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Aliases for PPP1R2 Gene

Aliases for PPP1R2 Gene

  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2 2 3
  • IPP2 3 4 6
  • IPP-2 3 4
  • Protein Phosphatase Inhibitor 2 3
  • Phosphoprotein Phosphatase 3

External Ids for PPP1R2 Gene

Previous GeneCards Identifiers for PPP1R2 Gene

  • GC03M194496
  • GC03M198627
  • GC03M196641
  • GC03M196560
  • GC03M196722
  • GC03M195241

Summaries for PPP1R2 Gene

GeneCards Summary for PPP1R2 Gene

PPP1R2 (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R2 Gene

  • Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R2 Gene

Genomics for PPP1R2 Gene

Regulatory Elements for PPP1R2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1R2 Gene

Start:
195,514,425 bp from pter
End:
195,543,401 bp from pter
Size:
28,977 bases
Orientation:
Minus strand

Genomic View for PPP1R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R2 Gene

Proteins for PPP1R2 Gene

  • Protein details for PPP1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41236-IPP2_HUMAN
    Recommended name:
    Protein phosphatase inhibitor 2
    Protein Accession:
    P41236
    Secondary Accessions:

    Protein attributes for PPP1R2 Gene

    Size:
    205 amino acids
    Molecular mass:
    23015 Da
    Quaternary structure:
    • Heterodimer with PP1.

neXtProt entry for PPP1R2 Gene

Proteomics data for PPP1R2 Gene at MOPED

Post-translational modifications for PPP1R2 Gene

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R2 Gene

Antibody Products

  • R&D Systems Antibodies for PPP1R2 (PP1 Inhibitor-2)

No data available for DME Specific Peptides for PPP1R2 Gene

Domains for PPP1R2 Gene

Gene Families for PPP1R2 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R2 Gene

Suggested Antigen Peptide Sequences for PPP1R2 Gene

Graphical View of Domain Structure for InterPro Entry

P41236

UniProtKB/Swiss-Prot:

IPP2_HUMAN :
  • P41236
Family:
  • Belongs to the protein phosphatase inhibitor 2 family.
genes like me logo Genes that share domains with PPP1R2: view

Function for PPP1R2 Gene

Molecular function for PPP1R2 Gene

GENATLAS Biochemistry: protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence
UniProtKB/Swiss-Prot Function: Inhibitor of protein-phosphatase 1

Gene Ontology (GO) - Molecular Function for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity --
GO:0004865 protein serine/threonine phosphatase inhibitor activity TAS 8119416
GO:0005515 protein binding IPI 10807923
genes like me logo Genes that share ontologies with PPP1R2: view

Phenotypes for PPP1R2 Gene

GenomeRNAi human phenotypes for PPP1R2:
genes like me logo Genes that share phenotypes with PPP1R2: view

Animal Model Products

CRISPR Products

miRNA for PPP1R2 Gene

miRTarBase miRNAs that target PPP1R2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1R2 Gene

Localization for PPP1R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R2 Gene COMPARTMENTS Subcellular localization image for PPP1R2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R2 Gene

Pathways for PPP1R2 Gene

genes like me logo Genes that share pathways with PPP1R2: view

Pathways by source for PPP1R2 Gene

Gene Ontology (GO) - Biological Process for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 9126490
GO:0009966 regulation of signal transduction IEA --
GO:0043086 negative regulation of catalytic activity TAS 8119416
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R2: view

Transcripts for PPP1R2 Gene

Unigene Clusters for PPP1R2 Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: -

Relevant External Links for PPP1R2 Gene

GeneLoc Exon Structure for
PPP1R2
ECgene alternative splicing isoforms for
PPP1R2

Expression for PPP1R2 Gene

mRNA expression in normal human tissues for PPP1R2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PPP1R2 Gene

SOURCE GeneReport for Unigene cluster for PPP1R2 Gene Hs.535731

genes like me logo Genes that share expressions with PPP1R2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R2 Gene

Orthologs for PPP1R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R2 35
  • 99.51 (n)
  • 99.51 (a)
PPP1R2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R2 35
  • 88.78 (n)
  • 84.88 (a)
PPP1R2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R2 35
  • 88.62 (n)
  • 83.41 (a)
PPP1R2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r2 35
  • 85.69 (n)
  • 84.39 (a)
Ppp1r2 16
Ppp1r2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r2 35
  • 86.83 (n)
  • 84.88 (a)
chicken
(Gallus gallus)
Aves PPP1R2 35
  • 70.86 (n)
  • 67.21 (a)
PPP1R2 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r2 35
  • 66.26 (n)
  • 67.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5774 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19508 35
ppp1r2 35
  • 62.61 (n)
  • 67.31 (a)
ppp1r2 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6380 36
  • 18 (a)
OneToMany
I-2 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.4 36
  • 35 (a)
OneToOne
Species with no ortholog for PPP1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R2 Gene

ENSEMBL:
Gene Tree for PPP1R2 (if available)
TreeFam:
Gene Tree for PPP1R2 (if available)

Paralogs for PPP1R2 Gene

Selected SIMAP similar genes for PPP1R2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPP1R2: view

No data available for Paralogs for PPP1R2 Gene

Variants for PPP1R2 Gene

Sequence variations from dbSNP and Humsavar for PPP1R2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1136 -- 195,515,796(-) TAATT(A/C)GACTT utr-variant-3-prime
rs9414 -- 195,516,693(-) GTACT(A/T)TACCA utr-variant-3-prime
rs9935 -- 195,514,604(+) TTTTA(A/G)ACAAA utr-variant-3-prime
rs11475 -- 195,543,189(-) CGTTG(C/T)GTCGT utr-variant-5-prime
rs823507 -- 195,534,847(+) agcca(C/T)gtgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R2 Gene

Variant ID Type Subtype PubMed ID
nsv878138 CNV Gain 21882294
dgv1549e1 CNV Complex 17122850
nsv829824 CNV Loss 17160897
nsv428430 CNV Gain+Loss 18775914
nsv878145 CNV Gain 21882294

Relevant External Links for PPP1R2 Gene

HapMap Linkage Disequilibrium report
PPP1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R2 Gene

Disorders for PPP1R2 Gene

Relevant External Links for PPP1R2

Human Genome Epidemiology (HuGE) Navigator
PPP1R2
genes like me logo Genes that share disorders with PPP1R2: view

No data available for UniProtKB/Swiss-Prot for PPP1R2 Gene

Publications for PPP1R2 Gene

  1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PMID: 8119416) Helps N.R. … Cohen P.T.W. (FEBS Lett. 1994) 2 3 4 23
  2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PMID: 9126490) Permana P.A. … Mott D.M. (Genomics 1997) 2 3 4
  3. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PMID: 12393858) Wang H. … Brautigan D.L. (J. Biol. Chem. 2002) 3 23
  4. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. (PMID: 7949733) Sanseau P. … Trowsdale J. (Mamm. Genome 1994) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPP1R2 Gene

Sources for PPP1R2 Gene

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