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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R15A Gene

protein-coding   GIFtS: 56
GCID: GC19P049375

protein phosphatase 1, regulatory subunit 15A

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 15A...)
 Explore 34 diseases affiliated with
PPP1R15A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPP1R15A    

Aliases
for PPP1R15A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase 1, Regulatory Subunit 15A1 2     Myeloid Differentiation Primary Response Protein MyD116 Homolog2 3
GADD341 2 3 5     Growth Arrest And DNA-Damage-Inducible 342
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A1 2     Protein Phosphatase 1 Regulatory Subunit 15A2
Growth Arrest And DNA Damage-Inducible Protein GADD342 3     

External Ids:    HGNC: 143751   Entrez Gene: 236452   Ensembl: ENSG000000870747   OMIM: 6110485   UniProtKB: O758073   

Export aliases for PPP1R15A gene to outside databases

Previous GC identifers: GC19P050033 GC19P049743 GC19P054051 GC19P054067 GC19P045752


Summaries
for PPP1R15A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPP1R15A:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest
conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain
cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing
radiation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807
Function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor
eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and
facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting
dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'

Gene Wiki entry for PPP1R15A


Genomic Views
for PPP1R15A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R15A gene promoter:
         Sp1   AP-1   ATF-2   IRF-1   CREB   deltaCREB   IRF-7A   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1R15A promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R15A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R15A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.2

PPP1R15A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R15A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049375:  view genomic region     (about GC identifiers)

Start:
 49,375,649 bp from pter      End:
 49,379,319 bp from pter
Size:
 3,671 bases      Orientation:
 plus strand

Proteins
for PPP1R15A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 15A  
Size: 674 amino acids; 73478 Da
Subunit: Interacts with PCNA (By similarity). Interacts with LYN and MLL. Interacts with PP1, PPP1R1A and SMARCB1.
Interacts with SMAD7. Interacts with BAG1
Subcellular location: Endoplasmic reticulum
Miscellaneous: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by
Salubrinal, a drug that protects cells from endoplasmic reticulum stress
Secondary accessions: Q6IA96 Q9NVU6

Explore the universe of human proteins at neXtProt for PPP1R15A: NX_O75807

Post-translational modifications:

  • Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75807

    • PPP1R15A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055145.3  
    ENSEMBL proteins: 
     ENSP00000200453  
    Reactome Protein details: O75807
    Human Recombinant Protein Products: 
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    Uscn Proteins for PPP1R15A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol TAS--


    PPP1R15A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PPP1R15A

    Protein Domains /
    Families
    for PPP1R15A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPP1R15A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019523 Prot_Pase1_reg-su15A/B_C

    Graphical View of Domain Structure for InterPro Entry O75807

    ProtoNet protein and cluster: O75807

    UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807
    Similarity: Belongs to the PPP1R15 family


    Function
    for PPP1R15A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PR15A_HUMAN, O75807
    Function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor
    eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and
    facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting
    dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'
    Induction: By methyl methanesulfonate and ionizing irradiation. By IL24/interleukin-24 in melanoma cells; which induces
    apoptosis

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PPP1R15A:
    hsa-miR-1283
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PPP1R15A

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    PPP1R15A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PPP1R15A:
     Decreased melanin production 

    Animal Models:
         Mouse knock-outs for PPP1R15A: Ppp1r15atm1.1Ajf Ppp1r15atm1Kii Ppp1r15atm1Dron
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppp1r15a):
     cellular  growth/size  hematopoietic system  immune system  mortality/aging 
     normal 

    PPP1R15A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPP1R15A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    2Erythropoietin Pathway
    		Erythropoietin Pathway1.00
    		Insulin Receptor Pathway0.37
    		Beta-Adrenergic Signaling0.37
    		CDK5 Pathway0.21
    3TGF-beta receptor signaling activates SMADs
    		TGF-beta receptor signaling activates SMADs1.00
    		Downregulation of TGF-beta receptor signaling0.90
    4Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    5TGF-beta receptor signaling
    		TGF-beta receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R15A (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    2 BioSystems Pathways for PPP1R15A 
        TGF-beta receptor signaling
    BMP receptor signaling

    4        Reactome Pathways for PPP1R15A
        Signaling by TGF-beta Receptor Complex
    TGF-beta receptor signaling activates SMADs
    Signal Transduction
    Downregulation of TGF-beta receptor signaling


    1         Kegg Pathway  (Kegg details for PPP1R15A):
        Protein processing in endoplasmic reticulum


    PPP1R15A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R15A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for PPP1R15A (O758071, 2, 3 ENSP000002004534) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3, ENSP000003260314MINT-62196 I2D: score=4 STRING: ENSP00000326031
    PPP1R1AQ135221, 3, ENSP000002579054EBI-714746,EBI-1568511 I2D: score=2 STRING: ENSP00000257905
    ZNF512BQ96KM62, 3MINT-60788 I2D: score=2 
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    POU3F3P202642, 3, ENSP000003550014MINT-63546 I2D: score=4 STRING: ENSP00000355001
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0006915apoptotic process IEA--
    GO:0006974response to DNA damage stimulus TAS9153226
    GO:0007050cell cycle arrest TAS9153226
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--


    PPP1R15A for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPP1R15A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP1R15A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R15A
    10/13 Novoseek chemical compound relationships for PPP1R15A gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    o6-benzylguanine 56.8 6 16325149 (3), 16391370 (2)
    thapsigargin 46.3 4 18266951 (1), 20022965 (1), 12556489 (1), 19302589 (1)
    okadaic acid 45.3 2 19776135 (1), 12556489 (1)
    methylmethanesulfonate 41 1 11104688 (1)
    tunicamycin 36.7 1 12556489 (1)
    peroxynitrite 20.9 1 11163539 (1)
    cisplatin 15.9 12 16325149 (6), 16294031 (2)
    threonine 15.4 3 11104688 (1), 12840028 (1), 11564868 (1)
    carboplatin 15.3 1 15031599 (1)
    lactate 6.1 3 16039175 (1), 17080237 (1), 16294031 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP1R15A / PR15A 

    Transcripts
    for PPP1R15A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPP1R15A gene: 
    NM_014330.3  

    Unigene Cluster for PPP1R15A:

    Protein phosphatase 1, regulatory subunit 15A
    Hs.631593  [show with all ESTs]
    Unigene Representative Sequence: NM_014330
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000200453(uc002pky.4)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PPP1R15A:
    hsa-miR-1283
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK001361.1 AK225632.1 AK296668.1 AK297615.1 AK298765.1 AK311366.1 BC003067.2 CR457259.1 
    U83981.1 

    19 DOTS entries:

    DT.100833736  DT.447968  DT.100758383  DT.91763099  DT.100840161  DT.91730447  DT.121500871  DT.100833742 
    DT.100833752  DT.95243347  DT.100833740  DT.100833754  DT.91763092  DT.91763097  DT.95145015  DT.95243307 
    DT.97770673  DT.121500887  DT.121500889 

    9 AceView cDNA sequences:

    BC003067 CR591206 CR606069 CR623507 U83981 CR620407 AK001361 NM_014330 
    CR457259 

    GeneLoc Exon Structure


    Expression
    for PPP1R15A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R15A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCGGACCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPP1R15A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPP1R15A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R15A

    SOURCE GeneReport for Unigene cluster: Hs.631593
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPP1R15A: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Unfolded Protein Response in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for PPP1R15A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R15A gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppp1r15a1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 66.5(n)1
    52.57(a)1    		   7 (29.34 cM)5
    178721  NM_008654.21  NP_032680.11 
     455229165 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1621266
    		 zgc:162126
    		 30(a)
    		 1 ↔ 1
    		 7(75191966-75197308)


    ENSEMBL Gene Tree for PPP1R15A (if available)
    TreeFam Gene Tree for PPP1R15A (if available) 

    Paralogs
    for PPP1R15A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PPP1R15A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/196 NCBI SNPs in PPP1R15A are shown (see all 196)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1920144481,2
    		--49373695(+) GAGGCA/GGAGGT 3 -- us2k10--------
    rs1396517511,2
    		C--49373809(+) AAAAG-/AAAAAA 3 -- us2k10--------
    rs1442778041,2
    		--49374011(+) AGGCCA/GAGGCG 1 -- us2k10--------
    rs129756491,2
    		A--49374054(+) cctggC/Ttaaca 1 -- us2k10--------
    rs1408595701,2
    		--49374074(+) ACCCCA/GTCTCT 1 -- us2k10--------
    rs5400391,2
    		C,F,A,--49374081(-) tcttaA/Gtagag 1 -- us2k14Minor allele frequency- G:0.29NA WA CSA 7
    rs8376111,2
    		C,A,--49374108(-) accacA/Gcccgg 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1846220241,2
    		--49374109(+) CGGGCA/GTGGTG 1 -- us2k10--------
    rs1884986031,2
    		--49374120(+) GTGGGC/TACCTG 1 -- us2k10--------
    rs8376101,2
    		C,F,A,--49374121(-) ACAGGC/TGCCCA 1 -- us2k13Minor allele frequency- T:0.40NA CSA 5

    HapMap Linkage Disequilibrium report for PPP1R15A (49375649 - 49379319 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PPP1R15A
         3 CNVs: 5108 5107 32261

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    Disorders / Diseases
    for PPP1R15A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPP1R15A for disorders           About GeneDecksing

    OMIM gene information: 611048    OMIM disorders: --

    20/34 diseases for PPP1R15A (see all 34):    About MalaCards
    adenomatous polyposis coli    malignant pleural mesothelioma    malignant mesothelioma    herpes simplex
    squamous cell carcinoma of the head and neck    fatty liver disease    squamous cell carcinoma    tuberous sclerosis
    neuroectodermal tumors    liver disease    polyposis    ischemia
    colon adenocarcinoma    leiomyoma    hepatocellular carcinoma    cerebritis
    colon cancer    thyroid cancer    ovarian cancer    carcinoma

    10/11 Novoseek disease relationships for PPP1R15A gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 51.7 4 12016208 (1), 12813455 (1), 11564868 (1), 16294031 (1)
    pleural malignant mesothelioma 34.4 1 16294031 (1)
    herpes 22.3 1 15059970 (1)
    nevi 21.3 1 10459500 (1)
    tumors 13.7 5 16138120 (2), 15059970 (1), 15674324 (1)
    cancer 12.7 4 19276161 (1), 15059970 (1), 15270080 (1)
    cerebral ischemia 9.28 1 11456315 (1)
    cardiac arrest 6.74 4 15541008 (3), 16337513 (1)
    leukemia 0 2 12016208 (1), 17548474 (1)
    ischemia 0 1 17584115 (1)

    Human Genome Epidemiology (HuGE) Navigator: PPP1R15A (2 documents)

    Export disorders for PPP1R15A gene to outside databases

    Publications
    for PPP1R15A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R15A gene, integrated from 9 sources (see all 99):
    (articles sorted by number of sources associating them with PPP1R15A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. (PubMed id 9153226)1, 2, 3, 9 Hollander M.C.... Fornace A.J. Jr. (1997)
    2. The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34- bound protein phosphatase-1 activity. (PubMed id 12016208)1, 2, 9 Wu D.Y.... Schubach W.H. (2002)
    3. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PubMed id 12724406)1, 2, 9 Hung W.J.... Wu D.Y. (2003)
    4. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. (PubMed id 12556489)1, 2, 9 Brush M.H.... Shenolikar S. (2003)
    5. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PubMed id 11564868)1, 2, 9 Connor J.H.... Shenolikar S. (2001)
    6. Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins. (PubMed id 10490642)1, 2, 9 Adler H.T.... Tkachuk D.C. (1999)
    7. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. (PubMed id 14718519)1, 2, 9 Shi W.... Cao X. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. (PubMed id 11517336)1, 2 Grishin A.V.... Corey S.J. (2001)
    10. Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas. (PubMed id 9413226)1, 3 Korabiowska M....Schauer A. (1997)

    External Searches for PPP1R15A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPP1R15A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23645 HGNC: 14375 AceView: PPP1R15A Ensembl:ENSG00000087074 euGenes: HUgn23645
    ECgene: PPP1R15A Kegg: 23645 H-InvDB: PPP1R15A

    Other Databases showing PPP1R15A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPP1R15A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R15A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R15A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PPP1R15A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPP1R15A gene:
    Search GeneIP for patents involving PPP1R15A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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