Aliases for PPME1 Gene
External Ids for PPME1 Gene
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
GeneCards Summary for PPME1 Gene
PPME1 (Protein Phosphatase Methylesterase 1) is a Protein Coding gene. Diseases associated with PPME1 include malignant glioma and unverricht-lundborg syndrome. GO annotations related to this gene include protein kinase binding and protein phosphatase inhibitor activity.
UniProtKB/Swiss-Prot for PPME1 Gene
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.