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Aliases for PPP1R14C Gene

Aliases for PPP1R14C Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-81 3 4
  • PKC-Potentiated PP1 Inhibitory Protein 3 4
  • Kinase C-Enhanced PP1 Inhibitor 2 3
  • Kinase-Enhanced PP1 Inhibitor 3 4
  • KEPI 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C 2
  • Protein Phosphatase 1 Regulatory Subunit 14C 3
  • CPI17-Like 3
  • NY-BR-81 3

External Ids for PPP1R14C Gene

Previous GeneCards Identifiers for PPP1R14C Gene

  • GC06P150025
  • GC06P150359
  • GC06P150495
  • GC06P150556
  • GC06P150505
  • GC06P150464
  • GC06P148029

Summaries for PPP1R14C Gene

Entrez Gene Summary for PPP1R14C Gene

  • The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14C Gene

PPP1R14C (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot for PPP1R14C Gene

  • Inhibitor of the PP1 regulatory subunit PPP1CA.

Gene Wiki entry for PPP1R14C Gene

Additional gene information for PPP1R14C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14C Gene

Genomics for PPP1R14C Gene

Regulatory Elements for PPP1R14C Gene

Enhancers for PPP1R14C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H150200 1 ENCODE dbSUPER 20.8 +58.8 58830 2 BCOR PKNOX1 ESRRA ZMYM3 FOSL2 FOS SMARCA5 L3MBTL2 BHLHE40 MNT PPP1R14C ENSG00000238594 RNU4-7P IYD LOC105378054
GH06H150250 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +111.4 111357 7 PKNOX1 ATF1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GATA2 KLF7 FOS NUP43 PPIL4 ENSG00000231760 KATNA1 LATS1 ENSG00000238594 PPP1R14C RAET1G ULBP2 RAET1L
GH06H150266 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +127.3 127318 8 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF416 FOS SP3 LATS1 NUP43 PPIL4 KATNA1 ENSG00000233330 ENSG00000231760 RNU4-7P ENSG00000238594 RPS18P9 PPP1R14C
GH06H150176 1.7 VISTA FANTOM5 ENCODE dbSUPER 7.9 +34.0 33955 2 RFX1 KLF17 EBF1 NR3C1 ZIC2 GLIS1 SCRT2 ZSCAN5C HMBOX1 ZBTB33 PPP1R14C ENSG00000238594 LOC105378054
GH06H150071 1.1 Ensembl ENCODE 11 -70.8 -70752 0 HDGF PKNOX1 KLF17 GLIS2 ZNF366 SCRT2 RCOR1 KLF7 FOS SP3 ULBP3 PPP1R14C IYD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R14C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R14C Gene

Chromosome:
6
Start:
150,143,052 bp from pter
End:
150,250,392 bp from pter
Size:
107,341 bases
Orientation:
Plus strand

Genomic View for PPP1R14C Gene

Genes around PPP1R14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14C Gene

Proteins for PPP1R14C Gene

  • Protein details for PPP1R14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE6-PP14C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Protein Accession:
    Q8TAE6
    Secondary Accessions:
    • Q5VY83
    • Q96BB1
    • Q9H277

    Protein attributes for PPP1R14C Gene

    Size:
    165 amino acids
    Molecular mass:
    17843 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG48264.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PPP1R14C Gene

Post-translational modifications for PPP1R14C Gene

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14C Gene

Domains & Families for PPP1R14C Gene

Gene Families for PPP1R14C Gene

Protein Domains for PPP1R14C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAE6

UniProtKB/Swiss-Prot:

PP14C_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14C: view

Function for PPP1R14C Gene

Molecular function for PPP1R14C Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the PP1 regulatory subunit PPP1CA.

Phenotypes From GWAS Catalog for PPP1R14C Gene

Gene Ontology (GO) - Molecular Function for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004865 protein serine/threonine phosphatase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view
genes like me logo Genes that share phenotypes with PPP1R14C: view

Animal Models for PPP1R14C Gene

MGI Knock Outs for PPP1R14C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPP1R14C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R14C Gene

Localization for PPP1R14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14C Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14C gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14C Gene

Pathways & Interactions for PPP1R14C Gene

SuperPathways for PPP1R14C Gene

No Data Available

SIGNOR curated interactions for PPP1R14C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Pathways by source for PPP1R14C Gene

Drugs & Compounds for PPP1R14C Gene

(1) Drugs for PPP1R14C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R14C: view

Transcripts for PPP1R14C Gene

mRNA/cDNA for PPP1R14C Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R14C Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPP1R14C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14C Gene

No ASD Table

Relevant External Links for PPP1R14C Gene

GeneLoc Exon Structure for
PPP1R14C
ECgene alternative splicing isoforms for
PPP1R14C

Expression for PPP1R14C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R14C Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R14C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.2), Heart - Left Ventricle (x6.5), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for PPP1R14C Gene

This gene is overexpressed in Adipocyte (37.9), Fetal heart (14.2), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R14C Gene



Protein tissue co-expression partners for PPP1R14C Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R14C Gene:

PPP1R14C

SOURCE GeneReport for Unigene cluster for PPP1R14C Gene:

Hs.486798

mRNA Expression by UniProt/SwissProt for PPP1R14C Gene:

Q8TAE6-PP14C_HUMAN
Tissue specificity: Detected in breast cancer.

Evidence on tissue expression from TISSUES for PPP1R14C Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with PPP1R14C: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14C Gene

Orthologs for PPP1R14C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R14C 33 34
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia PPP1R14C 33
  • 94.02 (n)
-- 34
  • 60 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PPP1R14C 34
  • 92 (a)
OneToOne
LOC783497 33
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Ppp1r14c 33 16 34
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Ppp1r14c 33
  • 86.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R14C 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R14C 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1R14C 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R14C 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14c 33
  • 82.46 (n)
Str.11 33
zebrafish
(Danio rerio)
Actinopterygii LOC100330870 33
  • 75.89 (n)
ppp1r14c 34 34
  • 69 (a)
OneToMany
Species where no ortholog for PPP1R14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14C Gene

ENSEMBL:
Gene Tree for PPP1R14C (if available)
TreeFam:
Gene Tree for PPP1R14C (if available)

Paralogs for PPP1R14C Gene

Paralogs for PPP1R14C Gene

(4) SIMAP similar genes for PPP1R14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPP1R14C: view

Variants for PPP1R14C Gene

Sequence variations from dbSNP and Humsavar for PPP1R14C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000044510 -- 150,208,790(+) ACATA(A/C)TTCTG intron-variant
rs1000052024 -- 150,141,118(+) AGGCT(C/G)GGTGC upstream-variant-2KB
rs1000059672 -- 150,158,495(+) CATTT(C/G)AGTTA intron-variant
rs1000059921 -- 150,248,070(+) ACAAG(C/T)GTGTG intron-variant
rs1000123756 -- 150,165,135(+) CAGGA(G/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14C Gene

Variant ID Type Subtype PubMed ID
dgv1839e212 CNV loss 25503493
dgv1840e212 CNV loss 25503493
esv1003519 CNV insertion 20482838
esv2434869 CNV insertion 19546169
esv26363 CNV gain 19812545
esv3303044 CNV tandem duplication 20981092
esv3571450 CNV loss 25503493
esv3571462 CNV loss 25503493
esv3576235 CNV gain 25503493
esv3611228 CNV loss 21293372
esv3890963 CNV loss 25118596
nsv1026690 CNV gain 25217958
nsv1140712 CNV deletion 24896259
nsv1141828 CNV insertion 24896259
nsv1148196 CNV insertion 26484159
nsv1151745 CNV insertion 26484159
nsv477214 CNV novel sequence insertion 20440878
nsv5536 CNV insertion 18451855
nsv5537 CNV insertion 18451855
nsv604848 CNV gain 21841781
nsv830843 CNV gain+loss 17160897

Variation tolerance for PPP1R14C Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14C Gene

Disorders for PPP1R14C Gene

Relevant External Links for PPP1R14C

Genetic Association Database (GAD)
PPP1R14C
Human Genome Epidemiology (HuGE) Navigator
PPP1R14C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R14C

No disorders were found for PPP1R14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14C Gene

Publications for PPP1R14C Gene

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PMID: 11812771) Liu QR … Uhl GR (The Journal of biological chemistry 2002) 3 4 22 60
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 45 60
  3. SNCA variants are associated with increased risk for multiple system atrophy. (PMID: 19475667) Scholz SW … Gasser T (Annals of neurology 2009) 3 45 60
  4. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D … International Kawasaki Disease Genetics Consortium (PLoS genetics 2009) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for PPP1R14C Gene

Sources for PPP1R14C Gene

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