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Aliases for PPIP5K2 Gene

Aliases for PPIP5K2 Gene

  • Diphosphoinositol Pentakisphosphate Kinase 2 2 3 4 5
  • Histidine Acid Phosphatase Domain-Containing Protein 1 3 4
  • InsP6 And PP-IP5 Kinase 2 3 4
  • VIP1 Homolog 2 3 4
  • HISPPD1 3 4
  • VIP2 3 4
  • Histidine Acid Phosphatase Domain Containing 1 2
  • Inositol Heptaphosphate Kinase 2 3
  • EC 2.7.4.21 4
  • EC 2.7.4.24 4
  • KIAA0433 4
  • CFAP160 3
  • HsVIP2 4
  • IP7K2 3

External Ids for PPIP5K2 Gene

Previous HGNC Symbols for PPIP5K2 Gene

  • HISPPD1

Previous GeneCards Identifiers for PPIP5K2 Gene

  • GC05P102455
  • GC05P097646

Summaries for PPIP5K2 Gene

Entrez Gene Summary for PPIP5K2 Gene

  • Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PPIP5K2 Gene

PPIP5K2 (Diphosphoinositol Pentakisphosphate Kinase 2) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include acid phosphatase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is PPIP5K1.

UniProtKB/Swiss-Prot for PPIP5K2 Gene

  • Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIP5K2 Gene

Genomics for PPIP5K2 Gene

Regulatory Elements for PPIP5K2 Gene

Enhancers for PPIP5K2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIP5K2 on UCSC Golden Path with GeneCards custom track

Promoters for PPIP5K2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIP5K2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIP5K2 Gene

Chromosome:
5
Start:
103,120,149 bp from pter
End:
103,212,799 bp from pter
Size:
92,651 bases
Orientation:
Plus strand

Genomic View for PPIP5K2 Gene

Genes around PPIP5K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIP5K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIP5K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIP5K2 Gene

Proteins for PPIP5K2 Gene

  • Protein details for PPIP5K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43314-VIP2_HUMAN
    Recommended name:
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
    Protein Accession:
    O43314
    Secondary Accessions:
    • A1NI53
    • A6NGS8
    • Q8TB50

    Protein attributes for PPIP5K2 Gene

    Size:
    1243 amino acids
    Molecular mass:
    140407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24863.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW49076.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPIP5K2 Gene

    Alternative splice isoforms for PPIP5K2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIP5K2 Gene

Proteomics data for PPIP5K2 Gene at MOPED

Post-translational modifications for PPIP5K2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PPIP5K2 Gene

Domains & Families for PPIP5K2 Gene

Protein Domains for PPIP5K2 Gene

Suggested Antigen Peptide Sequences for PPIP5K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43314

UniProtKB/Swiss-Prot:

VIP2_HUMAN :
  • The polyphosphoinositide-binding domain mediates binding of PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.
  • Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Domain:
  • The polyphosphoinositide-binding domain mediates binding of PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.
Family:
  • Belongs to the histidine acid phosphatase family. VIP1 subfamily.
genes like me logo Genes that share domains with PPIP5K2: view

No data available for Gene Families for PPIP5K2 Gene

Function for PPIP5K2 Gene

Molecular function for PPIP5K2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.13 uM for InsP6 {ECO:0000269 PubMed:17690096}; KM=0.19 uM for InsP7 {ECO:0000269 PubMed:17690096}; Vmax=0.39 nmol/min/mg enzyme with InsP6 as substrate {ECO:0000269 PubMed:17690096}; Vmax=1.38 nmol/min/mg enzyme with InsP7 as substrate {ECO:0000269 PubMed:17690096};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.
UniProtKB/Swiss-Prot Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.

Enzyme Numbers (IUBMB) for PPIP5K2 Gene

Gene Ontology (GO) - Molecular Function for PPIP5K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000828 inositol hexakisphosphate kinase activity IEA,TAS --
GO:0000829 inositol heptakisphosphate kinase activity TAS --
GO:0033857 diphosphoinositol-pentakisphosphate kinase activity IEA,ISS --
GO:0052723 inositol hexakisphosphate 1-kinase activity IEA --
GO:0052724 inositol hexakisphosphate 3-kinase activity IEA --
genes like me logo Genes that share ontologies with PPIP5K2: view
genes like me logo Genes that share phenotypes with PPIP5K2: view

Animal Model Products

CRISPR Products

miRNA for PPIP5K2 Gene

miRTarBase miRNAs that target PPIP5K2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIP5K2 Gene

Localization for PPIP5K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIP5K2 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIP5K2 Gene COMPARTMENTS Subcellular localization image for PPIP5K2 gene
Compartment Confidence
cytosol 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for PPIP5K2 Gene

Pathways & Interactions for PPIP5K2 Gene

genes like me logo Genes that share pathways with PPIP5K2: view

Pathways by source for PPIP5K2 Gene

Interacting Proteins for PPIP5K2 Gene

Gene Ontology (GO) - Biological Process for PPIP5K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PPIP5K2: view

No data available for SIGNOR curated interactions for PPIP5K2 Gene

Drugs & Compounds for PPIP5K2 Gene

(1) Drugs for PPIP5K2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for PPIP5K2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Diphosphoinositol pentakisphosphate
  • 1,2,3,4,6-Pentakis-O-phosphono-1D-myo-inositol 5-(trihydrogen diphosphate)
  • 1D-Myo-inositol 5-diphosphate pentakisphosphate
  • 5-Diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
  • 5-Diphospho-1D-myo-inositol pentakisphosphate
  • 5-PP-InsP5
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PPIP5K2: view

Transcripts for PPIP5K2 Gene

Unigene Clusters for PPIP5K2 Gene

Diphosphoinositol pentakisphosphate kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIP5K2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PPIP5K2 Gene

GeneLoc Exon Structure for
PPIP5K2
ECgene alternative splicing isoforms for
PPIP5K2

Expression for PPIP5K2 Gene

mRNA expression in normal human tissues for PPIP5K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIP5K2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9) and Lymph node (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIP5K2 Gene



SOURCE GeneReport for Unigene cluster for PPIP5K2 Gene Hs.212046

genes like me logo Genes that share expression patterns with PPIP5K2: view

Protein tissue co-expression partners for PPIP5K2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIP5K2 Gene

Orthologs for PPIP5K2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIP5K2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIP5K2 35
  • 94.35 (n)
  • 97.3 (a)
PPIP5K2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIP5K2 35
  • 95.2 (n)
  • 97.99 (a)
PPIP5K2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppip5k2 35
  • 88.61 (n)
  • 94.84 (a)
Ppip5k2 16
Ppip5k2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIP5K2 35
  • 99.9 (n)
  • 99.92 (a)
PPIP5K2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIP5K2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIP5K2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIP5K2 35
  • 83.14 (n)
  • 89.44 (a)
PPIP5K2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIP5K2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18971 35
zebrafish
(Danio rerio)
Actinopterygii ppip5k2 35
  • 74.73 (n)
  • 86.63 (a)
ppip5k2 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000926 35
  • 60.22 (n)
  • 72.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0196 35
  • 64.03 (n)
  • 72.39 (a)
l(1)G0196 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F46F11.1 35
  • 57.86 (n)
  • 53.4 (a)
F46F11.1 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VIP1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G01310 35
  • 57.31 (n)
  • 53 (a)
rice
(Oryza sativa)
Liliopsida Os.19164 35
Os03g0689100 35
  • 56.45 (n)
  • 52.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.643 36
  • 64 (a)
OneToMany
Species with no ortholog for PPIP5K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIP5K2 Gene

ENSEMBL:
Gene Tree for PPIP5K2 (if available)
TreeFam:
Gene Tree for PPIP5K2 (if available)

Paralogs for PPIP5K2 Gene

Paralogs for PPIP5K2 Gene

(7) SIMAP similar genes for PPIP5K2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PPIP5K2 Gene

genes like me logo Genes that share paralogs with PPIP5K2: view

Variants for PPIP5K2 Gene

Sequence variations from dbSNP and Humsavar for PPIP5K2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17155115 - 103,180,097(+) TCGAG(C/G)TGTGA reference, missense
rs12519525 - 103,183,264(-) GCCCA(A/C/G/T)AGGGT intron-variant, downstream-variant-500B, reference, missense, stop-gained
rs12520040 - 103,183,319(+) TCGAA(A/G)ACGCA intron-variant, downstream-variant-500B, reference, missense
rs17155138 - 103,195,023(+) CAAAC(A/C)AGGTA reference, missense
rs17155147 - 103,201,597(+) AGAAA(C/T)GCATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PPIP5K2 Gene

Variant ID Type Subtype PubMed ID
nsv882519 CNV Loss 21882294
nsv830430 CNV Gain 17160897
nsv882520 CNV Loss 21882294
nsv882521 CNV Loss 21882294

Variation tolerance for PPIP5K2 Gene

Residual Variation Intolerance Score: 2.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIP5K2 Gene

HapMap Linkage Disequilibrium report
PPIP5K2
Human Gene Mutation Database (HGMD)
PPIP5K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIP5K2 Gene

Disorders for PPIP5K2 Gene

Relevant External Links for PPIP5K2

Human Genome Epidemiology (HuGE) Navigator
PPIP5K2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIP5K2

No disorders were found for PPIP5K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIP5K2 Gene

Publications for PPIP5K2 Gene

  1. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. (PMID: 17690096) Fridy P.C. … York J.D. (J. Biol. Chem. 2007) 2 3 4 67
  2. Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. (PMID: 18981179) Lin H. … Mayr G.W. (J. Biol. Chem. 2009) 2 3
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Identification of a functional nuclear translocation sequence in hPPIP5K2. (PMID: 26084399) Yong S.T. … Shears S.B. (BMC Cell Biol. 2015) 3

Products for PPIP5K2 Gene

Sources for PPIP5K2 Gene

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