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Aliases for PPP1R15A Gene

Aliases for PPP1R15A Gene

  • Protein Phosphatase 1, Regulatory Subunit 15A 2 3
  • Myeloid Differentiation Primary Response Protein MyD116 Homolog 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A 2 3
  • Growth Arrest And DNA Damage-Inducible Protein GADD34 3 4
  • Growth Arrest And DNA-Damage-Inducible 34 2 3
  • GADD34 3 4

External Ids for PPP1R15A Gene

Previous GeneCards Identifiers for PPP1R15A Gene

  • GC19P050033
  • GC19P049743
  • GC19P054051
  • GC19P054067
  • GC19P049375
  • GC19P045752

Summaries for PPP1R15A Gene

Entrez Gene Summary for PPP1R15A Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1R15A Gene

PPP1R15A (Protein Phosphatase 1, Regulatory Subunit 15A) is a Protein Coding gene. Diseases associated with PPP1R15A include malignant pleural mesothelioma. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein kinase binding and protein phosphatase type 1 regulator activity.

UniProtKB/Swiss-Prot for PPP1R15A Gene

  • Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on Ser-15.

Gene Wiki entry for PPP1R15A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R15A Gene

Genomics for PPP1R15A Gene

Regulatory Elements for PPP1R15A Gene

Genomic Location for PPP1R15A Gene

Chromosome:
19
Start:
48,872,392 bp from pter
End:
48,876,062 bp from pter
Size:
3,671 bases
Orientation:
Plus strand

Genomic View for PPP1R15A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R15A Gene

Proteins for PPP1R15A Gene

  • Protein details for PPP1R15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75807-PR15A_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 15A
    Protein Accession:
    O75807
    Secondary Accessions:
    • B4DKQ3
    • Q6IA96
    • Q9NVU6

    Protein attributes for PPP1R15A Gene

    Size:
    674 amino acids
    Molecular mass:
    73478 Da
    Quaternary structure:
    • Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.
    Miscellaneous:
    • The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress

    Three dimensional structures from OCA and Proteopedia for PPP1R15A Gene

    Alternative splice isoforms for PPP1R15A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R15A Gene

Proteomics data for PPP1R15A Gene at MOPED

Post-translational modifications for PPP1R15A Gene

  • Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2.
  • Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R15A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPP1R15A Gene

Domains & Families for PPP1R15A Gene

Gene Families for PPP1R15A Gene

Protein Domains for PPP1R15A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75807

UniProtKB/Swiss-Prot:

PR15A_HUMAN :
  • Belongs to the PPP1R15 family.
Family:
  • Belongs to the PPP1R15 family.
genes like me logo Genes that share domains with PPP1R15A: view

Function for PPP1R15A Gene

Molecular function for PPP1R15A Gene

UniProtKB/Swiss-Prot Function:
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on Ser-15.
UniProtKB/Swiss-Prot Induction:
By methyl methanesulfonate and ionizing irradiation. By IL24/interleukin-24 in melanoma cells; which induces apoptosis.

Gene Ontology (GO) - Molecular Function for PPP1R15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11564868
GO:0008157 protein phosphatase 1 binding IPI 12556489
GO:0008599 protein phosphatase type 1 regulator activity IC 11564868
GO:0019888 protein phosphatase regulator activity --
GO:0019901 protein kinase binding IPI 11517336
genes like me logo Genes that share ontologies with PPP1R15A: view
genes like me logo Genes that share phenotypes with PPP1R15A: view

Animal Models for PPP1R15A Gene

MGI Knock Outs for PPP1R15A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R15A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PPP1R15A Gene

Localization for PPP1R15A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R15A Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269 PubMed:21518769}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R15A Gene COMPARTMENTS Subcellular localization image for PPP1R15A gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 4
nucleus 1

Gene Ontology (GO) - Cellular Components for PPP1R15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IDA 11564868
GO:0005737 cytoplasm IDA 21518769
GO:0005739 mitochondrion IDA 21518769
GO:0005741 mitochondrial outer membrane IEA --
GO:0005783 endoplasmic reticulum IDA 12556489
genes like me logo Genes that share ontologies with PPP1R15A: view

Pathways & Interactions for PPP1R15A Gene

genes like me logo Genes that share pathways with PPP1R15A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PPP1R15A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP1R15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 9153226
GO:0006974 cellular response to DNA damage stimulus TAS 9153226
GO:0007050 cell cycle arrest TAS 9153226
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0010628 positive regulation of gene expression IMP 14635196
genes like me logo Genes that share ontologies with PPP1R15A: view

Drugs & Compounds for PPP1R15A Gene

(7) Drugs for PPP1R15A Gene - From: NovoSeek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
okadaic acid Experimental Pharma 0
Sephin1 Pharma Selective PPP1R15A inhibitor 0
methionine Nutra 70

(7) Additional Compounds for PPP1R15A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
lactate
Methylmethanesulfonate
O6-Benzylguanine
peroxynitrite
  • Peroxonitrite
  • (-)Oxoperoxonitrate
  • (1-)oxidoperoxidonitrate
  • Azoperoxoite
  • Pernitrite
19059-14-4
Thapsigargin
67526-95-8
genes like me logo Genes that share compounds with PPP1R15A: view

Transcripts for PPP1R15A Gene

mRNA/cDNA for PPP1R15A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R15A Gene

Protein phosphatase 1, regulatory subunit 15A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R15A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R15A Gene

No ASD Table

Relevant External Links for PPP1R15A Gene

GeneLoc Exon Structure for
PPP1R15A
ECgene alternative splicing isoforms for
PPP1R15A

Expression for PPP1R15A Gene

mRNA expression in normal human tissues for PPP1R15A Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R15A Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for PPP1R15A Gene

This gene is overexpressed in Retina (41.0) and Testis (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R15A Gene



SOURCE GeneReport for Unigene cluster for PPP1R15A Gene Hs.631593

genes like me logo Genes that share expression patterns with PPP1R15A: view

Protein tissue co-expression partners for PPP1R15A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PPP1R15A Gene

Orthologs for PPP1R15A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R15A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R15A 35
  • 74.81 (n)
  • 62.38 (a)
PPP1R15A 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r15a 35
  • 66.77 (n)
  • 56.53 (a)
Ppp1r15a 16
Ppp1r15a 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R15A 35
  • 99.06 (n)
  • 98.07 (a)
PPP1R15A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R15A 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R15A 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppp1r15a 36
  • 24 (a)
OneToOne
Species with no ortholog for PPP1R15A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R15A Gene

ENSEMBL:
Gene Tree for PPP1R15A (if available)
TreeFam:
Gene Tree for PPP1R15A (if available)

Paralogs for PPP1R15A Gene

No data available for Paralogs for PPP1R15A Gene

Variants for PPP1R15A Gene

Sequence variations from dbSNP and Humsavar for PPP1R15A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs524 -- 48,875,910(-) GGTGT(A/G)GCCAC reference, synonymous-codon
rs527 -- 48,875,925(-) GCAGA(C/G)GAGCG synonymous-codon, reference
rs500079 - 48,875,737(-) CTGGG(A/C/G/T)GATGC reference, missense
rs540039 -- 48,870,824(-) tctta(A/G)tagag upstream-variant-2KB
rs556052 - 48,874,179(-) CAAAG(C/G)CTTGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PPP1R15A Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833855 CNV Loss 17160897
nsv912245 CNV Loss 21882294
dgv3969n71 CNV Gain 21882294
nsv833856 CNV Loss 17160897
nsv470148 CNV Gain 18288195

Variation tolerance for PPP1R15A Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.66; 98.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R15A Gene

HapMap Linkage Disequilibrium report
PPP1R15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R15A Gene

Disorders for PPP1R15A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R15A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
- elite association

Relevant External Links for PPP1R15A

Genetic Association Database (GAD)
PPP1R15A
Human Genome Epidemiology (HuGE) Navigator
PPP1R15A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R15A
genes like me logo Genes that share disorders with PPP1R15A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R15A Gene

Publications for PPP1R15A Gene

  1. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. (PMID: 9153226) Hollander M.C. … Fornace A.J. Jr. (J. Biol. Chem. 1997) 2 23 67
  2. Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells. (PMID: 20022965) Armstrong J.L. … Redfern C.P. (J. Biol. Chem. 2010) 23 67
  3. Selenium decreases thyroid cancer cell growth by increasing expression of GADD153 and GADD34. (PMID: 20043261) Kato M.A. … Fahey T.J. (Nutr Cancer 2010) 23 67
  4. Cell-free protein synthesis systems with extracts from cultured human cells. (PMID: 20204847) Mikami S. … Imataka H. (Methods Mol. Biol. 2010) 23 67
  5. Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. (PMID: 19148492) Gazitt Y. … Freeman J. (Int. J. Oncol. 2009) 23 67

Products for PPP1R15A Gene

Sources for PPP1R15A Gene

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