Aliases for PPM1D Gene
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 2 3
- WIP1 3 4 6
- Protein Phosphatase 1D Magnesium-Dependent, Delta Isoform 2 3
- Wild-Type P53-Induced Phosphatase 1 2 3
- PP2C-DELTA 3 4
- Protein Phosphatase Magnesium-Dependent 1 Delta 4
- Protein Phosphatase 2C Delta Isoform 3
- Protein Phosphatase 2C Isoform Delta 4
External Ids for PPM1D Gene
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPM1D Gene
PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D) is a Protein Coding gene. Diseases associated with PPM1D include breast cancer. Among its related pathways are Cell Cycle / Checkpoint Control and p53 pathway. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1G.
UniProtKB/Swiss-Prot for PPM1D Gene
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates Ser-15 of TP53 and Ser-345 of CHEK1 which contributes to the functional inactivation of these proteins.