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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPM1D Gene

protein-coding   GIFtS: 61
GCID: GC17P058677

protein phosphatase, Mg2+/Mn2+ dependent, 1D

(Previous names: protein phosphatase 1D magnesium-dependent, delta isoform...)
 Explore 10 diseases affiliated with
PPM1D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPM1D    

Aliases
for PPM1D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D1 2     Protein Phosphatase 2C Delta Isoform2
WIP12 3 5     Protein Phosphatase Wip12
PP2C-DELTA1 2     Wild-Type P53-Induced Phosphatase 12
Protein Phosphatase 1D Magnesium-Dependent, Delta Isoform1 2     EC 3.1.3.163
Protein Phosphatase Magnesium-Dependent 1 Delta2 3     PP2C-Delta1
Wip11     P53-Induced Protein Phosphatase 13
Protein Phosphatase 1D2     Protein Phosphatase 2C Isoform Delta3

External Ids:    HGNC: 92771   Entrez Gene: 84932   Ensembl: ENSG000001708367   OMIM: 6051005   UniProtKB: O152973   

Export aliases for PPM1D gene to outside databases

Previous GC identifers: GC17P058414 GC17P061129 GC17P059019 GC17P059151 GC17P056032 GC17P054048


Summaries
for PPM1D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPM1D:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members
are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a
p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein
TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the
phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus
mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of
stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The
amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests
a role of this gene in cancer development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPM1D_HUMAN, O15297
Function: Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates
'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins

Gene Wiki entry for PPM1D


Genomic Views
for PPM1D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPM1D gene promoter:
         FOXD1   CUTL1   Meis-1b   Egr-2   HEN1   Nkx6-1   FOXO4   Meis-1a   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPM1D promoter sequence
   Search SABiosciences Chromatin IP Primers for PPM1D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPM1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.3

PPM1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1D gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P058677:  view genomic region     (about GC identifiers)

Start:
 58,677,544 bp from pter      End:
 58,742,036 bp from pter
Size:
 64,493 bases      Orientation:
 plus strand

Proteins
for PPM1D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPM1D_HUMAN, O15297 (See protein sequence)
Recommended Name: Protein phosphatase 1D  
Size: 605 amino acids; 66675 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Subunit: Interacts with CHEK1 and CHEK2; dephosphorylates them
Secondary accessions: Q53XP4

Explore the universe of human proteins at neXtProt for PPM1D: NX_O15297

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15297

    • PPM1D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003611.1  
    ENSEMBL proteins: 
     ENSP00000306682   ENSP00000376720   ENSP00000465168  

    Human Recombinant Protein Products: 
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    Novus Biologicals PPM1D Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PPM1D

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9177166
    GO:0008287protein serine/threonine phosphatase complex ----


    PPM1D for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PPM1D

    Protein Domains /
    Families
    for PPM1D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPM1D for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001932 PP2C-like
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry O15297

    ProtoNet protein and cluster: O15297

    UniProtKB/Swiss-Prot: PPM1D_HUMAN, O15297
    Similarity: Belongs to the PP2C family
    Similarity: Contains 1 PP2C-like domain


    Function
    for PPM1D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPM1D_HUMAN, O15297
    Function: Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates
    'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Induction: By p53/TP53

    Enzyme Number (IUBMB): EC 3.1.3.161

    miRNA
    Products:            		miRTarBase miRNAs that target PPM1D:
    hsa-mir-203 (MIRT005684), hsa-mir-145 (MIRT005683), hsa-mir-29a (MIRT004044), hsa-mir-16 (MIRT005360), hsa-mir-217 (MIRT005685), hsa-mir-153 (MIRT005682)

    OriGene 3'-UTR Clone: PPM1D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPM1D
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1D (see all 75):
    hsa-miR-361-5p hsa-miR-300 hsa-miR-15a hsa-miR-3653 hsa-miR-4275 hsa-miR-208b hsa-miR-376a* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: PPM1D 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPM1D (see all 7)
    OriGene shRNA RFP: PPM1D
    OriGene siRNA: PPM1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPM1D

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPM1D

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1D (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1D (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPM1D (NM_003620)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1D 

    Cell Line
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    Search LifeMap BioReagents cell lines for PPM1D

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1D

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004722protein serine/threonine phosphatase activity IDA--
    GO:0005515protein binding IPI17936559
    GO:0046872metal ion binding IEA--


    PPM1D for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PPM1D:
     Decreased viability with pacli  Increased cell death in breast 

    Animal Models:
         Mouse knock-out Ppm1dtm1Lad for PPM1D
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ppm1d):
     cellular  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     integument  mortality/aging  reproductive system  tumorigenesis 

    PPM1D for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPM1D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and survival BAD phosphorylation
    		Apoptosis and survival BAD phosphorylation1.00
    		Apoptosis and survival_BAD phosphorylation0.99
    2p53 pathway
    		p53 pathway1.00
    3p53 signaling pathway
    		p53 signaling pathway1.00
    4DNA Damage
    		DNA Damage1.00
    5wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    		Regulation of CFTR activity (norm and CF)0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PPM1D
        Apoptosis and survival BAD phosphorylation


    1 Cell Signaling Technology (CST) Pathway for PPM1D
        DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for PPM1D
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for PPM1D 
        p53 pathway


    1         Kegg Pathway  (Kegg details for PPM1D):
        p53 signaling pathway


    PPM1D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPM1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/578 Interacting proteins for PPM1D (O152971, 2, 3 ENSP000003066824) via UniProtKB, MINT, STRING, and/or I2D (see all 578)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161042, 3, ENSP000003643104MINT-8291621 MINT-8291572 MINT-8291642 MINT-8291601 MINT-8291635 MINT-8291610 I2D: score=2 STRING: ENSP00000364310
    MDM2Q009871, 3, ENSP000004172814EBI-1551512,EBI-389668 I2D: score=3 STRING: ENSP00000417281
    CDC5LQ994592, 3, ENSP000003605324MINT-7947479 I2D: score=1 STRING: ENSP00000360532
    NCLP193383, ENSP000003181954I2D: score=2 STRING: ENSP00000318195
    RPL5P467773, ENSP000003593454I2D: score=2 STRING: ENSP00000359345
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IEA--
    GO:0006470protein dephosphorylation TAS9177166
    GO:0008285negative regulation of cell proliferation TAS9177166
    GO:0009314response to radiation TAS9177166
    GO:0009617response to bacterium IEA--


    PPM1D for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPM1D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPM1D for compounds           About GeneDecksing

    EMD Millipore small molecules for PPM1D:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPM1D

    5 HMDB Compounds for PPM1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    2 Novoseek chemical compound relationships for PPM1D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 61.7 16 15807522 (2), 11101524 (1), 15327777 (1), 16652371 (1) (see all 9)
    serine 44.1 12 15327777 (1), 16652371 (1), 18265945 (1), 16897432 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about PPM1D 

    Transcripts
    for PPM1D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPM1D gene: 
    NM_003620.3  

    Unigene Cluster for PPM1D:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1D
    Hs.286073  [show with all ESTs]
    Unigene Representative Sequence: NM_003620
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305921(uc002iyt.2 uc010ddm.2) ENST00000392995 ENST00000590418


    miRNA
    Products:             		 OriGene 3'-UTR Clone: PPM1D
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPM1D
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1D (see all 75):
    hsa-miR-361-5p hsa-miR-300 hsa-miR-15a hsa-miR-3653 hsa-miR-4275 hsa-miR-208b hsa-miR-376a* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: PPM1D 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPM1D (see all 7)
    OriGene shRNA RFP: PPM1D
    OriGene siRNA: PPM1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPM1D
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1D (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPM1D (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPM1D (NM_003620)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1D 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPM1D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPM1D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPM1D

    Additional cDNA sequence: 

    AK054573.1 AK312902.1 BC016480.1 BC032826.1 BC033893.2 BC060877.1 BT009780.1 U78305.1 

    4 DOTS entries:

    DT.456381  DT.109318  DT.100766065  DT.100766068 

    24/75 AceView cDNA sequences (see all 75):

    AW025045 BM974101 BF910408 BX107623 BQ010896 AI024631 BU521853 AA412202 
    AA399213 BQ900713 BE046472 AA256510 AA609470 BU616782 AK054573 CK823233 
    BQ019149 CD367090 AI275159 BF432098 CD365077 BX104973 BU189763 CA449682 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPM1D    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:              -                                         -               
    SP2:              -                                   -     -               
    SP3:                                                  -                     
    SP4:                                                                        


    ECgene alternative splicing isoforms for PPM1D

    Expression
    for PPM1D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPM1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PPM1D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPM1D

    SOURCE GeneReport for Unigene cluster: Hs.286073
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPM1D: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPM1D
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPM1D
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPM1D
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPM1D
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1D

    Orthologs
    for PPM1D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPM1D gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppm1d1 , 5 protein phosphatase 1D magnesium-dependent, delta isoform less1, 5 87.19(n)1
    89.93(a)1    		   11 (51.34 cM)5
    538921  NM_016910.31  NP_058606.31 
     853112445 
    chicken
    (Gallus gallus)    		 Aves PPM1D1 protein phosphatase, Mg2+/Mn2+ dependent, 1D 72.71(n)
    75.96(a)    		   417644  XM_415890.3  XP_415890.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PPM1D6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343393.1(518656-532291)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ppm1d-prov2 protein phosphatase 1D magnesium-dependent, delta isoform less 74.23(n)    BC044985.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc558362 similar to protein phosphatase 1D magnesium-dependent, delta isoform less 76.41(n)   394065  BC045471.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pp2C13 protein amino acid dephosphorylation protein
    serine/threonine phosphatase less    		 47(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54F10BM.13   -- 38(a)   III(2403398-2416069)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G200506
    AT5G260106
    (see all 14)    		 putative protein phosphatase 2C 72
    (see all 14)    		 8(a)
    21(a)
    (see all 14)    		 many → 1
    many → 1
    (see all 14)    		 2(8649434-8654450)
    5(9085393-9087372)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 11)    		 protein phosphatase 2C, putative, expressed
    (see all 11)    		 8(a)
    20(a)
    (see all 11)    		 many → 1
    many → 1
    (see all 11)    		 2(10419060-10428058)
    7(22724808-22730328)


    ENSEMBL Gene Tree for PPM1D (if available)
    TreeFam Gene Tree for PPM1D (if available) 

    Paralogs
    for PPM1D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPM1D gene
    PPM1A2  PPM1B2  PPM1N2  PPM1G2  

    PPM1D for paralogs           About GeneDecksing



    Genomic Variants
    for PPM1D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1012 NCBI SNPs in PPM1D are shown (see all 1012)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739925731,2
    		C,--58675576(+) TAGTGG/AAAGAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1157663871,2
    		F,--58675617(+) GGAGAT/CACCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1455230361,2
    		--58675681(+) AGCACC/TTGAGT 1 -- us2k10--------
    rs1450244081,2
    		--58675725(+) GGTAAC/TATGAG 1 -- us2k10--------
    rs1925242601,2
    		--58675766(+) AGGAAA/GAATAA 1 -- us2k10--------
    rs1490801951,2
    		--58675796(+) TGCAAA/GGGAGG 1 -- us2k10--------
    rs1181228371,2
    		C,F,--58676013(+) ATAAAC/TGGATG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1433143331,2
    		--58676315(+) TTTTTC/TCAAGC 1 -- us2k10--------
    rs1823529371,2
    		--58676334(+) GCCCTA/GGAACC 1 -- us2k10--------
    rs1866212821,2
    		--58676388(+) ATTTAC/TTTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPM1D (58677544 - 58742036 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPM1D: --
    Human Gene Mutation Database (HGMD): PPM1D

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PPM1D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPM1D for disorders           About GeneDecksing

    OMIM gene information: 605100   
    OMIM disorders: 114480  
    10 diseases for PPM1D:    About MalaCards
    breast cancer    medulloblastoma    lung adenocarcinoma    astrocytoma
    adenocarcinoma    neuroblastoma    malaria    carcinoma
    desmoplastic medulloblastoma    ovarian cancer

    4 Novoseek disease relationships for PPM1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medulloblastoma 51.7 6 17932621 (3), 16314645 (2)
    tumors 29.5 17 12702577 (2), 17932621 (2), 20093361 (1), 16314645 (1) (see all 11)
    breast cancer 27.4 17 16897432 (3), 17977650 (3), 16352595 (2), 12755490 (1) (see all 6)
    cancer 18.9 14 18265945 (2), 17073441 (1), 19015127 (1), 17977650 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: PPM1D (1 document)

    Export disorders for PPM1D gene to outside databases

    Publications
    for PPM1D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPM1D gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with PPM1D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. (PubMed id 9177166)1, 2, 3 Fiscella M.... Appella E. (1997)
    2. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. (PubMed id 15870257)1, 2, 9 Lu X.... Donehower L.A. (2005)
    3. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. (PubMed id 16311512)1, 2, 9 Fujimoto H....Minami Y. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. (PubMed id 16798742)1, 9 Yoda A....Minami Y. (2006)
    6. Expression of a homeostatic regulator, Wip1 (wild-typ e p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation. (PubMed id 20093361)1, 9 Song J.Y....Choi J. (2010)
    7. The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression. (PubMed id 19435816)1, 9 Han H.S....Choi J. (2009)
    8. Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. (PubMed id 19015127)1, 9 Rossi M....Mazur S.J. (2008)
    9. Characterization of the active site and a unique uncompetitive inhibitor of the PPM1-type protein phosphatase PPM1D. (PubMed id 18991770)1, 9 Chuman Y....Sakaguchi K. (2008)
    10. Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers. (PubMed id 16897432)1, 9 Yu E....Choi J. (2007)

    External Searches for PPM1D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing PPM1D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8493 HGNC: 9277 AceView: PPM1D Ensembl:ENSG00000170836 euGenes: HUgn8493
    ECgene: PPM1D Kegg: 8493 H-InvDB: PPM1D

    Other Databases showing PPM1D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPM1D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPM1D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPM1D Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PPM1D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPM1D gene:
    Search GeneIP for patents involving PPM1D

    GeneCards and IP:
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