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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPP1CB Gene

protein-coding GIFtS: 63
GCID: GC02P028974

protein phosphatase 1, catalytic subunit, beta isozyme

(Previous names: protein phosphatase 1, catalytic subunit, beta isoform...)

Explore 10 diseases affiliated with
PPP1CB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme¹ ²		Protein Phosphatase 1, Catalytic Subunit, Delta Isoform²
PP-1B¹ ² ³		Protein Phosphatase 1-Beta²
PP1B¹ ²		Protein Phosphatase 1-Delta²
PP1beta¹ ²		Serine/Threonine Protein Phosphatase PP1-Beta Catalytic Subunit²
Protein Phosphatase 1, Catalytic Subunit, Beta Isoform¹ ²		Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit²
PPP1CD² ³		EC 3.1.3.53³
EC 3.1.3.16³ ⁸

External Ids:	HGNC: 9282¹	Entrez Gene: 5500²	Ensembl: ENSG00000213639⁷	OMIM: 600590⁵	UniProtKB: P62140³

Export aliases for PPP1CB gene to outside databases

Previous GC identifers: GC02P028895 GC02P029067 GC02P028949 GC02P028886 GC02P028829 GC02P028716

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1CB:

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a

serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular

processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral

transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively

spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140

Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes

which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it

participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in

regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex,

which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis

into interphase

summary for PPP1CB:

Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from

serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the

actions of kinases and phosphorylases and therefore play an integral role in many signal transduction

pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,

calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a

divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the

phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This

makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr

phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are

subtype-specific.

Gene Wiki entry for PPP1CB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPP1CB gene promoter:
TBP Pax-5 GATA-3 COMP1 HNF-3beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP1CB promoter sequence

Search SABiosciences Chromatin IP Primers for PPP1CB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1CB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23

PPP1CB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1CB gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P028974: view genomic region (about GC identifiers)

Start:	28,974,506 bp from pter	End:	29,025,806 bp from pter
Size:	51,301 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Size: 327 amino acids; 37187 Da

Cofactor: Binds 1 iron ion per subunit (By similarity)

Cofactor: Binds 1 manganese ion per subunit (By similarity)

Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor

2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The

targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate

binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate

binding to glycogen. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Component of the MLL5-L

complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7 and

PPP1R12C. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with PPP1R16B. Component of the PTW/PP1

phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8.

Interacts with TRIM28; the interaction is weak. Interacts with PPP1R12A and NUAK1; the interaction is direct

Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can

be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to

nuclear speckles

Secondary accessions: B2R5V4 D6W565 P37140 Q5U087 Q6FG45

Explore the universe of human proteins at neXtProt for PPP1CB: NX_P62140

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62140

4/23 DME Specific Peptides for PPP1CB (P62140) (see all 23)

RPTDVPD

RPVTPPR

CGDIHGQ

TFGADVV

PPP1CB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002700.1 NP_996759.1

ENSEMBL proteins:

ENSP00000390715 ENSP00000398839 ENSP00000414918 ENSP00000394589 ENSP00000296122

ENSP00000378769 ENSP00000388056 ENSP00000351298

Reactome Protein details: P62140
Human Recombinant Protein Products:

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	OriGene Purified Protein: PPP1CB OriGene Protein Over-expression Lysate (see all 2): PPP1CB OriGene Custom Protein Services for PPP1CB
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	Novus Biologicals PPP1CB Protein Novus Biologicals PPP1CB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000164	protein phosphatase type 1 complex	IEA	--
GO:0005730	nucleolus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0042587	glycogen granule	IEA	--
GO:0070688	MLL5-L complex	IDA	19377461

PPP1CB for ontologies About GeneDecksing

PPP1CB Antibody Products:

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	Abcam antibodies for PPP1CB
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for PPP1CB

Assay Products for PPP1CB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PPP1CB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPP1CB for domains About GeneDecksing

2 InterPro domains/families:

IPR004843 Metallo_PEstase_dom

IPR006186 Ser/Thr-sp_prot-phosphatase

Graphical View of Domain Structure for InterPro Entry P62140

ProtoNet protein and cluster: P62140

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140

Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes

which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it

participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in

regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex,

which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis

into interphase

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Catalytic activity: [Myosin light-chain] phosphate + H(2)O = [myosin light-chain] + phosphate

Enzyme regulation: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The

phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that

protects cells from endoplasmic reticulum stress

Genatlas biochemistry entry for PPP1CB:

serine/threonine protein phosphatase 1,catalytic subunit,beta

Enzyme Numbers (IUBMB): EC 3.1.3.16¹ ² EC 3.1.3.53¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PPP1CB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1CB
		8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1CB (see all 142):
		hsa-miR-411* hsa-miR-4275 hsa-miR-1243 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-99b hsa-miR-130a* hsa-miR-23c

		SwitchGear 3'UTR luciferase reporter plasmid: PPP1CB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1CB (see all 7) OriGene shRNA RFP: PPP1CB OriGene siRNA: PPP1CB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1CB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PPP1CB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PPP1CB (NM_002709)
		Browse Sino Biological Human cDNA Clones
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPP1CB
		Search LifeMap BioReagents cell lines for PPP1CB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CB

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004721	phosphoprotein phosphatase activity	--	--
GO:0004722	protein serine/threonine phosphatase activity	--	--
GO:0005515	protein binding	IPI	17511879
GO:0016787	hydrolase activity	--	--
GO:0017018	myosin phosphatase activity	ISS	--

PPP1CB for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for PPP1CB:

Decreased Salmonella enterica	Decreased focal adhesion (FA)	Downregulation of NF-kappaB pa	Downregulation of NF-kappaB pa
Increased cell number in G2M,	Nuclear pre-40S maturation def

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ppp1cb):

mortality/aging

PPP1CB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

Translation_Insulin regulation of translation	0.35	Translation _Regulation of EIF2 activity	0.25
Regulation of lipid metabolism_Insulin signaling-generic cascades	0.35	Translation Regulation activity of EIF2	0.25
Regulation of lipid metabolism Insulin signaling:generic cascades	0.35	Insulin signaling pathway	0.17
Translation Insulin regulation of translation	0.35

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

Signal transduction_Activation of PKC via G-Protein coupled receptor

Signal transduction_Activation of PKC via G-Protein coupled receptor

1.00

Signal transduction Activation of PKC via G-Protein coupled receptor

0.98

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 EMD Millipore Pathways for PPP1CB (see all 12)

	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Signal transduction Calcium signaling
	Translation Insulin regulation of translation
	Transcription CREB pathway

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1CB (see all 9)

	Actin-Based Motility by Rho Family GTPases
	G-AlphaI Signaling
	Activation of PKC through GPCR
	Transendothelial Migration of Leukocytes
	Cellular Effects of Sildenafil

1 Tocris Bioscience Pathway for PPP1CB

Insulin Pathway

5/13 GeneGo (Thomson Reuters) Pathways for PPP1CB (see all 13)

	Translation Regulation of EIF2 activity
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Signal transduction Activation of PKC via G-Protein coupled receptor
	Translation Insulin regulation of translation

2 BioSystems Pathways for PPP1CB

	G13 Signaling Pathway
	PLK1 signaling events

5/13 Reactome Pathways for PPP1CB (see all 13)

	TGF-beta receptor signaling activates SMADs
	Metabolism
	Cell Cycle
	Regulation of PLK1 Activity at G2/M Transition
	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

5/6 Kegg Pathways (Kegg details for PPP1CB) (see all 6):

	Oocyte meiosis
	Vascular smooth muscle contraction
	Focal adhesion
	Long-term potentiation
	Regulation of actin cytoskeleton

PPP1CB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPP1CB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/163 Interacting proteins for PPP1CB (P62140^{1, 2, 3} ENSP00000296122⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 163)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BRCA1	P38398¹^,³, ENSP00000350283⁴	EBI-352350,EBI-349905 I2D: score=2 STRING: ENSP00000350283
ZFYVE9	O95405²^,³	MINT-62034 I2D: score=3
IKBKG	Q9Y6K9²^,³	MINT-48226 I2D: score=2
RIPK3	Q9Y572²^,³	MINT-49148 I2D: score=2
AKT1	P31749²^,³, ENSP00000270202⁴	MINT-8291798 MINT-8291822 I2D: score=1 STRING: ENSP00000270202

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005977	glycogen metabolic process	IEA	--
GO:0005979	regulation of glycogen biosynthetic process	IEA	--
GO:0005981	regulation of glycogen catabolic process	IEA	--
GO:0006470	protein dephosphorylation	IEA	--
GO:0006629	lipid metabolic process	TAS	--

PPP1CB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PPP1CB:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PPP1CB available from Tocris Bioscience About this table

Compound	Action	CAS #
Cantharidin	Protein phosphatase 1 and 2A inhibitor	[56-25-7]
Okadaic acid	Protein phosphatase 1 and 2A inhibitor	[78111-17-8]
Calyculin A	Protein phosphatase 1 and 2A inhibitor	[101932-71-2]
Tautomycetin	Selective PP1 inhibitor	[119757-73-2]

6 HMDB Compounds for PPP1CB About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Glycogen	Animal starch (see all 5)	9005-79-2	--
Iron	Armco iron (see all 19)	7439-89-6	--
Manganese	manganese	7439-96-5	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about PPP1CB / PP1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPP1CB gene (3 alternative transcripts):

NM_002709.2 NM_206876.1 NM_206877.1

Unigene Cluster for PPP1CB:

Protein phosphatase 1, catalytic subunit, beta isozyme

Hs.702907 [show with all ESTs]

Unigene Representative Sequence: NM_002709

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455580(uc010ymk.2) ENST00000420282 ENST00000441461 ENST00000427786

ENST00000296122 ENST00000395366(uc002rmh.3) ENST00000464273 ENST00000418910

ENST00000358506(uc010ymj.2 uc002rmg.3 uc010yml.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PPP1CB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1CB
		8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1CB (see all 142):
		hsa-miR-411* hsa-miR-4275 hsa-miR-1243 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-99b hsa-miR-130a* hsa-miR-23c

		SwitchGear 3'UTR luciferase reporter plasmid: PPP1CB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1CB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1CB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1CB

Additional cDNA sequence:

AF092905.1 AK295957.1 AK303682.1 AK312329.1 AK316532.1 BC002697.2 BC012045.1 BT019744.1

BX647295.1 BX647970.1 CR542263.1 CR542285.1 X80910.1

24/28 DOTS entries (see all 28):

DT.95313140 DT.100884524 DT.95168383 DT.92461582 DT.95231848 DT.92027560 DT.120950929 DT.95168374

DT.120950823 DT.95168389 DT.99975231 DT.40109550 DT.87079316 DT.97788988 DT.97855023 DT.100884514

DT.120950819 DT.120950900 DT.100884522 DT.101973029 DT.120950784 DT.120950785 DT.120950887 DT.120950939

24/727 AceView cDNA sequences (see all 727):

AA742231 BM984437 AA251855 BM701727 F06377 BQ946172 AI627415 BP375282

BM927041 AA788610 F09332 BX342144 AI824059 BU685844 T28839 BX476307

AI420785 BM932305 AL558894 BG428911 R26915 AA989083 BM717982 CR592930

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP1CB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGATTGCTG

About this image

PPP1CB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Zone Of Polarizing Activity Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PPP1CB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP1CB

SOURCE GeneReport for Unigene cluster: Hs.702907

SABiosciences Expression via Pathway-Focused PCR Array including PPP1CB:

Protein Phosphatases in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CB gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPP1CB¹	protein phosphatase 1, catalytic subunit, beta isozyme	87.56(n) 100(a)		396019 NM_205122.1 NP_990453.1
lizard (Anolis carolinensis)	Reptilia	PPP1CB⁶	--	92(a)	1 ↔ 1	1(248274784-248282469)
African clawed frog (Xenopus laevis)	Amphibia	BU909047.1²	--	82.27(n)		BU909047.1
zebrafish (Danio rerio)	Actinopterygii	CA474593.1²	--	80.53(n)		368904 CA474593.1
fruit fly (Drosophila melanogaster)	Insecta	flw^{1 , 3}	protein amino acid dephosphorylation protein serine/threonine more³ flapwing¹	90(a) (best of 10)³ 71.44(n)¹ 90.65(a)¹		44289¹ NM_079999.2¹ NP_524738.1¹
worm (Caenorhabditis elegans)	Secernentea	C25A6.1³ gsp-1¹	Protein GSP-1¹	56(a) (best of 27)³ 75.64(n)¹ 93.27(a)¹		V(5408340-5409883)³ 179486¹ NM_073332.3¹ NP_505733.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	TOPP3¹	serine/threonine-protein phosphatase PP1 isozyme 3	68.81(n) 74.92(a)		842708 NM_105077.3 NP_176587.1
rice (Oryza sativa)	Liliopsida	Os.12164²	Oryza sativa protein phosphatase 1 mRNA, complete cds	75.51(n)		AK073140.1

ENSEMBL Gene Tree for PPP1CB (if available)
TreeFam Gene Tree for PPP1CB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPP1CB gene

PPP1CA² PPP1CC²

11 SIMAP similar genes for PPP1CB using alignment to 6 protein entries: PP1B_HUMAN (see all proteins):

PPP1CA PPP1CC PPP2CB PPP2CA PPP3CA PPP3CB

PPP6C PPP3CC PPEF1 PPP4C PPP5C

PPP1CB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57569499^1,2	C,	--	28761020(+)	`CTGTA-/AGCCTT`	1	--	int¹		1		NA	2
rs116701888^1,2	F,	--	28972634(+)	`GGGCCC/TCATGA`	2	--	us2k¹		1		WA	118
rs145232484^1,2		--	28972816(+)	`ATCTTC/TTTCTT`	2	--	us2k¹		0	--	--	--	--
rs11127188^1,2	C,F,A,H,	--	28972852(+)	`TGTGTA/GGCCTA`	2	--	us2k¹		15		NS EA NA WA CSA	790
rs149139043^1,2		--	28972937(+)	`CTCACA/GGTTTT`	2	--	us2k¹		0	--	--	--	--
rs144943930^1,2		--	28972982(+)	`TTTACA/CCTGAT`	2	--	us2k¹		0	--	--	--	--
rs183286218^1,2		--	28973002(+)	`TATGTA/GAACTA`	2	--	us2k¹		0	--	--	--	--
rs112052499^1,2	C,	--	28973035(+)	`TAAAGT/CAGGGT`	2	--	us2k¹		2		NA	122
rs138161081^1,2		--	28973069(+)	`AAAGAA/GTGATG`	2	--	us2k¹		0	--	--	--	--
rs187632203^1,2		--	28973148(+)	`CTGCCC/TGTTCA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPP1CB (28974506 - 29025806 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP1CB: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPP1CB for disorders           About GeneDecksing

OMIM gene information: 600590    OMIM disorders: --

10 diseases for PPP1CB:    About MalaCards

intrahepatic cholangiocarcinoma insulin resistance cholangiocarcinoma retinoblastoma

breast cancer immunodeficiency melanoma malaria

neuronitis cardiac conduction defect

1 Novoseek disease relationship for PPP1CB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	11056045 (1)

Human Genome Epidemiology (HuGE) Navigator: PPP1CB (1 document)

Export disorders for PPP1CB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPP1CB gene, integrated from 9 sources (see all 97):
(articles sorted by number of sources associating them with PPP1CB)

Utopia: connect your pdf to the dynamic
world of online information

Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). (PubMed id 8312365)^{1, 2, 3} Barker H.M.... Cohen P.T.W. (1994)
Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. (PubMed id 7796987)^{1, 2, 9} Prochazka M.... Bogardus C. (1995)
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PubMed id 11399775)^{1, 2, 9} Tan I.... Leung T. (2001)
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PubMed id 20424263)^{1, 2} Li X....Ann D.K. (2010)
Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)^{1, 2} Lee J.H....Skalnik D.G. (2010)
GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461)^{1, 2} Fujiki R.... Kato S. (2009)
TIMAP is a positive regulator of pulmonary endothelial barrier function. (PubMed id 18586956)^{1, 2} Csortos C....Verin A.D. (2008)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5500	HGNC: 9282	AceView: PPP1CBandSPDY1	Ensembl:ENSG00000213639	euGenes: HUgn5500
ECgene: PPP1CB	Kegg: 5500	H-InvDB: PPP1CB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPP1CB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPP1CB	Genetics and Cytogenetics in Oncology and Haematology
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt032.shtml

Intellectual Property for PPP1CB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PPP1CB gene:
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GeneCards and IP:
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PPP1CB Gene

protein phosphatase 1, catalytic subunit, beta isozyme

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PPP1CB Gene

protein phosphatase 1, catalytic subunit, beta isozyme

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