Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R11 Gene

Aliases for PPP1R11 Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 11 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 11 2 3
  • Hemochromatosis Candidate Gene V Protein 3 4
  • Protein Phosphatase Inhibitor 3 3 4
  • HCG V 3 4
  • TCTE5 3 4
  • HCGV 3 4
  • Protein Phosphatase 1 Regulatory Subunit 11 3
  • T-Complex-Associated-Testis-Expressed 5 3
  • Inhibitor-3 3
  • CFAP255 3
  • TCTEX5 3
  • HCG-V 3
  • IPP3 3

External Ids for PPP1R11 Gene

Previous HGNC Symbols for PPP1R11 Gene

  • TCTE5

Previous GeneCards Identifiers for PPP1R11 Gene

  • GC06P030090
  • GC06P029805
  • GC06P030141
  • GC06P030142
  • GC06P030037
  • GC06P030038
  • GC06P030047
  • GC06P030192
  • GC06P030242
  • GC06P030272
  • GC06P030362
  • GC06P030512

Summaries for PPP1R11 Gene

Entrez Gene Summary for PPP1R11 Gene

  • This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1R11 Gene

PPP1R11 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 11) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R11 Gene

  • Inhibitor of protein phosphatase 1.

Gene Wiki entry for PPP1R11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R11 Gene

Genomics for PPP1R11 Gene

Regulatory Elements for PPP1R11 Gene

Enhancers for PPP1R11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F030094 1.2 Ensembl ENCODE 10.7 +28.7 28710 1.6 ELF3 CBX3 MLX ARID4B THRB ZNF48 ZSCAN9 RARA FOS CREM HLA-U HLA-K HCG4 ZFP57 PPP1R11 HLA-W TRIM31-AS1 RNF39
GH06F030527 1.7 FANTOM5 Ensembl ENCODE 3.5 +462.4 462392 3.8 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 PRR3 ABCF1 HCG18 PPP1R10 IER3 DHX16 MICD GNL1 GTF2H4 HLA-C
GH06F030507 1.5 FANTOM5 Ensembl ENCODE 3.8 +443.0 442992 5.8 HDGF PKNOX1 TBL1XR1 ZBTB40 YY1 ZNF121 ELK1 CBX5 SCRT2 ETV6 TRIM39-RPP21 ABCF1 HLA-A PPP1R10 TRIM39 HLA-E TRIM26 ENSG00000199332 POU5F1 PPP1R11
GH06F029963 1.8 FANTOM5 Ensembl ENCODE 2.7 -100.5 -100460 4.8 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 HLA-A HLA-W HLA-K MICD HLA-H HLA-J HCG4P5 HCG4 IFITM4P ABCF1
GH06F030100 1.7 FANTOM5 Ensembl ENCODE 2.5 +35.4 35372 3.9 MLX WRNIP1 ARID4B DMAP1 SLC30A9 ZNF143 ZNF263 SP3 SP5 ZHX2 HLA-K RPL23AP1 TRIM31-AS1 HCG4 MICD ZNRD1ASP ETF1P1 PPP1R10 HCG18 PAIP1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R11 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000487591 491 2001 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1

Genomic Location for PPP1R11 Gene

Chromosome:
6
Start:
30,066,709 bp from pter
End:
30,070,333 bp from pter
Size:
3,625 bases
Orientation:
Plus strand

Genomic View for PPP1R11 Gene

Genes around PPP1R11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PPP1R11 Gene

  • Protein details for PPP1R11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60927-PP1RB_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 11
    Protein Accession:
    O60927

    Protein attributes for PPP1R11 Gene

    Size:
    126 amino acids
    Molecular mass:
    13953 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R11 Gene

Post-translational modifications for PPP1R11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R11 Gene

No data available for DME Specific Peptides for PPP1R11 Gene

Domains & Families for PPP1R11 Gene

Gene Families for PPP1R11 Gene

Protein Domains for PPP1R11 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R11: view

No data available for UniProtKB/Swiss-Prot for PPP1R11 Gene

Function for PPP1R11 Gene

Molecular function for PPP1R11 Gene

GENATLAS Biochemistry:
protein phosphatase 1,regulatory (inhibitor) subunit 11,t-complex associated, expressed in testis,mouse Tctex 5 homolog,with a calculator mass of 14kDa and an apparent mass of 23kDa
UniProtKB/Swiss-Prot Function:
Inhibitor of protein phosphatase 1.

Gene Ontology (GO) - Molecular Function for PPP1R11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0004865 protein serine/threonine phosphatase inhibitor activity IBA --
GO:0005515 protein binding IPI 9843442
genes like me logo Genes that share ontologies with PPP1R11: view
genes like me logo Genes that share phenotypes with PPP1R11: view

Animal Model Products

miRNA for PPP1R11 Gene

miRTarBase miRNAs that target PPP1R11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R11 Gene

Localization for PPP1R11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R11 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PPP1R11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with PPP1R11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R11 Gene

Pathways & Interactions for PPP1R11 Gene

genes like me logo Genes that share pathways with PPP1R11: view

Pathways by source for PPP1R11 Gene

Gene Ontology (GO) - Biological Process for PPP1R11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032515 negative regulation of phosphoprotein phosphatase activity IBA --
genes like me logo Genes that share ontologies with PPP1R11: view

No data available for SIGNOR curated interactions for PPP1R11 Gene

Transcripts for PPP1R11 Gene

mRNA/cDNA for PPP1R11 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R11 Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R11 Gene

No ASD Table

Relevant External Links for PPP1R11 Gene

GeneLoc Exon Structure for
PPP1R11
ECgene alternative splicing isoforms for
PPP1R11

Expression for PPP1R11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7) and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R11 Gene



Protein tissue co-expression partners for PPP1R11 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R11 Gene:

PPP1R11

SOURCE GeneReport for Unigene cluster for PPP1R11 Gene:

Hs.82887

mRNA Expression by UniProt/SwissProt for PPP1R11 Gene:

O60927-PP1RB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPP1R11: view

Primer Products

No data available for mRNA differential expression in normal tissues for PPP1R11 Gene

Orthologs for PPP1R11 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R11 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia PPP1R11 34 35
  • 94.18 (n)
dog
(Canis familiaris)
Mammalia PPP1R11 34 35
  • 92.33 (n)
rat
(Rattus norvegicus)
Mammalia Ppp1r11 34
  • 90.74 (n)
mouse
(Mus musculus)
Mammalia Ppp1r11 34 16 35
  • 85.71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R11 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R11 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r11 34
  • 62.85 (n)
Str.2226 34
zebrafish
(Danio rerio)
Actinopterygii ppp1r11 34 35
  • 69.82 (n)
wufj64e04 34
fruit fly
(Drosophila melanogaster)
Insecta CG13994 35
  • 26 (a)
OneToMany
I-3 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5351 35
  • 35 (a)
OneToOne
Species where no ortholog for PPP1R11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R11 Gene

ENSEMBL:
Gene Tree for PPP1R11 (if available)
TreeFam:
Gene Tree for PPP1R11 (if available)

Paralogs for PPP1R11 Gene

Pseudogenes.org Pseudogenes for PPP1R11 Gene

genes like me logo Genes that share paralogs with PPP1R11: view

No data available for Paralogs for PPP1R11 Gene

Variants for PPP1R11 Gene

Sequence variations from dbSNP and Humsavar for PPP1R11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1051133 -- 30,070,131(+) CTCTT(A/T)CCTCT downstream-variant-500B, utr-variant-3-prime
rs111319301 -- 30,068,474(+) CTGGT(A/G)CTATG intron-variant
rs111327592 -- 30,064,994(+) AAGGG(A/G)GAAAA downstream-variant-500B, upstream-variant-2KB
rs111785008 -- 30,070,590(+) AAAGA(-/G)GTACA downstream-variant-500B, utr-variant-3-prime
rs113784066 -- 30,070,466(+) TTTCC(A/G)TGAGT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP1R11 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv601264 CNV loss 21841781
nsv1144137 CNV deletion 24896259
nsv1122126 CNV deletion 24896259

Variation tolerance for PPP1R11 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R11 Gene

Disorders for PPP1R11 Gene

Relevant External Links for PPP1R11

Genetic Association Database (GAD)
PPP1R11
Human Genome Epidemiology (HuGE) Navigator
PPP1R11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R11

No disorders were found for PPP1R11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R11 Gene

Publications for PPP1R11 Gene

  1. Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. (PMID: 9843442) Zhang J. … Lee E.Y.C. (Biochemistry 1998) 2 3 4 22 64
  2. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. (PMID: 8781118) Giffon T. … David V. (Immunogenetics 1996) 2 3 4 64
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for PPP1R11 Gene

Sources for PPP1R11 Gene

Content
Loading form....