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Aliases for PPM1E Gene

Aliases for PPM1E Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1E 2 3 5
  • Partner Of PIX 1 2 3 4
  • Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase N 3 4
  • Nuclear Calmodulin-Dependent Protein Kinase Phosphatase 2 3
  • Protein Phosphatase 1E (PP2C Domain Containing) 2 3
  • Partner Of PIX-Alpha 3 4
  • Partner Of PIXA 3 4
  • CaMKP-Nucleus 3 4
  • CaMKP-N 3 4
  • CaMKN 3 4
  • POPX1 3 4
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1E 2
  • Protein Phosphatase 1E 3
  • EC 3.1.3.16 4
  • KIAA1072 4
  • PP2CH 3

External Ids for PPM1E Gene

Previous GeneCards Identifiers for PPM1E Gene

  • GC17P059314
  • GC17P057175
  • GC17P057307
  • GC17P054188
  • GC17P056833
  • GC17P052193

Summaries for PPM1E Gene

Entrez Gene Summary for PPM1E Gene

  • This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PPM1E Gene

PPM1E (Protein Phosphatase, Mg2+/Mn2+ Dependent 1E) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1F.

UniProtKB/Swiss-Prot for PPM1E Gene

  • Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1E Gene

Genomics for PPM1E Gene

Regulatory Elements for PPM1E Gene

Enhancers for PPM1E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F058785 1.3 Ensembl ENCODE 11.8 +30.9 30860 1.5 PKNOX1 ATF1 ARNT SIN3A FEZF1 GATA2 FOS JUNB ZHX2 NCOA1 TRIM37 TEX14 PPM1E ENSG00000276601 GC17P058810
GH17F058991 1.2 Ensembl ENCODE 10.8 +236.8 236818 3.1 HDGF ZNF133 SIN3A PTRF RAD21 RARA YY1 SCRT2 FOS ZNF362 PPM1E MTMR4 ENSG00000212195 GC17P058985 GC17M059024
GH17F058614 1.1 Ensembl ENCODE 10.5 -140.3 -140268 1.6 PKNOX1 TBL1XR1 ETV1 ASH2L MAX RELA POLR2A EED ETV6 CREM TRIM37 SEPT4 C17orf47 MTMR4 PPM1E PIR61090 ENSG00000212195 GC17M058632
GH17F058702 1 ENCODE 11.3 -52.7 -52660 1.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ELK1 ZNF143 FOS RAD51C PPM1E TEX14 GC17M058695 ENSG00000274198
GH17F058657 1.9 FANTOM5 Ensembl ENCODE 1.5 -97.0 -96959 2.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SRSF1 TRIM37 RAD51C VEZF1 SMG8 SETP3 OR4D1 SPDYE22P ENSG00000264914 CCDC182
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPM1E on UCSC Golden Path with GeneCards custom track

Promoters for PPM1E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001808474 431 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF207 KLF13

Genomic Location for PPM1E Gene

Chromosome:
17
Start:
58,755,869 bp from pter
End:
58,985,179 bp from pter
Size:
229,311 bases
Orientation:
Plus strand

Genomic View for PPM1E Gene

Genes around PPM1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1E Gene

Proteins for PPM1E Gene

  • Protein details for PPM1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY54-PPM1E_HUMAN
    Recommended name:
    Protein phosphatase 1E
    Protein Accession:
    Q8WY54
    Secondary Accessions:
    • Q68DW1
    • Q7LAF3
    • Q9UPT0

    Protein attributes for PPM1E Gene

    Size:
    764 amino acids
    Molecular mass:
    85002 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).
    SequenceCaution:
    • Sequence=BAA83024.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPM1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1E Gene

Post-translational modifications for PPM1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPM1E Gene

No data available for DME Specific Peptides for PPM1E Gene

Domains & Families for PPM1E Gene

Gene Families for PPM1E Gene

Protein Domains for PPM1E Gene

Suggested Antigen Peptide Sequences for PPM1E Gene

Graphical View of Domain Structure for InterPro Entry

Q8WY54

UniProtKB/Swiss-Prot:

PPM1E_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1E: view

Function for PPM1E Gene

Molecular function for PPM1E Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).

Enzyme Numbers (IUBMB) for PPM1E Gene

Gene Ontology (GO) - Molecular Function for PPM1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IDA 20801214
GO:0005515 protein binding IPI 11864573
GO:0016787 hydrolase activity IEA --
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with PPM1E: view
genes like me logo Genes that share phenotypes with PPM1E: view

Animal Model Products

miRNA for PPM1E Gene

miRTarBase miRNAs that target PPM1E

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPM1E Gene

Localization for PPM1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1E Gene

Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus. {ECO:0000269 PubMed:15496589, ECO:0000269 PubMed:16269004}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1E gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PPM1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0043234 protein complex IDA 11864573
genes like me logo Genes that share ontologies with PPM1E: view

Pathways & Interactions for PPM1E Gene

SuperPathways for PPM1E Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPM1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 11864573
GO:0006470 protein dephosphorylation IEA --
GO:0035690 cellular response to drug IDA 20801214
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
GO:0051496 positive regulation of stress fiber assembly IDA 11864573
genes like me logo Genes that share ontologies with PPM1E: view

No data available for Pathways by source and SIGNOR curated interactions for PPM1E Gene

Drugs & Compounds for PPM1E Gene

(5) Drugs for PPM1E Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for PPM1E Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PPM1E: view

Transcripts for PPM1E Gene

mRNA/cDNA for PPM1E Gene

Unigene Clusters for PPM1E Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1E:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1E Gene

No ASD Table

Relevant External Links for PPM1E Gene

GeneLoc Exon Structure for
PPM1E
ECgene alternative splicing isoforms for
PPM1E

Expression for PPM1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPM1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1E Gene

This gene is overexpressed in Testis (x8.7), Brain - Hippocampus (x4.9), Brain - Frontal Cortex (BA9) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for PPM1E Gene

This gene is overexpressed in Fetal Brain (33.2), Frontal cortex (11.2), Retina (9.2), and Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPM1E Gene



Protein tissue co-expression partners for PPM1E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1E Gene:

PPM1E

SOURCE GeneReport for Unigene cluster for PPM1E Gene:

Hs.245044
genes like me logo Genes that share expression patterns with PPM1E: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PPM1E Gene

Orthologs for PPM1E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1E 34 35
  • 96.93 (n)
cow
(Bos Taurus)
Mammalia PPM1E 34 35
  • 91.6 (n)
dog
(Canis familiaris)
Mammalia PPM1E 34 35
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Ppm1e 34
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Ppm1e 34 16 35
  • 87.87 (n)
oppossum
(Monodelphis domestica)
Mammalia PPM1E 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1E 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1E 34 35
  • 76.36 (n)
lizard
(Anolis carolinensis)
Reptilia PPM1E 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1e 34
  • 69.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4149 34
zebrafish
(Danio rerio)
Actinopterygii ppm1e 34 35
  • 69.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10376 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fem-2 35
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8295 34
Species where no ortholog for PPM1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1E Gene

ENSEMBL:
Gene Tree for PPM1E (if available)
TreeFam:
Gene Tree for PPM1E (if available)

Paralogs for PPM1E Gene

Paralogs for PPM1E Gene

(1) SIMAP similar genes for PPM1E Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPM1E: view

Variants for PPM1E Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1E Gene

PPM1E_HUMAN-Q8WY54
The poly-Pro-Glu stretch is polymorphic.

Sequence variations from dbSNP and Humsavar for PPM1E Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036518 A breast cancer sample
VAR_036519 A breast cancer sample
rs1001716 -- 58,776,888(-) TCTAA(G/T)CATTA intron-variant
rs1018051 -- 58,832,565(+) TGGAG(C/T)GTAGG intron-variant
rs10221208 -- 58,970,524(+) CTTTT(C/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1E Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv4279n106 CNV deletion 24896259
esv1008894 CNV deletion 20482838
esv2662399 CNV deletion 23128226
esv2671869 CNV deletion 23128226
esv2716080 CNV deletion 23290073
esv3559209 CNV deletion 23714750
esv3582850 CNV loss 25503493
esv3640894 CNV loss 21293372
esv3640895 CNV loss 21293372
esv3640896 CNV loss 21293372
nsv955396 CNV deletion 24416366
nsv833498 CNV loss 17160897
nsv828067 CNV loss 20364138
nsv510719 CNV deletion 20534489
nsv477646 CNV novel sequence insertion 20440878
nsv1065063 CNV gain 25217958
nsv1057312 CNV gain 25217958
esv3640898 CNV loss 21293372
esv3640897 CNV loss 21293372

Variation tolerance for PPM1E Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.80; 94.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPM1E

Disorders for PPM1E Gene

Relevant External Links for PPM1E

Genetic Association Database (GAD)
PPM1E
Human Genome Epidemiology (HuGE) Navigator
PPM1E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1E

No disorders were found for PPM1E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1E Gene

Publications for PPM1E Gene

  1. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (PMID: 11864573) Koh C.-G. … Lim L. (Curr. Biol. 2002) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 3 46 64
  4. Identification and characterization of nuclear localization signals of CaMKP-N. (PMID: 15496589) Takeuchi M. … Fujisawa H. (J. Biochem. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for PPM1E Gene

Sources for PPM1E Gene

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