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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPP1R1B Gene

protein-coding GIFtS: 64
GCID: GC17P037783

protein phosphatase 1, regulatory (inhibitor) subunit 1B

Explore 19 diseases affiliated with
PPP1R1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B¹ ²		Dopamine And CAMP-Regulated Neuronal Phosphoprotein 32²
DARPP-32¹ ² ³		Protein Phosphatase 1 Regulatory Subunit 1B²
DARPP32² ³		Dopamine- And CAMP-Regulated Neuronal Phosphoprotein³
FLJ20940¹

External Ids:	HGNC: 9287¹	Entrez Gene: 84152²	Ensembl: ENSG00000131771⁷	OMIM: 604399⁵	UniProtKB: Q9UD71³

Export aliases for PPP1R1B gene to outside databases

Previous GC identifers: GC17P037283 GC17P039780 GC17P037693 GC17P038158 GC17P035036 GC17P033576

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R1B:

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation

regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene

may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71

Function: Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPP1R1B gene promoter:
CREB Sp1 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1R1B promoter sequence

Search SABiosciences Chromatin IP Primers for PPP1R1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12

PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R1B gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P037783: view genomic region (about GC identifiers)

Start:	37,782,993 bp from pter	End:	37,792,879 bp from pter
Size:	9,887 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71 (See protein sequence)

Recommended Name: Protein phosphatase 1 regulatory subunit 1B

Size: 204 amino acids; 22963 Da

Subcellular location: Cytoplasm

Secondary accessions: Q547V9 Q547W0 Q9H7G1

Alternative splicing: 2 isoforms: Q9UD71-1 Q9UD71-2

Explore the universe of human proteins at neXtProt for PPP1R1B: NX_Q9UD71

Post-translational modifications:

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein¹

Phosphorylation of Thr-34 is required for activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UD71

PPP1R1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001229393.1 NP_115568.2 NP_852606.1

ENSEMBL proteins:

ENSP00000462137 ENSP00000254079 ENSP00000462522 ENSP00000377813 ENSP00000462841

ENSP00000463028 ENSP00000377808 ENSP00000377810 ENSP00000349688

Reactome Protein details: Q9UD71
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PPP1R1B

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	NAS	--
GO:0005829	cytosol	TAS	--
GO:0043025	neuronal cell body	IEA	--

PPP1R1B for ontologies About GeneDecksing

PPP1R1B Antibody Products:

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	Uscn ELISAs and CLIAs for PPP1R1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPP1R1B for domains About GeneDecksing

2 InterPro domains/families:

IPR015670 Dopamine/cAMP_neuron_P-prot

IPR008466 PPI_1DARPP-32

Graphical View of Domain Structure for InterPro Entry Q9UD71

ProtoNet protein and cluster: Q9UD71

1 Blocks protein family: IPB008466 Protein phosphatase inhibitor

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71

Similarity: Belongs to the protein phosphatase inhibitor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71

Function: Inhibitor of protein-phosphatase 1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PPP1R1B Browse MicroRNA Expression Plasmids
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		hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-3175 hsa-miR-3157-5p hsa-miR-221* hsa-miR-2355-5p hsa-miR-524-5p

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R1B

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004860	protein kinase inhibitor activity	TAS	10604473
GO:0004864	protein phosphatase inhibitor activity	TAS	10604473
GO:0005102	receptor binding	IEA	--
GO:0008599	protein phosphatase type 1 regulator activity	TAS	--

PPP1R1B for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for PPP1R1B:

Decreased focal adhesion (FA)

Decreased telomerase activity

Stronger migration

Animal Models:
Mouse knock-out Ppp1r1b^tm1Aaf for PPP1R1B
3 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ppp1r1b):

behavior/neurological

homeostasis/metabolism

nervous system

PPP1R1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Erythropoietin Pathway

	Erythropoietin Pathway	1.00			Insulin Receptor Pathway	0.37
	Beta-Adrenergic Signaling	0.37			CDK5 Pathway	0.21

Opioid Signalling

Opioid Signalling

1.00

DARPP-32 events

0.30

Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

1.00

Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling

0.98

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1.00

Nicotine Activity on Dopaminergic Neurons

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PPP1R1B

	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Signal transduction PKA signaling

5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R1B (see all 14)

	Activation of PKA through GPCR
	PKA Signaling
	eIF2 Pathway
	CDK5 Pathway
	Breast Cancer Regulation by Stathmin1

2 Cell Signaling Technology (CST) Pathways for PPP1R1B

	Ca, cAMP and Lipid Signaling
	Neuroscience

1 Tocris Bioscience Pathway for PPP1R1B

Insulin Pathway

2 GeneGo (Thomson Reuters) Pathways for PPP1R1B

	Signal transduction PKA signaling
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

1 BioSystems Pathway for PPP1R1B

Nicotine Activity on Dopaminergic Neurons

4 Reactome Pathways for PPP1R1B

	DARPP-32 events
	Signal Transduction
	Signaling by GPCR
	Opioid Signalling

1 PharmGKB Pathway for PPP1R1B

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

PPP1R1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPP1R1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/17 Interacting proteins for PPP1R1B (Q9UD71^{2, 3} ENSP00000254079⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ROBO2	Q9HCK4²^,³	MINT-65696 I2D: score=3
CDK5	Q00535³, ENSP00000297518⁴	I2D: score=1 STRING: ENSP00000297518
CSNK2A2	P19784³, ENSP00000262506⁴	I2D: score=1 STRING: ENSP00000262506
PPP1CA	P62136³, ENSP00000326031⁴	I2D: score=1 STRING: ENSP00000326031
PRKACA	P17612³, ENSP00000309591⁴	I2D: score=1 STRING: ENSP00000309591

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001975	response to amphetamine	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006469	negative regulation of protein kinase activity	TAS	10604473
GO:0007165	signal transduction	TAS	10604473
GO:0007621	negative regulation of female receptivity	IEA	--

PPP1R1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPP1R1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPP1R1B

3 HMDB Compounds for PPP1R1B About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/15 Novoseek chemical compound relationships for PPP1R1B gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dopamine	78.3	91	1663529 (3), 17194217 (3), 16965177 (3), 17948899 (2) (see all 55)
okadaic acid	38.1	1	9606178 (1)
glutamate	34.4	12	17194217 (3), 12538871 (2), 9483560 (2), 8248241 (1) (see all 6)
threonine	32	3	15464122 (1), 9108011 (1), 16353915 (1)
cyclic amp	19.7	2	1975775 (1), 8298087 (1)
tyrosine	17.2	9	1971224 (2), 9483560 (2), 1975775 (1), 19254752 (1) (see all 6)
serine	16.8	3	15464122 (1), 14744247 (1), 16353915 (1)
nicotine	16.1	9	16040813 (4), 17171661 (2)
forskolin	9.36	3	9606178 (2), 12538871 (1)
nmda	6.68	1	16764827 (1)

Search CenterWatch for drugs/clinical trials and news about PPP1R1B / PPR1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPP1R1B gene (3 alternative transcripts):

NM_001242464.1 NM_032192.3 NM_181505.3

Unigene Cluster for PPP1R1B:

Protein phosphatase 1, regulatory (inhibitor) subunit 1B

Hs.286192 [show with all ESTs]

Unigene Representative Sequence: AK123950

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000580825 ENST00000254079(uc002hrz.3 uc010cvx.3) ENST00000582680

ENST00000394271 ENST00000579000 ENST00000466381 ENST00000394265(uc002hsc.3)

ENST00000394267(uc002hsb.3) ENST00000580772 ENST00000583446 ENST00000492037

ENST00000580029 ENST00000357165

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		hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-3175 hsa-miR-3157-5p hsa-miR-221* hsa-miR-2355-5p hsa-miR-524-5p

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R1B

Additional cDNA sequence:

AF233349.1 AF435972.1 AF435973.1 AF435974.1 AF464196.1 AK024593.1 AK123112.1 AK123950.1

AK124417.1 AK127542.1 AK129537.1 AK225058.1 AY070271.1 BC001519.2 BC118070.1 BC122554.1

BT007076.1 BX648641.1

12 DOTS entries:

DT.415849 DT.97864082 DT.101984124 DT.91684332 DT.100795528 DT.101984126 DT.91759174 DT.70100705

DT.95087649 DT.100795525 DT.95291236 DT.120893113

24/984 AceView cDNA sequences (see all 984):

AA662372 BF916837 AL532968 AW069179 AI287574 AF435973 AK129537 AW860349

BM856382 BM746502 BQ961916 CA390656 BP362580 BI087435 AA580888 AK127542

CK819273 AA595258 AK123112 BM996225 BM851743 BG122305 AW769172 BM824053

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10
SP1:			-		-						-
SP2:											-
SP3:
SP4:
SP5:											-				-		-

ECgene alternative splicing isoforms for PPP1R1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP1R1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

PPP1R1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Forebrain GABA neurons (Generation of forebr...)

Brain

Spinal GABA neurons (Generation of forebr...)

Spinal Cord

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PPP1R1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP1R1B

SOURCE GeneReport for Unigene cluster: Hs.286192

SABiosciences Custom PCR Arrays for PPP1R1B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1B gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPP1R1B¹	protein phosphatase 1, regulatory (inhibitor) subunit more	62.01(n) 56.45(a)		426639 XM_424268.3 XP_424268.3
zebrafish (Danio rerio)	Actinopterygii	CU682353.1⁶	--	38(a)	1 ↔ 1	19(5537231-5582870)

ENSEMBL Gene Tree for PPP1R1B (if available)
TreeFam Gene Tree for PPP1R1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPP1R1B gene

PPP1R1A² PPP1R1C²

3 SIMAP similar genes for PPP1R1B using alignment to 6 protein entries: PPR1B_HUMAN (see all proteins):

LOC151242 PPP1R1A PPP1R1C

PPP1R1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9892853^1,2	C,	--	33575215(+)	`ACTGCC/TAGCAC`	1	--	us2k¹		3		NA WA	240
rs11651233^1,2	C,H,	--	33575781(+)	`TACACA/GTCTAC`	1	--	us2k¹		0	--	--	--	--
rs72827170^1,2		--	33575919(+)	`CACAGA/GGCCAG`	1	--	us2k¹		0	--	--	--	--
rs34445181^1,2	C,F,	--	33576949(+)	`GCGGAG/AAGGAG`	3	--	ut5¹ us2k¹		3		NA WA	122
rs79160742^1,2		--	33576988(+)	`GACGGA/GAGAGG`	3	--	ut5¹ us2k¹		0	--	--	--	--
rs77771105^1,2	C,	--	33577258(+)	`ACAGCC/TCTCCT`	3	--	ut5¹ us2k¹		1		WA	118
rs11869360^1,2	C,H	--	33577888(+)	`AGTATG/AAGGCT`	3	--	int¹ us2k¹		3		NS NA	184
rs35591311^1,2	C,F,	--	33578200(+)	`CCACTG/AAGCAG`	3	--	int¹ us2k¹		1		NA	120
rs73308310^1,2	C,	--	33578638(+)	`CTTCTG/AAAAAG`	3	--	ut5¹ int¹		2		WA	120
rs59894839^1,2		--	33578889(+)	`GGAGTA/CAGTGA`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPP1R1B (37782993 - 37792879 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PPP1R1B
2 CNVs: 77591 49853

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing PPP1R1B:

Gastric Cancer

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PPP1R1B for disorders           About GeneDecksing

OMIM gene information: 604399    OMIM disorders: --

19 diseases for PPP1R1B:    About MalaCards

attention deficit hyperactivity disorder autism spectrum disorder nicotine dependence multiple system atrophy

anorexia nervosa neuronitis squamous cell carcinoma bipolar disorder

huntington's disease gastric adenocarcinoma parkinson's disease schizophrenia

adenocarcinoma choroiditis gastric cancer breast cancer

ischemia carcinoma alcoholism

3 diseases from the University of Copenhagen DISEASES database for PPP1R1B:

Huntington's disease Schizophrenia Parkinson's disease

4 Novoseek disease relationships for PPP1R1B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcyon	82.4	1	16199832 (1)
schizophrenia	49.3	25	16750903 (5), 18573638 (3), 17618027 (3), 19059449 (1) (see all 7)
adenocarcinoma	0	7	15707466 (5), 16061638 (1), 14508844 (1)
tumors	0	3	16061638 (1), 14508844 (1), 19301121 (1)

Human Genome Epidemiology (HuGE) Navigator: PPP1R1B (24 documents)

Export disorders for PPP1R1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPP1R1B gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with PPP1R1B)

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Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PubMed id 8120638)^{1, 2, 3, 9} Brene S.... Persson H. (1994)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. (PubMed id 12124342)^{1, 2} El-Rifai W....Powell S.M. (2002)
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. (PubMed id 10604473)^{1, 2} Bibb J.A.... Greengard P. (1999)
Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PubMed id 16750903)^{1, 9} Li C.H....Chen C.H. (2006)
Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. (PubMed id 14508844)^{1, 9} Beckler A....El-Rifai W. (2003)
Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32. (PubMed id 17492506)^{1, 9} Hong L....Fan D. (2008)
Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PubMed id 17171661)^{1, 9} Beuten J....Li M.D. (2007)
Wnt-5a-induced phosphorylation of DARPP-32 inhibits b reast cancer cell migration in a CREB-dependent manner. (PubMed id 19651774)^{1, 9} Hansen C....Andersson T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84152	HGNC: 9287	AceView: LASP1andPPP1R1B	Ensembl:ENSG00000131771	euGenes: HUgn84152
ECgene: PPP1R1B	H-InvDB: PPP1R1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PPP1R1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPP1R1B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PPP1R1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PPP1R1B gene:
Search GeneIP for patents involving PPP1R1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PPP1R1B Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1B

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PPP1R1B Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1B

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