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Aliases for PPP1R11 Gene

Aliases for PPP1R11 Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 11 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 11 2 3
  • Hemochromatosis Candidate Gene V Protein 3 4
  • Protein Phosphatase Inhibitor 3 3 4
  • HCG V 3 4
  • TCTE5 3 4
  • HCGV 3 4
  • T-Complex-Associated-Testis-Expressed 5 3
  • Inhibitor-3 3
  • CFAP255 3
  • TCTEX5 3
  • HCG-V 3
  • IPP3 3

External Ids for PPP1R11 Gene

Previous HGNC Symbols for PPP1R11 Gene

  • TCTE5

Previous GeneCards Identifiers for PPP1R11 Gene

  • GC06P030090
  • GC06P029805
  • GC06P030141
  • GC06P030142
  • GC06P030037
  • GC06P030038
  • GC06P030047
  • GC06P030192
  • GC06P030242
  • GC06P030272

Summaries for PPP1R11 Gene

Entrez Gene Summary for PPP1R11 Gene

  • This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1R11 Gene

PPP1R11 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 11) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R11 Gene

  • Inhibitor of protein phosphatase 1.

Gene Wiki entry for PPP1R11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R11 Gene

Genomics for PPP1R11 Gene

Regulatory Elements for PPP1R11 Gene

Enhancers for PPP1R11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R11 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R11 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R11 Gene

Chromosome:
6
Start:
30,066,709 bp from pter
End:
30,070,333 bp from pter
Size:
3,625 bases
Orientation:
Plus strand

Genomic View for PPP1R11 Gene

Genes around PPP1R11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PPP1R11 Gene

  • Protein details for PPP1R11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60927-PP1RB_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 11
    Protein Accession:
    O60927

    Protein attributes for PPP1R11 Gene

    Size:
    126 amino acids
    Molecular mass:
    13953 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R11 Gene

Proteomics data for PPP1R11 Gene at MOPED

Post-translational modifications for PPP1R11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R11 Gene

No data available for DME Specific Peptides for PPP1R11 Gene

Domains & Families for PPP1R11 Gene

Gene Families for PPP1R11 Gene

Protein Domains for PPP1R11 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R11: view

No data available for UniProtKB/Swiss-Prot for PPP1R11 Gene

Function for PPP1R11 Gene

Molecular function for PPP1R11 Gene

GENATLAS Biochemistry:
protein phosphatase 1,regulatory (inhibitor) subunit 11,t-complex associated, expressed in testis,mouse Tctex 5 homolog,with a calculator mass of 14kDa and an apparent mass of 23kDa
UniProtKB/Swiss-Prot Function:
Inhibitor of protein phosphatase 1.
genes like me logo Genes that share phenotypes with PPP1R11: view

Animal Model Products

CRISPR Products

miRNA for PPP1R11 Gene

miRTarBase miRNAs that target PPP1R11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R11 Gene

Localization for PPP1R11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R11 Gene COMPARTMENTS Subcellular localization image for PPP1R11 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R11 Gene

Pathways & Interactions for PPP1R11 Gene

genes like me logo Genes that share pathways with PPP1R11: view

Pathways by source for PPP1R11 Gene

Gene Ontology (GO) - Biological Process for PPP1R11 Gene

None

No data available for SIGNOR curated interactions for PPP1R11 Gene

Drugs & Compounds for PPP1R11 Gene

No Compound Related Data Available

Transcripts for PPP1R11 Gene

mRNA/cDNA for PPP1R11 Gene

(10) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R11 Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R11 Gene

No ASD Table

Relevant External Links for PPP1R11 Gene

GeneLoc Exon Structure for
PPP1R11
ECgene alternative splicing isoforms for
PPP1R11

Expression for PPP1R11 Gene

mRNA expression in normal human tissues for PPP1R11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7) and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R11 Gene



SOURCE GeneReport for Unigene cluster for PPP1R11 Gene Hs.82887

mRNA Expression by UniProt/SwissProt for PPP1R11 Gene

O60927-PP1RB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPP1R11: view

Protein tissue co-expression partners for PPP1R11 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PPP1R11 Gene

Orthologs for PPP1R11 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R11 35
  • 94.18 (n)
  • 96.03 (a)
PPP1R11 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R11 35
  • 92.33 (n)
  • 96.03 (a)
PPP1R11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r11 35
  • 85.71 (n)
  • 88.1 (a)
Ppp1r11 16
Ppp1r11 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R11 35
  • 99.74 (n)
  • 100 (a)
PPP1R11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r11 35
  • 90.74 (n)
  • 96.03 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R11 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R11 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r11 35
  • 62.85 (n)
  • 65.62 (a)
Str.2226 35
zebrafish
(Danio rerio)
Actinopterygii ppp1r11 35
  • 69.82 (n)
  • 81.08 (a)
wufj64e04 35
ppp1r11 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13994 36
  • 26 (a)
OneToMany
I-3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5351 36
  • 35 (a)
OneToOne
Species with no ortholog for PPP1R11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R11 Gene

ENSEMBL:
Gene Tree for PPP1R11 (if available)
TreeFam:
Gene Tree for PPP1R11 (if available)

Paralogs for PPP1R11 Gene

Pseudogenes.org Pseudogenes for PPP1R11 Gene

genes like me logo Genes that share paralogs with PPP1R11: view

No data available for Paralogs for PPP1R11 Gene

Variants for PPP1R11 Gene

Sequence variations from dbSNP and Humsavar for PPP1R11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1150738 -- 30,067,312(-) TCAGA(G/T)TGGTA intron-variant, utr-variant-5-prime
rs2074482 -- 30,068,694(-) CATTT(G/T)GATGA reference, synonymous-codon
rs11754711 -- 30,066,483(+) AGAGA(A/C)CGAAT upstream-variant-2KB
rs11755907 -- 30,067,730(+) TGGTT(A/T)TGTGT intron-variant
rs9261280 -- 30,066,407(+) GTGCA(C/T)ATATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R11 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073
nsv884049 CNV Loss 21882294

Variation tolerance for PPP1R11 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R11 Gene

Disorders for PPP1R11 Gene

Relevant External Links for PPP1R11

Genetic Association Database (GAD)
PPP1R11
Human Genome Epidemiology (HuGE) Navigator
PPP1R11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R11

No disorders were found for PPP1R11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R11 Gene

Publications for PPP1R11 Gene

  1. Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. (PMID: 9843442) Zhang J. … Lee E.Y.C. (Biochemistry 1998) 2 3 4 23 67
  2. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. (PMID: 8781118) Giffon T. … David V. (Immunogenetics 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PPP1R11 Gene

Sources for PPP1R11 Gene

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