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Aliases for PPM1A Gene

Aliases for PPM1A Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1A 2 3 5
  • Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform 2 3
  • EC 3.1.3.16 4 58
  • PP2C-ALPHA 3 4
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 2
  • Protein Phosphatase 2C, Alpha Isoform 2
  • Protein Phosphatase 2C Isoform Alpha 4
  • Protein Phosphatase 1A 3
  • Protein Phosphatase IA 4
  • Phosphatase 2C Alpha 2
  • PP2Calpha 3
  • PPPM1A 4
  • PP2CA 3

External Ids for PPM1A Gene

Previous GeneCards Identifiers for PPM1A Gene

  • GC14P058042
  • GC14P054506
  • GC14P058702
  • GC14P059782
  • GC14P060712
  • GC14P040876

Summaries for PPM1A Gene

Entrez Gene Summary for PPM1A Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1A Gene

PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent 1A) is a Protein Coding gene. Among its related pathways are Regulation of CFTR activity (norm and CF) and RET signaling. GO annotations related to this gene include signal transducer activity and protein C-terminus binding. An important paralog of this gene is PPM1B.

UniProtKB/Swiss-Prot for PPM1A Gene

  • Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Gene Wiki entry for PPM1A Gene

Additional gene information for PPM1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1A Gene

Genomics for PPM1A Gene

Regulatory Elements for PPM1A Gene

Enhancers for PPM1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H060247 1.4 ENCODE dbSUPER 18.9 +4.1 4055 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 PPM1A TRMT5 LOC101927702 GC14P060294
GH14H060277 0.8 Ensembl ENCODE 31.6 +32.7 32674 1 BCOR ZNF217 ZNF3 ZMYM3 ETS1 PPM1A LOC101927702 GC14P060294
GH14H060178 1.1 Ensembl ENCODE dbSUPER 18.5 -66.0 -66001 1 PKNOX1 JUNB BATF ZNF316 NFE2 RUNX3 MAFK PRDM1 NFE2L2 PPM1A RTN1 LOC101927702 PCNX4 C14orf39 GC14P060180 RPL17P2
GH14H060330 1.4 Ensembl ENCODE dbSUPER 10.8 +85.9 85915 1 PKNOX1 NFIB ARID4B SIN3A DMAP1 BATF RAD21 YY1 ZNF143 ATF7 L3HYPDH C14orf39 PCNX4 SCOCP1 LOC101927702 PPM1A TRMT5 GC14P060353 LINC02322
GH14H060183 1.3 Ensembl ENCODE dbSUPER 11.2 -61.6 -61576 1 TBP CTCF PKNOX1 RB1 RAD21 RFX5 SMC3 ZNF143 ATF7 PRDM10 RTN1 LOC101927702 PPM1A C14orf39 GC14P060180 RPL17P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPM1A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPM1A gene promoter:

Genomic Location for PPM1A Gene

Chromosome:
14
Start:
60,245,752 bp from pter
End:
60,299,087 bp from pter
Size:
53,336 bases
Orientation:
Plus strand

Genomic View for PPM1A Gene

Genes around PPM1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1A Gene

Proteins for PPM1A Gene

  • Protein details for PPM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35813-PPM1A_HUMAN
    Recommended name:
    Protein phosphatase 1A
    Protein Accession:
    P35813
    Secondary Accessions:
    • B5BU11
    • J3KNM0
    • O75551

    Protein attributes for PPM1A Gene

    Size:
    382 amino acids
    Molecular mass:
    42448 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.

    Three dimensional structures from OCA and Proteopedia for PPM1A Gene

    Alternative splice isoforms for PPM1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1A Gene

Selected DME Specific Peptides for PPM1A Gene

P35813:
  • SVENVKNGIRTGFL
  • EKERIQNAGGSVMIQRVNGSLAVSRALGD
  • GKGPTEQLVSPEPEV
  • YFINCGDSR
  • DQFIILA
  • DRSGSTAVGV
  • KRNVIEAVY
  • KGSRDNMS
  • DNMSVIL
  • GLSSMQGWR
  • WSFFAVYDGHAGS

Post-translational modifications for PPM1A Gene

  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
  • Ubiquitination at posLast=278278
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PPM1A (PP2C alpha/PPM1A)
  • Cell Signaling Technology (CST) Antibodies for PPM1A (PPPM1A)

Assay Products

  • Cloud-Clone Corp. Assay Kits for PPM1A

Domains & Families for PPM1A Gene

Gene Families for PPM1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPM1A Gene

Suggested Antigen Peptide Sequences for PPM1A Gene

Graphical View of Domain Structure for InterPro Entry

P35813

UniProtKB/Swiss-Prot:

PPM1A_HUMAN :
  • Belongs to the PP2C family.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1A: view

Function for PPM1A Gene

Molecular function for PPM1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Enzyme Numbers (IUBMB) for PPM1A Gene

Phenotypes From GWAS Catalog for PPM1A Gene

Gene Ontology (GO) - Molecular Function for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,TAS --
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with PPM1A: view
genes like me logo Genes that share phenotypes with PPM1A: view

Animal Models for PPM1A Gene

MGI Knock Outs for PPM1A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPM1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPM1A Gene

Localization for PPM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1A Gene

Nucleus. Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250 UniProtKB:P49443}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16751101
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PPM1A: view

Pathways & Interactions for PPM1A Gene

genes like me logo Genes that share pathways with PPM1A: view

SIGNOR curated interactions for PPM1A Gene

Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006470 protein dephosphorylation IMP,IEA 18930133
GO:0006499 N-terminal protein myristoylation ISS --
GO:0007050 cell cycle arrest TAS --
GO:0010991 negative regulation of SMAD protein complex assembly IDA 16751101
genes like me logo Genes that share ontologies with PPM1A: view

Drugs & Compounds for PPM1A Gene

(7) Drugs for PPM1A Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for PPM1A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PPM1A: view

Transcripts for PPM1A Gene

Unigene Clusters for PPM1A Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPM1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6: - - - -

Relevant External Links for PPM1A Gene

GeneLoc Exon Structure for
PPM1A
ECgene alternative splicing isoforms for
PPM1A

Expression for PPM1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1A Gene

Protein differential expression in normal tissues from HIPED for PPM1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3) and Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPM1A Gene



Protein tissue co-expression partners for PPM1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1A Gene:

PPM1A

SOURCE GeneReport for Unigene cluster for PPM1A Gene:

Hs.130036

Evidence on tissue expression from TISSUES for PPM1A Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Lung(4.3)
  • Nervous system(3.6)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PPM1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1A Gene

Orthologs for PPM1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1A 33 34
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia PPM1A 33 34
  • 96.42 (n)
-- 34
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PPM1A 33 34
  • 94.29 (n)
oppossum
(Monodelphis domestica)
Mammalia PPM1A 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1a 33
  • 93.63 (n)
mouse
(Mus musculus)
Mammalia Ppm1a 33 16 34
  • 93.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1A 34
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1A 33 34
  • 88.13 (n)
lizard
(Anolis carolinensis)
Reptilia PPM1A 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1a 33
  • 83.77 (n)
Str.7047 33
African clawed frog
(Xenopus laevis)
Amphibia ppm1a-prov 33
zebrafish
(Danio rerio)
Actinopterygii ppm1aa 33 34
  • 73.33 (n)
ppm1ab 34
  • 73 (a)
OneToMany
Dr.11472 33
fruit fly
(Drosophila melanogaster)
Insecta CG1906 35
  • 52 (a)
alph 34
  • 52 (a)
ManyToMany
CG6036 35 34
  • 50 (a)
CG12169 35
  • 41 (a)
CG17746 35
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea F25D1.1 35
  • 48 (a)
T23F11.1 35
  • 43 (a)
ppm-1 34
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC2 34 36
  • 23 (a)
ManyToMany
PTC3 34
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Species where no ortholog for PPM1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1A Gene

ENSEMBL:
Gene Tree for PPM1A (if available)
TreeFam:
Gene Tree for PPM1A (if available)

Paralogs for PPM1A Gene

Paralogs for PPM1A Gene

(2) SIMAP similar genes for PPM1A Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PPM1A Gene

genes like me logo Genes that share paralogs with PPM1A: view

Variants for PPM1A Gene

Sequence variations from dbSNP and Humsavar for PPM1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000043437 -- 60,271,547(+) TGATG(A/C)CATGG intron-variant
rs1000075120 -- 60,271,807(+) TTCCA(C/T)CCACA intron-variant
rs1000304460 -- 60,271,809(+) CCATC(C/T)ACATG intron-variant
rs1000306120 -- 60,248,313(+) ATCCT(C/G)TTCCC intron-variant, upstream-variant-2KB
rs1000372745 -- 60,267,637(+) ATGTT(C/T)CCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1A Gene

Variant ID Type Subtype PubMed ID
esv2256431 CNV deletion 18987734
esv2453133 CNV insertion 19546169
esv2748750 CNV deletion 23290073
esv3304133 CNV mobile element insertion 20981092
esv3309874 CNV mobile element insertion 20981092
esv3379472 CNV insertion 20981092
esv3417176 CNV insertion 20981092
nsv1071150 CNV deletion 25765185
nsv1129557 CNV tandem duplication 24896259
nsv1136179 CNV deletion 24896259
nsv472366 CNV novel sequence insertion 20440878
nsv832812 CNV loss 17160897
nsv952845 CNV duplication 24416366
nsv983969 CNV duplication 23825009

Variation tolerance for PPM1A Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPM1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1A Gene

Disorders for PPM1A Gene

Relevant External Links for PPM1A

Genetic Association Database (GAD)
PPM1A
Human Genome Epidemiology (HuGE) Navigator
PPM1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1A

No disorders were found for PPM1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1A Gene

Publications for PPM1A Gene

  1. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. (PMID: 1311954) Mann DJ … Cohen PT (Biochimica et biophysica acta 1992) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PMID: 18930133) Sun W … Yang J (Cellular signalling 2009) 3 4 60
  4. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. (PMID: 19404668) Zhang B … Wang H (Histochemistry and cell biology 2009) 3 22 60
  5. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. (PMID: 16751101) Lin X … Feng XH (Cell 2006) 3 4 60

Products for PPM1A Gene

Sources for PPM1A Gene

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