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PPM1A Gene

protein-coding   GIFtS: 71
GCID: GC14P060712

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A

(Previous names: protein phosphatase 1A (formerly 2C), magnesium-dependent,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A1 2     PP2CA2
Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform1 2     PP2Calpha2
EC 3.1.3.163 8     Protein Phosphatase 1A2
Alpha Isoform1     PP2C-alpha3
Phosphatase 2C Alpha1     PPPM1A3
Protein Phosphatase 2C1     Protein Phosphatase 2C Isoform Alpha3
PP2C-ALPHA2     Protein Phosphatase IA3

External Ids:    HGNC: 92751   Entrez Gene: 54942   Ensembl: ENSG000001006147   OMIM: 6061085   UniProtKB: P358133   

Export aliases for PPM1A gene to outside databases

Previous GC identifers: GC14P058042 GC14P054506 GC14P058702 GC14P059782 GC14P040876


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPM1A Gene:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family
members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates,
and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the
activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also
dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this
phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M
cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have
been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPM1A Gene:
PPM1A (protein phosphatase, Mg2+/Mn2+ dependent, 1A) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and signal transducer activity. An important paralog of this gene is PPM1B.

UniProtKB/Swiss-Prot: PPM1A_HUMAN, P35813
Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2
and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the
TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of
TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB

Gene Wiki entry for PPM1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPM1A gene promoter:
         STAT5B   p53   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPM1A promoter sequence
   Search Chromatin IP Primers for PPM1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPM1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

PPM1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P060712:  view genomic region     (about GC identifiers)

Start:
60,712,470 bp from pter      End:
60,765,805 bp from pter
Size:
53,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPM1A_HUMAN, P35813 (See protein sequence)
Recommended Name: Protein phosphatase 1A  
Size: 382 amino acids; 42448 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit
Subunit: Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif
resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated
signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in
disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling.
Interacts with the phosphorylated form of IKBKB/IKKB
6 PDB 3D structures from and Proteopedia for PPM1A:
1A6Q (3D)        3FXJ (3D)        3FXK (3D)        3FXL (3D)        3FXM (3D)        3FXO (3D)    
Secondary accessions: B5BU11 J3KNM0 O75551
Alternative splicing: 3 isoforms:  P35813-1   P35813-2   P35813-3   (No experimental confirmation available. Ref.3 (AK097843) sequence is in conflict in position: 54:Q->R)

Explore the universe of human proteins at neXtProt for PPM1A: NX_P35813

Explore proteomics data for PPM1A at MOPED

Post-translational modifications: 

  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation (By similarity)1
  • Ubiquitination2 at Lys278
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPM1A (P35813) (see all 11)
     DNMSVIL  DQFIILA  KGSRDNMS  GLSSMQGWR 


    See PPM1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_066283.1  NP_808820.1  NP_808821.2  

    ENSEMBL proteins: 
     ENSP00000327255   ENSP00000437200   ENSP00000436445   ENSP00000378514   ENSP00000314850  
     ENSP00000431453   ENSP00000435398   ENSP00000435575   ENSP00000432966  
    Reactome Protein details: P35813

    PPM1A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PPM1A
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    Novus Biologicals PPM1A Proteins
    Novus Biologicals PPM1A Lysates
    Sino Biological Recombinant Protein for PPM1A
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    ProSpec Recombinant Protein for PPM1A
    Cloud-Clone Corp. Proteins for PPM1A

     
    Search eBioscience for Proteins for PPM1A 

     
    antibodies-online proteins for PPM1A (12 products) 

     
    antibodies-online peptides for PPM1A

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    Abcam antibodies for PPM1A (P35813, O75688)
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    antibodies-online antibodies for PPM1A (104 products) 

    PPM1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for PPM1A (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    4 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR012911 PP2C_C
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry P35813

    ProtoNet protein and cluster: P35813

    1 Blocks protein domain: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: PPM1A_HUMAN, P35813
    Similarity: Belongs to the PP2C family


    Find genes that share domains with PPM1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPM1A_HUMAN, P35813
    Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2
    and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the
    TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of
    TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003824catalytic activity ----
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity TAS--
    GO:0004871signal transducer activity IMP12761501
         
    Find genes that share ontologies with PPM1A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPM1A:
     Decreased focal adhesion (FA)  

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppm1a):
     homeostasis/metabolism  integument 

    Find genes that share phenotypes with PPM1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppm1atm1.1Xya for PPM1A

       genOway: Develop your customized and physiologically relevant rodent model for PPM1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPM1A:
    hsa-mir-484 (MIRT041899), hsa-mir-377-3p (MIRT000990), hsa-mir-99a-5p (MIRT048669), hsa-mir-192-5p (MIRT026486), hsa-mir-23b-3p (MIRT046263)

    Block miRNA regulation of human, mouse, rat PPM1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPM1A (see all 139):
    hsa-miR-146a hsa-miR-106a hsa-miR-1245 hsa-miR-3162-5p hsa-miR-761 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-519e
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): PPM1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPM1A
    Predesigned siRNA for gene silencing in human, mouse, rat PPM1A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): PPM1A (NM_177951)
    Sino Biological Human cDNA Clone for PPM1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPM1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPM1A_HUMAN, P35813: Nucleus. Cytoplasm, cytosol. Membrane (By similarity). Note=Weakly associates at the
    membrane and N-myristoylation mediates the membrane localization (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16751101
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005891voltage-gated calcium channel complex IEA--
    GO:0016020membrane ISS--

    Find genes that share ontologies with PPM1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPM1A About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    3Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with PPM1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PPM1A
        AMPK Enzyme Complex Pathway

    3 Cell Signaling Technology (CST) Pathways for PPM1A
        Wnt / Hedgehog / Notch
    Phosphatases
    MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for PPM1A
        Apoptosis and survival BAD phosphorylation
    Regulation of CFTR activity (norm and CF)

    3 BioSystems Pathways for PPM1A
        MAPK signaling pathway
    BMP receptor signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling


    2 Reactome Pathways for PPM1A
        Downregulation of SMAD2/3:SMAD4 transcriptional activity
    Regulation of AMPK activity via LKB1


    1 Kegg Pathway  (Kegg details for PPM1A):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1A: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPM1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPM1A (P358131, 2, 3 ENSP000003272554) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056552, 3, ENSP000003316024MINT-8387176 I2D: score=2 STRING: ENSP00000331602
    SMAD2Q157961, 3, ENSP000002621604EBI-989143,EBI-1040141 I2D: score=1 STRING: ENSP00000262160
    ARRB1P494071, 3EBI-989143,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-989143,EBI-714559 I2D: score=1 
    AXIN1O151691, 2, 3, ENSP000002623204EBI-989143,EBI-710484 MINT-8284998 MINT-8277668 MINT-8277635 MINT-8285031 MINT-8277609 MINT-8285013 I2D: score=1 STRING: ENSP00000262320
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006470protein dephosphorylation IMP18930133
    GO:0006499N-terminal protein myristoylation ISS--

    Find genes that share ontologies with PPM1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPM1A

    5 HMDB Compounds for PPM1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for PPM1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 52 1 17073441 (1)
    manganese 48.2 1 16879102 (1)
    serine 39.1 1 17073441 (1)



    Find genes that share compounds with PPM1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPM1A gene (3 alternative transcripts): 
    NM_021003.4  NM_177951.2  NM_177952.2  

    Unigene Cluster for PPM1A:

    Protein phosphatase, Mg2+/Mn2+ dependent, 1A
    Hs.130036  [show with all ESTs]
    Unigene Representative Sequence: NM_021003
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325642 ENST00000531143 ENST00000532036 ENST00000395076(uc001xew.4 uc010apn.3 uc001xey.4)
    ENST00000325658(uc001xex.4) ENST00000528241 ENST00000525399 ENST00000531937
    ENST00000529574
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPM1A (see all 139):
    hsa-miR-146a hsa-miR-106a hsa-miR-1245 hsa-miR-3162-5p hsa-miR-761 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-519e
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPM1A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPM1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPM1A
      QuantiTect SYBR Green Assays in human, mouse, rat PPM1A
      QuantiFast Probe-based Assays in human, mouse, rat PPM1A

    Additional mRNA sequence: 

    AB451247.1 AB451371.1 AF070670.1 AK097843.1 AK124299.1 AK308225.1 AK313337.1 AY236965.1 
    BC026691.1 BC063243.1 S87759.1 

    12 DOTS entries:

    DT.100818830  DT.113018  DT.95268553  DT.100818823  DT.120775109  DT.100718967  DT.100677550  DT.120775110 
    DT.40113944  DT.92430782  DT.40128061  DT.99953812 

    Selected AceView cDNA sequences (see all 253):

    BM782609 AI289045 BQ717594 CA391124 AA370750 BM476428 CA944887 AV648740 
    BM698645 BI491739 AA811003 CA429296 BG941880 AA370585 BC063243 CB962920 
    BM463472 AI669598 NM_177952 CD678634 CR610726 BX333967 NM_021003 BM724194 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPM1A (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:        -     -     -     -     -     -     -     -     -                             -                     
    SP2:                    -     -     -     -     -     -     -                             -                     
    SP3:                                -     -     -     -     -                                                   
    SP4:                                                                                                            
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for PPM1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPM1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGGCTGGG
    PPM1A Expression
    About this image


    PPM1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PPM1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPM1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130036
        Pathway & Disease-focused RT2 Profiler PCR Array including PPM1A: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPM1A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppm1a1 , 5 protein phosphatase 1A, magnesium dependent, alpha more1, 5 93.54(n)1
    98.17(a)1
      12 (30.26 cM)5
    190421  NM_008910.31  NP_032936.11 
     727612115 
    chicken
    (Gallus gallus)
    Aves PPM1A1 protein phosphatase, Mg2+/Mn2+ dependent, 1A 88.13(n)
    93.98(a)
      423525  XM_421422.4  XP_421422.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPM1A6
    protein phosphatase, Mg2+/Mn2+ dependent, 1A
    91(a)
    1 ↔ 1
    GL343261.1(1089852-1127193)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppm1a-prov2 protein phosphatase 1A (formerly 2C), magnesium-dependent, more 83.74(n)    BC042302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114722 Transcribed sequence with moderate similarity to protein more 75.27(n)    57095328 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19063 protein amino acid dephosphorylation
    protein serine/threonine more
    52(a)
    (best of 4)
      99B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F25D1.13 protein phosphatase 48(a)
    (best of 2)
      V(10535971-10538573)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTC2(YER089C)4 Type 2C protein phosphatase (PP2C); dephosphorylates more   --   5(337340-335946) 856823  NP_011013.1 


    ENSEMBL Gene Tree for PPM1A (if available)
    TreeFam Gene Tree for PPM1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPM1A gene
    PPM1B2  PPM1N2  
    2 SIMAP similar genes for PPM1A using alignment to 8 protein entries:     PPM1A_HUMAN (see all proteins):
    PPM1B    PPM1N

    Find genes that share paralogs with PPM1A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PPM1A
    PGOHUM00000249256


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPM1A (see all 1017)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838937501,2
    --41694974(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1424230721,2
    --41695188(+) CTCCAC/TACCAC 1 -- us2k10--------
    rs2013073651,2
    C--41695596(+) GACAG-/TTTAAAC 1 -- us2k10--------
    rs1890604811,2
    --41695631(+) GCCCAC/TTCAAA 1 -- us2k10--------
    rs3699421611,2
    C--41695799(+) AGGTG-/TTTTTT 1 -- us2k10--------
    rs1513240291,2
    C--41695850(+) CCCACC/TGCAAC 1 -- us2k10--------
    rs1156326851,2
    F--41695934(+) CAGGCG/ATGTGC 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs116269921,2
    C,F,A,H--41695973(+) AGTAGC/AGACGG 1 -- us2k19Minor allele frequency- A:0.31NA WA CSA 16
    rs1161698571,2
    C,F--41696172(+) TACCCG/ATGCAC 1 -- us2k12Minor allele frequency- A:0.01WA NA 238
    rs1814186131,2
    --41696236(+) ACTCTC/GGAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPM1A (60712470 - 60765805 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PPM1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748750CNV Deletion23290073
    esv2256431CNV Deletion18987734
    esv2453133CNV Insertion19546169
    esv274146CNV Insertion20981092
    esv268412CNV Insertion20981092
    nsv832812CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPM1A
    DNA2.0 Custom Variant and Variant Library Synthesis for PPM1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606108    OMIM disorders: --


    Find genes that share disorders with PPM1A           About GenesLikeMe

    1 Novoseek inferred disease relationship for PPM1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16509582 (1)

    Genetic Association Database (GAD): PPM1A
    Human Genome Epidemiology (HuGE) Navigator: PPM1A (2 documents)

    Export disorders for PPM1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPM1A gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with PPM1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. (PubMed id 1311954)1, 2, 3, 9 Mann D.J.... Cohen P.T.W. (Biochim. Biophys. Acta 1992)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PubMed id 18930133)1, 2 Sun W....Yang J. (Cell. Signal. 2009)
    4. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. (PubMed id 16751101)1, 2 Lin X....Feng X.H. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways. (PubMed id 9707433)1, 2 Takekawa M.... Saito H. (EMBO J. 1998)
    8. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0-A resolution. (PubMed id 9003755)1, 2 Das A.K.... Barford D. (EMBO J. 1996)
    9. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. (PubMed id 12514180)1, 9 Ofek P....Lavi S. (J. Biol. Chem. 2003)
    10. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. (PubMed id 19404668)1, 9 Zhang B....Wang H. (Histochem. Cell Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5494 HGNC: 9275 AceView: PPM1A Ensembl:ENSG00000100614 euGenes: HUgn5494
    ECgene: PPM1A Kegg: 5494 H-InvDB: PPM1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPM1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPM1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPM1A gene:
    Search GeneIP for patents involving PPM1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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