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Aliases for PPIL3 Gene

Aliases for PPIL3 Gene

  • Peptidylprolyl Isomerase Like 3 2 3 5
  • Cyclophilin J 2 3 4
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 3 2 3
  • Cyclophilin-Like Protein PPIL3 3 4
  • Rotamase PPIL3 3 4
  • EC 5.2.1.8 4 63
  • PPIASE 3 4
  • CYPJ 3 4
  • Peptidylprolyl Cis-Trans Isomerase-Like Protein 3 3
  • Peptidylprolyl Isomerase -Like 3 3
  • Cyclophilin-Like Protein 3 3
  • PPIase-Like Protein 3 3

External Ids for PPIL3 Gene

Previous GeneCards Identifiers for PPIL3 Gene

  • GC02M199952
  • GC02M200460
  • GC02M201699
  • GC02M201938
  • GC02M201561
  • GC02M201443
  • GC02M201736
  • GC02M201718
  • GC02M193587
  • GC02M201737

Summaries for PPIL3 Gene

Entrez Gene Summary for PPIL3 Gene

  • This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

GeneCards Summary for PPIL3 Gene

PPIL3 (Peptidylprolyl Isomerase Like 3) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL3 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL3 Gene

Genomics for PPIL3 Gene

Regulatory Elements for PPIL3 Gene

Enhancers for PPIL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIL3 on UCSC Golden Path with GeneCards custom track

Promoters for PPIL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIL3 Gene

Chromosome:
2
Start:
200,870,907 bp from pter
End:
200,889,333 bp from pter
Size:
18,427 bases
Orientation:
Minus strand

Genomic View for PPIL3 Gene

Genes around PPIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL3 Gene

Proteins for PPIL3 Gene

  • Protein details for PPIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H8-PPIL3_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 3
    Protein Accession:
    Q9H2H8
    Secondary Accessions:
    • Q86WF9
    • Q96IA9
    • Q9BXZ1

    Protein attributes for PPIL3 Gene

    Size:
    161 amino acids
    Molecular mass:
    18155 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPIL3 Gene

    Alternative splice isoforms for PPIL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL3 Gene

Proteomics data for PPIL3 Gene at MOPED

Post-translational modifications for PPIL3 Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Domains & Families for PPIL3 Gene

Gene Families for PPIL3 Gene

Suggested Antigen Peptide Sequences for PPIL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2H8

UniProtKB/Swiss-Prot:

PPIL3_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
genes like me logo Genes that share domains with PPIL3: view

Function for PPIL3 Gene

Molecular function for PPIL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIL3 Gene

genes like me logo Genes that share phenotypes with PPIL3: view

Animal Models for PPIL3 Gene

MGI Knock Outs for PPIL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIL3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIL3 Gene

Localization for PPIL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL3 Gene COMPARTMENTS Subcellular localization image for PPIL3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL3 Gene

Pathways & Interactions for PPIL3 Gene

SuperPathways for PPIL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL3 Gene

Drugs & Compounds for PPIL3 Gene

No Compound Related Data Available

Transcripts for PPIL3 Gene

Unigene Clusters for PPIL3 Gene

Peptidylprolyl isomerase (cyclophilin)-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL3 Gene

No ASD Table

Relevant External Links for PPIL3 Gene

GeneLoc Exon Structure for
PPIL3
ECgene alternative splicing isoforms for
PPIL3

Expression for PPIL3 Gene

mRNA expression in normal human tissues for PPIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIL3 Gene

This gene is overexpressed in Lavage (10.0), Nasal epithelium (8.9), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL3 Gene



SOURCE GeneReport for Unigene cluster for PPIL3 Gene Hs.121076

mRNA Expression by UniProt/SwissProt for PPIL3 Gene

Q9H2H8-PPIL3_HUMAN
Tissue specificity: Ubiquitous. Detected at low levels.
genes like me logo Genes that share expression patterns with PPIL3: view

Protein tissue co-expression partners for PPIL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPIL3 Gene

Orthologs for PPIL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIL3 35
  • 92.96 (n)
  • 99.38 (a)
PPIL3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL3 35
  • 94.41 (n)
  • 100 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppil3 35
  • 93.37 (n)
  • 98.14 (a)
Ppil3 16
Ppil3 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIL3 35
  • 99.59 (n)
  • 100 (a)
PPIL3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil3 35
  • 92.75 (n)
  • 98.76 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIL3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL3 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL3 35
  • 81.46 (n)
  • 95 (a)
PPIL3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil3 35
  • 74.58 (n)
  • 86.25 (a)
Str.17154 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16990 35
zgc:86715 35
  • 76.67 (n)
  • 84.37 (a)
PPIL3 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3441 35
fruit fly
(Drosophila melanogaster)
Insecta CG11777 37
  • 53 (a)
CG11777 35
  • 67.08 (n)
  • 71.87 (a)
CG11777 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009996 35
  • 65.62 (n)
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-10 37
  • 49 (a)
cyn-10 35
  • 65.62 (n)
  • 70.44 (a)
cyn-10 36
  • 55 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01940 35
  • 65.62 (n)
  • 67.3 (a)
rice
(Oryza sativa)
Liliopsida Os06g0130500 35
  • 61.43 (n)
  • 69.81 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12592 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10388 35
  • 57.5 (n)
  • 61.87 (a)
Species with no ortholog for PPIL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL3 Gene

ENSEMBL:
Gene Tree for PPIL3 (if available)
TreeFam:
Gene Tree for PPIL3 (if available)

Paralogs for PPIL3 Gene

Paralogs for PPIL3 Gene

genes like me logo Genes that share paralogs with PPIL3: view

Variants for PPIL3 Gene

Sequence variations from dbSNP and Humsavar for PPIL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs7562391 - 200,871,443(+) TGTAC(A/C)TCATT reference, missense
rs3731718 -- 200,876,927(-) ACCGT(A/G)TTTGG reference, synonymous-codon
rs6747253 -- 200,883,692(+) catga(A/G)ggtaa intron-variant
rs2136600 -- 200,877,622(+) GGAGG(C/T)TGGAC intron-variant
rs6754769 -- 200,885,129(+) acttt(C/G)ggagg intron-variant

Variation tolerance for PPIL3 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL3 Gene

HapMap Linkage Disequilibrium report
PPIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPIL3 Gene

Disorders for PPIL3 Gene

Relevant External Links for PPIL3

Genetic Association Database (GAD)
PPIL3
Human Genome Epidemiology (HuGE) Navigator
PPIL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL3

No disorders were found for PPIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL3 Gene

Publications for PPIL3 Gene

  1. Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. (PMID: 11435694) Zhou Z. … Mao Y. (Cytogenet. Cell Genet. 2001) 2 3 4 23 67
  2. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. (PMID: 18474220) Huo D.H. … Yang J. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. (PMID: 26020957) Chen J. … Yu L. (PLoS ONE 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PPIL3 Gene

Sources for PPIL3 Gene

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