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Aliases for PPIL1 Gene

Aliases for PPIL1 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 1 2 3
  • CYPL1 3 4 6
  • Rotamase PPIL1 3 4
  • EC 4 63
  • PPIASE 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 3
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Cyclophilin-Related Gene 1 3
  • CGI-124 3
  • HCyPX 3

External Ids for PPIL1 Gene

Previous GeneCards Identifiers for PPIL1 Gene

  • GC06M036824
  • GC06M036869
  • GC06M036930
  • GC06M036540

Summaries for PPIL1 Gene

Entrez Gene Summary for PPIL1 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL1 Gene

PPIL1 (Peptidylprolyl Isomerase (Cyclophilin)-Like 1) is a Protein Coding gene. Diseases associated with PPIL1 include hiv-1. Among its related pathways are Spliceosome. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL1 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL1 Gene

Genomics for PPIL1 Gene

Regulatory Elements for PPIL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIL1 Gene

36,854,827 bp from pter
36,875,024 bp from pter
20,198 bases
Minus strand

Genomic View for PPIL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL1 Gene

Proteins for PPIL1 Gene

  • Protein details for PPIL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 1
    Protein Accession:
    Secondary Accessions:
    • O15001
    • Q5TDC9

    Protein attributes for PPIL1 Gene

    166 amino acids
    Molecular mass:
    18237 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with SNW1.

    Three dimensional structures from OCA and Proteopedia for PPIL1 Gene

neXtProt entry for PPIL1 Gene

Proteomics data for PPIL1 Gene at MOPED

Selected DME Specific Peptides for PPIL1 Gene

Post-translational modifications for PPIL1 Gene

  • Ubiquitination at Lys58 and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PPIL1 Gene

Suggested Antigen Peptide Sequences for PPIL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y3C6
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
genes like me logo Genes that share domains with PPIL1: view

No data available for Gene Families for PPIL1 Gene

Function for PPIL1 Gene

Molecular function for PPIL1 Gene

GENATLAS Biochemistry:
peptidylprolyl isomerase (cyclophilin)-like 1,cellular target of cyclosporin A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide {ECO:0000269 PubMed:16595688};
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Cyclosporin A.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIL1 Gene

Gene Ontology (GO) - Molecular Function for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16595688
genes like me logo Genes that share ontologies with PPIL1: view

Phenotypes for PPIL1 Gene

GenomeRNAi human phenotypes for PPIL1:
genes like me logo Genes that share phenotypes with PPIL1: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIL1 Gene

Localization for PPIL1 Gene

Subcellular locations from

Jensen Localization Image for PPIL1 Gene COMPARTMENTS Subcellular localization image for PPIL1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL1 Gene

Pathways for PPIL1 Gene

SuperPathways for PPIL1 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with PPIL1: view

Pathways by source for PPIL1 Gene

1 KEGG pathway for PPIL1 Gene

Gene Ontology (GO) - Biological Process for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIL1: view

Transcripts for PPIL1 Gene

mRNA/cDNA for PPIL1 Gene

(311) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIL1 Gene

Peptidylprolyl isomerase (cyclophilin)-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -

Relevant External Links for PPIL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL1 Gene

mRNA expression in normal human tissues for PPIL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL1 Gene

SOURCE GeneReport for Unigene cluster for PPIL1 Gene Hs.27693

mRNA Expression by UniProt/SwissProt for PPIL1 Gene

Tissue specificity: Ubiquitous, with the most abundant expression in heart and skeletal muscle
genes like me logo Genes that share expressions with PPIL1: view

Expression partners for PPIL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PPIL1 Gene

Orthologs for PPIL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPIL1 35
  • 92.37 (n)
  • 100 (a)
PPIL1 36
  • 100 (a)
(Canis familiaris)
Mammalia PPIL1 35
  • 92.57 (n)
  • 100 (a)
PPIL1 36
  • 100 (a)
(Mus musculus)
Mammalia Ppil1 35
  • 88.15 (n)
  • 98.19 (a)
Ppil1 16
Ppil1 36
  • 98 (a)
(Pan troglodytes)
Mammalia PPIL1 35
  • 100 (n)
  • 100 (a)
PPIL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppil1 35
  • 88.15 (n)
  • 98.8 (a)
(Monodelphis domestica)
Mammalia PPIL1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia PPIL1 36
  • 95 (a)
(Gallus gallus)
Aves LOC100859332 35
  • 73.29 (n)
  • 83.13 (a)
PPIL1 36
  • 84 (a)
(Anolis carolinensis)
Reptilia PPIL1 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil1 35
  • 73.69 (n)
  • 83.13 (a)
Str.6409 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398596 35
(Danio rerio)
Actinopterygii ppil1 35
  • 77.37 (n)
  • 87.04 (a)
wufe11h12 35
ppil1 36
  • 85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12744 35
fruit fly
(Drosophila melanogaster)
Insecta Cypl 37
  • 76 (a)
Cypl 35
  • 67.09 (n)
  • 76.1 (a)
Cypl 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012376 35
  • 64.39 (n)
  • 70.81 (a)
(Caenorhabditis elegans)
Secernentea cyp-12 37
  • 68 (a)
cyp-16 37
  • 52 (a)
cyn-12 35
  • 61.67 (n)
  • 68.13 (a)
cyn-12 36
  • 65 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36130 35
  • 62.08 (n)
  • 65 (a)
(Hordeum vulgare)
Liliopsida Hv.10736 35
(Oryza sativa)
Liliopsida Os.5480 35
Os08g0559400 35
  • 65.34 (n)
  • 68.87 (a)
(Triticum aestivum)
Liliopsida Ta.22715 35
(Zea mays)
Liliopsida Zm.13687 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14063 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00578 35
  • 65.11 (n)
  • 73.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp1 35
  • 63.33 (n)
  • 67.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
Species with no ortholog for PPIL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIL1 Gene

Gene Tree for PPIL1 (if available)
Gene Tree for PPIL1 (if available)

Paralogs for PPIL1 Gene

Paralogs for PPIL1 Gene

Selected SIMAP similar genes for PPIL1 Gene using alignment to 1 proteins: Pseudogenes for PPIL1 Gene

genes like me logo Genes that share paralogs with PPIL1: view

Variants for PPIL1 Gene

Sequence variations from dbSNP and Humsavar for PPIL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs236346 -- 36,864,327(-) agcag(A/G)gtgcc intron-variant
rs236347 -- 36,862,479(-) cttga(C/T)tcagc intron-variant
rs236348 -- 36,859,121(-) GACCT(A/G)TTCCT intron-variant
rs553756 -- 36,860,013(-) catct(C/T)tacta intron-variant
rs864953 -- 36,860,209(-) gatta(C/T)aggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL1 Gene

Variant ID Type Subtype PubMed ID
nsv5262 CNV Loss 18451855

Relevant External Links for PPIL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL1 Gene

Disorders for PPIL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPIL1 Gene in MalaCards »

(1) Diseases for PPIL1 Gene including...

genes like me logo Genes that share disorders with PPIL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PPIL1 Gene

Publications for PPIL1 Gene

  1. Cloning, expression and chromosomal mapping of a novel cyclophilin- related gene (PPIL1) from human fetal brain. (PMID: 8978786) Ozaki K. … Shin S. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PMID: 10072585) Mann S.S. … Hart T.C. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PMID: 16595688) Xu C. … Zhang Q. (J. Biol. Chem. 2006) 3 4 23
  4. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PMID: 20368803) Stegmann C.M. … Wahl M.C. (PLoS ONE 2010) 3 4 23
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4

Products for PPIL1 Gene

Sources for PPIL1 Gene

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