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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIL6 Gene

protein-coding   GIFtS: 44
GCID: GC06M109711

peptidylprolyl isomerase (cyclophilin)-like 6

 Explore 3 diseases affiliated with
PPIL6 via our new
 Human Malady Compendium 
Biological research products
for PPIL6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase (Cyclophilin)-Like 61 2     PPIase2 3
RSPH121 2     EC 5.2.1.83 8
BA425D10.61     MGC419391
DJ919F19.11     Peptidyl-Prolyl Cis-Trans Isomerase-Like 62
Cyclophilin-Like Protein PPIL62 3     Peptidyl-Prolyl Cis-Trans Isomerase-Like Variant A2
Rotamase PPIL62 3     Radial Spoke 12 Homolog2

External Ids:    HGNC: 215571   Entrez Gene: 2857552   Ensembl: ENSG000001852507   UniProtKB: Q8IXY83   

Export aliases for PPIL6 gene to outside databases

Previous GC identifers: GC06M109714 GC06M109759 GC06M109820 GC06M107277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PPIL6_HUMAN, Q8IXY8
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIL6 gene promoter:
         CBF-A   MyoD   NF-kappaB   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

PPIL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIL6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109711:  view genomic region     (about GC identifiers)

Start:
109,711,418 bp from pter      End:
109,762,374 bp from pter
Size:
50,957 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPIL6_HUMAN, Q8IXY8 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase-like 6  
Size: 311 amino acids; 35228 Da
Secondary accessions: A9NIU0 A9NIU9
Alternative splicing: 2 isoforms:  Q8IXY8-1   Q8IXY8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPIL6: NX_Q8IXY8

2 DME Specific Peptides for PPIL6 (Q8IXY8)
 FGQLIEG  SIYGPTFEDE 

PPIL6 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_001104768.2  NP_775943.1  

ENSEMBL proteins: 
 ENSP00000389292   ENSP00000392257   ENSP00000427929   ENSP00000427899   ENSP00000411731  
 ENSP00000430998   ENSP00000407731  

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Uscn Proteins for PPIL6


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Uscn ELISAs and CLIAs for PPIL6


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPIL6 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002130 Cyclophilin-like_PPIase_dom

Graphical View of Domain Structure for InterPro Entry Q8IXY8

ProtoNet protein and cluster: Q8IXY8

1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: PPIL6_HUMAN, Q8IXY8
Similarity: Belongs to the cyclophilin-type PPIase family
Similarity: Contains 1 PPIase cyclophilin-type domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: PPIL6_HUMAN, Q8IXY8
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme Number (IUBMB): EC 5.2.1.81 2

miRNA
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hsa-miR-607 hsa-miR-125a-3p hsa-miR-520d-5p hsa-miR-1285 hsa-miR-346 hsa-miR-766 hsa-miR-29b-1* hsa-miR-1262
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Inhib. RNA
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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--


PPIL6 for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIL6

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006457protein folding IEA--


PPIL6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPIL6
Search CenterWatch for drugs/clinical trials and news about PPIL6 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPIL6 gene (2 alternative transcripts): 
NM_001111298.2  NM_173672.4  

Unigene Cluster for PPIL6:

Peptidylprolyl isomerase (cyclophilin)-like 6
Hs.32234  [show with all ESTs]
Unigene Representative Sequence: NM_001111298
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000447468 ENST00000440797 ENST00000521072 ENST00000520723 ENST00000417394
ENST00000518648 ENST00000524031 ENST00000424445(uc010kdp.3 uc003ptg.4 uc021zdq.1)


miRNA
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8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIL6 (see all 25):
hsa-miR-607 hsa-miR-125a-3p hsa-miR-520d-5p hsa-miR-1285 hsa-miR-346 hsa-miR-766 hsa-miR-29b-1* hsa-miR-1262
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIL6 (see all 4)
OriGene shRNA RFP: PPIL6
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIL6
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL6 (see all 3)
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GenScript: all cDNA clones in your preferred vector (see all 2): PPIL6 (NM_173672)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL6 
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIL6

Additional cDNA sequence: 

AK293674.1 AK315790.1 BC026359.1 BC026360.1 BC038716.1 DQ363562.1 DQ423529.1 

7 DOTS entries:

DT.99997807  DT.311601  DT.92416687  DT.95346694  DT.40132320  DT.92416686  DT.99961319 

24/40 AceView cDNA sequences (see all 40):

BM673867 AI125375 CB164135 AI052546 AA873487 CB243341 AW470051 BG399112 
AI369898 BM931128 BC038716 AI301752 BF110715 AA620637 R83355 AA620658 
R83790 BM750422 AW468706 AI684001 AI215716 BI824055 BG215138 NM_173672 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIL6    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1:                                                                  
SP2:              -                                                   
SP3:              -           -     -                                 


ECgene alternative splicing isoforms for PPIL6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPIL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

PPIL6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
AdiposeVisceral White AdiposeAdipose
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Posterior foregut-like cells (A scalable, suspensi...)

See PPIL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIL6

SOURCE GeneReport for Unigene cluster: Hs.32234
    SABiosciences Custom PCR Arrays for PPIL6
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIL6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for PPIL6 gene from 8/28 species (see all 28)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves PPIL61 peptidylprolyl isomerase (cyclophilin)-like 6 66.31(n)
63.03(a)
  421764  XM_419794.2  XP_419794.2 
lizard
(Anolis carolinensis)
Reptilia PPIL66
--
55(a)
1 ↔ 1
1(191136565-191149865)
zebrafish
(Danio rerio)
Actinopterygii ppil61 peptidylprolyl isomerase (cyclophilin)-like 6 61.27(n)
58.1(a)
  553623  NM_001020597.1  NP_001018433.1 
honey bee
(Apis mellifera)
Insecta --
--
14(a)
1 ↔ 1
GroupUn.1104(1908-4397)
worm
(Caenorhabditis elegans)
Secernentea T22F3.126
cyn-156
CYclophyliN family member (cyn-15)
40(a)
10(a)
1 ↔ 1
possible ortholog
V(3589016-3592186)
I(13566086-13572052)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G269406
Cyclophilin-like peptidyl-prolyl cis-trans isomera...
16(a)
possible ortholog
1(9343126-9345145)
rice
(Oryza sativa)
Liliopsida --
peptidyl-prolyl cis-trans isomerase, putative, exp...
15(a)
possible ortholog
11(22746338-22751340)
E. coli
(Escherichia coli)
Gamma proteobacteria ppiB6
ppiA6
peptidyl-prolyl cis-trans isomerase B (rotamase B)...
peptidyl-prolyl cis-trans isomerase A (rotamase A)...
23(a)
22(a)
possible ortholog
possible ortholog
Chromosome(553166-553660)
Chromosome(3489747-3490319)


ENSEMBL Gene Tree for PPIL6 (if available)
TreeFam Gene Tree for PPIL6 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PPIL6 gene
NKTR2  PPID2  PPIG2  
18/31 SIMAP similar genes for PPIL6 using alignment to 7 protein entries:     PPIL6_HUMAN (see all proteins) (see all similar genes):
KIAA1651    KIAA0101    C12orf76    COQ5    FLJ16124    TUBA1C
GALK2    SH2B3    GBGT1    PFKFB3    SNRPF    GEMIN6
PPIG    NCKAP1L    PPID    DKFZp686G0426    RANBP2    NKTR

PPIL6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/759 NCBI SNPs in PPIL6 are shown (see all 759    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1473920601,2
--109710953(+) TGGCA-/GAGTTC 2 -- int10--------
rs1453646861,2
--109711120(+) GTAACA/GCTTGT 2 -- int10--------
rs784797321,2
C,F,--109711206(+) AGCTCC/GCTTTT 2 -- int12Minor allele frequency- G:0.05NA EA 240
rs1492059881,2
--109711228(+) CCCCAC/GTGTGA 2 -- int10--------
rs1844091031,2
--109711316(+) GAAGTC/TTGTGA 2 -- int10--------
rs69399531,2
C,F,A,H,--109711319(+) GTCTGC/TGAGTA 2 -- int115Minor allele frequency- N:0.02EA NA WA CSA 569
rs126653491,2
C,F,H,--109711449(+) ATTAAA/CTTTAT 2 -- ut311Minor allele frequency- C:0.06EA 120
rs585359121,2
C,--109711476(+) ACCAGT/GTCTCT 2 -- ut314Minor allele frequency- G:0.45WA CSA 123
rs761653871,2
C,F,--109711603(+) TGTGCA/CGCTAG 2 -- ut312Minor allele frequency- C:0.04WA EA 238
rs1866642251,2
--109711619(+) GGCAGA/GGCCAG 2 -- ut310--------

HapMap Linkage Disequilibrium report for PPIL6 (109711418 - 109762374 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PPIL6
     1 Indel: 11262

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPIL6 for disorders           About GeneDecksing

3 diseases for PPIL6:    About MalaCards
tuberculosis    malaria    mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: PPIL6 (1 document)

Export disorders for PPIL6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PPIL6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PPIL6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  3. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1 Gudbjartsson D.F....Stefansson K. (2008)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 285755 HGNC: 21557 AceView: PPIL6 Ensembl:ENSG00000185250 euGenes: HUgn285755
ECgene: PPIL6 H-InvDB: PPIL6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for PPIL6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for PPIL6 gene:
Search GeneIP for patents involving PPIL6

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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 OriGene Antibodies for PPIL6   OriGene shRNA RFP for PPIL6  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIL6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIL6  
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPIL6
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 GenScript Custom Purified and Recombinant Proteins Services for PPIL6 GenScript cDNA clones with any tag delivered in your preferred vector for PPIL6
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 Regulatory tfbs in PPIL6 promoter
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 PPIL6 Proteins, Antibodies, CLIAs, and ELISAs
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL6
 Browse SwitchGear 3'UTR luciferase reporter plasmids for PPIL6
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL6
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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