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Aliases for PPP1R14B Gene

Aliases for PPP1R14B Gene

  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14B 2 3
  • Phospholipase C-Beta-3 Neighbouring Gene Protein 3 4
  • PLCB3N 3 4
  • PNG 3 4
  • Phospholipase C Beta-3 Neighboring Gene Protein 3
  • SOM172 3
  • PHI-1 3

External Ids for PPP1R14B Gene

Previous HGNC Symbols for PPP1R14B Gene

  • PLCB3N

Previous GeneCards Identifiers for PPP1R14B Gene

  • GC11M066527
  • GC11M065693
  • GC11M064262
  • GC11M063787
  • GC11M063768
  • GC11M064011
  • GC11M060339

Summaries for PPP1R14B Gene

GeneCards Summary for PPP1R14B Gene

PPP1R14B (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14B) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. GO annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14A.

UniProtKB/Swiss-Prot for PPP1R14B Gene

  • Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).

Gene Wiki entry for PPP1R14B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14B Gene

Genomics for PPP1R14B Gene

Regulatory Elements for PPP1R14B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1R14B Gene

Chromosome:
11
Start:
64,244,479 bp from pter
End:
64,246,941 bp from pter
Size:
2,463 bases
Orientation:
Minus strand

Genomic View for PPP1R14B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14B Gene

Proteins for PPP1R14B Gene

  • Protein details for PPP1R14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C90-PP14B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14B
    Protein Accession:
    Q96C90
    Secondary Accessions:
    • Q504S7
    • Q7KZD7

    Protein attributes for PPP1R14B Gene

    Size:
    147 amino acids
    Molecular mass:
    15911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R14B Gene

Proteomics data for PPP1R14B Gene at MOPED

Post-translational modifications for PPP1R14B Gene

  • Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14B Gene

Domains & Families for PPP1R14B Gene

Gene Families for PPP1R14B Gene

Protein Domains for PPP1R14B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C90

UniProtKB/Swiss-Prot:

PP14B_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14B: view

Function for PPP1R14B Gene

Molecular function for PPP1R14B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view
genes like me logo Genes that share phenotypes with PPP1R14B: view

Animal Model Products

CRISPR Products

miRNA for PPP1R14B Gene

miRTarBase miRNAs that target PPP1R14B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R14B Gene

Localization for PPP1R14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view

No data available for Subcellular locations from COMPARTMENTS for PPP1R14B Gene

Pathways & Interactions for PPP1R14B Gene

genes like me logo Genes that share pathways with PPP1R14B: view

Gene Ontology (GO) - Biological Process for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view

No data available for SIGNOR curated interactions for PPP1R14B Gene

Drugs & Compounds for PPP1R14B Gene

No Compound Related Data Available

Transcripts for PPP1R14B Gene

mRNA/cDNA for PPP1R14B Gene

Unigene Clusters for PPP1R14B Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R14B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14B Gene

No ASD Table

Relevant External Links for PPP1R14B Gene

GeneLoc Exon Structure for
PPP1R14B
ECgene alternative splicing isoforms for
PPP1R14B

Expression for PPP1R14B Gene

mRNA expression in normal human tissues for PPP1R14B Gene

Protein differential expression in normal tissues from HIPED for PPP1R14B Gene

This gene is overexpressed in Heart (16.2) and Amniocyte (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R14B Gene



SOURCE GeneReport for Unigene cluster for PPP1R14B Gene Hs.523760

mRNA Expression by UniProt/SwissProt for PPP1R14B Gene

Q96C90-PP14B_HUMAN
Tissue specificity: Ubiquitous. Expressed at low levels.
genes like me logo Genes that share expression patterns with PPP1R14B: view

Protein tissue co-expression partners for PPP1R14B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP1R14B Gene

Orthologs for PPP1R14B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPP1R14B 35
  • 92.56 (n)
  • 99.17 (a)
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppp1r14b 35
  • 89.34 (n)
  • 96.6 (a)
Ppp1r14b 16
4933415F23Rik 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R14B 35
  • 100 (n)
  • 100 (a)
PPP1R14B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r14b 35
  • 89.8 (n)
  • 96.6 (a)
cow
(Bos Taurus)
Mammalia PPP1R14B 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14b 35
  • 74.63 (n)
  • 83.19 (a)
Str.7221 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23861 35
zebrafish
(Danio rerio)
Actinopterygii ppp1r14b 35
ppp1r14bb 35
  • 71.88 (n)
  • 80 (a)
ppp1r14ba 36
  • 67 (a)
OneToMany
ppp1r14bb 36
  • 74 (a)
OneToMany
Species with no ortholog for PPP1R14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14B Gene

ENSEMBL:
Gene Tree for PPP1R14B (if available)
TreeFam:
Gene Tree for PPP1R14B (if available)

Paralogs for PPP1R14B Gene

Paralogs for PPP1R14B Gene

(4) SIMAP similar genes for PPP1R14B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP1R14B Gene

genes like me logo Genes that share paralogs with PPP1R14B: view

Variants for PPP1R14B Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14B Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv24861 CNV Gain 19812545

Variation tolerance for PPP1R14B Gene

Residual Variation Intolerance Score: 56.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R14B Gene

HapMap Linkage Disequilibrium report
PPP1R14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PPP1R14B Gene

Disorders for PPP1R14B Gene

Relevant External Links for PPP1R14B

Genetic Association Database (GAD)
PPP1R14B
Human Genome Epidemiology (HuGE) Navigator
PPP1R14B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R14B
genes like me logo Genes that share disorders with PPP1R14B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14B Gene

Publications for PPP1R14B Gene

  1. Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. (PMID: 15522888) Tountas N.A. … Brautigan D.L. (J. Cell. Sci. 2004) 23 67
  2. Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. (PMID: 12804574) Erdodi F. … Hartshorne D.J. (Biochem. Biophys. Res. Commun. 2003) 23 67
  3. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. (PMID: 12144526) Deng J.T. … Walsh M.P. (Biochem. J. 2002) 23 67
  4. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. (PMID: 11287002) MacDonald J.A. … Haystead T.A. (FEBS Lett. 2001) 23 67
  5. A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. (PMID: 10606530) Eto M. … Brautigan D.L. (Biochemistry 1999) 2 67

Products for PPP1R14B Gene

Sources for PPP1R14B Gene

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