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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R12C Gene

protein-coding   GIFtS: 53
GCID: GC19M055602

Protein Phosphatase 1, Regulatory Subunit 12C

(Previous names: leukocyte receptor cluster (LRC) member 3, protein phosphatase...)
(Previous symbol: LENG3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory Subunit 12C1 2     Protein Phosphatase 1 Myosin-Binding Subunit Of 85 KDa2 3
LENG31 2 3     Protein Phosphatase 1 Myosin-Binding Subunit P852 3
MBS852 3 5     Leukocyte Receptor Cluster (LRC) Encoded Novel Gene 32
Leukocyte Receptor Cluster (LRC) Member 31 2     p842
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12C1 2     p852
Myosin-Binding Subunit 851 2     Protein Phosphatase 1 Regulatory Subunit 12C2

External Ids:    HGNC: 149471   Entrez Gene: 547762   Ensembl: ENSG000001255037   OMIM: 6132455   UniProtKB: Q9BZL43   

Export aliases for PPP1R12C gene to outside databases

Previous GC identifers: GC19M056464 GC19M056026 GC19M060278 GC19M060294 GC19M051925


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R12C Gene:
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein
phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Oct 2012)

GeneCards Summary for PPP1R12C Gene: 
PPP1R12C (protein phosphatase 1, regulatory subunit 12C) is a protein-coding gene. Diseases associated with PPP1R12C include macular degeneration, and ataxia, and among its related super-pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include protein binding. An important paralog of this gene is PPP1R13B.

UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4
Function: Regulates myosin phosphatase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R12C gene promoter:
         p53   Tal-1   AML1a   STAT5A   RelA   NF-kappaB   E47   NF-kappaB1   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R12C promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R12C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R12C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

PPP1R12C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R12C gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055602:  view genomic region     (about GC identifiers)

Start:
55,602,281 bp from pter      End:
55,628,927 bp from pter
Size:
26,647 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 12C  
Size: 782 amino acids; 84881 Da
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory
subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16.
Interacts with the coiled-coil domain of MPRIP
Subcellular location: Cytoplasm. Note=Along actomyosin filaments and stress fibers
Caution: Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by
itself and is a part of the PPP1R12C gene
Sequence caution: Sequence=AF211968; Type=Miscellaneous discrepancy; Note=Unspliced mRNA; Sequence=BAB15651.1;
Type=Erroneous initiation; Sequence=BAC85179.1; Type=Erroneous initiation;
Secondary accessions: Q59FK8 Q6ZPD1 Q7L8F7 Q96HW1 Q9H5H5 Q9NT00
Alternative splicing: 4 isoforms:  Q9BZL4-1   Q9BZL4-2   Q9BZL4-3   Q9BZL4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP1R12C: NX_Q9BZL4

Explore proteomics data for PPP1R12C at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Thr-560 is essential for its interaction with PPP1CB
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZL4

  • PPP1R12C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP1R12C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258547.1  NP_060077.1  

    ENSEMBL proteins: 
     ENSP00000263433   ENSP00000468148   ENSP00000387833   ENSP00000465957   ENSP00000365573  

    Human Recombinant Protein Products for PPP1R12C: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PPP1R12C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR017401 Pase-1_reg_su_12A/B/C_euk
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BZL4

    ProtoNet protein and cluster: Q9BZL4

    UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4
    Similarity: Contains 4 ANK repeats


    PPP1R12C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP12C_HUMAN, Q9BZL4
    Function: Regulates myosin phosphatase activity

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    PPP1R12C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP1R12C:
     Decreased viability 

    Animal Models:
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    hsa-miR-1224-3p hsa-miR-25 hsa-miR-218 hsa-miR-629* hsa-miR-92b hsa-miR-92a hsa-miR-32 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R12C 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP1R12C About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3Focal Adhesion
    Focal adhesion0.64
    4PEDF Induced Signaling
    IL-6 Pathway0.61
    5Rho Family GTPases
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R12C (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R12C
        Insulin Pathway


    4         Kegg Pathways  (Kegg details for PPP1R12C):
        Vascular smooth muscle contraction
    Focal adhesion
    Regulation of actin cytoskeleton
    Proteoglycans in cancer


    PPP1R12C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP1R12C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/21 Interacting proteins for PPP1R12C (Q9BZL41, 2, 3 ENSP000002634334) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPRIPQ6WCQ12, 3, ENSP000003791564MINT-72806 I2D: score=3 STRING: ENSP00000379156
    IL16Q140053, ENSP000003029354I2D: score=3 STRING: ENSP00000302935
    CDC42BPAQ5VT253, ENSP000003557314I2D: score=1 STRING: ENSP00000355731
    MYL2P109163, ENSP000002288414I2D: score=1 STRING: ENSP00000228841
    PPP1CBP621403, ENSP000002961224I2D: score=1 STRING: ENSP00000296122
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R12C (PP12C)

    Search CenterWatch for drugs/clinical trials and news about PPP1R12C / PP12C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP1R12C gene (2 alternative transcripts): 
    NM_001271618.1  NM_017607.3  

    Unigene Cluster for PPP1R12C:

    Protein phosphatase 1, regulatory subunit 12C
    Hs.631579  [show with all ESTs]
    Unigene Representative Sequence: AF211968
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263433(uc010yfs.2 uc002qix.3 uc002qiy.3) ENST00000591938
    ENST00000590268 ENST00000435544 ENST00000592993 ENST00000592754 ENST00000588277
    ENST00000586197 ENST00000586992 ENST00000376393
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    hsa-miR-1224-3p hsa-miR-25 hsa-miR-218 hsa-miR-629* hsa-miR-92b hsa-miR-92a hsa-miR-32 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R12C 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209452.1 AF211968.1 AF312028.1 AK027086.1 AK129529.1 AK297187.1 AK297426.1 AL137618.1 
    BC008030.1 BC010628.1 

    9 DOTS entries:

    DT.216216  DT.91970981  DT.121500366  DT.91749482  DT.95236118  DT.91749478  DT.100652151  DT.99943722 
    DT.99969325 

    24/217 AceView cDNA sequences (see all 217):

    BQ897706 T33476 AF312028 AF211968 BE293582 BQ005821 CD244239 CA391836 
    BQ957270 H95951 BU173579 BE305140 AA595097 AW675175 C01728 BC008030 
    BE797207 CR622216 AA724315 BM699425 AI161177 BG912328 AL137618 BQ894778 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12C (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -     -     -     -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:  -                                             
    SP2:  -                                             
    SP3:  -                                             
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for PPP1R12C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R12C expression in normal human tissues (normalized intensities)      PPP1R12C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAATAGGG
    PPP1R12C Expression
    About this image


    PPP1R12C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See PPP1R12C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R12C

    SOURCE GeneReport for Unigene cluster: Hs.631579

    UniProtKB/Swiss-Prot: PP12C_HUMAN, Q9BZL4
    Tissue specificity: Ubiquitously expressed. Highly expressed in heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R12C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R12C gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r12c1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 83.87(n)1
    87.77(a)1
      7 (2.59 cM)5
    2328071  NM_029834.31  NP_084110.21 
     44815205 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    49(a)
    possible ortholog
    GL343329.1(922431-968586)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167362 Xenopus laevis transcribed sequence with weak similarity more 74.74(n)    BJ029176.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp1r12c1 protein phosphatase 1, regulatory subunit 12C 53.77(n)
    51.01(a)
      570218  NM_001077579.1  NP_001071047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mbs6
    Myosin binding subunit
    18(a)
    1 → many
    3L(16045059-16075126)
    worm
    (Caenorhabditis elegans)
    Secernentea mel-116
    Protein MEL-11, isoform b
    19(a)
    1 → many
    II(9358531-9369087)


    ENSEMBL Gene Tree for PPP1R12C (if available)
    TreeFam Gene Tree for PPP1R12C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R12C gene
    PPP1R13B2  PPP1R16B2  PPP1R12B2  PPP1R12A2  TP53BP22  PPP1R16A2  PPP1R13L2  
    14 SIMAP similar genes for PPP1R12C using alignment to 5 protein entries:     PP12C_HUMAN (see all proteins):
    NRARP    RAI14    ANKRD12    PPP1R12A    sm-M20    ASB7
    PPP1R27    ANKRD46    ANKRD54    FEM1B    ANKRD42    ANKRD6
    PPP1R12B    PSMD10

    PPP1R12C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/831 SNPs in PPP1R12C are shown (see all 831)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26036991,2
    C,H--55601792(-) CTTCTC/TTACTA 2 -- ds50018Minor allele frequency- T:0.00NA WA CSA 17
    rs104015581,2
    C,F,A,H--55602036(+) GTCTTG/ACCCGC 2 -- ds500115Minor allele frequency- A:0.46NS EA NA WA 964
    rs1453425161,2
    C--55602080(+) CCCCCA/GCCTGC 2 -- ds50010--------
    rs1911272501,2
    --55602091(+) GATCAC/TGCGGG 2 -- ds50010--------
    rs22590671,2
    C,F,A,H--55602115(+) CCTTCG/ACTCCC 2 -- ds500120Minor allele frequency- A:0.38NS EA NA WA 2342
    rs1823366261,2
    --55602177(+) CCCATC/TCCCCG 2 -- ds50010--------
    rs10438381,2
    C--55602310(-) GCACCA/CCAAAT 2 -- ut311Minor allele frequency- C:0.00NA 2
    rs2010236151,2
    --55602816(+) AAATAC/TGGGTG 2 -- ut310--------
    rs1485456971,2
    --55602891(+) TCCTTC/GAGGCG 4 L syn10--------
    rs1384374351,2
    C,F--55602903(+) TGGTTG/ATCAGC 4 /D syn11Minor allele frequency- A:0.00NA 4530

    HapMap Linkage Disequilibrium report for PPP1R12C (55602281 - 55628927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for PPP1R12C (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718949CNV Deletion23290073
    esv2718946CNV Deletion23290073
    esv2667609CNV Deletion23128226
    esv2718953CNV Deletion23290073
    esv1104675CNV Deletion17803354
    esv2718947CNV Deletion23290073
    esv2718948CNV Deletion23290073
    dgv581e201CNV Deletion23290073
    esv2676610CNV Deletion23128226
    esv2718872CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613245    OMIM disorders: --

    3 diseases for PPP1R12C:    About MalaCards
    macular degeneration    ataxia    breast cancer


    PPP1R12C for disorders           About GeneDecksing


    Export disorders for PPP1R12C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R12C gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with PPP1R12C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PubMed id 11399775)1, 2, 3 Tan I.... Leung T. (2001)
    2. PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. (PubMed id 12923170)1, 2 Bannert N.... Kurth R. (2003)
    3. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    4. Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. (PubMed id 22137581)1 Banko M.R....Brunet A. (2011)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54776 HGNC: 14947 AceView: PPP1R12C Ensembl:ENSG00000125503 euGenes: HUgn54776
    ECgene: PPP1R12C Kegg: 54776 H-InvDB: PPP1R12C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R12C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1R12C gene:
    Search GeneIP for patents involving PPP1R12C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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