Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPIL4 Gene

Aliases for PPIL4 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 4 2 3
  • Cyclophilin-Like Protein PPIL4 3 4
  • Rotamase PPIL4 3 4
  • EC 5.2.1.8 4 63
  • PPIASE 3 4
  • Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Serologically Defined Breast Cancer Antigen NY-BR-18 3
  • HDCME13P 3

External Ids for PPIL4 Gene

Previous GeneCards Identifiers for PPIL4 Gene

  • GC06M149338
  • GC06M149672
  • GC06M149760
  • GC06M149806
  • GC06M149867
  • GC06M147392

Summaries for PPIL4 Gene

Entrez Gene Summary for PPIL4 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL4 Gene

PPIL4 (Peptidylprolyl Isomerase (Cyclophilin)-Like 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL4 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Gene Wiki entry for PPIL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL4 Gene

Genomics for PPIL4 Gene

Regulatory Elements for PPIL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIL4 Gene

Chromosome:
6
Start:
149,504,495 bp from pter
End:
149,546,102 bp from pter
Size:
41,608 bases
Orientation:
Minus strand

Genomic View for PPIL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL4 Gene

Proteins for PPIL4 Gene

  • Protein details for PPIL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA2-PPIL4_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 4
    Protein Accession:
    Q8WUA2
    Secondary Accessions:
    • B2RD34
    • Q7Z3Q5

    Protein attributes for PPIL4 Gene

    Size:
    492 amino acids
    Molecular mass:
    57225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPIL4 Gene

Proteomics data for PPIL4 Gene at MOPED

Selected DME Specific Peptides for PPIL4 Gene

Post-translational modifications for PPIL4 Gene

  • Ubiquitination at Lys 201 and Lys 300
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PPIL4 Gene

Suggested Antigen Peptide Sequences for PPIL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUA2

UniProtKB/Swiss-Prot:

PPIL4_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
genes like me logo Genes that share domains with PPIL4: view

Function for PPIL4 Gene

Molecular function for PPIL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIL4 Gene

Gene Ontology (GO) - Molecular Function for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PPIL4: view
genes like me logo Genes that share phenotypes with PPIL4: view

Animal Model Products

miRNA for PPIL4 Gene

miRTarBase miRNAs that target PPIL4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIL4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL4 Gene

Localization for PPIL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL4 Gene COMPARTMENTS Subcellular localization image for PPIL4 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PPIL4: view

Pathways & Interactions for PPIL4 Gene

SuperPathways for PPIL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain IBA --
genes like me logo Genes that share ontologies with PPIL4: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL4 Gene

Drugs & Compounds for PPIL4 Gene

No Compound Related Data Available

Transcripts for PPIL4 Gene

mRNA/cDNA for PPIL4 Gene

Unigene Clusters for PPIL4 Gene

Peptidylprolyl isomerase (cyclophilin)-like 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL4 Gene

No ASD Table

Relevant External Links for PPIL4 Gene

GeneLoc Exon Structure for
PPIL4
ECgene alternative splicing isoforms for
PPIL4

Expression for PPIL4 Gene

mRNA expression in normal human tissues for PPIL4 Gene

Protein differential expression in normal tissues from HIPED for PPIL4 Gene

This gene is overexpressed in Adrenal (28.2) and Peripheral blood mononuclear cells (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL4 Gene



SOURCE GeneReport for Unigene cluster for PPIL4 Gene Hs.744238

mRNA Expression by UniProt/SwissProt for PPIL4 Gene

Q8WUA2-PPIL4_HUMAN
Tissue specificity: Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.
genes like me logo Genes that share expression patterns with PPIL4: view

Protein tissue co-expression partners for PPIL4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIL4 Gene

Orthologs for PPIL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIL4 35
  • 92.41 (n)
  • 97.56 (a)
PPIL4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL4 35
  • 92.82 (n)
  • 98.17 (a)
PPIL4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil4 35
  • 91.06 (n)
  • 96.75 (a)
Ppil4 16
Ppil4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIL4 35
  • 99.66 (n)
  • 99.8 (a)
PPIL4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil4 35
  • 92.13 (n)
  • 98.6 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIL4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL4 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL4 35
  • 77.48 (n)
  • 82.85 (a)
PPIL4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil4 35
  • 76.94 (n)
  • 85.14 (a)
Str.5904 35
zebrafish
(Danio rerio)
Actinopterygii ppil4 35
  • 74.08 (n)
  • 83.91 (a)
wufi40d03 35
ppil4 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH01073 37
  • 54 (a)
CG5808 35
  • 60.52 (n)
  • 62.81 (a)
CG5808 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sig-7 35
  • 61.25 (n)
  • 60.94 (a)
sig-7 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR649W 35
  • 45.54 (n)
  • 38.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 36
  • 30 (a)
ManyToMany
CPR5 36
  • 27 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP59 35
  • 59.66 (n)
  • 59.55 (a)
rice
(Oryza sativa)
Liliopsida Os.21014 35
Os06g0670500 35
  • 59.95 (n)
  • 54.77 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5330 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10166 35
  • 55.52 (n)
  • 59.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rct1 35
  • 59.7 (n)
  • 58.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5628 36
  • 50 (a)
OneToOne
Species with no ortholog for PPIL4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL4 Gene

ENSEMBL:
Gene Tree for PPIL4 (if available)
TreeFam:
Gene Tree for PPIL4 (if available)

Paralogs for PPIL4 Gene

Paralogs for PPIL4 Gene

(9) SIMAP similar genes for PPIL4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PPIL4 Gene

genes like me logo Genes that share paralogs with PPIL4: view

Variants for PPIL4 Gene

Sequence variations from dbSNP and Humsavar for PPIL4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs761617 -- 149,534,606(+) TTTAA(C/T)AGATG intron-variant
rs1125107 -- 149,521,558(-) caaca(A/G)actta intron-variant
rs74367049 -- 149,505,299(+) CTTTC(A/C/T)GTGCT utr-variant-3-prime
rs74456648 -- 149,528,813(+) CAAAT(A/G)TTTAC intron-variant
rs74475407 -- 149,537,125(+) TGTCT(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL4 Gene

Variant ID Type Subtype PubMed ID
nsv886762 CNV Loss 21882294

Variation tolerance for PPIL4 Gene

Residual Variation Intolerance Score: 32.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL4 Gene

HapMap Linkage Disequilibrium report
PPIL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL4 Gene

Disorders for PPIL4 Gene

Relevant External Links for PPIL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL4
genes like me logo Genes that share disorders with PPIL4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL4 Gene

Publications for PPIL4 Gene

  1. Molecular cloning, structure and expression of a novel nuclear RNA- binding cyclophilin-like gene (PPIL4) from human fetal brain. (PMID: 11978968) Zeng L. … Mao Y. (Cytogenet. Cell Genet. 2001) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for PPIL4 Gene

Sources for PPIL4 Gene

Back to Top

Content