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Aliases for PPIL2 Gene

Aliases for PPIL2 Gene

  • Peptidylprolyl Isomerase Like 2 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 2 2 3
  • U-Box Domain Containing 7 2 3
  • Rotamase PPIL2 3 4
  • Cyclophilin-60 3 4
  • EC 5.2.1.8 4 63
  • HCyP-60 3 4
  • PPIASE 3 4
  • CYP60 3 4
  • CYC4 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 2 2
  • Peptidylprolyl Cis-Trans Isomerase 3
  • Cyclophilin-Like Protein CyP-60 3
  • Cyclophilin-Like Protein Cyp-60 4
  • Cyclophilin, 60kDa 3
  • EC 6.3.2.- 4
  • Cyp-60 3
  • UBOX7 3

External Ids for PPIL2 Gene

Previous GeneCards Identifiers for PPIL2 Gene

  • GC22P018719
  • GC22P020344
  • GC22P022006
  • GC22P004978
  • GC22P021782
  • GC22P021818

Summaries for PPIL2 Gene

Entrez Gene Summary for PPIL2 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for PPIL2 Gene

PPIL2 (Peptidylprolyl Isomerase Like 2) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Platelet activation, signaling and aggregation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL2 Gene

  • May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating Lys-48-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).

Gene Wiki entry for PPIL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL2 Gene

Genomics for PPIL2 Gene

Regulatory Elements for PPIL2 Gene

Enhancers for PPIL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIL2 on UCSC Golden Path with GeneCards custom track

Promoters for PPIL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIL2 Gene

Chromosome:
22
Start:
21,652,270 bp from pter
End:
21,700,015 bp from pter
Size:
47,746 bases
Orientation:
Plus strand

Genomic View for PPIL2 Gene

Genes around PPIL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL2 Gene

Proteins for PPIL2 Gene

  • Protein details for PPIL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13356-PPIL2_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 2
    Protein Accession:
    Q13356
    Secondary Accessions:
    • Q13357
    • Q8TAH2
    • Q9BWR8

    Protein attributes for PPIL2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58823 Da
    Quaternary structure:
    • Interacts with BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.

    Three dimensional structures from OCA and Proteopedia for PPIL2 Gene

    Alternative splice isoforms for PPIL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL2 Gene

Proteomics data for PPIL2 Gene at MOPED

Selected DME Specific Peptides for PPIL2 Gene

Post-translational modifications for PPIL2 Gene

  • Ubiquitination at Lys 82 and Lys 166
  • Modification sites at PhosphoSitePlus

Domains & Families for PPIL2 Gene

Suggested Antigen Peptide Sequences for PPIL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13356

UniProtKB/Swiss-Prot:

PPIL2_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 U-box domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
genes like me logo Genes that share domains with PPIL2: view

Function for PPIL2 Gene

Molecular function for PPIL2 Gene

GENATLAS Biochemistry:
peptidylprolyl isomerase (cyclophilin)-like 2
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating Lys-48-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).

Enzyme Numbers (IUBMB) for PPIL2 Gene

Gene Ontology (GO) - Molecular Function for PPIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 15946952
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with PPIL2: view

Phenotypes for PPIL2 Gene

genes like me logo Genes that share phenotypes with PPIL2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL2 Gene

Localization for PPIL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIL2 Gene

Nucleus. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269 PubMed:15946952}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL2 Gene COMPARTMENTS Subcellular localization image for PPIL2 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PPIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15946952
genes like me logo Genes that share ontologies with PPIL2: view

Pathways & Interactions for PPIL2 Gene

genes like me logo Genes that share pathways with PPIL2: view

Pathways by source for PPIL2 Gene

UniProtKB/Swiss-Prot Q13356-PPIL2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for PPIL2 Gene

Gene Ontology (GO) - Biological Process for PPIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0050900 leukocyte migration TAS --
GO:0072659 protein localization to plasma membrane IMP 15946952
genes like me logo Genes that share ontologies with PPIL2: view

No data available for SIGNOR curated interactions for PPIL2 Gene

Drugs & Compounds for PPIL2 Gene

No Compound Related Data Available

Transcripts for PPIL2 Gene

Unigene Clusters for PPIL2 Gene

Peptidylprolyl isomerase (cyclophilin)-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a ·
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19b · 19c ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b · 22c
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: - - - - -
SP10: - - - - - -

Relevant External Links for PPIL2 Gene

GeneLoc Exon Structure for
PPIL2
ECgene alternative splicing isoforms for
PPIL2

Expression for PPIL2 Gene

mRNA expression in normal human tissues for PPIL2 Gene

Protein differential expression in normal tissues from HIPED for PPIL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.7) and CD8 Tcells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PPIL2 Gene



SOURCE GeneReport for Unigene cluster for PPIL2 Gene Hs.438587

mRNA Expression by UniProt/SwissProt for PPIL2 Gene

Q13356-PPIL2_HUMAN
Tissue specificity: Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.
genes like me logo Genes that share expression patterns with PPIL2: view

Protein tissue co-expression partners for PPIL2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIL2 Gene

Orthologs for PPIL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIL2 35
  • 87.56 (n)
  • 91.15 (a)
PPIL2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL2 35
  • 90.19 (n)
  • 92.88 (a)
PPIL2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil2 35
  • 85.83 (n)
  • 90.38 (a)
Ppil2 16
Ppil2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIL2 35
  • 99.62 (n)
  • 99.81 (a)
PPIL2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil2 35
  • 86.35 (n)
  • 90.58 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIL2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL2 35
  • 74.9 (n)
  • 83.4 (a)
PPIL2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil2 35
  • 71.91 (n)
  • 78.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53046 35
zebrafish
(Danio rerio)
Actinopterygii ppil2 35
  • 70.33 (n)
  • 75.53 (a)
zgc56616 35
ppil2 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11777 37
  • 50 (a)
CG7747 37
  • 53 (a)
CG7747 35
  • 59.78 (n)
  • 54.78 (a)
CG7747 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cyp-10 37
  • 56 (a)
cyp-16 37
  • 46 (a)
cyn-4 35
  • 53.03 (n)
  • 50.29 (a)
cyn-4 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 36
  • 33 (a)
ManyToMany
CPR5 36
  • 33 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PUB49 35
  • 51.84 (n)
  • 47.96 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10850 35
rice
(Oryza sativa)
Liliopsida Os.26947 35
Os03g0201100 35
  • 50.57 (n)
  • 48.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2038 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00181 35
  • 53.82 (n)
  • 45.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp8 35
  • 51.37 (n)
  • 45.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
Species with no ortholog for PPIL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL2 Gene

ENSEMBL:
Gene Tree for PPIL2 (if available)
TreeFam:
Gene Tree for PPIL2 (if available)

Paralogs for PPIL2 Gene

Paralogs for PPIL2 Gene

genes like me logo Genes that share paralogs with PPIL2: view

Variants for PPIL2 Gene

Sequence variations from dbSNP and Humsavar for PPIL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs108815 -- 21,671,187(+) GGGAC(A/G)TGGCA intron-variant
rs108816 -- 21,671,381(+) CACTA(C/T)CCAAG intron-variant
rs2247115 -- 21,669,861(+) GACTT(C/T)GTCCT intron-variant
rs2278118 -- 21,688,629(+) CCAGG(C/T)TGGGC intron-variant
rs2298430 -- 21,669,653(+) CACCA(C/T)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv914458 CNV Loss 21882294
dgv4881n71 CNV Loss 21882294
dgv4882n71 CNV Loss 21882294
nsv510804 CNV Loss 20534489
nsv528344 CNV Loss 19592680

Variation tolerance for PPIL2 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPIL2 Gene

Disorders for PPIL2 Gene

Relevant External Links for PPIL2

Genetic Association Database (GAD)
PPIL2
Human Genome Epidemiology (HuGE) Navigator
PPIL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL2

No disorders were found for PPIL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL2 Gene

Publications for PPIL2 Gene

  1. Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population. (PMID: 19669607) Carson R. … Johnston J.A. (Neuromolecular Med. 2009) 3 48 67
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PPIL2 Gene

Sources for PPIL2 Gene

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