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Aliases for PPIL6 Gene

Aliases for PPIL6 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 6 2 3
  • Cyclophilin-Like Protein PPIL6 3 4
  • Rotamase PPIL6 3 4
  • EC 5.2.1.8 4 63
  • PPIASE 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like Variant A 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 6 3
  • Radial Spoke 12 Homolog (Chlamydomonas) 2
  • Radial Spoke 12 Homolog 3
  • BA425D10.6 3
  • DJ919F19.1 3
  • RSPH12 3

External Ids for PPIL6 Gene

Summaries for PPIL6 Gene

GeneCards Summary for PPIL6 Gene

PPIL6 (Peptidylprolyl Isomerase (Cyclophilin)-Like 6) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPID.

UniProtKB/Swiss-Prot for PPIL6 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL6 Gene

Genomics for PPIL6 Gene

Genomic Location for PPIL6 Gene

Start:
109,390,215 bp from pter
End:
109,441,171 bp from pter
Size:
50,957 bases
Orientation:
Minus strand

Genomic View for PPIL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL6 Gene

Regulatory Elements for PPIL6 Gene

Proteins for PPIL6 Gene

  • Protein details for PPIL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXY8-PPIL6_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 6
    Protein Accession:
    Q8IXY8
    Secondary Accessions:
    • A9NIU0
    • A9NIU9
    • E7EX15

    Protein attributes for PPIL6 Gene

    Size:
    311 amino acids
    Molecular mass:
    35228 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPIL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL6 Gene

Proteomics data for PPIL6 Gene at MOPED

Selected DME Specific Peptides for PPIL6 Gene

Post-translational modifications for PPIL6 Gene

No Post-translational modifications

Domains for PPIL6 Gene

Suggested Antigen Peptide Sequences for PPIL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXY8

UniProtKB/Swiss-Prot:

PPIL6_HUMAN
Domain:
  • Contains 1 PPIase cyclophilin-type domain.:
    • Q8IXY8
Family:
  • Belongs to the cyclophilin-type PPIase family.:
    • Q8IXY8
genes like me logo Genes that share domains with PPIL6: view

No data available for Gene Families for PPIL6 Gene

Function for PPIL6 Gene

Molecular function for PPIL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for PPIL6 Gene

Gene Ontology (GO) - Molecular Function for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
genes like me logo Genes that share ontologies with PPIL6: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PPIL6 Gene

Localization for PPIL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL6 Gene COMPARTMENTS Subcellular localization image for PPIL6 gene
Compartment Confidence
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPIL6 Gene

Pathways for PPIL6 Gene

SuperPathways for PPIL6 Gene

No Data Available

Interacting Proteins for PPIL6 Gene

Gene Ontology (GO) - Biological Process for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIL6: view

No data available for Pathways by source for PPIL6 Gene

Transcripts for PPIL6 Gene

Unigene Clusters for PPIL6 Gene

Peptidylprolyl isomerase (cyclophilin)-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: -
SP3: - - -

Relevant External Links for PPIL6 Gene

GeneLoc Exon Structure for
PPIL6
ECgene alternative splicing isoforms for
PPIL6

Expression for PPIL6 Gene

mRNA expression in normal human tissues for PPIL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPIL6 Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPIL6 Gene

SOURCE GeneReport for Unigene cluster for PPIL6 Gene Hs.32234

genes like me logo Genes that share expressions with PPIL6: view

No data available for mRNA Expression by UniProt/SwissProt for PPIL6 Gene

Orthologs for PPIL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPIL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL6 35
  • 99.7 (n)
  • 100 (a)
PPIL6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPIL6 35
  • 85.99 (n)
  • 79.15 (a)
PPIL6 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL6 35
  • 84.92 (n)
  • 79.19 (a)
PPIL6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil6 35
  • 79.14 (n)
  • 72.58 (a)
Ppil6 16
Ppil6 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIL6 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL6 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil6 35
  • 78.46 (n)
  • 72.99 (a)
chicken
(Gallus gallus)
Aves PPIL6 35
  • 66.2 (n)
  • 62.46 (a)
PPIL6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL6 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil6 35
  • 66.43 (n)
  • 64.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ppil6 35
  • 61.27 (n)
  • 58.1 (a)
ppil6 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cyn-8 36
  • 16 (a)
OneToMany
cyn-9 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for PPIL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL6 Gene

ENSEMBL:
Gene Tree for PPIL6 (if available)
TreeFam:
Gene Tree for PPIL6 (if available)

Paralogs for PPIL6 Gene

Paralogs for PPIL6 Gene

genes like me logo Genes that share paralogs with PPIL6: view

Variants for PPIL6 Gene

Sequence variations from dbSNP and Humsavar for PPIL6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs730089 -- 109,393,881(-) GAGAA(C/T)TTAAT intron-variant
rs736830 -- 109,392,096(-) TCTTA(G/T)TATAG utr-variant-3-prime, nc-transcript-variant
rs746794 -- 109,391,534(+) AATCT(C/G)TGCCC utr-variant-3-prime, nc-transcript-variant
rs1269163 -- 109,423,254(-) gagta(A/G)ctggg intron-variant
rs1273277 -- 109,423,260(-) cctcc(C/T)gagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL6 Gene

Variant ID Type Subtype PubMed ID
esv33427 CNV Loss 17666407
nsv823818 CNV Gain 20364138

Relevant External Links for PPIL6 Gene

HapMap Linkage Disequilibrium report
PPIL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL6 Gene

Disorders for PPIL6 Gene

Relevant External Links for PPIL6

Genetic Association Database (GAD)
PPIL6
Human Genome Epidemiology (HuGE) Navigator
PPIL6
genes like me logo Genes that share disorders with PPIL6: view

No data available for UniProtKB/Swiss-Prot for PPIL6 Gene

Publications for PPIL6 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PPIL6 Gene

Sources for PPIL6 Gene

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