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Aliases for PPME1 Gene

Aliases for PPME1 Gene

  • Protein Phosphatase Methylesterase 1 2 3 5
  • PME-1 3 4
  • Testicular Secretory Protein Li 39 3
  • EC 4
  • EC 3.1.1 58
  • PME1 4

External Ids for PPME1 Gene

Previous GeneCards Identifiers for PPME1 Gene

  • GC11P073560
  • GC11P073882
  • GC11P070177

Summaries for PPME1 Gene

Entrez Gene Summary for PPME1 Gene

  • This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for PPME1 Gene

PPME1 (Protein Phosphatase Methylesterase 1) is a Protein Coding gene. Diseases associated with PPME1 include Malignant Glioma. GO annotations related to this gene include protein phosphatase binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPME1 Gene

  • Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

Additional gene information for PPME1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPME1 Gene

Genomics for PPME1 Gene

Regulatory Elements for PPME1 Gene

Enhancers for PPME1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H074133 1.5 Ensembl ENCODE dbSUPER 32.3 -32.6 -32634 10.2 FOXA2 ARID4B BRCA1 GLIS2 FOS DEK REST ZNF592 MIER3 SMARCA4 PPME1 P4HA3 C2CD3 UCP3 UCP2 ENSG00000206913 ENSG00000256098
GH11H074169 1.4 ENCODE dbSUPER 17.2 +0.6 569 3.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A YBX1 DMAP1 YY1 ENSG00000206913 POLD3 P4HA3 RNF169 PPME1 PAAF1 C2CD3 GC11P074171
GH11H074162 1 FANTOM5 ENCODE dbSUPER 20.4 -7.8 -7833 1.1 JUNB EBF1 BATF PPME1 ENSG00000256098
GH11H073992 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -175.3 -175299 5.4 MAX CHD1 RBBP5 REST ELF1 BATF IKZF1 NBN ETV6 RUNX3 P4HA3 PPME1 ENSG00000255847 PAAF1 UCP2 LIPT2 C2CD3 LOC100421622 LOC100037267
GH11H074003 1 Ensembl ENCODE dbSUPER 17.7 -165.6 -165638 2.5 L3MBTL2 RUNX3 MGA PPME1 P4HA3 UCP3 LOC100421622
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPME1 on UCSC Golden Path with GeneCards custom track

Promoters for PPME1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for PPME1 Gene

Genomic Locations for PPME1 Gene
83,813 bases
Plus strand

Genomic View for PPME1 Gene

Genes around PPME1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPME1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPME1 Gene

Proteins for PPME1 Gene

  • Protein details for PPME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase methylesterase 1
    Protein Accession:
    Secondary Accessions:
    • B3KMU6
    • B5MEE7
    • J3QT22
    • Q8WYG8
    • Q9NVT5
    • Q9UI18

    Protein attributes for PPME1 Gene

    386 amino acids
    Molecular mass:
    42315 Da
    Quaternary structure:
    • Binds PPP2CA and PPP2CB.
    • Sequence=AAG22477.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPME1 Gene

    Alternative splice isoforms for PPME1 Gene


neXtProt entry for PPME1 Gene

Selected DME Specific Peptides for PPME1 Gene


Post-translational modifications for PPME1 Gene

  • Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPME1 Gene

Domains & Families for PPME1 Gene

Gene Families for PPME1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPME1 Gene

Suggested Antigen Peptide Sequences for PPME1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily.
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with PPME1: view

Function for PPME1 Gene

Molecular function for PPME1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol.
UniProtKB/Swiss-Prot Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

Enzyme Numbers (IUBMB) for PPME1 Gene

Phenotypes From GWAS Catalog for PPME1 Gene

Gene Ontology (GO) - Molecular Function for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity TAS 10318862
GO:0016787 hydrolase activity IEA --
GO:0019888 protein phosphatase regulator activity TAS 10318862
GO:0019901 protein kinase binding IEA --
GO:0019903 protein phosphatase binding IDA 10318862
genes like me logo Genes that share ontologies with PPME1: view
genes like me logo Genes that share phenotypes with PPME1: view

Animal Models for PPME1 Gene

MGI Knock Outs for PPME1:

Animal Model Products

CRISPR Products

miRNA for PPME1 Gene

miRTarBase miRNAs that target PPME1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPME1 Gene

Localization for PPME1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPME1 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPME1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPME1 Gene

Pathways & Interactions for PPME1 Gene

SuperPathways for PPME1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006482 protein demethylation IDA 10318862
GO:0043086 negative regulation of catalytic activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPME1: view

No data available for Pathways by source and SIGNOR curated interactions for PPME1 Gene

Drugs & Compounds for PPME1 Gene

(1) Drugs for PPME1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(1) Additional Compounds for PPME1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
genes like me logo Genes that share compounds with PPME1: view

Transcripts for PPME1 Gene

Unigene Clusters for PPME1 Gene

Protein phosphatase methylesterase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPME1 Gene

No ASD Table

Relevant External Links for PPME1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPME1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPME1 Gene

This gene is overexpressed in Frontal cortex (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPME1 Gene

Protein tissue co-expression partners for PPME1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPME1 Gene:


SOURCE GeneReport for Unigene cluster for PPME1 Gene:


Evidence on tissue expression from TISSUES for PPME1 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Skin(4.6)
  • Blood(4.2)
  • Kidney(4.2)
  • Liver(4.2)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with PPME1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPME1 Gene

Orthologs for PPME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPME1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPME1 33 34
  • 99.83 (n)
(Bos Taurus)
Mammalia PPME1 33 34
  • 95.18 (n)
(Canis familiaris)
Mammalia PPME1 33 34
  • 94.3 (n)
(Monodelphis domestica)
Mammalia PPME1 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia PPME1 34
  • 92 (a)
(Mus musculus)
Mammalia Ppme1 33 16 34
  • 91.71 (n)
(Rattus norvegicus)
Mammalia Ppme1 33
  • 91.45 (n)
(Gallus gallus)
Aves PPME1 33 34
  • 81.74 (n)
(Anolis carolinensis)
Reptilia PPME1 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppme1 33
  • 76.04 (n)
(Danio rerio)
Actinopterygii ppme1 33 34
  • 71.05 (n)
wufk72d03 33
fruit fly
(Drosophila melanogaster)
Insecta CG5068 33 34
  • 54.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008336 33
  • 52.7 (n)
(Caenorhabditis elegans)
Secernentea B0464.9 33 34
  • 55.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR359C 33
  • 48.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13046g 33
  • 47.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPE1 33 34 36
  • 46.01 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10050 33
  • 54.17 (n)
(Glycine max)
eudicotyledons Gma.2947 33
(Oryza sativa)
Liliopsida Os04g0443500 33
  • 54.76 (n)
Os.18761 33
(Hordeum vulgare)
Liliopsida Hv.4161 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP4H10.17c 33
  • 52.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00954 33
  • 48.16 (n)
Species where no ortholog for PPME1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPME1 Gene

Gene Tree for PPME1 (if available)
Gene Tree for PPME1 (if available)

Paralogs for PPME1 Gene

(1) SIMAP similar genes for PPME1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPME1: view

No data available for Paralogs for PPME1 Gene

Variants for PPME1 Gene

Sequence variations from dbSNP and Humsavar for PPME1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000012989 -- 74,245,454(+) ATTGC(A/G)TACTC intron-variant
rs1000014785 -- 74,229,298(+) ACCAG(C/G)CACTC intron-variant
rs1000084104 -- 74,196,742(+) TGTAT(A/G)TATGG intron-variant
rs1000087998 -- 74,231,169(+) CCTCC(C/T)ACCTC intron-variant
rs1000094759 -- 74,246,379(+) GCCTT(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPME1 Gene

Variant ID Type Subtype PubMed ID
nsv825994 CNV gain 20364138
nsv522994 CNV loss 19592680
esv3626835 CNV gain 21293372
esv3626833 CNV gain 21293372
esv3626832 CNV loss 21293372
esv3548003 CNV deletion 23714750
esv34979 CNV gain 17911159
esv3395722 CNV insertion 20981092
esv3305329 CNV mobile element insertion 20981092
esv2759837 CNV gain 17122850
esv2744775 CNV deletion 23290073
dgv209e214 CNV gain 21293372

Variation tolerance for PPME1 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPME1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPME1 Gene

Disorders for PPME1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPME1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malignant glioma
  • glial cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search PPME1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPME1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPME1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPME1 Gene

Publications for PPME1 Gene

  1. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PMID: 10318862) Ogris E … Pallas DC (The Journal of biological chemistry 1999) 2 3 4 22 60
  2. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. (PMID: 19293187) Puustinen P … Westermarck J (Cancer research 2009) 3 22 60
  3. Spatial control of protein phosphatase 2A (de)methylation. (PMID: 17803990) Longin S … Janssens V (Experimental cell research 2008) 3 22 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for PPME1 Gene

Sources for PPME1 Gene

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