Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PPP1CB Gene

protein-coding   GIFtS: 61
GCID: GC02P028974

Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme

(Previous names: protein phosphatase 1, catalytic subunit, beta isoform)
  See PPP1CB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme1 2     Epididymis Secretory Sperm Binding Protein Li 80p2
Protein Phosphatase 1, Catalytic Subunit, Beta Isoform1 2     Protein Phosphatase 1, Catalytic Subunit, Delta Isoform2
PP-1B2 3     Protein Phosphatase 1-Beta2
PPP1CD2 3     Protein Phosphatase 1-Delta2
EC 3.1.3.163 8     Serine/Threonine Protein Phosphatase PP1-Beta Catalytic Subunit2
HEL-S-80p2     Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit2
PP1B2     EC 3.1.3.533
PP1beta2     

External Ids:    HGNC: 92821   Entrez Gene: 55002   Ensembl: ENSG000002136397   OMIM: 6005905   UniProtKB: P621403   

Export aliases for PPP1CB gene to outside databases

Previous GC identifers: GC02P028895 GC02P029067 GC02P028949 GC02P028886 GC02P028829 GC02P028716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PPP1CB Gene:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a
serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular
processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral
transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively
spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1CB Gene:
PPP1CB (protein phosphatase 1, catalytic subunit, beta isozyme) is a protein-coding gene. Diseases associated with PPP1CB include cardiac conduction defect, and hiv-1. GO annotations related to this gene include protein kinase binding and myosin-light-chain-phosphatase activity. An important paralog of this gene is PPP1CA.

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell
division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1
phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during
the transition from mitosis into interphase

summary for PPP1CB Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP1CB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1CB gene promoter:
         TBP   Pax-5   GATA-3   COMP1   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP1CB promoter sequence
   Search Chromatin IP Primers for PPP1CB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1CB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23

PPP1CB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1CB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P028974:  view genomic region     (about GC identifiers)

Start:
28,974,506 bp from pter      End:
29,025,806 bp from pter
Size:
51,301 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit  
Size: 327 amino acids; 37187 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by
inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory
subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and
PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and
PPP1R3F (in brain) mediate binding to glycogen. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By
similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC,
HCFC1, ACTB and OGT. Interacts with PPP1R7 and PPP1R12C. PPP1R15A and PPP1R15B mediate binding to EIF2S1.
Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82,
and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with TRIM28; the interaction is weak. Interacts
with PPP1R12A and NUAK1; the interaction is direct
Secondary accessions: B2R5V4 D6W565 P37140 Q5U087 Q6FG45

Explore the universe of human proteins at neXtProt for PPP1CB: NX_P62140

Explore proteomics data for PPP1CB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys97, Lys112, Lys140, Lys146, Lys149, Lys167, Lys259, Lys303
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP1CB (P62140) (see all 23)
     RPTDVPD  RPVTPPR  CGDIHGQ  TFGADVV 


    See PPP1CB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002700.1  NP_996759.1  

    ENSEMBL proteins: 
     ENSP00000390715   ENSP00000398839   ENSP00000414918   ENSP00000394589   ENSP00000296122  
     ENSP00000378769   ENSP00000388056   ENSP00000351298  
    Reactome Protein details: P62140

    PPP1CB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPP1CB
    OriGene Protein Over-expression Lysate for PPP1CB
    OriGene MassSpec for PPP1CB
    OriGene Custom Protein Services for PPP1CB
    GenScript Custom Purified and Recombinant Proteins Services for PPP1CB
    Novus Biologicals PPP1CB Protein
    Novus Biologicals PPP1CB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PPP1CB 

     
    antibodies-online proteins for PPP1CB (13 products) 

     
    antibodies-online peptides for PPP1CB

    PPP1CB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP1CB
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PPP1CB
    OriGene Custom Antibody Services for PPP1CB
    Novus Biologicals PPP1CB Antibodies
    Abcam antibodies for PPP1CB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPP1CB
    antibodies-online antibodies for PPP1CB (76 products) 

    PPP1CB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP1CB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP1CB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPP1CB 
    antibodies-online kits for PPP1CB (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P62140

    ProtoNet protein and cluster: P62140

    UniProtKB/Swiss-Prot: PP1B_HUMAN, P62140
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    Find genes that share domains with PPP1CB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP1B_HUMAN, P62140
    Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
    holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell
    division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
    Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1
    phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during
    the transition from mitosis into interphase
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Catalytic activity: [Myosin light-chain] phosphate + H(2)O = [myosin light-chain] + phosphate
    Enzyme regulation: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The
    phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug
    that protects cells from endoplasmic reticulum stress

         Genatlas biochemistry entry for PPP1CB:
    serine/threonine protein phosphatase 1,catalytic subunit,beta

         Enzyme Numbers (IUBMB): EC 3.1.3.161 2 EC 3.1.3.531

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity ----
    GO:0005515protein binding IPI17511879
    GO:0016787hydrolase activity ----
    GO:0017018myosin phosphatase activity ISS--
    GO:0019901protein kinase binding IPI--
         
    Find genes that share ontologies with PPP1CB           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PPP1CB:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased cell number in G2M,   Nuclear pre-40S maturation def 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ppp1cb):
     mortality/aging 

    Find genes that share phenotypes with PPP1CB           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PPP1CB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP1CB:
    hsa-mir-505-3p (MIRT041041), hsa-mir-192-5p (MIRT026142), hsa-mir-15b-5p (MIRT046516), hsa-mir-92b-3p (MIRT040560), hsa-mir-615-3p (MIRT040166), hsa-mir-18a-5p (MIRT031341), hsa-mir-215-5p (MIRT024868), hsa-mir-23b-3p (MIRT046264)

    Block miRNA regulation of human, mouse, rat PPP1CB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1CB (see all 142):
    hsa-miR-411* hsa-miR-4275 hsa-miR-1243 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-99b hsa-miR-130a* hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidPPP1CB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP1CB
    Predesigned siRNA for gene silencing in human, mouse, rat PPP1CB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP1CB

    Clone
    Products:
         
    OriGene clones in human, mouse for PPP1CB (see all 11)
    OriGene ORF clones in mouse, rat for PPP1CB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PPP1CB (NM_002709)
    Sino Biological Human cDNA Clone for PPP1CB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1CB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CB
    Addgene plasmids for PPP1CB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP1CB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPP1CB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PP1B_HUMAN, P62140: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells
    and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from
    the nucleus to nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000164protein phosphatase type 1 complex ----
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0042587glycogen granule ----

    Find genes that share ontologies with PPP1CB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PPP1CB About   (see all 40)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF20.47
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    4Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    5Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70


    Find genes that share SuperPaths with PPP1CB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1CB (see all 9)
        Actin-Based Motility by Rho Family GTPases
    G-AlphaI Signaling
    Activation of PKC through GPCR
    Transendothelial Migration of Leukocytes
    Cellular Effects of Sildenafil

    1 Tocris Bioscience Pathway for PPP1CB
        Insulin Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PPP1CB (see all 13)
        Translation Regulation of EIF2 activity
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Translation Insulin regulation of translation

    2 BioSystems Pathways for PPP1CB
        G13 Signaling Pathway
    PLK1 signaling events


    3 Reactome Pathways for PPP1CB
        Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
    Regulation of PLK1 Activity at G2/M Transition
    Downregulation of TGF-beta receptor signaling


    Selected Kegg Pathways  (Kegg details for PPP1CB) (see all 16):
        mRNA surveillance pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP1CB: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP1CB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1CB (P621401, 2, 3 ENSP000002961224) via UniProtKB, MINT, STRING, and/or I2D (see all 370)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383981, 3, ENSP000003502834EBI-352350,EBI-349905 I2D: score=2 STRING: ENSP00000350283
    IKBKGQ9Y6K92, 3, ENSP000003586224MINT-48226 I2D: score=2 STRING: ENSP00000358622
    RIPK3Q9Y5722, 3MINT-49148 I2D: score=2 
    ENSG00000227720O609273, ENSP000004122974I2D: score=2 STRING: ENSP00000412297
    ENSG00000206501O609273I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0005977glycogen metabolic process IEA--
    GO:0005979regulation of glycogen biosynthetic process ----
    GO:0005981regulation of glycogen catabolic process ----

    Find genes that share ontologies with PPP1CB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP1CB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    6 HMDB Compounds for PPP1CB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    GlycogenAnimal starch (see all 5)9005-79-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PPP1CB gene (3 alternative transcripts): 
    NM_002709.2  NM_206876.1  NM_206877.1  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455580(uc010ymk.2) ENST00000420282 ENST00000441461 ENST00000427786
    ENST00000296122 ENST00000395366(uc002rmh.3) ENST00000464273 ENST00000418910
    ENST00000358506(uc010ymj.2 uc002rmg.3 uc010yml.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPP1CB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1CB (see all 142):
    hsa-miR-411* hsa-miR-4275 hsa-miR-1243 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-99b hsa-miR-130a* hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidPPP1CB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPP1CB
    Predesigned siRNA for gene silencing in human, mouse, rat PPP1CB
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP1CB (see all 11)
    OriGene ORF clones in mouse, rat for PPP1CB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PPP1CB (NM_002709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1CB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CB
    Addgene plasmids for PPP1CB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPP1CB
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1CB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP1CB
      QuantiTect SYBR Green Assays in human, mouse, rat PPP1CB
      QuantiFast Probe-based Assays in human, mouse, rat PPP1CB

    Selected AceView cDNA sequences (see all 727):

    BX487429 BM717982 X80910 BU683038 BC047224 AA742231 AA595792 BM564827 
    AL708540 AI354315 CR601128 BE047402 N62089 AI628919 BX647295 BU167697 
    BQ946172 AA292890 BU147113 AA442137 AI341812 AA281847 AU137881 BE670191 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PPP1CB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTGCTG
    PPP1CB Expression
    About this image


    PPP1CB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Limb (Muscoskeletal System)
             Zone Of Polarizing Activity Cells Limb Bud
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Mesoderm (Gastrulation Derivatives)
             Zone Of Polarizing Activity Cells Limb Bud
    PPP1CB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1CB Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including PPP1CB: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPP1CB
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP1CB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP1CB
    QuantiTect SYBR Green Assays in human, mouse, rat PPP1CB
    QuantiFast Probe-based Assays in human, mouse, rat PPP1CB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP1CB gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1cb1 , 5 protein phosphatase 1, catalytic subunit, beta isoform1, 5 94.6(n)1
    100(a)1
      5 (17.33 cM)5
    190461  NM_172707.31  NP_766295.21 
     324589745 
    chicken
    (Gallus gallus)
    Aves PPP1CB1 protein phosphatase 1, catalytic subunit, beta isozyme 87.56(n)
    100(a)
      396019  NM_205122.1  NP_990453.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1CB6
    protein phosphatase 1, catalytic subunit, beta iso...
    100(a)
    1 ↔ 1
    1(248252909-248285191)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU909047.12   -- 82.27(n)    BU909047.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA474593.12   -- 80.53(n)   368904  CA474593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta flw1 , 3 protein amino acid dephosphorylation
    protein serine/threonine more3
    flapwing1
    90(a)
    (best of 10)3
    71.44(n)1
    90.65(a)1
      442891  NM_001272478.11  NP_001259407.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C25A6.13
    gsp-11
    gsp-11 56(a)
    (best of 27)3
    75.27(n)1
    92.68(a)1
      V(5408340-5409883)3
    1794861  NM_001269321.11  NP_001256250.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLC76
    Type 1 serine/threonine protein phosphatase cataly...
    81(a)
    1 → many
    V(432495-433958) YER133W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOPP31 TOPP3 68.8(n)
    74.44(a)
      842708  NM_105077.3  NP_176587.1 
    rice
    (Oryza sativa)
    Liliopsida Os.121642 Oryza sativa protein phosphatase 1 mRNA, complete cds 75.51(n)    AK073140.1 


    ENSEMBL Gene Tree for PPP1CB (if available)
    TreeFam Gene Tree for PPP1CB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PPP1CB gene
    PPP1CA2  PPP1CC2  
    10 SIMAP similar genes for PPP1CB using alignment to 6 protein entries:     PP1B_HUMAN (see all proteins):
    PPP1CA    PPP1CC    PPP2CB    PPP2CA    PPP3CA    PPP3CB
    PPP6C    PPP3CC    PPP4C    PPP5C

    Find genes that share paralogs with PPP1CB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PPP1CB (see all 1128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167018881,2
    F--28972634(+) GGGCCC/TCATGA 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1452324841,2
    --28972816(+) ATCTTC/TTTCTT 2 -- us2k10--------
    rs111271881,2
    C,F,A,H--28972852(+) TGTGTA/GGCCTA 2 -- us2k115Minor allele frequency- G:0.42NS EA NA WA CSA 790
    rs1491390431,2
    --28972937(+) CTCACA/GGTTTT 2 -- us2k10--------
    rs1449439301,2
    --28972982(+) TTTACA/CCTGAT 2 -- us2k10--------
    rs1832862181,2
    C--28973002(+) TATGTA/GAACTA 2 -- us2k10--------
    rs1120524991,2
    C,F--28973035(+) TAAAGT/CAGGGT 2 -- us2k12Minor allele frequency- C:0.02NA 122
    rs1381610811,2
    C--28973069(+) AAAGAA/GTGATG 2 -- us2k10--------
    rs1876322031,2
    --28973148(+) CTGCCC/TGTTCA 2 -- us2k10--------
    rs2003809551,2
    C--28973187(+) ACTACC/TCCAGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP1CB (28974506 - 29025806 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PPP1CB: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1CB
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1CB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600590    OMIM disorders: --

    2 diseases for PPP1CB:    
    About MalaCards
    cardiac conduction defect    hiv-1


    Find genes that share disorders with PPP1CB           About GenesLikeMe

    1 Novoseek inferred disease relationship for PPP1CB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11056045 (1)

    Genetic Association Database (GAD): PPP1CB
    Human Genome Epidemiology (HuGE) Navigator: PPP1CB (1 document)

    Export disorders for PPP1CB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PPP1CB gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with PPP1CB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). (PubMed id 8312365)1, 2, 3 Barker H.M.... Cohen P.T.W. (Biochim. Biophys. Acta 1994)
    2. Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. (PubMed id 7796987)1, 2, 9 Prochazka M.... Bogardus C. (Diabetologia 1995)
    3. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PubMed id 11399775)1, 2, 9 Tan I.... Leung T. (J. Biol. Chem. 2001)
    4. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PubMed id 20424263)1, 2 Li X.... Ann D.K. (Sci. Signal. 2010)
    5. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H.... Skalnik D.G. (J. Biol. Chem. 2010)
    6. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    7. TIMAP is a positive regulator of pulmonary endothelial barrier function. (PubMed id 18586956)1, 2 Csortos C.... Verin A.D. (Am. J. Physiol. 2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5500 HGNC: 9282 AceView: PPP1CBandSPDY1 Ensembl:ENSG00000213639 euGenes: HUgn5500
    ECgene: PPP1CB Kegg: 5500 H-InvDB: PPP1CB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PPP1CB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1CB Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/032

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PPP1CB gene:
    Search GeneIP for patents involving PPP1CB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP1CB
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPP1CB   OriGene RNAi products in human, mouse, rat for PPP1CB  
     OriGene qPCR primer pairs and template standards for PPP1CB   OriGene Protein Over-expression Lysate for PPP1CB  
     OriGene MassSpec for PPP1CB   OriGene clones in human, mouse for PPP1CB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP1CB   OriGene Purified Protein for PPP1CB  
     OriGene ORF clones in mouse, rat for PPP1CB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP1CB   OriGene Custom Protein Services for PPP1CB  

     
     
     Block miRNA regulation of human, mouse, rat PPP1CB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPP1CB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1CB Predesigned siRNA for gene silencing in human, mouse, rat PPP1CB
     QuantiFast Probe-based Assays in human, mouse, rat PPP1CB QuantiTect SYBR Green Assays in human, mouse, rat PPP1CB
     PCR Arrays including human, mouse, rat PPP1CB Search Chromatin IP Primers for PPP1CB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP1CB  GeneGlobe Interaction Network for PPP1CB
     Regulatory tfbs in PPP1CB promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPP1CB GenScript cDNA clones with any tag delivered in your preferred vector for PPP1CB
     GenScript Custom Assay Services for PPP1CB GenScript Custom overexpressing Cell Line Services for PPP1CB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PPP1CB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PPP1CB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPP1CB antibodies
     PPP1CB proteins
     PPP1CB lysates
     Antibodies for PPP1CB
     See all of Abcam's Antibodies, Kits and Proteins for PPP1CB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPP1CB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CB
     SwitchGear 3'UTR luciferase reporter plasmids for PPP1CB
     SwitchGear Promoter luciferase reporter plasmids for PPP1CB
     ThermoFisher Antibody for PPP1CB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CB
     Browse compounds at ApexBio
     Addgene plasmids for PPP1CB
      Search eBioscience for proteins for PPP1CB
      Search eBioscience for elisas for PPP1CB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PPP1CB
     antibodies-online antibodies for PPP1CB (76 products)
     antibodies-online kits for PPP1CB (8 products)
     antibodies-online peptides for PPP1CB
     antibodies-online proteins for PPP1CB (13 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP1CB gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4