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Aliases for PPP1R16B Gene

Aliases for PPP1R16B Gene

  • Protein Phosphatase 1, Regulatory Subunit 16B 2 3
  • TGF-Beta-Inhibited Membrane-Associated Protein 2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16B 2 3
  • Ankyrin Repeat Domain-Containing Protein 4 3 4
  • Ankyrin Repeat Domain Protein 4 2 3
  • CAAX Box Protein TIMAP 3 4
  • KIAA0823 4 6
  • ANKRD4 3 4
  • HTIMAP 3 4
  • TIMAP 3 6
  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 16B 3

External Ids for PPP1R16B Gene

Summaries for PPP1R16B Gene

Entrez Gene Summary for PPP1R16B Gene

  • The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

GeneCards Summary for PPP1R16B Gene

PPP1R16B (Protein Phosphatase 1, Regulatory Subunit 16B) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase binding. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R16B Gene

  • Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R16B Gene

Genomics for PPP1R16B Gene

Genomic Location for PPP1R16B Gene

Start:
38,805,705 bp from pter
End:
38,923,024 bp from pter
Size:
117,320 bases
Orientation:
Plus strand

Genomic View for PPP1R16B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R16B Gene

Regulatory Elements for PPP1R16B Gene

Proteins for PPP1R16B Gene

  • Protein details for PPP1R16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T49-PP16B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory inhibitor subunit 16B
    Protein Accession:
    Q96T49
    Secondary Accessions:
    • A2RRR6
    • E9PFS8
    • O94912
    • Q5W9G4
    • Q9NQG4

    Protein attributes for PPP1R16B Gene

    Size:
    567 amino acids
    Molecular mass:
    63551 Da
    Quaternary structure:
    • Interacts with PPP1CA, PPP1CB and MSN. Interacts (via its fourth ankyrin repeat) with the mature dimeric form of RPSA/LAMR1.
    SequenceCaution:
    • Sequence=BAA74846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R16B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R16B Gene

Proteomics data for PPP1R16B Gene at MOPED

Post-translational modifications for PPP1R16B Gene

  • Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R16B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R16B Gene

Domains for PPP1R16B Gene

Gene Families for PPP1R16B Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R16B Gene

UniProtKB/Swiss-Prot:

PP16B_HUMAN
Similarity:
  • Contains 5 ANK repeats.:
    • Q96T49
genes like me logo Genes that share domains with PPP1R16B: view

Function for PPP1R16B Gene

Molecular function for PPP1R16B Gene

UniProtKB/Swiss-Prot Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
UniProtKB/Swiss-Prot Induction: Inhibited by TGFB1

Gene Ontology (GO) - Molecular Function for PPP1R16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16263087
GO:0008599 protein phosphatase type 1 regulator activity IDA 16263087
GO:0019903 protein phosphatase binding --
genes like me logo Genes that share ontologies with PPP1R16B: view
genes like me logo Genes that share phenotypes with PPP1R16B: view

Animal Models for PPP1R16B Gene

MGI Knock Outs for PPP1R16B:

miRNA for PPP1R16B Gene

miRTarBase miRNAs that target PPP1R16B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP1R16B Gene

Localization for PPP1R16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16B Gene

Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Note=Colocalizes with RPSA/LAMR1 in the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R16B Gene COMPARTMENTS Subcellular localization image for PPP1R16B gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PPP1R16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12055102
GO:0005886 plasma membrane IDA 12055102
GO:0042995 cell projection IDA 25007873
GO:0048471 perinuclear region of cytoplasm IDA 12055102
genes like me logo Genes that share ontologies with PPP1R16B: view

Pathways for PPP1R16B Gene

SuperPathways for PPP1R16B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 25007873
GO:0007165 signal transduction --
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling IMP 25007873
GO:0035307 positive regulation of protein dephosphorylation IDA 16263087
GO:0035308 negative regulation of protein dephosphorylation IDA 21466834
genes like me logo Genes that share ontologies with PPP1R16B: view

No data available for Pathways by source for PPP1R16B Gene

Transcripts for PPP1R16B Gene

mRNA/cDNA for PPP1R16B Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R16B Gene

Protein phosphatase 1, regulatory subunit 16B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: -
SP3: -
SP4: -

Relevant External Links for PPP1R16B Gene

GeneLoc Exon Structure for
PPP1R16B
ECgene alternative splicing isoforms for
PPP1R16B

Expression for PPP1R16B Gene

mRNA expression in normal human tissues for PPP1R16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R16B Gene

This gene is overexpressed in Brain - Cortex (4.8), Brain - Nucleus accumbens (basal ganglia) (4.8), Brain - Putamen (basal ganglia) (4.6), and Brain - Caudate (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPP1R16B Gene

SOURCE GeneReport for Unigene cluster for PPP1R16B Gene Hs.45719

mRNA Expression by UniProt/SwissProt for PPP1R16B Gene

Q96T49-PP16B_HUMAN
Tissue specificity: Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis
genes like me logo Genes that share expressions with PPP1R16B: view

Orthologs for PPP1R16B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R16B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R16B 36
  • 98.69 (n)
  • 98.68 (a)
PPP1R16B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R16B 36
  • 91.18 (n)
  • 97 (a)
PPP1R16B 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R16B 36
  • 92.53 (n)
  • 97.35 (a)
PPP1R16B 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r16b 36
  • 90.06 (n)
  • 96.47 (a)
Ppp1r16b 16
Ppp1r16b 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R16B 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R16B 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r16b 36
  • 89.71 (n)
  • 95.94 (a)
chicken
(Gallus gallus)
Aves PPP1R16B 36
  • 76.21 (n)
  • 78.09 (a)
PPP1R16B 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R16B 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r16b 36
  • 64.21 (n)
  • 59.92 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799771 36
  • 64.23 (n)
  • 63.5 (a)
PPP1R16B 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MYPT-75D 37
  • 28 (a)
OneToMany
CG6896 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea gfi-2 37
  • 37 (a)
OneToMany
gfi-2 38
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1404 37
  • 51 (a)
OneToMany
Species with no ortholog for PPP1R16B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R16B Gene

ENSEMBL:
Gene Tree for PPP1R16B (if available)
TreeFam:
Gene Tree for PPP1R16B (if available)

Paralogs for PPP1R16B Gene

Paralogs for PPP1R16B Gene

Selected SIMAP similar genes for PPP1R16B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP1R16B: view

Variants for PPP1R16B Gene

Sequence variations from dbSNP and Humsavar for PPP1R16B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs10392 -- 38,922,292(+) ATTGT(A/G)GTTGT utr-variant-3-prime
rs10477 -- 38,922,825(-) AGATC(C/T)GCGAA utr-variant-3-prime
rs208794 -- 38,894,236(-) ATCCC(C/T)AGGGA intron-variant
rs208795 -- 38,884,055(-) TCCAC(A/G)CCTTC intron-variant
rs208796 -- 38,884,006(-) AAGCC(C/G)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R16B Gene

Variant ID Type Subtype PubMed ID
dgv4568n71 CNV Loss 21882294
nsv3373 CNV Insertion 18451855
esv2722402 CNV Deletion 23290073
esv2722403 CNV Deletion 23290073
nsv3374 CNV Loss 18451855
esv2674770 CNV Deletion 23128226

Relevant External Links for PPP1R16B Gene

HapMap Linkage Disequilibrium report
PPP1R16B

Disorders for PPP1R16B Gene

Relevant External Links for PPP1R16B

Genetic Association Database (GAD)
PPP1R16B
genes like me logo Genes that share disorders with PPP1R16B: view

No data available for UniProtKB/Swiss-Prot for PPP1R16B Gene

Publications for PPP1R16B Gene

  1. TIMAP is a positive regulator of pulmonary endothelial barrier function. (PMID: 18586956) Csortos C. … Verin A.D. (Am. J. Physiol. 2008) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. (PMID: 12055102) Cao W. … Ballermann B.J. (Am. J. Physiol. 2002) 2 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Alternative splice variants encoding unstable protein domains exist in the human brain. (PMID: 15491607) Homma K. … Nishikawa K. (J. Mol. Biol. 2004) 3 4

Products for PPP1R16B Gene

Sources for PPP1R16B Gene

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