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PPP1R12C Gene

protein-coding   GIFtS: 53
GCID: GC19M055602

Protein Phosphatase 1, Regulatory Subunit 12C

(Previous names: leukocyte receptor cluster (LRC) member 3, protein phosphatase...)
(Previous symbol: LENG3)
  Search for PPP1R12C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 12C1 2     Protein Phosphatase 1 Myosin-Binding Subunit Of 85 KDa2 3
LENG31 2 3     Protein Phosphatase 1 Myosin-Binding Subunit P852 3
MBS852 3 5     Leukocyte Receptor Cluster (LRC) Encoded Novel Gene 32
Leukocyte Receptor Cluster (LRC) Member 31 2     p842
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12C1 2     p852
Myosin-Binding Subunit 851 2     Protein Phosphatase 1 Regulatory Subunit 12C2

External Ids:    HGNC: 149471   Entrez Gene: 547762   Ensembl: ENSG000001255037   OMIM: 6132455   UniProtKB: Q9BZL43   

Export aliases for PPP1R12C gene to outside databases

Previous GC identifers: GC19M056464 GC19M056026 GC19M060278 GC19M060294 GC19M051925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R12C Gene:
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein
phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Oct 2012)

GeneCards Summary for PPP1R12C Gene:
PPP1R12C (protein phosphatase 1, regulatory subunit 12C) is a protein-coding gene. An important paralog of this gene is PPP1R13B.

UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4
Function: Regulates myosin phosphatase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R12C gene promoter:
         p53   Tal-1   AML1a   STAT5A   RelA   NF-kappaB   E47   NF-kappaB1   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R12C promoter sequence
   Search Chromatin IP Primers for PPP1R12C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R12C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

PPP1R12C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R12C gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055602:  view genomic region     (about GC identifiers)

Start:
55,602,281 bp from pter      End:
55,628,927 bp from pter
Size:
26,647 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 12C  
Size: 782 amino acids; 84881 Da
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory
subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16.
Interacts with the coiled-coil domain of MPRIP
Caution: Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by
itself and is a part of the PPP1R12C gene
Sequence caution: Sequence=AF211968; Type=Miscellaneous discrepancy; Note=Unspliced mRNA; Sequence=BAB15651.1;
Type=Erroneous initiation; Sequence=BAC85179.1; Type=Erroneous initiation;
Secondary accessions: Q59FK8 Q6ZPD1 Q7L8F7 Q96HW1 Q9H5H5 Q9NT00
Alternative splicing: 4 isoforms:  Q9BZL4-1   Q9BZL4-2   Q9BZL4-3   Q9BZL4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP1R12C: NX_Q9BZL4

Explore proteomics data for PPP1R12C at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-560 is essential for its interaction with PPP1CB1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R12C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258547.1  NP_060077.1  

    ENSEMBL proteins: 
     ENSP00000263433   ENSP00000468148   ENSP00000387833   ENSP00000465957   ENSP00000365573  

    PPP1R12C Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR017401 Pase-1_reg_su_12A/B/C_euk
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BZL4

    ProtoNet protein and cluster: Q9BZL4

    UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with PPP1R12C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP12C_HUMAN, Q9BZL4
    Function: Regulates myosin phosphatase activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with PPP1R12C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP1R12C:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1R12C
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    miRNA
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    miRTarBase miRNAs that target PPP1R12C:
    hsa-mir-32-5p (MIRT028373), hsa-mir-103a-3p (MIRT027085), hsa-mir-130b-5p (MIRT038336), hsa-let-7b-5p (MIRT051961), hsa-mir-125b-2-3p (MIRT038627)

    Block miRNA regulation of human, mouse, rat PPP1R12C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1R12C (see all 32):
    hsa-miR-1224-3p hsa-miR-25 hsa-miR-218 hsa-miR-629* hsa-miR-92b hsa-miR-92a hsa-miR-32 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R12C 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R12C
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    Addgene plasmids for PPP1R12C 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R12C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP12C_HUMAN, Q9BZL4: Cytoplasm. Note=Along actomyosin filaments and stress fibers
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PPP1R12C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R12C About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    Vascular smooth muscle contraction0.32
    4Focal adhesion
    Focal adhesion0.65
    5PEDF Induced Signaling
    IL-6 Pathway0.61


    Find genes that share SuperPaths with PPP1R12C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R12C (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R12C
        Insulin Pathway


    5 Kegg Pathways  (Kegg details for PPP1R12C):
        Vascular smooth muscle contraction
    Focal adhesion
    Regulation of actin cytoskeleton
    Oxytocin signaling pathway
    Proteoglycans in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP1R12C
    Interactions:

        Search GeneGlobe Interaction Network for PPP1R12C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1R12C (Q9BZL41, 2, 3 ENSP000002634334) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPRIPQ6WCQ12, 3, ENSP000003791564MINT-72806 I2D: score=3 STRING: ENSP00000379156
    IL16Q140053, ENSP000003029354I2D: score=3 STRING: ENSP00000302935
    CDC42BPAQ5VT253, ENSP000003557314I2D: score=1 STRING: ENSP00000355731
    MYL2P109163, ENSP000002288414I2D: score=1 STRING: ENSP00000228841
    PPP1CBP621403, ENSP000002961224I2D: score=1 STRING: ENSP00000296122
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R12C (PP12C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1R12C gene (2 alternative transcripts): 
    NM_001271618.1  NM_017607.3  

    Unigene Cluster for PPP1R12C:

    Protein phosphatase 1, regulatory subunit 12C
    Hs.631579  [show with all ESTs]
    Unigene Representative Sequence: AF211968
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263433(uc010yfs.2 uc002qix.3 uc002qiy.3) ENST00000591938
    ENST00000590268 ENST00000435544 ENST00000592993 ENST00000592754 ENST00000588277
    ENST00000586197 ENST00000586992 ENST00000376393
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPP1R12C (see all 32):
    hsa-miR-1224-3p hsa-miR-25 hsa-miR-218 hsa-miR-629* hsa-miR-92b hsa-miR-92a hsa-miR-32 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R12C 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat PPP1R12C

    Additional mRNA sequence: 

    AB209452.1 AF211968.1 AF312028.1 AK027086.1 AK129529.1 AK297187.1 AK297426.1 AL137618.1 
    BC008030.1 BC010628.1 

    9 DOTS entries:

    DT.216216  DT.91970981  DT.121500366  DT.91749482  DT.95236118  DT.91749478  DT.100652151  DT.99943722 
    DT.99969325 

    Selected AceView cDNA sequences (see all 217):

    BU173579 BQ897706 BE797207 T33476 H95951 AF312028 BE293582 CA391836 
    BU730941 BM908332 AI161177 CA390602 AI424915 AW338489 NM_017607 BU839107 
    AA577082 AI869477 AA595097 BU845056 BC008030 BM699425 AA724315 BQ957270 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12C (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -     -     -     -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:  -                                             
    SP2:  -                                             
    SP3:  -                                             
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for PPP1R12C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R12C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAATAGGG
    PPP1R12C Expression
    About this image


    PPP1R12C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PPP1R12C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R12C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631579

    UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4
    Tissue specificity: Ubiquitously expressed. Highly expressed in heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R12C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R12C gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r12c1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 83.78(n)1
    87.7(a)1
      7 (2.59 cM)5
    2328071  NM_029834.31  NP_084110.21 
     44815205 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R12C6
    protein phosphatase 1, regulatory subunit 12C
    52(a)
    1 ↔ 1
    GL343329.1(922431-968586)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167362 Xenopus laevis transcribed sequence with weak similarity more 74.74(n)    BJ029176.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp1r12c1 protein phosphatase 1, regulatory subunit 12C 55.88(n)
    53.42(a)
      570218  NM_001077579.1  NP_001071047.1 


    ENSEMBL Gene Tree for PPP1R12C (if available)
    TreeFam Gene Tree for PPP1R12C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R12C gene
    PPP1R13B2  PPP1R16B2  PPP1R12B2  PPP1R12A2  TP53BP22  PPP1R16A2  PPP1R13L2  
    14 SIMAP similar genes for PPP1R12C using alignment to 5 protein entries:     PP12C_HUMAN (see all proteins):
    NRARP    RAI14    ANKRD12    PPP1R12A    sm-M20    ASB7
    PPP1R27    ANKRD46    ANKRD54    FEM1B    ANKRD42    ANKRD6
    PPP1R12B    PSMD10

    Find genes that share paralogs with PPP1R12C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R12C (see all 831)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26036991,2
    C,H--55601792(-) CTTCTC/TTACTA 2 -- ds50018Minor allele frequency- T:0.00NA WA CSA 17
    rs104015581,2
    C,F,A,H--55602036(+) GTCTTG/ACCCGC 2 -- ds500115Minor allele frequency- A:0.46NS EA NA WA 964
    rs1453425161,2
    C--55602080(+) CCCCCA/GCCTGC 2 -- ds50010--------
    rs1911272501,2
    --55602091(+) GATCAC/TGCGGG 2 -- ds50010--------
    rs22590671,2
    C,F,A,H--55602115(+) CCTTCG/ACTCCC 2 -- ds500120Minor allele frequency- A:0.38NS EA NA WA 2342
    rs1823366261,2
    --55602177(+) CCCATC/TCCCCG 2 -- ds50010--------
    rs10438381,2
    C--55602310(-) GCACCA/CCAAAT 2 -- ut311Minor allele frequency- C:0.00NA 2
    rs2010236151,2
    --55602816(+) AAATAC/TGGGTG 2 -- ut310--------
    rs1485456971,2
    --55602891(+) TCCTTC/GAGGCG 4 L syn10--------
    rs1384374351,2
    C,F--55602903(+) TGGTTG/ATCAGC 4 /D syn11Minor allele frequency- A:0.00NA 4530

    HapMap Linkage Disequilibrium report for PPP1R12C (55602281 - 55628927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPP1R12C (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718949CNV Deletion23290073
    esv2718946CNV Deletion23290073
    esv2667609CNV Deletion23128226
    esv2718953CNV Deletion23290073
    esv1104675CNV Deletion17803354
    esv2718947CNV Deletion23290073
    esv2718948CNV Deletion23290073
    dgv581e201CNV Deletion23290073
    esv2676610CNV Deletion23128226
    esv2718872CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1R12C
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R12C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613245    OMIM disorders: --


    Find genes that share disorders with PPP1R12C           About GenesLikeMe


    Export disorders for PPP1R12C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R12C gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PPP1R12C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PubMed id 11399775)1, 2, 3 Tan I.... Leung T. (J. Biol. Chem. 2001)
    2. PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. (PubMed id 12923170)1, 2 Bannert N.... Kurth R. (J. Biol. Chem. 2003)
    3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    5. Chemical genetic screen for AMPKI+2 substrates uncovers a network of proteins involved in mitosis. (PubMed id 22137581)1 Banko M.R....Brunet A. (Mol. Cell 2011)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54776 HGNC: 14947 AceView: PPP1R12C Ensembl:ENSG00000125503 euGenes: HUgn54776
    ECgene: PPP1R12C Kegg: 54776 H-InvDB: PPP1R12C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R12C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R12C gene:
    Search GeneIP for patents involving PPP1R12C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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