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Aliases for PPP1CA Gene

Aliases for PPP1CA Gene

  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme 2 3
  • PPP1A 3 4 6
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform 2 3
  • EC 3.1.3.16 4 64
  • PP-1A 3 4
  • Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit 3
  • Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit 3
  • PP1alpha 3
  • PP1A 3

External Ids for PPP1CA Gene

Previous Symbols for PPP1CA Gene

  • PPP1A

Summaries for PPP1CA Gene

Entrez Gene Summary for PPP1CA Gene

  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1CA Gene

PPP1CA (Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme) is a Protein Coding gene. Diseases associated with PPP1CA include hiv-1. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include protein serine/threonine phosphatase activity and ribonucleoprotein complex binding. An important paralog of this gene is PPP1CC.

UniProtKB/Swiss-Prot for PPP1CA Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CA Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP1CA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1CA Gene

Genomics for PPP1CA Gene

Genomic Location for PPP1CA Gene

Start:
67,398,181 bp from pter
End:
67,421,183 bp from pter
Size:
23,003 bases
Orientation:
Minus strand

Genomic View for PPP1CA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CA Gene

Regulatory Elements for PPP1CA Gene

Proteins for PPP1CA Gene

  • Protein details for PPP1CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62136-PP1A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Protein Accession:
    P62136
    Secondary Accessions:
    • A6NNR3
    • B2R908
    • P08129
    • P20653
    • P22802
    • Q07161

    Protein attributes for PPP1CA Gene

    Size:
    330 amino acids
    Molecular mass:
    37512 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity)Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PHACTR4; which acts as an activator of PP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on Ser-824 and forms a complex at the p21 promoter site. Interacts with isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320. Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with FOXP3.

    Three dimensional structures from OCA and Proteopedia for PPP1CA Gene

    Alternative splice isoforms for PPP1CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CA Gene

Proteomics data for PPP1CA Gene at MOPED

Post-translational modifications for PPP1CA Gene

  • Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6, Lys26, Lys98, Lys113, Lys141, Lys147, Lys150, Lys168, Lys238, Lys260, and Lys305

Other Protein References for PPP1CA Gene

Domains for PPP1CA Gene

Gene Families for PPP1CA Gene

HGNC:
  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

Protein Domains for PPP1CA Gene

UniProtKB/Swiss-Prot:

PP1A_HUMAN
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.:
    • P62136
genes like me logo Genes that share domains with PPP1CA: view

Function for PPP1CA Gene

Molecular function for PPP1CA Gene

GENATLAS Biochemistry: serine/threonine protein phosphatase 1,catalytic subunit,alpha,involved in mitotic exit
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
UniProtKB/Swiss-Prot Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot Induction: Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Enzyme Numbers (IUBMB) for PPP1CA Gene

Gene Ontology (GO) - Molecular Function for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0005515 protein binding IPI 10807923
GO:0016787 hydrolase activity --
GO:0016791 phosphatase activity ISS --
genes like me logo Genes that share ontologies with PPP1CA: view

Phenotypes for PPP1CA Gene

genes like me logo Genes that share phenotypes with PPP1CA: view

miRNA for PPP1CA Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1CA Gene

Localization for PPP1CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CA Gene

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1CA Gene COMPARTMENTS Subcellular localization image for PPP1CA gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0005634 nucleus IDA 11739654
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PPP1CA: view

Pathways for PPP1CA Gene

genes like me logo Genes that share pathways with PPP1CA: view

Gene Ontology (GO) - Biological Process for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0005981 regulation of glycogen catabolic process IEA --
GO:0006470 protein dephosphorylation ISS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PPP1CA: view

Compounds for PPP1CA Gene

(5) Tocris Compounds for PPP1CA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(4) HMDB Compounds for PPP1CA Gene

Compound Synonyms Cas Number PubMed IDs
Glycogen
  • Animal starch
9005-79-2
Iron
  • Armco iron
7439-89-6
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2

(1) Drugbank Compounds for PPP1CA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
target
genes like me logo Genes that share compounds with PPP1CA: view

Transcripts for PPP1CA Gene

Unigene Clusters for PPP1CA Gene

Protein phosphatase 1, catalytic subunit, alpha isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -
SP8:
SP9: - - - -
SP10:

Relevant External Links for PPP1CA Gene

GeneLoc Exon Structure for
PPP1CA
ECgene alternative splicing isoforms for
PPP1CA

Expression for PPP1CA Gene

mRNA expression in normal human tissues for PPP1CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1CA Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1CA Gene

SOURCE GeneReport for Unigene cluster for PPP1CA Gene Hs.183994

genes like me logo Genes that share expressions with PPP1CA: view

Orthologs for PPP1CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1CA 36
  • 99.7 (n)
  • 100 (a)
PPP1CA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1CA 36
  • 93.03 (n)
  • 100 (a)
PPP1CA 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1CA 36
  • 92.93 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Ppp1ca 36
  • 90.1 (n)
  • 99.7 (a)
Ppp1ca 16
Ppp1ca 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1CA 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CA 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1ca 36
  • 90.3 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia PPP1CA 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ppp1ca-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6652 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9837 36
zebrafish
(Danio rerio)
Actinopterygii ppp1caa 36
  • 78.25 (n)
  • 91.46 (a)
ppp1caa 37
  • 90 (a)
ManyToMany
ppp1cab 37
  • 89 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Pp1-13C 37
  • 91 (a)
ManyToMany
Pp1-87B 37
  • 93 (a)
ManyToMany
Pp1alpha-96A 37
  • 88 (a)
ManyToMany
Pp1alpha-96A 38
  • 88 (a)
PpD5 38
  • 64 (a)
PpN58A 38
  • 63 (a)
PpY-55A 38
  • 64 (a)
PpD6 38
  • 60 (a)
Pp1-87B 38
  • 93 (a)
Pp1-Y2 38
  • 74 (a)
Pp1rY1 38
  • 59 (a)
flw 38
  • 84 (a)
Pp1-13C 38
  • 91 (a)
worm
(Caenorhabditis elegans)
Secernentea gsp-2 36
  • 74.67 (n)
  • 91.08 (a)
Y71G12B.30 37
  • 46 (a)
ManyToMany
F52H3.6 38
  • 54 (a)
F42G8.8 38
  • 36 (a)
C23G10.1a 38
  • 46 (a)
F49E11.7 38
  • 38 (a)
T03F1.5 38
  • 53 (a)
C34D4.2 38
  • 52 (a)
F58G1.3 38
  • 43 (a)
R08A2.2 38
  • 38 (a)
C24H11.2 38
  • 48 (a)
W09C3.6 38
  • 54 (a)
Y69E1A.4 38
  • 41 (a)
C47A4.3 38
  • 52 (a)
C06A1.3 38
  • 47 (a)
C23G10.1b 38
  • 46 (a)
C27B7.6 38
  • 41 (a)
Y40H4A.2 38
  • 38 (a)
F25B3.4 38
  • 55 (a)
C25A6.1 38
  • 55 (a)
W03D8.2 38
  • 47 (a)
F22D6.9 38
  • 40 (a)
C09H5.7 38
  • 48 (a)
ZC477.2 38
  • 33 (a)
C30A5.4 38
  • 32 (a)
F23B12.1 38
  • 53 (a)
R13A5.11 38
  • 42 (a)
ZK354.9 38
  • 53 (a)
T25B9.2 38
  • 41 (a)
C24H11.1 38
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR166C 36
  • 75.27 (n)
  • 83.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 36
  • 65.89 (n)
  • 85.67 (a)
GLC7 37
  • 84 (a)
OneToMany
PPQ1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12496g 36
  • 65.77 (n)
  • 84.95 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TOPP2 36
  • 68.37 (n)
  • 80.89 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1740 36
rice
(Oryza sativa)
Liliopsida Os.6359 36
Os02g0820000 36
  • 69.82 (n)
  • 79.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14255 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00043 36
  • 75.03 (n)
  • 86.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dis2 36
  • 68.35 (n)
  • 84.81 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11530 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7187 37
  • 92 (a)
OneToMany
Species with no ortholog for PPP1CA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP1CA Gene

ENSEMBL:
Gene Tree for PPP1CA (if available)
TreeFam:
Gene Tree for PPP1CA (if available)

Paralogs for PPP1CA Gene

Paralogs for PPP1CA Gene

Selected SIMAP similar genes for PPP1CA Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PPP1CA Gene

genes like me logo Genes that share paralogs with PPP1CA: view

Variants for PPP1CA Gene

Sequence variations from dbSNP and Humsavar for PPP1CA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2286620 -- 67,399,513(+) GGTGC(C/T)GAGGG intron-variant
rs2286621 -- 67,399,673(+) GCCCA(C/G)GGGGA intron-variant
rs4930425 -- 67,400,055(+) tcgct(G/T)gaacc intron-variant
rs11542939 -- 67,400,837(-) TTTCT(A/G)GGGGA synonymous-codon, reference
rs11827571 -- 67,399,174(+) GGGCC(A/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1CA Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv516453 CNV Loss 19592680
dgv1195n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294

Relevant External Links for PPP1CA Gene

HapMap Linkage Disequilibrium report
PPP1CA

Disorders for PPP1CA Gene

(1) MalaCards Diseases for PPP1CA Gene

Search for PPP1CA Gene in MalaCards »

Relevant External Links for PPP1CA

Human Genome Epidemiology (HuGE) Navigator
PPP1CA
genes like me logo Genes that share disorders with PPP1CA: view

No data available for UniProtKB/Swiss-Prot for PPP1CA Gene

Publications for PPP1CA Gene

  1. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. (PMID: 8384581) Durfee T. … Elledge S.J. (Genes Dev. 1993) 3 4
  2. Cloning and characterization of a human protein phosphatase 1- encoding cDNA. (PMID: 8392016) Song Q. … Lavin M.F. (Gene 1993) 3 4
  3. Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. (PMID: 2161401) Barker H.M. … Cohen P.T.W. (Genomics 1990) 3 4
  4. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. (PMID: 11564868) Connor J.H. … Shenolikar S. (Mol. Cell. Biol. 2001) 3 4
  5. Protein phosphatase 1 -- targeted in many directions. (PMID: 11839776) Cohen P.T.W. (J. Cell Sci. 2002) 3 4

Products for PPP1CA Gene

Sources for PPP1CA Gene

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