Aliases for PPM1E Gene
- Protein Phosphatase, Mg2+/Mn2+ Dependent 1E 2 3 5
- Partner Of PIX 1 2 3 4
- Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase N 3 4
- Nuclear Calmodulin-Dependent Protein Kinase Phosphatase 2 3
- Protein Phosphatase 1E (PP2C Domain Containing) 2 3
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1E 2 3
- Partner Of PIX-Alpha 3 4
- Partner Of PIXA 3 4
External Ids for PPM1E Gene
Previous GeneCards Identifiers for PPM1E Gene
This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for PPM1E Gene
PPM1E (Protein Phosphatase, Mg2+/Mn2+ Dependent 1E) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1L.
UniProtKB/Swiss-Prot for PPM1E Gene
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).