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Aliases for PPIL3 Gene

Aliases for PPIL3 Gene

  • Peptidylprolyl Isomerase Like 3 2 3 5
  • Cyclophilin J 2 3 4
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 3 2 3
  • Cyclophilin-Like Protein PPIL3 3 4
  • Rotamase PPIL3 3 4
  • EC 5.2.1.8 4 61
  • PPIASE 3 4
  • CYPJ 3 4
  • Peptidylprolyl Cis-Trans Isomerase-Like Protein 3 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 3 3
  • Cyclophilin-Like Protein 3 3
  • PPIase-Like Protein 3 3

External Ids for PPIL3 Gene

Previous GeneCards Identifiers for PPIL3 Gene

  • GC02M199952
  • GC02M200460
  • GC02M201699
  • GC02M201938
  • GC02M201561
  • GC02M201443
  • GC02M201736
  • GC02M201718
  • GC02M193587
  • GC02M201737

Summaries for PPIL3 Gene

Entrez Gene Summary for PPIL3 Gene

  • This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

GeneCards Summary for PPIL3 Gene

PPIL3 (Peptidylprolyl Isomerase Like 3) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIL2.

UniProtKB/Swiss-Prot for PPIL3 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL3 Gene

Genomics for PPIL3 Gene

Regulatory Elements for PPIL3 Gene

Enhancers for PPIL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F200887 0.2 ENCODE 87.5 +0.1 146 3.6 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 PPIL3 TYW5 ORC2 KCTD18 RNU6-762P SPATS2L LOC100420110 NIF3L1 RNU6-312P
GH02F200866 0.6 ENCODE 83.7 +22.1 22111 1.1 TBP INSM2 FEZF1 GTF3C2 ZNF366 ZNF548 ZNF362 CEBPB ZEB2 ZNF843 PPIL3 ORC2 RNU6-762P TYW5 LOC100420110 CLK1 RNU6-312P
GH02F200962 1 FANTOM5 ENCODE 81.4 -74.5 -74474 3.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 PPIL3 ORC2 KCTD18 CLK1 CASP8 FAM126B NIF3L1 CFLAR HNRNPA1P35
GH02F200901 1 ENCODE 78.6 -12.2 -12242 0.8 ELF3 CTCF ZNF146 SAP130 ARID4B MAX ZSCAN9 ZNF2 RAD21 ZNF143 PPIL3 CASP10 CFLAR-AS1 ORC2 LOC105373835 RNU6-762P GC02M200915
GH02F201114 1 FANTOM5 ENCODE 73.3 -234.9 -234883 19.0 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D PPIL3 CFLAR ORC2 CASP10 LOC100130026 CLK1 CFLAR-AS1 FAM126B LOC105373835 LOC100420110
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPIL3 on UCSC Golden Path with GeneCards custom track

Promoters for PPIL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000605450 333 3201 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for PPIL3 Gene

Chromosome:
2
Start:
200,870,907 bp from pter
End:
200,889,333 bp from pter
Size:
18,427 bases
Orientation:
Minus strand

Genomic View for PPIL3 Gene

Genes around PPIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL3 Gene

Proteins for PPIL3 Gene

  • Protein details for PPIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H8-PPIL3_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 3
    Protein Accession:
    Q9H2H8
    Secondary Accessions:
    • Q86WF9
    • Q96IA9
    • Q9BXZ1

    Protein attributes for PPIL3 Gene

    Size:
    161 amino acids
    Molecular mass:
    18155 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPIL3 Gene

    Alternative splice isoforms for PPIL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL3 Gene

Selected DME Specific Peptides for PPIL3 Gene

Q9H2H8:
  • VTLHTDVGDIKIE
  • FHRNIKGFM
  • TNGSQFF
  • GDPTGTG
  • QTGDPTG
  • PKTCENF
  • GDIKIEVFCE
  • GPNTNGSQ
  • ENFLALC
  • KYTVFGKVIDG
  • FMVQTGDP

Post-translational modifications for PPIL3 Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Domains & Families for PPIL3 Gene

Gene Families for PPIL3 Gene

Suggested Antigen Peptide Sequences for PPIL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2H8

UniProtKB/Swiss-Prot:

PPIL3_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
genes like me logo Genes that share domains with PPIL3: view

Function for PPIL3 Gene

Molecular function for PPIL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIL3 Gene

Gene Ontology (GO) - Molecular Function for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0005515 protein binding IPI 16189514
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL3: view
genes like me logo Genes that share phenotypes with PPIL3: view

Animal Models for PPIL3 Gene

MGI Knock Outs for PPIL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIL3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIL3 Gene

Localization for PPIL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL3 Gene COMPARTMENTS Subcellular localization image for PPIL3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL3 Gene

Pathways & Interactions for PPIL3 Gene

SuperPathways for PPIL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006397 mRNA processing IEA --
GO:0006457 protein folding IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL3 Gene

Transcripts for PPIL3 Gene

Unigene Clusters for PPIL3 Gene

Peptidylprolyl isomerase (cyclophilin)-like 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL3 Gene

No ASD Table

Relevant External Links for PPIL3 Gene

GeneLoc Exon Structure for
PPIL3
ECgene alternative splicing isoforms for
PPIL3

Expression for PPIL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIL3 Gene

This gene is overexpressed in Lavage (10.0), Nasal epithelium (8.9), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIL3 Gene



Protein tissue co-expression partners for PPIL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL3 Gene:

PPIL3

SOURCE GeneReport for Unigene cluster for PPIL3 Gene:

Hs.121076

mRNA Expression by UniProt/SwissProt for PPIL3 Gene:

Q9H2H8-PPIL3_HUMAN
Tissue specificity: Ubiquitous. Detected at low levels.
genes like me logo Genes that share expression patterns with PPIL3: view

Primer Products

No data available for mRNA differential expression in normal tissues for PPIL3 Gene

Orthologs for PPIL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL3 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia PPIL3 34
  • 94.41 (n)
-- 35
  • 84 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppil3 34 16 35
  • 93.37 (n)
cow
(Bos Taurus)
Mammalia PPIL3 34 35
  • 92.96 (n)
rat
(Rattus norvegicus)
Mammalia Ppil3 34
  • 92.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PPIL3 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL3 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL3 34 35
  • 81.46 (n)
lizard
(Anolis carolinensis)
Reptilia PPIL3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil3 34
  • 74.58 (n)
Str.17154 34
zebrafish
(Danio rerio)
Actinopterygii zgc:86715 34
  • 76.67 (n)
PPIL3 35
  • 70 (a)
OneToOne
Dr.16990 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3441 34
fruit fly
(Drosophila melanogaster)
Insecta CG11777 36 34 35
  • 67.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009996 34
  • 65.62 (n)
worm
(Caenorhabditis elegans)
Secernentea cyn-10 34 35
  • 65.62 (n)
cyp-10 36
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01940 34
  • 65.62 (n)
rice
(Oryza sativa)
Liliopsida Os06g0130500 34
  • 61.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10388 34
  • 57.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12592 34
Species where no ortholog for PPIL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL3 Gene

ENSEMBL:
Gene Tree for PPIL3 (if available)
TreeFam:
Gene Tree for PPIL3 (if available)

Paralogs for PPIL3 Gene

Paralogs for PPIL3 Gene

genes like me logo Genes that share paralogs with PPIL3: view

Variants for PPIL3 Gene

Sequence variations from dbSNP and Humsavar for PPIL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10204951 -- 200,888,628(+) tcaag(C/T)gattg intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10931927 -- 200,886,706(+) CAGGC(A/G)TGAGC intron-variant
rs111278610 -- 200,870,905(+) TGAGA(C/T)CCAAA downstream-variant-500B
rs111292412 -- 200,877,623(+) AGGCT(-/T)GGACT intron-variant
rs111315781 -- 200,874,001(+) GAGAT(A/T)GAGAC intron-variant

Variation tolerance for PPIL3 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPIL3 Gene

Disorders for PPIL3 Gene

Relevant External Links for PPIL3

Genetic Association Database (GAD)
PPIL3
Human Genome Epidemiology (HuGE) Navigator
PPIL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL3

No disorders were found for PPIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL3 Gene

Publications for PPIL3 Gene

  1. Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. (PMID: 11435694) Zhou Z. … Mao Y. (Cytogenet. Cell Genet. 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. (PMID: 18474220) Huo D.H. … Yang J. (Biochem. Biophys. Res. Commun. 2008) 3 22 64
  4. Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family. (PMID: 15735342) Huang L.-L. … Xia Z.-X. (Acta Crystallogr. D 2005) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for PPIL3 Gene

Sources for PPIL3 Gene

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