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Aliases for PPM1L Gene

Aliases for PPM1L Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1L 2 3 5
  • Protein Phosphatase 2C Epsilon Isoform 2 3
  • Protein Phosphatase 2C Isoform Epsilon 3 4
  • PP2C-Epsilon 3 4
  • EC 4 56
  • PP2CE 3 4
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1L 2
  • Protein Phosphatase 1 (Formerly 2C)-Like 2
  • Protein Phosphatase 1-Like 4
  • Protein Phosphatase 1L 3
  • PP2C Epsilon 3
  • PP2Cepsilon 2
  • PPM1-LIKE 3
  • EC 3.1.3 56

External Ids for PPM1L Gene

Previous GeneCards Identifiers for PPM1L Gene

  • GC03P161880
  • GC03P162042
  • GC03P160473
  • GC03P157872

Summaries for PPM1L Gene

Entrez Gene Summary for PPM1L Gene

  • The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for PPM1L Gene

PPM1L (Protein Phosphatase, Mg2+/Mn2+ Dependent 1L) is a Protein Coding gene. Among its related pathways are Metabolism and Development Dopamine D2 receptor transactivation of EGFR. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1F.

UniProtKB/Swiss-Prot for PPM1L Gene

  • Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.

Additional gene information for PPM1L Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1L Gene

Genomics for PPM1L Gene

GeneHancer (GH) Regulatory Elements for PPM1L Gene

Promoters and enhancers for PPM1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I160754 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 379 3.4 CLOCK ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 SP3 SP5 REST ENSG00000260572 PPM1L SMC4 SPTSSB PIR58593
GH03I160935 Enhancer 0.8 ENCODE 11.4 +180.0 180036 0.2 ELF3 FOXA2 DNMT3B ZNF48 RAD21 YY1 FOS RCOR1 THAP11 RXRA PPM1L ARL14 PIR58593
GH03I160800 Enhancer 0.9 Ensembl ENCODE 4.8 +46.3 46291 1.7 ZSCAN4 BATF IRF4 ZNF316 POLR2A ZBTB48 ZNF600 IKZF2 RUNX3 MAFK PPM1L PIR58593
GH03I160797 Enhancer 0.8 ENCODE 4.8 +41.4 41386 0.2 FOXA2 ZSCAN4 INSM2 KLF17 SIN3A FEZF1 RAD21 YY1 ZNF335 ATF7 PPM1L PIR58593
GH03I160796 Enhancer 0.8 ENCODE 4.5 +41.0 40968 0.6 FOXA2 ZSCAN4 INSM2 KLF17 SIN3A RAD21 YY1 ZNF335 ATF7 ZNF398 SPTSSB PPM1L PIR58593
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPM1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPM1L gene promoter:

Genomic Locations for PPM1L Gene

Genomic Locations for PPM1L Gene
323,376 bases
Plus strand

Genomic View for PPM1L Gene

Genes around PPM1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1L Gene

Proteins for PPM1L Gene

  • Protein details for PPM1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1L
    Protein Accession:
    Secondary Accessions:
    • Q2M3J2
    • Q96NM7

    Protein attributes for PPM1L Gene

    360 amino acids
    Molecular mass:
    41053 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.

    Alternative splice isoforms for PPM1L Gene


neXtProt entry for PPM1L Gene

Selected DME Specific Peptides for PPM1L Gene


Post-translational modifications for PPM1L Gene

No Post-translational modifications

Other Protein References for PPM1L Gene

Domains & Families for PPM1L Gene

Gene Families for PPM1L Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PPM1L Gene

Suggested Antigen Peptide Sequences for PPM1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PP2C family.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1L: view

Function for PPM1L Gene

Molecular function for PPM1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.

Enzyme Numbers (IUBMB) for PPM1L Gene

Phenotypes From GWAS Catalog for PPM1L Gene

Gene Ontology (GO) - Molecular Function for PPM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with PPM1L: view
genes like me logo Genes that share phenotypes with PPM1L: view

Animal Models for PPM1L Gene

MGI Knock Outs for PPM1L:

Animal Model Products

CRISPR Products

miRNA for PPM1L Gene

miRTarBase miRNAs that target PPM1L

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPM1L Gene

Localization for PPM1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1L Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1L gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 3
cytosol 3
mitochondrion 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 19199708
genes like me logo Genes that share ontologies with PPM1L: view

Pathways & Interactions for PPM1L Gene

genes like me logo Genes that share pathways with PPM1L: view

Pathways by source for PPM1L Gene

1 R&D Systems pathway for PPM1L Gene
1 Qiagen pathway for PPM1L Gene

SIGNOR curated interactions for PPM1L Gene


Gene Ontology (GO) - Biological Process for PPM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with PPM1L: view

Drugs & Compounds for PPM1L Gene

(4) Drugs for PPM1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
genes like me logo Genes that share compounds with PPM1L: view

Transcripts for PPM1L Gene

Unigene Clusters for PPM1L Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1L:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1L Gene

No ASD Table

Relevant External Links for PPM1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPM1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1L Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for PPM1L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.9), Frontal cortex (13.7), Liver (8.2), and Islet of Langerhans (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPM1L Gene

Protein tissue co-expression partners for PPM1L Gene

NURSA nuclear receptor signaling pathways regulating expression of PPM1L Gene:


SOURCE GeneReport for Unigene cluster for PPM1L Gene:


mRNA Expression by UniProt/SwissProt for PPM1L Gene:

Tissue specificity: Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.

Evidence on tissue expression from TISSUES for PPM1L Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PPM1L: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1L Gene

Orthologs for PPM1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPM1L 33 34
  • 99.54 (n)
(Monodelphis domestica)
Mammalia PPM1L 34
  • 98 (a)
(Canis familiaris)
Mammalia PPM1L 33 34
  • 95.19 (n)
(Bos Taurus)
Mammalia PPM1L 33 34
  • 94.07 (n)
(Mus musculus)
Mammalia Ppm1l 33 16 34
  • 91.2 (n)
(Rattus norvegicus)
Mammalia Ppm1l 33
  • 91.02 (n)
(Ornithorhynchus anatinus)
Mammalia PPM1L 34
  • 83 (a)
(Gallus gallus)
Aves PPM1L 33 34
  • 84.72 (n)
(Anolis carolinensis)
Reptilia PPM1L 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1l 33
  • 82.87 (n)
Str.16930 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26315 33
(Danio rerio)
Actinopterygii ppm1la 33 34
  • 77.75 (n)
ppm1lb 34
  • 70 (a)
Dr.7261 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6639 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008536 33
  • 55.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7115 33 34
  • 52.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 34
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G24940 33
  • 50.28 (n)
(Oryza sativa)
Liliopsida Os06g0698300 33
  • 50.14 (n)
Species where no ortholog for PPM1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPM1L Gene

Gene Tree for PPM1L (if available)
Gene Tree for PPM1L (if available)

Paralogs for PPM1L Gene

Paralogs for PPM1L Gene

genes like me logo Genes that share paralogs with PPM1L: view

Variants for PPM1L Gene

Sequence variations from dbSNP and Humsavar for PPM1L Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000012648 -- 160,818,440(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000018841 -- 161,054,118(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000049234 -- 160,776,862(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000050054 -- 160,820,132(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000050529 -- 160,917,904(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1L Gene

Variant ID Type Subtype PubMed ID
dgv8662n54 CNV loss 21841781
esv1469152 CNV deletion 17803354
esv1495071 CNV insertion 17803354
esv2121069 CNV deletion 18987734
esv24553 CNV loss 19812545
esv2476287 CNV deletion 19546169
esv2519831 CNV deletion 19546169
esv2647987 CNV deletion 19546169
esv2657324 CNV deletion 23128226
esv2665188 CNV deletion 23128226
esv2672481 CNV deletion 23128226
esv2674643 CNV deletion 23128226
esv2726116 CNV deletion 23290073
esv2726118 CNV deletion 23290073
esv32963 CNV gain 17666407
esv3305379 CNV mobile element insertion 20981092
esv3430004 CNV insertion 20981092
esv3441804 CNV duplication 20981092
esv3562806 CNV deletion 23714750
esv3562807 CNV deletion 23714750
esv3562809 CNV deletion 23714750
esv3569081 CNV loss 25503493
esv3569082 CNV loss 25503493
esv3598389 CNV loss 21293372
esv3598390 CNV loss 21293372
esv3598395 CNV loss 21293372
esv3598396 CNV loss 21293372
esv3598397 CNV loss 21293372
esv3598398 CNV loss 21293372
esv994945 CNV deletion 20482838
nsv1007004 CNV loss 25217958
nsv1073691 CNV deletion 25765185
nsv1114444 CNV deletion 24896259
nsv477622 CNV novel sequence insertion 20440878
nsv507133 OTHER sequence alteration 20534489
nsv517658 CNV loss 19592680
nsv518915 CNV loss 19592680
nsv519474 CNV loss 19592680
nsv592128 CNV loss 21841781
nsv592129 CNV loss 21841781
nsv592135 CNV loss 21841781
nsv967245 CNV deletion 23825009
nsv979895 CNV duplication 23825009

Variation tolerance for PPM1L Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPM1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1L Gene

Disorders for PPM1L Gene

Additional Disease Information for PPM1L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPM1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1L Gene

Publications for PPM1L Gene

  1. Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*). (PMID: 15560375) Jin F … Mao Y (Molecular biology reports 2004) 3 4 22 58
  2. Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). (PMID: 12556533) Li MG … Tamura S (The Journal of biological chemistry 2003) 2 3 22 58
  3. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. (PMID: 22446961) Lee YC … Wu JY (Nature genetics 2012) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. (PMID: 18165232) Saito S … Kobayashi T (The Journal of biological chemistry 2008) 3 22 58

Products for PPM1L Gene

Sources for PPM1L Gene

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