PPIP5K2 Gene
protein-coding GIFtS: 50
GCID: GC05P102455
|
|
diphosphoinositol pentakisphosphate kinase 2(Previous name: histidine acid phosphatase domain containing 1 )
(Previous symbol: HISPPD1)
| |
Aliases
for PPIP5K2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Diphosphoinositol Pentakisphosphate Kinase 21 2 3 | | Histidine Acid Phosphatase Domain Containing 11 | | HISPPD11 2 3 5 | | IP7K22 | | VIP21 2 3 5 | | Inositol Heptaphosphate Kinase 22 | | KIAA04331 3 5 | | Inositol Hexakisphosphate And Diphosphoinositol-Pentakisphosphate Kinase 22 | | Histidine Acid Phosphatase Domain-Containing Protein 12 3 | | EC 2.7.4.213 | | InsP6 And PP-IP5 Kinase 22 3 | | EC 2.7.4.243 | | VIP1 Homolog 22 3 | | HsVIP21 |
Export aliases for PPIP5K2 gene to outside databasesPrevious GC identifer: GC05P097646 |
Summaries
for PPIP5K2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPIP5K2:
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cellsignaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24)activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy etal., 2007 (PubMed 17690096)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: VIP2_HUMAN, O43314Function: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesizethe diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, andbis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 andInsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics,exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively,phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4
|
Genomic Views
for PPIP5K2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PPIP5K2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPIP5K2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIP5K2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q21.1 Ensembl cytogenetic band: 5q21.1 HGNC cytogenetic band: 5q21.1PPIP5K2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P102455: view genomic region
(about GC identifiers)
Start:
|
102,455,853 bp from pter |
End:
|
102,538,937 bp from pter |
Size:
|
83,085 bases |
Orientation:
|
plus strand |
|
Proteins
for PPIP5K2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VIP2_HUMAN, O43314 (See
protein sequence)Recommended Name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Size: 1243 amino acids; 140407 Da
Subcellular location: Cytoplasm, cytosol
Sequence caution: Sequence=BAA24863.2; Type=Erroneous initiation; Sequence=EAW49076.1; Type=Erroneous gene modelprediction;
6/10 PDB 3D structures from  and Proteopedia  for PPIP5K2 (see all 10):3T54 (3D)
3T7A (3D)
3T99 (3D)
3T9A (3D)
3T9B (3D)
3T9C (3D)
Secondary accessions: A1NI53 A6NGS8 Q8TB50Alternative splicing: 2 isoforms: O43314-1 O43314-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PPIP5K2: NX_O43314
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43314
PPIP5K2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001263206.1 NP_056031.2
ENSEMBL proteins: ENSP00000421513 ENSP00000313070 ENSP00000422525 ENSP00000465165 ENSP00000351126 ENSP00000467529 ENSP00000424535 ENSP00000424948 ENSP00000467099 ENSP00000416016 Reactome Protein details: O43314
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
ISS | -- |
PPIP5K2 for ontologies About GeneDecksing
PPIP5K2 Antibody Products:
Assay Products for PPIP5K2: |
Protein
Domains /
Families
for PPIP5K2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPIP5K2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O43314ProtoNet protein and cluster: O43314 1 Blocks protein family: IPB000560 Histidine acid phosphatase
UniProtKB/Swiss-Prot: VIP2_HUMAN, O43314Domain: The polyphosphoinositide-binding domain mediates binding of PtdIns(3,4,5)P3 and InsP6. Despite its similaritywith the phosphatase domain of histidine acid phosphatases, it has no phosphatase activitySimilarity: Belongs to the histidine acid phosphatase family. VIP1 subfamily |
Function
for PPIP5K2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VIP2_HUMAN, O43314Function: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesizethe diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, andbis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 andInsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics,exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively,phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4Catalytic activity: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate1,2,3,4,6-pentakisphosphateCatalytic activity: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphatetetrakisphosphate (isomeric configuration unknown)Catalytic activity: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphatetetrakisphosphate (isomeric configuration unknown)Biophysicochemical properties: Kinetic parameters: KM=0.13 uM for InsP6; KM=0.19 uM for InsP7; Vmax=0.39 nmol/min/mgenzyme with InsP6 as substrate; Vmax=1.38 nmol/min/mg enzyme with InsP7 as substrate;Enzyme Numbers (IUBMB): EC 2.7.4.241 EC 2.7.4.211
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIP5K2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIP5K2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIP5K2 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000827 | inositol-1,3,4,5,6-pentakisphosphate kinase activity |
ISS | -- | | GO:0000832 | inositol hexakisphosphate 5-kinase activity |
ISS | -- | | GO:0003993 | acid phosphatase activity |
-- | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016301 | kinase activity |
IEA | -- |
PPIP5K2 for ontologies About GeneDecksing
|
Pathways & Interactions
for PPIP5K2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | inositol pyrophosphates biosynthesis | | | 2 | Metabolism | | | 3 | Inositol phosphate metabolism | | | 4 | Synthesis of IP3 and IP4 in the cytosol | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for PPIP5K2
3 
Reactome Pathways for PPIP5K2
PPIP5K2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIP5K2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/18 Interacting proteins for PPIP5K2 (O433143 ENSP000003130704) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006020 | inositol metabolic process |
ISS | -- |
PPIP5K2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PPIP5K2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PPIP5K2
Search CenterWatch for drugs/clinical trials and news about PPIP5K2 / VIP2
|
Transcripts
for PPIP5K2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPIP5K2 gene (2 alternative transcripts): NM_001276277.1 NM_015216.3 Unigene Cluster for PPIP5K2: Diphosphoinositol pentakisphosphate kinase 2 Hs.212046 [show with all ESTs]Unigene Representative Sequence: AB00789316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515845 ENST00000321521(uc010jbo.2 uc003koe.3 uc003kof.3)
ENST00000507921 ENST00000504275 ENST00000358359(uc011cva.2 uc003kod.4)
ENST00000513500 ENST00000502481 ENST00000507310 ENST00000509597 ENST00000508935
ENST00000511724 ENST00000507966 ENST00000511022 ENST00000510672 ENST00000504083
ENST00000414217
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIP5K2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIP5K2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPIP5K2 (NM_015216) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIP5K2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIP5K2 |
Additional cDNA sequence: AB007893.1 AK025159.1 AK027116.1 AK294787.1 BC024591.1 JQ313907.1 13 DOTS entries: DT.97845967 DT.315142 DT.97845969 DT.75154908 DT.99964844 DT.100659469 DT.75106156 DT.92433068 DT.95071358 DT.120859894 DT.92433066 DT.92433067 DT.95287244 24/173 AceView cDNA sequences (see all 173): AW117893 AL597824 NM_015216 AI653820 BM467990 CR597259 BU633495 AA704448 AW966593 BM801176 AW027424 BI522622 BE674849 AI358379 BQ022621 BE157258 BM479072 BM468670 CA436909 BM802944 AL134362 AL521758 CA425941 BC024591
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PPIP5K2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PPIP5K2
|
Expression
for PPIP5K2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPIP5K2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTGTAAAC
About this image
See PPIP5K2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIP5K2
SOURCE GeneReport for Unigene cluster: Hs.212046
SABiosciences Custom PCR Arrays for PPIP5K2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIP5K2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPIP5K2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIP5K2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIP5K2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIP5K2 |
Orthologs
for PPIP5K2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPIP5K2 gene from 9/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ppip5k21 , 5 |
diphosphoinositol pentakisphosphate kinase 21, 5 |
88.63(n)1
94.84(a)1 |
|
1 (47.76 cM)5
2273991 NM_173760.41 NP_776121.31
977060485 |
chicken
(Gallus gallus) |
Aves |
PPIP5K21 |
diphosphoinositol pentakisphosphate kinase 2 |
82.84(n)
89.17(a) |
|
427276 XM_424859.3 XP_424859.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PPIP5K26 |
-- |
86(a) |
1 ↔ 1 |
GL343193.1(1718033-1777271) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.189712 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.03(n) |
|
CA791032.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
im:71377781 |
im:7137778 |
74.98(n)
87.67(a) |
|
449862 XM_002663490.1 XP_002663536.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(1)G01966 |
lethal (1) G0196 |
37(a) |
possible ortholog |
X(21889016-21909502) |
worm
(Caenorhabditis elegans) |
Secernentea |
F46F11.16 |
Inositol hexakisphosphate and diphosphoinositol-pe... |
42(a) |
possible ortholog |
I(5627820-5637620) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G013101 |
phosphoglycerate mutase-like-like protein |
56.31(n)
52.62(a) |
|
821297 NM_001035537.2 NP_001030614.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.191642 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.28(n) |
|
AK064988.1 |
ENSEMBL Gene Tree for PPIP5K2 (if available)
TreeFam Gene Tree for PPIP5K2 (if available) |
Paralogs
for PPIP5K2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPIP5K2 gene
- PPIP5K12
8 SIMAP similar genes for PPIP5K2 using alignment to 8 protein entries: VIP2_HUMAN (see all proteins):MTA3 ZNF568 NSD1 PPIP5K1 HKR1 NSRP1
ATL2 C11orf80
PPIP5K2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PPIP5K2
PGOHUM00000244071
|
Genomic Variants
for PPIP5K2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPIP5K2 (102455853 - 102538937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPIP5K2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIP5K2 |
|
Disorders
/ Diseases
for PPIP5K2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPIP5K2 for disorders About GeneDecksing
OMIM gene information: 611648
OMIM disorders: --
3  diseases for PPIP5K2: About MalaCardsmhc class ii deficiency priapism malaria
Human Genome Epidemiology (HuGE) Navigator: PPIP5K2 (2 documents)
Export disorders for PPIP5K2 gene to outside databases
|
Publications
for PPIP5K2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPIP5K2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with PPIP5K2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. (PubMed id 17690096)1, 2, 3 Fridy P.C.... York J.D. (2007)
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
- Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. (PubMed id 22119861)1, 2 Wang H....Shears S.B. (2012)
- Structural analysis and detection of biological inosi tol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphos phate kinases are 1/3-kinases. (PubMed id 18981179)1, 3 Lin H....Mayr G.W. (2009)
- Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. (PubMed id 17702752)1, 2 Choi J.H.... Shears S.B. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. (PubMed id 21222653)2 Gokhale N.A....Shears S.B. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
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External Searches for PPIP5K2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PPIP5K2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PPIP5K2 gene
(According to HUGE)
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Specialized Databases showing PPIP5K2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PPIP5K2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for PPIP5K2 gene:
Search GeneIP for patents involving PPIP5K2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PPIP5K2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PPIP5K2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIP5K2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIP5K2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPIP5K2 | | OriGene 3'-UTR Clone for PPIP5K2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIP5K2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIP5K2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIP5K2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIP5K2 |
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