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Aliases for PPM1J Gene

Aliases for PPM1J Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1J 2 3 5
  • Protein Phosphatase 1J (PP2C Domain Containing) 2 3
  • Protein Phosphatase 2C Isoform Zeta 3 4
  • Protein Phosphatase 2C Zeta 2 3
  • EC 3.1.3.16 4 58
  • PP2C-Zeta 3 4
  • PPP2CZ 3 4
  • Protein Phosphatase 2a, Catalytic Subunit, Zeta Isoform 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1J 2
  • Protein Phosphatase 1J 3
  • PP2Czeta 3
  • PP2CZ 3

External Ids for PPM1J Gene

Previous GeneCards Identifiers for PPM1J Gene

  • GC01M112965
  • GC01M113252
  • GC01M111111
  • GC01M113245

Summaries for PPM1J Gene

Entrez Gene Summary for PPM1J Gene

  • This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1J Gene

PPM1J (Protein Phosphatase, Mg2+/Mn2+ Dependent 1J) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Direct p53 effectors. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1H.

Additional gene information for PPM1J Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1J Gene

Genomics for PPM1J Gene

Regulatory Elements for PPM1J Gene

Enhancers for PPM1J Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H113040 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -326.9 -326863 4.1 PKNOX1 ATF1 ARNT ARID4B DMAP1 TCF12 ZNF766 GATA2 ELK1 ZNF143 LRIG2 LOC100996251 SLC16A1 RHOC PPM1J RPS15P1 GC01P113034 PIRC4
GH01H112816 1.5 Ensembl ENCODE dbSUPER 11 -104.3 -104292 6.8 HDGF PKNOX1 ATF1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GLIS2 GATA2 LRIG2 LOC100421402 ST7L PPM1J RHOC LOC100996251 ENSG00000225075 MOV10 KCND3 LINC01356
GH01H112807 1.3 Ensembl ENCODE dbSUPER 12.4 -93.4 -93382 3.5 HDGF RB1 ZNF2 RAD21 EGR1 ZNF143 ATF7 DEK EGR2 SMARCA5 PPM1J RHOC HP08777 GC01P112820 GC01M112752
GH01H112388 1.5 Ensembl ENCODE dbSUPER 10.1 +324.9 324940 3.5 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS KLF7 ATF7 WNT2B CTTNBP2NL RHOC PPM1J LINC01160 GC01P112392 ENSG00000238761
GH01H112617 1.4 ENCODE dbSUPER 10.5 +95.2 95165 6.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ST7L LOC100421402 KCND3-AS1 LRIG2 CAPZA1 RPS15P1 LOC105378910 MOV10 ENSG00000225075 RHOC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPM1J on UCSC Golden Path with GeneCards custom track

Promoters for PPM1J Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011517 277 2001 HDGF PKNOX1 GLIS2 ATF7 RUNX3 SP3 SP5 SMARCA4 GLIS1 NBN

Genomic Locations for PPM1J Gene

Genomic Locations for PPM1J Gene
chr1:112,709,994-112,715,477
(GRCh38/hg38)
Size:
5,484 bases
Orientation:
Minus strand
chr1:113,252,616-113,258,099
(GRCh37/hg19)

Genomic View for PPM1J Gene

Genes around PPM1J on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1J Gene

Proteins for PPM1J Gene

  • Protein details for PPM1J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JR12-PPM1J_HUMAN
    Recommended name:
    Protein phosphatase 1J
    Protein Accession:
    Q5JR12
    Secondary Accessions:
    • B3KSB7
    • Q6DKJ7
    • Q96EZ7
    • Q9UF84

    Protein attributes for PPM1J Gene

    Size:
    505 amino acids
    Molecular mass:
    54834 Da
    Quaternary structure:
    • Interacts with UBE2I/UBC9.

    Alternative splice isoforms for PPM1J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1J Gene

Selected DME Specific Peptides for PPM1J Gene

Q5JR12:
  • NMTGWAYK
  • FTHLEFPRRV
  • EFTPETERQR
  • LGSGDDISV
  • RLPWSTGYAEVINAGKS
  • GEGKKARVMATIGVTRGLGDH
  • ANAGDSR
  • PEVRVYDL
  • RNGEIIPMS
  • NEDQACCEVV

Post-translational modifications for PPM1J Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPM1J Gene

Domains & Families for PPM1J Gene

Gene Families for PPM1J Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPM1J Gene

Suggested Antigen Peptide Sequences for PPM1J Gene

Graphical View of Domain Structure for InterPro Entry

Q5JR12

UniProtKB/Swiss-Prot:

PPM1J_HUMAN :
  • Belongs to the PP2C family.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1J: view

Function for PPM1J Gene

Molecular function for PPM1J Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for PPM1J Gene

Phenotypes From GWAS Catalog for PPM1J Gene

Gene Ontology (GO) - Molecular Function for PPM1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPM1J: view
genes like me logo Genes that share phenotypes with PPM1J: view

Animal Models for PPM1J Gene

MGI Knock Outs for PPM1J:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPM1J Gene

Localization for PPM1J Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1J gene
Compartment Confidence
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPM1J Gene

Pathways & Interactions for PPM1J Gene

genes like me logo Genes that share pathways with PPM1J: view

Pathways by source for PPM1J Gene

2 BioSystems pathways for PPM1J Gene

SIGNOR curated interactions for PPM1J Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPM1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with PPM1J: view

Drugs & Compounds for PPM1J Gene

(2) Drugs for PPM1J Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PPM1J Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PPM1J: view

Transcripts for PPM1J Gene

Unigene Clusters for PPM1J Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1J:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1J Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for PPM1J Gene

GeneLoc Exon Structure for
PPM1J
ECgene alternative splicing isoforms for
PPM1J

Expression for PPM1J Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1J Gene

This gene is overexpressed in Testis (x12.2) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for PPM1J Gene

This gene is overexpressed in Nasal epithelium (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPM1J Gene



Protein tissue co-expression partners for PPM1J Gene

NURSA nuclear receptor signaling pathways regulating expression of PPM1J Gene:

PPM1J

SOURCE GeneReport for Unigene cluster for PPM1J Gene:

Hs.655231

Evidence on tissue expression from TISSUES for PPM1J Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PPM1J: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1J Gene

Orthologs for PPM1J Gene

This gene was present in the common ancestor of animals.

Orthologs for PPM1J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1J 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia PPM1J 33 34
  • 92.08 (n)
cow
(Bos Taurus)
Mammalia PPM1J 33 34
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Ppm1j 33
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Ppm1j 33 16 34
  • 86.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1J 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1J 33 34
  • 71.21 (n)
lizard
(Anolis carolinensis)
Reptilia PPM1J 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppm1j 34
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17598 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C42C1.2 34
  • 31 (a)
OneToMany
Species where no ortholog for PPM1J was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPM1J Gene

ENSEMBL:
Gene Tree for PPM1J (if available)
TreeFam:
Gene Tree for PPM1J (if available)

Paralogs for PPM1J Gene

Paralogs for PPM1J Gene

(3) SIMAP similar genes for PPM1J Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPM1J: view

Variants for PPM1J Gene

Sequence variations from dbSNP and Humsavar for PPM1J Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000424483 -- 112,716,056(+) ACAAA(G/T)ACTAT intron-variant, upstream-variant-2KB
rs1000595945 -- 112,711,697(+) GCCTT(G/T)CAGGG intron-variant
rs1000807781 -- 112,717,122(+) ATATA(A/C)CTCCT nc-transcript-variant, upstream-variant-2KB
rs1001131509 -- 112,715,073(+) CCCGG(A/G)GCTCA upstream-variant-2KB, reference, missense
rs1001155217 -- 112,717,298(+) AGGGA(C/G)AATAA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPM1J Gene

Variant ID Type Subtype PubMed ID
nsv998794 CNV gain 25217958
nsv547566 CNV gain 21841781
esv27598 CNV loss 19812545

Variation tolerance for PPM1J Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1J Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPM1J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1J Gene

Disorders for PPM1J Gene

Relevant External Links for PPM1J

Genetic Association Database (GAD)
PPM1J
Human Genome Epidemiology (HuGE) Navigator
PPM1J
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1J

No disorders were found for PPM1J Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1J Gene

Publications for PPM1J Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. (PMID: 12633878) Kashiwaba M … Tamura S (FEBS letters 2003) 2 3 60
  4. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 60
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60

Products for PPM1J Gene

Sources for PPM1J Gene

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