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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPM1B Gene

protein-coding   GIFtS: 65
GCID: GC02P044307

protein phosphatase, Mg2+/Mn2+ dependent, 1B

(Previous names: protein phosphatase 1B (formerly 2C), magnesium-dependent,...)
 Explore 6 diseases affiliated with
PPM1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPM1B    

Aliases
for PPM1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B1 2     PP2C-Beta1
PP2CB1 2 3     EC 3.1.3.163 8
PP2CBETA1 2     PP2C-Beta-X1
PPC2BETAX1 2     Protein Phosphatase 1B2
Protein Phosphatase 1B (Formerly 2C), Magnesium-Dependent, Beta Isoform1 2     Protein Phosphatase 2C-Like Protein2
Protein Phosphatase 2C Isoform Beta2 3     

External Ids:    HGNC: 92761   Entrez Gene: 54952   Ensembl: ENSG000001380327   OMIM: 6037705   UniProtKB: O756883   

Export aliases for PPM1B gene to outside databases

Previous GC identifers: GC02P044394 GC02P044564 GC02P044370 GC02P044132


Summaries
for PPM1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPM1B:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members
are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to
dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of
this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple
transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do
not represent full-length sequences. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro

Gene Wiki entry for PPM1B


Genomic Views
for PPM1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPM1B gene promoter:
         Egr-3   AhR   RP58   Tal-1beta   Arnt   Egr-4   Egr-2   Cart-1   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPM1B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPM1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p22.1

PPM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P044307:  view genomic region     (about GC identifiers)

Start:
 44,395,108 bp from pter      End:
 44,471,523 bp from pter
Size:
 76,416 bases      Orientation:
 plus strand

Proteins
for PPM1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688 (See protein sequence)
Recommended Name: Protein phosphatase 1B  
Size: 479 amino acids; 52643 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Subunit: Monomer (By similarity). Interacts with PAK6
1 PDB 3D structure from and Proteopedia for PPM1B:
2P8E (3D)    
Secondary accessions: Q461Q2 Q4J6C1 Q4J6C2 Q658R4 Q96ER6 Q9HAY8
Alternative splicing: 5 isoforms:  O75688-1   O75688-2   O75688-3   O75688-4   O75688-5   

Explore the universe of human proteins at neXtProt for PPM1B: NX_O75688

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75688

    • 4/12 DME Specific Peptides for PPM1B (O75688) (see all 12)
     GDSRAVL  LPPGGGL  WDVMSNEE  KGSRDNMS 

    PPM1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001028728.1  NP_001028729.1  NP_002697.1  NP_808907.1  NP_808908.1  

    ENSEMBL proteins: 
     ENSP00000390087   ENSP00000387287   ENSP00000282412   ENSP00000367813   ENSP00000326089  
     ENSP00000386982   ENSP00000387341  
    Reactome Protein details: O75688
    Human Recombinant Protein Products: 
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    Uscn Proteins for PPM1B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0008287protein serine/threonine phosphatase complex ----


    PPM1B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PPM1B

    Protein Domains /
    Families
    for PPM1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPM1B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001932 PP2C-like
     IPR012911 PP2C_C
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry O75688

    ProtoNet protein and cluster: O75688

    1 Blocks protein family: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
    Similarity: Belongs to the PP2C family


    Function
    for PPM1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
    Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1B (see all 46):
    hsa-miR-3664-5p hsa-miR-429 hsa-miR-570 hsa-miR-1273d hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PPM1B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004722protein serine/threonine phosphatase activity IDA--
    GO:0005515protein binding IPI17620599
    GO:0030145manganese ion binding IEA--


    PPM1B for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for PPM1B:
     Decreased circadian period len  Decreased focal adhesion (FA)   Increased apoptosis  Upregulation of NF-kappaB path 

    Animal Models:
         Mouse knock-out Ppm1btm1.1Tamu for PPM1B
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ppm1b):
     embryogenesis  mortality/aging  no phenotypic analysis 

    PPM1B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPM1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    2Apoptosis and survival BAD phosphorylation
    		Apoptosis and survival BAD phosphorylation1.00
    		Apoptosis and survival_BAD phosphorylation0.99
    3MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    4Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		Antiviral mechanism by IFN-stimulated genes0.49
    		ISG15 antiviral mechanism0.49
    5Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PPM1B
        Apoptosis and survival BAD phosphorylation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PPM1B
        AMPK Enzyme Complex Pathway

    2 GeneGo (Thomson Reuters) Pathways for PPM1B
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for PPM1B 
        MAPK signaling pathway

    5        Reactome Pathways for PPM1B
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    Interferon Signaling
    ISG15 antiviral mechanism
    Immune System


    1         Kegg Pathway  (Kegg details for PPM1B):
        MAPK signaling pathway


    PPM1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/105 Interacting proteins for PPM1B (O756881, 2, 3 ENSP000002824124) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274482, 3, ENSP000004113974MINT-8247539 I2D: score=1 STRING: ENSP00000411397
    ARRB1P494071, 3EBI-1047039,EBI-2561130 I2D: score=1 
    ARRB2P321211, 3EBI-1047039,EBI-714559 I2D: score=1 
    CSNK1EP496742, 3MINT-8387176 I2D: score=1 
    ISG15P051612, 3, ENSP000003686994MINT-2841892 MINT-2841870 I2D: score=2 STRING: ENSP00000368699
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS9684878
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035970peptidyl-threonine dephosphorylation IDA--


    PPM1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPM1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPM1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPM1B

    5 HMDB Compounds for PPM1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    2 Novoseek chemical compound relationships for PPM1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 54.7 1 19294699 (1)
    serine 36 1 19294699 (1)

    Search CenterWatch for drugs/clinical trials and news about PPM1B 

    Transcripts
    for PPM1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPM1B gene (5 alternative transcripts): 
    NM_001033556.1  NM_001033557.1  NM_002706.4  NM_177968.2  NM_177969.2  

    Unigene Cluster for PPM1B:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1B
    Hs.416769  [show with all ESTs]
    Unigene Representative Sequence: NM_177968
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419807 ENST00000409486 ENST00000409432(uc002rtu.3) ENST00000282412(uc002rtt.3 uc002rtv.3)
    ENST00000378551(uc002rtw.3) ENST00000378540(uc002rtx.3) ENST00000345249
    ENST00000409473 ENST00000459690 ENST00000487286 ENST00000488866 ENST00000409895(uc002rts.3)


    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1B (see all 46):
    hsa-miR-3664-5p hsa-miR-429 hsa-miR-570 hsa-miR-1273d hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PPM1B 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF136972.1 AF294792.1 AJ005801.1 AJ271832.1 AJ271835.1 AK056009.1 AK291214.1 AL833035.1 
    BC012002.1 BC064381.1 BC115372.1 DQ023508.1 DQ023509.1 DQ023510.1 DQ023511.1 

    14 DOTS entries:

    DT.114953  DT.100790285  DT.100790287  DT.100756395  DT.120951602  DT.95173941  DT.100790288  DT.104698 
    DT.100025118  DT.95161370  DT.120951627  DT.95173938  DT.92445556  DT.95236399 

    24/237 AceView cDNA sequences (see all 237):

    BX418214 BG150150 AI701749 AA135096 AA313690 CB161742 CR617365 AV701964 
    AI039327 AA992560 AW074517 AW664785 AA465249 BI439590 CA396958 BC064381 
    BU175702 BI491930 BE222028 AW769473 AI659520 AI915874 BM786782 AA179747 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPM1B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                      -                                             
    SP2:                                      -                 -                           
    SP3:              -     -     -           -                 -                           
    SP4:                                      -                 -     -     -               
    SP5:                                -     -                 -     -     -               


    ECgene alternative splicing isoforms for PPM1B

    Expression
    for PPM1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPM1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGTGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PPM1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPM1B

    SOURCE GeneReport for Unigene cluster: Hs.416769

    UniProtKB/Swiss-Prot: PPM1B_HUMAN, O75688
    Tissue specificity: Highly expressed in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including PPM1B: 
              Protein Phosphatases in human mouse rat

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    In Situ
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    Orthologs
    for PPM1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPM1B gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PPM1B1 protein phosphatase, Mg2+/Mn2+ dependent, 1B 88.05(n)
    94.29(a)    		   421404  NM_001031052.1  NP_001026223.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPM1B6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343231.1(2121748-2145828)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.100322 Xenopus laevis transcribed sequence with moderate similarity more 80.3(n)    BU916926.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ppm1ba1 protein phosphatase, Mg2+/Mn2+ dependent, 1Ba 72.31(n)
    77.34(a)    		   30672  NM_131398.1  NP_571473.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta alph1 alphabet 54.4(n)
    54.67(a)    		   43481  NM_143444.3  NP_651701.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ppm-11 Protein PPM-1 55.73(n)
    52.01(a)    		   179469  NM_001028671.2  NP_001023842.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G514706
    AT2G337006
    (see all 8)    		 putative protein phosphatase 2C 27
    (see all 8)    		 24(a)
    24(a)
    (see all 8)    		 possible ortholog
    possible ortholog
    (see all 8)    		 3(19097787-19099275)
    2(14253424-14255993)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 10)    		 protein phosphatase 2C, putative, expressed
    (see all 10)    		 26(a)
    26(a)
    (see all 10)    		 possible ortholog
    possible ortholog
    (see all 10)    		 10(21054681-21058573)
    2(34020404-34024433)


    ENSEMBL Gene Tree for PPM1B (if available)
    TreeFam Gene Tree for PPM1B (if available) 

    Paralogs
    for PPM1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPM1B gene
    PPM1D2  PPM1A2  PPM1N2  PPM1G2  
    3 SIMAP similar genes for PPM1B using alignment to 4 protein entries:     PPM1B_HUMAN (see all proteins):
    PPM1A    PPM1M    PPM1N

    PPM1B for paralogs           About GeneDecksing



    Genomic Variants
    for PPM1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1357 NCBI SNPs in PPM1B are shown (see all 1357)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1816391521,2
    		--44394017(+) GTTCTC/GGAAGA 5 -- us2k10--------
    rs1153225371,2
    		F,--44394160(+) AATATG/CCTTGC 5 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1383877101,2
    		--44394242(+) GTCCTA/TTTACT 5 -- us2k10--------
    rs1862147121,2
    		--44394254(+) AATTTA/GCCCTT 5 -- us2k10--------
    rs614578511,2
    		C,--44394396(+) AAAAA-/TATATA 5 -- us2k10--------
    rs560812381,2
    		F,--44394411(+) TATATA/CTATCC 5 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1148477681,2
    		C,--44394526(+) CCCCAC/TCGGCC 5 -- us2k10--------
    rs1462781961,2
    		--44394652(+) AATTGC/TAGTAC 5 -- us2k10--------
    rs1886234941,2
    		--44394886(+) CACCTA/GTCCCA 5 -- us2k10--------
    rs1161810151,2
    		F,--44394935(+) ATTTCC/TCGCCC 5 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for PPM1B (44395108 - 44471523 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PPM1B
         1 CNV: 8943

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    Disorders / Diseases
    for PPM1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPM1B for disorders           About GeneDecksing

    OMIM gene information: 603770    OMIM disorders: --

    6 diseases for PPM1B:    About MalaCards
    cystinuria    prostate cancer    prostatitis    carcinoma
    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for PPM1B:
    Cystinuria
    Human Genome Epidemiology (HuGE) Navigator: PPM1B (1 document)

    Export disorders for PPM1B gene to outside databases

    Publications
    for PPM1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPM1B gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with PPM1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning expression and tissue distribution of human PP2Cbeta. (PubMed id 9684878)1, 2, 3, 9 Marely A.E.... Beri R.K. (1998)
    2. Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms. (PubMed id 10934208)1, 2, 9 Cheng A.... Solomon M.J. (2000)
    3. The 2p21 deletion syndrome: characterization of the transcription content. (PubMed id 15913950)1, 2 Parvari R....Hershkovitz E. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta. (PubMed id 11563908)1, 9 Seroussi E....Lavi S. (2001)
    6. Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity. (PubMed id 14585847)1, 9 Prajapati S....Gaynor R.B. (2004)
    7. A recessive contiguous gene deletion of chromosome 2p 16 associated with cystinuria and a mitochondrial disease. (PubMed id 11524703)1, 9 Parvari R....Hershkovitz E. (2001)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Functional interactions between erythroid Kruppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cb. (PubMed id 22393050)1 Yien Y.Y. and Bieker J.J. (2012)
    10. PPM1B negatively regulates antiviral response via deph osphorylating TBK1. (PubMed id 22750291)1 Zhao Y....Yang J. (2012)

    External Searches for PPM1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPM1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5495 HGNC: 9276 AceView: PPM1B Ensembl:ENSG00000138032 euGenes: HUgn5495
    ECgene: PPM1B Kegg: 5495 H-InvDB: PPM1B

    Other Databases showing PPM1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPM1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPM1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PPM1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPM1B gene:
    Search GeneIP for patents involving PPM1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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