Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1CA Gene

Aliases for PPP1CA Gene

  • Protein Phosphatase 1 Catalytic Subunit Alpha 2 3 5
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme 2 3
  • EC 3.1.3.16 4 61
  • PPP1A 3 4
  • PP-1A 3 4
  • Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit 3
  • Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit 3
  • Testicular Tissue Protein Li 155 3
  • PP1alpha 3
  • PP1A 3

External Ids for PPP1CA Gene

Previous HGNC Symbols for PPP1CA Gene

  • PPP1A

Previous GeneCards Identifiers for PPP1CA Gene

  • GC11M069698
  • GC11M068861
  • GC11M066941
  • GC11M066922
  • GC11M067165
  • GC11M063494

Summaries for PPP1CA Gene

Entrez Gene Summary for PPP1CA Gene

  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1CA Gene

PPP1CA (Protein Phosphatase 1 Catalytic Subunit Alpha) is a Protein Coding gene. Among its related pathways are Development Ligand-independent activation of ESR1 and ESR2 and Metabolism. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP1CC.

UniProtKB/Swiss-Prot for PPP1CA Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the Ser-139 residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).

Tocris Summary for PPP1CA Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP1CA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1CA Gene

Genomics for PPP1CA Gene

Regulatory Elements for PPP1CA Gene

Enhancers for PPP1CA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F067385 0.6 Ensembl 12 +35.9 35883 0.6 PRDM10 CARNS1 RN7SKP239 POLD4 SSH3 PPP1CA PTPRCAP RPS6KB2 ENSG00000255949 PIR46028 ENSG00000275484
GH11F067378 0.6 Ensembl ENCODE 12 +40.5 40483 5.0 HDGF ATF1 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF48 ZNF2 ZNF121 PTPRCAP CARNS1 SSH3 POLD4 PPP1CA RPS6KB2 ENSG00000255949 RBM4B TBC1D10C RAD9A
GH11F067316 0.5 ENCODE 11.7 +103.6 103613 2.3 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 CLCF1 MRPL11 LRP5 RHOD GRK2 SSH3 POLD4 RN7SKP239 ENSG00000256514 RNU6-1238P
GH11F067347 1.1 Ensembl ENCODE 11.6 +72.1 72083 2.6 PKNOX1 ARNT CREB3L1 ARID4B ZNF48 YY1 ELK1 GATA2 JUNB NCOA1 ENSG00000258297 ENSG00000256514 CLCF1 RBM4B RAD9A RNU6-1238P TBC1D10C SSH3 CARNS1 PPP1CA
GH11F067338 0.5 FANTOM5 11.4 +82.5 82509 0.3 PKNOX1 RN7SKP239 ENSG00000256514 CLCF1 SSH3 ANKRD13D PPP1CA PTPRCAP RPS6KB2 ENSG00000255949 RHOD
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPP1CA on UCSC Golden Path with GeneCards custom track

Promoters for PPP1CA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000564199 83 1001 PKNOX1 ATF1 CREB3L1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 SP3 SP5

Genomic Location for PPP1CA Gene

Chromosome:
11
Start:
67,398,181 bp from pter
End:
67,421,183 bp from pter
Size:
23,003 bases
Orientation:
Minus strand

Genomic View for PPP1CA Gene

Genes around PPP1CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CA Gene

Proteins for PPP1CA Gene

  • Protein details for PPP1CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62136-PP1A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Protein Accession:
    P62136
    Secondary Accessions:
    • A6NNR3
    • B2R908
    • P08129
    • P20653
    • P22802
    • Q07161

    Protein attributes for PPP1CA Gene

    Size:
    330 amino acids
    Molecular mass:
    37512 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PHACTR4; which acts as an activator of PP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on Ser-824 and forms a complex at the p21 promoter site. Interacts with isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320. Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with FOXP3 (PubMed:23396208). Interacts with CENPA (PubMed:25556658). Interacts with ATG16L1 (PubMed:26083323).

    Three dimensional structures from OCA and Proteopedia for PPP1CA Gene

    Alternative splice isoforms for PPP1CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CA Gene

Selected DME Specific Peptides for PPP1CA Gene

P62136:
  • KIKYPENFF
  • PGKNVQL
  • RPTDVPD
  • VVEDGYEFF
  • CSFQILK
  • DLLWSDP
  • YGFYDEC
  • FSAPNYCGEFDN
  • IFCCHGGLSP
  • ETICLLLAYK
  • GRPITPPR
  • CKRRYNI
  • NFFLLRGNHE
  • DLICRAH
  • GWGENDRGVS
  • CGDIHGQ
  • DLLRLFEYGGFPP
  • GDYVDRG
  • GLLCDLLW
  • FTDCFNCLP
  • GEFDNAGAMM
  • LLELEAP

Post-translational modifications for PPP1CA Gene

  • Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.
  • Ubiquitination at Lys 26 and Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1CA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP1CA (PPP1CA)
  • Cloud-Clone Corp. Antibodies for PPP1CA

Domains & Families for PPP1CA Gene

Gene Families for PPP1CA Gene

Graphical View of Domain Structure for InterPro Entry

P62136

UniProtKB/Swiss-Prot:

PP1A_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CA: view

Function for PPP1CA Gene

Molecular function for PPP1CA Gene

GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,alpha,involved in mitotic exit
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the Ser-139 residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Enzyme Numbers (IUBMB) for PPP1CA Gene

Gene Ontology (GO) - Molecular Function for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,ISS --
GO:0004722 protein serine/threonine phosphatase activity IEA,TAS --
GO:0005515 protein binding IPI 10807923
GO:0008157 protein phosphatase 1 binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP1CA: view
genes like me logo Genes that share phenotypes with PPP1CA: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CA Gene

Localization for PPP1CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CA Gene

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1CA Gene COMPARTMENTS Subcellular localization image for PPP1CA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IEA,IDA 11739654
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with PPP1CA: view

Pathways & Interactions for PPP1CA Gene

genes like me logo Genes that share pathways with PPP1CA: view

SIGNOR curated interactions for PPP1CA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0005981 regulation of glycogen catabolic process IEA --
GO:0006470 protein dephosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with PPP1CA: view

Drugs & Compounds for PPP1CA Gene

(13) Drugs for PPP1CA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 915
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0

(4) Additional Compounds for PPP1CA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
FK 506
104987-11-3

(5) Tocris Compounds for PPP1CA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
Tautomycetin Selective PP1 inhibitor 119757-73-2

(3) ApexBio Compounds for PPP1CA Gene

Compound Action Cas Number
Cantharidin Inhibitor of protein phosphatases 1/2A 56-25-7
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP1CA: view

Transcripts for PPP1CA Gene

Unigene Clusters for PPP1CA Gene

Protein phosphatase 1, catalytic subunit, alpha isozyme:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -
SP8:
SP9: - - - -
SP10:

Relevant External Links for PPP1CA Gene

GeneLoc Exon Structure for
PPP1CA
ECgene alternative splicing isoforms for
PPP1CA

Expression for PPP1CA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1CA Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for PPP1CA Gene

This gene is overexpressed in Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1CA Gene



Protein tissue co-expression partners for PPP1CA Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1CA Gene:

PPP1CA

SOURCE GeneReport for Unigene cluster for PPP1CA Gene:

Hs.183994
genes like me logo Genes that share expression patterns with PPP1CA: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PPP1CA Gene

Orthologs for PPP1CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1CA 34 35
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia PPP1CA 34 35
  • 93.03 (n)
dog
(Canis familiaris)
Mammalia PPP1CA 34
  • 92.93 (n)
rat
(Rattus norvegicus)
Mammalia Ppp1ca 34
  • 90.3 (n)
mouse
(Mus musculus)
Mammalia Ppp1ca 34 16 35
  • 90.1 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP1CA 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CA 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1CA 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6652 34
African clawed frog
(Xenopus laevis)
Amphibia ppp1ca-prov 34
zebrafish
(Danio rerio)
Actinopterygii ppp1cab 35
  • 89 (a)
ManyToMany
ppp1caa 34 35
  • 78.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9837 34
fruit fly
(Drosophila melanogaster)
Insecta Pp1-87B 36 35
  • 93 (a)
Pp1-13C 36 35
  • 91 (a)
Pp1alpha-96A 36 35
  • 88 (a)
flw 36
  • 84 (a)
Pp1-Y2 36
  • 74 (a)
PpD5 36
  • 64 (a)
PpY-55A 36
  • 64 (a)
PpN58A 36
  • 63 (a)
PpD6 36
  • 60 (a)
Pp1rY1 36
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea gsp-2 34
  • 74.67 (n)
C25A6.1 36
  • 55 (a)
F25B3.4 36
  • 55 (a)
F52H3.6 36
  • 54 (a)
W09C3.6 36
  • 54 (a)
F23B12.1 36
  • 53 (a)
T03F1.5 36
  • 53 (a)
ZK354.9 36
  • 53 (a)
C34D4.2 36
  • 52 (a)
C47A4.3 36
  • 52 (a)
C09H5.7 36
  • 48 (a)
C24H11.1 36
  • 48 (a)
C24H11.2 36
  • 48 (a)
C06A1.3 36
  • 47 (a)
W03D8.2 36
  • 47 (a)
C23G10.1a 36
  • 46 (a)
C23G10.1b 36
  • 46 (a)
Y71G12B.30 35
  • 46 (a)
ManyToMany
F58G1.3 36
  • 43 (a)
R13A5.11 36
  • 42 (a)
C27B7.6 36
  • 41 (a)
T25B9.2 36
  • 41 (a)
Y69E1A.4 36
  • 41 (a)
F22D6.9 36
  • 40 (a)
F49E11.7 36
  • 38 (a)
R08A2.2 36
  • 38 (a)
Y40H4A.2 36
  • 38 (a)
F42G8.8 36
  • 36 (a)
ZC477.2 36
  • 33 (a)
C30A5.4 36
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR166C 34
  • 75.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 34 35
  • 65.89 (n)
PPQ1 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12496g 34
  • 65.77 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TOPP2 34
  • 68.37 (n)
rice
(Oryza sativa)
Liliopsida Os02g0820000 34
  • 69.82 (n)
Os.6359 34
barley
(Hordeum vulgare)
Liliopsida Hv.1740 34
wheat
(Triticum aestivum)
Liliopsida Ta.14255 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7187 35
  • 92 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00043 34
  • 75.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dis2 34
  • 68.35 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11530 34
Species where no ortholog for PPP1CA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP1CA Gene

ENSEMBL:
Gene Tree for PPP1CA (if available)
TreeFam:
Gene Tree for PPP1CA (if available)

Paralogs for PPP1CA Gene

Paralogs for PPP1CA Gene

Pseudogenes.org Pseudogenes for PPP1CA Gene

genes like me logo Genes that share paralogs with PPP1CA: view

Variants for PPP1CA Gene

Sequence variations from dbSNP and Humsavar for PPP1CA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs367543169 untested 67,399,598(+) ATGGC(C/T)GCGAT reference, synonymous-codon
rs367543170 untested 67,400,699(+) TCGTA(A/G)AAACC reference, synonymous-codon
rs367543171 untested 67,400,821(+) GCCCC(G/T)GTCCA reference, synonymous-codon
rs1060380 -- 67,398,447(-) CCCCT(A/C)AGGCC downstream-variant-500B, utr-variant-3-prime
rs1064876 -- 67,398,289(-) GGCAA(C/T)GGCAG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP1CA Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv516453 CNV loss 19592680

Variation tolerance for PPP1CA Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1CA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1CA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1CA Gene

Disorders for PPP1CA Gene

Relevant External Links for PPP1CA

Human Genome Epidemiology (HuGE) Navigator
PPP1CA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1CA

No disorders were found for PPP1CA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1CA Gene

Publications for PPP1CA Gene

  1. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. (PMID: 26083323) Song H. … Zhang Z. (Autophagy 2015) 3 4 64
  2. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-I+ in rheumatoid arthritis. (PMID: 23396208) Nie H. … Zhang J.Z. (Nat. Med. 2013) 3 4 64
  3. Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. (PMID: 21712997) Schmutz I. … Albrecht U. (PLoS ONE 2011) 3 4 64
  4. Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. (PMID: 20305656) Ragusa M.J. … Peti W. (Nat. Struct. Mol. Biol. 2010) 3 4 64
  5. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PMID: 20424263) Li X. … Ann D.K. (Sci. Signal. 2010) 3 4 64

Products for PPP1CA Gene

Sources for PPP1CA Gene

Content
Loading form....