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PPP1R14C Gene

protein-coding   GIFtS: 52
GCID: GC06P150464

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C1 2     PKC-Potentiated PP1 Inhibitory Protein2 3
KEPI2 3 5     CPI17-like2
Kinase C-Enhanced PP1 Inhibitor1 2     NY-BR-812
Kinase-Enhanced PP1 Inhibitor2 3     Protein Phosphatase 1 Regulatory Subunit 14C2
Serologically Defined Breast Cancer Antigen NY-BR-812 3     

External Ids:    HGNC: 149521   Entrez Gene: 817062   Ensembl: ENSG000001987297   OMIM: 6132425   UniProtKB: Q8TAE63   

Export aliases for PPP1R14C gene to outside databases

Previous GC identifers: GC06P150025 GC06P150359 GC06P150495 GC06P150556 GC06P150505 GC06P148029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R14C Gene:
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities.
Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal
activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1
(Liu et al., 2002 (PubMed 11812771)).(supplied by OMIM, Feb 2010)

GeneCards Summary for PPP1R14C Gene:
PPP1R14C (protein phosphatase 1, regulatory (inhibitor) subunit 14C) is a protein-coding gene. Diseases associated with PPP1R14C include breast cancer, and multiple system atrophy. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14A.

UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
Function: Inhibitor of the PP1 regulatory subunit PPP1CA

Gene Wiki entry for PPP1R14C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R14C gene promoter:
         AML1a   NF-kappaB   Tal-1beta   LCR-F1   E47   RORalpha2   Nkx6-1   FOXO4   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R14C promoter sequence
   Search Chromatin IP Primers for PPP1R14C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R14C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3-q25.3   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q24.3-q25.3

PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R14C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150464:  view genomic region     (about GC identifiers)

Start:
150,464,188 bp from pter      End:
150,571,528 bp from pter
Size:
107,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 14C  
Size: 165 amino acids; 17843 Da
Sequence caution: Sequence=AAG48264.1; Type=Erroneous initiation;
Secondary accessions: Q5VY83 Q96BB1 Q9H277

Explore the universe of human proteins at neXtProt for PPP1R14C: NX_Q8TAE6

Explore proteomics data for PPP1R14C at MOPED

Post-translational modifications: 

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the
    phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory
    site appears to be Thr-731
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R14C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112211.1  
    ENSEMBL proteins: 
     ENSP00000355260  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR008025 PP1_inhibitor

    Graphical View of Domain Structure for InterPro Entry Q8TAE6

    ProtoNet protein and cluster: Q8TAE6

    UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
    Similarity: Belongs to the PP1 inhibitor family


    PPP1R14C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP14C_HUMAN, Q8TAE6
    Function: Inhibitor of the PP1 regulatory subunit PPP1CA

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004865protein serine/threonine phosphatase inhibitor activity IEA--
         
    PPP1R14C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP1R14C:
     Increased Erk phosphorylation   Upregulation of NF-kappaB path 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp1r14c):
     behavior/neurological  integument  mortality/aging 

    PPP1R14C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp1r14ctm1Uhl for PPP1R14C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1R14C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R14C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1R14C

    miRNA
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    miRTarBase miRNAs that target PPP1R14C:
    hsa-mir-29c-3p (MIRT020380), hsa-mir-340-5p (MIRT019567)

    Block miRNA regulation of human, mouse, rat PPP1R14C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1R14C (see all 20):
    hsa-miR-30c hsa-miR-3128 hsa-miR-100* hsa-miR-631 hsa-miR-300 hsa-miR-30d hsa-miR-3661 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R14C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1R14C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R14C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP14C_HUMAN, Q8TAE6: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    PPP1R14C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PPP1R14C: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP1R14C

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for PPP1R14C (Q8TAE63 ENSP000003552604) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAP25Q8TEE93I2D: score=1 
    ILKENSP000002994214STRING: ENSP00000299421
    SIRT3ENSP000003721914STRING: ENSP00000372191
    SIRT5ENSP000003685524STRING: ENSP00000368552
    HDAC6ENSP000003340614STRING: ENSP00000334061
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042325regulation of phosphorylation IEA--

    PPP1R14C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R14C (PP14C)

    1 Novoseek inferred chemical compound relationship for PPP1R14C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.4 4 11812771 (1)



    PPP1R14C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP1R14C gene: 
    NM_030949.2  

    Unigene Cluster for PPP1R14C:

    Protein phosphatase 1, regulatory (inhibitor) subunit 14C
    Hs.486798  [show with all ESTs]
    Unigene Representative Sequence: AF407165
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361131(uc003qnt.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPP1R14C (see all 20):
    hsa-miR-30c hsa-miR-3128 hsa-miR-100* hsa-miR-631 hsa-miR-300 hsa-miR-30d hsa-miR-3661 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R14C 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PPP1R14C (NM_030949)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP1R14C
      QuantiTect SYBR Green Assays in human, mouse, rat PPP1R14C
      QuantiFast Probe-based Assays in human, mouse, rat PPP1R14C

    Additional mRNA sequence: 

    AF308297.1 AF407165.2 AK092697.1 AK096272.1 BC015773.1 

    1 DOTS entry:

    DT.414582 

    Selected AceView cDNA sequences (see all 85):

    AF407165 AA741014 AA788675 AW182882 BM982254 AA670373 F10005 AA883629 
    CK819415 AI401474 CK819414 N44532 F12388 AW057524 AW613012 Z41626 
    AI242545 AW276309 NM_030949 BQ017225 CA411646 BM142095 AI081346 Z43025 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R14C expression in normal human tissues (normalized intensities)      PPP1R14C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPP1R14C Expression
    About this image


    PPP1R14C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Bone (Muscoskeletal System)
             Chondrocyte-like cells
     
     Cartilage (Muscoskeletal System)
             Chondrocyte-like cells
     
     Heart (Cardiovascular System)
    PPP1R14C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R14C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486798

    UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
    Tissue specificity: Detected in breast cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP1R14C: 
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R14C gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r14c1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 86.59(n)1
    89.02(a)1
      10 (2.06 cM)5
    761421  NM_133485.21  NP_597844.11 
     33661505 
    chicken
    (Gallus gallus)
    Aves PPP1R14C6
    protein phosphatase 1, regulatory (inhibitor) subu...
    78(a)
    1 ↔ 1
    3(47607407-47658949)
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R14C6
    protein phosphatase 1, regulatory (inhibitor) subu...
    84(a)
    1 ↔ 1
    GL343259.1(487267-492989)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.112 Transcribed sequence with weak similarity to protein more 82.9(n)    AL874588.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp1r14c1 protein phosphatase 1, regulatory (inhibitor) subunit more 75.89(n)
    79.79(a)
      568055  NM_001029963.1  NP_001025134.1 


    ENSEMBL Gene Tree for PPP1R14C (if available)
    TreeFam Gene Tree for PPP1R14C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R14C gene
    PPP1R14A2  PPP1R14D2  PPP1R14B2  
    4 SIMAP similar genes for PPP1R14C using alignment to 2 protein entries:     PP14C_HUMAN (see all proteins):
    PPP1R14B    LIMK2    PPP1R14A    PPP1R14D

    PPP1R14C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R14C (see all 2496)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166095251,2
    C,F--150462203(+) GTCATC/TGGTCT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1382143841,2
    --150462215(+) TAGGGA/GCAATC 1 -- us2k10--------
    rs1120598391,2
    C,F--150462537(+) CAGAGC/GTGGGC 1 -- us2k12Minor allele frequency- G:0.04NA 122
    rs1811200201,2
    --150462567(+) TGAAGC/TGCCAG 1 -- us2k10--------
    rs1869804491,2
    C--150462767(+) ACAAAC/TAAAAA 1 -- us2k10--------
    rs1142654301,2
    C,F--150462779(+) AGTTCA/GTGGCC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1917725671,2
    --150462837(+) GCGGGC/TGGATC 1 -- us2k10--------
    rs1164477821,2
    F--150462935(+) GAAAGC/TCTGTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1120242371,2
    C--150462986(+) AACCCA/C/TGAAGT 1 -- us2k11CSA 1
    rs1836171641,2
    --150462992(+) GAAGTC/GAGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP1R14C (150464188 - 150571528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PPP1R14C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5536CNV Insertion18451855
    nsv5537CNV Insertion18451855
    esv1003519CNV Insertion20482838
    esv2434869CNV Insertion19546169
    nsv886770CNV Gain21882294
    esv26363CNV Gain19812545
    nsv830843CNV Gain+Loss17160897
    esv260018OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613242    OMIM disorders: --

    8 diseases for PPP1R14C:    About MalaCards
    breast cancer    multiple system atrophy    gout    measles
    kawasaki disease    pulmonary function    neuronitis    cerebritis


    PPP1R14C for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP1R14C
    Human Genome Epidemiology (HuGE) Navigator: PPP1R14C (2 documents)

    Export disorders for PPP1R14C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R14C gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PPP1R14C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PubMed id 11812771)1, 2, 9 Liu Q.-R.... Uhl G. (J. Biol. Chem. 2002)
    2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    3. SNCA variants are associated with increased risk for multiple system atrophy. (PubMed id 19475667)1, 4 Scholz S.W....Gasser T. (Ann. Neurol. 2009)
    4. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PubMed id 19132087)1, 4 Burgner D....Hibberd M.L. (PLoS Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PubMed id 11948623)1, 3 Ceulemans H.... Bollen M. (Bioessays 2002)
    8. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2 Scanlan M.J.... Old L.J. (Cancer Immun. 2001)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81706 HGNC: 14952 AceView: PPP1R14C Ensembl:ENSG00000198729 euGenes: HUgn81706
    ECgene: PPP1R14C H-InvDB: PPP1R14C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R14C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R14C gene:
    Search GeneIP for patents involving PPP1R14C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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