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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPIL1 Gene

protein-coding GIFtS: 59
GCID: GC06M036869

peptidylprolyl isomerase (cyclophilin)-like 1

Explore 2 diseases affiliated with
PPIL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase (Cyclophilin)-Like 1¹ ²		Cyclophilin-Related Gene 1²
CYPL1¹ ² ³ ⁵		HCyPX¹
Rotamase PPIL1² ³		Peptidyl-Prolyl Cis-Trans Isomerase²
PPIase² ³		Peptidyl-Prolyl Cis-Trans Isomerase-Like 1²
EC 5.2.1.8³ ⁸

External Ids:	HGNC: 9260¹	Entrez Gene: 51645²	Ensembl: ENSG00000137168⁷	OMIM: 601301⁵	UniProtKB: Q9Y3C6³

Export aliases for PPIL1 gene to outside databases

Previous GC identifers: GC06M036824 GC06M036930 GC06M036540

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIL1:

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly

conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by

cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the

folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

Gene Wiki entry for PPIL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPIL1 gene promoter:
TBP NCX/Ncx AP-2gamma Ik-3 c-Ets-1 Pax-3 TFIID AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPIL1 promoter sequence

Search SABiosciences Chromatin IP Primers for PPIL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.1

PPIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIL1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M036869: view genomic region (about GC identifiers)

Start:	36,822,603 bp from pter	End:	36,842,800 bp from pter
Size:	20,198 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase-like 1

Size: 166 amino acids; 18237 Da

Subunit: Identified in the spliceosome C complex. Interacts with SNW1

3 PDB 3D structures from and Proteopedia for PPIL1:

1XWN (3D)

2K7N (3D)

2X7K (3D)

Secondary accessions: O15001 Q5TDC9

Explore the universe of human proteins at neXtProt for PPIL1: NX_Q9Y3C6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y3C6

4/6 DME Specific Peptides for PPIL1 (Q9Y3C6) (see all 6)

FMIQGGD

GDPTGTG

TNGSQFF

KHTIFGRV

PPIL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057143.1

ENSEMBL proteins:

ENSP00000362803

Human Recombinant Protein Products for PPIL1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PPIL1
	Uscn Proteins for PPIL1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0071013	catalytic step 2 spliceosome	IDA	11991638

PPIL1 for ontologies About GeneDecksing

PPIL1 Antibody Products:

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	Uscn ELISAs and CLIAs for PPIL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPIL1 for domains About GeneDecksing

3 InterPro domains/families:

IPR002130 Cyclophilin-like_PPIase_dom

IPR024936 Cyclophilin-type_PPIase

IPR020892 Cyclophilin-type_PPIase_CS

Graphical View of Domain Structure for InterPro Entry Q9Y3C6

ProtoNet protein and cluster: Q9Y3C6

1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6

Similarity: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily

Similarity: Contains 1 PPIase cyclophilin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PPIL1_HUMAN, Q9Y3C6

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme regulation: Inhibited by Cyclosporin A

Biophysicochemical properties: Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide;

Genatlas biochemistry entry for PPIL1:

peptidylprolyl isomerase (cyclophilin)-like 1,cellular target of cyclosporin A

Enzyme Number (IUBMB): EC 5.2.1.8¹ ²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA	--
GO:0005515	protein binding	IPI	--

PPIL1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PPIL1:

Synthetic lethal with Ras

1 MGI phenotypic allele

for Ppil1 (no phenotypes)

PPIL1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PPIL1

miRNA Products:		OriGene 3'-UTR Clone: PPIL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIL1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIL1 (see all 16):
		hsa-miR-579 hsa-miR-4286 hsa-miR-1271 hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-3148 hsa-miR-514b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: PPIL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIL1 (see all 7) OriGene shRNA RFP: PPIL1 OriGene siRNA: PPIL1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PPIL1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PPIL1
			Sirion Biotech Customized adenovirus for overexpression of PPIL1 Sirion Biotech Customized adenovirus for potent knockdown of PPIL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PPIL1 (NM_016059)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPIL1
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		Sirion Biotech Customized stable knockdown cell line services for PPIL1 Sirion Biotech Customized inducible knockdown cell line services for PPIL1 Sirion Biotech Customized stable overexpressing cell line services for PPIL1 Sirion Biotech Customized inducible overexpressing cell line services for PPIL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

Spliceosome

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for PPIL1):

Spliceosome

PPIL1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPIL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/16 Interacting proteins for PPIL1 (Q9Y3C6^{1, 2, 3} ENSP00000362803⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNW1	Q13573¹^,³, ENSP00000261531⁴	EBI-2557649,EBI-632715 I2D: score=1 STRING: ENSP00000261531
WDR83	Q9BRX9², ENSP00000242796⁴	MINT-8332097 MINT-8337189 STRING: ENSP00000242796
SRRM1	Q8IYB3³, ENSP00000326261⁴	I2D: score=1 STRING: ENSP00000326261
SRRM2	Q9UQ35³, ENSP00000301740⁴	I2D: score=1 STRING: ENSP00000301740
RBM42	Q9BTD8², ENSP00000262633⁴	MINT-8337244 STRING: ENSP00000262633

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	IC	11991638
GO:0006457	protein folding	IEA	--

PPIL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPIL1
Search CenterWatch for drugs/clinical trials and news about PPIL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPIL1 gene:

NM_016059.4

Unigene Cluster for PPIL1:

Peptidylprolyl isomerase (cyclophilin)-like 1

Hs.27693 [show with all ESTs]

Unigene Representative Sequence: NM_016059

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373699(uc003omu.2) ENST00000483552

miRNA Products:		OriGene 3'-UTR Clone: PPIL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIL1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIL1 (see all 16):
		hsa-miR-579 hsa-miR-4286 hsa-miR-1271 hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-3148 hsa-miR-514b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: PPIL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIL1 (see all 7) OriGene shRNA RFP: PPIL1 OriGene siRNA: PPIL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIL1
		Sirion Biotech Custom design and validation of potent shRNA sequences against PPIL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PPIL1 (NM_016059)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIL1

Additional cDNA sequence:

AF151882.1 AK026636.1 AY359032.1 BC003048.1

10 DOTS entries:

DT.116269 DT.95335508 DT.121337716 DT.100794526 DT.121337704 DT.121337732 DT.95171943 DT.318017

DT.40298481 DT.70101771

24/311 AceView cDNA sequences (see all 311):

BF002320 CA942162 BM703477 AW573248 T07826 BQ012408 BF110487 CD364396

AI628790 CR590493 BF732339 AI420382 AW015641 BU688914 NM_016059 AA913439

AW002644 BF196840 AI824956 BQ899063 BQ226329 BF593322 Z41687 BM764189

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIL1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c
SP1:							-
SP2:							-		-
SP3:									-

ECgene alternative splicing isoforms for PPIL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPIL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCCTCCTT

About this image

PPIL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Kidney

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PPIL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIL1

SOURCE GeneReport for Unigene cluster: Hs.27693

UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6

Tissue specificity: Ubiquitous, with the most abundant expression in heart and skeletal muscle

SABiosciences Custom PCR Arrays for PPIL1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for PPIL1 gene from 9/41 species (see all 41) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100859332¹	peptidyl-prolyl cis-trans isomerase-like 1-like	73.24(n) 84.35(a)		100859332 XM_003643916.1 XP_003643964.1
lizard (Anolis carolinensis)	Reptilia	PPIL1⁶	--	88(a)	1 ↔ 1	4(125098538-125101726)
African clawed frog (Xenopus laevis)	Amphibia	LOC398596²	similar to peptidylprolyl isomerase (cyclophilin)-like more	74.98(n)		BC051602.1
zebrafish (Danio rerio)	Actinopterygii	wufe11h12²	Transcribed sequence with moderate similarity to protein more	79.13(n)		BM072075.1
fruit fly (Drosophila melanogaster)	Insecta	Cypl^{1 , 3}	peptidyl-prolyl cis-trans isomerase³ Cyclophilin-like¹	76(a)³ 67.09(n)¹ 76.1(a)¹		61C3³ 38069¹ NM_079150.3¹ NP_523874.1¹
worm (Caenorhabditis elegans)	Secernentea	cyp-12³ cyn-12¹	Protein CYN-12¹	68(a) (best of 2)³ 61.67(n)¹ 68.13(a)¹		IV(7132411-7133401)³ 191627¹ NM_068717.2¹ NP_501118.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G36130¹	peptidyl-prolyl cis-trans isomerase-like 1	62.26(n) 65.41(a)		818186 NM_129172.5 NP_181157.1
rice (Oryza sativa)	Liliopsida	Os.5480²	Oryza sativa (japonica cultivar-group) OsCyp3 mRNA more	71.38(n)		AB067654.1
E. coli (Escherichia coli)	Gamma proteobacteria	ppiB⁶ ppiA⁶	peptidyl-prolyl cis-trans isomerase B (rotamase B)... peptidyl-prolyl cis-trans isomerase A (rotamase A)...	30(a) 28(a)	possible ortholog possible ortholog	Chromosome(553166-553660) Chromosome(3489747-3490319)

ENSEMBL Gene Tree for PPIL1 (if available)
TreeFam Gene Tree for PPIL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPIL1 gene

CWC27² PPIL4² PPWD1² PPIL3² PPIH² PPIB² PPIC² PPIL2²

18/21 SIMAP similar genes for PPIL1 using alignment to 1 protein entry: PPIL1_HUMAN(see all similar genes):

PPIL2 PPIC PPWD1 PPIB PPIA CWC27

PPIAL4A PPIAL4B PPIAL4C PPIAL4G RANBP2 PPIL3

PPIE PPIF PPIH LOC402252 NKTR PPID

PPIL1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PPIL1
PGOHUM00000240604

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11967922^1,2	C,F,H	--	36822122(+)	`ttcccC/Tctgca`	1	--	ds500¹		1		NA	120
rs116224656^1,2		--	36822162(+)	`CATGAG/CATCTG`	1	--	ds500¹		1		NA	120
rs192403698^1,2		--	36822184(+)	`ATGGTG/TGTTTC`	1	--	ds500¹		0	--	--	--	--
rs145612847^1,2		--	36822199(+)	`GTGCTC/TGCTCT`	1	--	ds500¹		0	--	--	--	--
rs145358544^1,2		--	36822237(+)	`CTTGCG/TTCTCC`	1	--	ds500¹		0	--	--	--	--
rs149182982^1,2		--	36822474(+)	`AGTCTA/TCTGGA`	1	--	ds500¹		0	--	--	--	--
rs184562507^1,2		--	36822509(+)	`AAATCC/TTGAAC`	1	--	ds500¹		0	--	--	--	--
rs189114952^1,2		--	36822513(+)	`CTTGAA/TCATTC`	1	--	ds500¹		0	--	--	--	--
rs181570714^1,2		--	36822542(+)	`TAAGAC/TGACTG`	1	--	ds500¹		0	--	--	--	--
rs79070450^1,2	C,F	--	36822593(+)	`TCAGAC/TCACAG`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for PPIL1 (36822603 - 36842800 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPIL1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PPIL1 for disorders           About GeneDecksing

OMIM gene information: 601301    OMIM disorders: --

2 diseases for PPIL1:    About MalaCards

colon cancer malaria

Export disorders for PPIL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPIL1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with PPIL1)

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Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain. (PubMed id 8978786)^{1, 2, 3, 9} Ozaki K....Shin S. (1996)
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PubMed id 20368803)^{1, 2, 9} Stegmann C.M....Wahl M.C. (2010)
Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PubMed id 16595688)^{1, 2, 9} Xu C.... Zhang Q. (2006)
Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PubMed id 10072585)^{1, 3, 9} Mann S.S....Hart T.C. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
A large intrinsically disordered region in SKIP and i ts disorder-order transition induced by PPIL1 binding revealed by NMR. (PubMed id 20007319)^{1, 9} Wang X....Shi Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51645	HGNC: 9260	AceView: PPIL1	Ensembl:ENSG00000137168	euGenes: HUgn51645
ECgene: PPIL1	Kegg: 51645	H-InvDB: PPIL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PPIL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PPIL1 gene
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Patent Information for PPIL1 gene:
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peptidylprolyl isomerase (cyclophilin)-like 1

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PPIL1 Gene

peptidylprolyl isomerase (cyclophilin)-like 1

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