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Aliases for PPIL6 Gene

Aliases for PPIL6 Gene

  • Peptidylprolyl Isomerase Like 6 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 6 2 3
  • Cyclophilin-Like Protein PPIL6 3 4
  • Rotamase PPIL6 3 4
  • EC 4 58
  • PPIASE 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like Variant A 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 6 3
  • Radial Spoke 12 Homolog (Chlamydomonas) 2
  • Radial Spoke 12 Homolog 3
  • BA425D10.6 3
  • DJ919F19.1 3
  • RSPH12 3

External Ids for PPIL6 Gene

Previous GeneCards Identifiers for PPIL6 Gene

  • GC06M109714
  • GC06M109759
  • GC06M109820
  • GC06M109711
  • GC06M107277

Summaries for PPIL6 Gene

GeneCards Summary for PPIL6 Gene

PPIL6 (Peptidylprolyl Isomerase Like 6) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIG.

UniProtKB/Swiss-Prot for PPIL6 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Additional gene information for PPIL6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL6 Gene

Genomics for PPIL6 Gene

Regulatory Elements for PPIL6 Gene

Enhancers for PPIL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H109379 1.4 ENCODE dbSUPER 11.8 +58.8 58818 6.3 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 SSRP1 ZNF610 GLIS1 NBN ZBTB24 SMPD2 ENSG00000260273 MICAL1 AK9 PPIL6 PTCHD3P3 ENSG00000233908 CCDC162P LOC105377935
GH06H109316 1.4 Ensembl ENCODE dbSUPER 10.5 +122.6 122589 4 FOXA2 ARID4B RAD21 YY1 MIXL1 SP5 REST NR2F2 KAT8 NFIL3 CD164 CCDC162P PTCHD3P3 ENSG00000233908 PPIL6 SMPD2 RPL7P28 RNY3P11
GH06H109373 1.1 ENCODE dbSUPER 10.9 +67.2 67172 1.7 HDGF TBL1XR1 BACH1 BMI1 BATF RFX5 RELA GATA3 POLR2A EED SMPD2 ENSG00000260273 PPIL6 PTCHD3P3 ENSG00000233908 CCDC162P ZBTB24 CD164 LOC101927538
GH06H109313 1.1 FANTOM5 ENCODE dbSUPER 10.5 +126.3 126258 2.7 PKNOX1 SCRT2 FOXP1 CCDC162P PTCHD3P3 ENSG00000233908 CD164 SMPD2 PPIL6 RNY3P11 RPL7P28
GH06H109228 0.7 ENCODE 15.5 +211.0 211040 2.8 SMARCE1 PKNOX1 KLF1 ZNF687 MNT ELF1 KLF4 DPF2 FOXA1 ZNF217 CCDC162P CD164 PPIL6 ENSG00000233908 PTCHD3P3 SMPD2 ZBTB24 C6orf183 LOC105377933
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPIL6 on UCSC Golden Path with GeneCards custom track

Promoters for PPIL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000200967 770 2000 ARNT SIN3A DMAP1 YY1 ZNF766 ZNF143 SP3 SP5 REST ZNF592

Genomic Locations for PPIL6 Gene

Genomic Locations for PPIL6 Gene
50,957 bases
Minus strand

Genomic View for PPIL6 Gene

Genes around PPIL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL6 Gene

Proteins for PPIL6 Gene

  • Protein details for PPIL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 6
    Protein Accession:
    Secondary Accessions:
    • A9NIU0
    • A9NIU9
    • E7EX15

    Protein attributes for PPIL6 Gene

    311 amino acids
    Molecular mass:
    35228 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPIL6 Gene


neXtProt entry for PPIL6 Gene

Selected DME Specific Peptides for PPIL6 Gene


Post-translational modifications for PPIL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PPIL6 Gene

Gene Families for PPIL6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PPIL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family.
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIL6: view

Function for PPIL6 Gene

Molecular function for PPIL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIL6 Gene

Phenotypes From GWAS Catalog for PPIL6 Gene

Gene Ontology (GO) - Molecular Function for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL6: view
genes like me logo Genes that share phenotypes with PPIL6: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL6 Gene

Localization for PPIL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIL6 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPIL6 Gene

Pathways & Interactions for PPIL6 Gene

SuperPathways for PPIL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIL6: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL6 Gene

Drugs & Compounds for PPIL6 Gene

No Compound Related Data Available

Transcripts for PPIL6 Gene

Unigene Clusters for PPIL6 Gene

Peptidylprolyl isomerase (cyclophilin)-like 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP2: -
SP3: - - -

Relevant External Links for PPIL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPIL6 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for PPIL6 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIL6 Gene

Protein tissue co-expression partners for PPIL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL6 Gene:


SOURCE GeneReport for Unigene cluster for PPIL6 Gene:

genes like me logo Genes that share expression patterns with PPIL6: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIL6 Gene

Orthologs for PPIL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPIL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIL6 33 34
  • 99.7 (n)
(Bos Taurus)
Mammalia PPIL6 33 34
  • 85.99 (n)
(Canis familiaris)
Mammalia PPIL6 33 34
  • 84.92 (n)
(Mus musculus)
Mammalia Ppil6 33 16 34
  • 79.14 (n)
(Rattus norvegicus)
Mammalia Ppil6 33
  • 78.46 (n)
(Monodelphis domestica)
Mammalia PPIL6 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia PPIL6 34
  • 55 (a)
(Gallus gallus)
Aves PPIL6 33 34
  • 66.2 (n)
(Anolis carolinensis)
Reptilia PPIL6 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil6 33
  • 66.43 (n)
(Danio rerio)
Actinopterygii ppil6 33 34
  • 61.27 (n)
(Caenorhabditis elegans)
Secernentea cyn-9 34
  • 24 (a)
cyn-8 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for PPIL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL6 Gene

Gene Tree for PPIL6 (if available)
Gene Tree for PPIL6 (if available)

Paralogs for PPIL6 Gene

Variants for PPIL6 Gene

Sequence variations from dbSNP and Humsavar for PPIL6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000056939 -- 109,437,362(+) CAGGG(G/T)TGAGT intron-variant
rs1000218907 -- 109,398,829(+) TAGTA(A/G)TAAAG intron-variant
rs1000232437 -- 109,419,387(+) ACCAG(C/T)CTGGG intron-variant
rs1000299142 -- 109,435,703(+) GTGGA(A/T)CACTT intron-variant
rs1000315803 -- 109,433,070(+) TTTTT(C/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL6 Gene

Variant ID Type Subtype PubMed ID
nsv823818 CNV gain 20364138
esv3576210 CNV gain 25503493
esv33427 CNV loss 17666407

Variation tolerance for PPIL6 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL6 Gene

Disorders for PPIL6 Gene

Relevant External Links for PPIL6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPIL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL6 Gene

Publications for PPIL6 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for PPIL6 Gene

Sources for PPIL6 Gene

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