Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PPM1F Gene

protein-coding   GIFtS: 62
GCID: GC22M022273

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1F

(Previous name: protein phosphatase 1F (PP2C domain containing))
  Search for PPM1F
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1F1 2     CAMKP2
Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase1 2 3     FEM-22
Partner Of PIX 21 2 3     hFEM-22
Protein Phosphatase 1F (PP2C Domain Containing)1 2     PP2C Phosphatase2
Protein Fem-2 Homolog2 3     Protein Phosphatase 1F2
CaMKPase2 3     EC 3.1.3.163
POPX22 3     KIAA00153
CaM-Kinase Phosphatase2 3     hFem-23

External Ids:    HGNC: 193881   Entrez Gene: 96472   Ensembl: ENSG000001000347   UniProtKB: P495933   

Export aliases for PPM1F gene to outside databases

Previous GC identifers: GC22M018973 GC22M020598 GC22M005230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PPM1F Gene:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family
members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with
Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a
protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein
kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of
this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced
transcript variant has been identified, but its full-length nature has not been determined. (provided by RefSeq,
Jul 2008)

GeneCards Summary for PPM1F Gene:
PPM1F (protein phosphatase, Mg2+/Mn2+ dependent, 1F) is a protein-coding gene. GO annotations related to this gene include calmodulin-dependent protein phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1K.

UniProtKB/Swiss-Prot: PPM1F_HUMAN, P49593
Function: Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and
CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis

Gene Wiki entry for PPM1F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPM1F gene promoter:
         Elk-1   p53   Pax-2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPM1F promoter sequence
   Search Chromatin IP Primers for PPM1F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPM1F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.22

PPM1F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1F gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M022273:  view genomic region     (about GC identifiers)

Start:
22,273,792 bp from pter      End:
22,307,250 bp from pter
Size:
33,459 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PPM1F_HUMAN, P49593 (See protein sequence)
Recommended Name: Protein phosphatase 1F  
Size: 454 amino acids; 49831 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Subunit: Associates with FEM1B
Sequence caution: Sequence=BAA02803.2; Type=Erroneous initiation;
Secondary accessions: A8K6G3 Q96PM2

Explore the universe of human proteins at neXtProt for PPM1F: NX_P49593

Explore proteomics data for PPM1F at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys334
  • Modification sites at PhosphoSitePlus

  • See PPM1F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055449.1  
    ENSEMBL proteins: 
     ENSP00000263212   ENSP00000384930   ENSP00000380632   ENSP00000392372   ENSP00000388350  
     ENSP00000439915  

    PPM1F Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PPM1F Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPM1F
    OriGene Protein Over-expression Lysate for PPM1F
    OriGene MassSpec for PPM1F
    OriGene Custom Protein Services for PPM1F
    GenScript Custom Purified and Recombinant Proteins Services for PPM1F
    Novus Biologicals PPM1F Proteins
    Novus Biologicals PPM1F Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPM1F
    Cloud-Clone Corp. Proteins for PPM1F

     
    Search eBioscience for Proteins for PPM1F 

    PPM1F Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PPM1F
    OriGene Custom Antibody Services for PPM1F
    Novus Biologicals PPM1F Antibodies
    Abcam antibodies for PPM1F
    Cloud-Clone Corp. Antibodies for PPM1F
    ThermoFisher Antibodies for PPM1F
    LSBio Antibodies in human, mouse, rat for PPM1F

    PPM1F Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPM1F
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPM1F
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPM1F
    Cloud-Clone Corp. CLIAs for PPM1F
    Search eBioscience for ELISAs for PPM1F 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    3 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry P49593

    ProtoNet protein and cluster: P49593

    1 Blocks protein domain: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: PPM1F_HUMAN, P49593
    Similarity: Belongs to the PP2C family


    Find genes that share domains with PPM1F           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPM1F_HUMAN, P49593
    Function: Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and
    CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.161

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004722protein serine/threonine phosphatase activity IMP--
    GO:0005515protein binding IPI11559703
    GO:0016301kinase activity ----
    GO:0016791phosphatase activity IDA15140879
         
    Find genes that share ontologies with PPM1F           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPM1F:
     Increased Erk phosphorylation  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppm1f):
     behavior/neurological  integument  mortality/aging 

    Find genes that share phenotypes with PPM1F           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPM1F
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPM1F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPM1F
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPM1F

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPM1F:
    hsa-mir-324-5p (MIRT043063), rno-mir-200c-3p (MIRT006619), hsa-mir-186-5p (MIRT045175), hsa-mir-24-3p (MIRT030441)

    Block miRNA regulation of human, mouse, rat PPM1F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPM1F (see all 36):
    hsa-miR-21* hsa-miR-429 hsa-miR-3653 hsa-miR-124 hsa-miR-9 hsa-miR-3658 hsa-miR-149 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPPM1F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPM1F
    Predesigned siRNA for gene silencing in human, mouse, rat PPM1F

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPM1F

    Clone
    Products:
         
    OriGene clones in human, mouse for PPM1F (see all 8)
    OriGene ORF clones in mouse, rat for PPM1F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPM1F (NM_014634)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1F

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPM1F
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPM1F 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA11559703
    GO:0043234protein complex IDA11864573
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with PPM1F           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PPM1F About    
    See pathways by source

    SuperPathContained pathways About
    1Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    2Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for PPM1F
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)


        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1F: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPM1F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPM1F (P495931, 2, 3 ENSP000002632124) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARSP561922, 3, ENSP000002620274MINT-63901 I2D: score=4 STRING: ENSP00000262027
    PAK1Q131532, 3, ENSP000002785684MINT-8291050 I2D: score=3 STRING: ENSP00000278568
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-8215492 I2D: score=1 STRING: ENSP00000381412
    FEM1BQ9UK731, 2, 3, ENSP000003072984EBI-719945,EBI-310482 MINT-8215474 MINT-8215483 I2D: score=1 STRING: ENSP00000307298
    PAK2Q131772, 3, ENSP000003140674MINT-8291060 I2D: score=1 STRING: ENSP00000314067
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IDA11864573
    GO:0006470protein dephosphorylation ----
    GO:0010628positive regulation of gene expression IMP--
    GO:0010634positive regulation of epithelial cell migration IMP--
    GO:0010811positive regulation of cell-substrate adhesion IMP--

    Find genes that share ontologies with PPM1F           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPM1F

    5 HMDB Compounds for PPM1F    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for PPM1F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 49.5 2 11864573 (2)
    serine 36.5 2 11864573 (2)



    Find genes that share compounds with PPM1F           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PPM1F gene: 
    NM_014634.3  

    Unigene Cluster for PPM1F:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1F
    Hs.112728  [show with all ESTs]
    Unigene Representative Sequence: AK126377
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263212(uc002zvp.2) ENST00000407142(uc011aik.2) ENST00000496143
    ENST00000484588 ENST00000397495(uc002zvq.3) ENST00000445205 ENST00000424647
    ENST00000486259 ENST00000497072 ENST00000538191
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPM1F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPM1F (see all 36):
    hsa-miR-21* hsa-miR-429 hsa-miR-3653 hsa-miR-124 hsa-miR-9 hsa-miR-3658 hsa-miR-149 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPPM1F 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPM1F
    Predesigned siRNA for gene silencing in human, mouse, rat PPM1F
    Clone
    Products:
         
    OriGene clones in human, mouse for PPM1F (see all 8)
    OriGene ORF clones in mouse, rat for PPM1F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPM1F (NM_014634)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1F
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPM1F
    OriGene qSTAR qPCR primer pairs in human, mouse for PPM1F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPM1F
      QuantiTect SYBR Green Assays in human, mouse, rat PPM1F
      QuantiFast Probe-based Assays in human, mouse, rat PPM1F

    Additional mRNA sequence: 

    AF305840.1 AF520615.1 AK126377.1 AK291628.1 AK294557.1 BC071989.1 BC105599.1 D13640.1 

    11 DOTS entries:

    DT.217645  DT.100706797  DT.100807584  DT.91641365  DT.100698108  DT.95192319  DT.100719568  DT.100807579 
    DT.120663812  DT.120663813  DT.86857113 

    Selected AceView cDNA sequences (see all 258):

    AI758897 CA314749 CB124457 AI365161 BU683569 BC013798 AA044883 CR601797 
    BQ050662 BQ421534 BM471979 D13640 CB126771 BQ027595 AU076465 BF792106 
    AU103019 BC071989 CA391997 AW612452 BI962620 AA768718 AF520615 CA425300 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPM1F (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                    -                 -     -     -     -     -                                   -           -                     
    SP2:                                                              -                                   -           -                     
    SP3:                                      -     -     -     -     -                                   -                                 
    SP4:                                      -     -     -     -     -                                                                     
    SP5:              -     -                 -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for PPM1F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PPM1F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAAGTGTC
    PPM1F Expression
    About this image

    PPM1F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPM1F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112728
        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1F: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPM1F
    OriGene qSTAR qPCR primer pairs in human, mouse for PPM1F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPM1F
    QuantiTect SYBR Green Assays in human, mouse, rat PPM1F
    QuantiFast Probe-based Assays in human, mouse, rat PPM1F
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPM1F gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppm1f1 , 5 protein phosphatase 1F (PP2C domain containing)1, 5 82.96(n)1
    79.73(a)1
      16 (10.48 cM)5
    686061  NM_176833.41  NP_789803.11 
     168964695 
    chicken
    (Gallus gallus)
    Aves PPM1F1 protein phosphatase, Mg2+/Mn2+ dependent, 1F 63.1(n)
    62.69(a)
      416772  XM_415067.4  XP_415067.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPM1F6
    protein phosphatase, Mg2+/Mn2+ dependent, 1F
    50(a)
    1 ↔ 1
    GL343282.1(1263283-1283441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppm1f1 protein phosphatase, Mg2+/Mn2+ dependent, 1F 59.77(n)
    58.06(a)
      100380003  XM_002931884.2  XP_002931930.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppm1f1 protein phosphatase 1F (PP2C domain containing) 55.94(n)
    53.87(a)
      553757  NM_001018155.1  NP_001018165.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103761 CG10376 49.42(n)
    40.86(a)
      35126  NM_136055.2  NP_609899.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fem-26
    Protein FEM-2 (fem-2) mRNA, complete cds
    22(a)
    1 → many
    III(632024-634626) WBGene00001412
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTC16
    Type 2C protein phosphatase (PP2C); dephosphorylat...
    32(a)
    1 → many
    IV(439909-440754) YDL006W
    rice
    (Oryza sativa)
    Liliopsida Os06g05268001 Os06g0526800 48.79(n)
    42.46(a)
      4341188  NM_001064301.1  NP_001057766.1 


    ENSEMBL Gene Tree for PPM1F (if available)
    TreeFam Gene Tree for PPM1F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PPM1F gene
    PPM1K2  PPM1L2  PPM1E2  ILKAP2  
    3 SIMAP similar genes for PPM1F using alignment to 8 protein entries:     PPM1F_HUMAN (see all proteins):
    PPM1E    ILKAP    PPM1N

    Find genes that share paralogs with PPM1F           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PPM1F (see all 630)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365204
    A colorectal cancer sample4--see VAR_0365202 R Q mis40--------
    VAR_0365214
    A breast cancer sample4--see VAR_0365212 Q K mis40--------
    rs1829994881,2
    --22273372(+) TGTGCA/GCCACC 1 -- ds50010--------
    rs1475900321,2
    C--22273373(+) GTGCG-/CCACCACA 1 -- ds50010--------
    rs1878849131,2
    --22273528(+) CCCCAA/GTGTCA 1 -- ds50010--------
    rs622374811,2
    C--22273534(+) TGTCAT/CGTGAG 1 -- ds50014Minor allele frequency- C:0.10NA WA EA 360
    rs1501386751,2
    C--22273768(+) GAAGT-/CAGG  
     AAGAAGG
    CAGGA
    1 -- ds50010--------
    rs1921782011,2
    --22273967(+) CGAGAA/C/TGAACG 2 -- ut310--------
    rs1139082211,2
    C--22273971(+) ACGAAC/TGCAGA 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1160214471,2
    C,F--22274005(+) TGCACC/TGGAAT 1 -- ut311Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for PPM1F (22273792 - 22307250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPM1F (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422476CNV Deletion17116639
    dgv22e196CNV Deletion17116639
    dgv23e196CNV Deletion17116639
    esv2422338CNV Deletion17116639
    esv2422374CNV Duplication17116639
    dgv20e196CNV Duplication17116639
    nsv3566CNV Insertion18451855
    dgv4884n71CNV Loss21882294
    nsv914473CNV Loss21882294
    nsv828966CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPM1F
    DNA2.0 Custom Variant and Variant Library Synthesis for PPM1F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with PPM1F           About GenesLikeMe

    Genetic Association Database (GAD): PPM1F
    Human Genome Epidemiology (HuGE) Navigator: PPM1F (2 documents)

    Export disorders for PPM1F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PPM1F gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with PPM1F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PubMed id 11559703)1, 2, 3, 9 Tan K.M.L.... Yu V.C. (J. Biol. Chem. 2001)
    2. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (PubMed id 11864573)1, 2, 3, 9 Koh C.-G.... Lim L. (Curr. Biol. 2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    5. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    6. Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts. (PubMed id 15140879)1, 9 Harvey B.P....Ozer H.L. (J. Biol. Chem. 2004)
    7. Integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase. (PubMed id 23621870)1 Zhang S....Koh C.G. (J. Proteome Res. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP) by oxidation/reduction at Cys-359. (PubMed id 22743349)1 Baba H....Kameshita I. (Arch. Biochem. Biophys. 2012)
    10. MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. (PubMed id 22144583)1 Jurmeister S....Sahin A.9. (Mol. Cell. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9647 HGNC: 19388 AceView: PPM1F Ensembl:ENSG00000100034 euGenes: HUgn9647
    ECgene: PPM1F H-InvDB: PPM1F

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0015

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PPM1F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PPM1F gene:
    Search GeneIP for patents involving PPM1F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore Purified and/or Recombinant PPM1F Protein
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPM1F   OriGene RNAi products in human, mouse, rat for PPM1F  
     OriGene qPCR primer pairs and template standards for PPM1F   OriGene Protein Over-expression Lysate for PPM1F  
     OriGene MassSpec something-or-other for PPM1F   OriGene clones in human, mouse for PPM1F  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPM1F   OriGene Purified Protein for PPM1F  
     OriGene ORF clones in mouse, rat for PPM1F   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPM1F   OriGene Custom Protein Services for PPM1F  

     
     
     Block miRNA regulation of human, mouse, rat PPM1F using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPM1F
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPM1F Predesigned siRNA for gene silencing in human, mouse, rat PPM1F
     QuantiFast Probe-based Assays in human, mouse, rat PPM1F QuantiTect SYBR Green Assays in human, mouse, rat PPM1F
     PCR Arrays including human, mouse, rat PPM1F Search Chromatin IP Primers for PPM1F
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPM1F  GeneGlobe Interaction Network for PPM1F
     Regulatory tfbs in PPM1F promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPM1F GenScript cDNA clones with any tag delivered in your preferred vector for PPM1F
     GenScript Custom Assay Services for PPM1F GenScript Custom overexpressing Cell Line Services for PPM1F
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PPM1F
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPM1F antibodies
     PPM1F proteins
     PPM1F lysates
     Antibodies for PPM1F
     See all of Abcam's Antibodies, Kits and Proteins for PPM1F
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PPM1F
     Proteins for PPM1F
     Antibodies for PPM1F
     ELISAs for PPM1F
     CLIAs for PPM1F



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPM1F
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1F
     SwitchGear 3'UTR luciferase reporter plasmids for PPM1F
     SwitchGear Promoter luciferase reporter plasmids for PPM1F
     ThermoFisher Antibodies for PPM1F
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1F
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPM1F
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPM1F
     LSBio Antibodies in human, mouse, rat for PPM1F
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PPM1F
      Search eBioscience for proteins for PPM1F
      Search eBioscience for elisas for PPM1F
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPM1F gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4