Aliases for PPP1R13L Gene
External Ids for PPP1R13L Gene
Previous GeneCards Identifiers for PPP1R13L Gene
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
GeneCards Summary for PPP1R13L Gene
PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like) is a Protein Coding gene. Diseases associated with PPP1R13L include basal cell carcinoma, multiple. Among its related pathways are Integrated Pancreatic Cancer Pathway and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include identical protein binding and transcription corepressor activity. An important paralog of this gene is PPP1R12C.
UniProtKB/Swiss-Prot for PPP1R13L Gene
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.