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Aliases for PPP1R12B Gene

Aliases for PPP1R12B Gene

  • Protein Phosphatase 1 Regulatory Subunit 12B 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12B 2 3
  • Protein Phosphatase 1, Regulatory Subunit 12B 2 3
  • Myosin Phosphatase-Targeting Subunit 2 3 4
  • Myosin Phosphatase Target Subunit 2 3 4
  • MYPT2 3 4
  • Myosin Phosphatase Regulatory Subunit 2
  • Myosin Phosphatase, Target Subunit 2 3
  • Myosin Phosphatase 2
  • Target Subunit 2 2
  • PP1bp55 3

External Ids for PPP1R12B Gene

Previous HGNC Symbols for PPP1R12B Gene

  • MYPT2

Previous GeneCards Identifiers for PPP1R12B Gene

  • GC01P200001
  • GC01P197751
  • GC01P198784
  • GC01P199606
  • GC01P199049
  • GC01P200584
  • GC01P202317
  • GC01P173483

Summaries for PPP1R12B Gene

Entrez Gene Summary for PPP1R12B Gene

  • Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R12B Gene

PPP1R12B (Protein Phosphatase 1 Regulatory Subunit 12B) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by Rho GTPases. GO annotations related to this gene include enzyme activator activity and phosphatase regulator activity. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R12B Gene

  • Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Gene Wiki entry for PPP1R12B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R12B Gene

Genomics for PPP1R12B Gene

Regulatory Elements for PPP1R12B Gene

Enhancers for PPP1R12B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R12B on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R12B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R12B on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R12B Gene

Chromosome:
1
Start:
202,348,699 bp from pter
End:
202,592,706 bp from pter
Size:
244,008 bases
Orientation:
Plus strand

Genomic View for PPP1R12B Gene

Genes around PPP1R12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R12B Gene

Proteins for PPP1R12B Gene

  • Protein details for PPP1R12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60237-MYPT2_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 12B
    Protein Accession:
    O60237
    Secondary Accessions:
    • A8MYF5
    • B7ZMN6
    • Q2TAI8
    • Q5T506
    • Q5VUK2
    • Q8N179
    • Q9HCB7
    • Q9HCB8

    Protein attributes for PPP1R12B Gene

    Size:
    982 amino acids
    Molecular mass:
    110404 Da
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.

    Alternative splice isoforms for PPP1R12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R12B Gene

Proteomics data for PPP1R12B Gene at MOPED

Post-translational modifications for PPP1R12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R12B Gene

Domains & Families for PPP1R12B Gene

Protein Domains for PPP1R12B Gene

Suggested Antigen Peptide Sequences for PPP1R12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60237

UniProtKB/Swiss-Prot:

MYPT2_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with PPP1R12B: view

Function for PPP1R12B Gene

Molecular function for PPP1R12B Gene

UniProtKB/Swiss-Prot Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Gene Ontology (GO) - Molecular Function for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11067852
genes like me logo Genes that share ontologies with PPP1R12B: view
genes like me logo Genes that share phenotypes with PPP1R12B: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R12B Gene

Localization for PPP1R12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R12B Gene

Cytoplasm. Note=Along actomyosin filaments and stress fibers.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R12B Gene COMPARTMENTS Subcellular localization image for PPP1R12B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PPP1R12B: view

Pathways & Interactions for PPP1R12B Gene

genes like me logo Genes that share pathways with PPP1R12B: view

Interacting Proteins for PPP1R12B Gene

SIGNOR curated interactions for PPP1R12B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PPP1R12B: view

Drugs & Compounds for PPP1R12B Gene

No Compound Related Data Available

Transcripts for PPP1R12B Gene

Unigene Clusters for PPP1R12B Gene

Protein phosphatase 1, regulatory subunit 12B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:

ExUns: 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PPP1R12B Gene

GeneLoc Exon Structure for
PPP1R12B
ECgene alternative splicing isoforms for
PPP1R12B

Expression for PPP1R12B Gene

mRNA expression in normal human tissues for PPP1R12B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R12B Gene

This gene is overexpressed in Artery - Tibial (x4.2), Heart - Left Ventricle (x4.1), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for PPP1R12B Gene

This gene is overexpressed in Seminal vesicle (10.8), Uterus (8.0), Colon (7.4), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PPP1R12B Gene



SOURCE GeneReport for Unigene cluster for PPP1R12B Gene Hs.444403

mRNA Expression by UniProt/SwissProt for PPP1R12B Gene

O60237-MYPT2_HUMAN
Tissue specificity: Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific.
genes like me logo Genes that share expression patterns with PPP1R12B: view

Protein tissue co-expression partners for PPP1R12B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPP1R12B Gene

Orthologs for PPP1R12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R12B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPP1R12B 35
  • 87.36 (n)
  • 87.97 (a)
PPP1R12B 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R12B 35
  • 99.59 (n)
  • 99.69 (a)
PPP1R12B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R12B 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R12B 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r12b 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R12B 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749340 35
  • 70.53 (n)
  • 71.33 (a)
PPP1R12B 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R12B 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP1R12B 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mbs 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
Species with no ortholog for PPP1R12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R12B Gene

ENSEMBL:
Gene Tree for PPP1R12B (if available)
TreeFam:
Gene Tree for PPP1R12B (if available)

Paralogs for PPP1R12B Gene

Paralogs for PPP1R12B Gene

Pseudogenes.org Pseudogenes for PPP1R12B Gene

genes like me logo Genes that share paralogs with PPP1R12B: view

Variants for PPP1R12B Gene

Sequence variations from dbSNP and Humsavar for PPP1R12B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2843414 - 202,425,568(+) TAGGA(A/G)TTGAT reference, missense
rs3881953 - 202,558,893(-) TTCTA(A/C/G/T)GTAAG reference, missense
rs497824 -- 202,556,182(+) AATAC(A/G)ATATT intron-variant
rs511705 -- 202,552,529(+) GGGTC(C/G)TTGCT intron-variant
rs605316 -- 202,546,532(+) tcagg(A/G)ggtcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R12B Gene

Variant ID Type Subtype PubMed ID
dgv517n71 CNV Gain 21882294
esv29503 CNV Loss 19812545
dgv96n67 CNV Loss 20364138
nsv433192 CNV Loss 18776910
esv1009152 CNV Gain 20482838
esv2721584 CNV Deletion 23290073
esv2027802 CNV Deletion 18987734
esv2721595 CNV Deletion 23290073
nsv159751 CNV Loss 16902084
nsv514037 CNV Gain 21397061
dgv97n67 CNV Loss 20364138
esv24486 CNV Loss 19812545
nsv514038 CNV Gain 21397061
nsv873106 CNV Loss 21882294
esv2721606 CNV Deletion 23290073
esv2379385 CNV Deletion 18987734
esv2673485 CNV Deletion 23128226
esv8498 CNV Loss 19470904
esv1006468 CNV Deletion 20482838
nsv471538 CNV Duplication 19718026
nsv873107 CNV Gain 21882294
nsv516501 CNV Gain 19592680
nsv832337 CNV Loss 17160897

Variation tolerance for PPP1R12B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R12B Gene

Disorders for PPP1R12B Gene

Relevant External Links for PPP1R12B

Genetic Association Database (GAD)
PPP1R12B
Human Genome Epidemiology (HuGE) Navigator
PPP1R12B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R12B

No disorders were found for PPP1R12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R12B Gene

Publications for PPP1R12B Gene

  1. A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. (PMID: 9570949) Fujioka M. … Ito M. (Genomics 1998) 2 3 4 67
  2. The major myosin phosphatase in skeletal muscle is a complex between the beta-isoform of protein phosphatase 1 and the MYPT2 gene product. (PMID: 9827534) Moorhead G. … Cohen P. (FEBS Lett. 1998) 3 23
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PPP1R12B Gene

Sources for PPP1R12B Gene

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