Aliases for PPIP5K2 Gene
External Ids for PPIP5K2 Gene
Previous HGNC Symbols for PPIP5K2 Gene
Previous GeneCards Identifiers for PPIP5K2 Gene
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 22.214.171.124) and PP-IP5 (also called IP7) kinase (EC 126.96.36.199) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PPIP5K2 Gene
PPIP5K2 (Diphosphoinositol Pentakisphosphate Kinase 2) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Metabolism. GO annotations related to this gene include acid phosphatase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is PPIP5K1.
UniProtKB/Swiss-Prot for PPIP5K2 Gene
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.