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PPP1R16B Gene

protein-coding   GIFtS: 51
GCID: GC20P037434

Protein Phosphatase 1, Regulatory Subunit 16B

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 16B)
  Search for PPP1R16B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 16B1 2     CAAX Box Protein TIMAP2 3
TGF-Beta-Inhibited Membrane-Associated Protein1 2 3     hTIMAP2 3
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16B1 2     TIMAP2 5
Ankyrin Repeat Domain Protein 41 2     KIAA08233 5
Ankyrin Repeat Domain-Containing Protein 42 3     Protein Phosphatase 1 Regulatory Inhibitor Subunit 16B2
ANKRD42 3     

External Ids:    HGNC: 158501   Entrez Gene: 260512   Ensembl: ENSG000001014457   OMIM: 6132755   UniProtKB: Q96T493   

Export aliases for PPP1R16B gene to outside databases

Previous GC identifers: GC20P037162 GC20P038072 GC20P038119 GC20P036867 GC20P034171


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R16B Gene:
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein
phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is
inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain
and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced
transcript variants encoding different isoforms have been identified in this gene.(provided by RefSeq, Feb 2010)

GeneCards Summary for PPP1R16B Gene:
PPP1R16B (protein phosphatase 1, regulatory subunit 16B) is a protein-coding gene. GO annotations related to this gene include protein phosphatase binding. An important paralog of this gene is PPP1R13B.

UniProtKB/Swiss-Prot: PP16B_HUMAN, Q96T49
Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell
(EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier
protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn
facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia
extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R16B gene promoter:
         AREB6   Pax-5   Brachyury   Olf-1   STAT3   XBP-1   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R16B promoter sequence
   Search Chromatin IP Primers for PPP1R16B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R16B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

PPP1R16B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R16B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037434:  view genomic region     (about GC identifiers)

Start:
37,434,348 bp from pter      End:
37,551,667 bp from pter
Size:
117,320 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PP16B_HUMAN, Q96T49 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory inhibitor subunit 16B precursor  
Size: 567 amino acids; 63551 Da
Subunit: Interacts with PPP1CA, PPP1CB and MSN. Interacts (via its fourth ankyrin repeat) with the mature dimeric
form of RPSA/LAMR1
Sequence caution: Sequence=BAA74846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RRR6 E9PFS8 O94912 Q5W9G4 Q9NQG4
Alternative splicing: 2 isoforms:  Q96T49-1   Q96T49-2   

Explore the universe of human proteins at neXtProt for PPP1R16B: NX_Q96T49

Explore proteomics data for PPP1R16B at MOPED

Post-translational modifications: 

  • Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C
    and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C,
    but reduced PP1C activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R16B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166206.1  NP_056383.1  

    ENSEMBL proteins: 
     ENSP00000299824   ENSP00000362428  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR017417 Pase-1_reg_su_16AB_euk
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96T49

    ProtoNet protein and cluster: Q96T49

    UniProtKB/Swiss-Prot: PP16B_HUMAN, Q96T49
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with PPP1R16B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP16B_HUMAN, Q96T49
    Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell
    (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier
    protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn
    facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia
    extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells
    Induction: Inhibited by TGFB1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16263087
    GO:0019903protein phosphatase binding NAS12055102
         
    Find genes that share ontologies with PPP1R16B           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPP1R16B:
     Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased apoptosis 
     Wnt reporter downregulated 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp1r16b):
     immune system  normal 

    Find genes that share phenotypes with PPP1R16B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppp1r16btm1Ccb for PPP1R16B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP16B_HUMAN, Q96T49: Cell membrane. Cell membrane; Lipid-anchor (Potential). Nucleus. Note=Colocalizes with
    RPSA/LAMR1 in the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18586956
    GO:0005886plasma membrane NAS12055102

    Find genes that share ontologies with PPP1R16B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP1R16B
    Interactions:

        Search GeneGlobe Interaction Network for PPP1R16B

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for PPP1R16B (ENSP000002998244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C2orf43ENSP000002378224STRING: ENSP00000237822
    PPP1CAENSP000003260314STRING: ENSP00000326031
    PPP1CBENSP000002961224STRING: ENSP00000296122
    PPP1CCENSP000003350844STRING: ENSP00000335084
    EPHX1ENSP000002721674STRING: ENSP00000272167
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS12055102
    GO:0051489regulation of filopodium assembly ISS--

    Find genes that share ontologies with PPP1R16B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for PPP1R16B (PP16B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1R16B gene (2 alternative transcripts): 
    NM_001172735.1  NM_015568.2  

    Unigene Cluster for PPP1R16B:

    Protein phosphatase 1, regulatory subunit 16B
    Hs.45719  [show with all ESTs]
    Unigene Representative Sequence: BC152467
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299824(uc002xje.3) ENST00000373331(uc010ggb.1 uc010ggc.3)
    ENST00000468265 ENST00000463749
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    hsa-miR-642a hsa-miR-1224-3p hsa-miR-4267 hsa-miR-3142 hsa-miR-508-5p hsa-miR-3116 hsa-miR-4273 hsa-miR-525-3p
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    Additional mRNA sequence: 

    AB020630.2 AB177855.1 AF362910.1 AK311244.1 BC026224.1 BC131801.1 BC152467.1 

    8 DOTS entries:

    DT.441178  DT.120825266  DT.100728218  DT.120825239  DT.91878182  DT.91936321  DT.92039791  DT.95131823 

    4 AceView cDNA sequences:

    BQ894802 AK026900 BE748786 BE748489 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:              -     -     -                                                                     
    SP2:                                                                    -                           
    SP3:                    -                                                                           
    SP4:              -                                                                                 


    ECgene alternative splicing isoforms for PPP1R16B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R16B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGAGT
    PPP1R16B Expression
    About this image


    PPP1R16B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Positive Thymocytes Thymus
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             Thymus
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             Oligodendrocyte-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
    PPP1R16B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R16B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.45719

    UniProtKB/Swiss-Prot: PP16B_HUMAN, Q96T49
    Tissue specificity: Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R16B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r16b1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 90.06(n)1
    96.47(a)1
      2 (78.72 cM)5
    2288521  NM_153089.41  NP_694729.11 
     1586653985 
    chicken
    (Gallus gallus)
    Aves PPP1R16B1 protein phosphatase 1, regulatory subunit 16B 76.21(n)
    78.09(a)
      419170  NM_001030851.1  NP_001026022.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R16B6
    protein phosphatase 1, regulatory subunit 16B
    75(a)
    1 ↔ 1
    4(140966496-141087361)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppp1r16b1 protein phosphatase 1, regulatory subunit 16B 64.21(n)
    59.92(a)
      100170500  NM_001130280.1  NP_001123752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7997711 protein phosphatase 1 regulatory inhibitor subunit more 64.23(n)
    63.5(a)
      799771  XM_001340056.5  XP_001340092.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68963   -- 42(a)   75D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea gfi-23 ankyrin motifs 52(a)   I(9748738-9751517)   --


    ENSEMBL Gene Tree for PPP1R16B (if available)
    TreeFam Gene Tree for PPP1R16B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R16B gene
    PPP1R13B2  PPP1R12B2  PPP1R12A2  TP53BP22  PPP1R16A2  PPP1R12C2  PPP1R13L2  
    2 SIMAP similar genes for PPP1R16B using alignment to 1 protein entry:     PP16B_HUMAN:
    PPP1R16A    PPP1R27

    Find genes that share paralogs with PPP1R16B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R16B (see all 2395)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124813521,2
    C,H--37432356(+) gcttgT/Ggctaa 2 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs1148891671,2
    F--37432390(+) CCAAAG/ATCATG 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1840682451,2
    --37432435(+) ATAGTG/TTTAGC 2 -- us2k10--------
    rs1430728031,2
    --37432514(+) GATATC/GCAGTT 2 -- us2k10--------
    rs1872462931,2
    --37432530(+) AGCACA/CATTTT 2 -- us2k10--------
    rs1922713271,2
    --37432537(+) TTTTTG/TGAAAA 2 -- us2k10--------
    rs799299271,2
    F--37432625(+) GGACTC/GTCAGT 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs114782841,2
    C--37432661(+) TCCTT-/ATACCC 2 -- us2k10--------
    rs1482314011,2
    --37432665(+) TATACC/TCGTAC 2 -- us2k10--------
    rs1154462821,2
    F--37432734(+) CCCCAA/GCTTAT 2 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for PPP1R16B (37434348 - 37551667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PPP1R16B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722402CNV Deletion23290073
    esv2674770CNV Deletion23128226
    esv2722403CNV Deletion23290073
    nsv3373CNV Insertion18451855
    nsv3374CNV Loss18451855
    dgv4568n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613275    OMIM disorders: --


    Find genes that share disorders with PPP1R16B           About GenesLikeMe

    Genetic Association Database (GAD): PPP1R16B

    Export disorders for PPP1R16B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R16B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with PPP1R16B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. (PubMed id 12055102)1, 2, 3 Cao W.... Ballermann B.J. (Am. J. Physiol. 2002)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. TIMAP is a positive regulator of pulmonary endothelial barrier function. (PubMed id 18586956)1, 2, 9 Csortos C.... Verin A.D. (Am. J. Physiol. 2008)
    4. The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation. (PubMed id 16263087)1, 2 Kim K.... Ballermann B.J. (Biochem. Biophys. Res. Commun. 2005)
    5. Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)1, 2 Homma K.... Nishikawa K. (J. Mol. Biol. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1. (PubMed id 21466834)1 Czikora I....Csortos C. (Biochimie 2011)
    9. TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS. (PubMed id 21907835)1 Poirier C....Verin A.D. (amp 2011)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26051 HGNC: 15850 AceView: PPP1R16B.1 Ensembl:ENSG00000101445 euGenes: HUgn26051
    ECgene: PPP1R16B H-InvDB: PPP1R16B

    (According to HUGE)
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    HUGE: KIAA0823

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R16B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R16B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R16B gene:
    Search GeneIP for patents involving PPP1R16B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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