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Aliases for PPP1R12C Gene

Aliases for PPP1R12C Gene

  • Protein Phosphatase 1 Regulatory Subunit 12C 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12C 2 3
  • Protein Phosphatase 1 Myosin-Binding Subunit Of 85 KDa 3 4
  • Protein Phosphatase 1 Myosin-Binding Subunit P85 3 4
  • Leukocyte Receptor Cluster (LRC) Member 3 2 3
  • Myosin-Binding Subunit 85 2 3
  • LENG3 3 4
  • MBS85 3 4
  • Leukocyte Receptor Cluster (LRC) Encoded Novel Gene 3 3
  • Protein Phosphatase 1, Regulatory Subunit 12C 2
  • P85 3
  • P84 3

External Ids for PPP1R12C Gene

Previous HGNC Symbols for PPP1R12C Gene

  • LENG3

Previous GeneCards Identifiers for PPP1R12C Gene

  • GC19M056464
  • GC19M056026
  • GC19M060278
  • GC19M060294
  • GC19M055602
  • GC19M051925

Summaries for PPP1R12C Gene

Entrez Gene Summary for PPP1R12C Gene

  • The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for PPP1R12C Gene

PPP1R12C (Protein Phosphatase 1 Regulatory Subunit 12C) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is PPP1R12A.

UniProtKB/Swiss-Prot for PPP1R12C Gene

  • Regulates myosin phosphatase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R12C Gene

Genomics for PPP1R12C Gene

Regulatory Elements for PPP1R12C Gene

Enhancers for PPP1R12C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055095 1 Ensembl ENCODE 19 +20.3 20330 4.4 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ETS1 GLIS2 ZNF207 ZNF143 RDH13 EPS8L1 PPP1R12C CDC42EP5 GP6 TNNI3 DNAAF3 ENSG00000239137 GC19M055111
GH19F055091 0.5 Ensembl ENCODE 18.9 +24.4 24360 3.3 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 EPS8L1 PPP1R12C PRPF31 U2AF2 ZNF580 RDH13 GP6 TNNI3 DNAAF3 ENSG00000239137
GH19F055086 0.9 FANTOM5 ENCODE 12.1 +29.8 29782 2.5 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CDC42EP5 EPS8L1 PPP1R12C GP6 U2AF2 BRSK1 GC19M055111
GH19F055087 0.5 ENCODE 12.1 +31.3 31323 0.2 POLR2A ZNF600 PPP1R12C GP6 BRSK1 EPS8L1 GC19M055111
GH19F055111 1.2 FANTOM5 ENCODE 9.4 +2.2 2218 8.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 EPS8L1 RDH13 U2AF2 LENG8-AS1 CDC42EP5 ENSG00000235681 ENSG00000267523 ZNF580 KMT5C TNNT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPP1R12C on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R12C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PPP1R12C Gene

55,090,913 bp from pter
55,117,600 bp from pter
26,688 bases
Minus strand

Genomic View for PPP1R12C Gene

Genes around PPP1R12C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R12C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R12C Gene

Proteins for PPP1R12C Gene

  • Protein details for PPP1R12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 12C
    Protein Accession:
    Secondary Accessions:
    • B4DME2
    • Q59FK8
    • Q6ZPD1
    • Q7L8F7
    • Q96HW1
    • Q9H5H5
    • Q9NT00

    Protein attributes for PPP1R12C Gene

    782 amino acids
    Molecular mass:
    84881 Da
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.
    • Sequence=AF211968; Type=Miscellaneous discrepancy; Note=Unspliced mRNA.; Evidence={ECO:0000305}; Sequence=BAB15651.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85179.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R12C Gene


neXtProt entry for PPP1R12C Gene

Post-translational modifications for PPP1R12C Gene

  • Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R12C Gene

No data available for DME Specific Peptides for PPP1R12C Gene

Domains & Families for PPP1R12C Gene

Protein Domains for PPP1R12C Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 ANK repeats.
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with PPP1R12C: view

Function for PPP1R12C Gene

Molecular function for PPP1R12C Gene

UniProtKB/Swiss-Prot Function:
Regulates myosin phosphatase activity.

Gene Ontology (GO) - Molecular Function for PPP1R12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PPP1R12C: view
genes like me logo Genes that share phenotypes with PPP1R12C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R12C Gene

Localization for PPP1R12C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R12C Gene

Cytoplasm. Note=Along actomyosin filaments and stress fibers. {ECO:0000269 PubMed:11399775, ECO:0000269 PubMed:12923170}.

Subcellular locations from

Jensen Localization Image for PPP1R12C Gene COMPARTMENTS Subcellular localization image for PPP1R12C gene
Compartment Confidence
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPP1R12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R12C: view

Pathways & Interactions for PPP1R12C Gene

genes like me logo Genes that share pathways with PPP1R12C: view

SIGNOR curated interactions for PPP1R12C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R12C Gene


Transcripts for PPP1R12C Gene

Unigene Clusters for PPP1R12C Gene

Protein phosphatase 1, regulatory subunit 12C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP3: - - - -
SP7: -
SP11: - - - - - - - - -

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -

Relevant External Links for PPP1R12C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R12C Gene

mRNA expression in normal human tissues for PPP1R12C Gene

Protein differential expression in normal tissues from HIPED for PPP1R12C Gene

This gene is overexpressed in Gallbladder (10.2) and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R12C Gene

Protein tissue co-expression partners for PPP1R12C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R12C Gene:


SOURCE GeneReport for Unigene cluster for PPP1R12C Gene:


mRNA Expression by UniProt/SwissProt for PPP1R12C Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in heart.
genes like me logo Genes that share expression patterns with PPP1R12C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP1R12C Gene

Orthologs for PPP1R12C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R12C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R12C 35
  • 99 (a)
(Bos Taurus)
Mammalia PPP1R12C 34 35
  • 86.82 (n)
(Canis familiaris)
Mammalia PPP1R12C 34 35
  • 85.79 (n)
(Mus musculus)
Mammalia Ppp1r12c 34 16 35
  • 83.78 (n)
(Rattus norvegicus)
Mammalia Ppp1r12c 34
  • 83.09 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R12C 35
  • 70 (a)
(Anolis carolinensis)
Reptilia PPP1R12C 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r12c 34
  • 55.95 (n)
Str.15086 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16736 34
(Danio rerio)
Actinopterygii ppp1r12c 34 35
  • 55.88 (n)
Species where no ortholog for PPP1R12C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R12C Gene

Gene Tree for PPP1R12C (if available)
Gene Tree for PPP1R12C (if available)

Paralogs for PPP1R12C Gene

Paralogs for PPP1R12C Gene

genes like me logo Genes that share paralogs with PPP1R12C: view

Variants for PPP1R12C Gene

Sequence variations from dbSNP and Humsavar for PPP1R12C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401227 -- 55,103,206(+) ATAAA(C/T)AATAA intron-variant
rs10401558 -- 55,090,668(+) GTCTT(A/G)CCCGC downstream-variant-500B
rs10407760 -- 55,119,518(+) CCTCC(C/T)GAGTA upstream-variant-2KB
rs10409378 -- 55,092,033(+) CGGGC(C/G)AGGCC intron-variant
rs10410929 -- 55,092,020(+) AGCCC(C/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R12C Gene

Variant ID Type Subtype PubMed ID
dgv1819n106 OTHER inversion 24896259
dgv540e201 CNV deletion 23290073
esv1010486 CNV deletion 20482838
esv1104675 CNV deletion 17803354
esv1366716 CNV deletion 17803354
esv2667609 CNV deletion 23128226
esv2676610 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2718946 CNV deletion 23290073
esv2718947 CNV deletion 23290073
esv2718948 CNV deletion 23290073
esv2718949 CNV deletion 23290073
esv2718953 CNV deletion 23290073
esv27516 CNV loss 19812545
esv2758772 CNV gain 17122850
esv3083790 CNV deletion 24192839
esv34356 CNV gain 17911159
esv3644829 CNV gain 21293372
esv3644836 CNV gain 21293372
esv3893251 CNV loss 25118596
nsv1055961 CNV gain+loss 25217958
nsv1060034 CNV gain 25217958
nsv1072366 CNV deletion 25765185
nsv1079034 OTHER inversion 25765185
nsv1143924 CNV deletion 24896259
nsv1150276 OTHER inversion 26484159
nsv138336 CNV deletion 16902084
nsv512597 CNV loss 21212237
nsv817874 CNV loss 17921354

Variation tolerance for PPP1R12C Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R12C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R12C Gene

Disorders for PPP1R12C Gene

Relevant External Links for PPP1R12C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R12C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R12C Gene

Publications for PPP1R12C Gene

  1. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I. … Leung T. (J. Biol. Chem. 2001) 2 3 4 64
  2. PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. (PMID: 12923170) Bannert N. … Kurth R. (J. Biol. Chem. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1I^MYPT1 phosphatase complex and the SCFI^TrCP E3 ubiquitin ligase. (PMID: 24785407) Banerjee S. … Alessi D.R. (Biochem. J. 2014) 3 64

Products for PPP1R12C Gene

Sources for PPP1R12C Gene

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