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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R1B Gene

protein-coding   GIFtS: 64
GCID: GC17P037783

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B1 2     Dopamine And CAMP-Regulated Neuronal Phosphoprotein 322
DARPP-322 3     Protein Phosphatase 1 Regulatory Subunit 1B2
DARPP322 3     Dopamine- And CAMP-Regulated Neuronal Phosphoprotein3
Dopamine And CAMP Regulated Phosphoprotein1     

External Ids:    HGNC: 92871   Entrez Gene: 841522   Ensembl: ENSG000001317717   OMIM: 6043995   UniProtKB: Q9UD713   

Export aliases for PPP1R1B gene to outside databases

Previous GC identifers: GC17P037283 GC17P039780 GC17P037693 GC17P038158 GC17P035036 GC17P033576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R1B Gene:
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation
regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this
gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for PPP1R1B Gene: 
PPP1R1B (protein phosphatase 1, regulatory (inhibitor) subunit 1B) is a protein-coding gene. Diseases associated with PPP1R1B include nicotine dependence, and gastric adenocarcinoma, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase inhibitor activity and receptor binding.

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71
Function: Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R1B gene promoter:
         CREB   Sp1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1R1B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R1B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037783:  view genomic region     (about GC identifiers)

Start:
37,782,993 bp from pter      End:
37,792,879 bp from pter
Size:
9,887 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 1B  
Size: 204 amino acids; 22963 Da
Subcellular location: Cytoplasm
Secondary accessions: Q547V9 Q547W0 Q9H7G1
Alternative splicing: 2 isoforms:  Q9UD71-1   Q9UD71-2   

Explore the universe of human proteins at neXtProt for PPP1R1B: NX_Q9UD71

Explore proteomics data for PPP1R1B at MOPED 

Post-translational modifications:

  • UniProtKB: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein
  • UniProtKB: Phosphorylation of Thr-34 is required for activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UD71

  • PPP1R1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP1R1B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001229393.1  NP_115568.2  NP_852606.1  

    ENSEMBL proteins: 
     ENSP00000462137   ENSP00000254079   ENSP00000462522   ENSP00000462841   ENSP00000377808  
     ENSP00000377810  
    Reactome Protein details: Q9UD71
    Human Recombinant Protein Products for PPP1R1B: 
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    Novus Biologicals PPP1R1B Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPP1R1B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--
    GO:0043025neuronal cell body IEA--

    PPP1R1B for ontologies           About GeneDecksing



    PPP1R1B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    2 InterPro protein domains:
     IPR015670 Dopamine/cAMP_neuron_P-prot
     IPR008466 PPI_1DARPP-32

    Graphical View of Domain Structure for InterPro Entry Q9UD71

    ProtoNet protein and cluster: Q9UD71

    1 Blocks protein domain: IPB008466 Protein phosphatase inhibitor

    UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71
    Similarity: Belongs to the protein phosphatase inhibitor 1 family


    PPP1R1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPR1B_HUMAN, Q9UD71
    Function: Inhibitor of protein-phosphatase 1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity TAS10604473
    GO:0004864protein phosphatase inhibitor activity TAS10604473
    GO:0005102receptor binding IEA--
    GO:0008599protein phosphatase type 1 regulator activity TAS--
         
    PPP1R1B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP1R1B:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Stronger migration 

         3 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ppp1r1b):
     behavior/neurological  homeostasis/metabolism  nervous system 

    PPP1R1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp1r1btm1Aaf for PPP1R1B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP1R1B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R1B 
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    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R1B (see all 13):
    hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-3175 hsa-miR-3157-5p hsa-miR-221* hsa-miR-2355-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R1B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP1R1B About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    5Ca-dependent events
    Opioid Signalling0.55
    DARPP-32 events0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PPP1R1B
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction PKA signaling

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R1B (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    2 Cell Signaling Technology (CST) Pathways for PPP1R1B
        Ca, cAMP and Lipid Signaling
    Neuroscience

    1 Tocris Bioscience Pathway for PPP1R1B
        Insulin Pathway

    2 GeneGo (Thomson Reuters) Pathways for PPP1R1B
        Signal transduction PKA signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for PPP1R1B
        Nicotine Activity on Dopaminergic Neurons

    4        Reactome Pathways for PPP1R1B
        DARPP-32 events
    Signal Transduction
    Signaling by GPCR
    Opioid Signalling

    1 PharmGKB Pathway for PPP1R1B
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    4         Kegg Pathways  (Kegg details for PPP1R1B):
        Dopaminergic synapse
    Cocaine addiction
    Amphetamine addiction
    Alcoholism


    PPP1R1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/17 Interacting proteins for PPP1R1B (Q9UD712, 3 ENSP000002540794) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROBO2Q9HCK42, 3MINT-65696 I2D: score=3 
    CDK5Q005353, ENSP000002975184I2D: score=1 STRING: ENSP00000297518
    CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
    PPP1CAP621363, ENSP000003260314I2D: score=1 STRING: ENSP00000326031
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006469negative regulation of protein kinase activity TAS10604473
    GO:0007165signal transduction TAS10604473
    GO:0007621negative regulation of female receptivity IEA--

    PPP1R1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP1R1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R1B (PPR1B)

    3 HMDB Compounds for PPP1R1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/15 Novoseek inferred chemical compound relationships for PPP1R1B gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 78.3 91 1663529 (3), 17194217 (3), 16965177 (3), 17948899 (2) (see all 55)
    okadaic acid 38.1 1 9606178 (1)
    glutamate 34.4 12 17194217 (3), 12538871 (2), 9483560 (2), 8248241 (1) (see all 6)
    threonine 32 3 15464122 (1), 9108011 (1), 16353915 (1)
    cyclic amp 19.7 2 1975775 (1), 8298087 (1)
    tyrosine 17.2 9 1971224 (2), 9483560 (2), 1975775 (1), 19254752 (1) (see all 6)
    serine 16.8 3 15464122 (1), 14744247 (1), 16353915 (1)
    nicotine 16.1 9 16040813 (4), 17171661 (2)
    forskolin 9.36 3 9606178 (2), 12538871 (1)
    nmda 6.68 1 16764827 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP1R1B / PPR1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP1R1B gene (3 alternative transcripts): 
    NM_001242464.1  NM_032192.3  NM_181505.3  

    Unigene Cluster for PPP1R1B:

    Protein phosphatase 1, regulatory (inhibitor) subunit 1B
    Hs.286192  [show with all ESTs]
    Unigene Representative Sequence: AK123950
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580825 ENST00000254079(uc002hrz.3 uc010cvx.3) ENST00000582680
    ENST00000579000 ENST00000394265(uc002hsc.3) ENST00000394267(uc002hsb.3)
    ENST00000580772 ENST00000583446 ENST00000492037 ENST00000580029

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R1B
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    Additional mRNA sequence: 

    AF233349.1 AF435972.1 AF435973.1 AF435974.1 AF464196.1 AK024593.1 AK123112.1 AK123950.1 
    AK124417.1 AK127542.1 AK129537.1 AK225058.1 AY070271.1 BC001519.2 BC118070.1 BC122554.1 
    BT007076.1 BX648641.1 

    12 DOTS entries:

    DT.415849  DT.97864082  DT.101984124  DT.91684332  DT.100795528  DT.101984126  DT.91759174  DT.70100705 
    DT.95087649  DT.100795525  DT.95291236  DT.120893113 

    24/984 AceView cDNA sequences (see all 984):

    AW661888 AI924991 BE328013 AI688891 BM713671 CA455295 AK127542 AA767480 
    CA390656 AI335884 CA398051 AI679490 BM795312 AI865332 CB141589 AI912491 
    NM_032192 AW882123 AA485238 AA122353 CA389360 BM046300 BU541964 BX506001 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:        -     -                 -                                                         
    SP2:                                -                                                         
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                -           -     -                                       


    ECgene alternative splicing isoforms for PPP1R1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R1B expression in normal human tissues (normalized intensities)      PPP1R1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPP1R1B Expression
    About this image


    PPP1R1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             Forebrain GABA neurons ( Generation of forebrain and spinal gamma-aminobutyric acid...
             Brain Pericytes   
             Olfactory Bulb   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced SM30 cells
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Spinal GABA neurons ( Generation of forebrain and spinal gamma-aminobutyric acid...
             Dorsal Horn   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See PPP1R1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R1B

    SOURCE GeneReport for Unigene cluster: Hs.286192
        SABiosciences Custom PCR Arrays for PPP1R1B
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R1B gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r1b1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 87.33(n)1
    88.54(a)1
      11 (61.75 cM)5
    190491  NM_144828.11  NP_659077.11 
     983484045 
    chicken
    (Gallus gallus)
    Aves PPP1R1B1 protein phosphatase 1, regulatory (inhibitor) subunit more 62.01(n)
    56.45(a)
      426639  XM_424268.3  XP_424268.3 
    zebrafish
    (Danio rerio)
    Actinopterygii PPP1R1B6
    protein phosphatase 1, regulatory (inhibitor) subu...
    31(a)
    1 ↔ 1
    19(5537231-5582870)


    ENSEMBL Gene Tree for PPP1R1B (if available)
    TreeFam Gene Tree for PPP1R1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R1B gene
    3 SIMAP similar genes for PPP1R1B using alignment to 4 protein entries:     PPR1B_HUMAN (see all proteins):
    LOC151242    PPP1R1A    PPP1R1C

    PPP1R1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 SNPs in PPP1R1B are shown (see all 260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407837381,2
    C--38568475(+) GGATCC/TGGGGA 1 -- us2k10--------
    rs1446553581,2
    --38568477(+) ATCCGA/GGGAAT 1 -- us2k10--------
    rs1926280631,2
    --38568658(+) ACCCTC/GCCAGC 1 -- us2k10--------
    rs1385531921,2
    --38568675(+) CTGTCC/TCCTTC 1 -- us2k10--------
    rs98996531,2
    C,F,A--38568704(+) CACACT/CGCCAG 1 -- us2k18Minor allele frequency- C:0.23NA WA CSA 249
    rs98928531,2
    C,F--38568707(+) ACTGCC/TAGCAC 1 -- us2k13Minor allele frequency- T:0.11NA WA 240
    rs1835840551,2
    C--38568732(+) CCCTTC/GCCCAC 1 -- us2k10--------
    rs47953901,2
    C,F,A,H--38568829(+) CCTCCC/GAAGGC 1 -- us2k112Minor allele frequency- G:0.29NA WA CSA EA 377
    rs355748381,2
    C--38568934(+) TGGGC-/CAACAACT 1 -- us2k10--------
    rs713536001,2
    C--38568935(+) GGGCC-/AACAACTT 1 -- us2k11Minor allele frequency- AAC:0.50NA 2

    HapMap Linkage Disequilibrium report for PPP1R1B (37782993 - 37792879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PPP1R1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2047CNV Insertion18451855
    nsv908207CNV Loss21882294
    dgv3163n71CNV Loss21882294
    nsv457738CNV Loss19166990
    nsv908212CNV Loss21882294
    dgv3162n71CNV Loss21882294
    nsv521294CNV Loss19592680
    dgv40n68CNV Loss17160897
    nsv516757CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604399    OMIM disorders: --

    18 diseases for PPP1R1B:    About MalaCards
    nicotine dependence    gastric adenocarcinoma    multiple system atrophy    autism spectrum disorder
    attention deficit hyperactivity disorder    neuronitis    anorexia nervosa    schizophrenia
    bipolar disorder    huntington's disease    choroiditis    parkinson's disease
    adenocarcinoma    ischemia    alcoholism    gastric cancer
    squamous cell carcinoma    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for PPP1R1B:
    Huntington's disease     Schizophrenia     Parkinson's disease

    PPP1R1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for PPP1R1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 82.4 1 16199832 (1)
    schizophrenia 49.3 25 16750903 (5), 18573638 (3), 17618027 (3), 19059449 (1) (see all 7)
    adenocarcinoma 0 7 15707466 (5), 16061638 (1), 14508844 (1)
    tumors 0 3 16061638 (1), 14508844 (1), 19301121 (1)

    Genetic Association Database (GAD): PPP1R1B
    Human Genome Epidemiology (HuGE) Navigator: PPP1R1B (24 documents)

    Export disorders for PPP1R1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R1B gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with PPP1R1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PubMed id 8120638)1, 2, 3, 9 Brene S.... Persson H. (1994)
    2. Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PubMed id 16750903)1, 4, 9 Li C.H....Chen C.H. (2006)
    3. Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PubMed id 17171661)1, 4, 9 Beuten J....Li M.D. (2007)
    4. An association study between PPP1R1B gene and schizophrenia in the Chinese population. (PubMed id 17618027)1, 4, 9 Hu J.X....He L. (2007)
    5. The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. (PubMed id 19463699)1, 4, 9 Reuter M....Montag C. (2009)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up . (PubMed id 21041608)1, 4 van Winkel R. (2010)
    9. Testing the antagonistic pleiotropy model of schizoph renia susceptibility by analysis of DAOA, PPP1R1B, and APOL1 genes. (PubMed id 20483474)1, 4 Carrera N....Costas J. (2010)
    10. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84152 HGNC: 9287 AceView: LASP1andPPP1R1B Ensembl:ENSG00000131771 euGenes: HUgn84152
    ECgene: PPP1R1B Kegg: 84152 H-InvDB: PPP1R1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1R1B gene:
    Search GeneIP for patents involving PPP1R1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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