Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R14C Gene

protein-coding   GIFtS: 50
GCID: GC06P150464

protein phosphatase 1, regulatory (inhibitor) subunit 14C

 Explore 7 diseases affiliated with
PPP1R14C via our new
 Human Malady Compendium 
Biological research products
for PPP1R14C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C1 2     Serologically Defined Breast Cancer Antigen NY-BR-812 3
KEPI1 2 3 5     PKC-Potentiated PP1 Inhibitory Protein2 3
CPI17-Like1     Kinase C-Enhanced PP1 Inhibitor2
NY-BR-811 2     Protein Phosphatase 1 Regulatory Subunit 14C2
Kinase-Enhanced PP1 Inhibitor2 3     

External Ids:    HGNC: 149521   Entrez Gene: 817062   Ensembl: ENSG000001987297   OMIM: 6132425   UniProtKB: Q8TAE63   

Export aliases for PPP1R14C gene to outside databases

Previous GC identifers: GC06P150025 GC06P150359 GC06P150495 GC06P150556 GC06P150505 GC06P148029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R14C:
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein
phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein
synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002
(PubMed 11812771)).(supplied by OMIM, Feb 2010)

UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
Function: Inhibitor of the PP1 regulatory subunit PPP1CA

Gene Wiki entry for PPP1R14C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R14C gene promoter:
         AML1a   NF-kappaB   Tal-1beta   LCR-F1   E47   RORalpha2   Nkx6-1   FOXO4   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R14C promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R14C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R14C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3-q25.3   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q24.3-q25.3

PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R14C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150464:  view genomic region     (about GC identifiers)

Start:
150,464,188 bp from pter      End:
150,571,528 bp from pter
Size:
107,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 14C  
Size: 165 amino acids; 17843 Da
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=AAG48264.1; Type=Erroneous initiation;
Secondary accessions: Q5VY83 Q96BB1 Q9H277

Explore the universe of human proteins at neXtProt for PPP1R14C: NX_Q8TAE6

Post-translational modifications:

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the
  • phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site
    appears to be Thr-731
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TAE6

  • PPP1R14C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112211.1  
    ENSEMBL proteins: 
     ENSP00000355260  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PPP1R14C 
    GenScript Custom Purified and Recombinant Proteins Services for PPP1R14C
    Novus Biologicals PPP1R14C Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PPP1R14C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--


    PPP1R14C for ontologies           About GeneDecksing



    PPP1R14C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PPP1R14C 
    GenScript Custom Superior Antibodies Services for PPP1R14C
    Novus Biologicals PPP1R14C Antibody
    Search for Antibodies for PPP1R14C at Abcam  
    Uscn Antibodies for PPP1R14C
    ThermoFisher Antibodies for PPP1R14C

    Assay Products for PPP1R14C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP1R14C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PPP1R14C


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PPP1R14C for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008025 PP1_inhibitor

    Graphical View of Domain Structure for InterPro Entry Q8TAE6

    ProtoNet protein and cluster: Q8TAE6

    UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
    Similarity: Belongs to the PP1 inhibitor family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
    Function: Inhibitor of the PP1 regulatory subunit PPP1CA

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PPP1R14C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R14C
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R14C (see all 20):
    hsa-miR-30c hsa-miR-3128 hsa-miR-100* hsa-miR-631 hsa-miR-300 hsa-miR-30d hsa-miR-3661 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R14C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R14C (see all 7)
    OriGene shRNA RFP: PPP1R14C
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R14C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP1R14C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R14C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R14C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPP1R14C (NM_030949)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R14C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R14C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP1R14C
    Search LifeMap BioReagents cell lines for PPP1R14C

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R14C

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004865protein serine/threonine phosphatase inhibitor activity IEA--


    PPP1R14C for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PPP1R14C:
     Increased Erk phosphorylation   Upregulation of NF-kappaB path 

    Animal Models:
         Mouse knock-out Ppp1r14ctm1Uhl for PPP1R14C
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp1r14c):
     behavior/neurological  integument  mortality/aging 

    PPP1R14C for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R14C

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for PPP1R14C (Q8TAE63 ENSP000003552604) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAP25Q8TEE93I2D: score=1 
    ILKENSP000002994214STRING: ENSP00000299421
    SIRT3ENSP000003721914STRING: ENSP00000372191
    SIRT5ENSP000003685524STRING: ENSP00000368552
    HDAC6ENSP000003340614STRING: ENSP00000334061
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042325regulation of phosphorylation IEA--


    PPP1R14C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP1R14C for compounds           About GeneDecksing

    EMD Millipore small molecules for PPP1R14C:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R14C
    1 Novoseek chemical compound relationship for PPP1R14C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.4 4 11812771 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP1R14C / PP14C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP1R14C gene: 
    NM_030949.2  

    Unigene Cluster for PPP1R14C:

    Protein phosphatase 1, regulatory (inhibitor) subunit 14C
    Hs.486798  [show with all ESTs]
    Unigene Representative Sequence: AF407165
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361131(uc003qnt.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PPP1R14C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R14C
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R14C (see all 20):
    hsa-miR-30c hsa-miR-3128 hsa-miR-100* hsa-miR-631 hsa-miR-300 hsa-miR-30d hsa-miR-3661 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R14C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R14C (see all 7)
    OriGene shRNA RFP: PPP1R14C
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R14C
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R14C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R14C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPP1R14C (NM_030949)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R14C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R14C 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R14C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP1R14C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R14C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R14C

    Additional cDNA sequence: 

    AF308297.1 AF407165.2 AK092697.1 AK096272.1 BC015773.1 

    1 DOTS entry:

    DT.414582 

    24/85 AceView cDNA sequences (see all 85):

    CA411646 AW276309 F12388 AA670373 AW613012 AI242545 CK819415 AF407165 
    Z41626 AW057524 F10005 AI401474 N44532 BM982254 BQ017225 AA883629 
    BM142095 CK819414 AA741014 AA788675 AW182882 NM_030949 AI336100 AW953750 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R14C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    PPP1R14C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPP1R14C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R14C

    SOURCE GeneReport for Unigene cluster: Hs.486798

    UniProtKB/Swiss-Prot: PP14C_HUMAN, Q8TAE6
    Tissue specificity: Detected in breast cancer

        SABiosciences Expression via Pathway-Focused PCR Array including PPP1R14C: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R14C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP1R14C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R14C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R14C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R14C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R14C gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPP1R14C6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    3(50218911-50269596)
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R14C6
    --
    84(a)
    1 ↔ 1
    GL343259.1(487267-492989)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.112 Transcribed sequence with weak similarity to protein more 82.9(n)    AL874588.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1099841 zgc:109984 70.48(n)
    69.47(a)
      568055  NM_001029963.1  NP_001025134.1 


    ENSEMBL Gene Tree for PPP1R14C (if available)
    TreeFam Gene Tree for PPP1R14C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R14C gene
    PPP1R14A2  PPP1R14D2  PPP1R14B2  
    4 SIMAP similar genes for PPP1R14C using alignment to 2 protein entries:     PP14C_HUMAN (see all proteins):
    PPP1R14B    LIMK2    PPP1R14A    PPP1R14D

    PPP1R14C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2120 NCBI SNPs in PPP1R14C are shown (see all 2120    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166095251,2
    C,F,--150462203(+) GTCATC/TGGTCT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1382143841,2
    --150462215(+) TAGGGA/GCAATC 1 -- us2k10--------
    rs1120598391,2
    C,--150462537(+) CAGAGC/GTGGGC 1 -- us2k12Minor allele frequency- G:0.04NA 122
    rs1811200201,2
    --150462567(+) TGAAGC/TGCCAG 1 -- us2k10--------
    rs1869804491,2
    --150462767(+) ACAAAC/TAAAAA 1 -- us2k10--------
    rs1142654301,2
    F,--150462779(+) AGTTCA/GTGGCC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1917725671,2
    --150462837(+) GCGGGC/TGGATC 1 -- us2k10--------
    rs1164477821,2
    F,--150462935(+) GAAAGC/TCTGTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1836171641,2
    --150462992(+) GAAGTC/GAGAGG 1 -- us2k10--------
    rs132105271,2
    A--150463017(+) gatctC/Tgccac 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP1R14C (150464188 - 150571528 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for PPP1R14C
         12 CNVs: 81639 81636 94094 94095 81640 94093 94096 81638 81641 4511 81637 94097
         2 Indels: 99752 69620

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1R14C
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R14C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PPP1R14C for disorders           About GeneDecksing

    OMIM gene information: 613242    OMIM disorders: --

    7 diseases for PPP1R14C:    About MalaCards
    breast cancer    multiple system atrophy    kawasaki disease    gout
    measles    colon cancer    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: PPP1R14C (2 documents)

    Export disorders for PPP1R14C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R14C gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with PPP1R14C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PubMed id 11812771)1, 2, 9 Liu Q.-R.... Uhl G. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PubMed id 11948623)1, 3 Ceulemans H....Bollen M. (2002)
    5. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2 Scanlan M.J.... Old L.J. (2001)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)1 Soler Artigas M....Tobin M.D. (2011)
    10. Generation of an antibody against the protein phospha tase 1 inhibitor KEPI and characterization of the epitope. (PubMed id 20592344)1 Daskalow K....Schenk J.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81706 HGNC: 14952 AceView: PPP1R14C Ensembl:ENSG00000198729 euGenes: HUgn81706
    ECgene: PPP1R14C H-InvDB: PPP1R14C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R14C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1R14C gene:
    Search GeneIP for patents involving PPP1R14C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore small molecules (inhibitor) for PPP1R14C
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PPP1R14C  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R14C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R14C  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for PPP1R14C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R14C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R14C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP1R14C   OriGene Custom Protein Services for PPP1R14C  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP1R14C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1R14C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R14C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R14C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R14C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R14C
     GenScript Custom Purified and Recombinant Proteins Services for PPP1R14C GenScript cDNA clones with any tag delivered in your preferred vector for PPP1R14C
     GenScript Custom Assay Services for PPP1R14C GenScript Custom Superior Antibodies Services for PPP1R14C
     GenScript Custom overexpressing Cell Line Services for PPP1R14C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PPP1R14C promoter
     Search Chromatin IP Primers for PPP1R14C
     RT2 qPCR Primer Assay in human, mouse, rat PPP1R14C
     GNC Network for PPP1R14C
     SABiosciences PCR Arrays including human, mouse, rat PPP1R14C
     Search Tocris compounds for PPP1R14C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPP1R14C antibodies
     PPP1R14C proteins
     Search for Antibodies for PPP1R14C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PPP1R14C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PPP1R14C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PPP1R14C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R14C
     SwitchGear 3'UTR luciferase reporter plasmids for PPP1R14C
     SwitchGear Promoter luciferase reporter plasmids for PPP1R14C
     ThermoFisher Antibodies for PPP1R14C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R14C
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP1R14C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4