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Aliases for PPP1CC Gene

Aliases for PPP1CC Gene

  • Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform 2 3
  • Protein Phosphatase 1C Catalytic Subunit 3 4
  • EC 3.1.3.16 4 63
  • PP-1G 3 4
  • Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit 3
  • Serine/Threonine Phosphatase 1 Gamma 3
  • PPP1G 3
  • PP1C 3

External Ids for PPP1CC Gene

Previous GeneCards Identifiers for PPP1CC Gene

  • GC12M116400
  • GC12M9F0150
  • GC12M109620
  • GC12M111157
  • GC12M108174

Summaries for PPP1CC Gene

Entrez Gene Summary for PPP1CC Gene

  • The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1CC Gene

PPP1CC (Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include protein kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is PPP1CA.

UniProtKB/Swiss-Prot for PPP1CC Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CC Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP1CC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1CC Gene

Genomics for PPP1CC Gene

Regulatory Elements for PPP1CC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP1CC Gene

Start:
110,709,016 bp from pter
End:
110,742,978 bp from pter
Size:
33,963 bases
Orientation:
Minus strand

Genomic View for PPP1CC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1CC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CC Gene

Proteins for PPP1CC Gene

  • Protein details for PPP1CC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36873-PP1G_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    Protein Accession:
    P36873
    Secondary Accessions:

    Protein attributes for PPP1CC Gene

    Size:
    323 amino acids
    Molecular mass:
    36984 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform gamma-2 interacts with SPZ1 (By similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with PPP1R42; the interaction is direct (By similarity). Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with isoform 1 and isoform 4 NEK2. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with FOXP3.
    Miscellaneous:
    • Microcystin toxin is bound to Cys-273 through a thioether bond

    Three dimensional structures from OCA and Proteopedia for PPP1CC Gene

    Alternative splice isoforms for PPP1CC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CC Gene

Proteomics data for PPP1CC Gene at MOPED

Post-translational modifications for PPP1CC Gene

  • Phosphorylated by NEK2.
  • Ubiquitination at Lys6, Lys26, Lys98, Lys113, Lys141, Lys147, Lys150, Lys168, Lys238, and Lys260
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1CC Gene

Antibody Products

Domains for PPP1CC Gene

Gene Families for PPP1CC Gene

Graphical View of Domain Structure for InterPro Entry

P36873

UniProtKB/Swiss-Prot:

PP1G_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CC: view

Function for PPP1CC Gene

Molecular function for PPP1CC Gene

GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,gamma,involved in cell division and glycogen metabolism,expressed in skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Enzyme Numbers (IUBMB) for PPP1CC Gene

Gene Ontology (GO) - Molecular Function for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS --
GO:0004722 protein serine/threonine phosphatase activity IMP 10880350
GO:0005515 protein binding IPI 10807923
GO:0016787 hydrolase activity --
GO:0016791 phosphatase activity ISS --
genes like me logo Genes that share ontologies with PPP1CC: view
genes like me logo Genes that share phenotypes with PPP1CC: view

Animal Models for PPP1CC Gene

MGI Knock Outs for PPP1CC:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1CC

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PPP1CC Gene

Localization for PPP1CC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CC Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1CC Gene COMPARTMENTS Subcellular localization image for PPP1CC gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA 11739654
GO:0005730 nucleolus IDA 11739654
GO:0005737 cytoplasm IDA 11739654
genes like me logo Genes that share ontologies with PPP1CC: view

Pathways for PPP1CC Gene

genes like me logo Genes that share pathways with PPP1CC: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005977 glycogen metabolic process IEA --
GO:0006470 protein dephosphorylation ISS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with PPP1CC: view

Drugs for PPP1CC Gene

(4) Drugbank Compounds for PPP1CC Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
(2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID
46937013 Target experimental
9,10-Deepithio-9,10-Didehydroacanthifolicin
78111-17-8 46936318 Target experimental
Calyculin A
101932-71-2 46936510 Target experimental
Motuporin
  • nodularin-V
46937018 Target experimental

(5) Tocris Compounds for PPP1CC Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(8) HMDB Compounds for PPP1CC Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Fe2+
  • Armco iron
15438-31-0
Glycogen
  • Animal starch
9005-79-2
Manganese
  • Manganese
7439-96-5
Okadaic acid
  • 9,10-Deepithio-9,10-didehydroacanthifolicin
78111-17-8
genes like me logo Genes that share compounds with PPP1CC: view

Transcripts for PPP1CC Gene

Unigene Clusters for PPP1CC Gene

Protein phosphatase 1, catalytic subunit, gamma isozyme:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1CC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for PPP1CC Gene

GeneLoc Exon Structure for
PPP1CC
ECgene alternative splicing isoforms for
PPP1CC

Expression for PPP1CC Gene

mRNA expression in normal human tissues for PPP1CC Gene

Protein differential expression in normal tissues for PPP1CC Gene

This gene is overexpressed in Saliva (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1CC Gene

SOURCE GeneReport for Unigene cluster for PPP1CC Gene Hs.79081

genes like me logo Genes that share expressions with PPP1CC: view

Expression partners for PPP1CC Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1CC Gene

Orthologs for PPP1CC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1CC 35
  • 96.28 (n)
  • 99.69 (a)
PPP1CC 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1CC 35
  • 96.59 (n)
  • 98.76 (a)
PPP1CC 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5601 35
  • 91.72 (n)
  • 99.68 (a)
Ppp1cc 16
Ppp1cc 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1CC 35
  • 99.79 (n)
  • 100 (a)
PPP1CC 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1CC 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CC 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1CC 35
  • 87.72 (n)
  • 99.07 (a)
PPP1CC 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1CC 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1cc 35
  • 82.46 (n)
  • 99.38 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.3477 35
ppp1cc 35
  • 79.15 (n)
  • 97.83 (a)
ppp1cc 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta flw 37
  • 82 (a)
Pp1-13C 37
  • 92 (a)
Pp1-87B 37
  • 93 (a)
Pp1-Y2 37
  • 74 (a)
Pp1alpha-96A 37
  • 89 (a)
Pp1rY1 37
  • 58 (a)
PpD5 37
  • 62 (a)
PpD6 37
  • 60 (a)
PpN58A 37
  • 63 (a)
PpY-55A 37
  • 63 (a)
Pp1-87B 35
  • 72.24 (n)
  • 93.31 (a)
Pp1-13C 36
  • 91 (a)
ManyToMany
Pp1-87B 36
  • 92 (a)
ManyToMany
Pp1alpha-96A 36
  • 87 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011166 35
  • 69.88 (n)
  • 88.2 (a)
worm
(Caenorhabditis elegans)
Secernentea C06A1.3 37
  • 48 (a)
C09H5.7 37
  • 48 (a)
C23G10.1a 37
  • 45 (a)
C23G10.1b 37
  • 45 (a)
C24H11.1 37
  • 48 (a)
C24H11.2 37
  • 48 (a)
C25A6.1 37
  • 54 (a)
C27B7.6 37
  • 40 (a)
C30A5.4 37
  • 33 (a)
C34D4.2 37
  • 52 (a)
C47A4.3 37
  • 51 (a)
F22D6.9 37
  • 40 (a)
F23B12.1 37
  • 53 (a)
F25B3.4 37
  • 55 (a)
F42G8.8 37
  • 34 (a)
F49E11.7 37
  • 37 (a)
F52H3.6 37
  • 55 (a)
F58G1.3 37
  • 42 (a)
R08A2.2 37
  • 38 (a)
R13A5.11 37
  • 42 (a)
T03F1.5 37
  • 54 (a)
T25B9.2 37
  • 41 (a)
W03D8.2 37
  • 44 (a)
W09C3.6 37
  • 54 (a)
Y40H4A.2 37
  • 40 (a)
Y69E1A.4 37
  • 39 (a)
ZC477.2 37
  • 33 (a)
ZK354.9 37
  • 53 (a)
gsp-2 36
  • 88 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 36
  • 84 (a)
OneToMany
PPZ2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TOPP4 35
  • 68.45 (n)
  • 78.93 (a)
rice
(Oryza sativa)
Liliopsida Os03g0268000 35
  • 69.57 (n)
  • 82.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sds21 35
  • 67.23 (n)
  • 81.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7187 36
  • 91 (a)
OneToMany
Species with no ortholog for PPP1CC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1CC Gene

ENSEMBL:
Gene Tree for PPP1CC (if available)
TreeFam:
Gene Tree for PPP1CC (if available)

Paralogs for PPP1CC Gene

Paralogs for PPP1CC Gene

genes like me logo Genes that share paralogs with PPP1CC: view

Variants for PPP1CC Gene

Sequence variations from dbSNP and Humsavar for PPP1CC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2339525 -- 110,737,752(+) ACAGC(A/C)TAGGC intron-variant
rs3191028 -- 110,720,046(-) TGTCC(A/C)CCAGT utr-variant-3-prime, intron-variant
rs3191058 -- 110,721,822(-) TCCCC(A/C)CTTGA intron-variant
rs4402402 -- 110,737,513(+) AAAAG(A/G)AAAAA intron-variant
rs7138780 -- 110,716,630(+) attac(A/G)ggcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1CC Gene

Variant ID Type Subtype PubMed ID
esv2657045 CNV Deletion 23128226
esv2675965 CNV Deletion 23128226
nsv525818 CNV Loss 19592680

Relevant External Links for PPP1CC Gene

HapMap Linkage Disequilibrium report
PPP1CC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1CC Gene

Disorders for PPP1CC Gene

Relevant External Links for PPP1CC

Genetic Association Database (GAD)
PPP1CC
Human Genome Epidemiology (HuGE) Navigator
PPP1CC

No disorders were found for PPP1CC Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PPP1CC Gene

Publications for PPP1CC Gene

  1. Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. (PMID: 8394140) Barker H.M. … Cohen P.T.W. (Biochim. Biophys. Acta 1993) 3 4 23
  2. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PMID: 11564868) Connor J.H. … Shenolikar S. (Mol. Cell. Biol. 2001) 3 4
  3. Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. (PMID: 7500362) Egloff M.-P. … Barford D. (J. Mol. Biol. 1995) 3 4
  4. Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA. (PMID: 8111128) Norman S.A. … Mott D.M. (Mamm. Genome 1994) 3 4
  5. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. (PMID: 7556599) MacKintosh R.W. … MacKintosh C. (FEBS Lett. 1995) 3 4

Products for PPP1CC Gene

Sources for PPP1CC Gene

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