Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPIL1 Gene

Aliases for PPIL1 Gene

  • Peptidylprolyl Isomerase Like 1 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 1 2 3
  • Cyclophilin Like 1 2 3
  • Rotamase PPIL1 3 4
  • EC 5.2.1.8 4 63
  • PPIASE 3 4
  • CYPL1 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Cyclophilin-Related Gene 1 3
  • CGI-124 3
  • HCyPX 3

External Ids for PPIL1 Gene

Previous GeneCards Identifiers for PPIL1 Gene

  • GC06M036824
  • GC06M036869
  • GC06M036930
  • GC06M036540

Summaries for PPIL1 Gene

Entrez Gene Summary for PPIL1 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL1 Gene

PPIL1 (Peptidylprolyl Isomerase Like 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL1 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL1 Gene

Genomics for PPIL1 Gene

Regulatory Elements for PPIL1 Gene

Promoters for PPIL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIL1 Gene

Chromosome:
6
Start:
36,854,827 bp from pter
End:
36,875,024 bp from pter
Size:
20,198 bases
Orientation:
Minus strand

Genomic View for PPIL1 Gene

Genes around PPIL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL1 Gene

Proteins for PPIL1 Gene

  • Protein details for PPIL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C6-PPIL1_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 1
    Protein Accession:
    Q9Y3C6
    Secondary Accessions:
    • O15001
    • Q5TDC9

    Protein attributes for PPIL1 Gene

    Size:
    166 amino acids
    Molecular mass:
    18237 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with SNW1.

    Three dimensional structures from OCA and Proteopedia for PPIL1 Gene

neXtProt entry for PPIL1 Gene

Proteomics data for PPIL1 Gene at MOPED

Selected DME Specific Peptides for PPIL1 Gene

Post-translational modifications for PPIL1 Gene

  • Ubiquitination at Lys 58 and Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PPIL1 Gene

Gene Families for PPIL1 Gene

Suggested Antigen Peptide Sequences for PPIL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C6

UniProtKB/Swiss-Prot:

PPIL1_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
genes like me logo Genes that share domains with PPIL1: view

Function for PPIL1 Gene

Molecular function for PPIL1 Gene

GENATLAS Biochemistry:
peptidylprolyl isomerase (cyclophilin)-like 1,cellular target of cyclosporin A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide {ECO:0000269 PubMed:16595688};
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Cyclosporin A.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIL1 Gene

genes like me logo Genes that share phenotypes with PPIL1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL1 Gene

Localization for PPIL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL1 Gene COMPARTMENTS Subcellular localization image for PPIL1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PPIL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL1 Gene

Pathways & Interactions for PPIL1 Gene

SuperPathways for PPIL1 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with PPIL1: view

Pathways by source for PPIL1 Gene

1 KEGG pathway for PPIL1 Gene

Gene Ontology (GO) - Biological Process for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIL1: view

No data available for SIGNOR curated interactions for PPIL1 Gene

Drugs & Compounds for PPIL1 Gene

No Compound Related Data Available

Transcripts for PPIL1 Gene

mRNA/cDNA for PPIL1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(311) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIL1 Gene

Peptidylprolyl isomerase (cyclophilin)-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -

Relevant External Links for PPIL1 Gene

GeneLoc Exon Structure for
PPIL1
ECgene alternative splicing isoforms for
PPIL1

Expression for PPIL1 Gene

mRNA expression in normal human tissues for PPIL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL1 Gene



SOURCE GeneReport for Unigene cluster for PPIL1 Gene Hs.27693

mRNA Expression by UniProt/SwissProt for PPIL1 Gene

Q9Y3C6-PPIL1_HUMAN
Tissue specificity: Ubiquitous, with the most abundant expression in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with PPIL1: view

Protein tissue co-expression partners for PPIL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PPIL1 Gene

Orthologs for PPIL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIL1 35
  • 92.37 (n)
  • 100 (a)
PPIL1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL1 35
  • 92.57 (n)
  • 100 (a)
PPIL1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil1 35
  • 88.15 (n)
  • 98.19 (a)
Ppil1 16
Ppil1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIL1 35
  • 100 (n)
  • 100 (a)
PPIL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil1 35
  • 88.15 (n)
  • 98.8 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIL1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859332 35
  • 73.29 (n)
  • 83.13 (a)
PPIL1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil1 35
  • 73.69 (n)
  • 83.13 (a)
Str.6409 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398596 35
zebrafish
(Danio rerio)
Actinopterygii ppil1 35
  • 77.37 (n)
  • 87.04 (a)
wufe11h12 35
ppil1 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12744 35
fruit fly
(Drosophila melanogaster)
Insecta Cypl 37
  • 76 (a)
Cypl 35
  • 67.09 (n)
  • 76.1 (a)
Cypl 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012376 35
  • 64.39 (n)
  • 70.81 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-12 37
  • 68 (a)
cyp-16 37
  • 52 (a)
cyn-12 35
  • 61.67 (n)
  • 68.13 (a)
cyn-12 36
  • 65 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36130 35
  • 62.08 (n)
  • 65 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10736 35
rice
(Oryza sativa)
Liliopsida Os.5480 35
Os08g0559400 35
  • 65.34 (n)
  • 68.87 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22715 35
corn
(Zea mays)
Liliopsida Zm.13687 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14063 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00578 35
  • 65.11 (n)
  • 73.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp1 35
  • 63.33 (n)
  • 67.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for PPIL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIL1 Gene

ENSEMBL:
Gene Tree for PPIL1 (if available)
TreeFam:
Gene Tree for PPIL1 (if available)

Paralogs for PPIL1 Gene

Paralogs for PPIL1 Gene

(22) SIMAP similar genes for PPIL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PPIL1 Gene

genes like me logo Genes that share paralogs with PPIL1: view

Variants for PPIL1 Gene

Sequence variations from dbSNP and Humsavar for PPIL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_051772 -
rs236346 -- 36,864,327(-) agcag(A/G)gtgcc intron-variant
rs236347 -- 36,862,479(-) cttga(C/T)tcagc intron-variant
rs236348 -- 36,859,121(-) GACCT(A/G)TTCCT intron-variant
rs553756 -- 36,860,013(-) catct(C/T)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL1 Gene

Variant ID Type Subtype PubMed ID
nsv5262 CNV Loss 18451855

Variation tolerance for PPIL1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIL1 Gene

HapMap Linkage Disequilibrium report
PPIL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL1 Gene

Disorders for PPIL1 Gene

Relevant External Links for PPIL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIL1

No disorders were found for PPIL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL1 Gene

Publications for PPIL1 Gene

  1. Cloning, expression and chromosomal mapping of a novel cyclophilin- related gene (PPIL1) from human fetal brain. (PMID: 8978786) Ozaki K. … Shin S. (Cytogenet. Cell Genet. 1996) 2 3 4 23 67
  2. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PMID: 10072585) Mann S.S. … Hart T.C. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. A large intrinsically disordered region in SKIP and its disorder- order transition induced by PPIL1 binding revealed by NMR. (PMID: 20007319) Wang X. … Shi Y. (J. Biol. Chem. 2010) 3 23
  4. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PMID: 20368803) Stegmann C.M. … Wahl M.C. (PLoS ONE 2010) 3 23
  5. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PMID: 16595688) Xu C. … Zhang Q. (J. Biol. Chem. 2006) 3 23

Products for PPIL1 Gene

Sources for PPIL1 Gene

Back to Top

Content