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Aliases for PPM1F Gene

Aliases for PPM1F Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1F 2 3
  • Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase 2 3 4
  • Partner Of PIX 2 2 3 4
  • Protein Phosphatase 1F (PP2C Domain Containing) 2 3
  • CaM-Kinase Phosphatase 3 4
  • Protein Fem-2 Homolog 3 4
  • CaMKPase 3 4
  • HFEM-2 3 4
  • POPX2 3 4
  • Protein Phosphatase 1F 3
  • PP2C Phosphatase 3
  • EC 4
  • KIAA0015 4
  • CAMKP 3
  • FEM-2 3

External Ids for PPM1F Gene

Previous GeneCards Identifiers for PPM1F Gene

  • GC22M018973
  • GC22M020598
  • GC22M022273
  • GC22M005230

Summaries for PPM1F Gene

Entrez Gene Summary for PPM1F Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1F Gene

PPM1F (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1F) is a Protein Coding gene. Among its related pathways are Regulation of CFTR activity (norm and CF) and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include protein serine/threonine phosphatase activity and calmodulin-dependent protein phosphatase activity. An important paralog of this gene is PPM1E.

UniProtKB/Swiss-Prot for PPM1F Gene

  • Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis

Gene Wiki entry for PPM1F Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1F Gene

Genomics for PPM1F Gene

Regulatory Elements for PPM1F Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPM1F Gene

21,919,419 bp from pter
21,952,878 bp from pter
33,460 bases
Minus strand

Genomic View for PPM1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPM1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1F Gene

Proteins for PPM1F Gene

  • Protein details for PPM1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1F
    Protein Accession:
    Secondary Accessions:
    • A8K6G3
    • B7Z2C3
    • Q96PM2

    Protein attributes for PPM1F Gene

    454 amino acids
    Molecular mass:
    49831 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Associates with FEM1B
    • Sequence=BAA02803.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPM1F Gene


neXtProt entry for PPM1F Gene

Proteomics data for PPM1F Gene at MOPED

Post-translational modifications for PPM1F Gene

  • Ubiquitination at Lys334
  • Modification sites at PhosphoSitePlus

Other Protein References for PPM1F Gene

Antibody Products

No data available for DME Specific Peptides for PPM1F Gene

Domains for PPM1F Gene

Gene Families for PPM1F Gene

Protein Domains for PPM1F Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1F: view

Function for PPM1F Gene

Molecular function for PPM1F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis

Enzyme Numbers (IUBMB) for PPM1F Gene

Gene Ontology (GO) - Molecular Function for PPM1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004722 protein serine/threonine phosphatase activity IMP 20016286
GO:0005515 protein binding IPI 11559703
GO:0016791 phosphatase activity IDA 15140879
GO:0033192 calmodulin-dependent protein phosphatase activity IDA 11559703
genes like me logo Genes that share ontologies with PPM1F: view

Phenotypes for PPM1F Gene

genes like me logo Genes that share phenotypes with PPM1F: view

Animal Model Products

miRNA for PPM1F Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1F

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPM1F Gene

Localization for PPM1F Gene

Subcellular locations from

Jensen Localization Image for PPM1F Gene COMPARTMENTS Subcellular localization image for PPM1F gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPM1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 11559703
GO:0043234 protein complex IDA 11864573
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PPM1F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPM1F Gene

Pathways for PPM1F Gene

genes like me logo Genes that share pathways with PPM1F: view

Pathways by source for PPM1F Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPM1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 11864573
GO:0006470 protein dephosphorylation --
GO:0010628 positive regulation of gene expression IMP 20016286
GO:0010634 positive regulation of epithelial cell migration IMP 20016286
GO:0010811 positive regulation of cell-substrate adhesion IMP 20016286
genes like me logo Genes that share ontologies with PPM1F: view

Drugs for PPM1F Gene

(6) HMDB Compounds for PPM1F Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Magnesium
  • Manganese
  • NFB Orthophosphate
Phosphoric acid
  • Acide phosphorique (FRENCH)

(2) Novoseek inferred chemical compound relationships for PPM1F Gene

Compound -log(P) Hits PubMed IDs
threonine 49.5 2
serine 36.5 2
genes like me logo Genes that share compounds with PPM1F: view

Transcripts for PPM1F Gene

Unigene Clusters for PPM1F Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1F:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8: -

Relevant External Links for PPM1F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPM1F Gene

mRNA expression in normal human tissues for PPM1F Gene

mRNA differential expression in normal tissues according to GTEx for PPM1F Gene

This gene is overexpressed in Whole Blood (6.7).

Protein differential expression in normal tissues for PPM1F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3) and Lymph node (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPM1F Gene

SOURCE GeneReport for Unigene cluster for PPM1F Gene Hs.112728

genes like me logo Genes that share expressions with PPM1F: view

Expression partners for PPM1F Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PPM1F Gene

Orthologs for PPM1F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPM1F 35
  • 80.54 (n)
  • 81.58 (a)
PPM1F 36
  • 81 (a)
(Canis familiaris)
Mammalia PPM1F 35
  • 84.62 (n)
  • 84.32 (a)
PPM1F 36
  • 80 (a)
(Mus musculus)
Mammalia Ppm1f 35
  • 82.96 (n)
  • 79.73 (a)
Ppm1f 16
Ppm1f 36
  • 79 (a)
(Pan troglodytes)
Mammalia PPM1F 35
  • 99.41 (n)
  • 99.12 (a)
PPM1F 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ppm1f 35
  • 82.52 (n)
  • 79.11 (a)
(Monodelphis domestica)
Mammalia PPM1F 36
  • 58 (a)
(Gallus gallus)
Aves PPM1F 35
  • 63.1 (n)
  • 62.69 (a)
PPM1F 36
  • 55 (a)
(Anolis carolinensis)
Reptilia PPM1F 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1f 35
  • 59.77 (n)
  • 58.06 (a)
(Danio rerio)
Actinopterygii ppm1f 35
  • 55.94 (n)
  • 53.87 (a)
ppm1f 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002147 35
  • 51.14 (n)
  • 41.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10376 35
  • 49.42 (n)
  • 40.86 (a)
CG10376 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea fem-2 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 36
  • 32 (a)
(Oryza sativa)
Liliopsida Os06g0526800 35
  • 48.79 (n)
  • 42.46 (a)
Species with no ortholog for PPM1F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1F Gene

Gene Tree for PPM1F (if available)
Gene Tree for PPM1F (if available)

Paralogs for PPM1F Gene

Paralogs for PPM1F Gene

(3) SIMAP similar genes for PPM1F Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PPM1F: view

Variants for PPM1F Gene

Sequence variations from dbSNP and Humsavar for PPM1F Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs94194 -- 21,933,937(+) CTTGG(C/T)GGGCA intron-variant
rs239929 -- 21,948,390(-) GTCAG(C/T)GTCCC intron-variant
rs239930 -- 21,948,304(-) ggggg(A/G)ggtgg intron-variant
rs240061 -- 21,923,302(+) AGCCC(A/G)CTGCC reference, synonymous-codon
rs240062 -- 21,924,217(+) AGCCT(A/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1F Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv20e196 CNV Duplication 17116639
esv2422374 CNV Duplication 17116639
dgv22e196 CNV Deletion 17116639
esv2422338 CNV Deletion 17116639
dgv23e196 CNV Deletion 17116639
nsv469782 CNV Gain 16826518
nsv834146 CNV Gain 17160897
esv2422476 CNV Deletion 17116639
dgv4884n71 CNV Loss 21882294
nsv914473 CNV Loss 21882294
nsv3566 CNV Insertion 18451855
nsv828966 CNV Loss 20364138
nsv516394 CNV Gain+Loss 19592680
dgv1388e1 CNV Complex 17122850
nsv914475 CNV Gain 21882294
dgv4885n71 CNV Gain 21882294

Relevant External Links for PPM1F Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1F Gene

Disorders for PPM1F Gene

Relevant External Links for PPM1F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PPM1F Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PPM1F Gene

Publications for PPM1F Gene

  1. The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PMID: 11559703) Tan K.M.L. … Yu V.C. (J. Biol. Chem. 2001) 2 3 4 23
  2. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (PMID: 11864573) Koh C.-G. … Lim L. (Curr. Biol. 2002) 2 3 4 23
  3. Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts. (PMID: 15140879) Harvey B.P. … Ozer H.L. (J. Biol. Chem. 2004) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4

Products for PPM1F Gene

Sources for PPM1F Gene

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