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Aliases for PPP1CA Gene

Aliases for PPP1CA Gene

  • Protein Phosphatase 1 Catalytic Subunit Alpha 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme 2 3 5
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform 2 3
  • EC 3.1.3.16 4 63
  • PPP1A 3 4
  • PP-1A 3 4
  • Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit 3
  • Testicular Tissue Protein Li 155 3
  • PP1alpha 3
  • PP1A 3

External Ids for PPP1CA Gene

Previous HGNC Symbols for PPP1CA Gene

  • PPP1A

Previous GeneCards Identifiers for PPP1CA Gene

  • GC11M069698
  • GC11M068861
  • GC11M066941
  • GC11M066922
  • GC11M067165
  • GC11M063494

Summaries for PPP1CA Gene

Entrez Gene Summary for PPP1CA Gene

  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1CA Gene

PPP1CA (Protein Phosphatase 1 Catalytic Subunit Alpha) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP1CC.

UniProtKB/Swiss-Prot for PPP1CA Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CA Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP1CA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1CA Gene

Genomics for PPP1CA Gene

Regulatory Elements for PPP1CA Gene

Enhancers for PPP1CA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1CA on UCSC Golden Path with GeneCards custom track

Promoters for PPP1CA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1CA on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1CA Gene

Chromosome:
11
Start:
67,398,181 bp from pter
End:
67,421,183 bp from pter
Size:
23,003 bases
Orientation:
Minus strand

Genomic View for PPP1CA Gene

Genes around PPP1CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CA Gene

Proteins for PPP1CA Gene

  • Protein details for PPP1CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62136-PP1A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Protein Accession:
    P62136
    Secondary Accessions:
    • A6NNR3
    • B2R908
    • P08129
    • P20653
    • P22802
    • Q07161

    Protein attributes for PPP1CA Gene

    Size:
    330 amino acids
    Molecular mass:
    37512 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity)Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PHACTR4; which acts as an activator of PP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on Ser-824 and forms a complex at the p21 promoter site. Interacts with isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320. Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with FOXP3.

    Three dimensional structures from OCA and Proteopedia for PPP1CA Gene

    Alternative splice isoforms for PPP1CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CA Gene

Proteomics data for PPP1CA Gene at MOPED

Post-translational modifications for PPP1CA Gene

  • Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.
  • Ubiquitination at Lys 26 and Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1CA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP1CA (PPP1CA)

Domains & Families for PPP1CA Gene

Gene Families for PPP1CA Gene

Graphical View of Domain Structure for InterPro Entry

P62136

UniProtKB/Swiss-Prot:

PP1A_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CA: view

Function for PPP1CA Gene

Molecular function for PPP1CA Gene

GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,alpha,involved in mitotic exit
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Enzyme Numbers (IUBMB) for PPP1CA Gene

Gene Ontology (GO) - Molecular Function for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10807923
GO:0016787 hydrolase activity IEA --
GO:0043021 ribonucleoprotein complex binding IEA --
genes like me logo Genes that share ontologies with PPP1CA: view
genes like me logo Genes that share phenotypes with PPP1CA: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CA Gene

Localization for PPP1CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CA Gene

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1CA Gene COMPARTMENTS Subcellular localization image for PPP1CA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IDA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PPP1CA: view

Pathways & Interactions for PPP1CA Gene

genes like me logo Genes that share pathways with PPP1CA: view

SIGNOR curated interactions for PPP1CA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,ISS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0019433 triglyceride catabolic process TAS --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS --
GO:0032091 negative regulation of protein binding ISS --
genes like me logo Genes that share ontologies with PPP1CA: view

Drugs & Compounds for PPP1CA Gene

(8) Drugs for PPP1CA Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
microcystin-lr Pharma Inhibitor of protein phosphatase PP1/PP2A,potent and selective 0
Sal 003 Pharma Cellular phosphatase complex inhibitor 0

(7) Additional Compounds for PPP1CA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(5) Tocris Compounds for PPP1CA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8

(2) ApexBio Compounds for PPP1CA Gene

Compound Action Cas Number
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP1CA: view

Transcripts for PPP1CA Gene

Unigene Clusters for PPP1CA Gene

Protein phosphatase 1, catalytic subunit, alpha isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -
SP8:
SP9: - - - -
SP10:

Relevant External Links for PPP1CA Gene

GeneLoc Exon Structure for
PPP1CA
ECgene alternative splicing isoforms for
PPP1CA

Expression for PPP1CA Gene

mRNA expression in normal human tissues for PPP1CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1CA Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for PPP1CA Gene

This gene is overexpressed in Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1CA Gene



SOURCE GeneReport for Unigene cluster for PPP1CA Gene Hs.183994

genes like me logo Genes that share expression patterns with PPP1CA: view

Protein tissue co-expression partners for PPP1CA Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PPP1CA Gene

Orthologs for PPP1CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1CA 35
  • 93.03 (n)
  • 100 (a)
PPP1CA 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1CA 35
  • 92.93 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Ppp1ca 35
  • 90.1 (n)
  • 99.7 (a)
Ppp1ca 16
Ppp1ca 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1CA 35
  • 99.7 (n)
  • 100 (a)
PPP1CA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1ca 35
  • 90.3 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1CA 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CA 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1CA 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6652 35
African clawed frog
(Xenopus laevis)
Amphibia ppp1ca-prov 35
zebrafish
(Danio rerio)
Actinopterygii ppp1caa 35
  • 78.25 (n)
  • 91.46 (a)
ppp1caa 36
  • 90 (a)
ManyToMany
ppp1cab 36
  • 89 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9837 35
fruit fly
(Drosophila melanogaster)
Insecta flw 37
  • 84 (a)
Pp1-13C 37
  • 91 (a)
Pp1-87B 37
  • 93 (a)
Pp1-Y2 37
  • 74 (a)
Pp1alpha-96A 37
  • 88 (a)
Pp1rY1 37
  • 59 (a)
PpD5 37
  • 64 (a)
PpD6 37
  • 60 (a)
PpN58A 37
  • 63 (a)
PpY-55A 37
  • 64 (a)
Pp1-13C 36
  • 91 (a)
ManyToMany
Pp1-87B 36
  • 93 (a)
ManyToMany
Pp1alpha-96A 36
  • 88 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C06A1.3 37
  • 47 (a)
C09H5.7 37
  • 48 (a)
C23G10.1a 37
  • 46 (a)
C23G10.1b 37
  • 46 (a)
C24H11.1 37
  • 48 (a)
C24H11.2 37
  • 48 (a)
C25A6.1 37
  • 55 (a)
C27B7.6 37
  • 41 (a)
C30A5.4 37
  • 32 (a)
C34D4.2 37
  • 52 (a)
C47A4.3 37
  • 52 (a)
F22D6.9 37
  • 40 (a)
F23B12.1 37
  • 53 (a)
F25B3.4 37
  • 55 (a)
F42G8.8 37
  • 36 (a)
F49E11.7 37
  • 38 (a)
F52H3.6 37
  • 54 (a)
F58G1.3 37
  • 43 (a)
R08A2.2 37
  • 38 (a)
R13A5.11 37
  • 42 (a)
T03F1.5 37
  • 53 (a)
T25B9.2 37
  • 41 (a)
W03D8.2 37
  • 47 (a)
W09C3.6 37
  • 54 (a)
Y40H4A.2 37
  • 38 (a)
Y69E1A.4 37
  • 41 (a)
ZC477.2 37
  • 33 (a)
ZK354.9 37
  • 53 (a)
gsp-2 35
  • 74.67 (n)
  • 91.08 (a)
Y71G12B.30 36
  • 46 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR166C 35
  • 75.27 (n)
  • 83.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12496g 35
  • 65.77 (n)
  • 84.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 35
  • 65.89 (n)
  • 85.67 (a)
GLC7 36
  • 84 (a)
OneToMany
PPQ1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TOPP2 35
  • 68.37 (n)
  • 80.89 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1740 35
rice
(Oryza sativa)
Liliopsida Os.6359 35
Os02g0820000 35
  • 69.82 (n)
  • 79.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14255 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11530 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00043 35
  • 75.03 (n)
  • 86.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dis2 35
  • 68.35 (n)
  • 84.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7187 36
  • 92 (a)
OneToMany
Species with no ortholog for PPP1CA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP1CA Gene

ENSEMBL:
Gene Tree for PPP1CA (if available)
TreeFam:
Gene Tree for PPP1CA (if available)

Paralogs for PPP1CA Gene

Paralogs for PPP1CA Gene

Pseudogenes.org Pseudogenes for PPP1CA Gene

genes like me logo Genes that share paralogs with PPP1CA: view

Variants for PPP1CA Gene

Sequence variations from dbSNP and Humsavar for PPP1CA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2286620 -- 67,399,513(+) GGTGC(C/T)GAGGG intron-variant
rs2286621 -- 67,399,673(+) GCCCA(A/C/G)GGGGA intron-variant
rs11542939 -- 67,400,837(-) TTTCT(A/G)GGGGA reference, synonymous-codon
rs11827571 -- 67,399,174(+) GGGCC(A/G)GGGGA intron-variant
rs61891591 -- 67,400,053(+) AATCG(A/C)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1CA Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv516453 CNV Loss 19592680
dgv1195n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294

Variation tolerance for PPP1CA Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1CA Gene

HapMap Linkage Disequilibrium report
PPP1CA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1CA Gene

Disorders for PPP1CA Gene

Relevant External Links for PPP1CA

Human Genome Epidemiology (HuGE) Navigator
PPP1CA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1CA

No disorders were found for PPP1CA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1CA Gene

Publications for PPP1CA Gene

  1. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-I+ in rheumatoid arthritis. (PMID: 23396208) Nie H. … Zhang J.Z. (Nat. Med. 2013) 3 4 67
  2. Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation. (PMID: 26636645) Liu X. … Chen S. (Oncotarget 2016) 3
  3. Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments. (PMID: 24902662) Ferreira-Fernandes E. … da Cruz e Silva O.A. (J. Mol. Neurosci. 2015) 3
  4. The natural tumorcide Manumycin-A targets protein phosphatase 1I+ and reduces hydrogen peroxide to induce lymphoma apoptosis. (PMID: 25556058) Carey G.B. … Daino H. (Exp. Cell Res. 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for PPP1CA Gene

Sources for PPP1CA Gene

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