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Aliases for PPP1R14C Gene

Aliases for PPP1R14C Gene

  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C 2 3
  • KEPI 3 4 6
  • Serologically Defined Breast Cancer Antigen NY-BR-81 3 4
  • PKC-Potentiated PP1 Inhibitory Protein 3 4
  • Kinase C-Enhanced PP1 Inhibitor 2 3
  • Kinase-Enhanced PP1 Inhibitor 3 4
  • Protein Phosphatase 1 Regulatory Subunit 14C 3
  • CPI17-Like 3
  • NY-BR-81 3

External Ids for PPP1R14C Gene

Previous GeneCards Identifiers for PPP1R14C Gene

  • GC06P150025
  • GC06P150359
  • GC06P150495
  • GC06P150556
  • GC06P150505
  • GC06P150464
  • GC06P148029

Summaries for PPP1R14C Gene

Entrez Gene Summary for PPP1R14C Gene

  • The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14C Gene

PPP1R14C (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C) is a Protein Coding gene. Diseases associated with PPP1R14C include breast cancer. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot for PPP1R14C Gene

  • Inhibitor of the PP1 regulatory subunit PPP1CA

Gene Wiki entry for PPP1R14C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14C Gene

Genomics for PPP1R14C Gene

Regulatory Elements for PPP1R14C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1R14C Gene

Start:
150,143,052 bp from pter
End:
150,250,392 bp from pter
Size:
107,341 bases
Orientation:
Plus strand

Genomic View for PPP1R14C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14C Gene

Proteins for PPP1R14C Gene

  • Protein details for PPP1R14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE6-PP14C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Protein Accession:
    Q8TAE6
    Secondary Accessions:
    • Q5VY83
    • Q96BB1
    • Q9H277

    Protein attributes for PPP1R14C Gene

    Size:
    165 amino acids
    Molecular mass:
    17843 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG48264.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PPP1R14C Gene

Proteomics data for PPP1R14C Gene at MOPED

Post-translational modifications for PPP1R14C Gene

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14C Gene

Domains for PPP1R14C Gene

Gene Families for PPP1R14C Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R14C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAE6

UniProtKB/Swiss-Prot:

PP14C_HUMAN :
  • Q8TAE6
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14C: view

Function for PPP1R14C Gene

Molecular function for PPP1R14C Gene

UniProtKB/Swiss-Prot Function: Inhibitor of the PP1 regulatory subunit PPP1CA

Gene Ontology (GO) - Molecular Function for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004865 protein serine/threonine phosphatase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view
genes like me logo Genes that share phenotypes with PPP1R14C: view

Animal Models for PPP1R14C Gene

MGI Knock Outs for PPP1R14C:

Animal Model Products

CRISPR Products

miRNA for PPP1R14C Gene

miRTarBase miRNAs that target PPP1R14C

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP1R14C Gene

Localization for PPP1R14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14C Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R14C Gene COMPARTMENTS Subcellular localization image for PPP1R14C gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

Pathways for PPP1R14C Gene

SuperPathways for PPP1R14C Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PPP1R14C Gene

Gene Ontology (GO) - Biological Process for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Pathways by source for PPP1R14C Gene

Compounds for PPP1R14C Gene

(1) Novoseek inferred chemical compound relationships for PPP1R14C Gene

Compound -log(P) Hits PubMed IDs
threonine 44.4 1
genes like me logo Genes that share compounds with PPP1R14C: view

Transcripts for PPP1R14C Gene

mRNA/cDNA for PPP1R14C Gene

(85) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R14C Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R14C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PPP1R14C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14C Gene

No ASD Table

Relevant External Links for PPP1R14C Gene

GeneLoc Exon Structure for
PPP1R14C
ECgene alternative splicing isoforms for
PPP1R14C

Expression for PPP1R14C Gene

mRNA expression in normal human tissues for PPP1R14C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R14C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (7.4), Skin - Not Sun Exposed (Suprapubic) (7.2), Heart - Left Ventricle (6.5), and Heart - Atrial Appendage (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R14C Gene

SOURCE GeneReport for Unigene cluster for PPP1R14C Gene Hs.486798

mRNA Expression by UniProt/SwissProt for PPP1R14C Gene

Q8TAE6-PP14C_HUMAN
Tissue specificity: Detected in breast cancer.
genes like me logo Genes that share expressions with PPP1R14C: view

In Situ Assay Products

Orthologs for PPP1R14C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R14C 35
  • 99.39 (n)
  • 98.79 (a)
PPP1R14C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC783497 35
  • 88.28 (n)
  • 90.91 (a)
PPP1R14C 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
ManyToMany
PPP1R14C 35
  • 94.02 (n)
  • 93.1 (a)
mouse
(Mus musculus)
Mammalia Ppp1r14c 35
  • 86.59 (n)
  • 89.02 (a)
Ppp1r14c 16
Ppp1r14c 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R14C 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R14C 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r14c 35
  • 86.59 (n)
  • 89.63 (a)
chicken
(Gallus gallus)
Aves PPP1R14C 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R14C 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14c 35
  • 82.46 (n)
  • 86.32 (a)
Str.11 35
zebrafish
(Danio rerio)
Actinopterygii ppp1r14c 35
  • 75.89 (n)
  • 79.79 (a)
ppp1r14c 36
  • 69 (a)
OneToMany
ppp1r14c 36
  • 69 (a)
OneToMany
Species with no ortholog for PPP1R14C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14C Gene

ENSEMBL:
Gene Tree for PPP1R14C (if available)
TreeFam:
Gene Tree for PPP1R14C (if available)

Paralogs for PPP1R14C Gene

Paralogs for PPP1R14C Gene

Selected SIMAP similar genes for PPP1R14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPP1R14C: view

Variants for PPP1R14C Gene

Sequence variations from dbSNP and Humsavar for PPP1R14C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1151 -- 150,250,129(+) CGCTG(A/C)CTCCC utr-variant-3-prime
rs746984 -- 150,192,868(+) TCTCA(C/T)CTTTC intron-variant
rs754028 -- 150,172,480(-) TACCC(G/T)CCTCC intron-variant
rs796871 -- 150,246,382(+) CAACA(A/G)AATTG intron-variant
rs877905 -- 150,211,085(-) GCACA(C/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14C Gene

Variant ID Type Subtype PubMed ID
nsv886770 CNV Gain 21882294
nsv5536 CNV Insertion 18451855
esv1003519 CNV Insertion 20482838
esv2434869 CNV Insertion 19546169
nsv5537 CNV Insertion 18451855
nsv830843 CNV Gain+Loss 17160897
esv26363 CNV Gain 19812545
esv260018 OTHER Complex 20981092

Relevant External Links for PPP1R14C Gene

HapMap Linkage Disequilibrium report
PPP1R14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14C Gene

Disorders for PPP1R14C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PPP1R14C Gene including...

Search for PPP1R14C Gene in MalaCards »

Relevant External Links for PPP1R14C

Genetic Association Database (GAD)
PPP1R14C
Human Genome Epidemiology (HuGE) Navigator
PPP1R14C
genes like me logo Genes that share disorders with PPP1R14C: view

No data available for UniProtKB/Swiss-Prot for PPP1R14C Gene

Publications for PPP1R14C Gene

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PMID: 11812771) Liu Q.-R. … Uhl G. (J. Biol. Chem. 2002) 3 4 23
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  3. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPP1R14C Gene

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Sources for PPP1R14C Gene

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