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Aliases for PPP1R12C Gene

Aliases for PPP1R12C Gene

  • Protein Phosphatase 1, Regulatory Subunit 12C 2 3
  • MBS85 3 4 6
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12C 2 3
  • Protein Phosphatase 1 Myosin-Binding Subunit Of 85 KDa 3 4
  • Protein Phosphatase 1 Myosin-Binding Subunit P85 3 4
  • Leukocyte Receptor Cluster (LRC) Member 3 2 3
  • Myosin-Binding Subunit 85 2 3
  • LENG3 3 4
  • Leukocyte Receptor Cluster (LRC) Encoded Novel Gene 3 3
  • Protein Phosphatase 1 Regulatory Subunit 12C 3
  • P85 3
  • P84 3

External Ids for PPP1R12C Gene

Previous Symbols for PPP1R12C Gene

  • LENG3

Summaries for PPP1R12C Gene

Entrez Gene Summary for PPP1R12C Gene

  • The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for PPP1R12C Gene

PPP1R12C (Protein Phosphatase 1, Regulatory Subunit 12C) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer and Regulation of actin cytoskeleton. An important paralog of this gene is PPP1R16A.

UniProtKB/Swiss-Prot for PPP1R12C Gene

  • Regulates myosin phosphatase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R12C Gene

Genomics for PPP1R12C Gene

Genomic Location for PPP1R12C Gene

Start:
55,090,913 bp from pter
End:
55,117,600 bp from pter
Size:
26,688 bases
Orientation:
Minus strand

Genomic View for PPP1R12C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R12C Gene

Regulatory Elements for PPP1R12C Gene

Proteins for PPP1R12C Gene

  • Protein details for PPP1R12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL4-PP12C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 12C
    Protein Accession:
    Q9BZL4
    Secondary Accessions:
    • B4DME2
    • Q59FK8
    • Q6ZPD1
    • Q7L8F7
    • Q96HW1
    • Q9H5H5
    • Q9NT00

    Protein attributes for PPP1R12C Gene

    Size:
    782 amino acids
    Molecular mass:
    84881 Da
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.
    SequenceCaution:
    • Sequence=AF211968; Type=Miscellaneous discrepancy; Note=Unspliced mRNA.; Evidence={ECO:0000305}; Sequence=BAB15651.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85179.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R12C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R12C Gene

Proteomics data for PPP1R12C Gene at MOPED

Post-translational modifications for PPP1R12C Gene

  • Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R12C Gene

No data available for DME Specific Peptides for PPP1R12C Gene

Domains for PPP1R12C Gene

Gene Families for PPP1R12C Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R12C Gene

UniProtKB/Swiss-Prot:

PP12C_HUMAN
Similarity:
  • Contains 4 ANK repeats.:
    • Q9BZL4
genes like me logo Genes that share domains with PPP1R12C: view

Function for PPP1R12C Gene

Molecular function for PPP1R12C Gene

UniProtKB/Swiss-Prot Function: Regulates myosin phosphatase activity.

Gene Ontology (GO) - Molecular Function for PPP1R12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with PPP1R12C: view

Phenotypes for PPP1R12C Gene

GenomeRNAi human phenotypes for PPP1R12C:
genes like me logo Genes that share phenotypes with PPP1R12C: view

miRNA for PPP1R12C Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1R12C Gene

Localization for PPP1R12C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R12C Gene

Cytoplasm. Note=Along actomyosin filaments and stress fibers. {ECO:0000269 PubMed:11399775, ECO:0000269 PubMed:12923170}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R12C Gene COMPARTMENTS Subcellular localization image for PPP1R12C gene
Compartment Confidence
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPP1R12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R12C: view

Pathways for PPP1R12C Gene

genes like me logo Genes that share pathways with PPP1R12C: view

Gene Ontology (GO) - Biological Process for PPP1R12C Gene

None

Transcripts for PPP1R12C Gene

Unigene Clusters for PPP1R12C Gene

Protein phosphatase 1, regulatory subunit 12C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1:
SP2:
SP3: - - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PPP1R12C Gene

GeneLoc Exon Structure for
PPP1R12C
ECgene alternative splicing isoforms for
PPP1R12C

Expression for PPP1R12C Gene

mRNA expression in normal human tissues for PPP1R12C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R12C Gene

SOURCE GeneReport for Unigene cluster for PPP1R12C Gene Hs.631579

mRNA Expression by UniProt/SwissProt for PPP1R12C Gene

Q9BZL4-PP12C_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart.
genes like me logo Genes that share expressions with PPP1R12C: view

Orthologs for PPP1R12C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R12C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R12C 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R12C 36
  • 86.82 (n)
  • 91.15 (a)
PPP1R12C 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R12C 36
  • 85.79 (n)
  • 90.03 (a)
PPP1R12C 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r12c 36
  • 83.78 (n)
  • 87.7 (a)
Ppp1r12c 16
Ppp1r12c 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R12C 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r12c 36
  • 83.09 (n)
  • 87.82 (a)
lizard
(Anolis carolinensis)
Reptilia PPP1R12C 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16736 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r12c 36
  • 55.95 (n)
  • 59.03 (a)
Str.15086 36
zebrafish
(Danio rerio)
Actinopterygii ppp1r12c 36
  • 55.88 (n)
  • 53.42 (a)
ppp1r12c 37
  • 47 (a)
OneToOne
Species with no ortholog for PPP1R12C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R12C Gene

ENSEMBL:
Gene Tree for PPP1R12C (if available)
TreeFam:
Gene Tree for PPP1R12C (if available)

Paralogs for PPP1R12C Gene

Paralogs for PPP1R12C Gene

Selected SIMAP similar genes for PPP1R12C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPP1R12C: view

Variants for PPP1R12C Gene

Sequence variations from dbSNP and Humsavar for PPP1R12C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs575144 -- 55,114,576(+) TTCAG(C/T)GCTAA intron-variant
rs604216 -- 55,112,438(+) TCCCC(C/T)ACCCC intron-variant
rs667451 -- 55,115,458(+) CAGAC(A/G)GCCGC intron-variant
rs679807 -- 55,108,387(+) acttt(A/G)ggagg intron-variant
rs682884 -- 55,114,327(+) CCCCC(C/T)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R12C Gene

Variant ID Type Subtype PubMed ID
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv912446 CNV Loss 21882294
dgv1131e1 CNV Complex 17122850
esv34356 CNV Gain 17911159
nsv817874 CNV Loss 17921354
dgv4015n71 CNV Loss 21882294
nsv912451 CNV Loss 21882294
nsv512597 CNV Loss 21212237
esv2718946 CNV Deletion 23290073
esv27516 CNV Loss 19812545
esv2718947 CNV Deletion 23290073
esv2676610 CNV Deletion 23128226
esv2718948 CNV Deletion 23290073
esv1366716 CNV Deletion 17803354
esv2718949 CNV Deletion 23290073
dgv581e201 CNV Deletion 23290073
nsv138336 CNV Loss 16902084
esv2718953 CNV Deletion 23290073
esv1010486 CNV Deletion 20482838
esv1104675 CNV Deletion 17803354

Relevant External Links for PPP1R12C Gene

HapMap Linkage Disequilibrium report
PPP1R12C

Disorders for PPP1R12C Gene

No disorders were found for PPP1R12C Gene.

No data available for UniProtKB/Swiss-Prot for PPP1R12C Gene

Publications for PPP1R12C Gene

  1. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I. … Leung T. (J. Biol. Chem. 2001) 2 3 4
  2. PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. (PMID: 12923170) Bannert N. … Kurth R. (J. Biol. Chem. 2003) 3 4
  3. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PMID: 14506264) Surks H.K. … Mendelsohn M.E. (J. Biol. Chem. 2003) 3
  4. p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis. (PMID: 15469989) Mulder J. … Moolenaar W.H. (Mol. Biol. Cell 2004) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for PPP1R12C Gene

  • antibodies-online proteins for PPP1R12C
  • antibodies-online antibodies for PPP1R12C
  • antibodies-online kits for PPP1R12C

Sources for PPP1R12C Gene

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