Aliases for PPIL2 Gene
External Ids for PPIL2 Gene
Previous GeneCards Identifiers for PPIL2 Gene
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for PPIL2 Gene
PPIL2 (Peptidylprolyl Isomerase Like 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Basigin interactions. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is PPWD1.
UniProtKB/Swiss-Prot for PPIL2 Gene
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating Lys-48-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).