Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPM1G Gene

protein-coding   GIFtS: 64
GCID: GC02M027604

protein phosphatase, Mg2+/Mn2+ dependent, 1G

(Previous names: protein phosphatase 1G (formerly 2C), magnesium-dependent,...)
 Explore 4 diseases affiliated with
PPM1G via our new
 Human Malady Compendium 
Biological research products
for PPM1G
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G1 2     PP2Cgamma1
PP2CG1 2     PP2CGAMMA2
Protein Phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform1 2     PPP2CG2
Protein Phosphatase 1C2 3     PP2C, Gamma2
Protein Phosphatase 2C Isoform Gamma2 3     Protein Phosphatase 1G2
Protein Phosphatase Magnesium-Dependent 1 Gamma2 3     Protein Phosphatase 2, Catalytic Subunit, Gamma Isoform2
PP2C-Gamma1     Protein Phosphatase 2C Gamma Isoform2
EC 3.1.3.163 8     PPM1C3

External Ids:    HGNC: 92781   Entrez Gene: 54962   Ensembl: ENSG000001152417   OMIM: 6051195   UniProtKB: O153553   

Export aliases for PPM1G gene to outside databases

Previous GC identifers: GC02M027525 GC02M027696 GC02M027561 GC02M027578 GC02M027516 GC02M027457 GC02M027346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPM1G:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members
are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for
the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome.
Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. (provided
by RefSeq, Apr 2010)

Gene Wiki entry for PPM1G


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPM1G gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPM1G promoter sequence
   Search SABiosciences Chromatin IP Primers for PPM1G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPM1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

PPM1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1G gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027604:  view genomic region     (about GC identifiers)

Start:
27,604,061 bp from pter      End:
27,632,554 bp from pter
Size:
28,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355 (See protein sequence)
Recommended Name: Protein phosphatase 1G  
Size: 546 amino acids; 59272 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Subcellular location: Cytoplasm (Potential)

Explore the universe of human proteins at neXtProt for PPM1G: NX_O15355

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15355

  • 4/12 DME Specific Peptides for PPM1G (O15355) (see all 12)
     ANAGDSR  VYDGHGG  DSEECSE  EVALYCAK 

    PPM1G Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_817092.1  
    ENSEMBL proteins: 
     ENSP00000342778   ENSP00000264714  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): PPM1G
    OriGene Protein Over-expression Lysate (see all 2): PPM1G
    OriGene Custom Protein Services for PPM1G 
    GenScript Custom Purified and Recombinant Proteins Services for PPM1G
    Novus Biologicals PPM1G Proteins
    Novus Biologicals PPM1G Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PPM1G
    Uscn Proteins for PPM1G

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008287protein serine/threonine phosphatase complex ----


    PPM1G for ontologies           About GeneDecksing



    PPM1G Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PPM1G (PP2C gamma)
    OriGene Antibodies: PPM1G
    OriGene Custom Antibody Services for PPM1G 
    GenScript Custom Superior Antibodies Services for PPM1G
    Novus Biologicals PPM1G Antibodies
    Abcam antibodies for PPM1G 
    Uscn Antibodies for PPM1G
    ThermoFisher Antibodies for PPM1G

    Assay Products for PPM1G: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Kinase Activity Assays & Reagents for PPM1G (PP2C gamma)
    GenScript Custom Assay Services for PPM1G
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PPM1G


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PPM1G for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001932 PP2C-like
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry O15355

    ProtoNet protein and cluster: O15355

    1 Blocks protein family: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355
    Similarity: Belongs to the PP2C family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): PPM1G
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPM1G
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1G:
    hsa-miR-548d-3p hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidPPM1G 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPM1G (see all 7)
    OriGene shRNA RFP: PPM1G
    OriGene siRNA: PPM1G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPM1G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPM1G

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1G (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1G (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPM1G (NM_177983)
    Sino Biological Human cDNA Clone for PPM1G
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1G 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPM1G
    Search LifeMap BioReagents cell lines for PPM1G

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1G

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IDA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--


    PPM1G for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PPM1G:
     Decreased focal adhesion (FA)   Decreased mitotic index  Increased Erk phosphorylation   Increased apoptosis 
     Increased cell death HMECs cel 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppm1g):
     mortality/aging  nervous system 

    PPM1G for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and survival BAD phosphorylation
    Apoptosis and survival BAD phosphorylation1.00
    Apoptosis and survival_BAD phosphorylation0.99
    2AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway1.00
    3mRNA Splicing - Major Pathway
    mRNA processing0.48
    4wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Regulation of CFTR activity (norm and CF)0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PPM1G
        Apoptosis and survival BAD phosphorylation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PPM1G
        AMPK Enzyme Complex Pathway

    2 GeneGo (Thomson Reuters) Pathways for PPM1G
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for PPM1G 
        mRNA processing



    PPM1G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPM1G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for PPM1G (O153551, 2, 3 ENSP000002647144) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRPAP1P305332, 3MINT-63653 I2D: score=4 
    EEF2P136392, 3MINT-8415355 I2D: score=2 
    YWHAGP619812, 3MINT-8415355 I2D: score=1 
    USP7Q930092, 3, ENSP000003435354MINT-8415355 I2D: score=2 STRING: ENSP00000343535
    RPS6KA1Q154182, 3, ENSP000003632774MINT-8269461 I2D: score=2 STRING: ENSP00000363277
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS9276438
    GO:0007050cell cycle arrest IEA--
    GO:0035970peptidyl-threonine dephosphorylation IDA--


    PPM1G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPM1G

    5 HMDB Compounds for PPM1G    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about PPM1G 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPM1G gene: 
    NM_177983.2  

    Unigene Cluster for PPM1G:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1G
    Hs.643951  [show with all ESTs]
    Unigene Representative Sequence: NM_177983
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344034(uc002rkl.3) ENST00000472077(uc002rkm.3) ENST00000484925
    ENST00000350803

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): PPM1G
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPM1G
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1G:
    hsa-miR-548d-3p hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidPPM1G 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPM1G (see all 7)
    OriGene shRNA RFP: PPM1G
    OriGene siRNA: PPM1G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPM1G
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1G (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1G (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPM1G (NM_177983)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1G 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPM1G
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPM1G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPM1G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPM1G

    Additional cDNA sequence: 

    AK127593.1 AK293141.1 AK312455.1 BC000057.2 BC007361.2 BC014386.2 BC015048.1 BC022061.2 
    BT007454.1 CR457059.1 Y13936.1 

    24/40 DOTS entries (see all 40):

    DT.100032043  DT.418362  DT.95129893  DT.100675040  DT.100675039  DT.100675044  DT.120979445  DT.120979318 
    DT.91947159  DT.100675036  DT.91950995  DT.120979471  DT.100735964  DT.100675025  DT.91778416  DT.91778423 
    DT.434682  DT.120979500  DT.437116  DT.95171505  DT.95294783  DT.100675038  DT.120979287  DT.120979392 

    24/793 AceView cDNA sequences (see all 793):

    BQ064526 CA312979 BU931649 BM699785 BQ061122 BQ423987 BQ432038 CR605593 
    BE251725 CA443786 BU509072 AL546550 AW239336 BE275719 BU178173 CF132119 
    BU164463 CD359566 BU171112 BU192707 BM707877 BQ925156 BG319602 BM550329 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPM1G    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                  -                     


    ECgene alternative splicing isoforms for PPM1G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPM1G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCTCGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PPM1G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPM1G

    SOURCE GeneReport for Unigene cluster: Hs.643951

    UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355
    Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart

        SABiosciences Expression via Pathway-Focused PCR Array including PPM1G: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPM1G
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPM1G
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPM1G
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPM1G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPM1G gene from 8/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPM1G1 protein phosphatase, Mg2+/Mn2+ dependent, 1G 76.1(n)
    81.94(a)
      421986  XM_003641050.1  XP_003641098.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPM1G6
    --
    61(a)
    1 ↔ 1
    AAWZ02038113(167-9120)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppm1g-prov2 protein phosphatase 1G (formerly 2C), magnesium-dependent, more 76.72(n)    BC041734.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj67a112 Danio rerio mRNA similar to protein phosphatase 1G more 80.18(n)    BC052132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104171 , 3 protein amino acid dephosphorylation protein
    serine/threonine more3
    CG104171
    56(a)3
    50.25(n)1
    44.55(a)1
      41F33
    354921  NM_165430.11  NP_724410.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T23F11.13
    F42G9.11
    phosphatase3
    Protein F42G9.11
    47(a)3
    51.2(n)1
    44.51(a)1
      III(4722288-4724974)3
    1752331  NM_171075.31  NP_741086.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G318601 putative protein phosphatase 2C 60 56.8(n)
    51.97(a)
      829315  NM_119336.3  NP_194914.1 
    rice
    (Oryza sativa)
    Liliopsida AK112023.12   -- 74.4(n)    AK112023.1 


    ENSEMBL Gene Tree for PPM1G (if available)
    TreeFam Gene Tree for PPM1G (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPM1G gene
    PPM1D2  PPM1A2  PPM1B2  PPM1N2  

    PPM1G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 NCBI SNPs in PPM1G are shown (see all 445    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561209171,2
    F,--27345676(+) GGGACG/ACGTAG 2 -- us2k13Minor allele frequency- A:0.17WA NA EA 358
    rs129909201,2
    C--27345801(+) GAGGCG/TTCCTG 2 -- us2k10--------
    rs130233651,2
    C,F,H--27345821(+) AGGCTT/CCAGGC 2 -- us2k14Minor allele frequency- C:0.01NS EA 418
    rs129911051,2
    C--27345898(+) GGGCAG/TCCGCG 2 -- us2k10--------
    rs1140786421,2
    C,F,--27346328(+) CCTCTT/CTGGAA 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1122347491,2
    --27346804(+) CACAAC/TGGCCC 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1123576801,2
    C--27346995(+) ACTCAG/CCTCTT 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1862443231,2
    --27604041(+) AGCAGA/GAAAAA 3 -- us2k1 ds50010--------
    rs1919521851,2
    --27604059(+) CGATGA/CGTACG 3 -- ds5001 us2k10--------
    rs1443241551,2
    --27604201(+) CAGAA-/CC    
       CCCCC
    CCGCC
    3 -- ut31 us2k10--------

    HapMap Linkage Disequilibrium report for PPM1G (27604061 - 27632554 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPM1G: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPM1G
    DNA2.0 Custom Variant and Variant Library Synthesis for PPM1G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PPM1G for disorders           About GeneDecksing

    OMIM gene information: 605119    OMIM disorders: --

    4 diseases for PPM1G:    About MalaCards
    sertoli cell-only syndrome    conduct disorder    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: PPM1G (1 document)

    Export disorders for PPM1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPM1G gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with PPM1G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PP2C gamma: a human protein phosphatase with a unique acidic domain. (PubMed id 9276438)1, 2, 3 Travis S.M. and Welsh M.J. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. ATM-dependent downregulation of USP7/HAUSP by PPM1G ac tivates p53 response to DNA damage. (PubMed id 22361354)1 Khoronenkova S.V....Dianov G.L. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5496 HGNC: 9278 AceView: PPM1G Ensembl:ENSG00000115241 euGenes: HUgn5496
    ECgene: PPM1G H-InvDB: PPM1G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPM1G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPM1G gene:
    Search GeneIP for patents involving PPM1G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PPM1G (PP2C gamma)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Kinase Activity Assays/Reagents for PPM1G (PP2C gamma)  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for PPM1G   OriGene shRNA RFP for PPM1G  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPM1G   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPM1G  
     OriGene Protein Over-expression Lysate for PPM1G   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PPM1G   OriGene 3'-UTR Clone for PPM1G  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1G   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1G  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PPM1G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPM1G   OriGene Custom Protein Services for PPM1G  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPM1G
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPM1G
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPM1G
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPM1G
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPM1G
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPM1G
     GenScript Custom Purified and Recombinant Proteins Services for PPM1G GenScript cDNA clones with any tag delivered in your preferred vector for PPM1G
     GenScript Custom Assay Services for PPM1G GenScript Custom Superior Antibodies Services for PPM1G
     GenScript Custom overexpressing Cell Line Services for PPM1G CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PPM1G promoter
     Search Chromatin IP Primers for PPM1G
     RT2 qPCR Primer Assay in human, mouse, rat PPM1G
     GNC Network for PPM1G
     SABiosciences PCR Arrays including human, mouse, rat PPM1G
     Search Tocris compounds for PPM1G
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for PPM1G
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPM1G antibodies
     PPM1G proteins
     PPM1G lysates
     Antibodies for PPM1G
     See all of Abcam's Antibodies, Kits and Proteins for PPM1G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PPM1G




     PPM1G Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PPM1G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1G
     SwitchGear 3'UTR luciferase reporter plasmids for PPM1G
     SwitchGear Promoter luciferase reporter plasmids for PPM1G
     ThermoFisher Antibodies for PPM1G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1G
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPM1G gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4