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PPP1R15A Gene

protein-coding   GIFtS: 59
GCID: GC19P049375

Protein Phosphatase 1, Regulatory Subunit 15A

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 15A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 15A1 2     Growth Arrest And DNA Damage-Inducible Protein GADD342 3
GADD342 3 5     Myeloid Differentiation Primary Response Protein MyD116 Homolog2 3
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A1 2     Protein Phosphatase 1 Regulatory Subunit 15A2
Growth Arrest And DNA-Damage-Inducible 341 2     

External Ids:    HGNC: 143751   Entrez Gene: 236452   Ensembl: ENSG000000870747   OMIM: 6110485   UniProtKB: O758073   

Export aliases for PPP1R15A gene to outside databases

Previous GC identifers: GC19P050033 GC19P049743 GC19P054051 GC19P054067 GC19P045752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R15A Gene:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest
conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in
certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following
ionizing radiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1R15A Gene:
PPP1R15A (protein phosphatase 1, regulatory subunit 15A) is a protein-coding gene. Diseases associated with PPP1R15A include malignant pleural mesothelioma, and tuberous sclerosis complex. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807
Function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation
factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases
and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting
dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'

Gene Wiki entry for PPP1R15A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R15A gene promoter:
         Sp1   AP-1   ATF-2   IRF-1   CREB   deltaCREB   IRF-7A   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1R15A promoter sequence
   Search Chromatin IP Primers for PPP1R15A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R15A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.2

PPP1R15A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R15A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049375:  view genomic region     (about GC identifiers)

Start:
49,375,649 bp from pter      End:
49,379,319 bp from pter
Size:
3,671 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 15A  
Size: 674 amino acids; 73478 Da
Subunit: Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and
SMARCB1. Interacts with SMAD7. Interacts with BAG1
Miscellaneous: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by
Salubrinal, a drug that protects cells from endoplasmic reticulum stress
Secondary accessions: Q6IA96 Q9NVU6

Explore the universe of human proteins at neXtProt for PPP1R15A: NX_O75807

Explore proteomics data for PPP1R15A at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R15A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055145.3  
    ENSEMBL proteins: 
     ENSP00000200453   ENSP00000469239  
    Reactome Protein details: O75807

    PPP1R15A Human Recombinant Protein Products:

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    Novus Biologicals PPP1R15A Proteins
    Novus Biologicals PPP1R15A Lysate
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    Cloud-Clone Corp. Proteins for PPP1R15A

    PPP1R15A Antibody Products:

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    Abcam antibodies for PPP1R15A
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    Cloud-Clone Corp. CLIAs for PPP1R15A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR019523 Prot_Pase1_reg-su15A/B_C

    Graphical View of Domain Structure for InterPro Entry O75807

    ProtoNet protein and cluster: O75807

    UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807
    Similarity: Belongs to the PPP1R15 family


    PPP1R15A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PR15A_HUMAN, O75807
    Function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation
    factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases
    and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting
    dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'
    Induction: By methyl methanesulfonate and ionizing irradiation. By IL24/interleukin-24 in melanoma cells; which
    induces apoptosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11564868
    GO:0019901protein kinase binding IPI11517336
         
    PPP1R15A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP1R15A:
     Decreased melanin production 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppp1r15a):
     cellular  growth/size/body  hematopoietic system  immune system  mortality/aging 
     normal 

    PPP1R15A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PPP1R15A: Ppp1r15atm1.1Ajf Ppp1r15atm1Kii Ppp1r15atm1Dron

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1R15A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R15A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1R15A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP1R15A:
    hsa-mir-17-5p (MIRT050807)

    Block miRNA regulation of human, mouse, rat PPP1R15A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PPP1R15A:
    hsa-miR-1283
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP1R15A
    Predesigned siRNA for gene silencing in human, mouse, rat PPP1R15A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PPP1R15A

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP1R15A (NM_014330)
    Sino Biological Human cDNA Clone for PPP1R15A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R15A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R15A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R15A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PR15A_HUMAN, O75807: Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol4
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol TAS--

    PPP1R15A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R15A About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Beta-Adrenergic Signaling
    Erythropoietin Pathway0.37
    Insulin Receptor Pathway0.37
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    4TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.82
    TGF-beta receptor signaling activates SMADs0.82
    5PEDF Induced Signaling
    IL-6 Pathway0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R15A (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    2 BioSystems Pathways for PPP1R15A
        BMP receptor signaling
    TGF-beta receptor signaling


    1 Reactome Pathway for PPP1R15A
        Downregulation of TGF-beta receptor signaling


    1 Kegg Pathway  (Kegg details for PPP1R15A):
        Protein processing in endoplasmic reticulum


    PPP1R15A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP1R15A: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Unfolded Protein Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP1R15A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1R15A (O758071, 2, 3 ENSP000002004534) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0006915apoptotic process IEA--
    GO:0006974cellular response to DNA damage stimulus TAS9153226
    GO:0007050cell cycle arrest TAS9153226
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    PPP1R15A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R15A (PR15A)

    Selected Novoseek inferred chemical compound relationships for PPP1R15A gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    o6-benzylguanine 56.8 6 16325149 (3), 16391370 (2)
    thapsigargin 46.3 4 18266951 (1), 20022965 (1), 12556489 (1), 19302589 (1)
    okadaic acid 45.3 2 19776135 (1), 12556489 (1)
    methylmethanesulfonate 41 1 11104688 (1)
    tunicamycin 36.7 1 12556489 (1)
    peroxynitrite 20.9 1 11163539 (1)
    cisplatin 15.9 12 16325149 (6), 16294031 (2)
    threonine 15.4 3 11104688 (1), 12840028 (1), 11564868 (1)
    carboplatin 15.3 1 15031599 (1)
    lactate 6.1 3 16039175 (1), 17080237 (1), 16294031 (1)



    PPP1R15A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP1R15A gene: 
    NM_014330.3  

    Unigene Cluster for PPP1R15A:

    Protein phosphatase 1, regulatory subunit 15A
    Hs.631593  [show with all ESTs]
    Unigene Representative Sequence: NM_014330
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200453(uc002pky.4) ENST00000600406
    miRNA
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    hsa-miR-1283
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP1R15A
      QuantiFast Probe-based Assays in human, mouse, rat PPP1R15A

    Additional mRNA sequence: 

    AK001361.1 AK225632.1 AK296668.1 AK297615.1 AK298765.1 AK311366.1 BC003067.2 CR457259.1 
    U83981.1 

    19 DOTS entries:

    DT.100833736  DT.447968  DT.100758383  DT.91763099  DT.100840161  DT.91730447  DT.121500871  DT.100833742 
    DT.100833752  DT.95243347  DT.100833740  DT.100833754  DT.91763092  DT.91763097  DT.95145015  DT.95243307 
    DT.97770673  DT.121500887  DT.121500889 

    9 AceView cDNA sequences:

    CR606069 CR591206 CR623507 BC003067 CR620407 U83981 CR457259 AK001361 
    NM_014330 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R15A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCGGACCC
    PPP1R15A Expression
    About this image


    PPP1R15A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PPP1R15A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R15A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631593
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP1R15A: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Unfolded Protein Response in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PPP1R15A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R15A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R15A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r15a1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 66.77(n)1
    56.53(a)1
      7 (29.34 cM)5
    178721  NM_008654.21  NP_032680.11 
     455229165 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp1r15a6
    protein phosphatase 1, regulatory subunit 15A
    24(a)
    1 ↔ 1
    7(75191966-75197308) ENSDARG00000069135


    ENSEMBL Gene Tree for PPP1R15A (if available)
    TreeFam Gene Tree for PPP1R15A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R15A (see all 262)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442778041,2
    --49374011(+) AGGCCA/GAGGCG 1 -- us2k10--------
    rs129756491,2
    A--49374054(+) cctggC/Ttaaca 1 -- us2k10--------
    rs1408595701,2
    --49374074(+) ACCCCA/GTCTCT 1 -- us2k10--------
    rs5400391,2
    C,F,A--49374081(-) tcttaA/Gtagag 1 -- us2k14Minor allele frequency- G:0.29NA WA CSA 7
    rs8376111,2
    C,F,A--49374108(-) accacA/Gcccgg 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1846220241,2
    --49374109(+) CGGGCA/GTGGTG 1 -- us2k10--------
    rs1884986031,2
    --49374120(+) GTGGGC/TACCTG 1 -- us2k10--------
    rs8376101,2
    C,F,A--49374121(-) acaggC/Tgccca 1 -- us2k13Minor allele frequency- T:0.40NA CSA 5
    rs711790581,2
    C--49374248(-) AGGTCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1814045081,2
    --49374314(+) AAATAC/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP1R15A (49375649 - 49379319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PPP1R15A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833855CNV Loss17160897
    nsv833856CNV Loss17160897
    nsv912245CNV Loss21882294
    nsv470148CNV Gain18288195
    dgv3969n71CNV Gain21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611048    OMIM disorders: --

    Selected diseases for PPP1R15A (see all 32):    
    About MalaCards
    malignant pleural mesothelioma    tuberous sclerosis complex    herpes simplex    malignant mesothelioma
    tuberous sclerosis    squamous cell carcinoma of the head and neck    fatty liver disease    ischemia
    leiomyoma    thyroid cancer    colon adenocarcinoma    liver disease
    tonsillitis    cerebritis    osteosarcoma    neuroblastoma
    thyroiditis    cholangiocarcinoma    squamous cell carcinoma    pancreatic cancer


    PPP1R15A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PPP1R15A gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 51.7 4 12016208 (1), 12813455 (1), 11564868 (1), 16294031 (1)
    pleural malignant mesothelioma 34.4 1 16294031 (1)
    herpes 22.3 1 15059970 (1)
    nevi 21.3 1 10459500 (1)
    tumors 13.7 5 16138120 (2), 15059970 (1), 15674324 (1)
    cancer 12.7 4 19276161 (1), 15059970 (1), 15270080 (1)
    cerebral ischemia 9.28 1 11456315 (1)
    cardiac arrest 6.74 4 15541008 (3), 16337513 (1)
    leukemia 0 2 12016208 (1), 17548474 (1)
    ischemia 0 1 17584115 (1)

    Genetic Association Database (GAD): PPP1R15A
    Human Genome Epidemiology (HuGE) Navigator: PPP1R15A (2 documents)

    Export disorders for PPP1R15A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R15A gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with PPP1R15A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. (PubMed id 9153226)1, 2, 3, 9 Hollander M.C.... Fornace A.J. Jr. (J. Biol. Chem. 1997)
    2. The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34- bound protein phosphatase-1 activity. (PubMed id 12016208)1, 2, 9 Wu D.Y.... Schubach W.H. (J. Biol. Chem. 2002)
    3. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PubMed id 12724406)1, 2, 9 Hung W.J.... Wu D.Y. (Mol. Cell. Biol. 2003)
    4. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. (PubMed id 12556489)1, 2, 9 Brush M.H.... Shenolikar S. (Mol. Cell. Biol. 2003)
    5. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PubMed id 11564868)1, 2, 9 Connor J.H.... Shenolikar S. (Mol. Cell. Biol. 2001)
    6. Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins. (PubMed id 10490642)1, 2, 9 Adler H.T.... Tkachuk D.C. (Mol. Cell. Biol. 1999)
    7. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. (PubMed id 14718519)1, 2, 9 Shi W.... Cao X. (J. Cell Biol. 2004)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. (PubMed id 11517336)1, 2 Grishin A.V.... Corey S.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23645 HGNC: 14375 AceView: PPP1R15A Ensembl:ENSG00000087074 euGenes: HUgn23645
    ECgene: PPP1R15A Kegg: 23645 H-InvDB: PPP1R15A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP1R15A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R15A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP1R15A gene:
    Search GeneIP for patents involving PPP1R15A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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