Aliases for PPM1L Gene
External Ids for PPM1L Gene
Previous GeneCards Identifiers for PPM1L Gene
PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).[supplied by OMIM, Apr 2008]
GeneCards Summary for PPM1L Gene
PPM1L (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1L) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E.
UniProtKB/Swiss-Prot for PPM1L Gene
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.