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Aliases for PPME1 Gene

Aliases for PPME1 Gene

  • Protein Phosphatase Methylesterase 1 2 3
  • PME-1 3 4
  • Protein Phosphatase Methylesterase-1 3
  • EC 3.1.1.89 4
  • EC 3.1.1 64
  • PME1 4

External Ids for PPME1 Gene

Summaries for PPME1 Gene

Entrez Gene Summary for PPME1 Gene

  • This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for PPME1 Gene

PPME1 (Protein Phosphatase Methylesterase 1) is a Protein Coding gene. Diseases associated with PPME1 include malignant glioma and unverricht-lundborg syndrome. GO annotations related to this gene include protein kinase binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPME1 Gene

  • Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPME1 Gene

Genomics for PPME1 Gene

Genomic Location for PPME1 Gene

Start:
74,170,891 bp from pter
End:
74,254,703 bp from pter
Size:
83,813 bases
Orientation:
Plus strand

Genomic View for PPME1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPME1 Gene

Regulatory Elements for PPME1 Gene

Proteins for PPME1 Gene

  • Protein details for PPME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y570-PPME1_HUMAN
    Recommended name:
    Protein phosphatase methylesterase 1
    Protein Accession:
    Q9Y570
    Secondary Accessions:
    • B3KMU6
    • B5MEE7
    • J3QT22
    • Q8WYG8
    • Q9NVT5
    • Q9UI18

    Protein attributes for PPME1 Gene

    Size:
    386 amino acids
    Molecular mass:
    42315 Da
    Quaternary structure:
    • Binds PPP2CA and PPP2CB.
    SequenceCaution:
    • Sequence=AAG22477.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPME1 Gene

    Alternative splice isoforms for PPME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPME1 Gene

Proteomics data for PPME1 Gene at MOPED

Selected DME Specific Peptides for PPME1 Gene

Post-translational modifications for PPME1 Gene

  • Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPME1 Gene

Domains for PPME1 Gene

Protein Domains for PPME1 Gene

UniProtKB/Swiss-Prot:

PPME1_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily.:
    • Q9Y570
genes like me logo Genes that share domains with PPME1: view

No data available for Gene Families for PPME1 Gene

Function for PPME1 Gene

Molecular function for PPME1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: [Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol.
UniProtKB/Swiss-Prot Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

Enzyme Numbers (IUBMB) for PPME1 Gene

Gene Ontology (GO) - Molecular Function for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity TAS 10318862
GO:0008601 protein phosphatase type 2A regulator activity TAS 10318862
GO:0019903 protein phosphatase binding IDA 10318862
GO:0051721 protein phosphatase 2A binding IDA 10318862
GO:0051722 protein C-terminal methylesterase activity IDA 10318862
genes like me logo Genes that share ontologies with PPME1: view
genes like me logo Genes that share phenotypes with PPME1: view

Animal Models for PPME1 Gene

MGI Knock Outs for PPME1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PPME1 Gene

Localization for PPME1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPME1 Gene COMPARTMENTS Subcellular localization image for PPME1 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PPME1 Gene

Pathways for PPME1 Gene

SuperPathways for PPME1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006482 protein demethylation IDA 10318862
GO:0034047 regulation of protein phosphatase type 2A activity TAS 10318862
GO:0043086 negative regulation of catalytic activity TAS 10318862
GO:0050790 regulation of catalytic activity --
genes like me logo Genes that share ontologies with PPME1: view

No data available for Pathways by source for PPME1 Gene

Transcripts for PPME1 Gene

Unigene Clusters for PPME1 Gene

Protein phosphatase methylesterase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPME1 Gene

No ASD Table

Relevant External Links for PPME1 Gene

GeneLoc Exon Structure for
PPME1
ECgene alternative splicing isoforms for
PPME1

Expression for PPME1 Gene

mRNA expression in normal human tissues for PPME1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPME1 Gene

SOURCE GeneReport for Unigene cluster for PPME1 Gene Hs.503251

genes like me logo Genes that share expressions with PPME1: view

Orthologs for PPME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPME1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPME1 36
  • 99.83 (n)
  • 100 (a)
PPME1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPME1 36
  • 95.18 (n)
  • 98.68 (a)
PPME1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPME1 36
  • 94.3 (n)
  • 98.45 (a)
PPME1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppme1 36
  • 91.71 (n)
  • 97.93 (a)
Ppme1 16
Ppme1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPME1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPME1 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppme1 36
  • 91.45 (n)
  • 97.93 (a)
chicken
(Gallus gallus)
Aves PPME1 36
  • 81.74 (n)
  • 91.85 (a)
PPME1 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPME1 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppme1 36
  • 76.04 (n)
  • 86.46 (a)
zebrafish
(Danio rerio)
Actinopterygii ppme1 36
  • 71.05 (n)
  • 79.36 (a)
ppme1 37
  • 77 (a)
OneToOne
wufk72d03 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008336 36
  • 52.7 (n)
  • 50.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5068 36
  • 54.05 (n)
  • 51.08 (a)
CG5068 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0464.9 36
  • 55.56 (n)
  • 51.49 (a)
B0464.9 37
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR359C 36
  • 48.62 (n)
  • 37.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPE1 36
  • 46.01 (n)
  • 35.78 (a)
PPE1 37
  • 25 (a)
OneToOne
PPE1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13046g 36
  • 47.91 (n)
  • 35.13 (a)
soybean
(Glycine max)
eudicotyledons Gma.2947 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10050 36
  • 54.17 (n)
  • 51.01 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4161 36
rice
(Oryza sativa)
Liliopsida Os.18761 36
Os04g0443500 36
  • 54.76 (n)
  • 48.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00954 36
  • 48.16 (n)
  • 46.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP4H10.17c 36
  • 52.55 (n)
  • 44.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for PPME1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPME1 Gene

ENSEMBL:
Gene Tree for PPME1 (if available)
TreeFam:
Gene Tree for PPME1 (if available)

Paralogs for PPME1 Gene

Selected SIMAP similar genes for PPME1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPME1: view

No data available for Paralogs for PPME1 Gene

Variants for PPME1 Gene

Sequence variations from dbSNP and Humsavar for PPME1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs474835 -- 74,245,752(+) ATGAA(A/G)CATCC intron-variant
rs478893 -- 74,203,830(-) TTTGC(A/C)AAGGA intron-variant
rs478913 -- 74,242,020(-) atacc(A/C)aaagt intron-variant
rs481170 -- 74,208,377(-) agggg(G/T)ttagt intron-variant
rs481921 -- 74,208,343(-) TTATT(A/T)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPME1 Gene

Variant ID Type Subtype PubMed ID
dgv397e1 CNV Complex 17122850
esv34979 CNV Gain 17911159
nsv522994 CNV Loss 19592680
nsv825994 CNV Gain 20364138
esv269607 CNV Insertion 20981092
esv2744775 CNV Deletion 23290073

Relevant External Links for PPME1 Gene

HapMap Linkage Disequilibrium report
PPME1

Disorders for PPME1 Gene

(1) University of Copenhagen DISEASES for PPME1 Gene

Relevant External Links for PPME1

Genetic Association Database (GAD)
PPME1
genes like me logo Genes that share disorders with PPME1: view

No data available for UniProtKB/Swiss-Prot for PPME1 Gene

Publications for PPME1 Gene

  1. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PMID: 10318862) Ogris E. … Pallas D.C. (J. Biol. Chem. 1999) 2 3 4 23
  2. Spatial control of protein phosphatase 2A (de)methylation. (PMID: 17803990) Longin S. … Janssens V. (Exp. Cell Res. 2008) 3 23
  3. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. (PMID: 19293187) Puustinen P. … Westermarck J. (Cancer Res. 2009) 3 23
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PPME1 Gene

Sources for PPME1 Gene

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