Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPIL2 Gene

Aliases for PPIL2 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 2 2 3
  • CYP60 3 4 6
  • U-Box Domain Containing 7 2 3
  • Rotamase PPIL2 3 4
  • Cyclophilin-60 3 4
  • EC 5.2.1.8 4 63
  • HCyP-60 3 4
  • PPIASE 3 4
  • CYC4 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 2 3
  • Peptidylprolyl Cis-Trans Isomerase 3
  • Cyclophilin-Like Protein CyP-60 3
  • Cyclophilin-Like Protein Cyp-60 4
  • Cyclophilin, 60kDa 3
  • EC 6.3.2.- 4
  • Cyp-60 3
  • UBOX7 3

External Ids for PPIL2 Gene

Previous GeneCards Identifiers for PPIL2 Gene

  • GC22P018719
  • GC22P020344
  • GC22P022006
  • GC22P004978

Summaries for PPIL2 Gene

Entrez Gene Summary for PPIL2 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL2 Gene

PPIL2 (Peptidylprolyl Isomerase (Cyclophilin)-Like 2) is a Protein Coding gene. Diseases associated with PPIL2 include hiv-1. Among its related pathways are Hemostasis and Cell surface interactions at the vascular wall. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL2 Gene

  • May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating Lys-48-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).

Gene Wiki entry for PPIL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL2 Gene

Genomics for PPIL2 Gene

Regulatory Elements for PPIL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIL2 Gene

Start:
21,652,270 bp from pter
End:
21,700,015 bp from pter
Size:
47,746 bases
Orientation:
Plus strand

Genomic View for PPIL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL2 Gene

Proteins for PPIL2 Gene

  • Protein details for PPIL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13356-PPIL2_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 2
    Protein Accession:
    Q13356
    Secondary Accessions:
    • Q13357
    • Q8TAH2
    • Q9BWR8

    Protein attributes for PPIL2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58823 Da
    Quaternary structure:
    • Interacts with BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.

    Three dimensional structures from OCA and Proteopedia for PPIL2 Gene

    Alternative splice isoforms for PPIL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL2 Gene

Proteomics data for PPIL2 Gene at MOPED

Selected DME Specific Peptides for PPIL2 Gene

Post-translational modifications for PPIL2 Gene

  • Ubiquitination at Lys82 and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL2 Gene

Domains for PPIL2 Gene

Gene Families for PPIL2 Gene

HGNC:
  • UBOX :U-box domain containing

Suggested Antigen Peptide Sequences for PPIL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13356

UniProtKB/Swiss-Prot:

PPIL2_HUMAN :
  • Q13356
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 U-box domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
genes like me logo Genes that share domains with PPIL2: view

Function for PPIL2 Gene

Molecular function for PPIL2 Gene

GENATLAS Biochemistry: peptidylprolyl isomerase (cyclophilin)-like 2
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating Lys-48-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).

Enzyme Numbers (IUBMB) for PPIL2 Gene

Gene Ontology (GO) - Molecular Function for PPIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 15946952
GO:0016874 ligase activity IEA --
GO:0034450 ubiquitin-ubiquitin ligase activity IDA 11435423
genes like me logo Genes that share ontologies with PPIL2: view

Phenotypes for PPIL2 Gene

GenomeRNAi human phenotypes for PPIL2:
genes like me logo Genes that share phenotypes with PPIL2: view

Animal Model Products

CRISPR Products

miRNA for PPIL2 Gene

miRTarBase miRNAs that target PPIL2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIL2 Gene

Localization for PPIL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIL2 Gene

Nucleus. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269 PubMed:15946952}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL2 Gene COMPARTMENTS Subcellular localization image for PPIL2 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8660300
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15946952
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IDA 15946952
genes like me logo Genes that share ontologies with PPIL2: view

Pathways for PPIL2 Gene

genes like me logo Genes that share pathways with PPIL2: view

Pathways by source for PPIL2 Gene

UniProtKB/Swiss-Prot Q13356-PPIL2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for PPIL2 Gene

Gene Ontology (GO) - Biological Process for PPIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 11435423
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
GO:0007596 blood coagulation TAS --
GO:0016567 protein ubiquitination --
genes like me logo Genes that share ontologies with PPIL2: view

Transcripts for PPIL2 Gene

Unigene Clusters for PPIL2 Gene

Peptidylprolyl isomerase (cyclophilin)-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a ·
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19b · 19c ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b · 22c
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: - - - - -
SP10: - - - - - -

Relevant External Links for PPIL2 Gene

GeneLoc Exon Structure for
PPIL2
ECgene alternative splicing isoforms for
PPIL2

Expression for PPIL2 Gene

mRNA expression in normal human tissues for PPIL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PPIL2 Gene

SOURCE GeneReport for Unigene cluster for PPIL2 Gene Hs.438587

mRNA Expression by UniProt/SwissProt for PPIL2 Gene

Q13356-PPIL2_HUMAN
Tissue specificity: Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.
genes like me logo Genes that share expressions with PPIL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIL2 Gene

Orthologs for PPIL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL2 35
  • 99.62 (n)
  • 99.81 (a)
PPIL2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPIL2 35
  • 87.56 (n)
  • 91.15 (a)
PPIL2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL2 35
  • 90.19 (n)
  • 92.88 (a)
PPIL2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil2 35
  • 85.83 (n)
  • 90.38 (a)
Ppil2 16
Ppil2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIL2 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil2 35
  • 86.35 (n)
  • 90.58 (a)
chicken
(Gallus gallus)
Aves PPIL2 35
  • 74.9 (n)
  • 83.4 (a)
PPIL2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL2 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53046 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil2 35
  • 71.91 (n)
  • 78.83 (a)
zebrafish
(Danio rerio)
Actinopterygii ppil2 35
  • 70.33 (n)
  • 75.53 (a)
ppil2 36
  • 72 (a)
OneToOne
zgc56616 35
fruit fly
(Drosophila melanogaster)
Insecta CG7747 35
  • 59.78 (n)
  • 54.78 (a)
CG7747 36
  • 52 (a)
OneToOne
CG7747 37
  • 53 (a)
CG11777 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-4 35
  • 53.03 (n)
  • 50.29 (a)
cyn-4 36
  • 47 (a)
OneToOne
cyp-10 37
  • 56 (a)
cyp-16 37
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 36
  • 33 (a)
ManyToMany
CPR5 36
  • 33 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PUB49 35
  • 51.84 (n)
  • 47.96 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10850 35
rice
(Oryza sativa)
Liliopsida Os.26947 35
Os03g0201100 35
  • 50.57 (n)
  • 48.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00181 35
  • 53.82 (n)
  • 45.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp8 35
  • 51.37 (n)
  • 45.88 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2038 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
Species with no ortholog for PPIL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL2 Gene

ENSEMBL:
Gene Tree for PPIL2 (if available)
TreeFam:
Gene Tree for PPIL2 (if available)

Paralogs for PPIL2 Gene

Paralogs for PPIL2 Gene

genes like me logo Genes that share paralogs with PPIL2: view

Variants for PPIL2 Gene

Sequence variations from dbSNP and Humsavar for PPIL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs108815 -- 21,671,187(+) GGGAC(A/G)TGGCA intron-variant
rs108816 -- 21,671,381(+) CACTA(C/T)CCAAG intron-variant
rs366026 -- 21,691,211(+) agtgc(A/C/G/T)gagat intron-variant
rs370039 -- 21,690,097(+) CACAG(A/G)GATGG intron-variant
rs372108 -- 21,689,307(+) CATGC(A/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv914458 CNV Loss 21882294
dgv4881n71 CNV Loss 21882294
dgv4882n71 CNV Loss 21882294
nsv510804 CNV Loss 20534489
nsv528344 CNV Loss 19592680

Relevant External Links for PPIL2 Gene

HapMap Linkage Disequilibrium report
PPIL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL2 Gene

Disorders for PPIL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PPIL2 Gene including...

Search for PPIL2 Gene in MalaCards »

Relevant External Links for PPIL2

Genetic Association Database (GAD)
PPIL2
Human Genome Epidemiology (HuGE) Navigator
PPIL2
genes like me logo Genes that share disorders with PPIL2: view

No data available for UniProtKB/Swiss-Prot for PPIL2 Gene

Publications for PPIL2 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  2. U box proteins as a new family of ubiquitin-protein ligases. (PMID: 11435423) Hatakeyama S. … Nakayama K.I. (J. Biol. Chem. 2001) 3 4
  3. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. (PMID: 15189447) Hatakeyama S. … Nakayama K.I. (Genes Cells 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPIL2 Gene

  • Addgene plasmids for PPIL2

Sources for PPIL2 Gene

Back to Top

Content