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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R2 Gene

protein-coding   GIFtS: 59
GCID: GC03M195241

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 21 2
IPP22 3 5
IPP-22 3
Phosphatase Inhibitor 22
Phosphoprotein Phosphatase2
Protein Phosphatase Inhibitor 22

External Ids:    HGNC: 92881   Entrez Gene: 55042   Ensembl: ENSG000001842037   OMIM: 6017925   UniProtKB: P412363   

Export aliases for PPP1R2 gene to outside databases

Previous GC identifers: GC03M194496 GC03M198627 GC03M196641 GC03M196560 GC03M196722


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPP1R2 Gene: 
PPP1R2 (protein phosphatase 1, regulatory (inhibitor) subunit 2) is a protein-coding gene. Diseases associated with PPP1R2 include congenital stationary night blindness, and night blindness, and among its related super-pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include protein binding and protein serine/threonine phosphatase inhibitor activity.

UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
Function: Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   HTF   Max   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195241:  view genomic region     (about GC identifiers)

Start:
195,241,221 bp from pter      End:
195,270,224 bp from pter
Size:
29,004 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236 (See protein sequence)
Recommended Name: Protein phosphatase inhibitor 2  
Size: 205 amino acids; 23015 Da
Subunit: Heterodimer with PP1

Explore the universe of human proteins at neXtProt for PPP1R2: NX_P41236

Explore proteomics data for PPP1R2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity).
    Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41236

  • PPP1R2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP1R2 Protein Expression
    REFSEQ proteins: NP_006232.1  
    ENSEMBL proteins: 
     ENSP00000328178   ENSP00000415175   ENSP00000400238   ENSP00000406725  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR007062 PPI-2

    Graphical View of Domain Structure for InterPro Entry P41236

    ProtoNet protein and cluster: P41236

    1 Blocks protein domain: IPB007062 Protein phosphatase inhibitor 2 (IPP-2)

    UniProtKB/Swiss-Prot: IPP2_HUMAN, P41236
    Similarity: Belongs to the protein phosphatase inhibitor 2 family


    PPP1R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPP2_HUMAN, P41236
    Function: Inhibitor of protein-phosphatase 1

         Genatlas biochemistry entry for PPP1R2:
    protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity ----
    GO:0004865protein serine/threonine phosphatase inhibitor activity TAS8119416
    GO:0005515protein binding IPI10807923
         
    PPP1R2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP1R2:
     Decreased focal adhesion (FA)   Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP1R2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R2 
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    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R2 (see all 51):
    hsa-miR-2052 hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-30d hsa-miR-374a hsa-miR-4275 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP1R2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    4Rho Family GTPases
    ERK Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R2 (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R2
        Insulin Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP1R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for PPP1R2 (P412361, 2, 3 ENSP000003281784) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CCP368732, 3, ENSP000003350844MINT-8286998 MINT-8287012 MINT-8287084 I2D: score=3 STRING: ENSP00000335084
    GSK3BP498412, 3, ENSP000003248064MINT-8286998 MINT-8287012 I2D: score=2 STRING: ENSP00000324806
    LMTK2Q8IWU21, 3, ENSP000002972934EBI-1056517,EBI-2008933 I2D: score=4 STRING: ENSP00000297293
    PPP1CAP621362, 3, ENSP000003260314MINT-8287028 I2D: score=2 STRING: ENSP00000326031
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--
    GO:0006091generation of precursor metabolites and energy TAS9126490
    GO:0009966regulation of signal transduction IEA--
    GO:0043666regulation of phosphoprotein phosphatase activity IEA--

    PPP1R2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R2 (IPP2)

    Search CenterWatch for drugs/clinical trials and news about PPP1R2 / IPP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP1R2 gene: 
    NM_006241.4  

    Unigene Clusters for PPP1R2:

    Protein phosphatase 1, regulatory (inhibitor) subunit 2
    Hs.535731  [show with all ESTs], Hs.706920  [show with all ESTs]
    Unigene Representative Sequences: NM_006241, CF552101
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328432(uc003fup.3) ENST00000418939 ENST00000460437 ENST00000438848
    ENST00000413183 ENST00000462906(uc003fuq.4)
    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R2 (see all 51):
    hsa-miR-2052 hsa-miR-548j hsa-miR-582-3p hsa-miR-300 hsa-miR-30d hsa-miR-374a hsa-miR-4275 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R2
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    Additional mRNA sequence: Y13810.1 

    13 DOTS entries:

    DT.449863  DT.95205535  DT.92439339  DT.99938577  DT.99945124  DT.95205533  DT.100794138  DT.100794145 
    DT.92439342  DT.100046027  DT.100794141  DT.100794146  DT.95205531 

    24/228 AceView cDNA sequences (see all 228):

    BX111624 AI361987 AI304781 BQ632564 F05004 AI638626 AI290075 AI338217 
    AW269594 X78873 AA987517 BX486126 BE274900 AW071522 BQ788100 AI760333 
    CR619030 CA448179 Z29646 AI424751 CB242116 BF115113 AU126913 AI271849 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                          -                           
    SP3:                                -                     


    ECgene alternative splicing isoforms for PPP1R2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R2 expression in normal human tissues (normalized intensities)      PPP1R2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGGTTT
    PPP1R2 Expression
    About this image


    PPP1R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius muscle   

    See PPP1R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R2

    SOURCE GeneReport for Unigene clusters: Hs.535731 Hs.706920
        SABiosciences Custom PCR Arrays for PPP1R2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r21 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 85.69(n)1
    84.39(a)1
      16 (21.41 cM)5
    668491  NM_025800.31  NP_080076.11 
     312515375 
    chicken
    (Gallus gallus)
    Aves PPP1R21 protein phosphatase 1, regulatory (inhibitor) subunit more 68.4(n)
    63.54(a)
      424894  NM_001031313.1  NP_001026484.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R26
    Uncharacterized protein
    55(a)
    1 ↔ 1
    AAWZ02038515(2651-6078)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.195082 Transcribed sequence with weak similarity to protein more 72.63(n)    CK360410.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63806
    I-26
    Inhibitor-2
    20(a)
    20(a)
    many → 1
    many → 1
    2L(17291134-17292202)
    3L(9827467-9829905)
    worm
    (Caenorhabditis elegans)
    Secernentea Y32H12A.41 Protein Y32H12A.4 49.33(n)
    41.04(a)
      175738  NM_065746.2  NP_498147.1 


    ENSEMBL Gene Tree for PPP1R2 (if available)
    TreeFam Gene Tree for PPP1R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R2 gene
    3 SIMAP similar genes for PPP1R2 using alignment to 5 protein entries:     IPP2_HUMAN (see all proteins):
    PPP1R2P1    PPP1R2P3    PPP1R2P9

    PPP1R2 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for PPP1R2 (see all 11)
    PGOHUM00000248417 PGOHUM00000237216 PGOHUM00000239168 PGOHUM00000240239 PGOHUM00000243152


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/670 SNPs in PPP1R2 are shown (see all 670)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756909351,2
    C,F--195240743(+) ACTGCA/TAACAA 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1838380481,2
    --195240819(+) TACTCC/TTAAAG 1 -- int10--------
    rs738908381,2
    C,F--195240869(+) AGGTAC/TAATTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1474170791,2
    --195240902(+) AAATGC/TATGAA 1 -- int10--------
    rs1484448971,2
    --195241087(+) CACAAC/TGCTAC 1 -- int10--------
    rs1427078841,2
    C--195241115(+) CTCGGC/TCACAG 1 -- int10--------
    rs1505818791,2
    --195241170(+) GGATTA/TTGGTC 1 -- int10--------
    rs1396116231,2
    --195241187(+) TAGCTA/GAGTAA 1 -- int10--------
    rs1883335671,2
    --195241234(+) TTATTA/GTATTT 1 -- ut310--------
    rs1932604201,2
    --195241273(+) TGAAAA/GGGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP1R2 (195241221 - 195270224 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PPP1R2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829824CNV Loss17160897
    nsv878145CNV Gain21882294
    nsv878138CNV Gain21882294
    nsv428430CNV Gain+Loss18775914
    dgv1549e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601792    OMIM disorders: --

    7 diseases for PPP1R2:    About MalaCards
    congenital stationary night blindness    night blindness    blindness    insulin resistance
    retinitis    breast cancer    neuronitis


    PPP1R2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: PPP1R2 (2 documents)

    Export disorders for PPP1R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R2 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with PPP1R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PubMed id 8119416)1, 2, 3, 9 Helps N.R.... Cohen P.T.W. (1994)
    2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PubMed id 9126490)1, 2, 3 Permana P.A. and Mott D.M. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. (PubMed id 7949733)1, 2 Sanseau P....Trowsdale J. (1994)
    6. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PubMed id 12393858)1, 9 Wang H. and Brautigan D.L. (2002)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. Identification and characterization of two distinct PP P1R2 isoforms in human spermatozoa. (PubMed id 23506001)1 Korrodi-Gregorio L....da Cruz E Silva E.F. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5504 HGNC: 9288 AceView: PPP1R2 Ensembl:ENSG00000184203 euGenes: HUgn5504
    ECgene: PPP1R2 H-InvDB: PPP1R2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1R2 gene:
    Search GeneIP for patents involving PPP1R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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