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PPP1CC Gene

protein-coding   GIFtS: 71
GCID: GC12M111157

Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme

(Previous names: protein phosphatase 1, catalytic subunit, gamma isoform)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme1 2     PP1C2
Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform1 2     PPP1G2
Protein Phosphatase 1C Catalytic Subunit2 3     Serine/Threonine Phosphatase 1 Gamma2
PP-1G2 3     Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit2
EC 3.1.3.163 8     

External Ids:    HGNC: 92831   Entrez Gene: 55012   Ensembl: ENSG000001862987   OMIM: 1769145   UniProtKB: P368733   

Export aliases for PPP1CC gene to outside databases

Previous GC identifers: GC12M116400 GC12M9F0150 GC12M109620 GC12M108174


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1CC Gene:
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous
serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in
mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization
patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for PPP1CC Gene:
PPP1CC (protein phosphatase 1, catalytic subunit, gamma isozyme) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is PPP1CB.

UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for
cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein
synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic
plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic
density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex,
which plays a role in the control of chromatin structure and cell cycle progression during the transition from
mitosis into interphase

summary for PPP1CC Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP1CC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1CC gene promoter:
         STAT5B   E2F-5   Spz1   AP-4   GATA-2   FAC1   HSF2   c-Myb   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1CC promoter sequence
   Search Chromatin IP Primers for PPP1CC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1CC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1-q24.2   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.1-q24.2

PPP1CC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1CC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M111157:  view genomic region     (about GC identifiers)

Start:
111,157,485 bp from pter      End:
111,180,783 bp from pter
Size:
23,299 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit  
Size: 323 amino acids; 36984 Da
Cofactor: Binds 1 iron ion per subunit
Cofactor: Binds 1 manganese ion per subunit
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by
inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory
subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in
liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with cyanobacterial toxin
microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform gamma-2 interacts with SPZ1 (By
similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC,
HCFC1, ACTB and OGT. Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex
containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric
heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with PPP1R42;
the interaction is direct (By similarity). Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase
complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts
with isoform 1 and isoform 4 NEK2. Interacts with URI1; the interaction is phosphorylation-dependent and occurs
in a growth factor-dependent manner
Miscellaneous: Microcystin toxin is bound to Cys-273 through a thioether bond
5 PDB 3D structures from and Proteopedia for PPP1CC:
1IT6 (3D)        1JK7 (3D)        1U32 (3D)        2BCD (3D)        2BDX (3D)    
Alternative splicing: 2 isoforms:  P36873-1   P36873-2   

Explore the universe of human proteins at neXtProt for PPP1CC: NX_P36873

Explore proteomics data for PPP1CC at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK21
  • Ubiquitination2 at Lys6, Lys26, Lys98, Lys113, Lys141, Lys147, Lys150, Lys168, Lys238, Lys260
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP1CC (P36873) (see all 23)
     PGKNVQL  RPTDVPD  RPVTPPR  CGDIHGQ 


    See PPP1CC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231903.1  NP_002701.1  

    ENSEMBL proteins: 
     ENSP00000335084   ENSP00000341779   ENSP00000447528   ENSP00000447090   ENSP00000447122  
     ENSP00000448981   ENSP00000448437  
    Reactome Protein details: P36873

    PPP1CC Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PPP1CC
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    OriGene Custom Protein Services for PPP1CC
    GenScript Custom Purified and Recombinant Proteins Services for PPP1CC
    Novus Biologicals PPP1CC Proteins
    Novus Biologicals PPP1CC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPP1CC

     
    Search eBioscience for Proteins for PPP1CC 

     
    antibodies-online proteins for PPP1CC (13 products) 

     
    antibodies-online peptides for PPP1CC

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    ThermoFisher Antibody for PPP1CC
    antibodies-online antibodies for PPP1CC (58 products) 

    PPP1CC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PPP1CC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPP1CC
    Cloud-Clone Corp. CLIAs for PPP1CC
    Search eBioscience for ELISAs for PPP1CC 
    antibodies-online kits for PPP1CC (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P36873

    ProtoNet protein and cluster: P36873

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    Find genes that share domains with PPP1CC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP1G_HUMAN, P36873
    Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
    holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for
    cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein
    synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic
    plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic
    density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex,
    which plays a role in the control of chromatin structure and cell cycle progression during the transition from
    mitosis into interphase
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Enzyme regulation: Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward
    EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress

         Genatlas biochemistry entry for PPP1CC:
    serine/threonine protein phosphatase 1,catalytic subunit,gamma,involved in cell division and glycogen
    metabolism,expressed in skeletal muscle

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS--
    GO:0004722protein serine/threonine phosphatase activity IMP10880350
    GO:0005515protein binding IPI10807923
    GO:0016787hydrolase activity ----
    GO:0019901protein kinase binding IPI10880350
         
    Find genes that share ontologies with PPP1CC           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PPP1CC:
     Decreased TP53 protein express  Decreased focal adhesion (FA)   Increased apoptosis  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppp1cc):
     embryogenesis  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with PPP1CC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppp1cctm1Var for PPP1CC

       genOway: Develop your customized and physiologically relevant rodent model for PPP1CC

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP1CC:
    hsa-mir-940 (MIRT036628), hsa-mir-92a-3p (MIRT049174), hsa-mir-30a-5p (MIRT028665), hsa-mir-26a-5p (MIRT050065), hsa-mir-26b-5p (MIRT050049), hsa-mir-15b-5p (MIRT046498), hsa-mir-185-5p (MIRT045316)

    Block miRNA regulation of human, mouse, rat PPP1CC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1CC (see all 38):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-323-3p hsa-miR-188-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-218 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPPP1CC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1CC

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    Clone
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    GenScript: all cDNA clones in your preferred vector: PPP1CC (NM_002710)
    Sino Biological Human cDNA Clone for PPP1CC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1CC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CC
    Addgene plasmids for PPP1CC 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP1G_HUMAN, P36873: Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome,
    centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By
    similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and
    cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting
    subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting
    to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at
    kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from
    early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    cytoskeleton2
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA11739654
    GO:0005730nucleolus IDA11739654
    GO:0005737cytoplasm IDA11739654
    GO:0005739mitochondrion IDA17936702

    Find genes that share ontologies with PPP1CC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1CC About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF20.47
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    2Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with PPP1CC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for PPP1CC
        Insulin Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PPP1CC (see all 6)
        Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Transcription CREB pathway
    Translation Regulation of EIF2 activity
    Signal transduction Calcium signaling

    2 BioSystems Pathways for PPP1CC
        Insulin-mediated glucose transport
    Aurora B signaling


    5 Reactome Pathways for PPP1CC
        Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
    Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Downregulation of TGF-beta receptor signaling


    Selected Kegg Pathways  (Kegg details for PPP1CC) (see all 16):
        mRNA surveillance pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP1CC: 
              Polycomb & Trithorax Complexes in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP1CC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1CC (P368731, 2, 3 ENSP000003350844) via UniProtKB, MINT, STRING, and/or I2D (see all 774)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005977glycogen metabolic process IEA--
    GO:0006470protein dephosphorylation IEA--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0019433triglyceride catabolic process TAS--

    Find genes that share ontologies with PPP1CC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP1CC available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    6 HMDB Compounds for PPP1CC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    GlycogenAnimal starch (see all 5)9005-79-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 DrugBank Compounds for PPP1CC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    9,10-Deepithio-9,10-Didehydroacanthifolicin-- 78111-17-8target--17139284 17016423 10592235
    Calyculin A-- 101932-71-2target--17139284 17016423
    Motuporin-- --target--16343532
    (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID-- --target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1CC gene (2 alternative transcripts): 
    NM_001244974.1  NM_002710.3  

    Unigene Cluster for PPP1CC:

    Protein phosphatase 1, catalytic subunit, gamma isozyme
    Hs.79081  [show with all ESTs]
    Unigene Representative Sequence: NM_002710
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335007(uc021rdx.1 uc001tru.3) ENST00000340766 ENST00000550261
    ENST00000546904 ENST00000551582 ENST00000553024 ENST00000546933 ENST00000550991
    ENST00000551676 ENST00000551690
    miRNA
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    Block miRNA regulation of human, mouse, rat PPP1CC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1CC (see all 38):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-323-3p hsa-miR-188-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-218 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPPP1CC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP1CC
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    OriGene ORF clones in mouse, rat for PPP1CC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP1CC (NM_002710)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1CC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CC
    Addgene plasmids for PPP1CC 
    Primer
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    OriGene qPCR primer pairs and template standards for PPP1CC
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1CC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP1CC
      QuantiTect SYBR Green Assays in human, mouse, rat PPP1CC
      QuantiFast Probe-based Assays in human, mouse, rat PPP1CC

    Additional mRNA sequence: 

    AK091841.1 AK297882.1 BC014073.2 L07395.1 X74008.1 

    21 DOTS entries:

    DT.100651097  DT.454897  DT.95208381  DT.95374891  DT.92459097  DT.95374897  DT.100651083  DT.100873781 
    DT.100651087  DT.92459110  DT.100873780  DT.100651100  DT.92459098  DT.121161474  DT.100865667  DT.121161652 
    DT.101975787  DT.121161471  DT.121161680  DT.95374886  DT.95374887 

    Selected AceView cDNA sequences (see all 713):

    BG494400 AA329576 BQ425463 AA363832 BQ951434 AU127789 BE857343 BM673636 
    AK091841 CK300129 BU507626 AA319057 BU156646 CK429264 BM704365 BM466238 
    BM552097 AU131678 N91488 BG389563 BP370721 BM802741 AW575661 BM993194 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CC (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -     -                                                           -           -               
    SP2:                    -                                                                                       
    SP3:                                                                          -     -     -     -               
    SP4:              -                                                                                             
    SP5:                                                                                -                           


    ECgene alternative splicing isoforms for PPP1CC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPP1CC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCTTCTT
    PPP1CC Expression
    About this image

    PPP1CC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1CC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79081
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP1CC: 
              Polycomb & Trithorax Complexes in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1CC
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    QuantiFast Probe-based Assays in human, mouse, rat PPP1CC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP1CC gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1cc5
    Gm56011
    protein phosphatase 1, catalytic subunit, gamma isoform5
    predicted pseudogene 56011
    91.72(n)1
    99.68(a)1
      5 (62.20 cM)5
    4342331  XM_006508415.11  XP_006508478.11 
     1221582785 
    chicken
    (Gallus gallus)
    Aves PPP1CC1 protein phosphatase 1, catalytic subunit, gamma isozyme 87.72(n)
    99.07(a)
      416872  NM_001006190.1  NP_001006190.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1CC6
    protein phosphatase 1, catalytic subunit, gamma is...
    97(a)
    1 ↔ 1
    GL343423.1(393055-421796)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054188.12   -- 79.4(n)    BC054188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.34772 Danio rerio cDNA clone MGC55744 IMAGE3816387, complete more 80(n)    BC045444.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pp1-87B1 , 3 adult locomotory behavior protein
    serine/threonine more3
    Protein phosphatase 1 at 87B1
    93(a)
    (best of 10)3
    72.24(n)1
    93.31(a)1
      492601  NM_080198.31  NP_524937.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F52H3.63 serine/threonine specific protein
    phosphatase
    55(a)
    (best of 28)
      II(10026560-10027773)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPZ2(YDR436W)4 Serine/threonine protein phosphatase Z, isoform of more   --   4(1334821-1336953) 852046  NP_010724.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOPP41 TOPP4 68.45(n)
    78.93(a)
      818571  NM_129543.2  NP_181514.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02680001 Os03g0268000 69.57(n)
    82.61(a)
      4332369  NM_001056204.1  NP_001049669.1 


    ENSEMBL Gene Tree for PPP1CC (if available)
    TreeFam Gene Tree for PPP1CC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1CC gene
    PPP1CB2  PPP1CA2  
    10 SIMAP similar genes for PPP1CC using alignment to 7 protein entries:     PP1G_HUMAN (see all proteins):
    PPP1CA    PPP1CB    PPP2CB    PPP2CA    PPP6C    PPP3CC
    PPP4C    PPP3CA    PPP3CB    PPP5C

    Find genes that share paralogs with PPP1CC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1CC (see all 508)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396535891,2
    C--110955218(+) ACACAG/TATTAA 2 -- ds50010--------
    rs1498105781,2
    --110955316(+) GTATTA/GGTATC 2 -- ds50010--------
    rs1916756041,2
    --110955387(+) CGTGTA/GGTTTC 2 -- ut310--------
    rs1842398171,2
    --110955526(+) CCACAC/TGGTAT 2 -- ut310--------
    rs778322831,2
    C--110955725(+) GAACAA/GTATTG 3 T I ut31 mis10--------
    rs1900866951,2
    --110955878(+) TAATTA/GCTATT 2 -- ut31 int10--------
    rs10505871,2
    C,F,A,H--110955931(-) GTTGTA/GTACAC 2 -- ut31 int1 ese316Minor allele frequency- G:0.13NS EA NA MN WA CSA 1099
    rs115582361,2
    F--110955998(-) CTCTTC/TCCTAA 2 -- ut31 int1 ese30--------
    rs1854848841,2
    --110956050(+) CGGTCA/GGGGAA 2 -- ut31 int10--------
    rs2000835861,2
    --110956054(+) CGGGG-/AAAAGTG 2 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for PPP1CC (111157485 - 111180783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PPP1CC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675965CNV Deletion23128226
    esv2657045CNV Deletion23128226
    nsv525818CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1CC
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1CC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 176914    OMIM disorders: --


    Find genes that share disorders with PPP1CC           About GenesLikeMe

    Genetic Association Database (GAD): PPP1CC
    Human Genome Epidemiology (HuGE) Navigator: PPP1CC (1 document)

    Export disorders for PPP1CC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1CC gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with PPP1CC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. (PubMed id 8394140)1, 2, 9 Barker H.M.... Cohen P.T.W. (Biochim. Biophys. Acta 1993)
    2. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H.... Skalnik D.G. (J. Biol. Chem. 2010)
    3. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PubMed id 19369647)1, 4 Kuzmin A....Varmuza S. (Biol. Reprod. 2009)
    4. NOM1 targets protein phosphatase I to the nucleolus. (PubMed id 17965019)1, 2 Gunawardena S.R.... Conklin K.F. (J. Biol. Chem. 2008)
    5. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PubMed id 17936702)1, 2 Djouder N.... Krek W. (Mol. Cell 2007)
    6. Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. (PubMed id 16343532)1, 7 Maynes J.T....James M.N. (J. Mol. Biol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PubMed id 12226088)1, 2 Ceulemans H....Bollen M. (J. Biol. Chem. 2002)
    9. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PubMed id 11564868)1, 2 Connor J.H.... Shenolikar S. (Mol. Cell. Biol. 2001)
    10. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. (PubMed id 11739654)1, 2 Trinkle-Mulcahy L.... Lamond A.I. (J. Cell Sci. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5501 HGNC: 9283 AceView: PPP1CC Ensembl:ENSG00000186298 euGenes: HUgn5501
    ECgene: PPP1CC Kegg: 5501 H-InvDB: PPP1CC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP1CC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1CC Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/032

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP1CC gene:
    Search GeneIP for patents involving PPP1CC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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