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Aliases for PPM1B Gene

Aliases for PPM1B Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1B 2 3 5
  • Protein Phosphatase 1B (Formerly 2C), Magnesium-Dependent, Beta Isoform 2 3
  • EC 3.1.3.16 4 61
  • PP2C-Beta 3 4
  • PP2CB 3 4
  • Ser/Thr Protein Phosphatase Type 2C Beta 2 Isoform 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B 2
  • Protein Phosphatase 2C, Beta Isoform 2
  • Protein Phosphatase 2C-Like Protein 3
  • Protein Phosphatase 2C Isoform Beta 4
  • Protein Phosphatase 1B 3
  • PP2C-Beta-X 3
  • PPC2BETAX 3
  • PP2CBETA 3

External Ids for PPM1B Gene

Previous GeneCards Identifiers for PPM1B Gene

  • GC02P044394
  • GC02P044564
  • GC02P044370
  • GC02P044307
  • GC02P044395

Summaries for PPM1B Gene

Entrez Gene Summary for PPM1B Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1B Gene

PPM1B (Protein Phosphatase, Mg2+/Mn2+ Dependent 1B) is a Protein Coding gene. Diseases associated with PPM1B include Hypotonia-Cystinuria Syndrome and Cystinuria. Among its related pathways are Interferon gamma signaling and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include magnesium ion binding and manganese ion binding. An important paralog of this gene is PPM1A.

UniProtKB/Swiss-Prot for PPM1B Gene

  • Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at Ser-172. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Gene Wiki entry for PPM1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1B Gene

Genomics for PPM1B Gene

Regulatory Elements for PPM1B Gene

Enhancers for PPM1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G044099 0.8 Ensembl ENCODE 12 -67.4 -67363 1.4 FOSL1 JUND BHLHE40 FOS ZNF644 MAFK RNU6-566P PPM1B ENSG00000219391
GH02G043517 1.5 FANTOM5 Ensembl ENCODE 4.6 -648.7 -648742 4.0 FOXA2 ARID4B ZNF48 FOS MIER2 PPARG KAT8 NFIL3 MIER3 RCOR2 PPM1B ZFP36L2 GC02M043477 THADA
GH02G044166 1.4 ENCODE dbSUPER 4.7 +1.5 1481 5.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 LRPPRC PPM1B LOC102723904 RPL12P19
GH02G044243 1 Ensembl ENCODE 5.1 +77.3 77314 3.1 CTCF MXI1 MLX SIN3A MAX CEBPG ZNF384 ZSCAN9 RAD21 GATA2 LRPPRC PPM1B RPL12P19 LOC102723904
GH02G044167 0.2 ENCODE 0.7 -1.7 -1673 0.2 PDSS1P2 PPM1B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPM1B on UCSC Golden Path with GeneCards custom track

Promoters for PPM1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000116264 1432 4000 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for PPM1B Gene

Chromosome:
2
Start:
44,167,969 bp from pter
End:
44,244,425 bp from pter
Size:
76,457 bases
Orientation:
Plus strand

Genomic View for PPM1B Gene

Genes around PPM1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1B Gene

Proteins for PPM1B Gene

  • Protein details for PPM1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75688-PPM1B_HUMAN
    Recommended name:
    Protein phosphatase 1B
    Protein Accession:
    O75688
    Secondary Accessions:
    • Q461Q2
    • Q4J6C1
    • Q4J6C2
    • Q658R4
    • Q96ER6
    • Q9HAY8

    Protein attributes for PPM1B Gene

    Size:
    479 amino acids
    Molecular mass:
    52643 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.

    Three dimensional structures from OCA and Proteopedia for PPM1B Gene

    Alternative splice isoforms for PPM1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1B Gene

Selected DME Specific Peptides for PPM1B Gene

O75688:
  • SVENVKNGIRTGFL
  • EKERIQNAGGSVMIQRVNGSLAVSRALGD
  • GKGPTEQLVSPEPEV
  • KRNVIEAVY
  • YFINCGDSR
  • KGSRDNMS
  • DRSGSTAVGV
  • GLSSMQGWR
  • GDSRAVL
  • LPPGGGL
  • WDVMSNEE
  • WSFFAVYDGHAGS

Post-translational modifications for PPM1B Gene

  • Isgylation negatively regulates its activity.
  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PPM1B (PP2C beta/PPM1B)

Domains & Families for PPM1B Gene

Gene Families for PPM1B Gene

Protein Domains for PPM1B Gene

Suggested Antigen Peptide Sequences for PPM1B Gene

Graphical View of Domain Structure for InterPro Entry

O75688

UniProtKB/Swiss-Prot:

PPM1B_HUMAN :
  • Belongs to the PP2C family.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1B: view

Function for PPM1B Gene

Molecular function for PPM1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at Ser-172. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Enzyme Numbers (IUBMB) for PPM1B Gene

Gene Ontology (GO) - Molecular Function for PPM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,IDA 20801214
GO:0005515 protein binding IPI 16872604
genes like me logo Genes that share ontologies with PPM1B: view
genes like me logo Genes that share phenotypes with PPM1B: view

Human Phenotype Ontology for PPM1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPM1B Gene

MGI Knock Outs for PPM1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Transcription Factor Targets and HOMER Transcription for PPM1B Gene

Localization for PPM1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1B Gene

Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250 UniProtKB:P36993}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1B gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PPM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with PPM1B: view

Pathways & Interactions for PPM1B Gene

genes like me logo Genes that share pathways with PPM1B: view

Pathways by source for PPM1B Gene

1 R&D Systems pathway for PPM1B Gene
1 Qiagen pathway for PPM1B Gene

SIGNOR curated interactions for PPM1B Gene

Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for PPM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP,IEA 18930133
GO:0006499 N-terminal protein myristoylation ISS --
GO:0032688 negative regulation of interferon-beta production IMP 22750291
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
GO:0042347 negative regulation of NF-kappaB import into nucleus IMP 18930133
genes like me logo Genes that share ontologies with PPM1B: view

Drugs & Compounds for PPM1B Gene

(7) Drugs for PPM1B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for PPM1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PPM1B: view

Transcripts for PPM1B Gene

Unigene Clusters for PPM1B Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7:

Relevant External Links for PPM1B Gene

GeneLoc Exon Structure for
PPM1B
ECgene alternative splicing isoforms for
PPM1B

Expression for PPM1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1B Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for PPM1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6) and Heart (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPM1B Gene



Protein tissue co-expression partners for PPM1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1B Gene:

PPM1B

SOURCE GeneReport for Unigene cluster for PPM1B Gene:

Hs.416769

mRNA Expression by UniProt/SwissProt for PPM1B Gene:

O75688-PPM1B_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PPM1B Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Adrenal gland(4.2)
  • Stomach(4.2)
  • Muscle(2.7)
  • Heart(2.4)
  • Spleen(2.2)
  • Lung(2.1)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • pituitary gland
  • skull
  • vocal cord
Thorax:
  • breast
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • ovary
  • penis
  • prostate
  • testicle
  • ureter
  • urinary bladder
  • uterus
  • vagina
  • vulva
General:
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with PPM1B: view

Primer Products

Orthologs for PPM1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1B 34 35
  • 99.93 (n)
dog
(Canis familiaris)
Mammalia PPM1B 34 35
  • 96.73 (n)
cow
(Bos Taurus)
Mammalia PPM1B 34 35
  • 94.81 (n)
rat
(Rattus norvegicus)
Mammalia Ppm1b 34
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Ppm1b 34 16 35
  • 90.01 (n)
oppossum
(Monodelphis domestica)
Mammalia PPM1B 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1B 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1B 34 35
  • 88.05 (n)
lizard
(Anolis carolinensis)
Reptilia PPM1B 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1b 34
  • 79.65 (n)
Str.3223 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10032 34
zebrafish
(Danio rerio)
Actinopterygii ppm1bb 35
  • 83 (a)
OneToMany
ppm1ba 34 35
  • 72.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008149 34
  • 55.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta alph 34 35
  • 54.3 (n)
CG6036 35
  • 49 (a)
ManyToMany
Ppm1 35
  • 38 (a)
ManyToMany
CG17746 35
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ppm-1 34 35
  • 57.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC3 35
  • 26 (a)
ManyToMany
PTC2 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3033 34
Species where no ortholog for PPM1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1B Gene

ENSEMBL:
Gene Tree for PPM1B (if available)
TreeFam:
Gene Tree for PPM1B (if available)

Paralogs for PPM1B Gene

Paralogs for PPM1B Gene

(3) SIMAP similar genes for PPM1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPM1B: view

Variants for PPM1B Gene

Sequence variations from dbSNP and Humsavar for PPM1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000038824 -- 44,179,513(+) AAGGA(C/G)AGAGA intron-variant
rs1000045112 -- 44,213,267(+) CTTTG(A/T)TATCA intron-variant
rs1000102603 -- 44,179,050(+) GAGGT(A/C)ATTGA intron-variant
rs1000105339 -- 44,194,720(+) TCCAT(C/T)TCAAA intron-variant
rs1000113008 -- 44,185,635(+) CTTAT(A/G)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1B Gene

Variant ID Type Subtype PubMed ID
esv3892015 CNV loss 25118596
nsv1006405 CNV loss 25217958
nsv1012126 CNV gain 25217958
nsv581670 CNV loss 21841781
nsv581671 CNV loss 21841781
nsv953775 CNV duplication 24416366

Variation tolerance for PPM1B Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPM1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1B Gene

Disorders for PPM1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPM1B Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypotonia-cystinuria syndrome
  • cystinuria with mitochondrial disease
cystinuria
  • csnu
- elite association - COSMIC cancer census association via MalaCards
Search PPM1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPM1B

Genetic Association Database (GAD)
PPM1B
Human Genome Epidemiology (HuGE) Navigator
PPM1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1B
genes like me logo Genes that share disorders with PPM1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPM1B Gene

Publications for PPM1B Gene

  1. The cloning expression and tissue distribution of human PP2Cbeta. (PMID: 9684878) Marely A.E. … Beri R.K. (FEBS Lett. 1998) 2 3 4 22 64
  2. Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation. (PMID: 16872604) Takeuchi T. … Yokosawa H. (FEBS Lett. 2006) 3 4 22 64
  3. Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms. (PMID: 10934208) Cheng A. … Solomon M.J. (J. Biol. Chem. 2000) 3 4 22 64
  4. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. (PMID: 22750291) Zhao Y. … Yang J. (Cell. Signal. 2012) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for PPM1B Gene

Sources for PPM1B Gene

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