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PPME1 Gene

protein-coding   GIFtS: 53
GCID: GC11P073882

Protein Phosphatase Methylesterase 1

  See PPME1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase Methylesterase 11 2
PME-12 3
Protein Phosphatase Methylesterase-12
EC 3.1.1.893
PME13
EC 3.1.18

External Ids:    HGNC: 301781   Entrez Gene: 514002   Ensembl: ENSG000002145177   OMIM: 6111175   UniProtKB: Q9Y5703   

Export aliases for PPME1 gene to outside databases

Previous GC identifers: GC11P073560 GC11P070177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPME1 Gene:
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the
protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory
proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Oct 2012)

GeneCards Summary for PPME1 Gene:
PPME1 (protein phosphatase methylesterase 1) is a protein-coding gene. Diseases associated with PPME1 include unverricht-lundborg syndrome, and malignant glioma. GO annotations related to this gene include protein phosphatase inhibitor activity and protein kinase binding.

UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570
Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and
PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPME1 gene promoter:
         SREBP-1c   E2F-2   Gfi-1   SREBP-1b   E2F-1   POU2F1   SREBP-1a   E2F   POU2F1a   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPME1 promoter sequence
   Search Chromatin IP Primers for PPME1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

PPME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPME1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073882:  view genomic region     (about GC identifiers)

Start:
73,882,144 bp from pter      End:
73,965,748 bp from pter
Size:
83,605 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570 (See protein sequence)
Recommended Name: Protein phosphatase methylesterase 1  
Size: 386 amino acids; 42315 Da
Subunit: Binds PPP2CA and PPP2CB
Sequence caution: Sequence=AAG22477.1; Type=Erroneous translation; Note=Wrong choice of CDS;
2 PDB 3D structures from and Proteopedia for PPME1:
3C5V (3D)        3C5W (3D)    
Secondary accessions: B3KMU6 B5MEE7 Q8WYG8 Q9NVT5 Q9UI18
Alternative splicing: 3 isoforms:  Q9Y570-1   Q9Y570-2   Q9Y570-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPME1: NX_Q9Y570

Explore proteomics data for PPME1 at MOPED

Post-translational modifications: 

  • Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein
    phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PPME1 (Q9Y570)
     DLTIGQMQGKFQ  MLIGHSMGGAIAVHTA 


    See PPME1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258522.1  NP_057231.1  

    ENSEMBL proteins: 
     ENSP00000329867   ENSP00000381461   ENSP00000438632   ENSP00000441498  

    PPME1 Human Recombinant Protein Products:

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    Novus Biologicals PPME1 Proteins
    Novus Biologicals PPME1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPME1
    Cloud-Clone Corp. Proteins for PPME1

     
    Search eBioscience for Proteins for PPME1 

    PPME1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPME1
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    LSBio Antibodies in human, mouse, rat for PPME1

    PPME1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPME1
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    Search eBioscience for ELISAs for PPME1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016812 PPase_methylesterase_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y570

    ProtoNet protein and cluster: Q9Y570

    1 Blocks protein domain: IPB008262 Lipase

    UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570
    Similarity: Belongs to the AB hydrolase superfamily


    Find genes that share domains with PPME1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPME1_HUMAN, Q9Y570
    Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and
    PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme
    Catalytic activity: [Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine +
    methanol

         Enzyme Numbers (IUBMB): EC 3.1.1.891 EC 3.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity TAS10318862
    GO:0008601protein phosphatase type 2A regulator activity TAS10318862
    GO:0019901protein kinase binding ----
    GO:0019903protein phosphatase binding IDA10318862
    GO:0051721protein phosphatase 2A binding IDA10318862
         
    Find genes that share ontologies with PPME1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPME1:
     Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppme1):
     behavior/neurological  homeostasis/metabolism  mortality/aging  respiratory system 

    Find genes that share phenotypes with PPME1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppme1tm1Crv for PPME1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPME1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPME1

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPME1

    miRNA
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    Block miRNA regulation of human, mouse, rat PPME1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPME1 (see all 36):
    hsa-miR-330-5p hsa-miR-128 hsa-miR-578 hsa-miR-488 hsa-miR-764 hsa-miR-218 hsa-miR-326 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPPME1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPME1
    Predesigned siRNA for gene silencing in human, mouse, rat PPME1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PPME1 (see all 7)
    OriGene ORF clones in mouse, rat for PPME1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPME1 (NM_016147)
    Sino Biological Human cDNA Clone for PPME1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPME1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPME1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPME1
    Interactions:

        Search GeneGlobe Interaction Network for PPME1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PPME1 (Q9Y5703 ENSP000003814614) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627143, ENSP000002211384I2D: score=7 STRING: ENSP00000221138
    PPP2R1AP301533, ENSP000003248044I2D: score=4 STRING: ENSP00000324804
    NFKB1P198383, ENSP000002265744I2D: score=1 STRING: ENSP00000226574
    PPP2CAP677753, ENSP000004184474I2D: score=2 STRING: ENSP00000418447
    PPP4CP605103, ENSP000002793874I2D: score=1 STRING: ENSP00000279387
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006482protein demethylation IDA10318862
    GO:0043086negative regulation of catalytic activity TAS10318862
    GO:0050790regulation of catalytic activity TAS10318862

    Find genes that share ontologies with PPME1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPME1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPME1 gene (2 alternative transcripts): 
    NM_001271593.1  NM_016147.2  

    Unigene Cluster for PPME1:

    Protein phosphatase methylesterase 1
    Hs.503251  [show with all ESTs]
    Unigene Representative Sequence: AK095005
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328257(uc001ouw.3) ENST00000542710 ENST00000398427(uc009yty.3)
    ENST00000544401 ENST00000543525(uc001oux.3) ENST00000535205 ENST00000541340
    ENST00000538501 ENST00000539021
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPME1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPME1 (see all 36):
    hsa-miR-330-5p hsa-miR-128 hsa-miR-578 hsa-miR-488 hsa-miR-764 hsa-miR-218 hsa-miR-326 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPPME1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPME1
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    OriGene ORF clones in mouse, rat for PPME1
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    GenScript: all cDNA clones in your preferred vector: PPME1 (NM_016147)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPME1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPME1
    OriGene qSTAR qPCR primer pairs in human, mouse for PPME1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPME1
      QuantiTect SYBR Green Assays in human, mouse, rat PPME1
      QuantiFast Probe-based Assays in human, mouse, rat PPME1

    Additional mRNA sequence: 

    AF111853.1 AF157028.1 AK001381.1 AK022725.1 AK025414.1 AK025879.1 AK095005.1 AK123288.1 
    AK225647.1 BC003046.1 BC050705.2 BX537528.1 

    18 DOTS entries:

    DT.454947  DT.97790933  DT.99934073  DT.100812255  DT.95133930  DT.100812262  DT.92011766  DT.95108338 
    DT.100812254  DT.100646458  DT.120749415  DT.120749471  DT.120749523  DT.40130359  DT.91758002  DT.92023305 
    DT.95108336  DT.40263521 

    Selected AceView cDNA sequences (see all 400):

    BP341282 AW438816 BM753819 BP364815 BE046327 AK001381 BM720197 BM766045 
    CR609996 BE889749 BQ049717 AI125166 AU141112 AL528361 AI128295 AL040537 
    BX105947 BE793818 BP365028 BM545255 BM741832 AI554829 BX417064 BM666890 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCGGAGTC
    PPME1 Expression
    About this image

    PPME1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPME1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503251
        Custom PCR Arrays for PPME1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPME1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPME1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppme11 , 5 protein phosphatase methylesterase 11, 5 91.71(n)1
    97.93(a)1
      7 (54.35 cM)5
    725901  NM_028292.21  NP_082568.11 
     1003267375 
    chicken
    (Gallus gallus)
    Aves PPME11 protein phosphatase methylesterase 1 81.74(n)
    91.85(a)
      419058  NM_001030834.1  NP_001026005.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPME16
    protein phosphatase methylesterase 1
    84(a)
    1 ↔ 1
    AAWZ02038622(1169-10902)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppme11 protein phosphatase methylesterase 1 76.04(n)
    86.46(a)
      100495664  XM_002942520.2  XP_002942566.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk72d032 wufk72d03 75.19(n)   335124  BC046016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50681 CG5068 54.05(n)
    51.08(a)
      39032  NM_140020.3  NP_648277.3 
    worm
    (Caenorhabditis elegans)
    Secernentea B0464.91 B0464.9 55.56(n)
    51.49(a)
      181999  NM_066683.3  NP_499084.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPE1(YHR075C)4
    PPE11
    Protein with carboxyl methyl esterase activity that more4
    PPE11
    46.01(n)1
    35.78(a)1
      8(249641-248439)4
    8564741, 4  NP_011942.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G100501 AT4G10050 54.17(n)
    51.01(a)
      826596  NM_117073.3  NP_567350.1 
    rice
    (Oryza sativa)
    Liliopsida Os.187612 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.41(n)    AK105357.1 


    ENSEMBL Gene Tree for PPME1 (if available)
    TreeFam Gene Tree for PPME1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPME1 gene
    1 SIMAP similar gene for PPME1 using alignment to 3 protein entries:     PPME1_HUMAN (see all proteins):
    MGLL

    Find genes that share paralogs with PPME1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPME1 (see all 1445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79255001,2
    C--73884402(+) AATCAG/TATTTT 2 -- int10--------
    rs800865661,2
    C,F--73884403(+) ATCAGA/CTTTTT 2 -- int11Minor allele frequency- C:0.03NA 120
    rs1929614571,2
    --73884455(+) CTTCTC/TATCTT 2 -- int10--------
    rs1140377201,2
    F--73884461(+) ATCTTG/TGAGAA 2 -- int11Minor allele frequency- T:0.04WA 118
    rs1847794951,2
    --73884618(+) GTCTCA/GCTCTG 2 -- int10--------
    rs1896456811,2
    --73884709(+) AGCCTC/TCCAAG 2 -- int10--------
    rs1925250141,2
    --73884733(+) AGGCAC/TGCACC 2 -- int10--------
    rs1396206381,2
    C--73884783(+) GATTTC/GGCCAT 2 -- int10--------
    rs1837655281,2
    --73884900(+) TTTTTA/TAAAAG 2 -- int10--------
    rs1884413091,2
    --73884970(+) AAGGCC/TTTTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PPME1 (73882144 - 73965748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PPME1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744775CNV Deletion23290073
    esv269607CNV Insertion20981092
    nsv522994CNV Loss19592680
    esv34979CNV Gain17911159
    nsv825994CNV Gain20364138
    dgv397e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPME1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611117    OMIM disorders: --

    2 diseases for PPME1:    
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    unverricht-lundborg syndrome    malignant glioma

    1 disease from the University of Copenhagen DISEASES database for PPME1:
    Unverricht-Lundborg syndrome

    Find genes that share disorders with PPME1           About GenesLikeMe

    Genetic Association Database (GAD): PPME1

    Export disorders for PPME1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPME1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PPME1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PubMed id 10318862)1, 2, 3, 9 Ogris E....Pallas D.C. (J. Biol. Chem. 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. (PubMed id 19293187)1, 9 Puustinen P....Westermarck J. (Cancer Res. 2009)
    6. Spatial control of protein phosphatase 2A (de)methylation. (PubMed id 17803990)1, 9 Longin S....Janssens V. (Exp. Cell Res. 2008)
    7. The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity. (PubMed id 22443683)1 Sents W....Janssens V. (FEBS J. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51400 HGNC: 30178 AceView: PME-1 Ensembl:ENSG00000214517 euGenes: HUgn51400
    ECgene: PPME1 H-InvDB: PPME1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPME1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPME1 gene:
    Search GeneIP for patents involving PPME1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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