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Aliases for PPIL6 Gene

Aliases for PPIL6 Gene

  • Peptidylprolyl Isomerase Like 6 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 6 2 3
  • Cyclophilin-Like Protein PPIL6 3 4
  • Rotamase PPIL6 3 4
  • EC 5.2.1.8 4 63
  • PPIASE 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like Variant A 3
  • Radial Spoke 12 Homolog (Chlamydomonas) 2
  • Radial Spoke 12 Homolog 3
  • BA425D10.6 3
  • DJ919F19.1 3
  • RSPH12 3

External Ids for PPIL6 Gene

Previous GeneCards Identifiers for PPIL6 Gene

  • GC06M109714
  • GC06M109759
  • GC06M109820
  • GC06M109711
  • GC06M107277

Summaries for PPIL6 Gene

GeneCards Summary for PPIL6 Gene

PPIL6 (Peptidylprolyl Isomerase Like 6) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4A.

UniProtKB/Swiss-Prot for PPIL6 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL6 Gene

Genomics for PPIL6 Gene

Regulatory Elements for PPIL6 Gene

Promoters for PPIL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIL6 Gene

Chromosome:
6
Start:
109,390,215 bp from pter
End:
109,441,171 bp from pter
Size:
50,957 bases
Orientation:
Minus strand

Genomic View for PPIL6 Gene

Genes around PPIL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL6 Gene

Proteins for PPIL6 Gene

  • Protein details for PPIL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXY8-PPIL6_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 6
    Protein Accession:
    Q8IXY8
    Secondary Accessions:
    • A9NIU0
    • A9NIU9
    • E7EX15

    Protein attributes for PPIL6 Gene

    Size:
    311 amino acids
    Molecular mass:
    35228 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPIL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL6 Gene

Proteomics data for PPIL6 Gene at MOPED

Selected DME Specific Peptides for PPIL6 Gene

Post-translational modifications for PPIL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PPIL6 Gene

Gene Families for PPIL6 Gene

Suggested Antigen Peptide Sequences for PPIL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXY8

UniProtKB/Swiss-Prot:

PPIL6_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIL6: view

Function for PPIL6 Gene

Molecular function for PPIL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIL6 Gene

Phenotypes for PPIL6 Gene

genes like me logo Genes that share phenotypes with PPIL6: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL6 Gene

Localization for PPIL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL6 Gene COMPARTMENTS Subcellular localization image for PPIL6 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPIL6 Gene

Pathways & Interactions for PPIL6 Gene

SuperPathways for PPIL6 Gene

No Data Available

Interacting Proteins for PPIL6 Gene

Gene Ontology (GO) - Biological Process for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIL6: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL6 Gene

Drugs & Compounds for PPIL6 Gene

No Compound Related Data Available

Transcripts for PPIL6 Gene

Unigene Clusters for PPIL6 Gene

Peptidylprolyl isomerase (cyclophilin)-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: -
SP3: - - -

Relevant External Links for PPIL6 Gene

GeneLoc Exon Structure for
PPIL6
ECgene alternative splicing isoforms for
PPIL6

Expression for PPIL6 Gene

mRNA expression in normal human tissues for PPIL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPIL6 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for PPIL6 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIL6 Gene



SOURCE GeneReport for Unigene cluster for PPIL6 Gene Hs.32234

genes like me logo Genes that share expression patterns with PPIL6: view

Protein tissue co-expression partners for PPIL6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PPIL6 Gene

Orthologs for PPIL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPIL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL6 35
  • 99.7 (n)
  • 100 (a)
PPIL6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPIL6 36
  • 79 (a)
OneToOne
PPIL6 35
  • 85.99 (n)
  • 79.15 (a)
dog
(Canis familiaris)
Mammalia PPIL6 35
  • 84.92 (n)
  • 79.19 (a)
PPIL6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil6 16
Ppil6 35
  • 79.14 (n)
  • 72.58 (a)
Ppil6 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIL6 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL6 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil6 35
  • 78.46 (n)
  • 72.99 (a)
chicken
(Gallus gallus)
Aves PPIL6 35
  • 66.2 (n)
  • 62.46 (a)
PPIL6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL6 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil6 35
  • 66.43 (n)
  • 64.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ppil6 36
  • 55 (a)
OneToOne
ppil6 35
  • 61.27 (n)
  • 58.1 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-8 36
  • 16 (a)
OneToMany
cyn-9 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for PPIL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL6 Gene

ENSEMBL:
Gene Tree for PPIL6 (if available)
TreeFam:
Gene Tree for PPIL6 (if available)

Paralogs for PPIL6 Gene

genes like me logo Genes that share paralogs with PPIL6: view

Variants for PPIL6 Gene

Sequence variations from dbSNP and Humsavar for PPIL6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9398200 - 109,431,248(+) CCTCG(C/T)GGGCC intron-variant, nc-transcript-variant, reference, missense
rs730089 -- 109,393,881(-) GAGAA(C/T)TTAAT intron-variant
rs736830 -- 109,392,096(-) TCTTA(G/T)TATAG nc-transcript-variant, utr-variant-3-prime
rs746794 -- 109,391,534(+) AATCT(C/G)TGCCC nc-transcript-variant, utr-variant-3-prime
rs1273277 -- 109,423,260(-) cctcc(C/T)gagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL6 Gene

Variant ID Type Subtype PubMed ID
esv33427 CNV Loss 17666407
nsv823818 CNV Gain 20364138

Variation tolerance for PPIL6 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL6 Gene

HapMap Linkage Disequilibrium report
PPIL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL6 Gene

Disorders for PPIL6 Gene

Relevant External Links for PPIL6

Genetic Association Database (GAD)
PPIL6
Human Genome Epidemiology (HuGE) Navigator
PPIL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL6

No disorders were found for PPIL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL6 Gene

Publications for PPIL6 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PPIL6 Gene

Sources for PPIL6 Gene

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