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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPM1A Gene

protein-coding GIFtS: 69
GCID: GC14P060712

protein phosphatase, Mg2+/Mn2+ dependent, 1A

(Previous names: protein phosphatase 1A (formerly 2C), magnesium-dependent,...)

Explore 5 diseases affiliated with
PPM1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A¹ ²		PP2C-ALPHA²
PP2CA¹ ²		Protein Phosphatase 1A²
PP2Calpha¹ ²		PP2C-Alpha¹
Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform¹ ²		PPPM1A³
EC 3.1.3.16³ ⁸		Protein Phosphatase 2C Isoform Alpha³
MGC9201¹		Protein Phosphatase IA³

External Ids:	HGNC: 9275¹	Entrez Gene: 5494²	Ensembl: ENSG00000100614⁷	OMIM: 606108⁵	UniProtKB: P35813³

Export aliases for PPM1A gene to outside databases

Previous GC identifers: GC14P058042 GC14P054506 GC14P058702 GC14P059782 GC14P040876

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPM1A:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members

are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and

negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the

activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate

cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is

reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and

apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPM1A_HUMAN, P35813

Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and

SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the

TGF-beta-mediated signaling

Gene Wiki entry for PPM1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPM1A gene promoter:
STAT5B p53 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPM1A promoter sequence

Search SABiosciences Chromatin IP Primers for PPM1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPM1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q23.1

PPM1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPM1A gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P060712: view genomic region (about GC identifiers)

Start:	60,712,470 bp from pter	End:	60,765,805 bp from pter
Size:	53,336 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPM1A_HUMAN, P35813 (See protein sequence)

Recommended Name: Protein phosphatase 1A

Size: 382 amino acids; 42448 Da

Cofactor: Binds 2 magnesium or manganese ions per subunit

Subunit: Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in

disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling.

Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of

the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling

Subcellular location: Nucleus

6 PDB 3D structures from and Proteopedia for PPM1A:

1A6Q (3D)

3FXJ (3D)

3FXK (3D)

3FXL (3D)

3FXM (3D)

3FXO (3D)

Secondary accessions: B5BU11 J3KNM0 O75551

Alternative splicing: 3 isoforms: P35813-1 P35813-2 P35813-3 (No experimental confirmation available. Ref.3 (AK097843) sequence is in conflict in position: 54:Q->R)

Explore the universe of human proteins at neXtProt for PPM1A: NX_P35813

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35813

4/11 DME Specific Peptides for PPM1A (P35813) (see all 11)

DNMSVIL

DQFIILA

KGSRDNMS

GLSSMQGWR

PPM1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_066283.1 NP_808820.1 NP_808821.2

ENSEMBL proteins:

ENSP00000327255 ENSP00000437200 ENSP00000436445 ENSP00000378514 ENSP00000314850

ENSP00000431453 ENSP00000435398 ENSP00000435575 ENSP00000432966

Reactome Protein details: P35813
Human Recombinant Protein Products for PPM1A:

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	Uscn Proteins for PPM1A

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	16751101
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005891	voltage-gated calcium channel complex	--	--

PPM1A for ontologies About GeneDecksing

PPM1A Antibody Products:

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	Uscn ELISAs and CLIAs for PPM1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPM1A for domains About GeneDecksing

4 InterPro domains/families:

IPR001932 PP2C-like

IPR012911 PP2C_C

IPR000222 PP2C_Mn2_Asp60_BS

IPR015655 Protein_Pase_2C

Graphical View of Domain Structure for InterPro Entry P35813

ProtoNet protein and cluster: P35813

1 Blocks protein family: IPB000222 Protein phosphatase 2C subfamily

UniProtKB/Swiss-Prot: PPM1A_HUMAN, P35813

Similarity: Belongs to the PP2C family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PPM1A_HUMAN, P35813

Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and

SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the

TGF-beta-mediated signaling

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Enzyme Number (IUBMB): EC 3.1.3.16¹ ²

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0003824	catalytic activity	--	--
GO:0004721	phosphoprotein phosphatase activity	--	--
GO:0004722	protein serine/threonine phosphatase activity	TAS	--
GO:0004871	signal transducer activity	IMP	12761501

PPM1A for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PPM1A:

Decreased focal adhesion (FA)

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ppm1a):

homeostasis/metabolism

integument

PPM1A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ppm1a^tm1.1Xya for PPM1A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PPM1A

miRNA Products:		miRTarBase miRNAs that target PPM1A: hsa-mir-377 (MIRT000990)

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		8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1A (see all 139):
		hsa-miR-146a hsa-miR-106a hsa-miR-1245 hsa-miR-3162-5p hsa-miR-761 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-519e

		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): PPM1A 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.56
	Signaling by TGF-beta Receptor Complex	0.61

Energy dependent regulation of mTOR by LKB1-AMPK

Energy dependent regulation of mTOR by LKB1-AMPK

1.00

Regulation of AMPK activity via LKB1

0.82

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Apoptosis and survival BAD phosphorylation

Apoptosis and survival BAD phosphorylation

1.00

Apoptosis and survival_BAD phosphorylation

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PPM1A

Apoptosis and survival BAD phosphorylation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PPM1A

AMPK Enzyme Complex Pathway

3 Cell Signaling Technology (CST) Pathways for PPM1A

	Wnt / Hedgehog / Notch
	Phosphatases
	MAP Kinase Signaling

2 GeneGo (Thomson Reuters) Pathways for PPM1A

	Apoptosis and survival BAD phosphorylation
	Regulation of CFTR activity (norm and CF)

3 BioSystems Pathways for PPM1A

	MAPK signaling pathway
	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
	BMP receptor signaling

5/18 Reactome Pathways for PPM1A (see all 18)

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	IRS-related events
	Downregulation of SMAD2/3:SMAD4 transcriptional activity
	IRS-mediated signalling
	Signal Transduction

1 Kegg Pathway (Kegg details for PPM1A):

MAPK signaling pathway

PPM1A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPM1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/149 Interacting proteins for PPM1A (P35813^{1, 2, 3} ENSP00000327255⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 149)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCD	Q05655²^,³, ENSP00000331602⁴	MINT-8387176 I2D: score=2 STRING: ENSP00000331602
ARRB1	P49407¹^,³	EBI-989143,EBI-2561130 I2D: score=1
ARRB2	P32121¹^,³	EBI-989143,EBI-714559 I2D: score=1
AXIN1	O15169²^,³, ENSP00000262320⁴	MINT-8284998 MINT-8277668 MINT-8277635 MINT-8285031 MINT-8277609 MINT-8285013 I2D: score=1 STRING: ENSP00000262320
CDK9	P50750²^,³, ENSP00000362361⁴	MINT-8292829 MINT-8292959 MINT-8292899 I2D: score=1 STRING: ENSP00000362361

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	--
GO:0006351	transcription, DNA-dependent	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0006470	protein dephosphorylation	--	--
GO:0007050	cell cycle arrest	TAS	--

PPM1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPM1A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPM1A

5 HMDB Compounds for PPM1A About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Manganese	manganese	7439-96-5	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 Novoseek chemical compound relationships for PPM1A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	52	1	17073441 (1)
manganese	48.2	1	16879102 (1)
serine	39.1	1	17073441 (1)

Search CenterWatch for drugs/clinical trials and news about PPM1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPM1A gene (3 alternative transcripts):

NM_021003.4 NM_177951.2 NM_177952.2

Unigene Cluster for PPM1A:

Protein phosphatase, Mg2+/Mn2+ dependent, 1A

Hs.130036 [show with all ESTs]

Unigene Representative Sequence: NM_021003

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000325642 ENST00000531143 ENST00000532036 ENST00000395076(uc001xew.4 uc010apn.3 uc001xey.4)

ENST00000325658(uc001xex.4) ENST00000528241 ENST00000525399 ENST00000531937

ENST00000529574

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		8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate PPM1A (see all 139):
		hsa-miR-146a hsa-miR-106a hsa-miR-1245 hsa-miR-3162-5p hsa-miR-761 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-519e

		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): PPM1A 3' UTR sequence

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Additional cDNA sequence:

AB451247.1 AB451371.1 AF070670.1 AK097843.1 AK124299.1 AK308225.1 AK313337.1 AY236965.1

BC026691.1 BC063243.1 S87759.1

12 DOTS entries:

DT.100818830 DT.113018 DT.95268553 DT.100818823 DT.120775109 DT.100718967 DT.100677550 DT.120775110

DT.40113944 DT.92430782 DT.40128061 DT.99953812

24/253 AceView cDNA sequences (see all 253):

BM721910 CD678967 BI491739 AL045078 BM984450 BU167152 AI289045 AI669598

AA827248 BF446834 BM676083 BM782609 BM746381 AA370750 AA370585 BF223859

NM_177952 BM476428 AA886888 CR604498 CA944887 BQ006156 CA391124 AV648740

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPM1A (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12	^	13
SP1:			-		-		-		-		-		-		-		-		-										-
SP2:							-		-		-		-		-		-		-										-
SP3:											-		-		-		-		-
SP4:
SP5:											-

ECgene alternative splicing isoforms for PPM1A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPM1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGGCTGGG

About this image
See PPM1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPM1A

SOURCE GeneReport for Unigene cluster: Hs.130036
SABiosciences Expression via Pathway-Focused PCR Array including PPM1A:

Protein Phosphatases in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPM1A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPM1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1A gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPM1A¹	protein phosphatase, Mg2+/Mn2+ dependent, 1A	88.13(n) 93.98(a)		423525 XM_421422.3 XP_421422.1
lizard (Anolis carolinensis)	Reptilia	PPM1A⁶	--	91(a)	1 ↔ 1	GL343261.1(1089852-1102584)
African clawed frog (Xenopus laevis)	Amphibia	ppm1a-prov²	protein phosphatase 1A (formerly 2C), magnesium-dependent, more	83.74(n)		BC042302.1
zebrafish (Danio rerio)	Actinopterygii	Dr.11472²	Transcribed sequence with moderate similarity to protein more	75.27(n)		57095328
fruit fly (Drosophila melanogaster)	Insecta	CG1906³	protein amino acid dephosphorylation protein serine/threonine more	52(a) (best of 4)		99B4 --
worm (Caenorhabditis elegans)	Secernentea	F25D1.1³	protein phosphatase	48(a) (best of 2)		V(10535971-10538573) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G33700⁶ AT3G51470⁶ (see all 8)	putative protein phosphatase 2C 47 (see all 8)	23(a) 22(a) (see all 8)	possible ortholog possible ortholog (see all 8)	2(14253424-14255993) 3(19097787-19099275)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	protein phosphatase 2C, putative, expressed (see all 10)	25(a) 23(a) (see all 10)	possible ortholog possible ortholog (see all 10)	10(21054681-21058573) 2(34020404-34024433)

ENSEMBL Gene Tree for PPM1A (if available)
TreeFam Gene Tree for PPM1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PPM1A gene

PPM1D² PPM1B² PPM1N² PPM1G²

2 SIMAP similar genes for PPM1A using alignment to 8 protein entries: PPM1A_HUMAN (see all proteins):

PPM1B PPM1N

PPM1A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PPM1A
PGOHUM00000249256

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183893750^1,2		--	60710500(+)	`AGAGAC/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs142423072^1,2		--	60710714(+)	`CTCCAC/TACCAC`	1	--	us2k¹		0	--	--	--	--
rs201307365^1,2		--	60711122(+)	`GACAG-/TTTAAAC`	1	--	us2k¹		0	--	--	--	--
rs189060481^1,2		--	60711157(+)	`GCCCAC/TTCAAA`	1	--	us2k¹		0	--	--	--	--
rs151324029^1,2		--	60711376(+)	`CCCACC/TGCAAC`	1	--	us2k¹		0	--	--	--	--
rs115632685^1,2	F	--	60711460(+)	`CAGGCG/ATGTGC`	1	--	us2k¹		1		WA	118
rs11626992^1,2	C,F,A,H	--	60711499(+)	`agtagC/Agacgg`	1	--	us2k¹		9		NA WA CSA	16
rs116169857^1,2	F	--	60711698(+)	`TACCCG/ATGCAC`	1	--	us2k¹		2		WA NA	238
rs181418613^1,2		--	60711762(+)	`ACTCTC/GGAAAC`	1	--	us2k¹		0	--	--	--	--
rs77133115^1,2	C	--	60711956(+)	`NNNNAG/AAGGTC`	1	--	us2k¹		2		NA	122

HapMap Linkage Disequilibrium report for PPM1A (60712470 - 60765805 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PPM1A
1 CNV: 101962
1 Indel: 45288

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PPM1A for disorders           About GeneDecksing

OMIM gene information: 606108    OMIM disorders: --

5 diseases for PPM1A:    About MalaCards

yaws intrahepatic cholangiocarcinoma cholangiocarcinoma hepatocellular carcinoma

carcinoma

1 Novoseek disease relationship for PPM1A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	16509582 (1)

Human Genome Epidemiology (HuGE) Navigator: PPM1A (2 documents)

Export disorders for PPM1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPM1A gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with PPM1A)

Utopia: connect your pdf to the dynamic
world of online information

Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. (PubMed id 1311954)^{1, 2, 3, 9} Mann D.J.... Cohen P.T.W. (1992)
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. (PubMed id 16751101)^{1, 2} Lin X....Feng X.H. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways. (PubMed id 9707433)^{1, 2} Takekawa M.... Saito H. (1998)
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0-A resolution. (PubMed id 9003755)^{1, 2} Das A.K.... Barford D. (1996)
Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. (PubMed id 12514180)^{1, 9} Ofek P....Lavi S. (2003)
Protein phosphatase 1A (PPM1A) is involved in human c ytotrophoblast cell invasion and migration. (PubMed id 19404668)^{1, 9} Zhang B....Wang H. (2009)
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. (PubMed id 15016818)^{1, 9} Yoshizaki T....Kashiwagi A. (2004)
Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides. (PubMed id 11959144)^{1, 9} Srivastava J....Parker P.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5494	HGNC: 9275	AceView: PPM1A	Ensembl:ENSG00000100614	euGenes: HUgn5494
ECgene: PPM1A	Kegg: 5494	H-InvDB: PPM1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PPM1A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPM1A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PPM1A gene
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Patent Information for PPM1A gene:
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GeneCards and IP:
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protein phosphatase, Mg2+/Mn2+ dependent, 1A

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protein phosphatase, Mg2+/Mn2+ dependent, 1A

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