Aliases for PPL Gene
External Ids for PPL Gene
Previous GeneCards Identifiers for PPL Gene
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPL Gene
PPL (Periplakin) is a Protein Coding gene. Diseases associated with PPL include Paraneoplastic Pemphigus and Pemphigus. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is EVPL.
UniProtKB/Swiss-Prot for PPL Gene
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.