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Aliases for PPP1R1B Gene

Aliases for PPP1R1B Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B 2 3 5
  • DARPP-32 3 4
  • DARPP32 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B 2
  • Dopamine And CAMP-Regulated Neuronal Phosphoprotein 32 3
  • Dopamine- And CAMP-Regulated Neuronal Phosphoprotein 4
  • Dopamine And CAMP Regulated Phosphoprotein 2

External Ids for PPP1R1B Gene

Previous GeneCards Identifiers for PPP1R1B Gene

  • GC17P037283
  • GC17P039780
  • GC17P037693
  • GC17P038158
  • GC17P035036
  • GC17P037783
  • GC17P033576

Summaries for PPP1R1B Gene

Entrez Gene Summary for PPP1R1B Gene

  • This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R1B Gene

PPP1R1B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B) is a Protein Coding gene. Diseases associated with PPP1R1B include Schizophrenia and Attention Deficit-Hyperactivity Disorder. Among its related pathways are cAMP signaling pathway and DAG and IP3 signaling. GO annotations related to this gene include protein phosphatase inhibitor activity and protein phosphatase type 1 regulator activity.

UniProtKB/Swiss-Prot for PPP1R1B Gene

  • Inhibitor of protein-phosphatase 1.

Gene Wiki entry for PPP1R1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R1B Gene

Genomics for PPP1R1B Gene

Regulatory Elements for PPP1R1B Gene

Enhancers for PPP1R1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R1B on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R1B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPP1R1B gene promoter:

Genomic Location for PPP1R1B Gene

Chromosome:
17
Start:
39,626,208 bp from pter
End:
39,636,626 bp from pter
Size:
10,419 bases
Orientation:
Plus strand

Genomic View for PPP1R1B Gene

Genes around PPP1R1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R1B Gene

Proteins for PPP1R1B Gene

  • Protein details for PPP1R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UD71-PPR1B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1B
    Protein Accession:
    Q9UD71
    Secondary Accessions:
    • Q547V9
    • Q547W0
    • Q9H7G1

    Protein attributes for PPP1R1B Gene

    Size:
    204 amino acids
    Molecular mass:
    22963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPP1R1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R1B Gene

Proteomics data for PPP1R1B Gene at MOPED

Post-translational modifications for PPP1R1B Gene

Other Protein References for PPP1R1B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP1R1B (DARPP-32)

No data available for DME Specific Peptides for PPP1R1B Gene

Domains & Families for PPP1R1B Gene

Gene Families for PPP1R1B Gene

Protein Domains for PPP1R1B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UD71

UniProtKB/Swiss-Prot:

PPR1B_HUMAN :
  • Belongs to the protein phosphatase inhibitor 1 family.
Family:
  • Belongs to the protein phosphatase inhibitor 1 family.
genes like me logo Genes that share domains with PPP1R1B: view

Function for PPP1R1B Gene

Molecular function for PPP1R1B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.

Gene Ontology (GO) - Molecular Function for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 10604473
GO:0004864 protein phosphatase inhibitor activity IEA,TAS 10604473
GO:0005515 protein binding IPI 25416956
GO:0008599 protein phosphatase type 1 regulator activity TAS --
GO:0031749 D2 dopamine receptor binding IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view
genes like me logo Genes that share phenotypes with PPP1R1B: view

Animal Models for PPP1R1B Gene

MGI Knock Outs for PPP1R1B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R1B Gene

Localization for PPP1R1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R1B Gene COMPARTMENTS Subcellular localization image for PPP1R1B gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PPP1R1B Gene

Pathways & Interactions for PPP1R1B Gene

genes like me logo Genes that share pathways with PPP1R1B: view

Gene Ontology (GO) - Biological Process for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA,TAS 10604473
GO:0007621 negative regulation of female receptivity IEA --
GO:0043086 negative regulation of catalytic activity TAS 10604473
GO:0071901 negative regulation of protein serine/threonine kinase activity TAS --
genes like me logo Genes that share ontologies with PPP1R1B: view

No data available for SIGNOR curated interactions for PPP1R1B Gene

Drugs & Compounds for PPP1R1B Gene

(14) Drugs for PPP1R1B Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ITI-007 Pharma 0

(2) Additional Compounds for PPP1R1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPP1R1B: view

Transcripts for PPP1R1B Gene

Unigene Clusters for PPP1R1B Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - - -
SP6: - -

Relevant External Links for PPP1R1B Gene

GeneLoc Exon Structure for
PPP1R1B
ECgene alternative splicing isoforms for
PPP1R1B

Expression for PPP1R1B Gene

mRNA expression in normal human tissues for PPP1R1B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R1B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x13.4), Brain - Caudate (basal ganglia) (x11.5), and Brain - Nucleus accumbens (basal ganglia) (x9.5).

Protein differential expression in normal tissues from HIPED for PPP1R1B Gene

This gene is overexpressed in Skin (24.0), Brain (15.5), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPP1R1B Gene



SOURCE GeneReport for Unigene cluster for PPP1R1B Gene Hs.286192

genes like me logo Genes that share expression patterns with PPP1R1B: view

Protein tissue co-expression partners for PPP1R1B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PPP1R1B Gene

Orthologs for PPP1R1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R1B 35
  • 90.26 (n)
  • 92.08 (a)
PPP1R1B 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R1B 35
  • 89.38 (n)
  • 90.2 (a)
PPP1R1B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r1b 35
  • 86.63 (n)
  • 86.98 (a)
Ppp1r1b 16
Ppp1r1b 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R1B 35
  • 98.03 (n)
  • 98.03 (a)
PPP1R1B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r1b 35
  • 86.6 (n)
  • 84.8 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R1B 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1R1B 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppp1r1b 36
  • 34 (a)
OneToOne
Species with no ortholog for PPP1R1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R1B Gene

ENSEMBL:
Gene Tree for PPP1R1B (if available)
TreeFam:
Gene Tree for PPP1R1B (if available)

Paralogs for PPP1R1B Gene

(3) SIMAP similar genes for PPP1R1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP1R1B: view

No data available for Paralogs for PPP1R1B Gene

Variants for PPP1R1B Gene

Sequence variations from dbSNP and Humsavar for PPP1R1B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193359 -- 39,626,678(+) TCCCC(A/G)CTGCC upstream-variant-2KB, utr-variant-5-prime
rs451849 -- 39,629,890(+) TGGGT(C/G)GGCAT intron-variant
rs380503 -- 39,629,892(+) GGTCG(C/G)CATGG intron-variant
rs392741 -- 39,632,555(-) CTCTA(A/G)GGCCC intron-variant
rs879606 -- 39,625,596(+) TCTGG(A/G)CCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R1B Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV Loss 17160897
nsv521294 CNV Loss 19592680
dgv3162n71 CNV Loss 21882294
nsv908207 CNV Loss 21882294
dgv3163n71 CNV Loss 21882294
nsv2047 CNV Insertion 18451855
nsv908212 CNV Loss 21882294
nsv457738 CNV Loss 19166990
nsv516757 CNV Loss 19592680

Variation tolerance for PPP1R1B Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R1B Gene

Disorders for PPP1R1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPP1R1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP1R1B

Genetic Association Database (GAD)
PPP1R1B
Human Genome Epidemiology (HuGE) Navigator
PPP1R1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R1B
genes like me logo Genes that share disorders with PPP1R1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R1B Gene

Publications for PPP1R1B Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brene S. … Persson H. (J. Neurosci. 1994) 2 3 4 23 67
  2. Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers. (PMID: 19301121) Hamel S. … Basik M. (Breast Cancer Res. Treat. 2010) 3 23
  3. The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder. (PMID: 19059449) Torres K.C. … Romano-Silva M.A. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2009) 3 23
  4. The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. (PMID: 19463699) Reuter M. … Montag C. (Behav. Brain Res. 2009) 3 23
  5. Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. (PMID: 19651774) Hansen C. … Andersson T. (J. Biol. Chem. 2009) 3 23

Products for PPP1R1B Gene

Sources for PPP1R1B Gene

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