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Aliases for PPP1R13B Gene

Aliases for PPP1R13B Gene

  • Protein Phosphatase 1, Regulatory Subunit 13B 2 3
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 13B 2 3
  • Protein Phosphatase 1 Regulatory Subunit 13B 3 4
  • ASPP1 3 4
  • Apoptosis-Stimulating Protein Of P53, 1 3
  • Apoptosis-Stimulating Of P53 Protein 1 3
  • P53BP2-Like 3
  • KIAA0771 4
  • P85 3

External Ids for PPP1R13B Gene

Previous GeneCards Identifiers for PPP1R13B Gene

  • GC14M101591
  • GC14M098015
  • GC14M102190
  • GC14M103271
  • GC14M104200
  • GC14M084378

Summaries for PPP1R13B Gene

Entrez Gene Summary for PPP1R13B Gene

  • This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1R13B Gene

PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R13B Gene

  • Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.

Gene Wiki entry for PPP1R13B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R13B Gene

Genomics for PPP1R13B Gene

Regulatory Elements for PPP1R13B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1R13B Gene

Start:
103,733,751 bp from pter
End:
103,848,484 bp from pter
Size:
114,734 bases
Orientation:
Minus strand

Genomic View for PPP1R13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R13B Gene

Proteins for PPP1R13B Gene

  • Protein details for PPP1R13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KQ4-ASPP1_HUMAN
    Recommended name:
    Apoptosis-stimulating of p53 protein 1
    Protein Accession:
    Q96KQ4
    Secondary Accessions:
    • B2RMX5
    • O94870

    Protein attributes for PPP1R13B Gene

    Size:
    1090 amino acids
    Molecular mass:
    119565 Da
    Quaternary structure:
    • Interacts with TP53.
    Miscellaneous:
    • In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1

neXtProt entry for PPP1R13B Gene

Proteomics data for PPP1R13B Gene at MOPED

Post-translational modifications for PPP1R13B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R13B Gene

Antibody Products

No data available for DME Specific Peptides for PPP1R13B Gene

Domains for PPP1R13B Gene

Gene Families for PPP1R13B Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R13B Gene

Graphical View of Domain Structure for InterPro Entry

Q96KQ4

UniProtKB/Swiss-Prot:

ASPP1_HUMAN :
  • Q96KQ4
Domain:
  • The ankyrin repeats and the SH3 domain are required for specific interactions with TP53
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ASPP family.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with PPP1R13B: view

Function for PPP1R13B Gene

Molecular function for PPP1R13B Gene

UniProtKB/Swiss-Prot Function:
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.

Gene Ontology (GO) - Molecular Function for PPP1R13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11684014
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with PPP1R13B: view
genes like me logo Genes that share phenotypes with PPP1R13B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R13B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1R13B Gene

Localization for PPP1R13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R13B Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R13B Gene COMPARTMENTS Subcellular localization image for PPP1R13B gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for PPP1R13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11684014
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 15782125
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PPP1R13B: view

Pathways for PPP1R13B Gene

genes like me logo Genes that share pathways with PPP1R13B: view

Pathways by source for PPP1R13B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPP1R13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0045786 negative regulation of cell cycle TAS 14729977
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA 11684014
genes like me logo Genes that share ontologies with PPP1R13B: view

Transcripts for PPP1R13B Gene

Unigene Clusters for PPP1R13B Gene

Protein phosphatase 1, regulatory subunit 13B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R13B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R13B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - -
SP2:
SP3:
SP4: - - -
SP5: - - - - - -
SP6:
SP7: -
SP8:
SP9: - - - - - - -
SP10: -
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b
SP1:
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11: - - -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for PPP1R13B Gene

GeneLoc Exon Structure for
PPP1R13B
ECgene alternative splicing isoforms for
PPP1R13B

Expression for PPP1R13B Gene

mRNA expression in normal human tissues for PPP1R13B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PPP1R13B Gene

This gene is overexpressed in Testis (15.7), Colon (8.4), Retina (8.1), Fetal gut (7.9), and Frontal cortex (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R13B Gene

SOURCE GeneReport for Unigene cluster for PPP1R13B Gene Hs.709297

mRNA Expression by UniProt/SwissProt for PPP1R13B Gene

Q96KQ4-ASPP1_HUMAN
Tissue specificity: Reduced expression in breast carcinomas expressing a wild-type TP53 protein.
genes like me logo Genes that share expressions with PPP1R13B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for PPP1R13B Gene

Orthologs for PPP1R13B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R13B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R13B 35
  • 86.07 (n)
  • 90.31 (a)
PPP1R13B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R13B 35
  • 87.95 (n)
  • 92.16 (a)
PPP1R13B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r13b 35
  • 86.05 (n)
  • 92.09 (a)
Ppp1r13b 16
Ppp1r13b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R13B 35
  • 99.51 (n)
  • 99.45 (a)
PPP1R13B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r13b 35
  • 83.88 (n)
  • 89.73 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R13B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R13B 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1R13B 35
  • 74.41 (n)
  • 82.22 (a)
PPP1R13B 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R13B 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r13b 35
  • 68.53 (n)
  • 74.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11488 35
zebrafish
(Danio rerio)
Actinopterygii ppp1r13bb 35
  • 65.31 (n)
  • 70.5 (a)
sbcb375 35
ppp1r13ba 36
  • 61 (a)
OneToMany
ppp1r13bb 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18375 37
  • 60 (a)
ASPP 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ape-1 36
  • 27 (a)
ManyToMany
mel-11 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for PPP1R13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R13B Gene

ENSEMBL:
Gene Tree for PPP1R13B (if available)
TreeFam:
Gene Tree for PPP1R13B (if available)

Paralogs for PPP1R13B Gene

Paralogs for PPP1R13B Gene

Selected SIMAP similar genes for PPP1R13B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PPP1R13B: view

Variants for PPP1R13B Gene

Sequence variations from dbSNP and Humsavar for PPP1R13B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs722637 -- 103,795,386(-) GCTTT(G/T)GTACA intron-variant
rs730114 -- 103,739,474(-) GGTCA(G/T)TGTTG intron-variant
rs876002 -- 103,773,360(+) ccaga(A/G)ctgtt intron-variant
rs879724 -- 103,774,438(-) atgtc(C/T)ccagg intron-variant
rs941473 -- 103,735,532(-) GGCTT(C/G)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R13B Gene

Variant ID Type Subtype PubMed ID
nsv902300 CNV Loss 21882294
nsv902308 CNV Loss 21882294
dgv1995n71 CNV Loss 21882294
dgv658e1 CNV Complex 17122850
nsv470673 CNV Loss 18288195
nsv902313 CNV Loss 21882294
nsv9172 CNV Gain 18304495
nsv902318 CNV Loss 21882294
nsv902319 CNV Gain 21882294
nsv902320 CNV Gain 21882294
nsv902321 CNV Loss 21882294
esv24784 CNV Loss 19812545

Relevant External Links for PPP1R13B Gene

HapMap Linkage Disequilibrium report
PPP1R13B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R13B Gene

Disorders for PPP1R13B Gene

(1) Novoseek inferred disease relationships for PPP1R13B Gene

Disease -log(P) Hits PubMed IDs
tumors 0 5

Relevant External Links for PPP1R13B

Genetic Association Database (GAD)
PPP1R13B
Human Genome Epidemiology (HuGE) Navigator
PPP1R13B
genes like me logo Genes that share disorders with PPP1R13B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PPP1R13B Gene

Publications for PPP1R13B Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. ASPP proteins specifically stimulate the apoptotic function of p53. (PMID: 11684014) Samuels-Lev Y. … Lu X. (Mol. Cell 2001) 3 4
  3. Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma. (PMID: 20034025) Zhao J. … Guo Y. (Hepatology 2010) 3 23
  4. ASPP1 and ASPP2 are new transcriptional targets of E2F. (PMID: 15731768) Fogal V. … Lu X. (Cell Death Differ. 2005) 3 23
  5. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. (PMID: 15757645) Liu Z.J. … Xin H.M. (FEBS Lett. 2005) 3 23

Products for PPP1R13B Gene

Sources for PPP1R13B Gene

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