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PPIL4 Gene

protein-coding   GIFtS: 53
GCID: GC06M149867

Peptidylprolyl Isomerase (Cyclophilin)-Like 4

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase (Cyclophilin)-Like 41 2     HDCME13P2
Cyclophilin-Like Protein PPIL42 3     Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase2
Rotamase PPIL42 3     Peptidyl-Prolyl Cis-Trans Isomerase-Like 42
PPIase2 3     Serologically Defined Breast Cancer Antigen NY-BR-182
EC 5.2.1.83 8     

External Ids:    HGNC: 157021   Entrez Gene: 853132   Ensembl: ENSG000001310137   OMIM: 6076095   UniProtKB: Q8WUA23   

Export aliases for PPIL4 gene to outside databases

Previous GC identifers: GC06M149338 GC06M149672 GC06M149760 GC06M149806 GC06M147392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPIL4 Gene:
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly
conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A,
and infection of HIV-1 virions. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPIL4 Gene:
PPIL4 (peptidylprolyl isomerase (cyclophilin)-like 4) is a protein-coding gene. Diseases associated with PPIL4 include hiv-1, and gout. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and RNA binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides (By similarity)

Gene Wiki entry for PPIL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PPIL4 gene promoter:
         Elk-1   Pbx1a   NRSF form 2   HNF-3beta   CREB   PPAR-gamma1   FAC1   deltaCREB   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIL4 promoter sequence
   Search Chromatin IP Primers for PPIL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

PPIL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIL4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M149867:  view genomic region     (about GC identifiers)

Start:
149,825,631 bp from pter      End:
149,867,238 bp from pter
Size:
41,608 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase-like 4  
Size: 492 amino acids; 57225 Da
Secondary accessions: B2RD34 Q7Z3Q5

Explore the universe of human proteins at neXtProt for PPIL4: NX_Q8WUA2

Explore proteomics data for PPIL4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys201, Lys300
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIL4 (Q8WUA2) (see all 7)
     GDPTGTG  QTGDPTG  SCEVIRD  VDFSQSV 


    See PPIL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_624311.1  
    ENSEMBL proteins: 
     ENSP00000253329   ENSP00000344128  

    PPIL4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PPIL4
    OriGene Custom MassSpec
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    Novus Biologicals PPIL4 Proteins
    Novus Biologicals PPIL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPIL4
    Cloud-Clone Corp. Proteins for PPIL4

    PPIL4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPIL4
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    Abcam antibodies for PPIL4
    Cloud-Clone Corp. Antibodies for PPIL4
    ThermoFisher Antibodies for PPIL4
    LSBio Antibodies in human, mouse, rat for PPIL4

    PPIL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPIL4
    Cloud-Clone Corp. CLIAs for PPIL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8WUA2

    ProtoNet protein and cluster: Q8WUA2

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002130 Peptidyl-prolyl cis-trans isomerase


    UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    PPIL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIL4_HUMAN, Q8WUA2
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides (By similarity)
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    PPIL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPIL4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPIL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIL4

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPIL4:
    hsa-mir-877-5p (MIRT037278), hsa-mir-320a (MIRT044617)

    Block miRNA regulation of human, mouse, rat PPIL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPIL4 (see all 26):
    hsa-miR-30c hsa-miR-300 hsa-miR-520d-5p hsa-miR-15a hsa-miR-30d hsa-miR-410 hsa-miR-548l hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPPIL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPIL4
    Predesigned siRNA for gene silencing in human, mouse, rat PPIL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPIL4

    Clone
    Products:
         
    OriGene clones in human, mouse for PPIL4 (see all 8)
    OriGene ORF clones in mouse, rat for PPIL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIL4 (NM_139126)
    Sino Biological Human cDNA Clone for PPIL4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PPIL4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIL4_HUMAN, Q8WUA2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    PPIL4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIL4
    Interactions:

        Search GeneGlobe Interaction Network for PPIL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for PPIL4 (Q8WUA22, 3 ENSP000002533294) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD5Q997172, 3MINT-61839 I2D: score=3 
    CHERPQ8IWX82, ENSP000001989394MINT-8334714 STRING: ENSP00000198939
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    PRPF38BENSP000003590424STRING: ENSP00000359042
    SNW1ENSP000002615314STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--

    PPIL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIL4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPIL4 gene: 
    NM_139126.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253329(uc003qmo.2 uc003qmp.2) ENST00000340881
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPIL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPIL4 (see all 26):
    hsa-miR-30c hsa-miR-300 hsa-miR-520d-5p hsa-miR-15a hsa-miR-30d hsa-miR-410 hsa-miR-548l hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPPIL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPIL4
    Predesigned siRNA for gene silencing in human, mouse, rat PPIL4
    Clone
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    OriGene clones in human, mouse for PPIL4 (see all 8)
    OriGene ORF clones in mouse, rat for PPIL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIL4 (NM_139126)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPIL4
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIL4
      QuantiTect SYBR Green Assays in human, mouse, rat PPIL4
      QuantiFast Probe-based Assays in human, mouse, rat PPIL4

    Selected AceView cDNA sequences (see all 154):

    AK092069 BE887609 BC020986 CB160587 CA418740 BC064134 BM759666 AI915665 
    BM757769 BE670173 AI880208 AA053882 BC016984 AX747342 AI720056 AA132257 
    BQ185821 AA346646 BU076634 CA441139 AF357880 CN478570 AA425562 BQ007972 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATCAAAA
    PPIL4 Expression
    About this image

    PPIL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIL4 Protein Expression

    UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2
    Tissue specificity: Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult
    tissues

        Custom PCR Arrays for PPIL4
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PPIL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIL4 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppil41 , 5 peptidylprolyl isomerase (cyclophilin)-like 41, 5 91.06(n)1
    96.75(a)1
      10 (2.38 cM)5
    674181  NM_026141.31  NP_080417.21 
     77928915 
    chicken
    (Gallus gallus)
    Aves PPIL41 peptidylprolyl isomerase (cyclophilin)-like 4 77.48(n)
    82.85(a)
      421625  XM_419663.4  XP_419663.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPIL46
    peptidylprolyl isomerase (cyclophilin)-like 4
    79(a)
    1 ↔ 1
    GL343259.1(191016-216268)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.59042 Transcribed sequence with weak similarity to protein more 79.3(n)    BX736441.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi40d032 wufi40d03 77.74(n)   334319  BC056814.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH010733
    CG58081
    RNA binding3
    CG58081
    54(a)3
    60.52(n)1
    62.81(a)1
      96A233
    429571  NM_143034.41  NP_651291.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sig-71 sig-7 61.25(n)
    60.94(a)
      172664  NM_059942.5  NP_492343.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR26
    CPR56
    Peptidyl-prolyl cis-trans isomerase (cyclophilin),...
    Peptidyl-prolyl cis-trans isomerase (cyclophilin) ...
    30(a)
    27(a)
    many ↔ many
    many ↔ many
    VIII(218226-218843) YHR057C
    IV(1071880-1072557) YDR304C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP591 CYP59 59.66(n)
    59.55(a)
      841810  NM_104250.4  NP_175776.2 
    rice
    (Oryza sativa)
    Liliopsida Os.210142 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.9(n)    AK099323.1 


    ENSEMBL Gene Tree for PPIL4 (if available)
    TreeFam Gene Tree for PPIL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIL4 gene
    PPIH2  PPIC2  PPIB2  CWC272  PPWD12  PPIL22  PPIL32  PPIL12  
    9 SIMAP similar genes for PPIL4 using alignment to 4 protein entries:     PPIL4_HUMAN (see all proteins):
    PPIL3    PPIL1    PPIF    PPIA    PPIAL4D    PPIB
    PPIH    SRSF5    NKTR

    PPIL4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPIL4
    PGOHUM00000233120


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIL4 (see all 807)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408443271,2
    C--149825212(+) AAAAAC/TAGAGG 1 -- ds50010--------
    rs48957921,2
    C,F,A,H--149825264(+) CCAGAA/C/TAGAAA 1 -- ds500125NS EA NA WA CSA 2247
    rs1459253961,2
    --149825304(+) AAAAAC/TACCTG 1 -- ds50010--------
    rs782413181,2
    --149825402(+) ACAGAC/GAGAAA 1 -- ds50010--------
    rs1909118541,2
    --149825539(+) GAAAAA/CATGCC 1 -- ds50010--------
    rs1834195891,2
    --149825584(+) CACAGA/GTAAAA 1 -- ds50010--------
    rs48957931,2
    C,H--149825609(+) GAAACG/ATGAAA 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs1867215961,2
    --149825845(+) CCAAGA/GGAGGT 1 -- ut310--------
    rs1158782641,2
    C--149825977(+) AAAACG/TCAAAT 1 -- ut310--------
    rs1379533201,2
    C--149826110(+) ACATTA/TCACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPIL4 (149825631 - 149867238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPIL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886762CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIL4
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607609    OMIM disorders: --

    5 diseases for PPIL4:    
    About MalaCards
    hiv-1    gout    breast cancer    pneumonia
    malaria


    PPIL4 for disorders           About GeneDecksing


    Export disorders for PPIL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIL4 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PPIL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, structure and expression of a novel nuclear RNA- binding cyclophilin-like gene (PPIL4) from human fetal brain. (PubMed id 11978968)1, 2, 9 Zeng L.... Mao Y. (Cytogenet. Cell Genet. 2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85313 HGNC: 15702 AceView: FLJ46041 Ensembl:ENSG00000131013 euGenes: HUgn85313
    ECgene: PPIL4 H-InvDB: PPIL4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPIL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPIL4 gene:
    Search GeneIP for patents involving PPIL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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