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Aliases for PPIL1 Gene

Aliases for PPIL1 Gene

  • Peptidylprolyl Isomerase (Cyclophilin)-Like 1 2 3
  • CYPL1 3 4 6
  • Rotamase PPIL1 3 4
  • EC 5.2.1.8 4 64
  • PPIASE 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 3
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Cyclophilin-Related Gene 1 3
  • CGI-124 3
  • HCyPX 3

External Ids for PPIL1 Gene

Summaries for PPIL1 Gene

Entrez Gene Summary for PPIL1 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL1 Gene

PPIL1 (Peptidylprolyl Isomerase (Cyclophilin)-Like 1) is a Protein Coding gene. Diseases associated with PPIL1 include hiv-1. Among its related pathways are Spliceosome. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIL1 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL1 Gene

Genomics for PPIL1 Gene

Genomic Location for PPIL1 Gene

Start:
36,854,827 bp from pter
End:
36,875,024 bp from pter
Size:
20,198 bases
Orientation:
Minus strand

Genomic View for PPIL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL1 Gene

Regulatory Elements for PPIL1 Gene

Proteins for PPIL1 Gene

  • Protein details for PPIL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C6-PPIL1_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 1
    Protein Accession:
    Q9Y3C6
    Secondary Accessions:
    • O15001
    • Q5TDC9

    Protein attributes for PPIL1 Gene

    Size:
    166 amino acids
    Molecular mass:
    18237 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with SNW1.

    Three dimensional structures from OCA and Proteopedia for PPIL1 Gene

neXtProt entry for PPIL1 Gene

Proteomics data for PPIL1 Gene at MOPED

Selected DME Specific Peptides for PPIL1 Gene

Post-translational modifications for PPIL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58 and Lys80

Other Protein References for PPIL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PPIL1 Gene

UniProtKB/Swiss-Prot:

PPIL1_HUMAN
Domain:
  • Contains 1 PPIase cyclophilin-type domain.:
    • Q9Y3C6
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.:
    • Q9Y3C6
genes like me logo Genes that share domains with PPIL1: view

No data available for Gene Families for PPIL1 Gene

Function for PPIL1 Gene

Molecular function for PPIL1 Gene

GENATLAS Biochemistry: peptidylprolyl isomerase (cyclophilin)-like 1,cellular target of cyclosporin A
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide {ECO:0000269 PubMed:16595688};
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by Cyclosporin A.
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIL1 Gene

Gene Ontology (GO) - Molecular Function for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16595688
genes like me logo Genes that share ontologies with PPIL1: view

Phenotypes for PPIL1 Gene

GenomeRNAi human phenotypes for PPIL1:
genes like me logo Genes that share phenotypes with PPIL1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIL1 Gene

Localization for PPIL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIL1 Gene COMPARTMENTS Subcellular localization image for PPIL1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL1: view

Pathways for PPIL1 Gene

SuperPathways for PPIL1 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with PPIL1: view

Pathways by source for PPIL1 Gene

1 KEGG pathway for PPIL1 Gene

Gene Ontology (GO) - Biological Process for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIL1: view

Transcripts for PPIL1 Gene

mRNA/cDNA for PPIL1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(311) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIL1 Gene

Peptidylprolyl isomerase (cyclophilin)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -

Relevant External Links for PPIL1 Gene

GeneLoc Exon Structure for
PPIL1
ECgene alternative splicing isoforms for
PPIL1

Expression for PPIL1 Gene

mRNA expression in normal human tissues for PPIL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIL1 Gene

SOURCE GeneReport for Unigene cluster for PPIL1 Gene Hs.27693

mRNA Expression by UniProt/SwissProt for PPIL1 Gene

Q9Y3C6-PPIL1_HUMAN
Tissue specificity: Ubiquitous, with the most abundant expression in heart and skeletal muscle
genes like me logo Genes that share expressions with PPIL1: view

Orthologs for PPIL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL1 36
  • 100 (n)
  • 100 (a)
PPIL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPIL1 36
  • 92.37 (n)
  • 100 (a)
PPIL1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL1 36
  • 92.57 (n)
  • 100 (a)
PPIL1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppil1 36
  • 88.15 (n)
  • 98.19 (a)
Ppil1 16
Ppil1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIL1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL1 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil1 36
  • 88.15 (n)
  • 98.8 (a)
chicken
(Gallus gallus)
Aves LOC100859332 36
  • 73.29 (n)
  • 83.13 (a)
PPIL1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL1 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398596 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil1 36
  • 73.69 (n)
  • 83.13 (a)
Str.6409 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12744 36
zebrafish
(Danio rerio)
Actinopterygii ppil1 36
  • 77.37 (n)
  • 87.04 (a)
ppil1 37
  • 85 (a)
OneToOne
wufe11h12 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012376 36
  • 64.39 (n)
  • 70.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cypl 36
  • 67.09 (n)
  • 76.1 (a)
Cypl 37
  • 69 (a)
OneToOne
Cypl 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-12 36
  • 61.67 (n)
  • 68.13 (a)
cyn-12 37
  • 65 (a)
OneToOne
cyp-16 38
  • 52 (a)
cyp-12 38
  • 68 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36130 36
  • 62.08 (n)
  • 65 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10736 36
corn
(Zea mays)
Liliopsida Zm.13687 36
rice
(Oryza sativa)
Liliopsida Os.5480 36
Os08g0559400 36
  • 65.34 (n)
  • 68.87 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22715 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00578 36
  • 65.11 (n)
  • 73.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp1 36
  • 63.33 (n)
  • 67.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14063 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 67 (a)
OneToOne
Species with no ortholog for PPIL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIL1 Gene

ENSEMBL:
Gene Tree for PPIL1 (if available)
TreeFam:
Gene Tree for PPIL1 (if available)

Paralogs for PPIL1 Gene

Paralogs for PPIL1 Gene

Selected SIMAP similar genes for PPIL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PPIL1 Gene

genes like me logo Genes that share paralogs with PPIL1: view

Variants for PPIL1 Gene

Sequence variations from dbSNP and Humsavar for PPIL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs236346 -- 36,864,327(-) agcag(A/G)gtgcc intron-variant
rs236347 -- 36,862,479(-) cttga(C/T)tcagc intron-variant
rs236348 -- 36,859,121(-) GACCT(A/G)TTCCT intron-variant
rs553756 -- 36,860,013(-) catct(C/T)tacta intron-variant
rs864953 -- 36,860,209(-) gatta(C/T)aggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL1 Gene

Variant ID Type Subtype PubMed ID
nsv5262 CNV Loss 18451855

Relevant External Links for PPIL1 Gene

HapMap Linkage Disequilibrium report
PPIL1

Disorders for PPIL1 Gene

(1) MalaCards Diseases for PPIL1 Gene

Search for PPIL1 Gene in MalaCards »
genes like me logo Genes that share disorders with PPIL1: view

No data available for UniProtKB/Swiss-Prot for PPIL1 Gene

Publications for PPIL1 Gene

  1. Cloning, expression and chromosomal mapping of a novel cyclophilin- related gene (PPIL1) from human fetal brain. (PMID: 8978786) Ozaki K. … Shin S. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PMID: 10072585) Mann S.S. … Hart T.C. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PMID: 16595688) Xu C. … Zhang Q. (J. Biol. Chem. 2006) 3 4 23
  4. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PMID: 20368803) Stegmann C.M. … Wahl M.C. (PLoS ONE 2010) 3 4 23
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4

Products for PPIL1 Gene

Sources for PPIL1 Gene

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