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PPP1R13B Gene

protein-coding   GIFtS: 57
GCID: GC14M104200

Protein Phosphatase 1, Regulatory Subunit 13B

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 13B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 13B1 2     Apoptosis-Stimulating Protein Of P53, 12
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 13B1 2     p53BP2-like2
Protein Phosphatase 1 Regulatory Subunit 13B2 3     p852
ASPP12 3     KIAA07713
Apoptosis-Stimulating Of P53 Protein 12     

External Ids:    HGNC: 149501   Entrez Gene: 233682   Ensembl: ENSG000000888087   OMIM: 6064555   UniProtKB: Q96KQ43   

Export aliases for PPP1R13B gene to outside databases

Previous GC identifers: GC14M101591 GC14M098015 GC14M102190 GC14M103271 GC14M084378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R13B Gene:
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins.
The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP
proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and
transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is
regulated by the E2F transcription factor. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1R13B Gene:
PPP1R13B (protein phosphatase 1, regulatory subunit 13B) is a protein-coding gene. An important paralog of this gene is PPP1R16B.

UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53.
Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic
genes in vivo

Gene Wiki entry for PPP1R13B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R13B gene promoter:
         AREB6   c-Rel   AML1a   p53   MyoD   Nkx2-5   Ik-3   YY1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PPP1R13B promoter sequence
   Search Chromatin IP Primers for PPP1R13B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

PPP1R13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R13B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M104200:  view genomic region     (about GC identifiers)

Start:
104,200,088 bp from pter      End:
104,313,927 bp from pter
Size:
113,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4 (See protein sequence)
Recommended Name: Apoptosis-stimulating of p53 protein 1  
Size: 1090 amino acids; 119565 Da
Subunit: Interacts with TP53
Miscellaneous: In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1.
This name was given due to its similarity with a protein that binds to protein phosphatase 1
Secondary accessions: B2RMX5 O94870

Explore the universe of human proteins at neXtProt for PPP1R13B: NX_Q96KQ4

Explore proteomics data for PPP1R13B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R13B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056131.2  
    ENSEMBL proteins: 
     ENSP00000451433   ENSP00000202556   ENSP00000451739   ENSP00000451396   ENSP00000452376  
     ENSP00000450734   ENSP00000395213  

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    Cloud-Clone Corp. Proteins for PPP1R13B

     
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    ThermoFisher Antibodies for PPP1R13B
    LSBio Antibodies in human, mouse, rat for PPP1R13B

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    Search eBioscience for ELISAs for PPP1R13B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    4 InterPro protein domains:
     IPR001452 SH3_domain
     IPR002110 Ankyrin_rpt
     IPR028319 ASPP_1
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96KQ4

    ProtoNet protein and cluster: Q96KQ4

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Domain: The ankyrin repeats and the SH3 domain are required for specific interactions with TP53
    Similarity: Belongs to the ASPP family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with PPP1R13B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASPP1_HUMAN, Q96KQ4
    Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53.
    Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic
    genes in vivo

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11684014
    GO:0008134transcription factor binding IEA--
         
    Find genes that share ontologies with PPP1R13B           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppp1r13b):
     cardiovascular system  growth/size/body  homeostasis/metabolism  immune system  integument 
     normal 

    Find genes that share phenotypes with PPP1R13B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1R13B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1R13B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1R13B

    miRNA
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    miRTarBase miRNAs that target PPP1R13B:
    hsa-mir-29b-3p (MIRT006486), hsa-mir-766-3p (MIRT039041), hsa-mir-93-3p (MIRT038764), hsa-mir-29c-3p (MIRT006487), hsa-mir-29a-3p (MIRT006485), hsa-mir-505-3p (MIRT040984), hsa-mir-138-5p (MIRT045828), hsa-mir-421 (MIRT039385), hsa-mir-10b-5p (MIRT047417)

    Block miRNA regulation of human, mouse, rat PPP1R13B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1R13B (see all 19):
    hsa-miR-2052 hsa-miR-539 hsa-miR-4288 hsa-miR-1914* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R13B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1R13B

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    GenScript: all cDNA clones in your preferred vector: PPP1R13B (NM_015316)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R13B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASPP1_HUMAN, Q96KQ4: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS15782125
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with PPP1R13B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R13B About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    4ERK Signaling
    ERK Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R13B (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 BioSystems Pathway for PPP1R13B
        Direct p53 effectors


        Pathway & Disease-focused RT2 Profiler PCR Array including PPP1R13B: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP1R13B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for PPP1R13B (Q96KQ41, 2, 3 ENSP000002025564) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621361, 2, 3, ENSP000003260314EBI-1105153,EBI-357253 MINT-62203 I2D: score=3 STRING: ENSP00000326031
    TP63Q9H3D42, 3, ENSP000002647314MINT-45876 MINT-45877 I2D: score=3 STRING: ENSP00000264731
    TP73O153502, 3, ENSP000003675454MINT-45878 MINT-45880 I2D: score=2 STRING: ENSP00000367545
    EP300Q094721, 2, 3, ENSP000002632534EBI-1105153,EBI-447295 MINT-8152513 MINT-8152577 I2D: score=1 STRING: ENSP00000263253
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0045786negative regulation of cell cycle TAS14729977
    GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator IDA11684014

    Find genes that share ontologies with PPP1R13B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R13B (ASPP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1R13B gene: 
    NM_015316.2  

    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557587 ENST00000202556(uc010awv.1 uc001yof.1) ENST00000555825
    ENST00000556597 ENST00000557082(uc001yog.1) ENST00000555391 ENST00000556334
    ENST00000554432 ENST00000556325 ENST00000555991 ENST00000557744 ENST00000555183
    ENST00000555708 ENST00000554106 ENST00000555734 ENST00000554136 ENST00000553739
    ENST00000423488
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    Selected qRT-PCR Assays for microRNAs that regulate PPP1R13B (see all 19):
    hsa-miR-2052 hsa-miR-539 hsa-miR-4288 hsa-miR-1914* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R13B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP1R13B
      QuantiFast Probe-based Assays in human, mouse, rat PPP1R13B

    Selected AceView cDNA sequences (see all 160):

    BF001756 AA431274 AK021580 AL134693 BM743679 AI470226 Z39992 AI262553 
    AW295734 BM825426 BI766885 AK023188 BM673177 BM788859 T09109 AI915996 
    AA448143 CR621089 BC035446 BC047639 BQ917642 CD243743 BM699786 BX395145 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R13B (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                    -                       -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                       -     -                                                                                                         
    SP5:                                                                                                              -     -     -     -     -                 -   

    ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b
    SP1:                                                                                                                              
    SP2:                                                                                      -                 -                     
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:  -                                                                                                                           


    ECgene alternative splicing isoforms for PPP1R13B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPP1R13B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCTGCCA
    PPP1R13B Expression
    About this image


    PPP1R13B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PPP1R13B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R13B Protein Expression

    UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Tissue specificity: Reduced expression in breast carcinomas expressing a wild-type TP53 protein

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP1R13B: 
              Apoptosis 384HT in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1R13B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R13B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R13B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r13b1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 86.05(n)1
    92.09(a)1
      12 (61.14 cM)5
    219811  NM_011625.11  NP_035755.11 
     1118284585 
    chicken
    (Gallus gallus)
    Aves PPP1R13B1 protein phosphatase 1, regulatory (inhibitor) subunit more 74.41(n)
    82.22(a)
      423487  XM_004936380.1  XP_004936437.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R13B6
    protein phosphatase 1, regulatory subunit 13B
    73(a)
    1 ↔ 1
    1(5946652-5996215)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114882 Xenopus laevis transcribed sequence with moderate similarity more 77.19(n)    BG364253.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3752 sbcb375 76.91(n)   321228  BQ615495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG183753   -- 60(a)   57D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea ape-16
    mel-116
    Protein APE-1, isoform a
    Protein MEL-11, isoform c (mel-11) mRNA, complete ...
    27(a)
    13(a)
    many ↔ many
    many ↔ many
    V(11675942-11685277) WBGene00000146
    II(9358531-9369087) WBGene00003196


    ENSEMBL Gene Tree for PPP1R13B (if available)
    TreeFam Gene Tree for PPP1R13B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R13B gene
    PPP1R16B2  PPP1R12B2  PPP1R12A2  TP53BP22  PPP1R16A2  PPP1R12C2  PPP1R13L2  
    5 SIMAP similar genes for PPP1R13B using alignment to 8 protein entries:     ASPP1_HUMAN (see all proteins):
    GRAP2    PPP1R12A    TP53BP2    PPP1R12B    PPP1R13L

    Find genes that share paralogs with PPP1R13B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R13B (see all 2404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128151571,2
    C,F--84494598(+) TTCCCG/ACTGGT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs772367731,2
    --84494654(+) CATCAC/TCTCCC 1 -- us2k10--------
    rs124346861,2
    C,F,A,H--84494700(+) TCTAGT/CCTCCA 1 -- us2k110Minor allele frequency- C:0.44NA WA CSA EA 373
    rs71414731,2
    C,F,A,H--84494722(+) TTCCCC/AACACG 1 -- us2k110Minor allele frequency- A:0.45NA WA CSA EA 373
    rs1422024731,2
    --104200658(+) CCACCC/TCCAGC 1 -- ut310--------
    rs1908292351,2
    --104200763(+) GCAGCA/CTGACA 1 -- ut310--------
    rs751581971,2
    C,F--104200781(+) AGATCG/AGAGGA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1177813541,2
    C,F--104200836(+) GGGTCC/TTGGTG 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1828685171,2
    --104200845(+) TGCCCA/GTGGCG 1 -- ut310--------
    rs1872190681,2
    C--104200893(+) CCTTTA/GGGTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP1R13B (104200088 - 104313927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPP1R13B (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902321CNV Loss21882294
    nsv902308CNV Loss21882294
    nsv902313CNV Loss21882294
    nsv902318CNV Loss21882294
    dgv1995n71CNV Loss21882294
    nsv470673CNV Loss18288195
    esv24784CNV Loss19812545
    nsv902300CNV Loss21882294
    nsv902320CNV Gain21882294
    nsv9172CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1R13B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R13B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606455    OMIM disorders: --


    Find genes that share disorders with PPP1R13B           About GenesLikeMe

    1 Novoseek inferred disease relationship for PPP1R13B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 9 20034025 (3), 15757645 (2)

    Genetic Association Database (GAD): PPP1R13B
    Human Genome Epidemiology (HuGE) Navigator: PPP1R13B (2 documents)

    Export disorders for PPP1R13B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R13B gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with PPP1R13B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma. (PubMed id 20601096)1, 4 Figl A....Kumar R. (Mutat. Res. 2010)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    5. ASPP proteins specifically stimulate the apoptotic function of p53. (PubMed id 11684014)1, 2 Samuels-Lev Y.... Lu X. (Mol. Cell 2001)
    6. Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma. (PubMed id 20034025)1, 9 Zhao J....Guo Y. (Hepatology 2010)
    7. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. (PubMed id 16314841)1, 9 Agirre X....PrA^sper F. (Oncogene 2006)
    8. ASPP1 and ASPP2 are new transcriptional targets of E2F. (PubMed id 15731768)1, 9 Fogal V....Lu X. (Cell Death Differ. 2005)
    9. Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. (PubMed id 15782125)1, 9 Bergamaschi D....Lu X. (Oncogene 2005)
    10. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. (PubMed id 15757645)1, 9 Liu Z.J....Xin H.M. (FEBS Lett. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23368 HGNC: 14950 AceView: PPP1R13B Ensembl:ENSG00000088808 euGenes: HUgn23368
    ECgene: PPP1R13B H-InvDB: PPP1R13B

    (According to HUGE)
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    HUGE: KIAA0771

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R13B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R13B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R13B gene:
    Search GeneIP for patents involving PPP1R13B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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