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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIL1 Gene

protein-coding   GIFtS: 62
GCID: GC06M036869

Peptidylprolyl Isomerase (Cyclophilin)-Like 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase (Cyclophilin)-Like 11 2     Cyclophilin-Related Gene 12
CYPL12 3 5     hCyPX2
Rotamase PPIL12 3     Peptidyl-Prolyl Cis-Trans Isomerase2
PPIase2 3     Peptidyl-Prolyl Cis-Trans Isomerase-Like 12
EC 5.2.1.83 8     

External Ids:    HGNC: 92601   Entrez Gene: 516452   Ensembl: ENSG000001371687   OMIM: 6013015   UniProtKB: Q9Y3C63   

Export aliases for PPIL1 gene to outside databases

Previous GC identifers: GC06M036824 GC06M036930 GC06M036540


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIL1 Gene:
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a
highly conserved, ubiquitous family, members of which play an important role in protein folding,
immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this
protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPIL1 Gene: 
PPIL1 (peptidylprolyl isomerase (cyclophilin)-like 1) is a protein-coding gene. Diseases associated with PPIL1 include colon cancer, and pneumonia, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include protein binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

Gene Wiki entry for PPIL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIL1 gene promoter:
         TBP   NCX/Ncx   AP-2gamma   Ik-3   c-Ets-1   Pax-3   TFIID   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.1

PPIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036869:  view genomic region     (about GC identifiers)

Start:
36,822,603 bp from pter      End:
36,842,800 bp from pter
Size:
20,198 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase-like 1  
Size: 166 amino acids; 18237 Da
Subunit: Identified in the spliceosome C complex. Interacts with SNW1
3 PDB 3D structures from and Proteopedia for PPIL1:
1XWN (3D)        2K7N (3D)        2X7K (3D)    
Secondary accessions: O15001 Q5TDC9

Explore the universe of human proteins at neXtProt for PPIL1: NX_Q9Y3C6

Explore proteomics data for PPIL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3C6

  • 4/6 DME Specific Peptides for PPIL1 (Q9Y3C6) (see all 6)
     FMIQGGD  GDPTGTG  TNGSQFF  KHTIFGRV 

    PPIL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPIL1 Protein Expression
    REFSEQ proteins: NP_057143.1  
    ENSEMBL proteins: 
     ENSP00000362803  

    Human Recombinant Protein Products for PPIL1: 
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    Cloud-Clone Corp. Proteins for PPIL1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071013catalytic step 2 spliceosome IDA11991638

    PPIL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y3C6

    ProtoNet protein and cluster: Q9Y3C6

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIL1_HUMAN, Q9Y3C6
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. May be involved in pre-mRNA splicing
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by Cyclosporin A
    Biophysicochemical properties: Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide;

         Genatlas biochemistry entry for PPIL1:
    peptidylprolyl isomerase (cyclophilin)-like 1,cellular target of cyclosporin A

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding IPI16595688
         
    PPIL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPIL1:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Ppil1 (no phenotypes)

    PPIL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPIL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIL1 
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    hsa-miR-579 hsa-miR-4286 hsa-miR-1271 hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-3148 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPIL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPIL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for PPIL1):
        Spliceosome


    PPIL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for PPIL1 (Q9Y3C61, 2, 3 ENSP000003628034) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNW1Q135731, 3, ENSP000002615314EBI-2557649,EBI-632715 I2D: score=1 STRING: ENSP00000261531
    WDR83Q9BRX92, ENSP000002427964MINT-8332097 MINT-8337189 STRING: ENSP00000242796
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    SRRM2Q9UQ353, ENSP000003017404I2D: score=1 STRING: ENSP00000301740
    RBM42Q9BTD82, ENSP000002626334MINT-8337244 STRING: ENSP00000262633
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006457protein folding IEA--

    PPIL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIL1

    Search CenterWatch for drugs/clinical trials and news about PPIL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIL1 gene: 
    NM_016059.4  

    Unigene Cluster for PPIL1:

    Peptidylprolyl isomerase (cyclophilin)-like 1
    Hs.27693  [show with all ESTs]
    Unigene Representative Sequence: NM_016059
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483552 ENST00000373699(uc003omu.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIL1 (see all 16):
    hsa-miR-579 hsa-miR-4286 hsa-miR-1271 hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-3148 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPIL1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIL1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIL1

    Additional mRNA sequence: 

    AF151882.1 AK026636.1 AY359032.1 BC003048.1 

    10 DOTS entries:

    DT.116269  DT.95335508  DT.121337716  DT.100794526  DT.121337704  DT.121337732  DT.95171943  DT.318017 
    DT.40298481  DT.70101771 

    24/311 AceView cDNA sequences (see all 311):

    BF196840 BX103327 BU730177 AI824956 BP349162 BM764189 CR590493 AV716079 
    AW015641 CR591101 CA307328 BM785336 BF110487 BU688914 CR611473 D60023 
    CR592464 BM982200 BQ226329 BQ899063 BM695829 AL522960 CD723047 BU194242 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                    -                                 
    SP2:                    -     -                           
    SP3:                          -                           


    ECgene alternative splicing isoforms for PPIL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIL1 expression in normal human tissues (normalized intensities)      PPIL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCTCCTT
    PPIL1 Expression
    About this image


    PPIL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Liver (Hepatobiliary System)
             visceral organ/hepatic duct   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See PPIL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIL1

    SOURCE GeneReport for Unigene cluster: Hs.27693

    UniProtKB/Swiss-Prot: PPIL1_HUMAN, Q9Y3C6
    Tissue specificity: Ubiquitous, with the most abundant expression in heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIL1 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppil11 , 5 peptidylprolyl isomerase (cyclophilin)-like 11, 5 88.15(n)1
    98.19(a)1
      17 (15.15 cM)5
    688161  NM_026845.41  NP_081121.11 
     292508035 
    chicken
    (Gallus gallus)
    Aves LOC1008593321 peptidyl-prolyl cis-trans isomerase-like 1-like 73.24(n)
    84.35(a)
      100859332  XM_003643916.1  XP_003643964.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPIL16
    Peptidyl-prolyl cis-trans isomerase
    88(a)
    1 ↔ 1
    4(125098538-125101726)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985962 similar to peptidylprolyl isomerase (cyclophilin)-like more 74.98(n)    BC051602.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe11h122 Transcribed sequence with moderate similarity to protein more 79.13(n)    BM072075.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cypl1 , 3 peptidyl-prolyl cis-trans isomerase3
    Cyclophilin-like1
    76(a)3
    67.09(n)1
    76.1(a)1
      61C33
    380691  NM_079150.31  NP_523874.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-123
    cyn-121
    Protein CYN-121 68(a)
    (best of 2)3
    61.67(n)1
    68.13(a)1
      IV(7132411-7133401)3
    1916271  NM_068717.21  NP_501118.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR26
    CPR56
    Peptidyl-prolyl cis-trans isomerase (cyclophilin),...
    Peptidyl-prolyl cis-trans isomerase (cyclophilin) ...
    36(a)
    31(a)
    many ↔ many
    many ↔ many
    VIII(218226-218843)
    IV(1071880-1072557)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G361301 peptidyl-prolyl cis-trans isomerase-like 1 62.26(n)
    65.41(a)
      818186  NM_129172.5  NP_181157.1 
    rice
    (Oryza sativa)
    Liliopsida Os.54802 Oryza sativa (japonica cultivar-group) OsCyp3 mRNA more 71.38(n)    AB067654.1 


    ENSEMBL Gene Tree for PPIL1 (if available)
    TreeFam Gene Tree for PPIL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIL1 gene
    PPIH2  PPIC2  PPIB2  CWC272  PPIL42  PPWD12  PPIL22  PPIL32  
    18/22 SIMAP similar genes for PPIL1 using alignment to 1 protein entry:     PPIL1_HUMAN(see all similar genes):
    PPIL2    PPIC    PPWD1    PPIB    PPIA    CWC27
    PPIAL4D    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G    RANBP2
    PPIL3    PPIE    PPIF    PPIH    LOC402252    NKTR

    PPIL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPIL1
    PGOHUM00000240604


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/512 SNPs in PPIL1 are shown (see all 512)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119679221,2
    C,F,H--36822122(+) ttcccC/Tctgca 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1162246561,2
    F--36822162(+) CATGAG/CATCTG 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1924036981,2
    --36822184(+) ATGGTG/TGTTTC 1 -- ds50010--------
    rs1456128471,2
    --36822199(+) GTGCTC/TGCTCT 1 -- ds50010--------
    rs1453585441,2
    C--36822237(+) CTTGCG/TTCTCC 1 -- ds50010--------
    rs1491829821,2
    --36822474(+) AGTCTA/TCTGGA 1 -- ds50010--------
    rs1845625071,2
    --36822509(+) AAATCC/TTGAAC 1 -- ds50010--------
    rs1891149521,2
    --36822513(+) CTTGAA/TCATTC 1 -- ds50010--------
    rs1815707141,2
    --36822542(+) TAAGAC/TGACTG 1 -- ds50010--------
    rs790704501,2
    C,F--36822593(+) TCAGAC/TCACAG 1 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for PPIL1 (36822603 - 36842800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPIL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5262CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601301    OMIM disorders: --

    2 diseases for PPIL1:    About MalaCards
    colon cancer    pneumonia


    PPIL1 for disorders           About GeneDecksing


    Export disorders for PPIL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIL1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with PPIL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain. (PubMed id 8978786)1, 2, 3, 9 Ozaki K....Shin S. (1996)
    2. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PubMed id 20368803)1, 2, 9 Stegmann C.M....Wahl M.C. (2010)
    3. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PubMed id 16595688)1, 2, 9 Xu C.... Zhang Q. (2006)
    4. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PubMed id 10072585)1, 3, 9 Mann S.S....Hart T.C. (1998)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    9. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    10. A large intrinsically disordered region in SKIP and i ts disorder-order transition induced by PPIL1 binding revealed by NMR. (PubMed id 20007319)1, 9 Wang X....Shi Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51645 HGNC: 9260 AceView: PPIL1 Ensembl:ENSG00000137168 euGenes: HUgn51645
    ECgene: PPIL1 Kegg: 51645 H-InvDB: PPIL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIL1 gene:
    Search GeneIP for patents involving PPIL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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