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PPM1G Gene

protein-coding   GIFtS: 67
GCID: GC02M027604

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G

(Previous names: protein phosphatase 1G (formerly 2C), magnesium-dependent,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G1 2     Protein Phosphatase 2C1
Protein Phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform1 2     PP2CG2
Protein Phosphatase 1C2 3     PP2CGAMMA2
Protein Phosphatase 2C Isoform Gamma2 3     PPP2CG2
Protein Phosphatase Magnesium-Dependent 1 Gamma2 3     PP2C, Gamma2
PP2C-gamma2 3     Protein Phosphatase 1G2
EC 3.1.3.163 8     Protein Phosphatase 2, Catalytic Subunit, Gamma Isoform2
PP2C1     Protein Phosphatase 2C Gamma Isoform2
gamma1     PPM1C3
Gamma Isoform1     

External Ids:    HGNC: 92781   Entrez Gene: 54962   Ensembl: ENSG000001152417   OMIM: 6051195   UniProtKB: O153553   

Export aliases for PPM1G gene to outside databases

Previous GC identifers: GC02M027525 GC02M027696 GC02M027561 GC02M027578 GC02M027516 GC02M027457 GC02M027346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPM1G Gene:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family
members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be
responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of
functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell
cycle progression. (provided by RefSeq, Apr 2010)

GeneCards Summary for PPM1G Gene:
PPM1G (protein phosphatase, Mg2+/Mn2+ dependent, 1G) is a protein-coding gene. Diseases associated with PPM1G include conduct disorder, and sertoli cell-only syndrome. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1D.

Gene Wiki entry for PPM1G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPM1G gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPM1G promoter sequence
   Search Chromatin IP Primers for PPM1G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPM1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

PPM1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1G gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027604:  view genomic region     (about GC identifiers)

Start:
27,604,061 bp from pter      End:
27,632,554 bp from pter
Size:
28,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355 (See protein sequence)
Recommended Name: Protein phosphatase 1G  
Size: 546 amino acids; 59272 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)

Explore the universe of human proteins at neXtProt for PPM1G: NX_O15355

Explore proteomics data for PPM1G at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys92, Lys209, Lys339, Lys358, Lys409, Lys519
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPM1G (O15355) (see all 12)
     ANAGDSR  VYDGHGG  DSEECSE  EVALYCAK 


    See PPM1G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_817092.1  
    ENSEMBL proteins: 
     ENSP00000342778   ENSP00000264714  

    PPM1G Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    3 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry O15355

    ProtoNet protein and cluster: O15355

    1 Blocks protein domain: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355
    Similarity: Belongs to the PP2C family


    PPM1G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPM1G_HUMAN, O15355
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IDA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    PPM1G for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPM1G:
     Decreased focal adhesion (FA)   Decreased mitotic index  Increased Erk phosphorylation   Increased apoptosis 
     Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppm1g):
     mortality/aging  nervous system 

    PPM1G for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPM1G
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPM1G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPM1G

    miRNA
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    miRTarBase miRNAs that target PPM1G:
    hsa-mir-155-5p (MIRT020613), hsa-mir-10a-5p (MIRT047658), hsa-mir-877-3p (MIRT037135), hsa-let-7b-5p (MIRT032202), hsa-mir-484 (MIRT041984)

    Block miRNA regulation of human, mouse, rat PPM1G using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PPM1G:
    hsa-miR-548d-3p hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidPPM1G 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PPM1G
    Predesigned siRNA for gene silencing in human, mouse, rat PPM1G

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    GenScript: all cDNA clones in your preferred vector: PPM1G (NM_177983)
    Sino Biological Human cDNA Clone for PPM1G
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1G

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPM1G_HUMAN, O15355: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    PPM1G for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPM1G About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    3Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    4AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PPM1G
        AMPK Enzyme Complex Pathway

    2 GeneGo (Thomson Reuters) Pathways for PPM1G
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for PPM1G
        mRNA processing



        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1G: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPM1G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPM1G (O153551, 2, 3 ENSP000002647144) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRPAP1P305332, 3MINT-63653 I2D: score=4 
    EEF2P136392, 3MINT-8415355 I2D: score=2 
    YWHAGP619812, 3MINT-8415355 I2D: score=1 
    USP7Q930092, 3, ENSP000003435354MINT-8415355 I2D: score=2 STRING: ENSP00000343535
    RPS6KA1Q154182, 3, ENSP000003632774MINT-8269461 I2D: score=2 STRING: ENSP00000363277
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS9276438
    GO:0007050cell cycle arrest IEA--
    GO:0035970peptidyl-threonine dephosphorylation IDA--

    PPM1G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPM1G

    5 HMDB Compounds for PPM1G    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPM1G gene: 
    NM_177983.2  

    Unigene Cluster for PPM1G:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1G
    Hs.643951  [show with all ESTs]
    Unigene Representative Sequence: NM_177983
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344034(uc002rkl.3) ENST00000472077(uc002rkm.3) ENST00000484925
    ENST00000350803
    miRNA
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    Block miRNA regulation of human, mouse, rat PPM1G using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PPM1G:
    hsa-miR-548d-3p hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidPPM1G 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PPM1G
    Predesigned siRNA for gene silencing in human, mouse, rat PPM1G
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    GenScript: all cDNA clones in your preferred vector: PPM1G (NM_177983)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1G
    Primer
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    OriGene qPCR primer pairs and template standards for PPM1G
    OriGene qSTAR qPCR primer pairs in human, mouse for PPM1G
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPM1G
      QuantiTect SYBR Green Assays in human, mouse, rat PPM1G
      QuantiFast Probe-based Assays in human, mouse, rat PPM1G

    Additional mRNA sequence: 

    AK127593.1 AK293141.1 AK312455.1 BC000057.2 BC007361.2 BC014386.2 BC015048.1 BC022061.2 
    BT007454.1 CR457059.1 Y13936.1 

    Selected DOTS entries (see all 40):

    DT.100032043  DT.418362  DT.95129893  DT.100675040  DT.100675039  DT.100675044  DT.120979445  DT.120979318 
    DT.91947159  DT.100675036  DT.91950995  DT.120979471  DT.100735964  DT.100675025  DT.91778416  DT.91778423 
    DT.434682  DT.437116  DT.95171505  DT.95294783  DT.100675038  DT.120979392  DT.120979489  DT.120979500 

    Selected AceView cDNA sequences (see all 793):

    BI030643 BM557753 BQ061122 BQ647509 BQ932437 AU099345 BF035143 BX421364 
    BQ896828 BQ651874 AI370399 CB108781 BU171112 CB139002 BQ949423 AL546550 
    BF513765 AA383664 BP343321 BP356080 BU178173 AL045879 BF477892 CR609632 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPM1G    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                  -                     


    ECgene alternative splicing isoforms for PPM1G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPM1G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTCGGCC
    PPM1G Expression
    About this image


    PPM1G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PPM1G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPM1G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643951

    UniProtKB/Swiss-Prot: PPM1G_HUMAN, O15355
    Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1G: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPM1G
    OriGene qSTAR qPCR primer pairs in human, mouse for PPM1G
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPM1G
    QuantiTect SYBR Green Assays in human, mouse, rat PPM1G
    QuantiFast Probe-based Assays in human, mouse, rat PPM1G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPM1G gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppm1g1 , 5 protein phosphatase 1G (formerly 2C), magnesium-dependent, more1, 5 91.08(n)1
    92.44(a)1
      5 (17.27 cM)5
    142081  NM_008014.31  NP_032040.11 
     312026685 
    chicken
    (Gallus gallus)
    Aves PPM1G1 protein phosphatase, Mg2+/Mn2+ dependent, 1G 76.55(n)
    82.65(a)
      421986  XM_003641050.2  XP_003641098.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPM1G6
    protein phosphatase, Mg2+/Mn2+ dependent, 1G
    60(a)
    1 ↔ 1
    AAWZ02038350(7481-9862)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppm1g-prov2 protein phosphatase 1G (formerly 2C), magnesium-dependent, more 76.72(n)    BC041734.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj67a112 Danio rerio mRNA similar to protein phosphatase 1G more 80.18(n)    BC052132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104171 , 3 protein amino acid dephosphorylation
    protein serine/threonine more3
    CG104171
    56(a)3
    58.43(n)1
    57.85(a)1
      41F33
    354921  NM_136325.31  NP_610169.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T23F11.13 phosphatase 47(a)   III(4722288-4724974)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTC4(YBR125C)4 Cytoplasmic type 2C protein phosphatase (PP2C); identified more   --   2(488380-487199) 852422  NP_009683.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CF513039.12   -- 68.23(n)    CF513039.1 
    rice
    (Oryza sativa)
    Liliopsida AK112023.12   -- 74.4(n)    AK112023.1 


    ENSEMBL Gene Tree for PPM1G (if available)
    TreeFam Gene Tree for PPM1G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPM1G gene
    PPM1D2  

    PPM1G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPM1G (see all 512)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484636561,2
    C--27605676(+) GGTCT-/TTTTA 
            
    TTTTA
    1 -- int10--------
    rs355514681,2
    C--27605696(+) TTTTTT/-GAGAC 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs1873179151,2
    --27605715(+) GAGACA/GGAGTT 1 -- int10--------
    rs3729716941,2
    C--27605756(+) GGCACA/GTCTCG 1 -- int10--------
    rs343418291,2
    C,F--27605762(+) ATCTCA/GGCTCA 1 -- int14Minor allele frequency- G:0.38NA CSA 8
    rs1469069601,2
    C--27605795(+) TCAAGC/TGGTTC 1 -- int10--------
    rs74231041,2
    C,F,A--27605983(+) CAGGCA/GTGAGC 1 -- int17Minor allele frequency- G:0.29NA WA CSA 14
    rs1919480321,2
    --27606043(+) AGATGA/GGTATA 1 -- int10--------
    rs1490068571,2
    --27606061(+) CTATGC/TATAAT 1 -- int10--------
    rs23846291,2
    C,F,H--27606098(+) CACAGG/AAATAT 1 -- int119Minor allele frequency- A:0.02NS EA WA NA CSA 1155

    HapMap Linkage Disequilibrium report for PPM1G (27604061 - 27632554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPM1G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873754CNV Loss21882294
    dgv4072n71CNV Loss21882294
    nsv873757CNV Loss21882294
    nsv833614CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PPM1G
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605119    OMIM disorders: --

    10 diseases for PPM1G:    
    About MalaCards
    conduct disorder    sertoli cell-only syndrome    alcohol dependence    tonsillitis
    thyroiditis    malaria    cerebritis    neuronitis
    endotheliitis    prostatitis


    PPM1G for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPM1G
    Human Genome Epidemiology (HuGE) Navigator: PPM1G (1 document)

    Export disorders for PPM1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPM1G gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with PPM1G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PP2C gamma: a human protein phosphatase with a unique acidic domain. (PubMed id 9276438)1, 2, 3 Travis S.M. and Welsh M.J. (FEBS Lett. 1997)
    2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    5. Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. (PubMed id 23281010)1 Li X....Kapoor T.M. (Protein Sci. 2013)
    6. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    7. Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1). (PubMed id 23814053)1 Liu J....Gao T. (J. Biol. Chem. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5496 HGNC: 9278 AceView: PPM1G Ensembl:ENSG00000115241 euGenes: HUgn5496
    ECgene: PPM1G H-InvDB: PPM1G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPM1G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPM1G gene:
    Search GeneIP for patents involving PPM1G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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