PPP1CC Gene
protein-coding GIFtS: 68
GCID: GC12M111157
|
|
protein phosphatase 1, catalytic subunit, gamma isozyme(Previous names: protein phosphatase 1, catalytic subunit, gamma isoform...)
| |
Aliases
for PPP1CC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme1 2 | | EC 3.1.3.163 8 | | PP1C1 2 | | PP1gamma1 | | Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform1 2 | | PPP1G2 | | Protein Phosphatase 1C Catalytic Subunit2 3 | | Serine/Threonine Phosphatase 1 Gamma2 | | PP-1G2 3 | | Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit2 |
Export aliases for PPP1CC gene to outside databasesPrevious GC identifers: GC12M116400 GC12M9F0150 GC12M109620 GC12M108174 |
Summaries
for PPP1CC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPP1CC:
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitousserine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed inmammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localizationpatterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymeswhich dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, andparticipates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. DephosphorylatesRPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role indephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinaseII. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cellcycle progression during the transition from mitosis into interphase
 summary
for PPP1CC: Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.
Gene Wiki entry for PPP1CC
|
Genomic Views
for PPP1CC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPP1CC gene promoter:
STAT5B E2F-5 Spz1 AP-4 GATA-2 FAC1 HSF2 c-Myb Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP1CC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1CC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.1-q24.2 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.1-q24.2PPP1CC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M111157: view genomic region
(about GC identifiers)
Start:
|
111,157,485 bp from pter |
End:
|
111,180,757 bp from pter |
Size:
|
23,273 bases |
Orientation:
|
minus strand |
|
Proteins
for PPP1CC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Size: 323 amino acids; 36984 Da
Cofactor: Binds 1 iron ion per subunit
Cofactor: Binds 1 manganese ion per subunit
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A,PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3Dand PPP1R3F (in brain) mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked.Interacts with PPP1R3B and PPP1R7. Isoform gamma-2 interacts with SPZ1 (By similarity). Component of the MLL5-Lcomplex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with CDCA2. PPP1R15Aand PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1;the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and preventsit from degradation. Interacts with PPP1R42; the interaction is direct (By similarity). Interacts with NOM1 andPPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB orPPP1CC. Interacts with PPP1R8. Interacts with isoform 1 and isoform 4 NEK2. Interacts with URI1; the interaction isphosphorylation-dependent and occurs in a growth factor-dependent manner
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome,centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (Bysimilarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic andcytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits.In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specificsites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochoresearly in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to lateanaphase. Also accumulates at the cleavage furrow and midbody by telophase
Miscellaneous: Microcystin toxin is bound to Cys-273 through a thioether bond
5 PDB 3D structures from  and Proteopedia  for PPP1CC:1IT6 (3D)
1JK7 (3D)
1U32 (3D)
2BCD (3D)
2BDX (3D)
Alternative splicing: 2 isoforms: P36873-1 P36873-2 Explore the universe of human proteins at neXtProt for PPP1CC: NX_P36873
Post-translational modifications:
Phosphorylated by NEK21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P36873
4/23 DME Specific Peptides for PPP1CC (P36873) (see all 23)
PPP1CC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001231903.1 NP_002701.1
ENSEMBL proteins: ENSP00000335084 ENSP00000341779 ENSP00000447528 ENSP00000447090 ENSP00000449986 ENSP00000447122 ENSP00000448981 ENSP00000448437 Reactome Protein details: P36873
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
PPP1CC for ontologies About GeneDecksing
PPP1CC Antibody Products:
Assay Products for PPP1CC: |
Protein
Domains /
Families
for PPP1CC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP1CC for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P36873ProtoNet protein and cluster: P36873 1 Blocks protein family: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily |
Function
for PPP1CC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PP1G_HUMAN, P36873Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymeswhich dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, andparticipates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. DephosphorylatesRPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role indephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinaseII. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cellcycle progression during the transition from mitosis into interphaseCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme regulation: Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress Genatlas biochemistry entry for PPP1CC:serine/threonine protein phosphatase 1,catalytic subunit,gamma,involved in cell division and glycogenmetabolism,expressed in skeletal muscle
Enzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPP1CC (NM_002710) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP1CC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CC |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
PPP1CC for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for PPP1CC:
Animal Models:
Mouse knock-out Ppp1cctm1Var for PPP1CC
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ppp1cc):
PPP1CC for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPP1CC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | M Phase | | | 3 | Resolution of Sister Chromatid Cohesion | | | 4 | Cell Cycle | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for PPP1CC (see all 6)
1 Tocris Bioscience Pathway for PPP1CC
5/6  GeneGo (Thomson Reuters) Pathways for PPP1CC (see all 6)
2  BioSystems Pathways for PPP1CC
5/18 
Reactome Pathways for PPP1CC (see all 18)
5/6 
Kegg Pathways (Kegg details for PPP1CC) (see all 6):
PPP1CC for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1CC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/570 Interacting proteins for PPP1CC (P368731, 2, 3 ENSP000003350844) via UniProtKB, MINT, STRING, and/or I2D (see all 570)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
PPP1CC for ontologies About GeneDecksing
|
Drugs & Compounds
for PPP1CC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for PPP1CC available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Cantharidin | Protein phosphatase 1 and 2A inhibitor | [56-25-7] | | Okadaic acid | Protein phosphatase 1 and 2A inhibitor | [78111-17-8] | | Calyculin A | Protein phosphatase 1 and 2A inhibitor | [101932-71-2] | | Tautomycetin | Selective PP1 inhibitor | [119757-73-2] |
6 HMDB Compounds for PPP1CC About this table
4 DrugBank Compounds for PPP1CC About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| 9,10-Deepithio-9,10-Didehydroacanthifolicin | -- | 78111-17-8 | target | -- | 17139284 17016423 10592235 | | Calyculin A | -- | 101932-71-2 | target | -- | 17139284 17016423 | | Motuporin | -- | -- | target | -- | 16343532 | | (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID | -- | -- | target | -- | -- |
Search CenterWatch for drugs/clinical trials and news about PPP1CC / PP1G
|
Transcripts
for PPP1CC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPP1CC gene (2 alternative transcripts): NM_001244974.1 NM_002710.3 Unigene Cluster for PPP1CC: Protein phosphatase 1, catalytic subunit, gamma isozyme Hs.79081 [show with all ESTs]Unigene Representative Sequence: NM_00271010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335007(uc021rdx.1 uc001tru.3) ENST00000340766 ENST00000550261
ENST00000546904 ENST00000551582 ENST00000553024 ENST00000546933 ENST00000550991
ENST00000551676 ENST00000551690
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPP1CC (NM_002710) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP1CC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CC |
Additional cDNA sequence: AK091841.1 AK297882.1 BC014073.2 L07395.1 X74008.1 21 DOTS entries: DT.100651097 DT.454897 DT.95208381 DT.95374891 DT.92459097 DT.95374897 DT.100651083 DT.100651087 DT.100873781 DT.92459110 DT.100873780 DT.100651100 DT.92459098 DT.121161474 DT.100865667 DT.121161652 DT.101975787 DT.121161471 DT.121161680 DT.95374887 DT.95374886 24/713 AceView cDNA sequences (see all 713): AA148901 CB151037 AI354380 AI299021 BQ959597 BQ421432 AU134461 AU125812 BM673636 CA312941 AU127789 AI474501 AI371830 BQ945993 CA416710 BE857343 BE270792 AW196934 AU124419 AA329576 CD364849 AU120795 AA977790 AI123380
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CC (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for PPP1CC
|
Expression
for PPP1CC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPP1CC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCTTCTT
About this image
See PPP1CC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP1CC
SOURCE GeneReport for Unigene cluster: Hs.79081
SABiosciences Expression via Pathway-Focused PCR Arrays including PPP1CC:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1CC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP1CC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1CC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1CC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CC |
Orthologs
for PPP1CC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPP1CC gene from 8/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPP1CC1 |
protein phosphatase 1, catalytic subunit, gamma isozyme |
87.72(n)
99.07(a) |
|
416872 NM_001006190.1 NP_001006190.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PPP1CA6 |
-- |
88(a) |
1 ↔ 1 |
1(93139455-93155737) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC054188.12 |
-- |
79.4(n) |
|
BC054188.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.34772 |
Danio rerio cDNA clone MGC55744 IMAGE3816387, complete more |
80(n) |
|
BC045444.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pp1-87B1 , 3 |
adult locomotory behavior protein
serine/threonine more3
Protein phosphatase 1 at 87B1 |
93(a)
(best of 10)3
72.24(n)1
93.31(a)1 |
|
492601 NM_080198.31 NP_524937.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F52H3.63 |
serine/threonine specific protein
phosphatase |
55(a)
(best of 28) |
|
II(10026560-10027773) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TOPP41 |
serine/threonine-protein phosphatase PP1 isozyme 4 |
68.45(n)
78.93(a) |
|
818571 NM_129543.2 NP_181514.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g02680001 |
hypothetical protein |
69.57(n)
82.61(a) |
|
4332369 NM_001056204.1 NP_001049669.1 |
ENSEMBL Gene Tree for PPP1CC (if available)
TreeFam Gene Tree for PPP1CC (if available) |
Paralogs
for PPP1CC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPP1CC gene
- PPP1CB2 PPP1CA2
11 SIMAP similar genes for PPP1CC using alignment to 8 protein entries: PP1G_HUMAN (see all proteins):PPP1CA PPP1CB PPP2CA PPP2CB PPP6C PPP4C
PPP3CB PPP3CA PPP5C PPP3CC PPEF1
PPP1CC for paralogs About GeneDecksing
|
Genomic Variants
for PPP1CC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for PPP1CC (111157485 - 111180757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP1CC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1CC |
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Disorders
/ Diseases
for PPP1CC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPP1CC for disorders About GeneDecksing
OMIM gene information: 176914
OMIM disorders: --
10  diseases for PPP1CC: About MalaCardsossifying fibroma male infertility lipoma infertility
epididymitis hypoxia immunodeficiency malaria
neuronitis ischemia
Human Genome Epidemiology (HuGE) Navigator: PPP1CC (1 document)
Export disorders for PPP1CC gene to outside databases
|
Publications
for PPP1CC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPP1CC gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with PPP1CC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. (PubMed id 8394140)1, 2, 9 Barker H.M.... Cohen P.T.W. (1993)
- Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H....Skalnik D.G. (2010)
- GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461)1, 2 Fujiki R.... Kato S. (2009)
- NOM1 targets protein phosphatase I to the nucleolus. (PubMed id 17965019)1, 2 Gunawardena S.R.... Conklin K.F. (2008)
- S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PubMed id 17936702)1, 2 Djouder N....Krek W. (2007)
- Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. (PubMed id 16343532)1, 7 Maynes J.T....James M.N. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PubMed id 12226088)1, 2 Ceulemans H....Bollen M. (2002)
- Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PubMed id 11564868)1, 2 Connor J.H.... Shenolikar S. (2001)
- Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. (PubMed id 11739654)1, 2 Trinkle-Mulcahy L....Lamond A.I. (2001)
|
External Searches for PPP1CC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPP1CC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPP1CC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPP1CC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PPP1CC gene:
Search GeneIP for patents involving PPP1CC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPP1CC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for PPP1CC | | OriGene shRNA RFP for PPP1CC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1CC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1CC | | | OriGene Protein Over-expression Lysate for PPP1CC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPP1CC | | OriGene 3'-UTR Clone for PPP1CC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PPP1CC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPP1CC | | OriGene Custom Protein Services for PPP1CC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP1CC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1CC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1CC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1CC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1CC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1CC |
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 | | | PPP1CC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CC |
|  |  |  | | | | ThermoFisher Antibody for PPP1CC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CC |
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