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PPP1R2 Gene

protein-coding   GIFtS: 59
GCID: GC03M195241

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 21 2
IPP22 3 5
IPP-22 3
Phosphatase Inhibitor 22
Phosphoprotein Phosphatase2
Protein Phosphatase Inhibitor 22

External Ids:    HGNC: 92881   Entrez Gene: 55042   Ensembl: ENSG000001842037   OMIM: 6017925   UniProtKB: P412363   

Export aliases for PPP1R2 gene to outside databases

Previous GC identifers: GC03M194496 GC03M198627 GC03M196641 GC03M196560 GC03M196722


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPP1R2 Gene:
PPP1R2 (protein phosphatase 1, regulatory (inhibitor) subunit 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity.

UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
Function: Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   HTF   Max   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R2 promoter sequence
   Search Chromatin IP Primers for PPP1R2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195241:  view genomic region     (about GC identifiers)

Start:
195,241,221 bp from pter      End:
195,270,224 bp from pter
Size:
29,004 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236 (See protein sequence)
Recommended Name: Protein phosphatase inhibitor 2  
Size: 205 amino acids; 23015 Da
Subunit: Heterodimer with PP1

Explore the universe of human proteins at neXtProt for PPP1R2: NX_P41236

Explore proteomics data for PPP1R2 at MOPED

Post-translational modifications: 

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity).
    Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006232.1  
    ENSEMBL proteins: 
     ENSP00000328178   ENSP00000415175   ENSP00000400238   ENSP00000406725  

    PPP1R2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PPP1R2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR007062 PPI-2

    Graphical View of Domain Structure for InterPro Entry P41236

    ProtoNet protein and cluster: P41236

    1 Blocks protein domain: IPB007062 Protein phosphatase inhibitor 2 (IPP-2)

    UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
    Similarity: Belongs to the protein phosphatase inhibitor 2 family


    Find genes that share domains with PPP1R2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPP2_HUMAN, P41236
    Function: Inhibitor of protein-phosphatase 1

         Genatlas biochemistry entry for PPP1R2:
    protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity ----
    GO:0004865protein serine/threonine phosphatase inhibitor activity TAS8119416
    GO:0005515protein binding IPI10807923
         
    Find genes that share ontologies with PPP1R2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP1R2:
     Decreased focal adhesion (FA)   Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1R2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1R2

    miRNA
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    miRTarBase miRNAs that target PPP1R2:
    hsa-mir-375 (MIRT019980), hsa-let-7e-5p (MIRT051667)

    Block miRNA regulation of human, mouse, rat PPP1R2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1R2 (see all 51):
    hsa-miR-2052 hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-30d hsa-miR-374a hsa-miR-4275 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1R2

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    GenScript: all cDNA clones in your preferred vector: PPP1R2 (NM_006241)
    Sino Biological Human cDNA Clone for PPP1R2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    4ERK Signaling
    ERK Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R2 (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R2
        Insulin Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP1R2
    Interactions:

        Search GeneGlobe Interaction Network for PPP1R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1R2 (P412361, 2, 3 ENSP000003281784) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CCP368731, 2, 3, ENSP000003350844EBI-1056517,EBI-356283 MINT-8286998 MINT-8287012 MINT-8287084 I2D: score=3 STRING: ENSP00000335084
    PPP1CAP621361, 2, 3, ENSP000003260314EBI-1056517,EBI-357253 MINT-8287028 I2D: score=2 STRING: ENSP00000326031
    GSK3BP498412, 3, ENSP000003248064MINT-8286998 MINT-8287012 I2D: score=2 STRING: ENSP00000324806
    LMTK2Q8IWU21, 3, ENSP000002972934EBI-1056517,EBI-2008933 I2D: score=4 STRING: ENSP00000297293
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--
    GO:0006091generation of precursor metabolites and energy TAS9126490
    GO:0009966regulation of signal transduction IEA--
    GO:0043086negative regulation of catalytic activity TAS8119416
    GO:0043666regulation of phosphoprotein phosphatase activity IEA--

    Find genes that share ontologies with PPP1R2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R2 (IPP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1R2 gene: 
    NM_006241.6  

    Unigene Cluster for PPP1R2:

    Protein phosphatase 1, regulatory (inhibitor) subunit 2
    Hs.535731  [show with all ESTs]
    Unigene Representative Sequence: NM_006241
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328432(uc003fup.3) ENST00000418939 ENST00000460437 ENST00000438848
    ENST00000413183 ENST00000462906(uc003fuq.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPP1R2 (see all 51):
    hsa-miR-2052 hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-30d hsa-miR-374a hsa-miR-4275 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R2 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PPP1R2
      QuantiTect SYBR Green Assays in human, mouse, rat PPP1R2
      QuantiFast Probe-based Assays in human, mouse, rat PPP1R2

    Additional mRNA sequence: 

    AJ133812.1 AK124014.1 AY063767.1 BC007655.2 BC066921.1 X78873.1 Z29646.1 

    13 DOTS entries:

    DT.449863  DT.95205535  DT.92439339  DT.99938577  DT.99945124  DT.95205533  DT.100794138  DT.100794145 
    DT.92439342  DT.100046027  DT.100794141  DT.100794146  DT.95205531 

    Selected AceView cDNA sequences (see all 228):

    AA398194 AA169809 F01854 AI141367 AW768697 AW269594 BM970356 BM508171 
    AI128684 BE274900 BQ632564 AI308762 AW591077 AI361987 BM510352 BM698624 
    AI278530 AA188658 CA448179 AI638626 AI304781 AY063767 AA452584 F05004 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                          -                           
    SP3:                                -                     


    ECgene alternative splicing isoforms for PPP1R2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGGTTT
    PPP1R2 Expression
    About this image


    PPP1R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
    PPP1R2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535731
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    QuantiFast Probe-based Assays in human, mouse, rat PPP1R2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r21 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 85.69(n)1
    84.39(a)1
      16 (21.41 cM)5
    668491  NM_025800.31  NP_080076.11 
     312515375 
    chicken
    (Gallus gallus)
    Aves PPP1R21 protein phosphatase 1, regulatory (inhibitor) subunit more 70.86(n)
    67.21(a)
      424894  NM_001031313.1  NP_001026484.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R26
    protein phosphatase 1, regulatory (inhibitor) subu...
    57(a)
    1 ↔ 1
    AAWZ02038515(2651-6078)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppp1r21 protein phosphatase 1, regulatory (inhibitor) subunit more 66.26(n)
    67.28(a)
      100038193  NM_001170496.1  NP_001163967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.195082 Transcribed sequence with weak similarity to protein more 72.63(n)    CK360410.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta I-26
    CG63806
    --
    22(a)
    18(a)
    many → 1
    many → 1
    3L(9827467-9829905)
    2L(17291134-17292202)
    worm
    (Caenorhabditis elegans)
    Secernentea Y32H12A.46
    Protein Y32H12A.4 (Y32H12A.4) mRNA, complete cds
    35(a)
    1 ↔ 1
    III(5369055-5372316) WBGene00021312


    ENSEMBL Gene Tree for PPP1R2 (if available)
    TreeFam Gene Tree for PPP1R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R2 gene
    3 SIMAP similar genes for PPP1R2 using alignment to 5 protein entries:     IPP2_HUMAN (see all proteins):
    PPP1R2P1    PPP1R2P3    PPP1R2P9

    Find genes that share paralogs with PPP1R2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PPP1R2 (see all 11)
    PGOHUM00000248417 PGOHUM00000237216 PGOHUM00000239168 PGOHUM00000240239 PGOHUM00000243152


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R2 (see all 670)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756909351,2
    C,F--195240743(+) ACTGCA/TAACAA 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1838380481,2
    --195240819(+) TACTCC/TTAAAG 1 -- int10--------
    rs738908381,2
    C,F--195240869(+) AGGTAC/TAATTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1474170791,2
    --195240902(+) AAATGC/TATGAA 1 -- int10--------
    rs1484448971,2
    --195241087(+) CACAAC/TGCTAC 1 -- int10--------
    rs1427078841,2
    C--195241115(+) CTCGGC/TCACAG 1 -- int10--------
    rs1505818791,2
    --195241170(+) GGATTA/TTGGTC 1 -- int10--------
    rs1396116231,2
    --195241187(+) TAGCTA/GAGTAA 1 -- int10--------
    rs1883335671,2
    --195241234(+) TTATTA/GTATTT 1 -- ut310--------
    rs1932604201,2
    --195241273(+) TGAAAA/GGGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP1R2 (195241221 - 195270224 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PPP1R2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829824CNV Loss17160897
    nsv878145CNV Gain21882294
    nsv878138CNV Gain21882294
    nsv428430CNV Gain+Loss18775914
    dgv1549e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601792    OMIM disorders: --


    Find genes that share disorders with PPP1R2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: PPP1R2 (2 documents)

    Export disorders for PPP1R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R2 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with PPP1R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PubMed id 8119416)1, 2, 3, 9 Helps N.R.... Cohen P.T.W. (FEBS Lett. 1994)
    2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PubMed id 9126490)1, 2, 3 Permana P.A. and Mott D.M. (Genomics 1997)
    3. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. (PubMed id 23506001)1, 2 Korrodi-GregA^rio L....da Cruz E Silva E.F. (BMC Cell Biol. 2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. (PubMed id 7949733)1, 2 Sanseau P.... Trowsdale J. (Mamm. Genome 1994)
    7. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PubMed id 12393858)1, 9 Wang H. and Brautigan D.L. (J. Biol. Chem. 2002)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes. (PubMed id 24195737)1 Korrodi-GregA^rio L....Esteves P.J. (BMC Evol. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5504 HGNC: 9288 AceView: PPP1R2 Ensembl:ENSG00000184203 euGenes: HUgn5504
    ECgene: PPP1R2 H-InvDB: PPP1R2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R2 gene:
    Search GeneIP for patents involving PPP1R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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