PPP1CA Gene
protein-coding GIFtS: 70
GCID: GC11M067165
|
|
protein phosphatase 1, catalytic subunit, alpha isozyme(Previous names: protein phosphatase 1, catalytic subunit, alpha isoform...)
(Previous symbol: PPP1A)
| |
Aliases
for PPP1CA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme1 2 | | Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform1 2 | | PPP1A1 2 3 5 | | EC 3.1.3.163 8 | | PP-1A1 2 3 | | Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit2 | | PP1A1 2 | | Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit2 | | PP1alpha1 2 | | |
Export aliases for PPP1CA gene to outside databasesPrevious GC identifers: GC11M069698 GC11M068861 GC11M067415 GC11M066941 GC11M066922 GC11M063494 |
Summaries
for PPP1CA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPP1CA:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is aserine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellularprocesses, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viraltranscription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human andmice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions asa suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymeswhich dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, andparticipates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved inregulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylatingsubstrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of thePTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressionduring the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosomenumber and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube andoptic fissure closure, and enteric neural crest cell (ENCCs) migration during development
 summary
for PPP1CA: Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.
Gene Wiki entry for PPP1CA
|
Genomic Views
for PPP1CA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPP1CA gene promoter:
HEN1 AhR p53 Sp1 Lmo2 ARP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP1CA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1CA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13PPP1CA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M067165: view genomic region
(about GC identifiers)
Start:
|
67,165,652 bp from pter |
End:
|
67,188,654 bp from pter |
Size:
|
23,003 bases |
Orientation:
|
minus strand |
|
Proteins
for PPP1CA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Size: 330 amino acids; 37512 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit
Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A,PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3Dand PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By similarity). Interacts with PPP1R9A andPPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PHACTR4; which acts as an activator ofPP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1.Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT.Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5.Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5. Interacts with PPP1R16B. Interacts with RPSA only in thepresence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CAor PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS.Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promotersite. Interacts with isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320.Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largelyexcluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targetingsubunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from thenucleus to nuclear speckles
6/8 PDB 3D structures from  and Proteopedia  for PPP1CA (see all 8):3E7A (3D)
3E7B (3D)
3EGG (3D)
3EGH (3D)
3HVQ (3D)
3N5U (3D)
Secondary accessions: B2R908 P08129 P20653 P22802 Q07161Alternative splicing: 2 isoforms: P62136-1 P62136-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PPP1CA: NX_P62136
Post-translational modifications:
Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62136
4/22 DME Specific Peptides for PPP1CA (P62136) (see all 22)
PPP1CA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001008709.1 NP_002699.1 NP_996756.1
ENSEMBL proteins: ENSP00000326031 ENSP00000365936 ENSP00000350974 ENSP00000431146 ENSP00000439568 ENSP00000438409 Reactome Protein details: P62136
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
PPP1CA for ontologies About GeneDecksing
PPP1CA Antibody Products:
Assay Products for PPP1CA: |
Protein
Domains /
Families
for PPP1CA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP1CA for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62136ProtoNet protein and cluster: P62136 UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily |
Function
for PPP1CA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PP1A_HUMAN, P62136Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymeswhich dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, andparticipates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved inregulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylatingsubstrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of thePTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressionduring the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosomenumber and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube andoptic fissure closure, and enteric neural crest cell (ENCCs) migration during developmentCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme regulation: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited bySalubrinal, a drug that protects cells from endoplasmic reticulum stress Genatlas biochemistry entry for PPP1CA:serine/threonine protein phosphatase 1,catalytic subunit,alpha,involved in mitotic exit
Enzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CA (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CA (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PPP1CA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CA |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004721 | phosphoprotein phosphatase activity |
-- | -- | | GO:0004722 | protein serine/threonine phosphatase activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0043021 | ribonucleoprotein complex binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
PPP1CA for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PPP1CA:
Animal Models:
1 MGI phenotypic allele  for Ppp1ca (no phenotypes)
PPP1CA for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPP1CA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | Opioid Signalling | | | 3 | Signaling by GPCR | | | 4 | Metabolism | | | 5 | Transcription CREB pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for PPP1CA (see all 7)
2 
Cell Signaling Technology (CST) Pathways for PPP1CA
1 Tocris Bioscience Pathway for PPP1CA
5/7  GeneGo (Thomson Reuters) Pathways for PPP1CA (see all 7)
4  BioSystems Pathways for PPP1CA
5/11 
Reactome Pathways for PPP1CA (see all 11)
1  PharmGKB Pathway for PPP1CA
5/6 
Kegg Pathways (Kegg details for PPP1CA) (see all 6):
PPP1CA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1CA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1086 Interacting proteins for PPP1CA (P621361, 2, 3 ENSP000003260314) via UniProtKB, MINT, STRING, and/or I2D (see all 1086)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SPRED1 | Q7Z6991, 2, 3, ENSP000002990844 | EBI-2623163,EBI-5235340 MINT-62190 I2D:
score=3 STRING: ENSP00000299084 | | PPP1R9B | Q96SB32, 3 | MINT-8290898 MINT-62199 MINT-8290911 MINT-8290954 I2D:
score=5 | | PPP1R8 | Q129722, 3, ENSP000003116774 | MINT-8292686 MINT-8338344 MINT-62188 I2D:
score=4 STRING: ENSP00000311677 | | SF3B1 | O755332, 3, ENSP000003353214 | MINT-8292725 MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000335321 | | SGOL2 | Q562F62, 3 | MINT-8212643 MINT-8212619 MINT-8212589 MINT-8210383 I2D:
score=1 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005977 | glycogen metabolic process |
IEA | -- | | GO:0005979 | regulation of glycogen biosynthetic process |
IEA | -- | | GO:0005981 | regulation of glycogen catabolic process |
IEA | -- | | GO:0006470 | protein dephosphorylation |
IEA | -- | | GO:0006629 | lipid metabolic process |
TAS | -- |
PPP1CA for ontologies About GeneDecksing
|
Drugs & Compounds
for PPP1CA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for PPP1CA available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Cantharidin | Protein phosphatase 1 and 2A inhibitor | [56-25-7] | | Okadaic acid | Protein phosphatase 1 and 2A inhibitor | [78111-17-8] | | Calyculin A | Protein phosphatase 1 and 2A inhibitor | [101932-71-2] | | Tautomycetin | Selective PP1 inhibitor | [119757-73-2] |
4 HMDB Compounds for PPP1CA About this table
1 DrugBank Compound for PPP1CA About this table
Search CenterWatch for drugs/clinical trials and news about PPP1CA / PP1A
|
Transcripts
for PPP1CA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPP1CA gene (3 alternative transcripts): NM_001008709.1 NM_002708.3 NM_206873.1 Unigene Cluster for PPP1CA: Protein phosphatase 1, catalytic subunit, alpha isozyme Hs.183994 [show with all ESTs]Unigene Representative Sequence: AK09831111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312989(uc001okx.1) ENST00000532446 ENST00000526510 ENST00000376745(uc001oku.1 uc001okv.1 uc001okw.1)
ENST00000358239 ENST00000532279 ENST00000527663 ENST00000537694 ENST00000529724
ENST00000546202 ENST00000542876
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CA (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CA (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PPP1CA (NM_002708) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP1CA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CA |
Additional cDNA sequence: AK098311.1 AK127616.1 AK313586.1 BC001888.1 BC004482.2 BC008010.1 BT006629.1 J04759.1 M63960.1 S57501.1 X70848.1 24/28 DOTS entries (see all 28): DT.92465318 DT.100884968 DT.100884945 DT.100760796 DT.100884978 DT.100884941 DT.450687 DT.97855870 DT.100884952 DT.80100500 DT.120703507 DT.100884967 DT.97796802 DT.100884977 DT.120703503 DT.92465301 DT.100884942 DT.97804697 DT.100884979 DT.100808596 DT.100884983 DT.120703613 DT.100733566 DT.120703618 24/931 AceView cDNA sequences (see all 931): BQ898974 BQ682580 BU527376 BM985077 R54872 BE783007 BG163325 BP379073 AA478424 BU188671 BE278068 BI869908 AW575931 BM907357 BG774903 BQ643862 CN478505 BU156756 BQ421174 BP338683 BE908299 CB106912 CR607708 BM563294
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CA (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PPP1CA
|
Expression
for PPP1CA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPP1CA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCTTGGT
About this image
See PPP1CA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP1CA
SOURCE GeneReport for Unigene cluster: Hs.183994
SABiosciences Expression via Pathway-Focused PCR Arrays including PPP1CA:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1CA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP1CA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1CA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1CA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CA |
Orthologs
for PPP1CA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPP1CA gene from 8/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PPP1CC6 |
-- |
90(a) |
1 ↔ 1 |
GL343423.1(395427-410592) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ppp1ca-prov2 |
Protein phosphatase type 1 alpha, catalytic subunit |
84(n) |
|
BC041730.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ppp1caa1 |
protein phosphatase 1, catalytic subunit, alpha isoform more |
78.25(n)
91.46(a) |
|
407980 NM_214811.2 NP_999976.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pp1-87B3
Pp1alpha-96A1 |
adult locomotory behavior protein
serine/threonine more3
Protein phosphatase 1alpha at 96A1 |
93(a)
(best of 10)3
76.23(n)1
88.58(a)1 |
|
429221 NM_079760.21 NP_524484.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
C25A6.13
gsp-21 |
Protein GSP-21 |
55(a)
(best of 28)3
74.67(n)1
91.08(a)1 |
|
V(5408340-5409883)3
35648071 NM_001027445.31 NP_001022616.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
PPQ1(YPL179W)4
GLC71 |
Putative protein serine/threonine phosphatase; null more4
Glc7p1 |
65.89(n)1
85.67(a)1 |
|
16(208157-209806)4
8568701 NP_011059.31 8559234
NP_015146.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TOPP21 |
serine/threonine-protein phosphatase PP1 isozyme 2 |
68.37(n)
80.89(a) |
|
836034 NM_001037026.1 NP_001032103.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.63592 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
79.4(n) |
|
AK121378.1 |
ENSEMBL Gene Tree for PPP1CA (if available)
TreeFam Gene Tree for PPP1CA (if available) |
Paralogs
for PPP1CA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPP1CA gene
- PPP1CB2 PPP1CC2
11 SIMAP similar genes for PPP1CA using alignment to 8 protein entries: PP1A_HUMAN (see all proteins):PPP1CB PPP1CC PPP2CA PPP2CB PPP6C PPP4C
PPP3CB PPP3CA PPP5C PPP3CC PPEF1
PPP1CA for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PPP1CA
PGOHUM00000243303
|
Genomic Variants
for PPP1CA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPP1CA (67165652 - 67188654 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PPP1CA
1 CNV: 48873 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1CA |
|
Disorders
/ Diseases
for PPP1CA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPP1CA for disorders About GeneDecksing
OMIM gene information: 176875
OMIM disorders: --
16  diseases for PPP1CA: About MalaCardssevere acute respiratory syndrome metastasis efficiency oral squamous cell carcinoma squamous cell carcinoma
herpes simplex retinoblastoma prostate cancer glioblastoma
carcinoma retinitis prostatitis immunodeficiency
pancreatitis malaria neuronitis ischemia
Human Genome Epidemiology (HuGE) Navigator: PPP1CA (1 document)
Export disorders for PPP1CA gene to outside databases
|
Publications
for PPP1CA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPP1CA gene, integrated from 9 sources (see all 159):
(articles sorted by number of sources associating them with PPP1CA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H....Skalnik D.G. (2010)
- SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PubMed id 20424263)1, 2 Li X....Ann D.K. (2010)
- Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors. (PubMed id 18992256)1, 2 Kelker M.S....Peti W. (2009)
- GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461)1, 2 Fujiki R.... Kato S. (2009)
- NOM1 targets protein phosphatase I to the nucleolus. (PubMed id 17965019)1, 2 Gunawardena S.R.... Conklin K.F. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Protein phosphatase 1 -- targeted in many directions. (PubMed id 11839776)1, 2 Cohen P.T.W. (2002)
- Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PubMed id 12226088)1, 2 Ceulemans H....Bollen M. (2002)
- Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PubMed id 11564868)1, 2 Connor J.H.... Shenolikar S. (2001)
|
External Searches for PPP1CA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPP1CA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPP1CA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPP1CA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PPP1CA gene:
Search GeneIP for patents involving PPP1CA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPP1CA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for PPP1CA | | OriGene shRNA RFP for PPP1CA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1CA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1CA | | | OriGene Protein Over-expression Lysate for PPP1CA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPP1CA | | OriGene 3'-UTR Clone for PPP1CA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1CA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPP1CA | | OriGene Custom Protein Services for PPP1CA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP1CA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1CA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1CA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1CA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1CA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1CA |
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| | Antibodies & Assays for PPP1CA |
| | | |  |  |  |  | | | | | | Recombinant Protein for PPP1CA |
|
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1CA |
|  |  |  | | | | ThermoFisher Antibodies for PPP1CA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1CA |
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