Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R16A Gene

Aliases for PPP1R16A Gene

  • Protein Phosphatase 1 Regulatory Subunit 16A 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16A 2 3
  • Protein Phosphatase 1, Regulatory Subunit 16A 2 3
  • Myosin Phosphatase-Targeting Subunit 3 3 4
  • MYPT3 3 4
  • Likley Ortholog Of Mouse Myosin Phosphatase Targeting Subunit 3 3

External Ids for PPP1R16A Gene

Previous GeneCards Identifiers for PPP1R16A Gene

  • GC08P143416
  • GC08P145753
  • GC08P145308
  • GC08P145726
  • GC08P145692
  • GC08P145686
  • GC08P140835
  • GC08P145703

Summaries for PPP1R16A Gene

GeneCards Summary for PPP1R16A Gene

PPP1R16A (Protein Phosphatase 1 Regulatory Subunit 16A) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include actin binding and protein phosphatase type 1 regulator activity. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R16A Gene

  • Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R16A Gene

Genomics for PPP1R16A Gene

Regulatory Elements for PPP1R16A Gene

Enhancers for PPP1R16A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R16A on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R16A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R16A on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R16A Gene

144,477,969 bp from pter
144,502,121 bp from pter
24,153 bases
Plus strand

Genomic View for PPP1R16A Gene

Genes around PPP1R16A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R16A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R16A Gene

Proteins for PPP1R16A Gene

  • Protein details for PPP1R16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 16A
    Protein Accession:
    Secondary Accessions:
    • D3DWM5

    Protein attributes for PPP1R16A Gene

    528 amino acids
    Molecular mass:
    57811 Da
    Quaternary structure:
    • Binds PP1.
    • Sequence=BAC03452.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for PPP1R16A Gene

Proteomics data for PPP1R16A Gene at MOPED

Post-translational modifications for PPP1R16A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R16A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPP1R16A Gene

Domains & Families for PPP1R16A Gene

Suggested Antigen Peptide Sequences for PPP1R16A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 ANK repeats.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with PPP1R16A: view

Function for PPP1R16A Gene

Molecular function for PPP1R16A Gene

UniProtKB/Swiss-Prot Function:
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

Gene Ontology (GO) - Molecular Function for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008599 protein phosphatase type 1 regulator activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view
genes like me logo Genes that share phenotypes with PPP1R16A: view

Animal Model Products

CRISPR Products

miRNA for PPP1R16A Gene

miRTarBase miRNAs that target PPP1R16A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R16A Gene

Localization for PPP1R16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for PPP1R16A Gene COMPARTMENTS Subcellular localization image for PPP1R16A gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PPP1R16A Gene

Pathways & Interactions for PPP1R16A Gene

genes like me logo Genes that share pathways with PPP1R16A: view

Gene Ontology (GO) - Biological Process for PPP1R16A Gene


No data available for SIGNOR curated interactions for PPP1R16A Gene

Drugs & Compounds for PPP1R16A Gene

No Compound Related Data Available

Transcripts for PPP1R16A Gene

Unigene Clusters for PPP1R16A Gene

Protein phosphatase 1, regulatory subunit 16A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16A Gene

No ASD Table

Relevant External Links for PPP1R16A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R16A Gene

mRNA expression in normal human tissues for PPP1R16A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R16A Gene

This gene is overexpressed in Testis (19.2), Retina (19.1), Fetal Brain (17.8), and Liver (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R16A Gene

SOURCE GeneReport for Unigene cluster for PPP1R16A Gene Hs.521937

genes like me logo Genes that share expression patterns with PPP1R16A: view

Protein tissue co-expression partners for PPP1R16A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R16A Gene

Orthologs for PPP1R16A Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R16A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R16A 35
  • 86.28 (n)
  • 85.63 (a)
PPP1R16A 36
  • 85 (a)
(Canis familiaris)
Mammalia PPP1R16A 35
  • 86.01 (n)
  • 84.54 (a)
PPP1R16A 36
  • 84 (a)
(Mus musculus)
Mammalia Ppp1r16a 35
  • 82.19 (n)
  • 82.63 (a)
Ppp1r16a 16
Ppp1r16a 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Ppp1r16a 35
  • 82.12 (n)
  • 83.21 (a)
(Monodelphis domestica)
Mammalia PPP1R16A 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R16A 36
  • 68 (a)
(Anolis carolinensis)
Reptilia PPP1R16A 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r16a 35
  • 65.97 (n)
  • 60.99 (a)
(Danio rerio)
Actinopterygii si:dkey-9l5.3 35
  • 57.69 (n)
  • 58.08 (a)
PPP1R16A 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6896 37
  • 42 (a)
MYPT-75D 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea gfi-2 37
  • 49 (a)
gfi-2 35
  • 49.56 (n)
  • 48.68 (a)
gfi-2 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1404 36
  • 51 (a)
Species with no ortholog for PPP1R16A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R16A Gene

Gene Tree for PPP1R16A (if available)
Gene Tree for PPP1R16A (if available)

Paralogs for PPP1R16A Gene

Paralogs for PPP1R16A Gene

(1) SIMAP similar genes for PPP1R16A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPP1R16A: view

Variants for PPP1R16A Gene

Sequence variations from dbSNP and Humsavar for PPP1R16A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2086362 -- 144,492,239(+) ACTTC(C/T)CTCTG intron-variant
rs2251727 -- 144,492,358(+) TGATA(G/T)GGAGT intron-variant
rs2620633 -- 144,486,673(-) gatgc(A/G)aagac intron-variant
rs2620634 -- 144,484,487(-) CAGCC(C/G)TAGAC intron-variant
rs2620635 -- 144,483,737(-) ggcaa(C/T)agagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R16A Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891846 CNV Loss 21882294
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv29999 CNV Loss 17803354
nsv891911 CNV Loss 21882294
nsv891912 CNV Loss 21882294
dgv7981n71 CNV Loss 21882294
dgv7982n71 CNV Loss 21882294
nsv482126 CNV Gain 20164927
dgv7983n71 CNV Loss 21882294
dgv1207n67 CNV Gain 20364138
dgv7984n71 CNV Loss 21882294

Variation tolerance for PPP1R16A Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R16A Gene

Disorders for PPP1R16A Gene

Relevant External Links for PPP1R16A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R16A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R16A Gene

Publications for PPP1R16A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for PPP1R16A Gene

Sources for PPP1R16A Gene