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Aliases for PPP1R14B Gene

Aliases for PPP1R14B Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B 2 3 5
  • Phospholipase C-Beta-3 Neighbouring Gene Protein 3 4
  • PLCB3N 3 4
  • PNG 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14B 2
  • Phospholipase C Beta-3 Neighboring Gene Protein 3
  • Protein Phosphatase 1 Regulatory Subunit 14B 3
  • SOM172 3
  • PHI-1 3

External Ids for PPP1R14B Gene

Previous HGNC Symbols for PPP1R14B Gene

  • PLCB3N

Previous GeneCards Identifiers for PPP1R14B Gene

  • GC11M066527
  • GC11M065693
  • GC11M064262
  • GC11M063787
  • GC11M063768
  • GC11M064011
  • GC11M060339

Summaries for PPP1R14B Gene

GeneCards Summary for PPP1R14B Gene

PPP1R14B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and ERK Signaling. GO annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14C.

UniProtKB/Swiss-Prot for PPP1R14B Gene

  • Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).

Gene Wiki entry for PPP1R14B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14B Gene

Genomics for PPP1R14B Gene

Regulatory Elements for PPP1R14B Gene

Enhancers for PPP1R14B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064237 1.4 ENCODE dbSUPER 22.6 +1.6 1623 16.6 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000257086 TRMT112 TRPT1 ZFPL1 PPP1R14B LOC102723878 VEGFB KCNK4 PLCB3 FERMT3
GH11G064215 0.6 ENCODE 12.5 +31.7 31728 0.1 ZNF335 ZFHX2 HLF ZNF341 CEBPB FOS FKBP2 PPP1R14B ENSG00000257086 LOC105369340 PLCB3 GPR137 BAD MACROD1 FERMT3 NUDT22
GH11G064354 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.7 -111.0 -111034 6.6 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF207 PLCB3 LOC102723878 ZFPL1 ENSG00000257086 POLA2 VPS51 ATG2A CDC42BPG MRPL49 SNX15
GH11G064874 1.4 ENCODE dbSUPER 4.9 -630.8 -630839 7.1 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZFPL1 PCNX3 TRMT112 FRMD8 PLCB3 KAT5 FAU POLA2 CDC42BPG PPP1R14B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R14B on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R14B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040638 341 2401 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for PPP1R14B Gene

Chromosome:
11
Start:
64,244,479 bp from pter
End:
64,246,941 bp from pter
Size:
2,463 bases
Orientation:
Minus strand

Genomic View for PPP1R14B Gene

Genes around PPP1R14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14B Gene

Proteins for PPP1R14B Gene

  • Protein details for PPP1R14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C90-PP14B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14B
    Protein Accession:
    Q96C90
    Secondary Accessions:
    • Q504S7
    • Q7KZD7

    Protein attributes for PPP1R14B Gene

    Size:
    147 amino acids
    Molecular mass:
    15911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R14B Gene

Post-translational modifications for PPP1R14B Gene

  • Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14B Gene

Domains & Families for PPP1R14B Gene

Gene Families for PPP1R14B Gene

Protein Domains for PPP1R14B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C90

UniProtKB/Swiss-Prot:

PP14B_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14B: view

Function for PPP1R14B Gene

Molecular function for PPP1R14B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0019212 phosphatase inhibitor activity IEA --
GO:0019888 protein phosphatase regulator activity IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view
genes like me logo Genes that share phenotypes with PPP1R14B: view

Animal Model Products

CRISPR Products

miRNA for PPP1R14B Gene

miRTarBase miRNAs that target PPP1R14B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R14B Gene

Localization for PPP1R14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view

Pathways & Interactions for PPP1R14B Gene

genes like me logo Genes that share pathways with PPP1R14B: view

Gene Ontology (GO) - Biological Process for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with PPP1R14B: view

No data available for SIGNOR curated interactions for PPP1R14B Gene

Drugs & Compounds for PPP1R14B Gene

No Compound Related Data Available

Transcripts for PPP1R14B Gene

mRNA/cDNA for PPP1R14B Gene

Unigene Clusters for PPP1R14B Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14B Gene

No ASD Table

Relevant External Links for PPP1R14B Gene

GeneLoc Exon Structure for
PPP1R14B
ECgene alternative splicing isoforms for
PPP1R14B

Expression for PPP1R14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R14B Gene

Protein differential expression in normal tissues from HIPED for PPP1R14B Gene

This gene is overexpressed in Heart (16.2) and Amniocyte (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R14B Gene



Protein tissue co-expression partners for PPP1R14B Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R14B Gene:

PPP1R14B

SOURCE GeneReport for Unigene cluster for PPP1R14B Gene:

Hs.523760

mRNA Expression by UniProt/SwissProt for PPP1R14B Gene:

Q96C90-PP14B_HUMAN
Tissue specificity: Ubiquitous. Expressed at low levels.

Evidence on tissue expression from TISSUES for PPP1R14B Gene

  • Skin(4.2)
  • Muscle(2.7)
  • Liver(2)
genes like me logo Genes that share expression patterns with PPP1R14B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14B Gene

Orthologs for PPP1R14B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R14B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia PPP1R14B 34
  • 92.56 (n)
-- 35
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ppp1r14b 34
  • 89.8 (n)
mouse
(Mus musculus)
Mammalia Ppp1r14b 34 16
  • 89.34 (n)
4933415F23Rik 35
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R14B 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14b 34
  • 74.63 (n)
Str.7221 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23861 34
zebrafish
(Danio rerio)
Actinopterygii ppp1r14bb 34 35
  • 71.88 (n)
ppp1r14ba 35
  • 67 (a)
OneToMany
ppp1r14b 34
Species where no ortholog for PPP1R14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14B Gene

ENSEMBL:
Gene Tree for PPP1R14B (if available)
TreeFam:
Gene Tree for PPP1R14B (if available)

Paralogs for PPP1R14B Gene

Paralogs for PPP1R14B Gene

(4) SIMAP similar genes for PPP1R14B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP1R14B Gene

genes like me logo Genes that share paralogs with PPP1R14B: view

Variants for PPP1R14B Gene

Sequence variations from dbSNP and Humsavar for PPP1R14B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000379419 -- 64,246,632(+) GCCGG(A/G)GCCGC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000981937 -- 64,244,972(+) CAGAG(A/G)ATGGG intron-variant, upstream-variant-2KB
rs1001294271 -- 64,248,221(+) CTACA(-/C)CCACA intron-variant, upstream-variant-2KB
rs1001341927 -- 64,244,465(+) AAGAG(A/C)CCAGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001394854 -- 64,247,238(+) GGACA(C/T)CGTGT intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14B Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv24861 CNV gain 19812545
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366
nsv983032 CNV duplication 23825009

Variation tolerance for PPP1R14B Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14B Gene

Disorders for PPP1R14B Gene

Relevant External Links for PPP1R14B

Genetic Association Database (GAD)
PPP1R14B
Human Genome Epidemiology (HuGE) Navigator
PPP1R14B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R14B

No disorders were found for PPP1R14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14B Gene

Publications for PPP1R14B Gene

  1. Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. (PMID: 8838322) Lagercrantz J. … Weber G. (Genomics 1996) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. (PMID: 15522888) Tountas N.A. … Brautigan D.L. (J. Cell. Sci. 2004) 3 22 64

Products for PPP1R14B Gene

Sources for PPP1R14B Gene

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