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Aliases for PPIL4 Gene

Aliases for PPIL4 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 4 2 3
  • Cyclophilin-Like Protein PPIL4 3 4
  • Rotamase PPIL4 3 4
  • EC 4 63
  • PPIASE 3 4
  • Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Serologically Defined Breast Cancer Antigen NY-BR-18 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 3
  • HDCME13P 3

External Ids for PPIL4 Gene

Previous GeneCards Identifiers for PPIL4 Gene

  • GC06M149338
  • GC06M149672
  • GC06M149760
  • GC06M149806
  • GC06M149867
  • GC06M147392

Summaries for PPIL4 Gene

Entrez Gene Summary for PPIL4 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL4 Gene

PPIL4 (Peptidylprolyl Isomerase (Cyclophilin)-Like 4) is a Protein Coding gene. Diseases associated with PPIL4 include hiv-1 and breast cancer. GO annotations related to this gene include RNA binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL4 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Gene Wiki entry for PPIL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL4 Gene

Genomics for PPIL4 Gene

Regulatory Elements for PPIL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIL4 Gene

149,504,495 bp from pter
149,546,102 bp from pter
41,608 bases
Minus strand

Genomic View for PPIL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL4 Gene

Proteins for PPIL4 Gene

  • Protein details for PPIL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 4
    Protein Accession:
    Secondary Accessions:
    • B2RD34
    • Q7Z3Q5

    Protein attributes for PPIL4 Gene

    492 amino acids
    Molecular mass:
    57225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPIL4 Gene

Proteomics data for PPIL4 Gene at MOPED

Selected DME Specific Peptides for PPIL4 Gene

Post-translational modifications for PPIL4 Gene

  • Ubiquitination at Lys201 and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PPIL4 Gene

Gene Families for PPIL4 Gene

  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for PPIL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8WUA2
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
genes like me logo Genes that share domains with PPIL4: view

Function for PPIL4 Gene

Molecular function for PPIL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIL4 Gene

Gene Ontology (GO) - Molecular Function for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PPIL4: view

Phenotypes for PPIL4 Gene

GenomeRNAi human phenotypes for PPIL4:
genes like me logo Genes that share phenotypes with PPIL4: view

Animal Model Products

CRISPR Products

miRNA for PPIL4 Gene

miRTarBase miRNAs that target PPIL4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIL4 Gene

Localization for PPIL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIL4 Gene

Subcellular locations from

Jensen Localization Image for PPIL4 Gene COMPARTMENTS Subcellular localization image for PPIL4 gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with PPIL4: view

Pathways for PPIL4 Gene

SuperPathways for PPIL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain IBA --
genes like me logo Genes that share ontologies with PPIL4: view

No data available for Pathways by source for PPIL4 Gene

Transcripts for PPIL4 Gene

mRNA/cDNA for PPIL4 Gene

Unigene Clusters for PPIL4 Gene

Peptidylprolyl isomerase (cyclophilin)-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIL4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL4 Gene

No ASD Table

Relevant External Links for PPIL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL4 Gene

mRNA expression in normal human tissues for PPIL4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL4 Gene

SOURCE GeneReport for Unigene cluster for PPIL4 Gene Hs.744238

mRNA Expression by UniProt/SwissProt for PPIL4 Gene

Tissue specificity: Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.
genes like me logo Genes that share expressions with PPIL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIL4 Gene

Orthologs for PPIL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIL4 35
  • 99.66 (n)
  • 99.8 (a)
PPIL4 36
  • 100 (a)
(Bos Taurus)
Mammalia PPIL4 35
  • 92.41 (n)
  • 97.56 (a)
PPIL4 36
  • 98 (a)
(Canis familiaris)
Mammalia PPIL4 35
  • 92.82 (n)
  • 98.17 (a)
PPIL4 36
  • 92 (a)
(Mus musculus)
Mammalia Ppil4 35
  • 91.06 (n)
  • 96.75 (a)
Ppil4 16
Ppil4 36
  • 97 (a)
(Monodelphis domestica)
Mammalia PPIL4 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia PPIL4 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Ppil4 35
  • 92.13 (n)
  • 98.6 (a)
(Gallus gallus)
Aves PPIL4 35
  • 77.48 (n)
  • 82.85 (a)
PPIL4 36
  • 77 (a)
(Anolis carolinensis)
Reptilia PPIL4 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil4 35
  • 76.94 (n)
  • 85.14 (a)
Str.5904 35
(Danio rerio)
Actinopterygii ppil4 35
  • 74.08 (n)
  • 83.91 (a)
ppil4 36
  • 74 (a)
wufi40d03 35
fruit fly
(Drosophila melanogaster)
Insecta CG5808 35
  • 60.52 (n)
  • 62.81 (a)
CG5808 36
  • 39 (a)
BcDNA:GH01073 37
  • 54 (a)
(Caenorhabditis elegans)
Secernentea sig-7 35
  • 61.25 (n)
  • 60.94 (a)
sig-7 36
  • 52 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR649W 35
  • 45.54 (n)
  • 38.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 36
  • 30 (a)
CPR5 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP59 35
  • 59.66 (n)
  • 59.55 (a)
(Oryza sativa)
Liliopsida Os.21014 35
Os06g0670500 35
  • 59.95 (n)
  • 54.77 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10166 35
  • 55.52 (n)
  • 59.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rct1 35
  • 59.7 (n)
  • 58.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5330 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5628 36
  • 50 (a)
Species with no ortholog for PPIL4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL4 Gene

Gene Tree for PPIL4 (if available)
Gene Tree for PPIL4 (if available)

Paralogs for PPIL4 Gene

Paralogs for PPIL4 Gene

Selected SIMAP similar genes for PPIL4 Gene using alignment to 4 proteins: Pseudogenes for PPIL4 Gene

genes like me logo Genes that share paralogs with PPIL4: view

Variants for PPIL4 Gene

Sequence variations from dbSNP and Humsavar for PPIL4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs761617 -- 149,534,606(+) TTTAA(C/T)AGATG intron-variant
rs950693 -- 149,517,488(-) TGGTT(G/T)TTTTA intron-variant
rs1125107 -- 149,521,558(-) caaca(A/G)actta intron-variant
rs1209587 -- 149,532,128(+) tagtc(C/G)agaaa intron-variant
rs1211939 -- 149,536,942(+) ccaac(A/G)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL4 Gene

Variant ID Type Subtype PubMed ID
nsv886762 CNV Loss 21882294

Relevant External Links for PPIL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL4 Gene

Disorders for PPIL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PPIL4 Gene including...

Search for PPIL4 Gene in MalaCards »
genes like me logo Genes that share disorders with PPIL4: view

No data available for UniProtKB/Swiss-Prot for PPIL4 Gene

Publications for PPIL4 Gene

  1. Molecular cloning, structure and expression of a novel nuclear RNA- binding cyclophilin-like gene (PPIL4) from human fetal brain. (PMID: 11978968) Zeng L. … Mao Y. (Cytogenet. Cell Genet. 2001) 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for PPIL4 Gene

Sources for PPIL4 Gene

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