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Aliases for PPM1D Gene

Aliases for PPM1D Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1D 2 3 5
  • Protein Phosphatase 1D Magnesium-Dependent, Delta Isoform 2 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 2 3
  • Wild-Type P53-Induced Phosphatase 1 2 3
  • PP2C-DELTA 3 4
  • WIP1 3 4
  • Protein Phosphatase Magnesium-Dependent 1 Delta 4
  • Protein Phosphatase Mg2+/Mn2+ Dependent 1D 3
  • Protein Phosphatase 2C Delta Isoform 3
  • Protein Phosphatase 2C Isoform Delta 4
  • P53-Induced Protein Phosphatase 1 4
  • Protein Phosphatase Wip1 3
  • Protein Phosphatase 2C 2
  • Delta Isoform 2
  • EC 3.1.3.16 4

External Ids for PPM1D Gene

Previous GeneCards Identifiers for PPM1D Gene

  • GC17P058414
  • GC17P061129
  • GC17P059019
  • GC17P059151
  • GC17P056032
  • GC17P058677
  • GC17P054048

Summaries for PPM1D Gene

Entrez Gene Summary for PPM1D Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1D Gene

PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent 1D) is a Protein Coding gene. Diseases associated with PPM1D include breast cancer and brca1 and brca2 hereditary breast and ovarian cancer. Among its related pathways are p53 pathway (Pathway Interaction Database) and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E.

UniProtKB/Swiss-Prot for PPM1D Gene

  • Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates Ser-15 of TP53 and Ser-345 of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).

Gene Wiki entry for PPM1D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1D Gene

Genomics for PPM1D Gene

Regulatory Elements for PPM1D Gene

Promoters for PPM1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPM1D on UCSC Golden Path with GeneCards custom track

Genomic Location for PPM1D Gene

Chromosome:
17
Start:
60,600,183 bp from pter
End:
60,666,280 bp from pter
Size:
66,098 bases
Orientation:
Plus strand

Genomic View for PPM1D Gene

Genes around PPM1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1D Gene

Proteins for PPM1D Gene

  • Protein details for PPM1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15297-PPM1D_HUMAN
    Recommended name:
    Protein phosphatase 1D
    Protein Accession:
    O15297
    Secondary Accessions:
    • Q53XP4
    • Q6P991
    • Q8IVR6

    Protein attributes for PPM1D Gene

    Size:
    605 amino acids
    Molecular mass:
    66675 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with CHEK1 and CHEK2; dephosphorylates them. Interacts with MAPK14 (PubMed:21283629).

    Alternative splice isoforms for PPM1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1D Gene

Proteomics data for PPM1D Gene at MOPED

Post-translational modifications for PPM1D Gene

  • Ubiquitination at Lys 238
  • Modification sites at PhosphoSitePlus

Other Protein References for PPM1D Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPM1D (PPM1D)

No data available for DME Specific Peptides for PPM1D Gene

Domains & Families for PPM1D Gene

Gene Families for PPM1D Gene

Protein Domains for PPM1D Gene

Graphical View of Domain Structure for InterPro Entry

O15297

UniProtKB/Swiss-Prot:

PPM1D_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1D: view

Function for PPM1D Gene

Molecular function for PPM1D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates Ser-15 of TP53 and Ser-345 of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Enzyme Numbers (IUBMB) for PPM1D Gene

Gene Ontology (GO) - Molecular Function for PPM1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17936559
genes like me logo Genes that share ontologies with PPM1D: view
genes like me logo Genes that share phenotypes with PPM1D: view

Human Phenotype Ontology for PPM1D Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPM1D Gene

MGI Knock Outs for PPM1D:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PPM1D Gene

Localization for PPM1D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPM1D Gene COMPARTMENTS Subcellular localization image for PPM1D gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPM1D Gene

Pathways & Interactions for PPM1D Gene

genes like me logo Genes that share pathways with PPM1D: view

Pathways by source for PPM1D Gene

1 BioSystems pathway for PPM1D Gene
1 KEGG pathway for PPM1D Gene

SIGNOR curated interactions for PPM1D Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PPM1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
genes like me logo Genes that share ontologies with PPM1D: view

Drugs & Compounds for PPM1D Gene

(6) Drugs for PPM1D Gene - From: HMDB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCT007093 Pharma PPM1D inhibitor 0
Manganese Pharma 32
calcium Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for PPM1D Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(1) ApexBio Compounds for PPM1D Gene

Compound Action Cas Number
CCT007093 PPM1D inhibitor 176957-55-4
genes like me logo Genes that share compounds with PPM1D: view

Transcripts for PPM1D Gene

Unigene Clusters for PPM1D Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for PPM1D Gene

GeneLoc Exon Structure for
PPM1D
ECgene alternative splicing isoforms for
PPM1D

Expression for PPM1D Gene

mRNA expression in normal human tissues for PPM1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPM1D Gene

This gene is overexpressed in Platelet (55.0) and Placenta (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPM1D Gene



SOURCE GeneReport for Unigene cluster for PPM1D Gene Hs.286073

genes like me logo Genes that share expression patterns with PPM1D: view

Protein tissue co-expression partners for PPM1D Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPM1D Gene

Orthologs for PPM1D Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPM1D 35
  • 89.81 (n)
  • 91.9 (a)
PPM1D 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPM1D 35
  • 93.06 (n)
  • 94.38 (a)
PPM1D 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppm1d 35
  • 87.19 (n)
  • 89.93 (a)
Ppm1d 16
Ppm1d 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPM1D 35
  • 99.5 (n)
  • 99.34 (a)
PPM1D 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1d 35
  • 87.7 (n)
  • 90.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PPM1D 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1D 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1D 35
  • 72.71 (n)
  • 75.96 (a)
PPM1D 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPM1D 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1d 35
  • 64.65 (n)
  • 66.3 (a)
African clawed frog
(Xenopus laevis)
Amphibia ppm1d-prov 35
zebrafish
(Danio rerio)
Actinopterygii ppm1da 35
  • 61.68 (n)
  • 63.64 (a)
zgc55836 35
ppm1da 36
  • 51 (a)
OneToMany
ppm1db 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pp2C1 37
  • 47 (a)
Pp2C1 36
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y54F10BM.1 37
  • 38 (a)
Y54F10BM.1 36
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC4 36
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6123 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToOne
Species with no ortholog for PPM1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1D Gene

ENSEMBL:
Gene Tree for PPM1D (if available)
TreeFam:
Gene Tree for PPM1D (if available)

Paralogs for PPM1D Gene

Paralogs for PPM1D Gene

genes like me logo Genes that share paralogs with PPM1D: view

Variants for PPM1D Gene

Sequence variations from dbSNP and Humsavar for PPM1D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17855093 - 60,648,030(+) TCCAC(A/C)ACAAG nc-transcript-variant, reference, missense
rs1058864 -- 60,665,562(+) TTTTG(A/C)AGAAG utr-variant-3-prime
rs1494959 -- 60,601,633(+) TCCCA(A/C)CCGGT intron-variant
rs1960355 -- 60,652,495(-) caaca(A/G)aaaga intron-variant
rs1960356 -- 60,652,326(-) ccata(A/G)aaaaa intron-variant

Variation tolerance for PPM1D Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1D Gene

HapMap Linkage Disequilibrium report
PPM1D
Human Gene Mutation Database (HGMD)
PPM1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPM1D Gene

Disorders for PPM1D Gene

MalaCards: The human disease database

(4) MalaCards diseases for PPM1D Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
brca1 and brca2 hereditary breast and ovarian cancer
  • hboc
familial breast cancer
  • breast cancer, familial
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards
Search PPM1D in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPM1D

Genetic Association Database (GAD)
PPM1D
Human Genome Epidemiology (HuGE) Navigator
PPM1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1D
genes like me logo Genes that share disorders with PPM1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPM1D Gene

Publications for PPM1D Gene

  1. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. (PMID: 9177166) Fiscella M. … Appella E. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 67
  2. Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation. (PMID: 20093361) Song J.Y. … Choi J. (J. Biol. Chem. 2010) 3 23
  3. Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. (PMID: 20118229) Moon S.H. … Donehower L.A. (J. Biol. Chem. 2010) 3 23
  4. The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression. (PMID: 19435816) Han H.S. … Choi J. (Mol. Cancer Res. 2009) 3 23
  5. Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. (PMID: 19713933) Lindqvist A. … Medema R.H. (EMBO J. 2009) 3 23

Products for PPM1D Gene

Sources for PPM1D Gene

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