Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R16B Gene

Aliases for PPP1R16B Gene

  • Protein Phosphatase 1 Regulatory Subunit 16B 2 3 5
  • TGF-Beta-Inhibited Membrane-Associated Protein 2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16B 2 3
  • Protein Phosphatase 1, Regulatory Subunit 16B 2 3
  • Ankyrin Repeat Domain-Containing Protein 4 3 4
  • Ankyrin Repeat Domain Protein 4 2 3
  • CAAX Box Protein TIMAP 3 4
  • ANKRD4 3 4
  • HTIMAP 3 4
  • KIAA0823 4
  • TIMAP 3

External Ids for PPP1R16B Gene

Previous GeneCards Identifiers for PPP1R16B Gene

  • GC20P037162
  • GC20P038072
  • GC20P038119
  • GC20P036867
  • GC20P037434
  • GC20P034171

Summaries for PPP1R16B Gene

Entrez Gene Summary for PPP1R16B Gene

  • The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

GeneCards Summary for PPP1R16B Gene

PPP1R16B (Protein Phosphatase 1 Regulatory Subunit 16B) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase binding and protein phosphatase type 1 regulator activity. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R16B Gene

  • Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R16B Gene

Genomics for PPP1R16B Gene

Regulatory Elements for PPP1R16B Gene

Enhancers for PPP1R16B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R16B on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R16B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R16B on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R16B Gene

Chromosome:
20
Start:
38,805,705 bp from pter
End:
38,923,024 bp from pter
Size:
117,320 bases
Orientation:
Plus strand

Genomic View for PPP1R16B Gene

Genes around PPP1R16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R16B Gene

Proteins for PPP1R16B Gene

  • Protein details for PPP1R16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T49-PP16B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory inhibitor subunit 16B
    Protein Accession:
    Q96T49
    Secondary Accessions:
    • A2RRR6
    • E9PFS8
    • O94912
    • Q5W9G4
    • Q9NQG4

    Protein attributes for PPP1R16B Gene

    Size:
    567 amino acids
    Molecular mass:
    63551 Da
    Quaternary structure:
    • Interacts with PPP1CA, PPP1CB and MSN. Interacts (via its fourth ankyrin repeat) with the mature dimeric form of RPSA/LAMR1.
    SequenceCaution:
    • Sequence=BAA74846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R16B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R16B Gene

Proteomics data for PPP1R16B Gene at MOPED

Post-translational modifications for PPP1R16B Gene

  • Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R16B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R16B Gene

Domains & Families for PPP1R16B Gene

Protein Domains for PPP1R16B Gene

Suggested Antigen Peptide Sequences for PPP1R16B Gene

Graphical View of Domain Structure for InterPro Entry

Q96T49

UniProtKB/Swiss-Prot:

PP16B_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with PPP1R16B: view

Function for PPP1R16B Gene

Molecular function for PPP1R16B Gene

UniProtKB/Swiss-Prot Function:
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
UniProtKB/Swiss-Prot Induction:
Inhibited by TGFB1.
genes like me logo Genes that share phenotypes with PPP1R16B: view

Animal Models for PPP1R16B Gene

MGI Knock Outs for PPP1R16B:

Animal Model Products

CRISPR Products

miRNA for PPP1R16B Gene

miRTarBase miRNAs that target PPP1R16B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R16B Gene

Localization for PPP1R16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16B Gene

Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Note=Colocalizes with RPSA/LAMR1 in the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R16B Gene COMPARTMENTS Subcellular localization image for PPP1R16B gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PPP1R16B Gene

Pathways & Interactions for PPP1R16B Gene

SuperPathways for PPP1R16B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035308 negative regulation of protein dephosphorylation IDA 21466834
GO:0051489 regulation of filopodium assembly ISS --
GO:0061028 establishment of endothelial barrier IMP 18586956
genes like me logo Genes that share ontologies with PPP1R16B: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R16B Gene

Drugs & Compounds for PPP1R16B Gene

No Compound Related Data Available

Transcripts for PPP1R16B Gene

mRNA/cDNA for PPP1R16B Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R16B Gene

Protein phosphatase 1, regulatory subunit 16B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: -
SP3: -
SP4: -

Relevant External Links for PPP1R16B Gene

GeneLoc Exon Structure for
PPP1R16B
ECgene alternative splicing isoforms for
PPP1R16B

Expression for PPP1R16B Gene

mRNA expression in normal human tissues for PPP1R16B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R16B Gene

This gene is overexpressed in Brain - Cortex (x4.8), Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Putamen (basal ganglia) (x4.6), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for PPP1R16B Gene

This gene is overexpressed in Frontal cortex (36.7) and Blymphocyte (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPP1R16B Gene



SOURCE GeneReport for Unigene cluster for PPP1R16B Gene Hs.45719

mRNA Expression by UniProt/SwissProt for PPP1R16B Gene

Q96T49-PP16B_HUMAN
Tissue specificity: Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.
genes like me logo Genes that share expression patterns with PPP1R16B: view

Protein tissue co-expression partners for PPP1R16B Gene

- Elite partner

Primer Products

Orthologs for PPP1R16B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R16B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R16B 35
  • 91.18 (n)
  • 97 (a)
PPP1R16B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R16B 35
  • 92.53 (n)
  • 97.35 (a)
PPP1R16B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r16b 35
  • 90.06 (n)
  • 96.47 (a)
Ppp1r16b 16
Ppp1r16b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R16B 35
  • 98.69 (n)
  • 98.68 (a)
PPP1R16B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r16b 35
  • 89.71 (n)
  • 95.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R16B 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R16B 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1R16B 35
  • 76.21 (n)
  • 78.09 (a)
PPP1R16B 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R16B 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r16b 35
  • 64.21 (n)
  • 59.92 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799771 35
  • 64.23 (n)
  • 63.5 (a)
PPP1R16B 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6896 37
  • 42 (a)
MYPT-75D 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gfi-2 37
  • 52 (a)
gfi-2 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1404 36
  • 51 (a)
OneToMany
Species with no ortholog for PPP1R16B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R16B Gene

ENSEMBL:
Gene Tree for PPP1R16B (if available)
TreeFam:
Gene Tree for PPP1R16B (if available)

Paralogs for PPP1R16B Gene

Paralogs for PPP1R16B Gene

(2) SIMAP similar genes for PPP1R16B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP1R16B: view

Variants for PPP1R16B Gene

Sequence variations from dbSNP and Humsavar for PPP1R16B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10392 -- 38,922,292(+) ATTGT(A/G)GTTGT utr-variant-3-prime
rs10477 -- 38,922,825(-) AGATC(C/T)GCGAA utr-variant-3-prime
rs450386 -- 38,855,935(+) atata(G/T)agaga intron-variant
rs208794 -- 38,894,236(-) ATCCC(C/T)AGGGA intron-variant
rs208795 -- 38,884,055(-) TCCAC(A/G)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R16B Gene

Variant ID Type Subtype PubMed ID
dgv4568n71 CNV Loss 21882294
nsv3373 CNV Insertion 18451855
esv2722402 CNV Deletion 23290073
esv2722403 CNV Deletion 23290073
nsv3374 CNV Loss 18451855
esv2674770 CNV Deletion 23128226

Variation tolerance for PPP1R16B Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R16B Gene

Disorders for PPP1R16B Gene

Relevant External Links for PPP1R16B

Genetic Association Database (GAD)
PPP1R16B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R16B

No disorders were found for PPP1R16B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R16B Gene

Publications for PPP1R16B Gene

  1. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. (PMID: 12055102) Cao W. … Ballermann B.J. (Am. J. Physiol. 2002) 2 3 4 67
  2. TIMAP is a positive regulator of pulmonary endothelial barrier function. (PMID: 18586956) Csortos C. … Verin A.D. (Am. J. Physiol. 2008) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  4. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. (PMID: 25007873) Obeidat M. … Ballermann B.J. (Am. J. Physiol. Renal Physiol. 2014) 3
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3

Products for PPP1R16B Gene

Sources for PPP1R16B Gene

Content