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Aliases for PPP1R12C Gene

Aliases for PPP1R12C Gene

  • Protein Phosphatase 1 Regulatory Subunit 12C 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12C 2 3
  • Protein Phosphatase 1 Myosin-Binding Subunit Of 85 KDa 3 4
  • Protein Phosphatase 1 Myosin-Binding Subunit P85 3 4
  • Protein Phosphatase 1, Regulatory Subunit 12C 2 3
  • Leukocyte Receptor Cluster (LRC) Member 3 2 3
  • Myosin-Binding Subunit 85 2 3
  • LENG3 3 4
  • MBS85 3 4
  • Leukocyte Receptor Cluster (LRC) Encoded Novel Gene 3 3
  • P85 3
  • P84 3

External Ids for PPP1R12C Gene

Previous HGNC Symbols for PPP1R12C Gene

  • LENG3

Previous GeneCards Identifiers for PPP1R12C Gene

  • GC19M056464
  • GC19M056026
  • GC19M060278
  • GC19M060294
  • GC19M055602
  • GC19M051925

Summaries for PPP1R12C Gene

Entrez Gene Summary for PPP1R12C Gene

  • The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for PPP1R12C Gene

PPP1R12C (Protein Phosphatase 1 Regulatory Subunit 12C) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. An important paralog of this gene is PPP1R16A.

UniProtKB/Swiss-Prot for PPP1R12C Gene

  • Regulates myosin phosphatase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R12C Gene

Genomics for PPP1R12C Gene

Regulatory Elements for PPP1R12C Gene

Enhancers for PPP1R12C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R12C on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R12C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R12C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R12C Gene

55,090,913 bp from pter
55,117,600 bp from pter
26,688 bases
Minus strand

Genomic View for PPP1R12C Gene

Genes around PPP1R12C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R12C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R12C Gene

Proteins for PPP1R12C Gene

  • Protein details for PPP1R12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 12C
    Protein Accession:
    Secondary Accessions:
    • B4DME2
    • Q59FK8
    • Q6ZPD1
    • Q7L8F7
    • Q96HW1
    • Q9H5H5
    • Q9NT00

    Protein attributes for PPP1R12C Gene

    782 amino acids
    Molecular mass:
    84881 Da
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.
    • Sequence=AF211968; Type=Miscellaneous discrepancy; Note=Unspliced mRNA.; Evidence={ECO:0000305}; Sequence=BAB15651.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85179.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R12C Gene


neXtProt entry for PPP1R12C Gene

Proteomics data for PPP1R12C Gene at MOPED

Post-translational modifications for PPP1R12C Gene

  • Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R12C Gene

No data available for DME Specific Peptides for PPP1R12C Gene

Domains & Families for PPP1R12C Gene

Protein Domains for PPP1R12C Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 ANK repeats.
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with PPP1R12C: view

Function for PPP1R12C Gene

Molecular function for PPP1R12C Gene

UniProtKB/Swiss-Prot Function:
Regulates myosin phosphatase activity.

Gene Ontology (GO) - Molecular Function for PPP1R12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PPP1R12C: view
genes like me logo Genes that share phenotypes with PPP1R12C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R12C Gene

Localization for PPP1R12C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R12C Gene

Cytoplasm. Note=Along actomyosin filaments and stress fibers. {ECO:0000269 PubMed:11399775, ECO:0000269 PubMed:12923170}.

Subcellular locations from

Jensen Localization Image for PPP1R12C Gene COMPARTMENTS Subcellular localization image for PPP1R12C gene
Compartment Confidence
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PPP1R12C Gene

Pathways & Interactions for PPP1R12C Gene

genes like me logo Genes that share pathways with PPP1R12C: view

SIGNOR curated interactions for PPP1R12C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R12C Gene


Drugs & Compounds for PPP1R12C Gene

No Compound Related Data Available

Transcripts for PPP1R12C Gene

Unigene Clusters for PPP1R12C Gene

Protein phosphatase 1, regulatory subunit 12C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP3: - - - -
SP7: -
SP11: - - - - - - - - -

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -

Relevant External Links for PPP1R12C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R12C Gene

mRNA expression in normal human tissues for PPP1R12C Gene

Protein differential expression in normal tissues from HIPED for PPP1R12C Gene

This gene is overexpressed in Gallbladder (10.2) and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R12C Gene

SOURCE GeneReport for Unigene cluster for PPP1R12C Gene Hs.631579

mRNA Expression by UniProt/SwissProt for PPP1R12C Gene

Tissue specificity: Ubiquitously expressed. Highly expressed in heart.
genes like me logo Genes that share expression patterns with PPP1R12C: view

Protein tissue co-expression partners for PPP1R12C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP1R12C Gene

Orthologs for PPP1R12C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R12C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R12C 35
  • 86.82 (n)
  • 91.15 (a)
PPP1R12C 36
  • 83 (a)
(Canis familiaris)
Mammalia PPP1R12C 35
  • 85.79 (n)
  • 90.03 (a)
PPP1R12C 36
  • 87 (a)
(Mus musculus)
Mammalia Ppp1r12c 35
  • 83.78 (n)
  • 87.7 (a)
Ppp1r12c 16
Ppp1r12c 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Ppp1r12c 35
  • 83.09 (n)
  • 87.82 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R12C 36
  • 70 (a)
(Pan troglodytes)
Mammalia PPP1R12C 36
  • 99 (a)
(Anolis carolinensis)
Reptilia PPP1R12C 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r12c 35
  • 55.95 (n)
  • 59.03 (a)
Str.15086 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16736 35
(Danio rerio)
Actinopterygii ppp1r12c 35
  • 55.88 (n)
  • 53.42 (a)
ppp1r12c 36
  • 47 (a)
Species with no ortholog for PPP1R12C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R12C Gene

Gene Tree for PPP1R12C (if available)
Gene Tree for PPP1R12C (if available)

Paralogs for PPP1R12C Gene

Paralogs for PPP1R12C Gene

genes like me logo Genes that share paralogs with PPP1R12C: view

Variants for PPP1R12C Gene

Sequence variations from dbSNP and Humsavar for PPP1R12C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35849605 - 55,095,576(+) AAAGC(A/G)CCTGG nc-transcript-variant, reference, missense
rs7259847 -- 55,110,324(+) GGTGC(A/G)GTGGG intron-variant
rs7259963 -- 55,103,392(+) GGAAC(A/G)GACTG intron-variant
rs12981401 -- 55,093,539(+) agccc(C/T)tcctc intron-variant
rs12981737 -- 55,115,264(+) CAGGA(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R12C Gene

Variant ID Type Subtype PubMed ID
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv912446 CNV Loss 21882294
dgv1131e1 CNV Complex 17122850
esv34356 CNV Gain 17911159
nsv817874 CNV Loss 17921354
dgv4015n71 CNV Loss 21882294
nsv912451 CNV Loss 21882294
nsv512597 CNV Loss 21212237
esv2718946 CNV Deletion 23290073
esv27516 CNV Loss 19812545
esv2718947 CNV Deletion 23290073
esv2676610 CNV Deletion 23128226
esv2718948 CNV Deletion 23290073
esv1366716 CNV Deletion 17803354
esv2718949 CNV Deletion 23290073
dgv581e201 CNV Deletion 23290073
nsv138336 CNV Loss 16902084
esv2718953 CNV Deletion 23290073
esv1010486 CNV Deletion 20482838
esv1104675 CNV Deletion 17803354

Variation tolerance for PPP1R12C Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R12C Gene

Disorders for PPP1R12C Gene

Relevant External Links for PPP1R12C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R12C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R12C Gene

Publications for PPP1R12C Gene

  1. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I. … Leung T. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1I^MYPT1 phosphatase complex and the SCFI^TrCP E3 ubiquitin ligase. (PMID: 24785407) Banerjee S. … Alessi D.R. (Biochem. J. 2014) 3
  5. Adeno-associated virus Rep represses the human integration site promoter by two pathways that are similar to those required for the regulation of the viral p5 promoter. (PMID: 24829354) Dutheil N. … Henckaerts E. (J. Virol. 2014) 3

Products for PPP1R12C Gene

Sources for PPP1R12C Gene