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Aliases for PPP1R2 Gene

Aliases for PPP1R2 Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2 2 3
  • IPP-2 3 4
  • IPP2 3 4
  • Phosphoprotein Phosphatase 3

External Ids for PPP1R2 Gene

Previous GeneCards Identifiers for PPP1R2 Gene

  • GC03M194496
  • GC03M198627
  • GC03M196641
  • GC03M196560
  • GC03M196722
  • GC03M195241

Summaries for PPP1R2 Gene

Entrez Gene Summary for PPP1R2 Gene

  • Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PPP1R2 Gene

PPP1R2 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 2) is a Protein Coding gene. Diseases associated with PPP1R2 include Congenital Stationary Night Blindness. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R2 Gene

  • Inhibitor of protein-phosphatase 1.

Gene Wiki entry for PPP1R2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R2 Gene

Genomics for PPP1R2 Gene

Regulatory Elements for PPP1R2 Gene

Enhancers for PPP1R2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R2 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R2 Gene

195,514,422 bp from pter
195,543,401 bp from pter
28,980 bases
Minus strand

Genomic View for PPP1R2 Gene

Genes around PPP1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R2 Gene

Proteins for PPP1R2 Gene

  • Protein details for PPP1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase inhibitor 2
    Protein Accession:

    Protein attributes for PPP1R2 Gene

    205 amino acids
    Molecular mass:
    23015 Da
    Quaternary structure:
    • Heterodimer with PP1.

neXtProt entry for PPP1R2 Gene

Proteomics data for PPP1R2 Gene at MOPED

Post-translational modifications for PPP1R2 Gene

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R2 Gene

No data available for DME Specific Peptides for PPP1R2 Gene

Domains & Families for PPP1R2 Gene

Gene Families for PPP1R2 Gene

Protein Domains for PPP1R2 Gene

Suggested Antigen Peptide Sequences for PPP1R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein phosphatase inhibitor 2 family.
  • Belongs to the protein phosphatase inhibitor 2 family.
genes like me logo Genes that share domains with PPP1R2: view

Function for PPP1R2 Gene

Molecular function for PPP1R2 Gene

GENATLAS Biochemistry:
protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence
UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.
genes like me logo Genes that share phenotypes with PPP1R2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R2 Gene

Localization for PPP1R2 Gene

Subcellular locations from

Jensen Localization Image for PPP1R2 Gene COMPARTMENTS Subcellular localization image for PPP1R2 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R2 Gene

Pathways & Interactions for PPP1R2 Gene

genes like me logo Genes that share pathways with PPP1R2: view

Pathways by source for PPP1R2 Gene

SIGNOR curated interactions for PPP1R2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9126490
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with PPP1R2: view

Drugs & Compounds for PPP1R2 Gene

No Compound Related Data Available

Transcripts for PPP1R2 Gene

Unigene Clusters for PPP1R2 Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: -
SP3: -

Relevant External Links for PPP1R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R2 Gene

mRNA expression in normal human tissues for PPP1R2 Gene

Protein differential expression in normal tissues from HIPED for PPP1R2 Gene

This gene is overexpressed in Lymph node (11.0) and Uterus (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PPP1R2 Gene

SOURCE GeneReport for Unigene cluster for PPP1R2 Gene Hs.535731

genes like me logo Genes that share expression patterns with PPP1R2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPP1R2 Gene

Orthologs for PPP1R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R2 35
  • 88.78 (n)
  • 84.88 (a)
PPP1R2 36
  • 85 (a)
(Canis familiaris)
Mammalia PPP1R2 35
  • 88.62 (n)
  • 83.41 (a)
PPP1R2 36
  • 83 (a)
(Mus musculus)
Mammalia Ppp1r2 35
  • 85.69 (n)
  • 84.39 (a)
Ppp1r2 16
Ppp1r2 36
  • 84 (a)
(Pan troglodytes)
Mammalia PPP1R2 35
  • 99.51 (n)
  • 99.51 (a)
PPP1R2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Ppp1r2 35
  • 86.83 (n)
  • 84.88 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
-- 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R2 36
  • 74 (a)
(Gallus gallus)
Aves PPP1R2 35
  • 70.86 (n)
  • 67.21 (a)
PPP1R2 36
  • 52 (a)
(Anolis carolinensis)
Reptilia PPP1R2 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r2 35
  • 66.26 (n)
  • 67.28 (a)
(Danio rerio)
Actinopterygii Dr.19508 35
ppp1r2 35
  • 62.61 (n)
  • 67.31 (a)
ppp1r2 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5774 35
fruit fly
(Drosophila melanogaster)
Insecta CG6380 36
  • 18 (a)
I-2 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea Y32H12A.4 36
  • 35 (a)
Species with no ortholog for PPP1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R2 Gene

Gene Tree for PPP1R2 (if available)
Gene Tree for PPP1R2 (if available)

Paralogs for PPP1R2 Gene

(3) SIMAP similar genes for PPP1R2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPP1R2: view

No data available for Paralogs for PPP1R2 Gene

Variants for PPP1R2 Gene

Sequence variations from dbSNP and Humsavar for PPP1R2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1136 -- 195,515,796(-) TAATT(A/C)GACTT utr-variant-3-prime
rs9414 -- 195,516,693(-) GTACT(A/T)TACCA utr-variant-3-prime
rs9935 -- 195,514,604(+) TTTTA(A/G)ACAAA utr-variant-3-prime
rs11475 -- 195,543,189(-) CGTTG(C/T)GTCGT utr-variant-5-prime
rs1051824 -- 195,516,355(-) ACTAT(C/T)TTTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP1R2 Gene

Variant ID Type Subtype PubMed ID
nsv878138 CNV Gain 21882294
dgv1549e1 CNV Complex 17122850
nsv829824 CNV Loss 17160897
nsv428430 CNV Gain+Loss 18775914
nsv878145 CNV Gain 21882294

Variation tolerance for PPP1R2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R2 Gene

Disorders for PPP1R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP1R2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPP1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R2 Gene

Publications for PPP1R2 Gene

  1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PMID: 8119416) Helps N.R. … Cohen P.T.W. (FEBS Lett. 1994) 2 3 4 23 67
  2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PMID: 12393858) Wang H. … Brautigan D.L. (J. Biol. Chem. 2002) 3 23
  3. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PMID: 9126490) Permana P.A. … Mott D.M. (Genomics 1997) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PPP1R2 Gene

Sources for PPP1R2 Gene