PPIL4 Gene
protein-coding GIFtS: 51
GCID: GC06M149867
|
|
peptidylprolyl isomerase (cyclophilin)-like 4
| |
Aliases
for PPIL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peptidylprolyl Isomerase (Cyclophilin)-Like 41 2 | | HDCME13P2 | | Cyclophilin-Like Protein PPIL42 3 | | Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase2 | | Rotamase PPIL42 3 | | Peptidyl-Prolyl Cis-Trans Isomerase-Like 42 | | PPIase2 3 | | Serologically Defined Breast Cancer Antigen NY-BR-182 | | EC 5.2.1.83 8 | | |
Export aliases for PPIL4 gene to outside databasesPrevious GC identifers: GC06M149338 GC06M149672 GC06M149760 GC06M149806 GC06M147392 |
Summaries
for PPIL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPIL4:
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conservedfamily, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infectionof HIV-1 virions. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides (By similarity)
Gene Wiki entry for PPIL4
|
Genomic Views
for PPIL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPIL4 gene promoter:
Elk-1 Pbx1a NRSF form 2 HNF-3beta CREB PPAR-gamma1 FAC1 deltaCREB PPAR-gamma2 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPIL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1PPIL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M149867: view genomic region
(about GC identifiers)
Start:
|
149,825,631 bp from pter |
End:
|
149,867,174 bp from pter |
Size:
|
41,544 bases |
Orientation:
|
minus strand |
|
Proteins
for PPIL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase-like 4 Size: 492 amino acids; 57225 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RD34 Q7Z3Q5Explore the universe of human proteins at neXtProt for PPIL4: NX_Q8WUA2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUA2
4/7 DME Specific Peptides for PPIL4 (Q8WUA2) (see all 7)
PPIL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_624311.1
ENSEMBL proteins: ENSP00000253329 ENSP00000344128
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
PPIL4 for ontologies About GeneDecksing
PPIL4 Antibody Products:
Assay Products for PPIL4: |
Protein
Domains /
Families
for PPIL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPIL4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WUA2ProtoNet protein and cluster: Q8WUA2 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB002130 Peptidyl-prolyl cis-trans isomerase
UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2Similarity: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamilySimilarity: Contains 1 PPIase cyclophilin-type domainSimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for PPIL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides (By similarity)Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme Number (IUBMB): EC 5.2.1.81 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PPIL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PPIL4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PPIL4:
|
Pathways & Interactions
for PPIL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIL4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for PPIL4 (Q8WUA22, 3 ENSP000002533294) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- |
PPIL4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PPIL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PPIL4
Search CenterWatch for drugs/clinical trials and news about PPIL4
|
Transcripts
for PPIL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPIL4 gene: NM_139126.3 Unigene Cluster for PPIL4: Peptidylprolyl isomerase (cyclophilin)-like 4 Hs.744238 [show with all ESTs]Unigene Representative Sequence: NM_1391262 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253329(uc003qmo.2 uc003qmp.2) ENST00000340881
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPIL4 (NM_139126) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF068298.1 AF308286.1 AF357880.1 AK315388.1 BC016984.1 BC020986.1 BC064134.1 BC107684.1 BX537536.1 9 DOTS entries: DT.211717 DT.91920068 DT.100763576 DT.100817609 DT.100817610 DT.121396432 DT.91651145 DT.91943554 DT.95164049 24/154 AceView cDNA sequences (see all 154): BQ019209 AA346646 BX504568 CA441139 BC064134 AF357880 CA418740 CN478570 AA132362 BE887609 AA132257 CB160330 BM562747 BQ019220 BU076634 AI720056 BQ185821 AI915665 AI400941 NM_139126 AA053882 CB160587 BM759666 BC020986
GeneLoc Exon Structure
|
Expression
for PPIL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPIL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATCAAAA
About this image
See PPIL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIL4
SOURCE GeneReport for Unigene cluster: Hs.744238
UniProtKB/Swiss-Prot: PPIL4_HUMAN, Q8WUA2Tissue specificity: Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues
SABiosciences Custom PCR Arrays for PPIL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIL4
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL4 |
Orthologs
for PPIL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PPIL4 gene from 10/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPIL41 |
peptidylprolyl isomerase (cyclophilin)-like 4 |
78.17(n)
83.47(a) |
|
421625 XM_419663.3 XP_419663.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PPIL46 |
-- |
78(a) |
1 ↔ 1 |
GL343259.1(191016-216268) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.59042 |
Transcribed sequence with weak similarity to protein more |
79.3(n) |
|
BX736441.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi40d032 |
wufi40d03 |
77.74(n) |
|
334319 BC056814.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:GH010733
CG58081 |
RNA binding3
CG58081 |
54(a)3
54.89(n)1
51.45(a)1 |
|
96A233
429571 NM_143034.41 NP_651291.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
sig-71 |
Protein SIG-7 |
55.56(n)
52.88(a) |
|
172664 NM_059942.4 NP_492343.2 |
A. gossypii yeast
(Ashbya gossypii) |
Saccharomycetes |
AGOS_AFR649W1 |
AFR649Wp |
45.08(n)
38.26(a) |
|
4622485 NM_212333.1 NP_986197.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CYP591 |
cyclophilin 59 |
55.44(n)
49.05(a) |
|
841810 NM_104250.4 NP_175776.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.210142 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.9(n) |
|
AK099323.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ppiB6ppiA6 |
peptidyl-prolyl cis-trans isomerase B (rotamase B)...peptidyl-prolyl cis-trans isomerase A (rotamase A)... |
24(a)20(a) |
possible orthologpossible ortholog |
Chromosome(553166-553660) Chromosome(3489747-3490319) |
ENSEMBL Gene Tree for PPIL4 (if available)
TreeFam Gene Tree for PPIL4 (if available) |
Paralogs
for PPIL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPIL4 gene
- PPIH2 PPIB2 PPIC2 CWC272 PPWD12 PPIL12 PPIL32 PPIL22
9 SIMAP similar genes for PPIL4 using alignment to 4 protein entries: PPIL4_HUMAN (see all proteins):PPIL3 PPIL1 PPIF PPIA PPIB PPIH
SRSF5 NKTR PPIC
PPIL4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PPIL4
PGOHUM00000233120
|
Genomic Variants
for PPIL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPIL4 (149825631 - 149867174 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPIL4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIL4 |
|
Disorders
/ Diseases
for PPIL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPIL4 for disorders About GeneDecksing
OMIM gene information: 607609
OMIM disorders: --
3  diseases for PPIL4: About MalaCardsbreast cancer gout colon cancer
Export disorders for PPIL4 gene to outside databases
|
Publications
for PPIL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPIL4 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with PPIL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, structure and expression of a novel nuclear RNA- binding cyclophilin-like gene (PPIL4) from human fetal brain. (PubMed id 11978968)1, 2, 9 Zeng L.... Mao Y. (2001)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
|
External Searches for PPIL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPIL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPIL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPIL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PPIL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PPIL4 gene:
Search GeneIP for patents involving PPIL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPIL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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