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Aliases for PPM1G Gene

Aliases for PPM1G Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1G 2 3 5
  • Protein Phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform 2 3
  • Protein Phosphatase Magnesium-Dependent 1 Gamma 3 4
  • Protein Phosphatase 2C Isoform Gamma 3 4
  • Protein Phosphatase 1C 3 4
  • EC 4 61
  • PP2C-Gamma 3 4
  • Protein Phosphatase 2, Catalytic Subunit, Gamma Isoform 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G 2
  • Protein Phosphatase 2C, Gamma Isoform 2
  • Protein Phosphatase 2C Gamma Isoform 3
  • Protein Phosphatase 1G 3
  • PP2C, Gamma 2
  • PPP2CG 3
  • PP2CG 3
  • PPM1C 4

External Ids for PPM1G Gene

Previous GeneCards Identifiers for PPM1G Gene

  • GC02M027525
  • GC02M027696
  • GC02M027561
  • GC02M027578
  • GC02M027516
  • GC02M027457
  • GC02M027604

Summaries for PPM1G Gene

Entrez Gene Summary for PPM1G Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPM1G Gene

PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G) is a Protein Coding gene. Among its related pathways are AMPK Enzyme Complex Pathway and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include phosphoprotein phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1A.

Gene Wiki entry for PPM1G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1G Gene

Genomics for PPM1G Gene

Regulatory Elements for PPM1G Gene

Enhancers for PPM1G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F026562 1.1 Ensembl ENCODE 20.5 +846.9 846872 1.3 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 NRBP1 PPM1G GTF3C2 KCNK3 HADHA OST4 C2orf70 GC02P026627
GH02F027179 1 ENCODE 12.2 +228.6 228593 3.8 ATF1 ZFP64 YY1 ZNF121 FOS ZNF202 REST PPARG ZNF623 ZNF518A CAD GTF3C2-AS1 GTF3C2 LOC105374363 GPN1 NRBP1 ATRAID PPM1G ENSG00000272148 ZNF513
GH02F027496 0.6 Ensembl ENCODE 12.2 -87.1 -87130 1.2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF416 FOS SP3 CAD GTF3C2 GPN1 LOC105374363 GTF3C2-AS1 NRBP1 PPM1G ENSG00000233438 SNX17 FNDC4
GH02F027719 1.5 FANTOM5 Ensembl ENCODE 12.1 -311.1 -311061 2.5 SIN3A GLI4 BRCA1 ZNF2 ZNF416 FOS SP3 TSHZ1 ZNF518A ZNF623 CAD GPN1 GTF3C2 LOC105374363 GTF3C2-AS1 NRBP1 ZNF512 PPM1G ENSG00000233438 SNX17
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPM1G on UCSC Golden Path with GeneCards custom track

Promoters for PPM1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PPM1G Gene

27,381,194 bp from pter
27,409,687 bp from pter
28,494 bases
Minus strand

Genomic View for PPM1G Gene

Genes around PPM1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1G Gene

Proteins for PPM1G Gene

  • Protein details for PPM1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1G
    Protein Accession:

    Protein attributes for PPM1G Gene

    546 amino acids
    Molecular mass:
    59272 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with NOL3; may dephosphorylate NOL3.

neXtProt entry for PPM1G Gene

Post-translational modifications for PPM1G Gene

  • Ubiquitination at Lys 92, Lys 209, Lys 339, Lys 358, Lys 409, and Lys 519
  • Modification sites at PhosphoSitePlus

Other Protein References for PPM1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PPM1G

Domains & Families for PPM1G Gene

Gene Families for PPM1G Gene

Protein Domains for PPM1G Gene

Suggested Antigen Peptide Sequences for PPM1G Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1G: view

Function for PPM1G Gene

Molecular function for PPM1G Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for PPM1G Gene

Gene Ontology (GO) - Molecular Function for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,IDA 20801214
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with PPM1G: view
genes like me logo Genes that share phenotypes with PPM1G: view

Animal Models for PPM1G Gene

MGI Knock Outs for PPM1G:

Animal Model Products

miRNA for PPM1G Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPM1G Gene

Localization for PPM1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1G Gene

Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for PPM1G Gene COMPARTMENTS Subcellular localization image for PPM1G gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 9271424
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPM1G: view

Pathways & Interactions for PPM1G Gene

genes like me logo Genes that share pathways with PPM1G: view

Pathways by source for PPM1G Gene

1 BioSystems pathway for PPM1G Gene
1 Qiagen pathway for PPM1G Gene

Gene Ontology (GO) - Biological Process for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 9276438
GO:0007050 cell cycle arrest IEA --
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
genes like me logo Genes that share ontologies with PPM1G: view

No data available for SIGNOR curated interactions for PPM1G Gene

Drugs & Compounds for PPM1G Gene

(5) Drugs for PPM1G Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for PPM1G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with PPM1G: view

Transcripts for PPM1G Gene

mRNA/cDNA for PPM1G Gene

Unigene Clusters for PPM1G Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1G:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP4: -

Relevant External Links for PPM1G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPM1G Gene

mRNA expression in normal human tissues for PPM1G Gene

mRNA differential expression in normal tissues according to GTEx for PPM1G Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for PPM1G Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (14.6), Stomach (12.3), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPM1G Gene

Protein tissue co-expression partners for PPM1G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1G Gene:


SOURCE GeneReport for Unigene cluster for PPM1G Gene:


mRNA Expression by UniProt/SwissProt for PPM1G Gene:

Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart.
genes like me logo Genes that share expression patterns with PPM1G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPM1G Gene

Orthologs for PPM1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPM1G 34 35
  • 99.88 (n)
(Canis familiaris)
Mammalia PPM1G 34 35
  • 94.61 (n)
(Bos Taurus)
Mammalia PPM1G 34 35
  • 93.8 (n)
(Mus musculus)
Mammalia Ppm1g 34 16 35
  • 91.08 (n)
(Rattus norvegicus)
Mammalia Ppm1g 34
  • 91.08 (n)
(Ornithorhynchus anatinus)
Mammalia PPM1G 35
  • 86 (a)
(Monodelphis domestica)
Mammalia PPM1G 35
  • 82 (a)
(Gallus gallus)
Aves PPM1G 34 35
  • 76.55 (n)
(Anolis carolinensis)
Reptilia PPM1G 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1g 34
  • 72.86 (n)
Str.6654 34
African clawed frog
(Xenopus laevis)
Amphibia ppm1g-prov 34
(Danio rerio)
Actinopterygii ppm1g 34 35
  • 67.99 (n)
wufj67a11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3251 34
fruit fly
(Drosophila melanogaster)
Insecta CG10417 36 34 35
  • 58.43 (n)
(Caenorhabditis elegans)
Secernentea T23F11.1 36
  • 47 (a)
F42G9.1 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC4 35 37
  • 26 (a)
(Oryza sativa)
Liliopsida Os09g0558000 34
  • 57.32 (n)
(Hordeum vulgare)
Liliopsida Hv.8837 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3875 35
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1963 34
Species where no ortholog for PPM1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1G Gene

Gene Tree for PPM1G (if available)
Gene Tree for PPM1G (if available)

Paralogs for PPM1G Gene

Paralogs for PPM1G Gene

genes like me logo Genes that share paralogs with PPM1G: view

Variants for PPM1G Gene

Sequence variations from dbSNP and Humsavar for PPM1G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10178379 -- 27,402,415(+) GACAA(C/T)AGAAC intron-variant
rs10221565 -- 27,394,742(+) gtctt(A/T)aaaaa intron-variant, upstream-variant-2KB
rs1045325 -- 27,381,563(-) GTTTT(C/T)TGAGC upstream-variant-2KB, utr-variant-3-prime
rs1062922 -- 27,381,587(-) TCCAG(A/C)CCCCT upstream-variant-2KB, utr-variant-3-prime
rs1083864 -- 27,396,182(-) tgatt(C/G)tcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1G Gene

Variant ID Type Subtype PubMed ID
esv3575209 CNV gain 25503493
esv3590136 CNV loss 21293372
nsv581244 CNV loss 21841781
nsv833614 CNV gain 17160897
nsv961021 CNV duplication 23825009

Variation tolerance for PPM1G Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1G Gene

Disorders for PPM1G Gene

Relevant External Links for PPM1G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPM1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1G Gene

Publications for PPM1G Gene

  1. PP2C gamma: a human protein phosphatase with a unique acidic domain. (PMID: 9276438) Travis S.M. … Welsh M.J. (FEBS Lett. 1997) 2 3 4 64
  2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64
  5. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. (PMID: 27234298) Raducu M. … D'Angiolella V. (EMBO J. 2016) 3 64

Products for PPM1G Gene

Sources for PPM1G Gene

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