Aliases for PPP1R13L Gene
External Ids for PPP1R13L Gene
Previous GeneCards Identifiers for PPP1R13L Gene
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
GeneCards Summary for PPP1R13L Gene
PPP1R13L (Protein Phosphatase 1 Regulatory Subunit 13 Like) is a Protein Coding gene. Diseases associated with PPP1R13L include Leopard Syndrome and Noonan Syndrome With Multiple Lentigines. Among its related pathways are p53 pathway (Pathway Interaction Database) and Regulation of TP53 Activity. GO annotations related to this gene include identical protein binding and transcription corepressor activity. An important paralog of this gene is TP53BP2.
UniProtKB/Swiss-Prot for PPP1R13L Gene
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.