Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R14C Gene

Aliases for PPP1R14C Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C 2 3
  • Serologically Defined Breast Cancer Antigen NY-BR-81 3 4
  • PKC-Potentiated PP1 Inhibitory Protein 3 4
  • Kinase C-Enhanced PP1 Inhibitor 2 3
  • Kinase-Enhanced PP1 Inhibitor 3 4
  • KEPI 3 4
  • CPI17-Like 3
  • NY-BR-81 3

External Ids for PPP1R14C Gene

Previous GeneCards Identifiers for PPP1R14C Gene

  • GC06P150025
  • GC06P150359
  • GC06P150495
  • GC06P150556
  • GC06P150505
  • GC06P150464
  • GC06P148029

Summaries for PPP1R14C Gene

Entrez Gene Summary for PPP1R14C Gene

  • The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14C Gene

PPP1R14C (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot for PPP1R14C Gene

  • Inhibitor of the PP1 regulatory subunit PPP1CA.

Gene Wiki entry for PPP1R14C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14C Gene

Genomics for PPP1R14C Gene

Regulatory Elements for PPP1R14C Gene

Enhancers for PPP1R14C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R14C on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R14C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R14C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R14C Gene

150,143,052 bp from pter
150,250,392 bp from pter
107,341 bases
Plus strand

Genomic View for PPP1R14C Gene

Genes around PPP1R14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14C Gene

Proteins for PPP1R14C Gene

  • Protein details for PPP1R14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Protein Accession:
    Secondary Accessions:
    • Q5VY83
    • Q96BB1
    • Q9H277

    Protein attributes for PPP1R14C Gene

    165 amino acids
    Molecular mass:
    17843 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG48264.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PPP1R14C Gene

Proteomics data for PPP1R14C Gene at MOPED

Post-translational modifications for PPP1R14C Gene

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14C Gene

Domains & Families for PPP1R14C Gene

Gene Families for PPP1R14C Gene

Protein Domains for PPP1R14C Gene


Suggested Antigen Peptide Sequences for PPP1R14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PP1 inhibitor family.
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14C: view

Function for PPP1R14C Gene

Molecular function for PPP1R14C Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the PP1 regulatory subunit PPP1CA.
genes like me logo Genes that share phenotypes with PPP1R14C: view

Animal Models for PPP1R14C Gene

MGI Knock Outs for PPP1R14C:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R14C Gene

Localization for PPP1R14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14C Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for PPP1R14C Gene COMPARTMENTS Subcellular localization image for PPP1R14C gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PPP1R14C Gene

Pathways & Interactions for PPP1R14C Gene

SuperPathways for PPP1R14C Gene

No Data Available

Interacting Proteins for PPP1R14C Gene

SIGNOR curated interactions for PPP1R14C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA,IBA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Pathways by source for PPP1R14C Gene

Drugs & Compounds for PPP1R14C Gene

(1) Drugs for PPP1R14C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R14C: view

Transcripts for PPP1R14C Gene

mRNA/cDNA for PPP1R14C Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R14C Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14C Gene

No ASD Table

Relevant External Links for PPP1R14C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R14C Gene

mRNA expression in normal human tissues for PPP1R14C Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R14C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.2), Heart - Left Ventricle (x6.5), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for PPP1R14C Gene

This gene is overexpressed in Adipocyte (37.9), Fetal heart (14.2), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R14C Gene

SOURCE GeneReport for Unigene cluster for PPP1R14C Gene Hs.486798

mRNA Expression by UniProt/SwissProt for PPP1R14C Gene

Tissue specificity: Detected in breast cancer.
genes like me logo Genes that share expression patterns with PPP1R14C: view

Protein tissue co-expression partners for PPP1R14C Gene

Primer Products

Orthologs for PPP1R14C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC783497 35
  • 88.28 (n)
  • 90.91 (a)
PPP1R14C 36
  • 92 (a)
(Canis familiaris)
Mammalia PPP1R14C 35
  • 94.02 (n)
  • 93.1 (a)
-- 36
  • 60 (a)
(Mus musculus)
Mammalia Ppp1r14c 35
  • 86.59 (n)
  • 89.02 (a)
Ppp1r14c 16
Ppp1r14c 36
  • 91 (a)
(Pan troglodytes)
Mammalia PPP1R14C 35
  • 99.39 (n)
  • 98.79 (a)
PPP1R14C 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ppp1r14c 35
  • 86.59 (n)
  • 89.63 (a)
(Monodelphis domestica)
Mammalia PPP1R14C 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R14C 36
  • 80 (a)
(Gallus gallus)
Aves PPP1R14C 36
  • 78 (a)
(Anolis carolinensis)
Reptilia PPP1R14C 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14c 35
  • 82.46 (n)
  • 86.32 (a)
Str.11 35
(Danio rerio)
Actinopterygii ppp1r14c 35
  • 75.89 (n)
  • 79.79 (a)
ppp1r14c 36
  • 69 (a)
ppp1r14c 36
  • 69 (a)
Species with no ortholog for PPP1R14C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14C Gene

Gene Tree for PPP1R14C (if available)
Gene Tree for PPP1R14C (if available)

Paralogs for PPP1R14C Gene

Paralogs for PPP1R14C Gene

(4) SIMAP similar genes for PPP1R14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPP1R14C: view

Variants for PPP1R14C Gene

Sequence variations from dbSNP and Humsavar for PPP1R14C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2297672 - 150,143,220(+) GCGAG(A/G)CGGCC reference, missense
rs1040661 -- 150,237,574(-) TCATC(A/G)TTATC intron-variant
rs1044672 -- 150,249,216(+) TTGTA(C/T)ATTTG utr-variant-3-prime
rs1086202 -- 150,243,096(+) gttct(C/T)cccaa intron-variant
rs1086203 -- 150,243,398(+) gtctt(A/G)aactc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14C Gene

Variant ID Type Subtype PubMed ID
nsv886770 CNV Gain 21882294
nsv5536 CNV Insertion 18451855
esv1003519 CNV Insertion 20482838
esv2434869 CNV Insertion 19546169
nsv5537 CNV Insertion 18451855
nsv830843 CNV Gain+Loss 17160897
esv26363 CNV Gain 19812545
esv260018 OTHER Complex 20981092

Variation tolerance for PPP1R14C Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R14C Gene

Disorders for PPP1R14C Gene

Relevant External Links for PPP1R14C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14C Gene

Publications for PPP1R14C Gene

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PMID: 11812771) Liu Q.-R. … Uhl G. (J. Biol. Chem. 2002) 3 4 23 67
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PMID: 23284291) Hancock D.B. … London S.J. (PLoS Genet. 2012) 3
  5. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3

Products for PPP1R14C Gene

Sources for PPP1R14C Gene