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Aliases for PPP1R1A Gene

Aliases for PPP1R1A Gene

  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1A 2 3
  • Protein Phosphatase Inhibitor 1 3 4
  • IPP-1 3 4
  • IPP1 3 4
  • I-1 3 4
  • Protein Phosphatase Inhibitor-1 3
  • Inhibitor-1 3
  • I1 3

External Ids for PPP1R1A Gene

Previous GeneCards Identifiers for PPP1R1A Gene

  • GC12M055099
  • GC12M054689
  • GC12M053259
  • GC12M053255
  • GC12M054971
  • GC12M052011

Summaries for PPP1R1A Gene

GeneCards Summary for PPP1R1A Gene

PPP1R1A (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1A) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. GO annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R1C.

UniProtKB/Swiss-Prot for PPP1R1A Gene

  • Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R1A Gene

Genomics for PPP1R1A Gene

Regulatory Elements for PPP1R1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1R1A Gene

Chromosome:
12
Start:
54,575,387 bp from pter
End:
54,588,677 bp from pter
Size:
13,291 bases
Orientation:
Minus strand

Genomic View for PPP1R1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R1A Gene

Proteins for PPP1R1A Gene

  • Protein details for PPP1R1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13522-PPR1A_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1A
    Protein Accession:
    Q13522
    Secondary Accessions:
    • Q6IB01
    • Q8TBJ2
    • Q8WWV2

    Protein attributes for PPP1R1A Gene

    Size:
    171 amino acids
    Molecular mass:
    19011 Da
    Quaternary structure:
    • Interacts with PPP1R15A.

neXtProt entry for PPP1R1A Gene

Proteomics data for PPP1R1A Gene at MOPED

Post-translational modifications for PPP1R1A Gene

Other Protein References for PPP1R1A Gene

Antibody Products

No data available for DME Specific Peptides for PPP1R1A Gene

Domains & Families for PPP1R1A Gene

Gene Families for PPP1R1A Gene

Protein Domains for PPP1R1A Gene

Suggested Antigen Peptide Sequences for PPP1R1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13522

UniProtKB/Swiss-Prot:

PPR1A_HUMAN :
  • Belongs to the protein phosphatase inhibitor 1 family.
Family:
  • Belongs to the protein phosphatase inhibitor 1 family.
genes like me logo Genes that share domains with PPP1R1A: view

Function for PPP1R1A Gene

Molecular function for PPP1R1A Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases

Gene Ontology (GO) - Molecular Function for PPP1R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity --
GO:0004865 protein serine/threonine phosphatase inhibitor activity TAS 8611507
GO:0005515 protein binding IPI 11564868
genes like me logo Genes that share ontologies with PPP1R1A: view
genes like me logo Genes that share phenotypes with PPP1R1A: view

Animal Models for PPP1R1A Gene

MGI Knock Outs for PPP1R1A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PPP1R1A Gene

Localization for PPP1R1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R1A Gene COMPARTMENTS Subcellular localization image for PPP1R1A gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2

Gene Ontology (GO) - Cellular Components for PPP1R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PPP1R1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R1A Gene

Pathways & Interactions for PPP1R1A Gene

genes like me logo Genes that share pathways with PPP1R1A: view

Gene Ontology (GO) - Biological Process for PPP1R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0007165 signal transduction --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with PPP1R1A: view

No data available for SIGNOR curated interactions for PPP1R1A Gene

Drugs & Compounds for PPP1R1A Gene

(2) Drugs for PPP1R1A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Calcium Nutra 0
genes like me logo Genes that share compounds with PPP1R1A: view

Transcripts for PPP1R1A Gene

Unigene Clusters for PPP1R1A Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -

Relevant External Links for PPP1R1A Gene

GeneLoc Exon Structure for
PPP1R1A
ECgene alternative splicing isoforms for
PPP1R1A

Expression for PPP1R1A Gene

mRNA expression in normal human tissues for PPP1R1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R1A Gene

This gene is overexpressed in Muscle - Skeletal (x12.0), Adipose - Subcutaneous (x4.5), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for PPP1R1A Gene

This gene is overexpressed in Heart (47.7), Fetal Brain (11.4), and Fetal heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPP1R1A Gene



SOURCE GeneReport for Unigene cluster for PPP1R1A Gene Hs.505662

genes like me logo Genes that share expression patterns with PPP1R1A: view

Protein tissue co-expression partners for PPP1R1A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PPP1R1A Gene

Orthologs for PPP1R1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ppp1r1a 35
  • 86.35 (n)
  • 79.53 (a)
Ppp1r1a 16
Ppp1r1a 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R1A 35
  • 98.2 (n)
  • 97.3 (a)
PPP1R1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r1a 35
  • 84.8 (n)
  • 80.7 (a)
cow
(Bos Taurus)
Mammalia PPP1R1A 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R1A 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R1A 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R1A 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15285 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398661 35
Species with no ortholog for PPP1R1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPP1R1A Gene

ENSEMBL:
Gene Tree for PPP1R1A (if available)
TreeFam:
Gene Tree for PPP1R1A (if available)

Paralogs for PPP1R1A Gene

Paralogs for PPP1R1A Gene

(3) SIMAP similar genes for PPP1R1A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PPP1R1A Gene

genes like me logo Genes that share paralogs with PPP1R1A: view

Variants for PPP1R1A Gene

Sequence variations from dbSNP and Humsavar for PPP1R1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8407 -- 54,581,019(-) CACGA(A/G)AGAGG synonymous-codon, reference, missense
rs1143960 -- 54,580,687(+) ATCCA(C/T)GGCCT intron-variant, downstream-variant-500B
rs1144997 -- 54,585,042(-) TTAAC(A/G)TCTTG intron-variant
rs1144998 -- 54,585,609(-) CTCCT(C/G)TCAGC intron-variant
rs1144999 -- 54,585,722(-) GGGCA(C/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R1A Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV Gain 17160897

Variation tolerance for PPP1R1A Gene

Residual Variation Intolerance Score: 50.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R1A Gene

HapMap Linkage Disequilibrium report
PPP1R1A
Human Gene Mutation Database (HGMD)
PPP1R1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R1A Gene

Disorders for PPP1R1A Gene

Relevant External Links for PPP1R1A

Genetic Association Database (GAD)
PPP1R1A
Human Genome Epidemiology (HuGE) Navigator
PPP1R1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R1A
genes like me logo Genes that share disorders with PPP1R1A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R1A Gene

Publications for PPP1R1A Gene

  1. Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. (PMID: 8611507) Endo S. … Shenolikar S. (Biochemistry 1996) 2 23 67
  2. Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. (PMID: 20071777) WittkAPpper K. … El-Armouche A. (J. Clin. Invest. 2010) 23 67
  3. Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. (PMID: 17200417) Han J. … Zheng J.Q. (J. Cell Biol. 2007) 23 67
  4. Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts. (PMID: 14732205) El-Armouche A. … Eschenhagen T. (Cardiovasc. Res. 2004) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for PPP1R1A Gene

Sources for PPP1R1A Gene

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