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PPM1B Gene

protein-coding   GIFtS: 67
GCID: GC02P044395

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B

(Previous names: protein phosphatase 1B (formerly 2C), magnesium-dependent,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B1 2     Protein Phosphatase 2C1
Protein Phosphatase 1B (Formerly 2C), Magnesium-Dependent, Beta Isoform1 2     PP2C-beta-X2
Protein Phosphatase 2C Isoform Beta2 3     PP2CBETA2
PP2C-beta2 3     PPC2BETAX2
PP2CB2 3     Protein Phosphatase 1B2
EC 3.1.3.163 8     Protein Phosphatase 2C-Like Protein2
Beta Isoform1     

External Ids:    HGNC: 92761   Entrez Gene: 54952   Ensembl: ENSG000001380327   OMIM: 6037705   UniProtKB: O756883   

Export aliases for PPM1B gene to outside databases

Previous GC identifers: GC02P044394 GC02P044564 GC02P044370 GC02P044307 GC02P044132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPM1B Gene:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family
members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to
dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression
of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in
multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but
currently do not represent full-length sequences. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPM1B Gene:
PPM1B (protein phosphatase, Mg2+/Mn2+ dependent, 1B) is a protein-coding gene. Diseases associated with PPM1B include 2p21 microdeletion syndrome, and cystinuria. GO annotations related to this gene include manganese ion binding and magnesium ion binding. An important paralog of this gene is PPM1A.

UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and
PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role
in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating
IKBKB/IKKB

Gene Wiki entry for PPM1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPM1B gene promoter:
         Egr-3   AhR   RP58   Tal-1beta   Arnt   Egr-4   Egr-2   Cart-1   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPM1B promoter sequence
   Search Chromatin IP Primers for PPM1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p22.1

PPM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P044395:  view genomic region     (about GC identifiers)

Start:
44,395,108 bp from pter      End:
44,471,523 bp from pter
Size:
76,416 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688 (See protein sequence)
Recommended Name: Protein phosphatase 1B  
Size: 479 amino acids; 52643 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Subunit: Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB
1 PDB 3D structure from and Proteopedia for PPM1B:
2P8E (3D)    
Secondary accessions: Q461Q2 Q4J6C1 Q4J6C2 Q658R4 Q96ER6 Q9HAY8
Alternative splicing: 5 isoforms:  O75688-1   O75688-2   O75688-3   O75688-4   O75688-5   

Explore the universe of human proteins at neXtProt for PPM1B: NX_O75688

Explore proteomics data for PPM1B at MOPED

Post-translational modifications: 

  • Isgylation negatively regulates its activity1
  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPM1B (O75688) (see all 12)
     GDSRAVL  LPPGGGL  WDVMSNEE  KGSRDNMS 


    See PPM1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001028728.1  NP_001028729.1  NP_002697.1  NP_808907.1  NP_808908.1  

    ENSEMBL proteins: 
     ENSP00000390087   ENSP00000387287   ENSP00000282412   ENSP00000367813   ENSP00000326089  
     ENSP00000386982   ENSP00000387341  
    Reactome Protein details: O75688

    PPM1B Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for PPM1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    4 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR012911 PP2C_C
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry O75688

    ProtoNet protein and cluster: O75688

    1 Blocks protein domain: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
    Similarity: Belongs to the PP2C family


    PPM1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPM1B_HUMAN, O75688
    Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and
    PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role
    in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating
    IKBKB/IKKB
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003824catalytic activity ----
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IDA--
    GO:0005515protein binding IPI16872604
         
    PPM1B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PPM1B:
     Decreased circadian period len  Decreased focal adhesion (FA)   Increased apoptosis  Upregulation of NF-kappaB path 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppm1b):
     embryogenesis  mortality/aging  no phenotypic analysis 

    PPM1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppm1btm1.1Tamu for PPM1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPM1B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPM1B

    miRNA
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    miRTarBase miRNAs that target PPM1B:
    hsa-mir-106b-5p (MIRT044250)

    Block miRNA regulation of human, mouse, rat PPM1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPM1B (see all 46):
    hsa-miR-3664-5p hsa-miR-429 hsa-miR-570 hsa-miR-1273d hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPM1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPM1B

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    GenScript: all cDNA clones in your preferred vector (see all 5): PPM1B (NM_002706)
    Sino Biological Human cDNA Clone for PPM1B
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPM1B_HUMAN, O75688: Cytoplasm, cytosol. Membrane (By similarity). Note=Weakly associates at the membrane and
    N-myristoylation mediates the membrane localization (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016020membrane ISS--

    PPM1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPM1B About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    4Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PPM1B
        AMPK Enzyme Complex Pathway

    2 GeneGo (Thomson Reuters) Pathways for PPM1B
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for PPM1B
        MAPK signaling pathway


    1 Reactome Pathway for PPM1B
        ISG15 antiviral mechanism


    1 Kegg Pathway  (Kegg details for PPM1B):
        MAPK signaling pathway


    PPM1B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1B: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPM1B (O756881, 2, 3 ENSP000002824124) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1EP496742, 3, ENSP000003529294MINT-8387176 I2D: score=1 STRING: ENSP00000352929
    MARK3P274482, 3, ENSP000004113974MINT-8247539 I2D: score=1 STRING: ENSP00000411397
    ARRB1P494071, 3EBI-1047039,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-1047039,EBI-714559 I2D: score=1 
    ISG15P051611, 2, 3, ENSP000003686994EBI-1047039,EBI-746466 MINT-2841892 MINT-2841870 I2D: score=2 STRING: ENSP00000368699
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IMP18930133
    GO:0006499N-terminal protein myristoylation ISS--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032688negative regulation of interferon-beta production IMP--
    GO:0035970peptidyl-threonine dephosphorylation IDA--

    PPM1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPM1B

    5 HMDB Compounds for PPM1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for PPM1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 54.7 1 19294699 (1)
    serine 36 1 19294699 (1)



    PPM1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPM1B gene (5 alternative transcripts): 
    NM_001033556.1  NM_001033557.1  NM_002706.4  NM_177968.2  NM_177969.2  

    Unigene Cluster for PPM1B:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1B
    Hs.416769  [show with all ESTs]
    Unigene Representative Sequence: NM_177968
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419807 ENST00000409486 ENST00000409432(uc002rtu.3) ENST00000282412(uc002rtt.3 uc002rtv.3)
    ENST00000378551(uc002rtw.3) ENST00000378540(uc002rtx.3) ENST00000345249
    ENST00000409473 ENST00000459690 ENST00000487286 ENST00000488866 ENST00000409895(uc002rts.3)

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    hsa-miR-3664-5p hsa-miR-429 hsa-miR-570 hsa-miR-1273d hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPM1B 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 5): PPM1B (NM_002706)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PPM1B
      QuantiFast Probe-based Assays in human, mouse, rat PPM1B

    Additional mRNA sequence: 

    AF136972.1 AF294792.1 AJ005801.1 AJ271832.1 AJ271835.1 AK056009.1 AK291214.1 AL833035.1 
    BC012002.1 BC064381.1 BC115372.1 DQ023508.1 DQ023509.1 DQ023510.1 DQ023511.1 

    14 DOTS entries:

    DT.114953  DT.100790285  DT.100790287  DT.100756395  DT.95173941  DT.100790288  DT.104698  DT.100025118 
    DT.120951602  DT.95161370  DT.120951627  DT.95173938  DT.92445556  DT.95236399 

    Selected AceView cDNA sequences (see all 237):

    AA565932 AA313690 BC064381 CB161742 AV701964 CA396958 BX418214 AI039327 
    CR617365 BM786782 AW769473 AI659520 AI915874 CA449300 BU616544 AL833035 
    AJ271835 AA291248 AI701749 AV713647 AW664785 AF294792 BM466823 AA135096 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPM1B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                      -                                             
    SP2:                                      -                 -                           
    SP3:              -     -     -           -                 -                           
    SP4:                                      -                 -     -     -               
    SP5:                                -     -                 -     -     -               


    ECgene alternative splicing isoforms for PPM1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPM1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTGGAA
    PPM1B Expression
    About this image


    PPM1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    PPM1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPM1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416769

    UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
    Tissue specificity: Highly expressed in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1B: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPM1B gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppm1b1 , 5 protein phosphatase 1B, magnesium dependent, beta isoform1, 5 90.01(n)1
    91.82(a)1
      17 (55.13 cM)5
    190431  NM_001159496.11  NP_001152968.11 
     849567415 
    chicken
    (Gallus gallus)
    Aves PPM1B1 protein phosphatase, Mg2+/Mn2+ dependent, 1B 88.05(n)
    94.29(a)
      421404  NM_001031052.1  NP_001026223.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPM1B6
    protein phosphatase, Mg2+/Mn2+ dependent, 1B
    93(a)
    1 ↔ 1
    GL343231.1(2091745-2147129)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100322 Xenopus laevis transcribed sequence with moderate similarity more 80.3(n)    BU916926.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppm1ba1 protein phosphatase, Mg2+/Mn2+ dependent, 1Ba 72.31(n)
    77.34(a)
      30672  NM_131398.1  NP_571473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alph1 alphabet 54.3(n)
    54.95(a)
      43481  NM_143444.3  NP_651701.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ppm-11 ppm-1 57.66(n)
    56.08(a)
      179469  NM_001129457.2  NP_001122929.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTC36
    PTC26
    Type 2C protein phosphatase (PP2C); dephosphorylat...
    Type 2C protein phosphatase (PP2C); dephosphorylat...
    26(a)
    25(a)
    many ↔ many
    many ↔ many
    II(113762-115168) YBL056W
    V(335946-337340) YER089C


    ENSEMBL Gene Tree for PPM1B (if available)
    TreeFam Gene Tree for PPM1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPM1B gene
    PPM1A2  PPM1N2  
    3 SIMAP similar genes for PPM1B using alignment to 4 protein entries:     PPM1B_HUMAN (see all proteins):
    PPM1A    PPM1M    PPM1N

    PPM1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPM1B (see all 1682)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816391521,2
    --44263536(+) GTTCTC/GGAAGA 5 -- us2k10--------
    rs1153225371,2
    F--44263679(+) AATATG/CCTTGC 5 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1383877101,2
    --44263761(+) GTCCTA/TTTACT 5 -- us2k10--------
    rs1862147121,2
    C--44263773(+) AATTTA/GCCCTT 5 -- us2k10--------
    rs3771737271,2
    C--44263913(+) AAAAA-/AAATAT/A
    TATAT
    /TATAT
    ATATA
    15 -- us2k1 cds10--------
    rs614578511,2
    C--44263915(+) AAAAA-/TATATA 5 -- us2k10--------
    rs560812381,2
    F--44263930(+) TATATA/CTATCC 5 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1148477681,2
    C--44264045(+) CCCCAC/TCGGCC 5 -- us2k10--------
    rs1462781961,2
    --44264171(+) AATTGC/TAGTAC 5 -- us2k10--------
    rs1886234941,2
    --44264405(+) CACCTA/GTCCCA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPM1B (44395108 - 44471523 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPM1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2751893CNV Loss17911159
    nsv833936CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPM1B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPM1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603770    OMIM disorders: --

    8 diseases for PPM1B:    
    About MalaCards
    2p21 microdeletion syndrome    cystinuria    pancreatic cancer    pancreatitis
    prostate cancer    prostatitis    endotheliitis    malaria

    1 disease from the University of Copenhagen DISEASES database for PPM1B:
    Cystinuria

    PPM1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPM1B
    Human Genome Epidemiology (HuGE) Navigator: PPM1B (1 document)

    Export disorders for PPM1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPM1B gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with PPM1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning expression and tissue distribution of human PP2Cbeta. (PubMed id 9684878)1, 2, 3, 9 Marely A.E.... Beri R.K. (FEBS Lett. 1998)
    2. Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation. (PubMed id 16872604)1, 2, 9 Takeuchi T....Yokosawa H. (FEBS Lett. 2006)
    3. Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms. (PubMed id 10934208)1, 2, 9 Cheng A.... Solomon M.J. (J. Biol. Chem. 2000)
    4. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. (PubMed id 22750291)1, 2 Zhao Y....Yang J. (Cell. Signal. 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PubMed id 18930133)1, 2 Sun W....Yang J. (Cell. Signal. 2009)
    7. The 2p21 deletion syndrome: characterization of the transcription content. (PubMed id 15913950)1, 2 Parvari R....Hershkovitz E. (Genomics 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta. (PubMed id 11563908)1, 9 Seroussi E....Lavi S. (J. Mol. Biol. 2001)
    10. Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity. (PubMed id 14585847)1, 9 Prajapati S....Gaynor R.B. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5495 HGNC: 9276 AceView: PPM1B Ensembl:ENSG00000138032 euGenes: HUgn5495
    ECgene: PPM1B Kegg: 5495 H-InvDB: PPM1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPM1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPM1B gene:
    Search GeneIP for patents involving PPM1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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