, regulatory (inhibitor) subunit 2
 Explore 8 diseases affiliated with
PPP1R2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPP1R2    

Aliases
for PPP1R2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 21 2
IPP21 2 3 5
IPP-22 3
Phosphatase Inhibitor 22
Phosphoprotein Phosphatase2
Protein Phosphatase Inhibitor 22

External Ids:    HGNC: 92881   Entrez Gene: 55042   Ensembl: ENSG000001842037   OMIM: 6017925   UniProtKB: P412363   

Export aliases for PPP1R2 gene to outside databases

Previous GC identifers: GC03M194496 GC03M198627 GC03M196641 GC03M196560 GC03M196722


Summaries
for PPP1R2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
Function: Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R2


Genomic Views
for PPP1R2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   HTF   Max   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPP1R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195241:  view genomic region     (about GC identifiers)

Start:
 195,241,221 bp from pter      End:
 195,270,224 bp from pter
Size:
 29,004 bases      Orientation:
 minus strand

Proteins
for PPP1R2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236 (See protein sequence)
Recommended Name: Protein phosphatase inhibitor 2  
Size: 205 amino acids; 23015 Da
Subunit: Heterodimer with PP1

Explore the universe of human proteins at neXtProt for PPP1R2: NX_P41236

Post-translational modifications:

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation
    • on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41236

    • PPP1R2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006232.1  
    ENSEMBL proteins: 
     ENSP00000328178   ENSP00000415175   ENSP00000400238   ENSP00000406725  

    Human Recombinant Protein Products: 
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    Novus Biologicals PPP1R2 Proteins
    Novus Biologicals PPP1R2 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PPP1R2


    PPP1R2 Antibody Products: 
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    Assay Products for PPP1R2: 
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    Uscn ELISAs and CLIAs for PPP1R2

    Protein Domains /
    Families
    for PPP1R2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPP1R2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007062 PPI-2

    Graphical View of Domain Structure for InterPro Entry P41236

    ProtoNet protein and cluster: P41236

    1 Blocks protein family: IPB007062 Protein phosphatase inhibitor 2 (IPP-2)

    UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
    Similarity: Belongs to the protein phosphatase inhibitor 2 family


    Function
    for PPP1R2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
    Function: Inhibitor of protein-phosphatase 1

         Genatlas biochemistry entry for PPP1R2:
    protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R2 (see all 51):
    hsa-miR-2052 hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-30d hsa-miR-374a hsa-miR-4275 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: PPP1R2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R2 (see all 7)
    OriGene shRNA RFP: PPP1R2
    OriGene siRNA: PPP1R2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPP1R2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R2 (see all 4)
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    GenScript: all cDNA clones in your preferred vector: PPP1R2 (NM_006241)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R2 

    Cell Line
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    Search LifeMap BioReagents cell lines for PPP1R2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity ----
    GO:0004865protein serine/threonine phosphatase inhibitor activity TAS8119416
    GO:0005515protein binding IPI12393858


    PPP1R2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PPP1R2:
     Decreased focal adhesion (FA)   Synthetic lethal with imatinib 


    Pathways & Interactions
    for PPP1R2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Erythropoietin Pathway
    		Erythropoietin Pathway1.00
    		Insulin Receptor Pathway0.37
    		Beta-Adrenergic Signaling0.37
    		CDK5 Pathway0.21
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    4PEDF Induced Signaling
    		IL-6 Pathway0.61
    5Rho Family GTPases
    		ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R2 (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R2
        Insulin Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP1R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for PPP1R2 (P412361, 2, 3 ENSP000003281784) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CCP368732, 3, ENSP000003350844MINT-8286998 MINT-8287012 MINT-8287084 I2D: score=3 STRING: ENSP00000335084
    GSK3BP498412, 3, ENSP000003248064MINT-8286998 MINT-8287012 I2D: score=2 STRING: ENSP00000324806
    LMTK2Q8IWU21, 3, ENSP000002972934EBI-1056517,EBI-2008933 I2D: score=4 STRING: ENSP00000297293
    PPP1CAP621362, 3, ENSP000003260314MINT-8287028 I2D: score=2 STRING: ENSP00000326031
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--
    GO:0006091generation of precursor metabolites and energy TAS9126490
    GO:0009966regulation of signal transduction IEA--
    GO:0043666regulation of phosphoprotein phosphatase activity IEA--


    PPP1R2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPP1R2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R2
    Search CenterWatch for drugs/clinical trials and news about PPP1R2 / IPP2 

    Transcripts
    for PPP1R2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPP1R2 gene: 
    NM_006241.4  

    Unigene Clusters for PPP1R2:

    Protein phosphatase 1, regulatory (inhibitor) subunit 2
    Hs.535731  [show with all ESTs], Hs.706920  [show with all ESTs]
    Unigene Representative Sequences: NM_006241, CF552101
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328432(uc003fup.3) ENST00000418939 ENST00000460437 ENST00000438848
    ENST00000413183 ENST00000462906(uc003fuq.4)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R2 (see all 51):
    hsa-miR-2052 hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-30d hsa-miR-374a hsa-miR-4275 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: PPP1R2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R2 (see all 7)
    OriGene shRNA RFP: PPP1R2
    OriGene siRNA: PPP1R2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R2

    Additional cDNA sequence: Y13810.1 

    13 DOTS entries:

    DT.449863  DT.95205535  DT.92439339  DT.99938577  DT.99945124  DT.95205533  DT.100794138  DT.100794145 
    DT.92439342  DT.100046027  DT.100794141  DT.100794146  DT.95205531 

    24/228 AceView cDNA sequences (see all 228):

    CR622597 BE274900 AI128684 AW591077 BM980382 BX486126 AI342289 BX111624 
    AI141349 CR619030 AI290075 AI383648 AA188658 AI650344 AA452763 X78873 
    AI361987 CB242116 AA987517 AA169809 AA826949 AI695140 BQ632564 AI375819 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                          -                           
    SP3:                                -                     


    ECgene alternative splicing isoforms for PPP1R2

    Expression
    for PPP1R2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTTTGGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PPP1R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R2

    SOURCE GeneReport for Unigene clusters: Hs.535731 Hs.706920
        SABiosciences Custom PCR Arrays for PPP1R2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R2

    Orthologs
    for PPP1R2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppp1r21 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 85.69(n)1
    84.39(a)1    		   16 (21.41 cM)5
    668491  NM_025800.31  NP_080076.11 
     312515375 
    chicken
    (Gallus gallus)    		 Aves PPP1R21 protein phosphatase 1, regulatory (inhibitor) subunit more 68.4(n)
    63.54(a)    		   424894  NM_001031313.1  NP_001026484.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPP1R26
    		 --
    		 57(a)
    		 1 ↔ 1
    		 AAWZ02038515(2651-6078)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.195082 Transcribed sequence with weak similarity to protein more 72.63(n)    CK360410.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta I-26
    CG63806
    (see all 3)    		 --
    		 21(a)
    19(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 3L(9827467-9829905)
    2L(17291134-17292202)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y32H12A.41 Protein Y32H12A.4 49.33(n)
    41.04(a)    		   175738  NM_065746.2  NP_498147.1 


    ENSEMBL Gene Tree for PPP1R2 (if available)
    TreeFam Gene Tree for PPP1R2 (if available) 

    Paralogs
    for PPP1R2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R2 gene
    3 SIMAP similar genes for PPP1R2 using alignment to 5 protein entries:     IPP2_HUMAN (see all proteins):
    PPP1R2P1    PPP1R2P3    PPP1R2P9

    PPP1R2 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for PPP1R2 (see all 11)
    PGOHUM00000248417 PGOHUM00000237216 PGOHUM00000239168 PGOHUM00000240239 PGOHUM00000243152


    Genomic Variants
    for PPP1R2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/544 NCBI SNPs in PPP1R2 are shown (see all 544)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs756909351,2
    		C,F,--195240743(+) ACTGCA/TAACAA 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1838380481,2
    		--195240819(+) TACTCC/TTAAAG 1 -- int10--------
    rs738908381,2
    		C,--195240869(+) AGGTAC/TAATTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1474170791,2
    		--195240902(+) AAATGC/TATGAA 1 -- int10--------
    rs1484448971,2
    		--195241087(+) CACAAC/TGCTAC 1 -- int10--------
    rs1427078841,2
    		--195241115(+) CTCGGC/TCACAG 1 -- int10--------
    rs1505818791,2
    		--195241170(+) GGATTA/TTGGTC 1 -- int10--------
    rs1396116231,2
    		--195241187(+) TAGCTA/GAGTAA 1 -- int10--------
    rs1883335671,2
    		--195241234(+) TTATTA/GTATTT 1 -- ut310--------
    rs1932604201,2
    		--195241273(+) TGAAAA/GGGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP1R2 (195241221 - 195270224 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PPP1R2
         4 CNVs: 80078 80079 91814 2491

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1R2
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R2

    Disorders / Diseases
    for PPP1R2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPP1R2 for disorders           About GeneDecksing

    OMIM gene information: 601792    OMIM disorders: --

    8 diseases for PPP1R2:    About MalaCards
    congenital stationary night blindness    night blindness    insulin resistance    blindness
    cardiomyopathy    retinitis    neuronitis    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: PPP1R2 (2 documents)

    Export disorders for PPP1R2 gene to outside databases

    Publications
    for PPP1R2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R2 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with PPP1R2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PubMed id 8119416)1, 2, 3, 9 Helps N.R.... Cohen P.T.W. (1994)
    2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PubMed id 9126490)1, 2, 3 Permana P.A. and Mott D.M. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. (PubMed id 7949733)1, 2 Sanseau P....Trowsdale J. (1994)
    6. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PubMed id 12393858)1, 9 Wang H. and Brautigan D.L. (2002)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for PPP1R2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PPP1R2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5504 HGNC: 9288 AceView: PPP1R2 Ensembl:ENSG00000184203 euGenes: HUgn5504
    ECgene: PPP1R2 H-InvDB: PPP1R2

    Other Databases showing PPP1R2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPP1R2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PPP1R2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPP1R2 gene:
    Search GeneIP for patents involving PPP1R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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