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Aliases for PPME1 Gene

Aliases for PPME1 Gene

  • Protein Phosphatase Methylesterase 1 2 3
  • PME-1 3 4
  • Protein Phosphatase Methylesterase-1 3
  • EC 3.1.1.89 4
  • EC 3.1.1 63
  • PME1 4

External Ids for PPME1 Gene

Previous GeneCards Identifiers for PPME1 Gene

  • GC11P073560
  • GC11P073882
  • GC11P070177

Summaries for PPME1 Gene

Entrez Gene Summary for PPME1 Gene

  • This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for PPME1 Gene

PPME1 (Protein Phosphatase Methylesterase 1) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPME1 Gene

  • Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPME1 Gene

Genomics for PPME1 Gene

Regulatory Elements for PPME1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPME1 Gene

Chromosome:
11
Start:
74,170,891 bp from pter
End:
74,254,703 bp from pter
Size:
83,813 bases
Orientation:
Plus strand

Genomic View for PPME1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPME1 Gene

Proteins for PPME1 Gene

  • Protein details for PPME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y570-PPME1_HUMAN
    Recommended name:
    Protein phosphatase methylesterase 1
    Protein Accession:
    Q9Y570
    Secondary Accessions:
    • B3KMU6
    • B5MEE7
    • J3QT22
    • Q8WYG8
    • Q9NVT5
    • Q9UI18

    Protein attributes for PPME1 Gene

    Size:
    386 amino acids
    Molecular mass:
    42315 Da
    Quaternary structure:
    • Binds PPP2CA and PPP2CB.
    SequenceCaution:
    • Sequence=AAG22477.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPME1 Gene

    Alternative splice isoforms for PPME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPME1 Gene

Proteomics data for PPME1 Gene at MOPED

Selected DME Specific Peptides for PPME1 Gene

Post-translational modifications for PPME1 Gene

  • Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPME1 Gene

Antibody Products

Domains & Families for PPME1 Gene

Protein Domains for PPME1 Gene

Suggested Antigen Peptide Sequences for PPME1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y570

UniProtKB/Swiss-Prot:

PPME1_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with PPME1: view

No data available for Gene Families for PPME1 Gene

Function for PPME1 Gene

Molecular function for PPME1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol.
UniProtKB/Swiss-Prot Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

Enzyme Numbers (IUBMB) for PPME1 Gene

Gene Ontology (GO) - Molecular Function for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity TAS 10318862
GO:0008601 protein phosphatase type 2A regulator activity TAS 10318862
GO:0019901 protein kinase binding IEA --
GO:0019903 protein phosphatase binding IDA 10318862
GO:0051721 protein phosphatase 2A binding IDA 10318862
genes like me logo Genes that share ontologies with PPME1: view
genes like me logo Genes that share phenotypes with PPME1: view

Animal Models for PPME1 Gene

MGI Knock Outs for PPME1:

Animal Model Products

miRNA for PPME1 Gene

miRTarBase miRNAs that target PPME1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPME1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PPME1 Gene

Localization for PPME1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PPME1 Gene

Pathways & Interactions for PPME1 Gene

SuperPathways for PPME1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006482 protein demethylation IDA 10318862
GO:0034047 regulation of protein phosphatase type 2A activity TAS 10318862
GO:0043086 negative regulation of catalytic activity TAS 10318862
genes like me logo Genes that share ontologies with PPME1: view

No data available for Pathways by source and SIGNOR curated interactions for PPME1 Gene

Drugs & Compounds for PPME1 Gene

(2) Additional Compounds for PPME1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
methanol
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
67-56-1
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPME1: view

Transcripts for PPME1 Gene

Unigene Clusters for PPME1 Gene

Protein phosphatase methylesterase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPME1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPME1 Gene

No ASD Table

Relevant External Links for PPME1 Gene

GeneLoc Exon Structure for
PPME1
ECgene alternative splicing isoforms for
PPME1

Expression for PPME1 Gene

mRNA expression in normal human tissues for PPME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPME1 Gene

This gene is overexpressed in Frontal cortex (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPME1 Gene



SOURCE GeneReport for Unigene cluster for PPME1 Gene Hs.503251

genes like me logo Genes that share expression patterns with PPME1: view

Protein tissue co-expression partners for PPME1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPME1 Gene

Orthologs for PPME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPME1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPME1 35
  • 95.18 (n)
  • 98.68 (a)
PPME1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPME1 35
  • 94.3 (n)
  • 98.45 (a)
PPME1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppme1 35
  • 91.71 (n)
  • 97.93 (a)
Ppme1 16
Ppme1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPME1 35
  • 99.83 (n)
  • 100 (a)
PPME1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppme1 35
  • 91.45 (n)
  • 97.93 (a)
oppossum
(Monodelphis domestica)
Mammalia PPME1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPME1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPME1 35
  • 81.74 (n)
  • 91.85 (a)
PPME1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPME1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppme1 35
  • 76.04 (n)
  • 86.46 (a)
zebrafish
(Danio rerio)
Actinopterygii ppme1 35
  • 71.05 (n)
  • 79.36 (a)
wufk72d03 35
ppme1 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008336 35
  • 52.7 (n)
  • 50.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5068 35
  • 54.05 (n)
  • 51.08 (a)
CG5068 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0464.9 35
  • 55.56 (n)
  • 51.49 (a)
B0464.9 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR359C 35
  • 48.62 (n)
  • 37.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13046g 35
  • 47.91 (n)
  • 35.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPE1 35
  • 46.01 (n)
  • 35.78 (a)
PPE1 36
  • 25 (a)
OneToOne
PPE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10050 35
  • 54.17 (n)
  • 51.01 (a)
soybean
(Glycine max)
eudicotyledons Gma.2947 35
barley
(Hordeum vulgare)
Liliopsida Hv.4161 35
rice
(Oryza sativa)
Liliopsida Os.18761 35
Os04g0443500 35
  • 54.76 (n)
  • 48.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00954 35
  • 48.16 (n)
  • 46.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP4H10.17c 35
  • 52.55 (n)
  • 44.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for PPME1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPME1 Gene

ENSEMBL:
Gene Tree for PPME1 (if available)
TreeFam:
Gene Tree for PPME1 (if available)

Paralogs for PPME1 Gene

(1) SIMAP similar genes for PPME1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPME1: view

No data available for Paralogs for PPME1 Gene

Variants for PPME1 Gene

Sequence variations from dbSNP and Humsavar for PPME1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs113525320 -- 74,204,146(+) GGGAA(-/TG)TTTTT intron-variant
rs113390090 -- 74,244,936(+) TCCCA(A/G)TACTG intron-variant
rs113380659 -- 74,185,061(+) GTGGC(A/G)CAATC intron-variant
rs113290970 -- 74,217,748(+) AAAAA(A/G)AAAAC intron-variant
rs113290403 -- 74,241,439(+) ATACT(A/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPME1 Gene

Variant ID Type Subtype PubMed ID
dgv397e1 CNV Complex 17122850
esv34979 CNV Gain 17911159
nsv522994 CNV Loss 19592680
nsv825994 CNV Gain 20364138
esv269607 CNV Insertion 20981092
esv2744775 CNV Deletion 23290073

Variation tolerance for PPME1 Gene

Residual Variation Intolerance Score: 68.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPME1 Gene

HapMap Linkage Disequilibrium report
PPME1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPME1 Gene

Disorders for PPME1 Gene

Relevant External Links for PPME1

Genetic Association Database (GAD)
PPME1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPME1
genes like me logo Genes that share disorders with PPME1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPME1 Gene

Publications for PPME1 Gene

  1. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PMID: 10318862) Ogris E. … Pallas D.C. (J. Biol. Chem. 1999) 2 23 67
  2. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. (PMID: 19293187) Puustinen P. … Westermarck J. (Cancer Res. 2009) 23 67
  3. Spatial control of protein phosphatase 2A (de)methylation. (PMID: 17803990) Longin S. … Janssens V. (Exp. Cell Res. 2008) 23 67
  4. Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B). (PMID: 17274953) Ikehara T. … Yasumoto T. (Biochem. Biophys. Res. Commun. 2007) 23 67
  5. An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator. (PMID: 14748741) Longin S. … Van Hoof C. (Biochem. J. 2004) 23 67

Products for PPME1 Gene

Sources for PPME1 Gene

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