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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R13B Gene

protein-coding   GIFtS: 57
GCID: GC14M104200

protein phosphatase 1, regulatory subunit 13B

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 13B...)
 Explore 13 diseases affiliated with
PPP1R13B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPP1R13B    

Aliases
for PPP1R13B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase 1, Regulatory Subunit 13B1 2     KIAA07711 3
ASPP11 2 3     Protein Phosphatase 1 Regulatory Subunit 13B2 3
P53BP2-Like1     Apoptosis-Stimulating Of P53 Protein 12
P851     Apoptosis-Stimulating Protein Of P53, 12
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 13B1 2     

External Ids:    HGNC: 149501   Entrez Gene: 233682   Ensembl: ENSG000000888087   OMIM: 6064555   UniProtKB: Q96KQ43   

Export aliases for PPP1R13B gene to outside databases

Previous GC identifers: GC14M101591 GC14M098015 GC14M102190 GC14M103271 GC14M084378


Summaries
for PPP1R13B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPP1R13B:
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The
protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are
required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of
p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F
transcription factor. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates
TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo

Gene Wiki entry for PPP1R13B


Genomic Views
for PPP1R13B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R13B gene promoter:
         AREB6   c-Rel   AML1a   p53   MyoD   Nkx2-5   Ik-3   YY1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PPP1R13B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R13B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

PPP1R13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R13B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M104200:  view genomic region     (about GC identifiers)

Start:
 104,200,088 bp from pter      End:
 104,313,927 bp from pter
Size:
 113,840 bases      Orientation:
 minus strand

Proteins
for PPP1R13B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4 (See protein sequence)
Recommended Name: Apoptosis-stimulating of p53 protein 1  
Size: 1090 amino acids; 119565 Da
Subunit: Interacts with TP53
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear
Miscellaneous: In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This
name was given due to its similarity with a protein that binds to protein phosphatase 1
Secondary accessions: B2RMX5 O94870

Explore the universe of human proteins at neXtProt for PPP1R13B: NX_Q96KQ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96KQ4

    • PPP1R13B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056131.2  
    ENSEMBL proteins: 
     ENSP00000451433   ENSP00000202556   ENSP00000451739   ENSP00000451396   ENSP00000452376  
     ENSP00000450734   ENSP00000395213  

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    Novus Biologicals PPP1R13B Lysate
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    Uscn Proteins for PPP1R13B

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS15782125
    GO:0005886plasma membrane IDA--


    PPP1R13B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PPP1R13B

    Protein Domains /
    Families
    for PPP1R13B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPP1R13B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001452 SH3_domain
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96KQ4

    ProtoNet protein and cluster: Q96KQ4

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Domain: The ankyrin repeats and the SH3 domain are required for specific interactions with TP53
    Similarity: Belongs to the ASPP family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 SH3 domain


    Function
    for PPP1R13B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates
    TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo

    miRNA
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    hsa-miR-2052 hsa-miR-539 hsa-miR-4288 hsa-miR-1914* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: PPP1R13B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R13B (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14729977


    PPP1R13B for ontologies           About GeneDecksing


    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ppp1r13b):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  integument 
     normal 

    PPP1R13B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPP1R13B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Erythropoietin Pathway
    		Erythropoietin Pathway1.00
    		Insulin Receptor Pathway0.37
    		Beta-Adrenergic Signaling0.37
    		CDK5 Pathway0.21
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    4Direct p53 effectors
    		Direct p53 effectors1.00
    5PEDF Induced Signaling
    		IL-6 Pathway0.61

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R13B (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 BioSystems Pathway for PPP1R13B 
        Direct p53 effectors


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R13B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for PPP1R13B (Q96KQ42, 3 ENSP000002025564) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP63Q9H3D42, 3, ENSP000002647314MINT-45876 MINT-45877 I2D: score=3 STRING: ENSP00000264731
    TP73O153502, 3, ENSP000003675454MINT-45878 MINT-45880 I2D: score=2 STRING: ENSP00000367545
    PPP1CAP621362, 3, ENSP000003260314MINT-62203 I2D: score=3 STRING: ENSP00000326031
    EP300Q094722, 3, ENSP000002632534MINT-8152513 MINT-8152577 I2D: score=1 STRING: ENSP00000263253
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis IDA11684014
    GO:0045786negative regulation of cell cycle TAS14729977


    PPP1R13B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPP1R13B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PPP1R13B
    Search CenterWatch for drugs/clinical trials and news about PPP1R13B / ASPP1 

    Transcripts
    for PPP1R13B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPP1R13B gene: 
    NM_015316.2  

    Unigene Cluster for PPP1R13B:

    Protein phosphatase 1, regulatory subunit 13B
    Hs.709297  [show with all ESTs]
    Unigene Representative Sequence: NM_015316
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557587 ENST00000202556(uc010awv.1 uc001yof.1) ENST00000555825
    ENST00000556597 ENST00000557082(uc001yog.1) ENST00000555391 ENST00000556334
    ENST00000554432 ENST00000556325 ENST00000555991 ENST00000557744 ENST00000555183
    ENST00000555708 ENST00000554106 ENST00000555734 ENST00000554136 ENST00000553739
    ENST00000423488

    miRNA
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    hsa-miR-2052 hsa-miR-539 hsa-miR-4288 hsa-miR-1914* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: PPP1R13B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R13B (see all 7)
    OriGene shRNA RFP: PPP1R13B
    OriGene siRNA: PPP1R13B
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    Clone
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    Additional cDNA sequence: 

    AB018314.1 AJ318887.2 AK021580.1 AK023188.1 AK023301.1 AK307149.1 BC035446.1 BC047639.1 
    BC136527.1 

    18 DOTS entries:

    DT.212482  DT.422199  DT.95243376  DT.95082423  DT.99948224  DT.75102055  DT.75196652  DT.91698215 
    DT.91902607  DT.120749013  DT.120749053  DT.75152495  DT.120749072  DT.120749075  DT.40131916  DT.75102056 
    DT.120749009  DT.40224152 

    24/160 AceView cDNA sequences (see all 160):

    AA448143 BM699786 BF001756 BX395145 AB018314 T09109 AI262553 BC047639 
    Z42691 AW295734 AK023188 AA431274 BI766885 BQ917642 AI915996 CF139725 
    BM825426 BM788859 AU117852 AK021580 H14282 CR621089 BM673177 AI470226 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R13B (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                    -                       -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                       -     -                                                                                                         
    SP5:                                                                                                              -     -     -     -     -                 -   

    ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b
    SP1:                                                                                                                              
    SP2:                                                                                      -                 -                     
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:  -                                                                                                                           


    ECgene alternative splicing isoforms for PPP1R13B

    Expression
    for PPP1R13B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R13B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCGCTGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPP1R13B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPP1R13B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R13B

    SOURCE GeneReport for Unigene cluster: Hs.709297

    UniProtKB/Swiss-Prot: ASPP1_HUMAN, Q96KQ4
    Tissue specificity: Reduced expression in breast carcinomas expressing a wild-type TP53 protein

        SABiosciences Expression via Pathway-Focused PCR Array including PPP1R13B: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Orthologs
    for PPP1R13B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R13B gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PPP1R13B1 protein phosphatase 1, regulatory (inhibitor) subunit more 74.57(n)
    82.47(a)    		   423487  XM_421392.3  XP_421392.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PPP1R13B6
    		 --
    		 68(a)
    		 1 ↔ 1
    		 1(5946652-5996215)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.114882 Xenopus laevis transcribed sequence with moderate similarity more 77.19(n)    BG364253.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb3752 sbcb375 76.91(n)   321228  BQ615495.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG183753   -- 60(a)   57D2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea mel-116
    		 Maternal Effect Lethal family member (mel-11)
    		 6(a)
    		 possible ortholog
    		 II(9358472-9369040)


    ENSEMBL Gene Tree for PPP1R13B (if available)
    TreeFam Gene Tree for PPP1R13B (if available) 

    Paralogs
    for PPP1R13B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R13B gene
    PPP1R16B2  PPP1R272  TP53BP22  PPP1R12A2  PPP1R16A2  PPP1R12B2  NRARP2  PPP1R12C2  
    PPP1R13L2  
    5 SIMAP similar genes for PPP1R13B using alignment to 8 protein entries:     ASPP1_HUMAN (see all proteins):
    GRAP2    PPP1R12A    TP53BP2    PPP1R12B    PPP1R13L

    PPP1R13B for paralogs           About GeneDecksing



    Genomic Variants
    for PPP1R13B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2003 NCBI SNPs in PPP1R13B are shown (see all 2003)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1128151571,2
    		--84494598(+) TTCCCG/ACTGGT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs772367731,2
    		--84494654(+) CATCAC/TCTCCC 1 -- us2k10--------
    rs1125028381,2
    		C,--104199591(+) TAATTG/-GGGGT 3 -- ut31 ds50011Minor allele frequency- -:0.50CSA 2
    rs1493776391,2
    		--104199645(+) ATATAC/TACCAT 3 -- ut31 ds50010--------
    rs1117302221,2
    		--104199663(+) AGTTCG/ACAGGT 3 -- ds5001 ut311Minor allele frequency- A:0.50CSA 2
    rs1809077181,2
    		--104199966(+) TTTGTA/GTATAA 3 -- ut31 ds50010--------
    rs1399688351,2
    		--104200035(+) GATCAC/TCTGAA 3 -- int1 ds50010--------
    rs1453804101,2
    		--104200157(+) GCCATA/GCTCCT 3 -- int1 ut310--------
    rs1142194031,2
    		C,F,--104200265(+) CTGTAC/TACACA 3 -- int1 ut311Minor allele frequency- T:0.04WA 118
    rs26171,2
    		C,F,--104200308(+) AAAAAA/C/TAGAGC 4 -- int1 ut311MN 184

    HapMap Linkage Disequilibrium report for PPP1R13B (104200088 - 104313927 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PPP1R13B
         3 CNVs: 71974 30664 3949

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    Disorders / Diseases
    for PPP1R13B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPP1R13B for disorders           About GeneDecksing

    OMIM gene information: 606455    OMIM disorders: --

    13 diseases for PPP1R13B:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    fanconi's anemia    hepatitis b
    anemia    breast carcinoma    leukemia    breast cancer
    hepatitis    schizophrenia    melanoma    carcinoma
    prostatitis

    1 Novoseek disease relationship for PPP1R13B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 9 20034025 (3), 15757645 (2)

    Human Genome Epidemiology (HuGE) Navigator: PPP1R13B (2 documents)

    Export disorders for PPP1R13B gene to outside databases

    Publications
    for PPP1R13B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R13B gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with PPP1R13B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    3. ASPP proteins specifically stimulate the apoptotic function of p53. (PubMed id 11684014)1, 2 Samuels-Lev Y.... Lu X. (2001)
    4. Epigenetic silence of ankyrin-repeat-containing, SH3- domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and AS PP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular ca rcinoma. (PubMed id 20034025)1, 9 Zhao J....Guo Y. (2010)
    5. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. (PubMed id 16314841)1, 9 Agirre X....Prosper F. (2006)
    6. ASPP1 and ASPP2 are new transcriptional targets of E2F. (PubMed id 15731768)1, 9 Fogal V....Lu X. (2005)
    7. Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. (PubMed id 15782125)1, 9 Bergamaschi D....Lu X. (2005)
    8. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. (PubMed id 15757645)1, 9 Liu Z.J....Xin H.M. (2005)
    9. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    10. An indirect role for ASPP1 in limiting p53-dependent p 21 expression and cellular senescence. (PubMed id 22068052)1 Vigneron A.M. and Vousden K.H. (2012)

    External Searches for PPP1R13B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPP1R13B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23368 HGNC: 14950 AceView: PPP1R13B Ensembl:ENSG00000088808 euGenes: HUgn23368
    ECgene: PPP1R13B H-InvDB: PPP1R13B

    Other Databases showing PPP1R13B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0771

    Specialized Databases showing PPP1R13B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R13B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R13B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PPP1R13B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPP1R13B gene:
    Search GeneIP for patents involving PPP1R13B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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