Aliases for PPP1R16A Gene
External Ids for PPP1R16A Gene
Previous GeneCards Identifiers for PPP1R16A Gene
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016]
GeneCards Summary for PPP1R16A Gene
PPP1R16A (Protein Phosphatase 1 Regulatory Subunit 16A) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include actin binding. An important paralog of this gene is PPP1R16B.
UniProtKB/Swiss-Prot for PPP1R16A Gene
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.