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Aliases for PPP1R12B Gene

Aliases for PPP1R12B Gene

  • Protein Phosphatase 1 Regulatory Subunit 12B 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12B 2 3
  • Myosin Phosphatase-Targeting Subunit 2 3 4
  • Myosin Phosphatase Target Subunit 2 3 4
  • MYPT2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 12B 2
  • Myosin Phosphatase Regulatory Subunit 2
  • Myosin Phosphatase, Target Subunit 2 2
  • PP1bp55 3

External Ids for PPP1R12B Gene

Previous HGNC Symbols for PPP1R12B Gene

  • MYPT2

Previous GeneCards Identifiers for PPP1R12B Gene

  • GC01P200001
  • GC01P197751
  • GC01P198784
  • GC01P199606
  • GC01P199049
  • GC01P200584
  • GC01P202317
  • GC01P173483

Summaries for PPP1R12B Gene

Entrez Gene Summary for PPP1R12B Gene

  • Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R12B Gene

PPP1R12B (Protein Phosphatase 1 Regulatory Subunit 12B) is a Protein Coding gene. Among its related pathways are mTOR Pathway and Vascular smooth muscle contraction. GO annotations related to this gene include enzyme activator activity and phosphatase regulator activity. An important paralog of this gene is PPP1R12A.

UniProtKB/Swiss-Prot for PPP1R12B Gene

  • Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Gene Wiki entry for PPP1R12B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R12B Gene

Genomics for PPP1R12B Gene

Regulatory Elements for PPP1R12B Gene

Enhancers for PPP1R12B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G202103 2 FANTOM5 Ensembl ENCODE dbSUPER 2.7 -241.8 -241752 6.6 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZBTB7B YY1 ZNF766 FOS KLF13 ELF3 ELF3-AS1 ENSG00000249007 TIMM17A GPR37L1 PTPRVP LGR6 PPP1R12B CRIP1P3
GH01G202074 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2 -272.0 -271998 3.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A ZBTB7B ZNF766 FOS IPO9-AS1 IPO9 TIMM17A PPP1R12B ELF3 ENSG00000212512 CRIP1P3
GH01G202042 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -302.9 -302867 7.5 HDGF PKNOX1 FOXA2 ARNT MLX CREB3L1 ARID4B SIN3A ZBTB7B YY1 ELF3 ENSG00000249007 ELF3-AS1 LMOD1 LGR6 PPP1R12B ENSG00000235811 ENSG00000212512
GH01G202343 1.1 Ensembl ENCODE 0.7 -4.9 -4888 0.4 HDGF ARNT YBX1 ZBTB40 RAD21 RFX5 ZNF366 ZNF143 RELB SMARCA5 UBE2T PPP1R12B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R12B on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R12B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PPP1R12B Gene

202,348,699 bp from pter
202,592,706 bp from pter
244,008 bases
Plus strand

Genomic View for PPP1R12B Gene

Genes around PPP1R12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R12B Gene

Proteins for PPP1R12B Gene

  • Protein details for PPP1R12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 12B
    Protein Accession:
    Secondary Accessions:
    • A8MYF5
    • B7ZMN6
    • Q2TAI8
    • Q5T506
    • Q5VUK2
    • Q8N179
    • Q9HCB7
    • Q9HCB8

    Protein attributes for PPP1R12B Gene

    982 amino acids
    Molecular mass:
    110404 Da
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.

    Alternative splice isoforms for PPP1R12B Gene


neXtProt entry for PPP1R12B Gene

Post-translational modifications for PPP1R12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R12B Gene

Domains & Families for PPP1R12B Gene

Protein Domains for PPP1R12B Gene

Suggested Antigen Peptide Sequences for PPP1R12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R12B: view

No data available for UniProtKB/Swiss-Prot for PPP1R12B Gene

Function for PPP1R12B Gene

Molecular function for PPP1R12B Gene

UniProtKB/Swiss-Prot Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Gene Ontology (GO) - Molecular Function for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11067852
GO:0008047 enzyme activator activity TAS 9570949
GO:0019208 phosphatase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PPP1R12B: view
genes like me logo Genes that share phenotypes with PPP1R12B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R12B Gene

Localization for PPP1R12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R12B Gene

Cytoplasm. Note=Along actomyosin filaments and stress fibers.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R12B gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030018 Z disc ISS --
GO:0031672 A band ISS --
genes like me logo Genes that share ontologies with PPP1R12B: view

Pathways & Interactions for PPP1R12B Gene

genes like me logo Genes that share pathways with PPP1R12B: view

Interacting Proteins for PPP1R12B Gene

SIGNOR curated interactions for PPP1R12B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006937 regulation of muscle contraction TAS 9570949
GO:0007165 signal transduction TAS 9570949
GO:0043085 positive regulation of catalytic activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R12B: view

Drugs & Compounds for PPP1R12B Gene

No Compound Related Data Available

Transcripts for PPP1R12B Gene

Unigene Clusters for PPP1R12B Gene

Protein phosphatase 1, regulatory subunit 12B:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^
SP1: - -
SP2: - -
SP3: - -
SP5: - -
SP6: -

ExUns: 22 ^ 23 ^ 24

Relevant External Links for PPP1R12B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R12B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R12B Gene

This gene is overexpressed in Artery - Tibial (x4.2), Heart - Left Ventricle (x4.1), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for PPP1R12B Gene

This gene is overexpressed in Seminal vesicle (10.8), Uterus (8.0), Colon (7.4), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R12B Gene

Protein tissue co-expression partners for PPP1R12B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R12B Gene:


SOURCE GeneReport for Unigene cluster for PPP1R12B Gene:


mRNA Expression by UniProt/SwissProt for PPP1R12B Gene:

Tissue specificity: Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific.

Evidence on tissue expression from TISSUES for PPP1R12B Gene

  • Nervous system(4.8)
  • Heart(4.5)
  • Muscle(3.1)
genes like me logo Genes that share expression patterns with PPP1R12B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R12B Gene

Orthologs for PPP1R12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R12B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R12B 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia PPP1R12B 34 35
  • 87.36 (n)
(Mus musculus)
Mammalia Ppp1r12b 35
  • 87 (a)
(Monodelphis domestica)
Mammalia PPP1R12B 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R12B 35
  • 74 (a)
(Bos Taurus)
Mammalia PPP1R12B 35
  • 58 (a)
(Gallus gallus)
Aves LOC101749340 34
  • 70.53 (n)
PPP1R12B 35
  • 69 (a)
(Anolis carolinensis)
Reptilia PPP1R12B 35
  • 66 (a)
(Danio rerio)
Actinopterygii PPP1R12B 35
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mbs 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for PPP1R12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R12B Gene

Gene Tree for PPP1R12B (if available)
Gene Tree for PPP1R12B (if available)

Paralogs for PPP1R12B Gene

Paralogs for PPP1R12B Gene Pseudogenes for PPP1R12B Gene

genes like me logo Genes that share paralogs with PPP1R12B: view

Variants for PPP1R12B Gene

Sequence variations from dbSNP and Humsavar for PPP1R12B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000032005 -- 202,380,848(+) TCTCA(A/G)GTATC intron-variant
rs1000076988 -- 202,524,784(+) CATTT(C/G)GGCTG intron-variant
rs1000112881 -- 202,504,733(+) TTAAG(A/G)GGACA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000133777 -- 202,396,623(+) CTTTT(A/T)TGAGA intron-variant
rs1000139814 -- 202,435,323(+) AGATA(G/T)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R12B Gene

Variant ID Type Subtype PubMed ID
dgv96n67 CNV loss 20364138
dgv97n67 CNV loss 20364138
esv1006468 CNV deletion 20482838
esv1009152 CNV gain 20482838
esv2027802 CNV deletion 18987734
esv2379385 CNV deletion 18987734
esv24486 CNV loss 19812545
esv2673485 CNV deletion 23128226
esv2721584 CNV deletion 23290073
esv2721595 CNV deletion 23290073
esv2721606 CNV deletion 23290073
esv29503 CNV loss 19812545
esv3588582 CNV gain 21293372
esv3588583 CNV loss 21293372
esv3891070 CNV loss 25118596
esv8498 CNV loss 19470904
nsv1068420 CNV deletion 25765185
nsv159751 CNV deletion 16902084
nsv433192 CNV loss 18776910
nsv471538 CNV gain 19718026
nsv473451 CNV novel sequence insertion 20440878
nsv514037 CNV gain 21397061
nsv514038 CNV gain 21397061
nsv516501 CNV gain 19592680
nsv832337 CNV loss 17160897
nsv946578 CNV duplication 23825009
nsv946579 CNV duplication 23825009
nsv946581 CNV duplication 23825009
nsv946582 CNV duplication 23825009
nsv946583 CNV duplication 23825009
nsv946584 CNV duplication 23825009
nsv958065 CNV deletion 24416366

Variation tolerance for PPP1R12B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R12B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R12B Gene

Disorders for PPP1R12B Gene

Relevant External Links for PPP1R12B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R12B Gene

Publications for PPP1R12B Gene

  1. A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. (PMID: 9570949) Fujioka M. … Ito M. (Genomics 1998) 2 3 4 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for PPP1R12B Gene

Sources for PPP1R12B Gene

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