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Aliases for PPIL3 Gene

Aliases for PPIL3 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 3 2 3
  • Cyclophilin J 2 3 4
  • Cyclophilin-Like Protein PPIL3 3 4
  • Rotamase PPIL3 3 4
  • EC 4 63
  • PPIASE 3 4
  • CYPJ 3 4
  • Peptidylprolyl Cis-Trans Isomerase-Like Protein 3 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 3 3
  • Cyclophilin-Like Protein 3 3
  • PPIase-Like Protein 3 3

External Ids for PPIL3 Gene

Previous GeneCards Identifiers for PPIL3 Gene

  • GC02M199952
  • GC02M200460
  • GC02M201699
  • GC02M201938
  • GC02M201561
  • GC02M201443
  • GC02M201736
  • GC02M201718
  • GC02M193587
  • GC02M201737

Summaries for PPIL3 Gene

Entrez Gene Summary for PPIL3 Gene

  • This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

GeneCards Summary for PPIL3 Gene

PPIL3 (Peptidylprolyl Isomerase (Cyclophilin)-Like 3) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL3 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

Gene Wiki entry for PPIL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL3 Gene

Genomics for PPIL3 Gene

Regulatory Elements for PPIL3 Gene

Genomic Location for PPIL3 Gene

200,870,907 bp from pter
200,889,326 bp from pter
18,420 bases
Minus strand

Genomic View for PPIL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL3 Gene

Proteins for PPIL3 Gene

  • Protein details for PPIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 3
    Protein Accession:
    Secondary Accessions:
    • Q86WF9
    • Q96IA9
    • Q9BXZ1

    Protein attributes for PPIL3 Gene

    161 amino acids
    Molecular mass:
    18155 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPIL3 Gene

    Alternative splice isoforms for PPIL3 Gene


neXtProt entry for PPIL3 Gene

Proteomics data for PPIL3 Gene at MOPED

Post-translational modifications for PPIL3 Gene

  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

Domains for PPIL3 Gene

Suggested Antigen Peptide Sequences for PPIL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H2H8
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
genes like me logo Genes that share domains with PPIL3: view

No data available for Gene Families for PPIL3 Gene

Function for PPIL3 Gene

Molecular function for PPIL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for PPIL3 Gene

Gene Ontology (GO) - Molecular Function for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PPIL3: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PPIL3 Gene

Localization for PPIL3 Gene

Subcellular locations from

Jensen Localization Image for PPIL3 Gene COMPARTMENTS Subcellular localization image for PPIL3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL3 Gene

Pathways for PPIL3 Gene

SuperPathways for PPIL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Pathways by source for PPIL3 Gene

Transcripts for PPIL3 Gene

Unigene Clusters for PPIL3 Gene

Peptidylprolyl isomerase (cyclophilin)-like 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL3 Gene

No ASD Table

Relevant External Links for PPIL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL3 Gene

mRNA expression in normal human tissues for PPIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL3 Gene

SOURCE GeneReport for Unigene cluster for PPIL3 Gene Hs.121076

mRNA Expression by UniProt/SwissProt for PPIL3 Gene

Tissue specificity: Ubiquitous. Detected at low levels.
genes like me logo Genes that share expressions with PPIL3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPIL3 Gene

Orthologs for PPIL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIL3 35
  • 99.59 (n)
  • 100 (a)
PPIL3 36
  • 96 (a)
(Bos Taurus)
Mammalia PPIL3 35
  • 92.96 (n)
  • 99.38 (a)
PPIL3 36
  • 79 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
-- 36
  • 84 (a)
PPIL3 35
  • 94.41 (n)
  • 100 (a)
(Mus musculus)
Mammalia Ppil3 35
  • 93.37 (n)
  • 98.14 (a)
Ppil3 16
Ppil3 36
  • 83 (a)
(Monodelphis domestica)
Mammalia PPIL3 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia PPIL3 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Ppil3 35
  • 92.75 (n)
  • 98.76 (a)
(Gallus gallus)
Aves PPIL3 35
  • 81.46 (n)
  • 95 (a)
PPIL3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia PPIL3 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil3 35
  • 74.58 (n)
  • 86.25 (a)
Str.17154 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3441 35
(Danio rerio)
Actinopterygii Dr.16990 35
PPIL3 36
  • 70 (a)
zgc:86715 35
  • 76.67 (n)
  • 84.37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009996 35
  • 65.62 (n)
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11777 35
  • 67.08 (n)
  • 71.87 (a)
CG11777 36
  • 58 (a)
CG11777 37
  • 53 (a)
(Caenorhabditis elegans)
Secernentea cyn-10 35
  • 65.62 (n)
  • 70.44 (a)
cyn-10 36
  • 55 (a)
cyp-10 37
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01940 35
  • 65.62 (n)
  • 67.3 (a)
(Oryza sativa)
Liliopsida Os06g0130500 35
  • 61.43 (n)
  • 69.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10388 35
  • 57.5 (n)
  • 61.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12592 35
Species with no ortholog for PPIL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL3 Gene

Gene Tree for PPIL3 (if available)
Gene Tree for PPIL3 (if available)

Paralogs for PPIL3 Gene

Paralogs for PPIL3 Gene

genes like me logo Genes that share paralogs with PPIL3: view

Variants for PPIL3 Gene

Sequence variations from dbSNP and Humsavar for PPIL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2136600 -- 200,877,622(+) GGAGG(C/T)TGGAC intron-variant
rs2301981 -- 200,885,878(-) CTGTC(C/T)GTTTT intron-variant
rs3731718 -- 200,876,927(-) ACCGT(A/G)TTTGG reference, synonymous-codon
rs4035021 -- 200,874,604(+) ATCCA(A/G)TAAAA intron-variant
rs4035022 -- 200,879,629(+) cagga(A/G)tttca intron-variant

Relevant External Links for PPIL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPIL3 Gene

Disorders for PPIL3 Gene

Relevant External Links for PPIL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PPIL3: view

No data available for UniProtKB/Swiss-Prot for PPIL3 Gene

Publications for PPIL3 Gene

  1. Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. (PMID: 11435694) Zhou Z. … Mao Y. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  2. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. (PMID: 18474220) Huo D.H. … Yang J. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPIL3 Gene

Sources for PPIL3 Gene

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