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Aliases for PPP1R14C Gene

Aliases for PPP1R14C Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-81 3 4
  • PKC-Potentiated PP1 Inhibitory Protein 3 4
  • Kinase C-Enhanced PP1 Inhibitor 2 3
  • Kinase-Enhanced PP1 Inhibitor 3 4
  • KEPI 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C 2
  • Protein Phosphatase 1 Regulatory Subunit 14C 3
  • CPI17-Like 3
  • NY-BR-81 3

External Ids for PPP1R14C Gene

Previous GeneCards Identifiers for PPP1R14C Gene

  • GC06P150025
  • GC06P150359
  • GC06P150495
  • GC06P150556
  • GC06P150505
  • GC06P150464
  • GC06P148029

Summaries for PPP1R14C Gene

Entrez Gene Summary for PPP1R14C Gene

  • The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14C Gene

PPP1R14C (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot for PPP1R14C Gene

  • Inhibitor of the PP1 regulatory subunit PPP1CA.

Gene Wiki entry for PPP1R14C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14C Gene

Genomics for PPP1R14C Gene

Regulatory Elements for PPP1R14C Gene

Enhancers for PPP1R14C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F150200 1 Ensembl ENCODE 20.8 +58.8 58830 2.8 BCOR PKNOX1 ZNF146 ESRRA ZMYM3 SCRT2 FOSL2 FOS ZNF263 SMARCA5 PPP1R14C ENSG00000238594 RNU4-7P IYD LOC105378054
GH06F150250 1.6 FANTOM5 Ensembl ENCODE 10.8 +111.4 111357 8.0 PKNOX1 ATF1 FEZF1 ZNF2 YY1 GLIS2 GATA2 KLF7 FOS ZNF263 NUP43 PPIL4 ENSG00000231760 KATNA1 LATS1 ENSG00000238594 PPP1R14C RAET1G ULBP2 RAET1L
GH06F150266 1.7 FANTOM5 Ensembl ENCODE 9.1 +127.3 127318 8.3 HDGF PKNOX1 ARNT FEZF1 ZNF2 YY1 CBX5 ZNF416 FOS KLF13 LATS1 NUP43 PPIL4 KATNA1 ENSG00000231760 RNU4-7P RPS18P9 ENSG00000202343 ENSG00000238594 ENSG00000233330
GH06F150072 1.1 Ensembl ENCODE 11 -71.8 -71752 0.6 CTCF ZNF384 ZNF2 RAD21 ZEB1 ZNF324 ZNF366 ZNF143 SMC3 PRDM10 PPP1R14C IYD ULBP3
GH06F150071 1.1 Ensembl ENCODE 11 -70.8 -70752 1.0 HDGF PKNOX1 KLF17 GLIS2 ZNF366 SCRT2 RCOR1 KLF7 FOS KLF13 ULBP3 PPP1R14C IYD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R14C on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R14C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001501490 548 2400 PKNOX1 FEZF1 GLI4 ZNF2 GLIS2 KLF7 ZNF548 ZNF263 SP3 REST

Genomic Location for PPP1R14C Gene

Chromosome:
6
Start:
150,143,052 bp from pter
End:
150,250,392 bp from pter
Size:
107,341 bases
Orientation:
Plus strand

Genomic View for PPP1R14C Gene

Genes around PPP1R14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14C Gene

Proteins for PPP1R14C Gene

  • Protein details for PPP1R14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE6-PP14C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Protein Accession:
    Q8TAE6
    Secondary Accessions:
    • Q5VY83
    • Q96BB1
    • Q9H277

    Protein attributes for PPP1R14C Gene

    Size:
    165 amino acids
    Molecular mass:
    17843 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG48264.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PPP1R14C Gene

Post-translational modifications for PPP1R14C Gene

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14C Gene

Domains & Families for PPP1R14C Gene

Gene Families for PPP1R14C Gene

Protein Domains for PPP1R14C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAE6

UniProtKB/Swiss-Prot:

PP14C_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14C: view

Function for PPP1R14C Gene

Molecular function for PPP1R14C Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the PP1 regulatory subunit PPP1CA.

Gene Ontology (GO) - Molecular Function for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004865 protein serine/threonine phosphatase inhibitor activity IEA,IBA --
genes like me logo Genes that share ontologies with PPP1R14C: view
genes like me logo Genes that share phenotypes with PPP1R14C: view

Animal Models for PPP1R14C Gene

MGI Knock Outs for PPP1R14C:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R14C Gene

Localization for PPP1R14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14C Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14C gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

Pathways & Interactions for PPP1R14C Gene

SuperPathways for PPP1R14C Gene

No Data Available

SIGNOR curated interactions for PPP1R14C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035304 regulation of protein dephosphorylation IBA --
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IBA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Pathways by source for PPP1R14C Gene

Drugs & Compounds for PPP1R14C Gene

(1) Drugs for PPP1R14C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R14C: view

Transcripts for PPP1R14C Gene

mRNA/cDNA for PPP1R14C Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R14C Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14C Gene

No ASD Table

Relevant External Links for PPP1R14C Gene

GeneLoc Exon Structure for
PPP1R14C
ECgene alternative splicing isoforms for
PPP1R14C

Expression for PPP1R14C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R14C Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R14C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.2), Heart - Left Ventricle (x6.5), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for PPP1R14C Gene

This gene is overexpressed in Adipocyte (37.9), Fetal heart (14.2), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R14C Gene



Protein tissue co-expression partners for PPP1R14C Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R14C Gene:

PPP1R14C

SOURCE GeneReport for Unigene cluster for PPP1R14C Gene:

Hs.486798

mRNA Expression by UniProt/SwissProt for PPP1R14C Gene:

Q8TAE6-PP14C_HUMAN
Tissue specificity: Detected in breast cancer.
genes like me logo Genes that share expression patterns with PPP1R14C: view

Primer Products

Orthologs for PPP1R14C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R14C 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia PPP1R14C 34
  • 94.02 (n)
-- 35
  • 60 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PPP1R14C 35
  • 92 (a)
OneToOne
LOC783497 34
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Ppp1r14c 34 16 35
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Ppp1r14c 34
  • 86.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R14C 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R14C 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1R14C 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R14C 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14c 34
  • 82.46 (n)
Str.11 34
zebrafish
(Danio rerio)
Actinopterygii ppp1r14c 34 35 35
  • 75.89 (n)
Species where no ortholog for PPP1R14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14C Gene

ENSEMBL:
Gene Tree for PPP1R14C (if available)
TreeFam:
Gene Tree for PPP1R14C (if available)

Paralogs for PPP1R14C Gene

Paralogs for PPP1R14C Gene

(4) SIMAP similar genes for PPP1R14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPP1R14C: view

Variants for PPP1R14C Gene

Sequence variations from dbSNP and Humsavar for PPP1R14C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080687 -- 150,217,950(+) TTGAT(G/T)ACATC intron-variant
rs10214734 -- 150,163,247(+) ttagc(C/T)gggca intron-variant
rs1040661 -- 150,237,574(-) TCATC(A/G)TTATC intron-variant
rs1044672 -- 150,249,216(+) TTGTA(C/T)ATTTG utr-variant-3-prime
rs10457859 -- 150,175,854(+) TGCAG(A/T)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14C Gene

Variant ID Type Subtype PubMed ID
nsv830843 CNV gain+loss 17160897
nsv604848 CNV gain 21841781
nsv5537 CNV insertion 18451855
nsv5536 CNV insertion 18451855
nsv477214 CNV novel sequence insertion 20440878
nsv1151745 CNV insertion 26484159
nsv1148196 CNV insertion 26484159
nsv1141828 CNV insertion 24896259
nsv1140712 CNV deletion 24896259
nsv1026690 CNV gain 25217958
esv3890963 CNV loss 25118596
esv3611228 CNV loss 21293372
esv3576235 CNV gain 25503493
esv3571462 CNV loss 25503493
esv3571450 CNV loss 25503493
esv3303044 CNV tandem duplication 20981092
esv26363 CNV gain 19812545
esv2434869 CNV insertion 19546169
esv1003519 CNV insertion 20482838
dgv1840e212 CNV loss 25503493
dgv1839e212 CNV loss 25503493

Variation tolerance for PPP1R14C Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14C Gene

Disorders for PPP1R14C Gene

Relevant External Links for PPP1R14C

Genetic Association Database (GAD)
PPP1R14C
Human Genome Epidemiology (HuGE) Navigator
PPP1R14C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R14C

No disorders were found for PPP1R14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14C Gene

Publications for PPP1R14C Gene

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PMID: 11812771) Liu Q.-R. … Uhl G. (J. Biol. Chem. 2002) 3 4 22 64
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 46 64
  3. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D. … Hibberd M.L. (PLoS Genet. 2009) 3 46 64
  4. SNCA variants are associated with increased risk for multiple system atrophy. (PMID: 19475667) Scholz S.W. … Gasser T. (Ann. Neurol. 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PPP1R14C Gene

Sources for PPP1R14C Gene

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