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Aliases for PPIL4 Gene

Aliases for PPIL4 Gene

  • Peptidylprolyl Isomerase Like 4 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 4 2 3
  • Cyclophilin-Like Protein PPIL4 3 4
  • Rotamase PPIL4 3 4
  • EC 5.2.1.8 4 61
  • PPIASE 3 4
  • Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Serologically Defined Breast Cancer Antigen NY-BR-18 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 3
  • HDCME13P 3

External Ids for PPIL4 Gene

Previous GeneCards Identifiers for PPIL4 Gene

  • GC06M149338
  • GC06M149672
  • GC06M149760
  • GC06M149806
  • GC06M149867
  • GC06M147392

Summaries for PPIL4 Gene

Entrez Gene Summary for PPIL4 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL4 Gene

PPIL4 (Peptidylprolyl Isomerase Like 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CWC27.

UniProtKB/Swiss-Prot for PPIL4 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Gene Wiki entry for PPIL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL4 Gene

Genomics for PPIL4 Gene

Regulatory Elements for PPIL4 Gene

Enhancers for PPIL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F149646 0.7 ENCODE 35.1 -101.8 -101787 3.4 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ENSG00000231760 PPIL4 LATS1 ENSG00000233330 RPS18P9 GINM1 KATNA1 ENSG00000207292
GH06F149962 1.4 FANTOM5 ENCODE 31.9 -418.1 -418097 3.1 PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF548 FOS KLF13 LATS1 NUP43 KATNA1 PPIL4 ULBP1 RAET1K ENSG00000235972 PHBP1 ENSG00000231760 ENSG00000219298
GH06F149745 0.7 ENCODE 27 -200.3 -200309 2.0 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 FOS ENSG00000231760 PPIL4 LATS1 LRP11 NUP43 GINM1 ENSG00000233330 ENSG00000216906 PCMT1
GH06F150335 0.7 ENCODE 26.6 -790.1 -790054 1.9 CBX3 PKNOX1 TBL1XR1 WRNIP1 BMI1 ZNF2 RAD21 FOS ZNF654 USF2 LATS1 PPIL4 NUP43 ENSG00000231760 ENSG00000233330 RPL32P16 GINM1 RNU4-7P GC06M150158
GH06F150266 1.3 FANTOM5 Ensembl ENCODE 25.9 -724.3 -724268 8.3 HDGF PKNOX1 ARNT FEZF1 ZNF2 YY1 CBX5 ZNF416 FOS KLF13 LATS1 NUP43 PPIL4 KATNA1 ENSG00000231760 RNU4-7P RPS18P9 ENSG00000202343 ENSG00000238594 ENSG00000233330
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPIL4 on UCSC Golden Path with GeneCards custom track

Promoters for PPIL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001230460 202 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for PPIL4 Gene

Chromosome:
6
Start:
149,504,495 bp from pter
End:
149,546,102 bp from pter
Size:
41,608 bases
Orientation:
Minus strand

Genomic View for PPIL4 Gene

Genes around PPIL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL4 Gene

Proteins for PPIL4 Gene

  • Protein details for PPIL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA2-PPIL4_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 4
    Protein Accession:
    Q8WUA2
    Secondary Accessions:
    • B2RD34
    • Q7Z3Q5

    Protein attributes for PPIL4 Gene

    Size:
    492 amino acids
    Molecular mass:
    57225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPIL4 Gene

Selected DME Specific Peptides for PPIL4 Gene

Q8WUA2:
  • LEMVGDLP
  • SCEVIRD
  • VDFSQSV
  • GDPTGTG
  • QTGDPTG
  • HTVILDDP
  • LFVCKLNPVT

Post-translational modifications for PPIL4 Gene

  • Ubiquitination at Lys 201 and Lys 300
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PPIL4
  • Santa Cruz Biotechnology (SCBT) Antibodies for PPIL4

Domains & Families for PPIL4 Gene

Suggested Antigen Peptide Sequences for PPIL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUA2

UniProtKB/Swiss-Prot:

PPIL4_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
genes like me logo Genes that share domains with PPIL4: view

Function for PPIL4 Gene

Molecular function for PPIL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIL4 Gene

Gene Ontology (GO) - Molecular Function for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL4: view
genes like me logo Genes that share phenotypes with PPIL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIL4

miRNA for PPIL4 Gene

miRTarBase miRNAs that target PPIL4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL4 Gene

Localization for PPIL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL4 Gene COMPARTMENTS Subcellular localization image for PPIL4 gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PPIL4: view

Pathways & Interactions for PPIL4 Gene

SuperPathways for PPIL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIL4: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL4 Gene

Transcripts for PPIL4 Gene

mRNA/cDNA for PPIL4 Gene

Unigene Clusters for PPIL4 Gene

Peptidylprolyl isomerase (cyclophilin)-like 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL4 Gene

No ASD Table

Relevant External Links for PPIL4 Gene

GeneLoc Exon Structure for
PPIL4
ECgene alternative splicing isoforms for
PPIL4

Expression for PPIL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIL4 Gene

Protein differential expression in normal tissues from HIPED for PPIL4 Gene

This gene is overexpressed in Adrenal (28.2) and Peripheral blood mononuclear cells (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIL4 Gene



Protein tissue co-expression partners for PPIL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL4 Gene:

PPIL4

SOURCE GeneReport for Unigene cluster for PPIL4 Gene:

Hs.744238

mRNA Expression by UniProt/SwissProt for PPIL4 Gene:

Q8WUA2-PPIL4_HUMAN
Tissue specificity: Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.
genes like me logo Genes that share expression patterns with PPIL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIL4 Gene

Orthologs for PPIL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL4 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia PPIL4 34 35
  • 92.82 (n)
cow
(Bos Taurus)
Mammalia PPIL4 34 35
  • 92.41 (n)
rat
(Rattus norvegicus)
Mammalia Ppil4 34
  • 92.13 (n)
mouse
(Mus musculus)
Mammalia Ppil4 34 16 35
  • 91.06 (n)
oppossum
(Monodelphis domestica)
Mammalia PPIL4 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL4 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL4 34 35
  • 77.48 (n)
lizard
(Anolis carolinensis)
Reptilia PPIL4 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil4 34
  • 76.94 (n)
Str.5904 34
zebrafish
(Danio rerio)
Actinopterygii ppil4 34 35
  • 74.08 (n)
wufi40d03 34
fruit fly
(Drosophila melanogaster)
Insecta CG5808 34 35
  • 60.52 (n)
BcDNA:GH01073 36
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea sig-7 34 35
  • 61.25 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR649W 34
  • 45.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 35
  • 30 (a)
ManyToMany
CPR5 35
  • 27 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP59 34
  • 59.66 (n)
rice
(Oryza sativa)
Liliopsida Os06g0670500 34
  • 59.95 (n)
Os.21014 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rct1 34
  • 59.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10166 34
  • 55.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5628 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5330 34
Species where no ortholog for PPIL4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL4 Gene

ENSEMBL:
Gene Tree for PPIL4 (if available)
TreeFam:
Gene Tree for PPIL4 (if available)

Paralogs for PPIL4 Gene

Paralogs for PPIL4 Gene

(9) SIMAP similar genes for PPIL4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PPIL4 Gene

genes like me logo Genes that share paralogs with PPIL4: view

Variants for PPIL4 Gene

Sequence variations from dbSNP and Humsavar for PPIL4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10485097 -- 149,524,514(+) ACCCA(A/G)TTCAG intron-variant
rs10658117 -- 149,510,081(+) CCACC(-/ACT)GATTC intron-variant
rs111335846 -- 149,517,812(+) AAGTT(G/T)GAGAG intron-variant
rs111346296 -- 149,520,751(+) GCTCA(C/T)GCCTG intron-variant
rs111441044 -- 149,520,682(+) ATTAA(A/C)AGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL4 Gene

Variant ID Type Subtype PubMed ID
esv3359949 CNV insertion 20981092

Variation tolerance for PPIL4 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL4 Gene

Disorders for PPIL4 Gene

Relevant External Links for PPIL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL4

No disorders were found for PPIL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL4 Gene

Publications for PPIL4 Gene

  1. Molecular cloning, structure and expression of a novel nuclear RNA- binding cyclophilin-like gene (PPIL4) from human fetal brain. (PMID: 11978968) Zeng L. … Mao Y. (Cytogenet. Cell Genet. 2001) 3 4 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for PPIL4 Gene

Sources for PPIL4 Gene

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