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PPP1CA Gene

protein-coding   GIFtS: 71
GCID: GC11M067165

Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme

(Previous names: protein phosphatase 1, catalytic subunit, alpha isoform)
(Previous symbol: PPP1A)
  See PPP1CA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme1 2     PP1A2
PPP1A1 2 3 5     PP1alpha2
Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform1 2     Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit2
PP-1A2 3     Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit2
EC 3.1.3.163 8     

External Ids:    HGNC: 92811   Entrez Gene: 54992   Ensembl: ENSG000001725317   OMIM: 1768755   UniProtKB: P621363   

Export aliases for PPP1CA gene to outside databases

Previous GC identifers: GC11M069698 GC11M068861 GC11M067415 GC11M066941 GC11M066922 GC11M063494


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1CA Gene:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a
serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular
processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral
transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human
and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1
functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP1CA Gene:
PPP1CA (protein phosphatase 1, catalytic subunit, alpha isozyme) is a protein-coding gene. Diseases associated with PPP1CA include hiv-1. GO annotations related to this gene include ribonucleoprotein complex binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP1CB.

UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for
cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein
synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important
role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent
protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin
structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function
in terms of kinase activity and centrosome number and splitting, both in the presence and absence of
radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell
(ENCCs) migration during development

summary for PPP1CA Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP1CA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1CA gene promoter:
         HEN1   AhR   p53   Sp1   Lmo2   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1CA promoter sequence
   Search Chromatin IP Primers for PPP1CA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

PPP1CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1CA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067165:  view genomic region     (about GC identifiers)

Start:
67,165,652 bp from pter      End:
67,188,654 bp from pter
Size:
23,003 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit  
Size: 330 amino acids; 37512 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by
inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory
subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in
liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By
similarity). Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts
with PHACTR4; which acts as an activator of PP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B;
the interactions mediate binding to EIF2S1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5,
STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex
with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5.
Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1
phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with
PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the
interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site. Interacts with
isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320. Interacts with
DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction
Selected PDB 3D structures from and Proteopedia for PPP1CA (see all 8):
3E7A (3D)        3E7B (3D)        3EGG (3D)        3EGH (3D)        3HVQ (3D)        3N5U (3D)    
Secondary accessions: A6NNR3 B2R908 P08129 P20653 P22802 Q07161
Alternative splicing: 3 isoforms:  P62136-1   P62136-2   P62136-3   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for PPP1CA: NX_P62136

Explore proteomics data for PPP1CA at MOPED

Post-translational modifications: 

  • Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation1
  • Ubiquitination2 at Lys6, Lys26, Lys98, Lys113, Lys141, Lys147, Lys150, Lys168, Lys238, Lys260,
                                 Lys305
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP1CA (P62136) (see all 22)
     PGKNVQL  RPTDVPD  CGDIHGQ  CSFQILK 


    See PPP1CA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008709.1  NP_002699.1  NP_996756.1  

    ENSEMBL proteins: 
     ENSP00000326031   ENSP00000365936   ENSP00000350974   ENSP00000431146   ENSP00000439568  
     ENSP00000438409  
    Reactome Protein details: P62136

    PPP1CA Human Recombinant Protein Products:

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    OriGene Purified Proteins for PPP1CA
    OriGene Protein Over-expression Lysate for PPP1CA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPP1CA
    GenScript Custom Purified and Recombinant Proteins Services for PPP1CA
    Novus Biologicals PPP1CA Proteins
    Novus Biologicals PPP1CA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPP1CA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PPP1CA 

    PPP1CA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP1CA
    R&D Systems Antibodies for PPP1CA (PP1 alpha, PP1)
    Cell Signaling Technology (CST) Antibodies for PPP1CA 
    OriGene Antibodies for PPP1CA
    OriGene Custom Antibody Services for PPP1CA
    Novus Biologicals PPP1CA Antibodies
    Abcam antibodies for PPP1CA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPP1CA
    LSBio Antibodies in human, mouse, rat for PPP1CA

    PPP1CA Assay Products:

    EMD Millipore Kits and Assays for the Analysis of PPP1CA
    OriGene Custom Assay Services for PPP1CA
    R&D Systems Enzyme Activity Assays & Reagents for PPP1CA (PP1)
    GenScript Custom Assay Services for PPP1CA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPP1CA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P62136

    ProtoNet protein and cluster: P62136

    UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    Find genes that share domains with PPP1CA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP1A_HUMAN, P62136
    Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific
    holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for
    cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein
    synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important
    role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent
    protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin
    structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function
    in terms of kinase activity and centrosome number and splitting, both in the presence and absence of
    radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell
    (ENCCs) migration during development
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Enzyme regulation: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by
    Salubrinal, a drug that protects cells from endoplasmic reticulum stress

         Genatlas biochemistry entry for PPP1CA:
    serine/threonine protein phosphatase 1,catalytic subunit,alpha,involved in mitotic exit

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0005515protein binding IPI10807923
    GO:0016787hydrolase activity ----
    GO:0043021ribonucleoprotein complex binding IEA--
         
    Find genes that share ontologies with PPP1CA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP1CA:
     Increased Erk phosphorylation   Increased apoptosis 

         1 MGI phenotypic allele for Ppp1ca (no phenotypes)

    Find genes that share phenotypes with PPP1CA           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP1CA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP1CA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP1CA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP1CA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP1CA:
    hsa-mir-192-5p (MIRT026892), hsa-mir-744-5p (MIRT037406), hsa-mir-769-5p (MIRT016090), hsa-mir-215-5p (MIRT024705), hsa-mir-17-5p (MIRT051034)

    Block miRNA regulation of human, mouse, rat PPP1CA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP1CA (see all 11):
    hsa-miR-3194-5p hsa-miR-125a-5p hsa-miR-4272 hsa-miR-4267 hsa-miR-3160-3p hsa-miR-664 hsa-miR-1184 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidPPP1CA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP1CA
    Predesigned siRNA for gene silencing in human, mouse, rat PPP1CA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP1CA

    Clone
    Products:
         
    OriGene clones in human, mouse for PPP1CA (see all 17)
    OriGene ORF clones in mouse, rat for PPP1CA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPP1CA (NM_002708)
    Sino Biological Human cDNA Clone for PPP1CA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CA
    Addgene plasmids for PPP1CA 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PPP1CA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP1A_HUMAN, P62136: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and
    largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with
    targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8
    relocalizes from the nucleus to nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000164protein phosphatase type 1 complex IEA--
    GO:0005634nucleus IDA11739654
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA11739654

    Find genes that share ontologies with PPP1CA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1CA About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF20.47
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    2Ca-dependent events
    Opioid Signalling0.54
    Signal transduction Calcium signaling0.35
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    4Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32
    5Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60


    Find genes that share SuperPaths with PPP1CA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PPP1CA
        Phosphatases
    Cell Cycle / Checkpoint Control

    1 Tocris Bioscience Pathway for PPP1CA
        Insulin Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PPP1CA (see all 7)
        Apoptosis and survival BAD phosphorylation
    Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Transcription CREB pathway
    Translation Regulation of EIF2 activity

    4 BioSystems Pathways for PPP1CA
        Nicotine Activity on Dopaminergic Neurons
    BMP receptor signaling
    TGF-beta receptor signaling
    ALK1 signaling events


    3 Reactome Pathways for PPP1CA
        Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
    DARPP-32 events
    Downregulation of TGF-beta receptor signaling

    1 PharmGKB Pathway for PPP1CA
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PPP1CA) (see all 16):
        mRNA surveillance pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP1CA: 
              Insulin Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP1CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1CA (P621361, 2, 3 ENSP000003260314) via UniProtKB, MINT, STRING, and/or I2D (see all 1319)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R9BQ96SB31, 2, 3EBI-357253,EBI-351275 MINT-8290898 MINT-62199 MINT-8290911 MINT-8290954 I2D: score=5 
    PPP1R8Q129721, 2, 3, ENSP000003116774EBI-357253,EBI-716633 MINT-8292686 MINT-8338344 MINT-62188 I2D: score=4 STRING: ENSP00000311677
    SGOL2Q562F61, 2, 3EBI-357253,EBI-989213 MINT-8212643 MINT-8212619 MINT-8212589 MINT-8210383 I2D: score=1 
    SPRED1Q7Z6991, 2, 3, ENSP000002990844EBI-357253,EBI-5235340 MINT-62190 I2D: score=3 STRING: ENSP00000299084
    ENSG00000238104Q96QC02, 3, ENSP000004073104MINT-62189 I2D: score=4 STRING: ENSP00000407310
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--
    GO:0005979regulation of glycogen biosynthetic process IEA--
    GO:0005981regulation of glycogen catabolic process IEA--
    GO:0006470protein dephosphorylation IEA--
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with PPP1CA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP1CA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    4 HMDB Compounds for PPP1CA    About this table
    CompoundSynonyms CAS #PubMed Ids
    GlycogenAnimal starch (see all 5)9005-79-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    1 DrugBank Compound for PPP1CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1CA gene (3 alternative transcripts): 
    NM_001008709.1  NM_002708.3  NM_206873.1  

    Unigene Cluster for PPP1CA:

    Protein phosphatase 1, catalytic subunit, alpha isozyme
    Hs.183994  [show with all ESTs]
    Unigene Representative Sequence: AK098311
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312989(uc001okx.1) ENST00000532446 ENST00000526510 ENST00000376745(uc001oku.1 uc001okv.1 uc001okw.1)
    ENST00000358239 ENST00000532279 ENST00000527663 ENST00000537694 ENST00000529724
    ENST00000546202 ENST00000542876
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    Additional mRNA sequence: 

    AK098311.1 AK127616.1 AK313586.1 BC001888.1 BC004482.2 BC008010.1 BT006629.1 J04759.1 
    M63960.1 S57501.1 X70848.1 

    Selected DOTS entries (see all 28):

    DT.92465318  DT.100884968  DT.100884945  DT.100760796  DT.100884978  DT.100884941  DT.450687  DT.97855870 
    DT.100884952  DT.80100500  DT.120703507  DT.100884967  DT.97796802  DT.100884977  DT.120703503  DT.92465301 
    DT.100884942  DT.97804697  DT.100884979  DT.100808596  DT.100884983  DT.120703613  DT.100733566  DT.120703618 

    Selected AceView cDNA sequences (see all 931):

    CR595203 BQ898971 R54872 BU147403 BI093338 CA454025 BQ218606 CR594209 
    BQ680480 BP356412 CR612914 BP335237 AI346103 BQ691772 BQ937844 AW406812 
    BQ228364 CD673528 BQ435111 BI757203 AW575359 BT006629 BQ424532 BM558368 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CA (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a · 9b
    SP1:                    -     -     -                                                                                                         
    SP2:                    -     -     -                                                                                                         
    SP3:                    -     -     -     -     -                                                                                             
    SP4:                    -     -                                                                                                               
    SP5:                    -     -     -                                   -                                                                     


    ECgene alternative splicing isoforms for PPP1CA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPP1CA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCTTGGT
    PPP1CA Expression
    About this image


    PPP1CA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebellum
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    PPP1CA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1CA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183994
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP1CA: 
              Insulin Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP1CA gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1ca1 , 5 protein phosphatase 1, catalytic subunit, alpha isoform1, 5 90.1(n)1
    99.7(a)1
      19 (3.89 cM)5
    190451  NM_031868.21  NP_114074.11 
     41921745 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1CA6
    protein phosphatase 1, catalytic subunit, alpha is...
    99(a)
    1 ↔ 1
    1(93138239-93156073)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppp1ca-prov2 Protein phosphatase type 1 alpha, catalytic subunit 84(n)    BC041730.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp1caa1 protein phosphatase 1, catalytic subunit, alpha isoform more 78.25(n)
    91.46(a)
      407980  NM_214811.2  NP_999976.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pp1-87B3 adult locomotory behavior protein
    serine/threonine more
    93(a)
    (best of 10)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea C25A6.13
    gsp-21
    gsp-21 55(a)
    (best of 28)3
    74.67(n)1
    91.08(a)1
      V(5408340-5409883)3
    35648071  NM_001027445.41  NP_001022616.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPQ1(YPL179W)4
    GLC71
    Putative protein serine/threonine phosphatase; null more4
    GLC71
    65.89(n)1
    85.67(a)1
      16(208157-209806)4
    8568701  NP_011059.31  8559234 
     NP_015146.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOPP21 TOPP2 68.37(n)
    80.89(a)
      836034  NM_180887.4  NP_851218.1 
    rice
    (Oryza sativa)
    Liliopsida Os.63592 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 79.4(n)    AK121378.1 


    ENSEMBL Gene Tree for PPP1CA (if available)
    TreeFam Gene Tree for PPP1CA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1CA gene
    PPP1CB2  PPP1CC2  
    10 SIMAP similar genes for PPP1CA using alignment to 7 protein entries:     PP1A_HUMAN (see all proteins):
    PPP1CC    PPP1CB    PPP2CA    PPP2CB    PPP6C    PPP3CB
    PPP3CA    PPP4C    PPP5C    PPP3CC

    Find genes that share paralogs with PPP1CA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PPP1CA
    PGOHUM00000243303


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1CA (see all 79)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012174721,2
    --67165215(+) CTGGG-/CCCCGTT 2 -- ds50010--------
    rs38327771,2
    C--67165217(+) GGGCCCT/-GTTAT 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs2008144031,2
    C--67166388(+) CTGCCA/GCAGGC 3 -- int10--------
    rs1998191691,2
    C--67166395(+) AGGCCA/GGAGCC 3 -- int10--------
    rs2015295621,2
    C--67166403(+) GCCACC/AAGCCC 3 -- int11Minor allele frequency- A:0.00EU 1321
    rs1426012061,2
    F--67166548(+) CAGCAG/AGTCAC 6 /L syn11Minor allele frequency- A:0.00NA 4536
    rs118275711,2
    C,F,H--67166645(+) GGGCCG/AGGGGA 3 -- int114Minor allele frequency- A:0.03NS EA NA WA 1904
    rs2010185611,2
    --67166652(+) GGGAAC/GGTCAC 3 -- int10--------
    rs178828941,2
    C,F,H--67166753(+) TGGGCG/ACCTAG 3 -- int17Minor allele frequency- A:0.06NS NA WA 1082
    rs1131689591,2
    F--67166924(+) GTATGG/CGGGAC 3 -- int12Minor allele frequency- C:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for PPP1CA (67165652 - 67188654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PPP1CA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516453CNV Loss19592680
    nsv897796CNV Loss21882294
    dgv1195n71CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897811CNV Loss21882294
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897804CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 176875    OMIM disorders: --

    1 disease for PPP1CA:    
    About MalaCards
    hiv-1


    Find genes that share disorders with PPP1CA           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: PPP1CA (1 document)

    Export disorders for PPP1CA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1CA gene, integrated from 10 sources (see all 185):
    (articles sorted by number of sources associating them with PPP1CA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H.... Skalnik D.G. (J. Biol. Chem. 2010)
    2. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PubMed id 20424263)1, 2 Li X.... Ann D.K. (Sci. Signal. 2010)
    3. Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors. (PubMed id 18992256)1, 2 Kelker M.S.... Peti W. (J. Mol. Biol. 2009)
    4. NOM1 targets protein phosphatase I to the nucleolus. (PubMed id 17965019)1, 2 Gunawardena S.R.... Conklin K.F. (J. Biol. Chem. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Protein phosphatase 1 -- targeted in many directions. (PubMed id 11839776)1, 2 Cohen P.T.W. (J. Cell Sci. 2002)
    8. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PubMed id 12226088)1, 2 Ceulemans H....Bollen M. (J. Biol. Chem. 2002)
    9. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PubMed id 11564868)1, 2 Connor J.H.... Shenolikar S. (Mol. Cell. Biol. 2001)
    10. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. (PubMed id 11739654)1, 2 Trinkle-Mulcahy L.... Lamond A.I. (J. Cell Sci. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5499 HGNC: 9281 AceView: PPP1CA Ensembl:ENSG00000172531 euGenes: HUgn5499
    ECgene: PPP1CA Kegg: 5499 H-InvDB: PPP1CA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP1CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1CA Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/032

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP1CA gene:
    Search GeneIP for patents involving PPP1CA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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