Aliases for PPP1R16B Gene
External Ids for PPP1R16B Gene
Previous GeneCards Identifiers for PPP1R16B Gene
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
GeneCards Summary for PPP1R16B Gene
PPP1R16B (Protein Phosphatase 1 Regulatory Subunit 16B) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase binding and protein phosphatase type 1 regulator activity. An important paralog of this gene is PPP1R12C.
UniProtKB/Swiss-Prot for PPP1R16B Gene
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.