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Aliases for PPM1G Gene

Aliases for PPM1G Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1G 2 3 5
  • Protein Phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform 2 3
  • Protein Phosphatase Magnesium-Dependent 1 Gamma 3 4
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G 2 3
  • Protein Phosphatase 2C Isoform Gamma 3 4
  • Protein Phosphatase 1C 3 4
  • EC 3.1.3.16 4 63
  • PP2C-Gamma 3 4
  • Protein Phosphatase 2, Catalytic Subunit, Gamma Isoform 3
  • Protein Phosphatase 2C Gamma Isoform 3
  • Protein Phosphatase 2C 2
  • Gamma Isoform 2
  • PP2C, Gamma 3
  • PP2CGAMMA 3
  • PPP2CG 3
  • Gamma 2
  • PP2CG 3
  • PPM1C 4
  • PP2C 2

External Ids for PPM1G Gene

Previous GeneCards Identifiers for PPM1G Gene

  • GC02M027525
  • GC02M027696
  • GC02M027561
  • GC02M027578
  • GC02M027516
  • GC02M027457
  • GC02M027604

Summaries for PPM1G Gene

Entrez Gene Summary for PPM1G Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPM1G Gene

PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G) is a Protein Coding gene. Among its related pathways are AMPK Enzyme Complex Pathway and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include phosphoprotein phosphatase activity and protein serine/threonine phosphatase activity.

Gene Wiki entry for PPM1G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1G Gene

Genomics for PPM1G Gene

Regulatory Elements for PPM1G Gene

Promoters for PPM1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPM1G on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPM1G gene promoter:

Genomic Location for PPM1G Gene

Chromosome:
2
Start:
27,381,194 bp from pter
End:
27,409,687 bp from pter
Size:
28,494 bases
Orientation:
Minus strand

Genomic View for PPM1G Gene

Genes around PPM1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1G Gene

Proteins for PPM1G Gene

  • Protein details for PPM1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15355-PPM1G_HUMAN
    Recommended name:
    Protein phosphatase 1G
    Protein Accession:
    O15355

    Protein attributes for PPM1G Gene

    Size:
    546 amino acids
    Molecular mass:
    59272 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with NOL3; may dephosphorylate NOL3.

neXtProt entry for PPM1G Gene

Proteomics data for PPM1G Gene at MOPED

Post-translational modifications for PPM1G Gene

  • Ubiquitination at Lys 92, Lys 209, Lys 339, Lys 358, Lys 409, and Lys 519
  • Modification sites at PhosphoSitePlus

Other Protein References for PPM1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PPM1G Gene

Gene Families for PPM1G Gene

Protein Domains for PPM1G Gene

Suggested Antigen Peptide Sequences for PPM1G Gene

Graphical View of Domain Structure for InterPro Entry

O15355

UniProtKB/Swiss-Prot:

PPM1G_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1G: view

Function for PPM1G Gene

Molecular function for PPM1G Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for PPM1G Gene

Gene Ontology (GO) - Molecular Function for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IEA,IPI 21044950
genes like me logo Genes that share ontologies with PPM1G: view
genes like me logo Genes that share phenotypes with PPM1G: view

Animal Models for PPM1G Gene

MGI Knock Outs for PPM1G:

Animal Model Products

miRNA for PPM1G Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPM1G Gene

Localization for PPM1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1G Gene

Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPM1G Gene COMPARTMENTS Subcellular localization image for PPM1G gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPM1G: view

Pathways & Interactions for PPM1G Gene

genes like me logo Genes that share pathways with PPM1G: view

Pathways by source for PPM1G Gene

1 BioSystems pathway for PPM1G Gene
1 Qiagen pathway for PPM1G Gene

Gene Ontology (GO) - Biological Process for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
genes like me logo Genes that share ontologies with PPM1G: view

No data available for SIGNOR curated interactions for PPM1G Gene

Drugs & Compounds for PPM1G Gene

(3) Drugs for PPM1G Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
calcium Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for PPM1G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPM1G: view

Transcripts for PPM1G Gene

mRNA/cDNA for PPM1G Gene

Unigene Clusters for PPM1G Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for PPM1G Gene

GeneLoc Exon Structure for
PPM1G
ECgene alternative splicing isoforms for
PPM1G

Expression for PPM1G Gene

mRNA expression in normal human tissues for PPM1G Gene

mRNA differential expression in normal tissues according to GTEx for PPM1G Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for PPM1G Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (14.6), Stomach (12.3), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PPM1G Gene



SOURCE GeneReport for Unigene cluster for PPM1G Gene Hs.643951

mRNA Expression by UniProt/SwissProt for PPM1G Gene

O15355-PPM1G_HUMAN
Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart.
genes like me logo Genes that share expression patterns with PPM1G: view

Protein tissue co-expression partners for PPM1G Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPM1G Gene

Orthologs for PPM1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1G 36
  • 100 (a)
OneToOne
PPM1G 35
  • 99.88 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PPM1G 35
  • 93.8 (n)
  • 95.4 (a)
PPM1G 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPM1G 36
  • 97 (a)
OneToOne
PPM1G 35
  • 94.61 (n)
  • 95.59 (a)
mouse
(Mus musculus)
Mammalia Ppm1g 36
  • 94 (a)
OneToOne
Ppm1g 16
Ppm1g 35
  • 91.08 (n)
  • 92.44 (a)
oppossum
(Monodelphis domestica)
Mammalia PPM1G 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1G 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1g 35
  • 91.08 (n)
  • 92.62 (a)
chicken
(Gallus gallus)
Aves PPM1G 35
  • 76.55 (n)
  • 82.65 (a)
PPM1G 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPM1G 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ppm1g-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1g 35
  • 72.86 (n)
  • 84.62 (a)
Str.6654 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3251 35
zebrafish
(Danio rerio)
Actinopterygii ppm1g 36
  • 70 (a)
OneToOne
ppm1g 35
  • 67.99 (n)
  • 72.75 (a)
wufj67a11 35
fruit fly
(Drosophila melanogaster)
Insecta CG10417 35
  • 58.43 (n)
  • 57.85 (a)
CG10417 37
  • 56 (a)
CG10417 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F42G9.1 36
  • 40 (a)
OneToOne
T23F11.1 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC4 36
  • 26 (a)
OneToMany
PTC4 38
barley
(Hordeum vulgare)
Liliopsida Hv.8837 35
rice
(Oryza sativa)
Liliopsida Os09g0558000 35
  • 57.32 (n)
  • 53.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1963 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3875 36
  • 45 (a)
OneToOne
Species with no ortholog for PPM1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1G Gene

ENSEMBL:
Gene Tree for PPM1G (if available)
TreeFam:
Gene Tree for PPM1G (if available)

Paralogs for PPM1G Gene

No data available for Paralogs for PPM1G Gene

Variants for PPM1G Gene

Sequence variations from dbSNP and Humsavar for PPM1G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1083864 -- 27,396,182(-) tgatt(C/G)tcctg intron-variant
rs1083865 -- 27,397,960(+) CAGCC(A/G)GGCAC intron-variant
rs1260324 -- 27,391,351(-) caaaa(A/G)atgag intron-variant
rs1260338 -- 27,402,794(+) agtgt(A/G)agact intron-variant
rs1270254 -- 27,391,878(-) ggcgc(A/G)tgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1G Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
dgv4072n71 CNV Loss 21882294
nsv873757 CNV Loss 21882294

Variation tolerance for PPM1G Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1G Gene

HapMap Linkage Disequilibrium report
PPM1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1G Gene

Disorders for PPM1G Gene

Relevant External Links for PPM1G

Genetic Association Database (GAD)
PPM1G
Human Genome Epidemiology (HuGE) Navigator
PPM1G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1G

No disorders were found for PPM1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1G Gene

Publications for PPM1G Gene

  1. PP2C gamma: a human protein phosphatase with a unique acidic domain. (PMID: 9276438) Travis S.M. … Welsh M.J. (FEBS Lett. 1997) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PPM1G Gene

Sources for PPM1G Gene

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