Aliases for PPP1CC Gene
- Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme 2 3
- Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform 2 3
- Protein Phosphatase 1C Catalytic Subunit 3 4
- EC 188.8.131.52 4 63
- PP-1G 3 4
- Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit 3
- Serine/Threonine Phosphatase 1 Gamma 3
- PPP1G 3
- PP1C 3
External Ids for PPP1CC Gene
Previous GeneCards Identifiers for PPP1CC Gene
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for PPP1CC Gene
PPP1CC (Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include protein kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is PPP1CA.
UniProtKB/Swiss-Prot for PPP1CC Gene
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.