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Aliases for PPP1R15A Gene

Aliases for PPP1R15A Gene

  • Protein Phosphatase 1 Regulatory Subunit 15A 2 3 5
  • Myeloid Differentiation Primary Response Protein MyD116 Homolog 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A 2 3
  • Growth Arrest And DNA Damage-Inducible Protein GADD34 3 4
  • Growth Arrest And DNA-Damage-Inducible 34 2 3
  • GADD34 3 4
  • Protein Phosphatase 1, Regulatory Subunit 15A 2

External Ids for PPP1R15A Gene

Previous GeneCards Identifiers for PPP1R15A Gene

  • GC19P050033
  • GC19P049743
  • GC19P054051
  • GC19P054067
  • GC19P049375
  • GC19P045752

Summaries for PPP1R15A Gene

Entrez Gene Summary for PPP1R15A Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

CIViC summary for PPP1R15A Gene

GeneCards Summary for PPP1R15A Gene

PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) is a Protein Coding gene. Diseases associated with PPP1R15A include Malignant Pleural Mesothelioma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for PPP1R15A Gene

  • Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on Ser-15.

Gene Wiki entry for PPP1R15A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R15A Gene

Genomics for PPP1R15A Gene

Regulatory Elements for PPP1R15A Gene

Enhancers for PPP1R15A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048958 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.5 +91.6 91638 10.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPP1R15A PRR12 NUP62 IZUMO1 RUVBL2 CA11 SEC1P SNORD35B C19orf68 ALDH16A1
GH19G049207 1.6 FANTOM5 Ensembl ENCODE 14.9 +335.9 335940 1.4 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF121 FOS SP5 PPP1R15A CD37 SNRNP70 C19orf73 PPFIA3 LIN7B NTF4 CGB7 SLC6A16 KCNA7
GH19G048898 1.1 ENCODE 12.2 +27.9 27850 3.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NUCB1 TULP2 PPP1R15A PLEKHA4 BAX FTL DBP SEC1P IRF3 NUCB1-AS1
GH19G048924 1.6 FANTOM5 Ensembl ENCODE 7.6 +53.9 53913 3.4 HDGF ATF1 PKNOX1 CREB3L1 ARNT AGO1 SIN3A ZNF121 GLIS2 FOS NUCB1 PPP1R15A IZUMO1 FTL GC19P048927 ENSG00000260366
GH19G048844 0.9 ENCODE 12.1 -27.8 -27754 0.2 ATF1 CREB3L1 RAD21 YY1 ZSCAN5C ZNF143 CREM THAP11 NFYA YY2 PLEKHA4 PPP1R15A TULP2 BCAT2 NUCB1 NUCB1-AS1 CGB7 NTF4 GC19P048839 GC19P048838
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R15A on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R15A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110793 1508 3401 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 ZNF610

Genomic Location for PPP1R15A Gene

Chromosome:
19
Start:
48,872,392 bp from pter
End:
48,876,062 bp from pter
Size:
3,671 bases
Orientation:
Plus strand

Genomic View for PPP1R15A Gene

Genes around PPP1R15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R15A Gene

Proteins for PPP1R15A Gene

  • Protein details for PPP1R15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75807-PR15A_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 15A
    Protein Accession:
    O75807
    Secondary Accessions:
    • B4DKQ3
    • Q6IA96
    • Q9NVU6

    Protein attributes for PPP1R15A Gene

    Size:
    674 amino acids
    Molecular mass:
    73478 Da
    Quaternary structure:
    • Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.
    Miscellaneous:
    • The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.

    Three dimensional structures from OCA and Proteopedia for PPP1R15A Gene

    Alternative splice isoforms for PPP1R15A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R15A Gene

Post-translational modifications for PPP1R15A Gene

  • Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2.
  • Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R15A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R15A Gene

Domains & Families for PPP1R15A Gene

Gene Families for PPP1R15A Gene

Protein Domains for PPP1R15A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75807

UniProtKB/Swiss-Prot:

PR15A_HUMAN :
  • Belongs to the PPP1R15 family.
Family:
  • Belongs to the PPP1R15 family.
genes like me logo Genes that share domains with PPP1R15A: view

Function for PPP1R15A Gene

Molecular function for PPP1R15A Gene

UniProtKB/Swiss-Prot Function:
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on Ser-15.
UniProtKB/Swiss-Prot Induction:
By methyl methanesulfonate and ionizing irradiation. By IL24/interleukin-24 in melanoma cells; which induces apoptosis.

Gene Ontology (GO) - Molecular Function for PPP1R15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11564868
GO:0008157 protein phosphatase 1 binding IPI 12556489
GO:0019888 protein phosphatase regulator activity IC 11564868
GO:0019901 protein kinase binding IPI 11517336
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with PPP1R15A: view
genes like me logo Genes that share phenotypes with PPP1R15A: view

Animal Models for PPP1R15A Gene

MGI Knock Outs for PPP1R15A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R15A Gene

Localization for PPP1R15A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R15A Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269 PubMed:21518769}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R15A gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 4
nucleus 1

Gene Ontology (GO) - Cellular Components for PPP1R15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IDA 11564868
GO:0005737 cytoplasm IDA 21518769
GO:0005739 mitochondrion IDA 21518769
GO:0005741 mitochondrial outer membrane IEA --
GO:0005783 endoplasmic reticulum IDA 12556489
genes like me logo Genes that share ontologies with PPP1R15A: view

Pathways & Interactions for PPP1R15A Gene

genes like me logo Genes that share pathways with PPP1R15A: view

SIGNOR curated interactions for PPP1R15A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP1R15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006915 apoptotic process TAS 9153226
GO:0006974 cellular response to DNA damage stimulus TAS 9153226
GO:0007050 cell cycle arrest TAS 9153226
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PPP1R15A: view

Drugs & Compounds for PPP1R15A Gene

(10) Drugs for PPP1R15A Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sephin1 Pharma Selective PPP1R15A inhibitor 0

(4) Additional Compounds for PPP1R15A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPP1R15A Gene

Compound Action Cas Number
Sephin1 Selective PPP1R15A inhibitor 13098-73-2
genes like me logo Genes that share compounds with PPP1R15A: view

Drug Products

Transcripts for PPP1R15A Gene

mRNA/cDNA for PPP1R15A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R15A Gene

Protein phosphatase 1, regulatory subunit 15A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R15A Gene

No ASD Table

Relevant External Links for PPP1R15A Gene

GeneLoc Exon Structure for
PPP1R15A
ECgene alternative splicing isoforms for
PPP1R15A

Expression for PPP1R15A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R15A Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R15A Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for PPP1R15A Gene

This gene is overexpressed in Retina (41.0) and Testis (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R15A Gene



Protein tissue co-expression partners for PPP1R15A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R15A Gene:

PPP1R15A

SOURCE GeneReport for Unigene cluster for PPP1R15A Gene:

Hs.631593

Evidence on tissue expression from TISSUES for PPP1R15A Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Lung(3.8)
  • Pancreas(2.5)
  • Liver(2.4)
  • Bone marrow(2.3)
  • Intestine(2.3)
  • Skin(2.3)
  • Heart(2.2)
  • Muscle(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PPP1R15A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R15A Gene

Orthologs for PPP1R15A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R15A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R15A 34 35
  • 99.06 (n)
cow
(Bos Taurus)
Mammalia PPP1R15A 34 35
  • 74.81 (n)
mouse
(Mus musculus)
Mammalia Ppp1r15a 34 16 35
  • 66.77 (n)
dog
(Canis familiaris)
Mammalia PPP1R15A 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R15A 35
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppp1r15a 35
  • 24 (a)
OneToOne
Species where no ortholog for PPP1R15A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R15A Gene

ENSEMBL:
Gene Tree for PPP1R15A (if available)
TreeFam:
Gene Tree for PPP1R15A (if available)

Paralogs for PPP1R15A Gene

No data available for Paralogs for PPP1R15A Gene

Variants for PPP1R15A Gene

Sequence variations from dbSNP and Humsavar for PPP1R15A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000282316 -- 48,876,478(+) CGTTT(C/T)CACCG downstream-variant-500B
rs1000313900 -- 48,873,475(+) TGAAG(A/G)GGAGG reference, missense
rs1000659805 -- 48,870,535(+) AAAAA(-/G)AAAAA upstream-variant-2KB
rs1002696186 -- 48,873,825(+) AAGAA(A/G)CTGTA reference, missense
rs1003013536 -- 48,871,599(+) CAAGG(C/T)AGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R15A Gene

Variant ID Type Subtype PubMed ID
nsv470148 CNV gain 18288195
nsv833855 CNV loss 17160897
nsv833856 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for PPP1R15A Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.66; 98.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R15A Gene

Disorders for PPP1R15A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R15A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP1R15A

Genetic Association Database (GAD)
PPP1R15A
Human Genome Epidemiology (HuGE) Navigator
PPP1R15A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R15A
genes like me logo Genes that share disorders with PPP1R15A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R15A Gene

Publications for PPP1R15A Gene

  1. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. (PMID: 9153226) Hollander M.C. … Fornace A.J. Jr. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. (PMID: 14718519) Shi W. … Cao X. (J. Cell Biol. 2004) 3 4 22 64
  3. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. (PMID: 12556489) Brush M.H. … Shenolikar S. (Mol. Cell. Biol. 2003) 3 4 22 64
  4. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PMID: 12724406) Hung W.J. … Wu D.Y. (Mol. Cell. Biol. 2003) 3 4 22 64
  5. GADD34 induces p53 phosphorylation and p21/WAF1 transcription. (PMID: 14635196) Yagi A. … Isobe K. (J. Cell. Biochem. 2003) 3 4 22 64

Products for PPP1R15A Gene

Sources for PPP1R15A Gene

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