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Aliases for PPP1R2 Gene

Aliases for PPP1R2 Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 2 3 5
  • IPP-2 3 4
  • IPP2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2 2
  • Protein Phosphatase Inhibitor 2 3
  • Phosphoprotein Phosphatase 3

External Ids for PPP1R2 Gene

Previous GeneCards Identifiers for PPP1R2 Gene

  • GC03M194496
  • GC03M198627
  • GC03M196641
  • GC03M196560
  • GC03M196722
  • GC03M195241

Summaries for PPP1R2 Gene

Entrez Gene Summary for PPP1R2 Gene

  • Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PPP1R2 Gene

PPP1R2 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 2) is a Protein Coding gene. Diseases associated with PPP1R2 include Congenital Stationary Night Blindness. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R2P3.

UniProtKB/Swiss-Prot for PPP1R2 Gene

  • Inhibitor of protein-phosphatase 1.

Gene Wiki entry for PPP1R2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R2 Gene

Genomics for PPP1R2 Gene

Regulatory Elements for PPP1R2 Gene

Enhancers for PPP1R2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PPP1R2 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PPP1R2 Gene

Chromosome:
3
Start:
195,514,422 bp from pter
End:
195,543,401 bp from pter
Size:
28,980 bases
Orientation:
Minus strand

Genomic View for PPP1R2 Gene

Genes around PPP1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R2 Gene

Proteins for PPP1R2 Gene

  • Protein details for PPP1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41236-IPP2_HUMAN
    Recommended name:
    Protein phosphatase inhibitor 2
    Protein Accession:
    P41236

    Protein attributes for PPP1R2 Gene

    Size:
    205 amino acids
    Molecular mass:
    23015 Da
    Quaternary structure:
    • Heterodimer with PP1.

neXtProt entry for PPP1R2 Gene

Post-translational modifications for PPP1R2 Gene

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R2 Gene

No data available for DME Specific Peptides for PPP1R2 Gene

Domains & Families for PPP1R2 Gene

Gene Families for PPP1R2 Gene

Protein Domains for PPP1R2 Gene

Suggested Antigen Peptide Sequences for PPP1R2 Gene

Graphical View of Domain Structure for InterPro Entry

P41236

UniProtKB/Swiss-Prot:

IPP2_HUMAN :
  • Belongs to the protein phosphatase inhibitor 2 family.
Family:
  • Belongs to the protein phosphatase inhibitor 2 family.
genes like me logo Genes that share domains with PPP1R2: view

Function for PPP1R2 Gene

Molecular function for PPP1R2 Gene

GENATLAS Biochemistry:
protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence
UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.

Gene Ontology (GO) - Molecular Function for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004865 protein serine/threonine phosphatase inhibitor activity TAS 8119416
GO:0005515 protein binding IPI 10807923
genes like me logo Genes that share ontologies with PPP1R2: view
genes like me logo Genes that share phenotypes with PPP1R2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R2 Gene

Localization for PPP1R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R2 Gene COMPARTMENTS Subcellular localization image for PPP1R2 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IBA --
genes like me logo Genes that share ontologies with PPP1R2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R2 Gene

Pathways & Interactions for PPP1R2 Gene

genes like me logo Genes that share pathways with PPP1R2: view

Pathways by source for PPP1R2 Gene

SIGNOR curated interactions for PPP1R2 Gene

Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 9126490
GO:0009966 regulation of signal transduction IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0043666 regulation of phosphoprotein phosphatase activity IBA --
genes like me logo Genes that share ontologies with PPP1R2: view

Drugs & Compounds for PPP1R2 Gene

No Compound Related Data Available

Transcripts for PPP1R2 Gene

Unigene Clusters for PPP1R2 Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: -

Relevant External Links for PPP1R2 Gene

GeneLoc Exon Structure for
PPP1R2
ECgene alternative splicing isoforms for
PPP1R2

Expression for PPP1R2 Gene

mRNA expression in normal human tissues for PPP1R2 Gene

Protein differential expression in normal tissues from HIPED for PPP1R2 Gene

This gene is overexpressed in Lymph node (11.0) and Uterus (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PPP1R2 Gene:

PPP1R2

SOURCE GeneReport for Unigene cluster for PPP1R2 Gene:

Hs.535731
genes like me logo Genes that share expression patterns with PPP1R2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PPP1R2 Gene

Orthologs for PPP1R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R2 34
  • 88.78 (n)
  • 84.88 (a)
PPP1R2 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R2 34
  • 88.62 (n)
  • 83.41 (a)
PPP1R2 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r2 34
  • 85.69 (n)
  • 84.39 (a)
Ppp1r2 16
Ppp1r2 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R2 34
  • 99.51 (n)
  • 99.51 (a)
PPP1R2 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r2 34
  • 86.83 (n)
  • 84.88 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R2 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1R2 34
  • 70.86 (n)
  • 67.21 (a)
PPP1R2 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R2 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r2 34
  • 66.26 (n)
  • 67.28 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19508 34
ppp1r2 34
  • 62.61 (n)
  • 67.31 (a)
ppp1r2 35
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5774 34
fruit fly
(Drosophila melanogaster)
Insecta CG6380 35
  • 18 (a)
OneToMany
I-2 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.4 35
  • 35 (a)
OneToOne
Species where no ortholog for PPP1R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R2 Gene

ENSEMBL:
Gene Tree for PPP1R2 (if available)
TreeFam:
Gene Tree for PPP1R2 (if available)

Paralogs for PPP1R2 Gene

Paralogs for PPP1R2 Gene

(3) SIMAP similar genes for PPP1R2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPP1R2: view

Variants for PPP1R2 Gene

Sequence variations from dbSNP and Humsavar for PPP1R2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs860317 -- 195,537,041(+) CATTC(A/G)TAATT intron-variant
rs861098 -- 195,537,016(+) TAAAC(A/G)CAATC intron-variant
rs862064 -- 195,533,293(+) tgagc(A/T)gagat intron-variant
rs863727 -- 195,540,829(+) gaacc(A/G)taaga intron-variant
rs1136 -- 195,515,796(-) TAATT(A/C)GACTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP1R2 Gene

Variant ID Type Subtype PubMed ID
dgv5014n100 CNV gain 25217958
dgv5015n100 CNV loss 25217958
esv2759213 CNV gain+loss 17122850
esv2763776 CNV gain+loss 21179565
nsv1001387 CNV gain 25217958
nsv1006229 CNV gain 25217958
nsv428430 CNV gain+loss 18775914
nsv829824 CNV loss 17160897
nsv963395 CNV duplication 23825009

Variation tolerance for PPP1R2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R2 Gene

Disorders for PPP1R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP1R2

Human Genome Epidemiology (HuGE) Navigator
PPP1R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R2
genes like me logo Genes that share disorders with PPP1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R2 Gene

Publications for PPP1R2 Gene

  1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PMID: 8119416) Helps N.R. … Cohen P.T.W. (FEBS Lett. 1994) 2 3 4 22 65
  2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PMID: 9126490) Permana P.A. … Mott D.M. (Genomics 1997) 2 3 4 65
  3. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. (PMID: 23506001) Korrodi-GregA^rio L. … da Cruz E Silva E.F. (BMC Cell Biol. 2013) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 65

Products for PPP1R2 Gene

Sources for PPP1R2 Gene

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