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Aliases for PPP1R15B Gene

Aliases for PPP1R15B Gene

  • Protein Phosphatase 1 Regulatory Subunit 15B 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15B 2 3
  • Protein Phosphatase 1, Regulatory Subunit 15B 2
  • MSSGM2 3
  • CREP 3

External Ids for PPP1R15B Gene

Previous GeneCards Identifiers for PPP1R15B Gene

  • GC01M202101
  • GC01M199833
  • GC01M200736
  • GC01M201552
  • GC01M201549
  • GC01M201104
  • GC01M202639
  • GC01M175537

Summaries for PPP1R15B Gene

Entrez Gene Summary for PPP1R15B Gene

  • This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]

GeneCards Summary for PPP1R15B Gene

PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) is a Protein Coding gene. Diseases associated with PPP1R15B include microcephaly, short stature, and impaired glucose metabolism. GO annotations related to this gene include protein serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for PPP1R15B Gene

  • Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R15B Gene

Genomics for PPP1R15B Gene

Regulatory Elements for PPP1R15B Gene

Genomic Location for PPP1R15B Gene

Chromosome:
1
Start:
204,400,275 bp from pter
End:
204,411,817 bp from pter
Size:
11,543 bases
Orientation:
Minus strand

Genomic View for PPP1R15B Gene

Genes around PPP1R15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R15B Gene

Proteins for PPP1R15B Gene

  • Protein details for PPP1R15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWA1-PR15B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 15B
    Protein Accession:
    Q5SWA1
    Secondary Accessions:
    • Q53GQ4
    • Q658M2
    • Q6P156
    • Q96SN1

    Protein attributes for PPP1R15B Gene

    Size:
    713 amino acids
    Molecular mass:
    79152 Da
    Quaternary structure:
    • Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PP1.
    Miscellaneous:
    • The phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.

    Three dimensional structures from OCA and Proteopedia for PPP1R15B Gene

neXtProt entry for PPP1R15B Gene

Proteomics data for PPP1R15B Gene at MOPED

Post-translational modifications for PPP1R15B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R15B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R15B Gene

Domains & Families for PPP1R15B Gene

Gene Families for PPP1R15B Gene

Protein Domains for PPP1R15B Gene

Suggested Antigen Peptide Sequences for PPP1R15B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SWA1

UniProtKB/Swiss-Prot:

PR15B_HUMAN :
  • Belongs to the PPP1R15 family.
Family:
  • Belongs to the PPP1R15 family.
genes like me logo Genes that share domains with PPP1R15B: view

Function for PPP1R15B Gene

Molecular function for PPP1R15B Gene

UniProtKB/Swiss-Prot Function:
Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.
genes like me logo Genes that share phenotypes with PPP1R15B: view

Animal Models for PPP1R15B Gene

MGI Knock Outs for PPP1R15B:

Animal Model Products

CRISPR Products

miRNA for PPP1R15B Gene

miRTarBase miRNAs that target PPP1R15B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R15B Gene

Localization for PPP1R15B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R15B Gene COMPARTMENTS Subcellular localization image for PPP1R15B gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R15B Gene

Pathways & Interactions for PPP1R15B Gene

SuperPathways for PPP1R15B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006983 ER overload response IEA --
GO:0070262 peptidyl-serine dephosphorylation IEA,ISS --
GO:1903898 negative regulation of PERK-mediated unfolded protein response TAS 22013210
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with PPP1R15B: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R15B Gene

Drugs & Compounds for PPP1R15B Gene

No Compound Related Data Available

Transcripts for PPP1R15B Gene

mRNA/cDNA for PPP1R15B Gene

Unigene Clusters for PPP1R15B Gene

Protein phosphatase 1, regulatory subunit 15B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R15B Gene

No ASD Table

Relevant External Links for PPP1R15B Gene

GeneLoc Exon Structure for
PPP1R15B
ECgene alternative splicing isoforms for
PPP1R15B

Expression for PPP1R15B Gene

mRNA expression in normal human tissues for PPP1R15B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R15B Gene

This gene is overexpressed in Pancreatic juice (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R15B Gene



SOURCE GeneReport for Unigene cluster for PPP1R15B Gene Hs.304376

genes like me logo Genes that share expression patterns with PPP1R15B: view

Protein tissue co-expression partners for PPP1R15B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R15B Gene

Orthologs for PPP1R15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R15B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R15B 35
  • 99.39 (n)
  • 98.6 (a)
PPP1R15B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R15B 36
  • 75 (a)
OneToOne
PPP1R15B 35
  • 82.9 (n)
  • 75.21 (a)
dog
(Canis familiaris)
Mammalia PPP1R15B 35
  • 77.79 (n)
  • 67.35 (a)
PPP1R15B 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r15b 16
Ppp1r15b 36
  • 69 (a)
OneToOne
Ppp1r15b 35
  • 78.33 (n)
  • 70.57 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R15B 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R15B 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r15b 35
  • 78.09 (n)
  • 70.44 (a)
chicken
(Gallus gallus)
Aves PPP1R15B 35
  • 59.47 (n)
  • 53.47 (a)
PPP1R15B 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R15B 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP1R15B 36
  • 23 (a)
OneToOne
Species with no ortholog for PPP1R15B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R15B Gene

ENSEMBL:
Gene Tree for PPP1R15B (if available)
TreeFam:
Gene Tree for PPP1R15B (if available)

Paralogs for PPP1R15B Gene

No data available for Paralogs for PPP1R15B Gene

Variants for PPP1R15B Gene

Sequence variations from dbSNP and Humsavar for PPP1R15B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12094135 - 204,411,336(+) CCGAG(A/G)GAAAA reference, missense
rs4492688 - 204,410,982(+) CTCCT(C/T)TAGCC reference, missense
rs3014626 - 204,410,489(+) CCTTG(C/T)TAGCC reference, missense
rs2089891 - 204,410,324(-) TGAAG(A/G)AAAAA reference, missense
rs17855962 - 204,409,647(+) GGTCT(C/T)TGAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PPP1R15B Gene

Variant ID Type Subtype PubMed ID
nsv826409 CNV Loss 20364138

Variation tolerance for PPP1R15B Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 54.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R15B Gene

HapMap Linkage Disequilibrium report
PPP1R15B
Human Gene Mutation Database (HGMD)
PPP1R15B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R15B Gene

Disorders for PPP1R15B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R15B Gene - From: GeneCards

Disorder Aliases PubMed IDs
microcephaly, short stature, and impaired glucose metabolism
  • microcephaly, short stature, and impaired glucose metabolism 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP1R15B

Genetic Association Database (GAD)
PPP1R15B
Human Genome Epidemiology (HuGE) Navigator
PPP1R15B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R15B
genes like me logo Genes that share disorders with PPP1R15B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R15B Gene

Publications for PPP1R15B Gene

  1. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PPP1R15B Gene

Sources for PPP1R15B Gene

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