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Aliases for PPP1CB Gene

Aliases for PPP1CB Gene

  • Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Beta Isoform 2 3
  • EC 3.1.3.16 4 64
  • PPP1CD 3 4
  • PP-1B 3 4
  • Serine/Threonine Protein Phosphatase PP1-Beta Catalytic Subunit 3
  • Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit 3
  • Protein Phosphatase 1, Catalytic Subunit, Delta Isoform 3
  • Epididymis Secretory Sperm Binding Protein Li 80p 3
  • Protein Phosphatase 1-Delta 3
  • Protein Phosphatase 1-Beta 3
  • EC 3.1.3.53 4
  • HEL-S-80p 3
  • PP1beta 3
  • PP1B 3

External Ids for PPP1CB Gene

Summaries for PPP1CB Gene

Entrez Gene Summary for PPP1CB Gene

  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1CB Gene

PPP1CB (Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme) is a Protein Coding gene. Diseases associated with PPP1CB include hiv-1 and cardiac conduction defect. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include protein kinase binding and myosin-light-chain-phosphatase activity. An important paralog of this gene is PPP1CC.

UniProtKB/Swiss-Prot for PPP1CB Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CB Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP1CB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1CB Gene

Genomics for PPP1CB Gene

Genomic Location for PPP1CB Gene

Start:
28,751,640 bp from pter
End:
28,802,940 bp from pter
Size:
51,301 bases
Orientation:
Plus strand

Genomic View for PPP1CB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CB Gene

Regulatory Elements for PPP1CB Gene

Proteins for PPP1CB Gene

  • Protein details for PPP1CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62140-PP1B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-beta catalytic subunit
    Protein Accession:
    P62140
    Secondary Accessions:
    • B2R5V4
    • D6W565
    • P37140
    • Q5U087
    • Q6FG45

    Protein attributes for PPP1CB Gene

    Size:
    327 amino acids
    Molecular mass:
    37187 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7 and PPP1R12C. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with TRIM28; the interaction is weak. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with FOXP3.

neXtProt entry for PPP1CB Gene

Proteomics data for PPP1CB Gene at MOPED

Post-translational modifications for PPP1CB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys25, Lys97, Lys112, Lys140, Lys146, Lys149, Lys167, Lys259, and Lys303

Other Protein References for PPP1CB Gene

Domains for PPP1CB Gene

Gene Families for PPP1CB Gene

HGNC:
  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

Protein Domains for PPP1CB Gene

UniProtKB/Swiss-Prot:

PP1B_HUMAN
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.:
    • P62140
genes like me logo Genes that share domains with PPP1CB: view

Function for PPP1CB Gene

Molecular function for PPP1CB Gene

GENATLAS Biochemistry: serine/threonine protein phosphatase 1,catalytic subunit,beta
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: [Myosin light-chain] phosphate + H(2)O = [myosin light-chain] + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
UniProtKB/Swiss-Prot Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot Induction: Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Enzyme Numbers (IUBMB) for PPP1CB Gene

Gene Ontology (GO) - Molecular Function for PPP1CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity --
GO:0005515 protein binding IPI 17511879
GO:0016787 hydrolase activity --
GO:0016791 phosphatase activity ISS --
genes like me logo Genes that share ontologies with PPP1CB: view
genes like me logo Genes that share phenotypes with PPP1CB: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1CB Gene

Localization for PPP1CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CB Gene

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1CB Gene COMPARTMENTS Subcellular localization image for PPP1CB gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with PPP1CB: view

Pathways for PPP1CB Gene

genes like me logo Genes that share pathways with PPP1CB: view

Gene Ontology (GO) - Biological Process for PPP1CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0005977 glycogen metabolic process IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0005981 regulation of glycogen catabolic process IEA --
genes like me logo Genes that share ontologies with PPP1CB: view

Compounds for PPP1CB Gene

(5) Tocris Compounds for PPP1CB Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(6) HMDB Compounds for PPP1CB Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Glycogen
  • Animal starch
9005-79-2
Iron
  • Armco iron
7439-89-6
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
genes like me logo Genes that share compounds with PPP1CB: view

Transcripts for PPP1CB Gene

Unigene Clusters for PPP1CB Gene

Protein phosphatase 1, catalytic subunit, beta isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CB Gene

No ASD Table

Relevant External Links for PPP1CB Gene

GeneLoc Exon Structure for
PPP1CB
ECgene alternative splicing isoforms for
PPP1CB

Expression for PPP1CB Gene

mRNA expression in normal human tissues for PPP1CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1CB Gene

SOURCE GeneReport for Unigene cluster for PPP1CB Gene Hs.702907

genes like me logo Genes that share expressions with PPP1CB: view

Orthologs for PPP1CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1CB 36
  • 99.69 (n)
  • 100 (a)
PPP1CB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1CB 36
  • 95.82 (n)
  • 100 (a)
PPP1CB 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1CB 36
  • 96.64 (n)
  • 99.08 (a)
PPP1CB 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1cb 36
  • 94.6 (n)
  • 100 (a)
Ppp1cb 16
Ppp1cb 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1CB 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CB 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1cb 36
  • 93.88 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PPP1CB 36
  • 87.56 (n)
  • 100 (a)
PPP1CB 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1CB 37
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1cb 36
  • 82.16 (n)
  • 99.69 (a)
Str.106 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ppp1cb 36
  • 79.41 (n)
  • 97.25 (a)
ppp1cbl 37
  • 100 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003114 36
  • 69.83 (n)
  • 87.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta flw 36
  • 71.44 (n)
  • 90.65 (a)
flw 37
  • 64 (a)
OneToOne
Pp1alpha-96A 38
  • 85 (a)
PpD5 38
  • 61 (a)
PpN58A 38
  • 62 (a)
PpY-55A 38
  • 63 (a)
PpD6 38
  • 59 (a)
Pp1-87B 38
  • 88 (a)
Pp1-Y2 38
  • 74 (a)
Pp1rY1 38
  • 58 (a)
flw 38
  • 90 (a)
Pp1-13C 38
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea gsp-1 36
  • 75.27 (n)
  • 92.68 (a)
gsp-1 37
  • 89 (a)
OneToOne
F52H3.6 38
  • 55 (a)
F42G8.8 38
  • 36 (a)
C23G10.1a 38
  • 48 (a)
F49E11.7 38
  • 40 (a)
T03F1.5 38
  • 54 (a)
C34D4.2 38
  • 52 (a)
F58G1.3 38
  • 43 (a)
R08A2.2 38
  • 38 (a)
C24H11.2 38
  • 48 (a)
W09C3.6 38
  • 54 (a)
Y69E1A.4 38
  • 37 (a)
C47A4.3 38
  • 52 (a)
C06A1.3 38
  • 47 (a)
C23G10.1b 38
  • 48 (a)
C27B7.6 38
  • 38 (a)
Y40H4A.2 38
  • 38 (a)
F25B3.4 38
  • 55 (a)
C25A6.1 38
  • 56 (a)
W03D8.2 38
  • 47 (a)
F22D6.9 38
  • 41 (a)
C09H5.7 38
  • 48 (a)
C30A5.4 38
  • 33 (a)
F23B12.1 38
  • 52 (a)
R13A5.11 38
  • 43 (a)
ZK354.9 38
  • 54 (a)
T25B9.2 38
  • 40 (a)
C24H11.1 38
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 37
  • 81 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10387 36
thale cress
(Arabidopsis thaliana)
eudicotyledons TOPP3 36
  • 68.8 (n)
  • 74.44 (a)
rice
(Oryza sativa)
Liliopsida Os.12164 36
Os06g0164100 36
  • 68.28 (n)
  • 78.06 (a)
Species with no ortholog for PPP1CB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1CB Gene

ENSEMBL:
Gene Tree for PPP1CB (if available)
TreeFam:
Gene Tree for PPP1CB (if available)

Paralogs for PPP1CB Gene

Paralogs for PPP1CB Gene

Selected SIMAP similar genes for PPP1CB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP1CB: view

Variants for PPP1CB Gene

Sequence variations from dbSNP and Humsavar for PPP1CB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3190 -- 28,802,613(-) ACTTA(C/T)ATGGA utr-variant-3-prime
rs7475 -- 28,800,883(+) TTATG(A/G)ATTGG utr-variant-3-prime
rs13644 -- 28,801,870(+) ATCCT(A/T)TGCAT utr-variant-3-prime
rs15462 -- 28,800,326(+) GTCTC(C/T)TTTTC utr-variant-3-prime
rs966250 -- 28,751,273(+) ATTTT(G/T)TAGAA upstream-variant-2KB

Relevant External Links for PPP1CB Gene

HapMap Linkage Disequilibrium report
PPP1CB
Human Gene Mutation Database (HGMD)
PPP1CB

No data available for Structural Variations from Database of Genomic Variants (DGV) for PPP1CB Gene

Disorders for PPP1CB Gene

(1) Novoseek inferred disease relationships for PPP1CB Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for PPP1CB

Genetic Association Database (GAD)
PPP1CB
Human Genome Epidemiology (HuGE) Navigator
PPP1CB
genes like me logo Genes that share disorders with PPP1CB: view

No data available for UniProtKB/Swiss-Prot for PPP1CB Gene

Publications for PPP1CB Gene

  1. Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. (PMID: 7796987) Prochazka M. … Bogardus C. (Diabetologia 1995) 3 4 23
  2. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I. … Leung T. (J. Biol. Chem. 2001) 3 4 23
  3. Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). (PMID: 8312365) Barker H.M. … Cohen P.T.W. (Biochim. Biophys. Acta 1994) 2 3 4
  4. Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells. (PMID: 12185196) Morimoto H. … Haneji T. (J. Histochem. Cytochem. 2002) 3 23
  5. Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. (PMID: 7857673) Saadat M. … Yoshida M.C. (Jpn. J. Genet. 1994) 3 23

Products for PPP1CB Gene

Sources for PPP1CB Gene

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