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Aliases for PPP1R1B Gene

Aliases for PPP1R1B Gene

  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B 2 3
  • DARPP-32 3 4
  • DARPP32 3 4
  • Dopamine And CAMP-Regulated Neuronal Phosphoprotein 32 3
  • Dopamine- And CAMP-Regulated Neuronal Phosphoprotein 4
  • Protein Phosphatase 1 Regulatory Subunit 1B 3
  • Dopamine And CAMP Regulated Phosphoprotein 2

External Ids for PPP1R1B Gene

Previous GeneCards Identifiers for PPP1R1B Gene

  • GC17P037283
  • GC17P039780
  • GC17P037693
  • GC17P038158
  • GC17P035036
  • GC17P037783
  • GC17P033576

Summaries for PPP1R1B Gene

Entrez Gene Summary for PPP1R1B Gene

  • This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R1B Gene

PPP1R1B (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B) is a Protein Coding gene. Diseases associated with PPP1R1B include schizophrenia. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include receptor binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R1B Gene

  • Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R1B Gene

Genomics for PPP1R1B Gene

Regulatory Elements for PPP1R1B Gene

Transcription factor binding sites by QIAGEN in the PPP1R1B gene promoter:

Genomic Location for PPP1R1B Gene

Start:
39,626,740 bp from pter
End:
39,636,626 bp from pter
Size:
9,887 bases
Orientation:
Plus strand

Genomic View for PPP1R1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R1B Gene

Proteins for PPP1R1B Gene

  • Protein details for PPP1R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UD71-PPR1B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1B
    Protein Accession:
    Q9UD71
    Secondary Accessions:
    • Q547V9
    • Q547W0
    • Q9H7G1

    Protein attributes for PPP1R1B Gene

    Size:
    204 amino acids
    Molecular mass:
    22963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPP1R1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R1B Gene

Proteomics data for PPP1R1B Gene at MOPED

Post-translational modifications for PPP1R1B Gene

Other Protein References for PPP1R1B Gene

No data available for DME Specific Peptides for PPP1R1B Gene

Domains for PPP1R1B Gene

Gene Families for PPP1R1B Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R1B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UD71

UniProtKB/Swiss-Prot:

PPR1B_HUMAN :
  • Q9UD71
Family:
  • Belongs to the protein phosphatase inhibitor 1 family.
genes like me logo Genes that share domains with PPP1R1B: view

Function for PPP1R1B Gene

Molecular function for PPP1R1B Gene

UniProtKB/Swiss-Prot Function: Inhibitor of protein-phosphatase 1

Gene Ontology (GO) - Molecular Function for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 10604473
GO:0004864 protein phosphatase inhibitor activity TAS 10604473
GO:0004865 protein serine/threonine phosphatase inhibitor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008599 protein phosphatase type 1 regulator activity TAS --
genes like me logo Genes that share ontologies with PPP1R1B: view
genes like me logo Genes that share phenotypes with PPP1R1B: view

Animal Models for PPP1R1B Gene

MGI Knock Outs for PPP1R1B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PPP1R1B Gene

Localization for PPP1R1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R1B Gene COMPARTMENTS Subcellular localization image for PPP1R1B gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view

Pathways for PPP1R1B Gene

genes like me logo Genes that share pathways with PPP1R1B: view

Pathways by source for PPP1R1B Gene

Gene Ontology (GO) - Biological Process for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006469 negative regulation of protein kinase activity TAS 10604473
GO:0007165 signal transduction TAS 10604473
GO:0007621 negative regulation of female receptivity IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view

Compounds for PPP1R1B Gene

(3) HMDB Compounds for PPP1R1B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(15) Novoseek inferred chemical compound relationships for PPP1R1B Gene

Compound -log(P) Hits PubMed IDs
dopamine 78.3 69
okadaic acid 38.1 1
glutamate 34.4 10
threonine 32 3
cyclic amp 19.7 2
genes like me logo Genes that share compounds with PPP1R1B: view

Transcripts for PPP1R1B Gene

Unigene Clusters for PPP1R1B Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - - -
SP6: - -

Relevant External Links for PPP1R1B Gene

GeneLoc Exon Structure for
PPP1R1B
ECgene alternative splicing isoforms for
PPP1R1B

Expression for PPP1R1B Gene

mRNA expression in normal human tissues for PPP1R1B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R1B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (13.4), Brain - Caudate (basal ganglia) (11.5), and Brain - Nucleus accumbens (basal ganglia) (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPP1R1B Gene

SOURCE GeneReport for Unigene cluster for PPP1R1B Gene Hs.286192

genes like me logo Genes that share expressions with PPP1R1B: view

No data available for mRNA Expression by UniProt/SwissProt for PPP1R1B Gene

Orthologs for PPP1R1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R1B 35
  • 98.03 (n)
  • 98.03 (a)
PPP1R1B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R1B 35
  • 90.26 (n)
  • 92.08 (a)
PPP1R1B 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R1B 35
  • 89.38 (n)
  • 90.2 (a)
PPP1R1B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r1b 35
  • 86.63 (n)
  • 86.98 (a)
Ppp1r1b 16
Ppp1r1b 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R1B 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r1b 35
  • 86.6 (n)
  • 84.8 (a)
chicken
(Gallus gallus)
Aves PPP1R1B 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppp1r1b 36
  • 34 (a)
OneToOne
Species with no ortholog for PPP1R1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R1B Gene

ENSEMBL:
Gene Tree for PPP1R1B (if available)
TreeFam:
Gene Tree for PPP1R1B (if available)

Paralogs for PPP1R1B Gene

Selected SIMAP similar genes for PPP1R1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP1R1B: view

No data available for Paralogs for PPP1R1B Gene

Variants for PPP1R1B Gene

Sequence variations from dbSNP and Humsavar for PPP1R1B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs193359 -- 39,626,678(+) TCCCC(A/G)CTGCC upstream-variant-2KB
rs380503 -- 39,629,892(+) GGTCG(C/G)CATGG intron-variant
rs392741 -- 39,632,555(-) CTCTA(A/G)GGCCC intron-variant
rs451849 -- 39,629,890(+) TGGGT(C/G)GGCAT intron-variant
rs879606 -- 39,625,596(+) TCTGG(A/G)CCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R1B Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV Loss 17160897
nsv521294 CNV Loss 19592680
dgv3162n71 CNV Loss 21882294
nsv908207 CNV Loss 21882294
dgv3163n71 CNV Loss 21882294
nsv2047 CNV Insertion 18451855
nsv908212 CNV Loss 21882294
nsv457738 CNV Loss 19166990
nsv516757 CNV Loss 19592680

Relevant External Links for PPP1R1B Gene

HapMap Linkage Disequilibrium report
PPP1R1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R1B Gene

Disorders for PPP1R1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PPP1R1B Gene including...

Search for PPP1R1B Gene in MalaCards »

(3) University of Copenhagen DISEASES for PPP1R1B Gene

(4) Novoseek inferred disease relationships for PPP1R1B Gene

Disease -log(P) Hits PubMed IDs
calcyon 82.4 1
schizophrenia 49.3 15
adenocarcinoma 0 7
tumors 0 3

Relevant External Links for PPP1R1B

Genetic Association Database (GAD)
PPP1R1B
Human Genome Epidemiology (HuGE) Navigator
PPP1R1B
genes like me logo Genes that share disorders with PPP1R1B: view

No data available for UniProtKB/Swiss-Prot for PPP1R1B Gene

Publications for PPP1R1B Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brene S. … Persson H. (J. Neurosci. 1994) 2 3 4 23
  2. Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PMID: 16750903) Li C.H. … Chen C.H. (Schizophr. Res. 2006) 3 23 48
  3. Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PMID: 17171661) Beuten J. … Li M.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  4. An association study between PPP1R1B gene and schizophrenia in the Chinese population. (PMID: 17618027) Hu J.X. … He L. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2007) 3 23 48
  5. The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. (PMID: 19463699) Reuter M. … Montag C. (Behav. Brain Res. 2009) 3 23 48

Products for PPP1R1B Gene

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Sources for PPP1R1B Gene

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