Aliases for PPIL2 Gene
External Ids for PPIL2 Gene
Previous GeneCards Identifiers for PPIL2 Gene
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPIL2 Gene
PPIL2 (Peptidylprolyl Isomerase (Cyclophilin)-Like 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Cell surface interactions at the vascular wall. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is PPIB.
UniProtKB/Swiss-Prot for PPIL2 Gene
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating Lys-48-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).