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Aliases for PPP1R13L Gene

Aliases for PPP1R13L Gene

  • Protein Phosphatase 1 Regulatory Subunit 13 Like 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 13 Like 2 3
  • Protein Phosphatase 1, Regulatory Subunit 13 Like 2 3
  • NFkB-Interacting Protein 1 3 4
  • Inhibitor Of ASPP Protein 3 4
  • PPP1R13B-Like Protein 3 4
  • Protein IASPP 3 4
  • IASPP 3 4
  • NKIP1 3 4
  • RAI 3 4
  • Inhibitor Of Apoptosis Stimulating Protein Of P53 3
  • NFkB Interacting Protein 1 3
  • Retinoic Acid Induced 4 3
  • PPP1R13BL 4
  • RAI4 3

External Ids for PPP1R13L Gene

Previous GeneCards Identifiers for PPP1R13L Gene

  • GC19M050575
  • GC19M045883
  • GC19M042315

Summaries for PPP1R13L Gene

Entrez Gene Summary for PPP1R13L Gene

  • IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

GeneCards Summary for PPP1R13L Gene

PPP1R13L (Protein Phosphatase 1 Regulatory Subunit 13 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include identical protein binding and transcription corepressor activity. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R13L Gene

  • Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

Gene Wiki entry for PPP1R13L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R13L Gene

Genomics for PPP1R13L Gene

Regulatory Elements for PPP1R13L Gene

Promoters for PPP1R13L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R13L on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPP1R13L gene promoter:

Genomic Location for PPP1R13L Gene

Chromosome:
19
Start:
45,379,634 bp from pter
End:
45,406,349 bp from pter
Size:
26,716 bases
Orientation:
Minus strand

Genomic View for PPP1R13L Gene

Genes around PPP1R13L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R13L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R13L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R13L Gene

Proteins for PPP1R13L Gene

  • Protein details for PPP1R13L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUF5-IASPP_HUMAN
    Recommended name:
    RelA-associated inhibitor
    Protein Accession:
    Q8WUF5
    Secondary Accessions:
    • Q2PNZ9
    • Q5DU71
    • Q5I1X4
    • Q6P1R7
    • Q6PKF8
    • Q9Y290

    Protein attributes for PPP1R13L Gene

    Size:
    828 amino acids
    Molecular mass:
    89091 Da
    Quaternary structure:
    • Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.
    SequenceCaution:
    • Sequence=AAD27004.1; Type=Frameshift; Positions=439, 483, 562, 591; Evidence={ECO:0000305}; Sequence=AAD27005.1; Type=Frameshift; Positions=483, 562, 591; Evidence={ECO:0000305}; Sequence=AAD27005.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPP1R13L Gene

neXtProt entry for PPP1R13L Gene

Proteomics data for PPP1R13L Gene at MOPED

Post-translational modifications for PPP1R13L Gene

  • Ubiquitination at Lys 541
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1R13L Gene

Antibody Products

No data available for DME Specific Peptides for PPP1R13L Gene

Domains & Families for PPP1R13L Gene

Gene Families for PPP1R13L Gene

Protein Domains for PPP1R13L Gene

Suggested Antigen Peptide Sequences for PPP1R13L Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUF5

UniProtKB/Swiss-Prot:

IASPP_HUMAN :
  • Isoform 1 N-terminal region is required for cytoplasmic localization.
  • Belongs to the ASPP family.
  • Contains 2 ANK repeats.
Domain:
  • Isoform 1 N-terminal region is required for cytoplasmic localization.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ASPP family.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with PPP1R13L: view

Function for PPP1R13L Gene

Molecular function for PPP1R13L Gene

UniProtKB/Swiss-Prot Function:
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

Gene Ontology (GO) - Molecular Function for PPP1R13L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with PPP1R13L: view
genes like me logo Genes that share phenotypes with PPP1R13L: view

Animal Models for PPP1R13L Gene

MGI Knock Outs for PPP1R13L:

Animal Model Products

CRISPR Products

miRNA for PPP1R13L Gene

miRTarBase miRNAs that target PPP1R13L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R13L Gene

Localization for PPP1R13L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R13L Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R13L Gene COMPARTMENTS Subcellular localization image for PPP1R13L gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3

Gene Ontology (GO) - Cellular Components for PPP1R13L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with PPP1R13L: view

Pathways & Interactions for PPP1R13L Gene

genes like me logo Genes that share pathways with PPP1R13L: view

Gene Ontology (GO) - Biological Process for PPP1R13L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006915 apoptotic process IEA --
GO:0009791 post-embryonic development IEA --
GO:0031076 embryonic camera-type eye development IEA --
GO:0035264 multicellular organism growth IEA --
genes like me logo Genes that share ontologies with PPP1R13L: view

No data available for SIGNOR curated interactions for PPP1R13L Gene

Drugs & Compounds for PPP1R13L Gene

(1) Drugs for PPP1R13L Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
genes like me logo Genes that share compounds with PPP1R13L: view

Transcripts for PPP1R13L Gene

Unigene Clusters for PPP1R13L Gene

Protein phosphatase 1, regulatory subunit 13 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R13L Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3: -

Relevant External Links for PPP1R13L Gene

GeneLoc Exon Structure for
PPP1R13L
ECgene alternative splicing isoforms for
PPP1R13L

Expression for PPP1R13L Gene

mRNA expression in normal human tissues for PPP1R13L Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R13L Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.8), Skin - Not Sun Exposed (Suprapubic) (x6.8), and Esophagus - Mucosa (x5.2).

Protein differential expression in normal tissues from HIPED for PPP1R13L Gene

This gene is overexpressed in Cervix (30.3), Urine (14.8), and Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R13L Gene



SOURCE GeneReport for Unigene cluster for PPP1R13L Gene Hs.466937

mRNA Expression by UniProt/SwissProt for PPP1R13L Gene

Q8WUF5-IASPP_HUMAN
Tissue specificity: Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
genes like me logo Genes that share expression patterns with PPP1R13L: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for PPP1R13L Gene

Orthologs for PPP1R13L Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R13L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R13L 35
  • 86.43 (n)
  • 88.94 (a)
PPP1R13L 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r13l 35
  • 82.81 (n)
  • 88.83 (a)
Ppp1r13l 16
Ppp1r13l 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R13L 35
  • 99.36 (n)
  • 99.64 (a)
PPP1R13L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r13l 35
  • 82.97 (n)
  • 88.69 (a)
dog
(Canis familiaris)
Mammalia PPP1R13L 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R13L 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R13L 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R13L 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6245 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19607 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19303 35
ppp1r13l 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ASPP 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ape-1 36
  • 20 (a)
ManyToMany
mel-11 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for PPP1R13L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R13L Gene

ENSEMBL:
Gene Tree for PPP1R13L (if available)
TreeFam:
Gene Tree for PPP1R13L (if available)

Paralogs for PPP1R13L Gene

Paralogs for PPP1R13L Gene

(5) SIMAP similar genes for PPP1R13L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP1R13L: view

Variants for PPP1R13L Gene

Sequence variations from dbSNP and Humsavar for PPP1R13L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs6966 -- 45,379,704(-) ACAGC(A/T)CTGGT utr-variant-3-prime
rs2017104 -- 45,384,007(-) cgggc(A/G)gattg intron-variant
rs2017154 -- 45,383,932(-) taaaa(A/C)aattt intron-variant
rs2070830 -- 45,386,392(-) CCCAA(G/T)ATTCT intron-variant
rs1970764 -- 45,387,615(-) atcgc(A/G)ccact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R13L Gene

Variant ID Type Subtype PubMed ID
nsv833844 CNV Loss 17160897
nsv833845 CNV Loss 17160897
nsv458711 CNV Gain 19166990
nsv442466 CNV CNV 18776908
nsv428365 CNV Gain+Loss 18775914
nsv833846 CNV Loss 17160897
dgv648e199 CNV Deletion 23128226
esv6828 CNV Loss 19470904

Variation tolerance for PPP1R13L Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R13L Gene

HapMap Linkage Disequilibrium report
PPP1R13L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R13L Gene

Disorders for PPP1R13L Gene

Relevant External Links for PPP1R13L

Genetic Association Database (GAD)
PPP1R13L
Human Genome Epidemiology (HuGE) Navigator
PPP1R13L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R13L

No disorders were found for PPP1R13L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R13L Gene

Publications for PPP1R13L Gene

  1. Identification of a novel inhibitor of nuclear factor-kappaB, RelA- associated inhibitor. (PMID: 10336463) Yang J.-P. … Okamoto T. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins. (PMID: 19246451) Ahn J. … Gronenborn A.M. (J. Biol. Chem. 2009) 3 23
  3. A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study. (PMID: 18289367) Hansen R.D. … Vogel U. (BMC Cancer 2008) 3 23
  4. Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP. (PMID: 18588689) NexA … rglum A.D. (BMC Med. Genet. 2008) 3 23
  5. Expression of the RAI gene is conducive to apoptosis: studies of induction and interference. (PMID: 17570360) Laska M.J. … B.A. (Exp. Cell Res. 2007) 3 23

Products for PPP1R13L Gene

Sources for PPP1R13L Gene

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