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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPME1 Gene

protein-coding   GIFtS: 52
GCID: GC11P073882

protein phosphatase methylesterase 1
 Explore 6 diseases affiliated with
PPME1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPME1    

Aliases
for PPME1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase Methylesterase 11 2
PME-11 2 3
Protein Phosphatase Methylesterase-12
EC 3.1.1.893
PME13
EC 3.1.18

External Ids:    HGNC: 301781   Entrez Gene: 514002   Ensembl: ENSG000002145177   OMIM: 6111175   UniProtKB: Q9Y5703   

Export aliases for PPME1 gene to outside databases

Previous GC identifers: GC11P073560 GC11P070177


Summaries
for PPME1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPME1:
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the
protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory
proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570
Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA.
Binding to PPP2CA displaces the manganese ion and inactivates the enzyme




Genomic Views
for PPME1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPME1 gene promoter:
         SREBP-1c   E2F-2   Gfi-1   SREBP-1b   E2F-1   POU2F1   SREBP-1a   E2F   POU2F1a   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPME1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPME1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

PPME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPME1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073882:  view genomic region     (about GC identifiers)

Start:
 73,882,144 bp from pter      End:
 73,965,748 bp from pter
Size:
 83,605 bases      Orientation:
 plus strand

Proteins
for PPME1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570 (See protein sequence)
Recommended Name: Protein phosphatase methylesterase 1  
Size: 386 amino acids; 42315 Da
Subunit: Binds PPP2CA and PPP2CB
Sequence caution: Sequence=AAG22477.1; Type=Erroneous translation; Note=Wrong choice of CDS;
2 PDB 3D structures from and Proteopedia for PPME1:
3C5V (3D)        3C5W (3D)    
Secondary accessions: B3KMU6 B5MEE7 Q8WYG8 Q9NVT5 Q9UI18
Alternative splicing: 3 isoforms:  Q9Y570-1   Q9Y570-2   Q9Y570-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPME1: NX_Q9Y570

Post-translational modifications:

  • Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein
    • phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 (By
    similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y570

    • 2 DME Specific Peptides for PPME1 (Q9Y570)
     DLTIGQMQGKFQ  MLIGHSMGGAIAVHTA 

    PPME1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258522.1  NP_057231.1  

    ENSEMBL proteins: 
     ENSP00000329867   ENSP00000381461   ENSP00000438632   ENSP00000441498  

    Human Recombinant Protein Products: 
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    Novus Biologicals PPME1 Proteins
    Novus Biologicals PPME1 Lysates
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    Uscn Proteins for PPME1


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    Assay Products for PPME1: 
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    Uscn ELISAs and CLIAs for PPME1

    Protein Domains /
    Families
    for PPME1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPME1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR016812 PPase_methylesterase_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y570

    ProtoNet protein and cluster: Q9Y570

    1 Blocks protein family: IPB008262 Lipase

    UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570
    Similarity: Belongs to the AB hydrolase superfamily


    Function
    for PPME1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPME1_HUMAN, Q9Y570
    Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA.
    Binding to PPP2CA displaces the manganese ion and inactivates the enzyme
    Catalytic activity: [Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol

    Enzyme Numbers (IUBMB): EC 3.1.1.891 EC 3.1.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPME1
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PPME1 (see all 36):
    hsa-miR-330-5p hsa-miR-128 hsa-miR-578 hsa-miR-488 hsa-miR-764 hsa-miR-218 hsa-miR-326 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: PPME1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPME1 (see all 4)
    OriGene shRNA RFP: PPME1
    OriGene siRNA: PPME1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPME1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPME1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPME1 (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPME1 

    Cell Line
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    Search LifeMap BioReagents cell lines for PPME1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPME1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091carboxylesterase activity IEA--
    GO:0004864protein phosphatase inhibitor activity TAS10318862
    GO:0008601protein phosphatase type 2A regulator activity TAS10318862
    GO:0019901protein kinase binding IEA--
    GO:0019903protein phosphatase binding IDA10318862


    PPME1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PPME1:
     Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Ppme1tm1Crv for PPME1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ppme1):
     behavior/neurological  homeostasis/metabolism  mortality/aging  respiratory system 

    PPME1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPME1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPME1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/29 Interacting proteins for PPME1 (Q9Y5703 ENSP000003814614) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627143, ENSP000002211384I2D: score=7 STRING: ENSP00000221138
    PPP2R1AP301533, ENSP000003248044I2D: score=4 STRING: ENSP00000324804
    NFKB1P198383, ENSP000002265744I2D: score=1 STRING: ENSP00000226574
    PPP2CAP677753, ENSP000004184474I2D: score=2 STRING: ENSP00000418447
    PPP4CP605103, ENSP000002793874I2D: score=1 STRING: ENSP00000279387
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006482protein demethylation IDA10318862


    PPME1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPME1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPME1
    Search CenterWatch for drugs/clinical trials and news about PPME1 

    Transcripts
    for PPME1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPME1 gene (2 alternative transcripts): 
    NM_001271593.1  NM_016147.2  

    Unigene Cluster for PPME1:

    Protein phosphatase methylesterase 1
    Hs.503251  [show with all ESTs]
    Unigene Representative Sequence: AK095005
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328257(uc001ouw.3) ENST00000542710 ENST00000398427(uc009yty.3)
    ENST00000544401 ENST00000543525(uc001oux.3) ENST00000535205 ENST00000541340
    ENST00000538501 ENST00000539021

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPME1
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PPME1 (see all 36):
    hsa-miR-330-5p hsa-miR-128 hsa-miR-578 hsa-miR-488 hsa-miR-764 hsa-miR-218 hsa-miR-326 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: PPME1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPME1 (see all 4)
    OriGene shRNA RFP: PPME1
    OriGene siRNA: PPME1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPME1
    Clone
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    GenScript: all cDNA clones in your preferred vector: PPME1 (NM_016147)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPME1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPME1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPME1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPME1

    Additional cDNA sequence: 

    AF111853.1 AF157028.1 AK001381.1 AK022725.1 AK025414.1 AK025879.1 AK095005.1 AK123288.1 
    AK225647.1 BC003046.1 BC050705.2 BX537528.1 

    18 DOTS entries:

    DT.454947  DT.97790933  DT.99934073  DT.100812255  DT.95133930  DT.100812262  DT.92011766  DT.95108338 
    DT.100812254  DT.100646458  DT.120749415  DT.120749471  DT.120749523  DT.40130359  DT.91758002  DT.92023305 
    DT.95108336  DT.40263521 

    24/400 AceView cDNA sequences (see all 400):

    BQ055976 CB158130 BM876341 BM702998 AA626357 BQ070452 BE905650 BM748185 
    BP363536 AF146798 BM710899 BP365028 BI771319 AU280023 BM773399 CN481319 
    CA488554 AL040537 BX105947 AK025879 NM_016147 BP364815 BE793818 BE264658 

    GeneLoc Exon Structure


    Expression
    for PPME1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCCGGAGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPME1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPME1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPME1

    SOURCE GeneReport for Unigene cluster: Hs.503251
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    In Situ
    Assay Products:     
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    Orthologs
    for PPME1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPME1 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppme11 , 5 protein phosphatase methylesterase 11, 5 91.71(n)1
    97.93(a)1    		   7 (54.35 cM)5
    725901  NM_028292.21  NP_082568.11 
     1003267375 
    chicken
    (Gallus gallus)    		 Aves PPME11 protein phosphatase methylesterase 1 82.02(n)
    91.85(a)    		   419058  NM_001030834.1  NP_001026005.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPME16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 AAWZ02038622(1539-10840)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk72d032 wufk72d03 75.19(n)   335124  BC046016.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG50681 CG5068 53.9(n)
    51.86(a)    		   39032  NM_140020.2  NP_648277.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0464.91 Protein B0464.9 55.56(n)
    51.49(a)    		   181999  NM_066683.2  NP_499084.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PPE1(YHR075C)4
    PPE11    		 Protein with carboxyl methyl esterase activity that more4
    Ppe1p1    		 47.4(n)1
    35.46(a)1    		   8(249641-248439)4
    8564741, 4  NP_011942.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G100501 protein phosphatase methylesterase 1 54.66(n)
    51.75(a)    		   826596  NM_117073.3  NP_567350.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.187612 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.41(n)    AK105357.1 


    ENSEMBL Gene Tree for PPME1 (if available)
    TreeFam Gene Tree for PPME1 (if available) 

    Paralogs
    for PPME1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PPME1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1183 NCBI SNPs in PPME1 are shown (see all 1183)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs79255001,2
    		C,--73884402(+) AATCAG/TATTTT 2 -- int10--------
    rs800865661,2
    		F,--73884403(+) ATCAGA/CTTTTT 2 -- int11Minor allele frequency- C:0.03NA 120
    rs1929614571,2
    		--73884455(+) CTTCTC/TATCTT 2 -- int10--------
    rs1140377201,2
    		F,--73884461(+) ATCTTG/TGAGAA 2 -- int11Minor allele frequency- T:0.04WA 118
    rs1847794951,2
    		--73884618(+) GTCTCA/GCTCTG 2 -- int10--------
    rs1896456811,2
    		--73884709(+) AGCCTC/TCCAAG 2 -- int10--------
    rs1925250141,2
    		--73884733(+) AGGCAC/TGCACC 2 -- int10--------
    rs1396206381,2
    		--73884783(+) GATTTC/GGCCAT 2 -- int10--------
    rs1837655281,2
    		--73884900(+) TTTTTA/TAAAAG 2 -- int10--------
    rs1884413091,2
    		--73884970(+) AAGGCC/TTTTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PPME1 (73882144 - 73965748 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PPME1
         3 CNVs: 2932 3858 8692

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPME1
    DNA2.0 Custom Variant and Variant Library Synthesis for PPME1

    Disorders / Diseases
    for PPME1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPME1 for disorders           About GeneDecksing

    OMIM gene information: 611117    OMIM disorders: --

    6 diseases for PPME1:    About MalaCards
    unverricht-lundborg syndrome    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3
    malignant glioma    cerebritis

    1 disease from the University of Copenhagen DISEASES database for PPME1:
    Unverricht-Lundborg syndrome

    Export disorders for PPME1 gene to outside databases

    Publications
    for PPME1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPME1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with PPME1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PubMed id 10318862)1, 2, 3, 9 Ogris E....Pallas D.C. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. (PubMed id 19293187)1, 9 Puustinen P....Westermarck J. (2009)
    6. Spatial control of protein phosphatase 2A (de)methylation. (PubMed id 17803990)1, 9 Longin S....Janssens V. (2008)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Glycogen synthase kinase-3b regulates leucine-309 deme thylation of protein phosphatase-2A via PPMT1 and PME-1. (PubMed id 22732552)1 Yao X.Q....Liu G.P. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Academic cross-fertilization by public screening yiel ds a remarkable class of protein phosphatase methylesterase-1 inhibitors. (PubMed id 21398589)1 Bachovchin D.A....Cravatt B.F. (2011)

    External Searches for PPME1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PPME1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51400 HGNC: 30178 AceView: PME-1 Ensembl:ENSG00000214517 euGenes: HUgn51400
    ECgene: PPME1 H-InvDB: PPME1

    Other Databases showing PPME1 gene

    (According to HUGE)
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    Specialized Databases showing PPME1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPME1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PPME1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPME1 gene:
    Search GeneIP for patents involving PPME1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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