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Aliases for PPP1R16A Gene

Aliases for PPP1R16A Gene

  • Protein Phosphatase 1, Regulatory Subunit 16A 2 3
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16A 2 3
  • Myosin Phosphatase-Targeting Subunit 3 3 4
  • MYPT3 3 4
  • Likley Ortholog Of Mouse Myosin Phosphatase Targeting Subunit 3 3
  • Protein Phosphatase 1 Regulatory Subunit 16A 3

External Ids for PPP1R16A Gene

Previous GeneCards Identifiers for PPP1R16A Gene

  • GC08P143416
  • GC08P145753
  • GC08P145308
  • GC08P145726
  • GC08P145692
  • GC08P145686
  • GC08P140835
  • GC08P145703

Summaries for PPP1R16A Gene

GeneCards Summary for PPP1R16A Gene

PPP1R16A (Protein Phosphatase 1, Regulatory Subunit 16A) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R16A Gene

  • Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R16A Gene

Genomics for PPP1R16A Gene

Regulatory Elements for PPP1R16A Gene

Genomic Location for PPP1R16A Gene

144,477,969 bp from pter
144,502,121 bp from pter
24,153 bases
Plus strand

Genomic View for PPP1R16A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R16A Gene

Proteins for PPP1R16A Gene

  • Protein details for PPP1R16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 16A
    Protein Accession:
    Secondary Accessions:
    • D3DWM5

    Protein attributes for PPP1R16A Gene

    528 amino acids
    Molecular mass:
    57811 Da
    Quaternary structure:
    • Binds PP1
    • Sequence=BAC03452.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for PPP1R16A Gene

Proteomics data for PPP1R16A Gene at MOPED

Post-translational modifications for PPP1R16A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R16A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPP1R16A Gene

Domains for PPP1R16A Gene

Gene Families for PPP1R16A Gene

  • ANKRD :Ankyrin repeat domain containing
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Suggested Antigen Peptide Sequences for PPP1R16A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96I34
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with PPP1R16A: view

Function for PPP1R16A Gene

Molecular function for PPP1R16A Gene

UniProtKB/Swiss-Prot Function: Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

Gene Ontology (GO) - Molecular Function for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005515 protein binding IPI 16169070
GO:0008599 protein phosphatase type 1 regulator activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

Phenotypes for PPP1R16A Gene

GenomeRNAi human phenotypes for PPP1R16A:
genes like me logo Genes that share phenotypes with PPP1R16A: view

Animal Model Products

CRISPR Products

miRNA for PPP1R16A Gene

miRTarBase miRNAs that target PPP1R16A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R16A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1R16A Gene

Localization for PPP1R16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for PPP1R16A Gene COMPARTMENTS Subcellular localization image for PPP1R16A gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

Pathways for PPP1R16A Gene

genes like me logo Genes that share pathways with PPP1R16A: view

Gene Ontology (GO) - Biological Process for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

Transcripts for PPP1R16A Gene

Unigene Clusters for PPP1R16A Gene

Protein phosphatase 1, regulatory subunit 16A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R16A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16A Gene

No ASD Table

Relevant External Links for PPP1R16A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R16A Gene

mRNA expression in normal human tissues for PPP1R16A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R16A Gene

SOURCE GeneReport for Unigene cluster for PPP1R16A Gene Hs.521937

genes like me logo Genes that share expressions with PPP1R16A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R16A Gene

Orthologs for PPP1R16A Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R16A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R16A 35
  • 86.28 (n)
  • 85.63 (a)
PPP1R16A 36
  • 85 (a)
(Canis familiaris)
Mammalia PPP1R16A 35
  • 86.01 (n)
  • 84.54 (a)
PPP1R16A 36
  • 84 (a)
(Mus musculus)
Mammalia Ppp1r16a 35
  • 82.19 (n)
  • 82.63 (a)
Ppp1r16a 16
Ppp1r16a 36
  • 82 (a)
(Monodelphis domestica)
Mammalia PPP1R16A 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R16A 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Ppp1r16a 35
  • 82.12 (n)
  • 83.21 (a)
(Anolis carolinensis)
Reptilia PPP1R16A 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r16a 35
  • 65.97 (n)
  • 60.99 (a)
(Danio rerio)
Actinopterygii PPP1R16A 36
  • 53 (a)
si:dkey-9l5.3 35
  • 57.69 (n)
  • 58.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta MYPT-75D 36
  • 29 (a)
CG6896 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea gfi-2 35
  • 49.56 (n)
  • 48.68 (a)
gfi-2 36
  • 36 (a)
gfi-2 37
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1404 36
  • 51 (a)
Species with no ortholog for PPP1R16A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R16A Gene

Gene Tree for PPP1R16A (if available)
Gene Tree for PPP1R16A (if available)

Paralogs for PPP1R16A Gene

Paralogs for PPP1R16A Gene

Selected SIMAP similar genes for PPP1R16A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPP1R16A: view

Variants for PPP1R16A Gene

Sequence variations from dbSNP and Humsavar for PPP1R16A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1044618 -- 144,502,008(+) GGCTT(C/T)TACTG utr-variant-3-prime
rs1055167 -- 144,485,003(+) CTCAC(A/G)CCTGT intron-variant
rs1871542 -- 144,500,576(+) GACGG(C/T)TGGGA reference, synonymous-codon
rs1871543 -- 144,500,774(+) TGCGG(A/G)GCCCA intron-variant
rs1871544 -- 144,500,807(+) GGCGG(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R16A Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891846 CNV Loss 21882294
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv29999 CNV Loss 17803354
nsv891911 CNV Loss 21882294
nsv891912 CNV Loss 21882294
dgv7981n71 CNV Loss 21882294
dgv7982n71 CNV Loss 21882294
nsv482126 CNV Gain 20164927
dgv7983n71 CNV Loss 21882294
dgv1207n67 CNV Gain 20364138
dgv7984n71 CNV Loss 21882294

Relevant External Links for PPP1R16A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R16A Gene

Disorders for PPP1R16A Gene

No disorders were found for PPP1R16A Gene.

No data available for UniProtKB/Swiss-Prot for PPP1R16A Gene

Publications for PPP1R16A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. (PMID: 11336659) Skinner J.A. … Saltiel A.R. (Biochem. J. 2001) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for PPP1R16A Gene

  • antibodies-online proteins for PPP1R16A
  • antibodies-online antibodies for PPP1R16A
  • antibodies-online kits for PPP1R16A

Sources for PPP1R16A Gene

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