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Aliases for PPM1G Gene

Aliases for PPM1G Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G 2 3
  • Protein Phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform 2 3
  • Protein Phosphatase Magnesium-Dependent 1 Gamma 3 4
  • Protein Phosphatase 2C Isoform Gamma 3 4
  • Protein Phosphatase 1C 3 4
  • EC 4 63
  • PP2C-Gamma 3 4
  • Protein Phosphatase 2, Catalytic Subunit, Gamma Isoform 3
  • Protein Phosphatase 2C Gamma Isoform 3
  • Protein Phosphatase 2C 2
  • Protein Phosphatase 1G 3
  • Gamma Isoform 2
  • PP2C, Gamma 3
  • PPP2CG 3
  • Gamma 2
  • PP2CG 3
  • PPM1C 4
  • PP2C 2

External Ids for PPM1G Gene

Previous GeneCards Identifiers for PPM1G Gene

  • GC02M027525
  • GC02M027696
  • GC02M027561
  • GC02M027578
  • GC02M027516
  • GC02M027457
  • GC02M027604

Summaries for PPM1G Gene

Entrez Gene Summary for PPM1G Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPM1G Gene

PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G) is a Protein Coding gene. Among its related pathways are AMPK Enzyme Complex Pathway and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1D.

Gene Wiki entry for PPM1G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1G Gene

Genomics for PPM1G Gene

Regulatory Elements for PPM1G Gene

Transcription factor binding sites by QIAGEN in the PPM1G gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPM1G Gene

27,381,194 bp from pter
27,409,687 bp from pter
28,494 bases
Minus strand

Genomic View for PPM1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPM1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1G Gene

Proteins for PPM1G Gene

  • Protein details for PPM1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1G
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PPM1G Gene

    546 amino acids
    Molecular mass:
    59272 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Interacts with NOL3; may dephosphorylate NOL3.

neXtProt entry for PPM1G Gene

Proteomics data for PPM1G Gene at MOPED

Post-translational modifications for PPM1G Gene

  • Ubiquitination at Lys92, Lys209, Lys339, Lys358, Lys409, and Lys519
  • Modification sites at PhosphoSitePlus

Other Protein References for PPM1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PPM1G Gene

Gene Families for PPM1G Gene

Protein Domains for PPM1G Gene

Suggested Antigen Peptide Sequences for PPM1G Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1G: view

Function for PPM1G Gene

Molecular function for PPM1G Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

Enzyme Numbers (IUBMB) for PPM1G Gene

Gene Ontology (GO) - Molecular Function for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity IDA 20801214
GO:0005515 protein binding IPI 22190034
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPM1G: view
genes like me logo Genes that share phenotypes with PPM1G: view

Animal Model Products

miRNA for PPM1G Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1G

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPM1G Gene

Localization for PPM1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1G Gene


Subcellular locations from

Jensen Localization Image for PPM1G Gene COMPARTMENTS Subcellular localization image for PPM1G gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9271424
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPM1G: view

Pathways for PPM1G Gene

genes like me logo Genes that share pathways with PPM1G: view

Pathways by source for PPM1G Gene

1 Qiagen pathway for PPM1G Gene
1 BioSystems pathway for PPM1G Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPM1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 9276438
GO:0007050 cell cycle arrest IEA --
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
genes like me logo Genes that share ontologies with PPM1G: view

Drugs for PPM1G Gene

(6) HMDB Compounds for PPM1G Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Magnesium
  • Manganese
  • NFB Orthophosphate
Phosphoric acid
  • Acide phosphorique (FRENCH)
genes like me logo Genes that share compounds with PPM1G: view

Transcripts for PPM1G Gene

mRNA/cDNA for PPM1G Gene

Unigene Clusters for PPM1G Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1G:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP4: -

Relevant External Links for PPM1G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPM1G Gene

mRNA expression in normal human tissues for PPM1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1G Gene

This gene is overexpressed in Testis (4.9).

Protein differential expression in normal tissues for PPM1G Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (14.6), Stomach (12.3), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PPM1G Gene

SOURCE GeneReport for Unigene cluster for PPM1G Gene Hs.643951

mRNA Expression by UniProt/SwissProt for PPM1G Gene

Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart
genes like me logo Genes that share expressions with PPM1G: view

Expression partners for PPM1G Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for PPM1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPM1G 35
  • 93.8 (n)
  • 95.4 (a)
PPM1G 36
  • 96 (a)
(Canis familiaris)
Mammalia PPM1G 35
  • 94.61 (n)
  • 95.59 (a)
PPM1G 36
  • 97 (a)
(Mus musculus)
Mammalia Ppm1g 35
  • 91.08 (n)
  • 92.44 (a)
Ppm1g 16
Ppm1g 36
  • 94 (a)
(Pan troglodytes)
Mammalia PPM1G 35
  • 99.88 (n)
  • 100 (a)
PPM1G 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppm1g 35
  • 91.08 (n)
  • 92.62 (a)
(Monodelphis domestica)
Mammalia PPM1G 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PPM1G 36
  • 86 (a)
(Gallus gallus)
Aves PPM1G 35
  • 76.55 (n)
  • 82.65 (a)
PPM1G 36
  • 77 (a)
(Anolis carolinensis)
Reptilia PPM1G 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1g 35
  • 72.86 (n)
  • 84.62 (a)
Str.6654 35
African clawed frog
(Xenopus laevis)
Amphibia ppm1g-prov 35
(Danio rerio)
Actinopterygii ppm1g 35
  • 67.99 (n)
  • 72.75 (a)
wufj67a11 35
ppm1g 36
  • 70 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3251 35
fruit fly
(Drosophila melanogaster)
Insecta CG10417 37
  • 56 (a)
CG10417 35
  • 58.43 (n)
  • 57.85 (a)
CG10417 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T23F11.1 37
  • 47 (a)
F42G9.1 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC4 36
  • 26 (a)
PTC4 38
(Hordeum vulgare)
Liliopsida Hv.8837 35
(Oryza sativa)
Liliopsida Os09g0558000 35
  • 57.32 (n)
  • 53.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1963 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3875 36
  • 45 (a)
Species with no ortholog for PPM1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1G Gene

Gene Tree for PPM1G (if available)
Gene Tree for PPM1G (if available)

Paralogs for PPM1G Gene

Paralogs for PPM1G Gene

genes like me logo Genes that share paralogs with PPM1G: view

Variants for PPM1G Gene

Sequence variations from dbSNP and Humsavar for PPM1G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs780097 -- 27,399,938(+) atcac(G/T)attta intron-variant
rs780098 -- 27,400,316(+) agaat(C/T)gcttt intron-variant
rs780099 -- 27,400,803(+) TCCTG(A/G)TTACA intron-variant
rs1083864 -- 27,396,182(-) tgatt(C/G)tcctg intron-variant
rs1083865 -- 27,397,960(+) CAGCC(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1G Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
dgv4072n71 CNV Loss 21882294
nsv873757 CNV Loss 21882294

Relevant External Links for PPM1G Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1G Gene

Disorders for PPM1G Gene

Relevant External Links for PPM1G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PPM1G Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PPM1G Gene

Publications for PPM1G Gene

  1. PP2C gamma: a human protein phosphatase with a unique acidic domain. (PMID: 9276438) Travis S.M. … Welsh M.J. (FEBS Lett. 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  4. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. (PMID: 20801214) Voss M. … Cohen P.T. (Cell. Signal. 2011) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for PPM1G Gene

Sources for PPM1G Gene

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