Aliases for PPP1R12B Gene
External Ids for PPP1R12B Gene
Previous HGNC Symbols for PPP1R12B Gene
Previous GeneCards Identifiers for PPP1R12B Gene
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]
GeneCards Summary for PPP1R12B Gene
PPP1R12B (Protein Phosphatase 1 Regulatory Subunit 12B) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by Rho GTPases. GO annotations related to this gene include enzyme activator activity and phosphatase regulator activity. An important paralog of this gene is PPP1R12C.
UniProtKB/Swiss-Prot for PPP1R12B Gene
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.