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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1CB Gene

protein-coding   GIFtS: 63
GCID: GC02P028974

Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme

(Previous names: protein phosphatase 1, catalytic subunit, beta isoform)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme1 2     Protein Phosphatase 1, Catalytic Subunit, Delta Isoform2
Protein Phosphatase 1, Catalytic Subunit, Beta Isoform1 2     Protein Phosphatase 1-Beta2
PP-1B2 3     Protein Phosphatase 1-Delta2
PPP1CD2 3     Serine/Threonine Protein Phosphatase PP1-Beta Catalytic Subunit2
EC 3.1.3.163 8     Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit2
PP1B2     EC 3.1.3.533
PP1beta2     

External Ids:    HGNC: 92821   Entrez Gene: 55002   Ensembl: ENSG000002136397   OMIM: 6005905   UniProtKB: P621403   

Export aliases for PPP1CB gene to outside databases

Previous GC identifers: GC02P028895 GC02P029067 GC02P028949 GC02P028886 GC02P028829 GC02P028716


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1CB Gene:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a
serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular
processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral
transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively
spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1CB Gene: 
PPP1CB (protein phosphatase 1, catalytic subunit, beta isozyme) is a protein-coding gene. Diseases associated with PPP1CB include cardiac conduction defect, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and VEGF and S-1P Signaling. GO annotations related to this gene include protein kinase binding and myosin-light-chain-phosphatase activity. An important paralog of this gene is PPP1CA.

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell
division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1
phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during
the transition from mitosis into interphase

summary for PPP1CB Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP1CB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1CB gene promoter:
         TBP   Pax-5   GATA-3   COMP1   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP1CB promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1CB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1CB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23

PPP1CB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1CB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P028974:  view genomic region     (about GC identifiers)

Start:
28,974,506 bp from pter      End:
29,025,806 bp from pter
Size:
51,301 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit  
Size: 327 amino acids; 37187 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by
inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory
subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and
PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and
PPP1R3F (in brain) mediate binding to glycogen. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By
similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC,
HCFC1, ACTB and OGT. Interacts with PPP1R7 and PPP1R12C. PPP1R15A and PPP1R15B mediate binding to EIF2S1.
Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82,
and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with TRIM28; the interaction is weak. Interacts
with PPP1R12A and NUAK1; the interaction is direct
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells
and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from
the nucleus to nuclear speckles
Secondary accessions: B2R5V4 D6W565 P37140 Q5U087 Q6FG45

Explore the universe of human proteins at neXtProt for PPP1CB: NX_P62140

Explore proteomics data for PPP1CB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62140

  • 4/23 DME Specific Peptides for PPP1CB (P62140) (see all 23)
     RPTDVPD  RPVTPPR  CGDIHGQ  TFGADVV 

    PPP1CB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP1CB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002700.1  NP_996759.1  

    ENSEMBL proteins: 
     ENSP00000390715   ENSP00000398839   ENSP00000414918   ENSP00000394589   ENSP00000296122  
     ENSP00000378769   ENSP00000388056   ENSP00000351298  
    Reactome Protein details: P62140
    Human Recombinant Protein Products for PPP1CB: 
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    Novus Biologicals PPP1CB Protein
    Novus Biologicals PPP1CB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000164protein phosphatase type 1 complex IEA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm ----
    GO:0042587glycogen granule IEA--

    PPP1CB for ontologies           About GeneDecksing



    PPP1CB Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 Metallo_PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P62140

    ProtoNet protein and cluster: P62140

    UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    PPP1CB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP1B_HUMAN, P62140
    Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
    holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell
    division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
    Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1
    phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during
    the transition from mitosis into interphase
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Catalytic activity: [Myosin light-chain] phosphate + H(2)O = [myosin light-chain] + phosphate
    Enzyme regulation: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The
    phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug
    that protects cells from endoplasmic reticulum stress

         Genatlas biochemistry entry for PPP1CB:
    serine/threonine protein phosphatase 1,catalytic subunit,beta

         Enzyme Numbers (IUBMB): EC 3.1.3.161 2 EC 3.1.3.531

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity ----
    GO:0005515protein binding IPI17511879
    GO:0016787hydrolase activity ----
    GO:0017018myosin phosphatase activity ISS--
         
    PPP1CB for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PPP1CB:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased cell number in G2M,   Nuclear pre-40S maturation def 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ppp1cb):
     mortality/aging 

    PPP1CB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP1CB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP1CB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1CB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1CB 

    miRNA
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    8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1CB (see all 142):
    hsa-miR-411* hsa-miR-4275 hsa-miR-1243 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-99b hsa-miR-130a* hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidPPP1CB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP1CB About   (see all 38)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF20.47
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Insulin signaling pathway0.31
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    3Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    4TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.90
    TGF-beta receptor signaling activates SMADs0.90
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/12 EMD Millipore Pathways for PPP1CB (see all 12)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Signal transduction Calcium signaling
    Translation Insulin regulation of translation
    Transcription CREB pathway

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1CB (see all 9)
        Actin-Based Motility by Rho Family GTPases
    G-AlphaI Signaling
    Activation of PKC through GPCR
    Transendothelial Migration of Leukocytes
    Cellular Effects of Sildenafil

    1 Tocris Bioscience Pathway for PPP1CB
        Insulin Pathway

    5/13 GeneGo (Thomson Reuters) Pathways for PPP1CB (see all 13)
        Translation Regulation of EIF2 activity
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Translation Insulin regulation of translation

    2 BioSystems Pathways for PPP1CB
        G13 Signaling Pathway
    PLK1 signaling events

    5/13        Reactome Pathways for PPP1CB (see all 13)
        TGF-beta receptor signaling activates SMADs
    Metabolism
    Cell Cycle
    Regulation of PLK1 Activity at G2/M Transition
    Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis


    5/13         Kegg Pathways  (Kegg details for PPP1CB) (see all 13):
        mRNA surveillance pathway
    Oocyte meiosis
    Vascular smooth muscle contraction
    Hippo signaling pathway
    Focal adhesion


    PPP1CB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1CB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/180 Interacting proteins for PPP1CB (P621401, 2, 3 ENSP000002961224) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383981, 3, ENSP000003502834EBI-352350,EBI-349905 I2D: score=2 STRING: ENSP00000350283
    ZFYVE9O954052, 3MINT-62034 I2D: score=3 
    IKBKGQ9Y6K92, 3MINT-48226 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49148 I2D: score=2 
    ENSG00000227720O609273, ENSP000004122974I2D: score=2 STRING: ENSP00000412297
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0005977glycogen metabolic process IEA--
    GO:0005979regulation of glycogen biosynthetic process IEA--
    GO:0005981regulation of glycogen catabolic process IEA--

    PPP1CB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP1CB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PPP1CB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    6 HMDB Compounds for PPP1CB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    GlycogenAnimal starch (see all 5)9005-79-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PPP1CB / PP1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PPP1CB gene (3 alternative transcripts): 
    NM_002709.2  NM_206876.1  NM_206877.1  

    Unigene Cluster for PPP1CB:

    Protein phosphatase 1, catalytic subunit, beta isozyme
    Hs.702907  [show with all ESTs]
    Unigene Representative Sequence: NM_002709
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455580(uc010ymk.2) ENST00000420282 ENST00000441461 ENST00000427786
    ENST00000296122 ENST00000395366(uc002rmh.3) ENST00000464273 ENST00000418910
    ENST00000358506(uc010ymj.2 uc002rmg.3 uc010yml.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1CB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1CB

    Additional mRNA sequence: 

    AF092905.1 AK295957.1 AK303682.1 AK312329.1 AK316532.1 BC002697.2 BC012045.1 BT019744.1 
    BX647295.1 BX647970.1 CR542263.1 CR542285.1 X80910.1 

    24/34 DOTS entries (see all 34):

    DT.95313140  DT.95168383  DT.92461582  DT.100884524  DT.92027560  DT.95231848  DT.120950929  DT.95168374 
    DT.120950823  DT.95168389  DT.99975231  DT.40109550  DT.87079316  DT.99981906  DT.97788988  DT.97855023 
    DT.100884514  DT.100884515  DT.120950819  DT.120950900  DT.120950905  DT.95168386  DT.100884522  DT.101973029 

    24/727 AceView cDNA sequences (see all 727):

    AW469789 AA989083 AL579213 AA251855 AI002043 AA748846 AA312874 AU121256 
    N95078 BX647295 AA251856 BU147113 CB122331 NM_206876 N79870 AI354315 
    BE465383 AA742317 AW519096 R26915 BF939082 BQ220300 BM984437 AA825575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1CB expression in normal human tissues (normalized intensities)      PPP1CB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTGCTG
    PPP1CB Expression
    About this image


    PPP1CB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Bone marrow-derived hematopoietic stem cells
             bone marrow cd34+   
     
     Limb (Muscoskeletal System)
             Zone Of Polarizing Activity Cells Limb Bud
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See PPP1CB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1CB

    SOURCE GeneReport for Unigene cluster: Hs.702907
        SABiosciences Expression via Pathway-Focused PCR Array including PPP1CB: 
              Protein Phosphatases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP1CB gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1cb1 , 5 protein phosphatase 1, catalytic subunit, beta isoform1, 5 94.6(n)1
    100(a)1
      5 (17.33 cM)5
    190461  NM_172707.31  NP_766295.21 
     324589745 
    chicken
    (Gallus gallus)
    Aves PPP1CB1 protein phosphatase 1, catalytic subunit, beta isozyme 87.56(n)
    100(a)
      396019  NM_205122.1  NP_990453.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1CB6
    protein phosphatase 1, catalytic subunit, beta iso...
    100(a)
    1 ↔ 1
    1(248252909-248285191)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU909047.12   -- 82.27(n)    BU909047.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA474593.12   -- 80.53(n)   368904  CA474593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta flw1 , 3 protein amino acid dephosphorylation
    protein serine/threonine more3
    flapwing1
    90(a)
    (best of 10)3
    71.44(n)1
    90.65(a)1
      442891  NM_079999.21  NP_524738.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C25A6.13
    gsp-11
    Protein GSP-11 56(a)
    (best of 27)3
    75.64(n)1
    93.27(a)1
      V(5408340-5409883)3
    1794861  NM_073332.31  NP_505733.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLC76
    Type 1 serine/threonine protein phosphatase cataly...
    81(a)
    1 → many
    V(432495-433958)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOPP31 serine/threonine-protein phosphatase PP1 isozyme 3 68.81(n)
    74.92(a)
      842708  NM_105077.3  NP_176587.1 
    rice
    (Oryza sativa)
    Liliopsida Os.121642 Oryza sativa protein phosphatase 1 mRNA, complete cds 75.51(n)    AK073140.1 


    ENSEMBL Gene Tree for PPP1CB (if available)
    TreeFam Gene Tree for PPP1CB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1CB gene
    PPP1CA2  PPP1CC2  
    11 SIMAP similar genes for PPP1CB using alignment to 6 protein entries:     PP1B_HUMAN (see all proteins):
    PPP1CC    PPP1CA    PPP2CB    PPP2CA    PPP3CA    PPP3CB
    PPP6C    PPP3CC    PPEF1    PPP4C    PPP5C

    PPP1CB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1128 SNPs in PPP1CB are shown (see all 1128)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167018881,2
    F--28972634(+) GGGCCC/TCATGA 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1452324841,2
    --28972816(+) ATCTTC/TTTCTT 2 -- us2k10--------
    rs111271881,2
    C,F,A,H--28972852(+) TGTGTA/GGCCTA 2 -- us2k115Minor allele frequency- G:0.42NS EA NA WA CSA 790
    rs1491390431,2
    --28972937(+) CTCACA/GGTTTT 2 -- us2k10--------
    rs1449439301,2
    --28972982(+) TTTACA/CCTGAT 2 -- us2k10--------
    rs1832862181,2
    C--28973002(+) TATGTA/GAACTA 2 -- us2k10--------
    rs1120524991,2
    C,F--28973035(+) TAAAGT/CAGGGT 2 -- us2k12Minor allele frequency- C:0.02NA 122
    rs1381610811,2
    C--28973069(+) AAAGAA/GTGATG 2 -- us2k10--------
    rs1876322031,2
    --28973148(+) CTGCCC/TGTTCA 2 -- us2k10--------
    rs2003809551,2
    C--28973187(+) ACTACC/TCCAGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP1CB (28974506 - 29025806 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PPP1CB: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1CB
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1CB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600590    OMIM disorders: --

    10 diseases for PPP1CB:    About MalaCards
    cardiac conduction defect    intrahepatic cholangiocarcinoma    cholangiocarcinoma    retinoblastoma
    insulin resistance    melanoma    gastric cancer    endotheliitis
    breast cancer    neuronitis


    PPP1CB for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PPP1CB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11056045 (1)

    Genetic Association Database (GAD): PPP1CB
    Human Genome Epidemiology (HuGE) Navigator: PPP1CB (1 document)

    Export disorders for PPP1CB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1CB gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with PPP1CB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). (PubMed id 8312365)1, 2, 3 Barker H.M.... Cohen P.T.W. (1994)
    2. Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. (PubMed id 7796987)1, 2, 9 Prochazka M.... Bogardus C. (1995)
    3. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PubMed id 11399775)1, 2, 9 Tan I.... Leung T. (2001)
    4. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PubMed id 20424263)1, 2 Li X....Ann D.K. (2010)
    5. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H....Skalnik D.G. (2010)
    6. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461)1, 2 Fujiki R.... Kato S. (2009)
    7. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    8. TIMAP is a positive regulator of pulmonary endothelial barrier function. (PubMed id 18586956)1, 2 Csortos C....Verin A.D. (2008)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5500 HGNC: 9282 AceView: PPP1CBandSPDY1 Ensembl:ENSG00000213639 euGenes: HUgn5500
    ECgene: PPP1CB Kegg: 5500 H-InvDB: PPP1CB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1CB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1CB Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt032.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1CB gene:
    Search GeneIP for patents involving PPP1CB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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