Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R13B Gene

protein-coding   GIFtS: 60
GCID: GC14M104200

Protein Phosphatase 1, Regulatory Subunit 13B

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 13B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory Subunit 13B1 2     Apoptosis-Stimulating Protein Of P53, 12
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 13B1 2     p53BP2-like2
Protein Phosphatase 1 Regulatory Subunit 13B2 3     p852
ASPP12 3     KIAA07713
Apoptosis-Stimulating Of P53 Protein 12     

External Ids:    HGNC: 149501   Entrez Gene: 233682   Ensembl: ENSG000000888087   OMIM: 6064555   UniProtKB: Q96KQ43   

Export aliases for PPP1R13B gene to outside databases

Previous GC identifers: GC14M101591 GC14M098015 GC14M102190 GC14M103271 GC14M084378


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R13B Gene:
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins.
The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP
proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and
transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is
regulated by the E2F transcription factor. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1R13B Gene: 
PPP1R13B (protein phosphatase 1, regulatory subunit 13B) is a protein-coding gene. Diseases associated with PPP1R13B include fanconi's anemia, and acute lymphoblastic leukemia, and among its related super-pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include protein binding. An important paralog of this gene is PPP1R16B.

UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53.
Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic
genes in vivo

Gene Wiki entry for PPP1R13B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R13B gene promoter:
         AREB6   c-Rel   AML1a   p53   MyoD   Nkx2-5   Ik-3   YY1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PPP1R13B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R13B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

PPP1R13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R13B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M104200:  view genomic region     (about GC identifiers)

Start:
104,200,088 bp from pter      End:
104,313,927 bp from pter
Size:
113,840 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4 (See protein sequence)
Recommended Name: Apoptosis-stimulating of p53 protein 1  
Size: 1090 amino acids; 119565 Da
Subunit: Interacts with TP53
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear
Miscellaneous: In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1.
This name was given due to its similarity with a protein that binds to protein phosphatase 1
Secondary accessions: B2RMX5 O94870

Explore the universe of human proteins at neXtProt for PPP1R13B: NX_Q96KQ4

Explore proteomics data for PPP1R13B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KQ4

  • PPP1R13B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP1R13B Protein Expression
    REFSEQ proteins: NP_056131.2  
    ENSEMBL proteins: 
     ENSP00000451433   ENSP00000202556   ENSP00000451739   ENSP00000451396   ENSP00000452376  
     ENSP00000450734   ENSP00000395213  

    Human Recombinant Protein Products for PPP1R13B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPP1R13B
    OriGene Protein Over-expression Lysate for PPP1R13B
    OriGene MassSpec for PPP1R13B 
    OriGene Custom Protein Services for PPP1R13B
    GenScript Custom Purified and Recombinant Proteins Services for PPP1R13B
    Novus Biologicals PPP1R13B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPP1R13B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS15782125
    GO:0005886plasma membrane IDA--

    PPP1R13B for ontologies           About GeneDecksing



    PPP1R13B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PPP1R13B
    GenScript Custom Superior Antibodies Services for PPP1R13B
    Novus Biologicals PPP1R13B Antibodies
    Abcam antibodies for PPP1R13B
    Cloud-Clone Corp. Antibodies for PPP1R13B 
    ThermoFisher Antibodies for PPP1R13B
    LSBio Antibodies in human, mouse, rat for PPP1R13B 

    Assay Products for PPP1R13B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP1R13B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP1R13B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPP1R13B 
    Cloud-Clone Corp. CLIAs for PPP1R13B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96KQ4

    ProtoNet protein and cluster: Q96KQ4

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Domain: The ankyrin repeats and the SH3 domain are required for specific interactions with TP53
    Similarity: Belongs to the ASPP family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 SH3 domain


    PPP1R13B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASPP1_HUMAN, Q96KQ4
    Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53.
    Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic
    genes in vivo

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11684014
         
    PPP1R13B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppp1r13b):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  integument 
     normal 

    PPP1R13B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP1R13B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP1R13B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R13B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1R13B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R13B
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R13B (see all 19):
    hsa-miR-2052 hsa-miR-539 hsa-miR-4288 hsa-miR-1914* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R13B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP1R13B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R13B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP1R13B
    Sirion Biotech Customized adenovirus for overexpression of PPP1R13B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PPP1R13B (see all 7)
    OriGene ORF clones in mouse, rat for PPP1R13B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP1R13B (NM_015316)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R13B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R13B
    Sirion Biotech Customized lentivirus for stable overexpression of PPP1R13B 
                         Customized lentivirus expression plasmids for stable overexpression of PPP1R13B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP1R13B
    Search LifeMap BioReagents cell lines for PPP1R13B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R13B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP1R13B About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    4Rho Family GTPases
    ERK Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R13B (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 BioSystems Pathway for PPP1R13B
        Direct p53 effectors


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R13B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for PPP1R13B (Q96KQ42, 3 ENSP000002025564) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP63Q9H3D42, 3, ENSP000002647314MINT-45876 MINT-45877 I2D: score=3 STRING: ENSP00000264731
    TP73O153502, 3, ENSP000003675454MINT-45878 MINT-45880 I2D: score=2 STRING: ENSP00000367545
    PPP1CAP621362, 3, ENSP000003260314MINT-62203 I2D: score=3 STRING: ENSP00000326031
    EP300Q094722, 3, ENSP000002632534MINT-8152513 MINT-8152577 I2D: score=1 STRING: ENSP00000263253
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045786negative regulation of cell cycle TAS14729977
    GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator IDA11684014

    PPP1R13B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R13B (ASPP1)

    Search CenterWatch for drugs/clinical trials and news about PPP1R13B / ASPP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP1R13B gene: 
    NM_015316.2  

    Unigene Cluster for PPP1R13B:

    Protein phosphatase 1, regulatory subunit 13B
    Hs.709297  [show with all ESTs]
    Unigene Representative Sequence: NM_015316
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557587 ENST00000202556(uc010awv.1 uc001yof.1) ENST00000555825
    ENST00000556597 ENST00000557082(uc001yog.1) ENST00000555391 ENST00000556334
    ENST00000554432 ENST00000556325 ENST00000555991 ENST00000557744 ENST00000555183
    ENST00000555708 ENST00000554106 ENST00000555734 ENST00000554136 ENST00000553739
    ENST00000423488
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R13B
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R13B (see all 19):
    hsa-miR-2052 hsa-miR-539 hsa-miR-4288 hsa-miR-1914* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R13B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP1R13B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R13B
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP1R13B (see all 7)
    OriGene ORF clones in mouse, rat for PPP1R13B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP1R13B (NM_015316)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R13B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R13B
    Sirion Biotech Customized lentivirus for stable overexpression of PPP1R13B 
                         Customized lentivirus expression plasmids for stable overexpression of PPP1R13B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1R13B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP1R13B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R13B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R13B

    Additional mRNA sequence: 

    AB018314.1 AJ318887.2 AK021580.1 AK023188.1 AK023301.1 AK307149.1 BC035446.1 BC047639.1 
    BC136527.1 

    18 DOTS entries:

    DT.212482  DT.422199  DT.95243376  DT.95082423  DT.99948224  DT.75102055  DT.75196652  DT.91698215 
    DT.91902607  DT.120749013  DT.120749053  DT.75152495  DT.120749072  DT.120749075  DT.40131916  DT.75102056 
    DT.120749009  DT.40224152 

    24/160 AceView cDNA sequences (see all 160):

    BC035446 Z42691 AA448143 AB018314 BM743679 BX395145 CR621089 H14282 
    CF139725 AK021580 BF001756 AI470226 BM788859 T09109 AL134693 BM825426 
    AU117852 AW295734 AK023188 CD243743 BQ917642 CK429908 AI262553 AI915996 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R13B (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                    -                       -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                       -     -                                                                                                         
    SP5:                                                                                                              -     -     -     -     -                 -   

    ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b
    SP1:                                                                                                                              
    SP2:                                                                                      -                 -                     
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:  -                                                                                                                           


    ECgene alternative splicing isoforms for PPP1R13B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R13B expression in normal human tissues (normalized intensities)      PPP1R13B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCTGCCA
    PPP1R13B Expression
    About this image


    PPP1R13B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             medial temporal gyrus   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See PPP1R13B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R13B

    SOURCE GeneReport for Unigene cluster: Hs.709297

    UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Tissue specificity: Reduced expression in breast carcinomas expressing a wild-type TP53 protein

        SABiosciences Expression via Pathway-Focused PCR Array including PPP1R13B: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1R13B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP1R13B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R13B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R13B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R13B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R13B gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r13b1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 85.99(n)1
    92.09(a)1
      12 (61.14 cM)5
    219811  NM_011625.11  NP_035755.11 
     1118284585 
    chicken
    (Gallus gallus)
    Aves PPP1R13B1 protein phosphatase 1, regulatory (inhibitor) subunit more 74.57(n)
    82.47(a)
      423487  XM_421392.3  XP_421392.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R13B6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    1(5946652-5996215)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114882 Xenopus laevis transcribed sequence with moderate similarity more 77.19(n)    BG364253.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3752 sbcb375 76.91(n)   321228  BQ615495.1 


    ENSEMBL Gene Tree for PPP1R13B (if available)
    TreeFam Gene Tree for PPP1R13B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R13B gene
    PPP1R16B2  PPP1R12B2  PPP1R12A2  TP53BP22  PPP1R16A2  PPP1R12C2  PPP1R13L2  
    5 SIMAP similar genes for PPP1R13B using alignment to 8 protein entries:     ASPP1_HUMAN (see all proteins):
    GRAP2    PPP1R12A    TP53BP2    PPP1R12B    PPP1R13L

    PPP1R13B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2404 SNPs in PPP1R13B are shown (see all 2404)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128151571,2
    C,F--84494598(+) TTCCCG/ACTGGT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs772367731,2
    --84494654(+) CATCAC/TCTCCC 1 -- us2k10--------
    rs124346861,2
    C,F,A,H--84494700(+) TCTAGT/CCTCCA 1 -- us2k110Minor allele frequency- C:0.44NA WA CSA EA 373
    rs71414731,2
    C,F,A,H--84494722(+) TTCCCC/AACACG 1 -- us2k110Minor allele frequency- A:0.45NA WA CSA EA 373
    rs1422024731,2
    --104200658(+) CCACCC/TCCAGC 1 -- ut310--------
    rs1908292351,2
    --104200763(+) GCAGCA/CTGACA 1 -- ut310--------
    rs751581971,2
    C,F--104200781(+) AGATCG/AGAGGA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1177813541,2
    C,F--104200836(+) GGGTCC/TTGGTG 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1828685171,2
    --104200845(+) TGCCCA/GTGGCG 1 -- ut310--------
    rs1872190681,2
    C--104200893(+) CCTTTA/GGGTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP1R13B (104200088 - 104313927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for PPP1R13B (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902321CNV Loss21882294
    nsv902308CNV Loss21882294
    nsv902313CNV Loss21882294
    nsv902318CNV Loss21882294
    dgv1995n71CNV Loss21882294
    nsv470673CNV Loss18288195
    esv24784CNV Loss19812545
    nsv902300CNV Loss21882294
    nsv902320CNV Gain21882294
    nsv9172CNV Gain18304495

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1R13B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R13B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606455    OMIM disorders: --

    12 diseases for PPP1R13B:    About MalaCards
    fanconi's anemia    acute lymphoblastic leukemia    lymphoblastic leukemia    anemia
    schizophrenia    hepatitis b    melanoma    hepatitis
    leukemia    lung cancer    breast cancer    prostatitis


    PPP1R13B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PPP1R13B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 9 20034025 (3), 15757645 (2)

    Genetic Association Database (GAD): PPP1R13B
    Human Genome Epidemiology (HuGE) Navigator: PPP1R13B (2 documents)

    Export disorders for PPP1R13B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R13B gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with PPP1R13B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Single-nucleotide polymorphisms in DNA-repair genes a nd cutaneous melanoma. (PubMed id 20601096)1, 4 Figl A....Kumar R. (2010)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    5. ASPP proteins specifically stimulate the apoptotic function of p53. (PubMed id 11684014)1, 2 Samuels-Lev Y.... Lu X. (2001)
    6. Epigenetic silence of ankyrin-repeat-containing, SH3- domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and AS PP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular ca rcinoma. (PubMed id 20034025)1, 9 Zhao J....Guo Y. (2010)
    7. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. (PubMed id 16314841)1, 9 Agirre X....Prosper F. (2006)
    8. ASPP1 and ASPP2 are new transcriptional targets of E2F. (PubMed id 15731768)1, 9 Fogal V....Lu X. (2005)
    9. Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. (PubMed id 15782125)1, 9 Bergamaschi D....Lu X. (2005)
    10. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. (PubMed id 15757645)1, 9 Liu Z.J....Xin H.M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23368 HGNC: 14950 AceView: PPP1R13B Ensembl:ENSG00000088808 euGenes: HUgn23368
    ECgene: PPP1R13B H-InvDB: PPP1R13B

    (According to HUGE)
    About This Section
    HUGE: KIAA0771

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R13B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R13B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1R13B gene:
    Search GeneIP for patents involving PPP1R13B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PPP1R13B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PPP1R13B  
     OriGene MassSpec something-or-other for PPP1R13B   OriGene clones in human, mouse for PPP1R13B  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP1R13B   OriGene Purified Protein for PPP1R13B  
     OriGene ORF clones in mouse, rat for PPP1R13B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP1R13B   OriGene Custom Protein Services for PPP1R13B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP1R13B
     QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R13B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R13B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R13B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R13B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R13B
     GenScript Custom Purified and Recombinant Proteins Services for PPP1R13B GenScript cDNA clones with any tag delivered in your preferred vector for PPP1R13B
     GenScript Custom Assay Services for PPP1R13B GenScript Custom Superior Antibodies Services for PPP1R13B
     GenScript Custom overexpressing Cell Line Services for PPP1R13B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PPP1R13B promoter
     Search Chromatin IP Primers for PPP1R13B
     RT2 qPCR Primer Assay in human, mouse, rat PPP1R13B
     GNC Network for PPP1R13B
     SABiosciences PCR Arrays including human, mouse, rat PPP1R13B
     Search Tocris compounds for PPP1R13B (ASPP1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPP1R13B antibodies
     PPP1R13B lysates
     Antibodies for PPP1R13B
     See all of Abcam's Antibodies, Kits and Proteins for PPP1R13B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PPP1R13B
     Antibodies for PPP1R13B
     ELISAs for PPP1R13B
     CLIAs for PPP1R13B
     Search LifeMap BioReagents cell lines for PPP1R13B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R13B
     SwitchGear 3'UTR luciferase reporter plasmids for PPP1R13B
     SwitchGear Promoter luciferase reporter plasmids for PPP1R13B
     ThermoFisher Antibodies for PPP1R13B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R13B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP1R13B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP1R13B
    Customized:
     lentivirus for stable overexpression of PPP1R13B
     lentivirus expression plasmids for stable overexpression of PPP1R13B
     adenovirus for overexpression of PPP1R13B
     LSBio Antibodies in human, mouse, rat for PPP1R13B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP1R13B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4