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Aliases for PPP1R10 Gene

Aliases for PPP1R10 Gene

  • Protein Phosphatase 1 Regulatory Subunit 10 2 3 5
  • Phosphatase 1 Nuclear Targeting Subunit 2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 2 3
  • MHC Class I Region Proline-Rich Protein CAT53 3 4
  • Protein Phosphatase 1, Regulatory Subunit 10 2 3
  • HLA-C Associated Transcript 53 2 3
  • PP1-Binding Protein Of 114 KDa 3 4
  • CAT53 3 4
  • PNUTS 3 4
  • FB19 3 4
  • P99 3 4
  • Testis Tissue Sperm-Binding Protein Li 67n 3
  • Protein FB19 4
  • PP1R10 3
  • R111 3

External Ids for PPP1R10 Gene

Previous GeneCards Identifiers for PPP1R10 Gene

  • GC06M030623
  • GC06M030338
  • GC06M030674
  • GC06M030677

Summaries for PPP1R10 Gene

Entrez Gene Summary for PPP1R10 Gene

  • This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PPP1R10 Gene

PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and ERK Signaling. GO annotations related to this gene include poly(A) RNA binding and protein phosphatase inhibitor activity. An important paralog of this gene is PRR3.

UniProtKB/Swiss-Prot for PPP1R10 Gene

  • Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Gene Wiki entry for PPP1R10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R10 Gene

Genomics for PPP1R10 Gene

Regulatory Elements for PPP1R10 Gene

Promoters for PPP1R10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R10 Gene

Chromosome:
6
Start:
30,600,400 bp from pter
End:
30,618,612 bp from pter
Size:
18,213 bases
Orientation:
Minus strand

Genomic View for PPP1R10 Gene

Genes around PPP1R10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PPP1R10 Gene

  • Protein details for PPP1R10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QC0-PP1RA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 1 regulatory subunit 10
    Protein Accession:
    Q96QC0
    Secondary Accessions:
    • O00405

    Protein attributes for PPP1R10 Gene

    Size:
    940 amino acids
    Molecular mass:
    99058 Da
    Quaternary structure:
    • Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).

neXtProt entry for PPP1R10 Gene

Proteomics data for PPP1R10 Gene at MOPED

Post-translational modifications for PPP1R10 Gene

  • Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
  • Ubiquitination at Lys 13 and Lys 33
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1R10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP1R10 (PNUTS)

No data available for DME Specific Peptides for PPP1R10 Gene

Domains & Families for PPP1R10 Gene

Gene Families for PPP1R10 Gene

Protein Domains for PPP1R10 Gene

Suggested Antigen Peptide Sequences for PPP1R10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QC0

UniProtKB/Swiss-Prot:

PP1RA_HUMAN :
  • Contains 1 TFIIS N-terminal domain.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • Contains 1 TFIIS N-terminal domain.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with PPP1R10: view

Function for PPP1R10 Gene

Molecular function for PPP1R10 Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PPP1R10: view
genes like me logo Genes that share phenotypes with PPP1R10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R10 Gene

Localization for PPP1R10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R10 Gene

Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R10 Gene COMPARTMENTS Subcellular localization image for PPP1R10 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PPP1R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
genes like me logo Genes that share ontologies with PPP1R10: view

Pathways & Interactions for PPP1R10 Gene

genes like me logo Genes that share pathways with PPP1R10: view

Pathways by source for PPP1R10 Gene

Interacting Proteins for PPP1R10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365694%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: Q96QC0-PP1RA_HUMAN ENSP00000365694 for PPP1R10 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for PPP1R10 Gene

None

No data available for SIGNOR curated interactions for PPP1R10 Gene

Drugs & Compounds for PPP1R10 Gene

(2) Drugs for PPP1R10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R10: view

Transcripts for PPP1R10 Gene

Unigene Clusters for PPP1R10 Gene

Protein phosphatase 1, regulatory subunit 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R10 Gene

No ASD Table

Relevant External Links for PPP1R10 Gene

GeneLoc Exon Structure for
PPP1R10
ECgene alternative splicing isoforms for
PPP1R10

Expression for PPP1R10 Gene

mRNA expression in normal human tissues for PPP1R10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R10 Gene

This gene is overexpressed in Cervix (21.4), Peripheral blood mononuclear cells (11.0), and Breast (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R10 Gene



SOURCE GeneReport for Unigene cluster for PPP1R10 Gene Hs.106019

mRNA Expression by UniProt/SwissProt for PPP1R10 Gene

Q96QC0-PP1RA_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with PPP1R10: view

Protein tissue co-expression partners for PPP1R10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP1R10 Gene

Orthologs for PPP1R10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R10 35
  • 88.93 (n)
  • 94.57 (a)
PPP1R10 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R10 35
  • 92.02 (n)
  • 96.17 (a)
PPP1R10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r10 35
  • 86.11 (n)
  • 93.13 (a)
Ppp1r10 16
Ppp1r10 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R10 35
  • 99.5 (n)
  • 99.57 (a)
PPP1R10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r10 35
  • 84.98 (n)
  • 91.97 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R10 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PPP1R10 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10280 35
zebrafish
(Danio rerio)
Actinopterygii ppp1r10 35
  • 63.68 (n)
  • 65.87 (a)
ppp1r10 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta PNUTS 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8858 36
  • 25 (a)
OneToMany
Species with no ortholog for PPP1R10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R10 Gene

ENSEMBL:
Gene Tree for PPP1R10 (if available)
TreeFam:
Gene Tree for PPP1R10 (if available)

Paralogs for PPP1R10 Gene

Paralogs for PPP1R10 Gene

Pseudogenes.org Pseudogenes for PPP1R10 Gene

genes like me logo Genes that share paralogs with PPP1R10: view

Variants for PPP1R10 Gene

Sequence variations from dbSNP and Humsavar for PPP1R10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16897725 - 30,606,584(+) AAGGT(C/G)GCTCA nc-transcript-variant, reference, missense
rs1052945 -- 30,602,025(-) AGGGC(A/C/T)GCCAC nc-transcript-variant, reference, missense
rs1264419 -- 30,609,004(-) TTCCT(C/G)GGTCA intron-variant
rs1264420 -- 30,607,826(-) CCACT(C/T)CTGCT intron-variant
rs1264421 -- 30,605,736(-) ACTAC(A/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R10 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv884091 CNV Loss 21882294
nsv5244 CNV Loss 18451855
nsv830626 CNV Loss 17160897

Variation tolerance for PPP1R10 Gene

Residual Variation Intolerance Score: 3.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R10 Gene

HapMap Linkage Disequilibrium report
PPP1R10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R10 Gene

Disorders for PPP1R10 Gene

Relevant External Links for PPP1R10

Genetic Association Database (GAD)
PPP1R10
Human Genome Epidemiology (HuGE) Navigator
PPP1R10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R10

No disorders were found for PPP1R10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R10 Gene

Publications for PPP1R10 Gene

  1. Cloning of a new gene (FB19) within HLA class I region. (PMID: 9784381) Totaro A. … Gasparini P. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. (PMID: 20372802) De Leon G. … Krucher N.A. (Int. J. Oncol. 2010) 3 23
  3. Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis. (PMID: 18360108) De Leon G. … Krucher N.A. (Cancer Biol. Ther. 2008) 3 23
  4. Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. (PMID: 17318220) Lee S.J. … Kwon Y.G. (Cell Death Differ. 2007) 3 23
  5. CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. (PMID: 15894402) Raha-Chowdhury R. … Gruen J.R. (Brain Res. Mol. Brain Res. 2005) 3 23

Products for PPP1R10 Gene

Sources for PPP1R10 Gene

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