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PPIH Gene

protein-coding   GIFtS: 62
GCID: GC01P043097

Peptidylprolyl Isomerase H (Cyclophilin H)

(Previous name: peptidyl prolyl isomerase H (cyclophilin H))
  Search for PPIH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase H (Cyclophilin H)1 2     USA-CYP2 3
PPIase H1 2 3     U-SnRNP-Associated Cyclophilin SnuCyp-202 3
Rotamase H1 2 3     EC 5.2.1.83 8
Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H1 2 3     Peptidyl Prolyl Isomerase H (Cyclophilin H)1
Cyclophilin H1 2     CYP-202
Peptidyl-Prolyl Cis-Trans Isomerase H1 2     SnuCyp-202
U-SnRNP-Associated Cyclophilin SunCyp-201 2     CYP203
USA-CyP SnuCyp-201 2     CypH3
CYPH2 3     

External Ids:    HGNC: 146511   Entrez Gene: 104652   Ensembl: ENSG000001719607   OMIM: 6060955   UniProtKB: O434473   

Export aliases for PPIH gene to outside databases

Previous GC identifers: GC01P042127 GC01P042587 GC01P042537 GC01P042793 GC01P042897 GC01P041244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPIH Gene:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding
of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3,
PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may
act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PPIH Gene:
PPIH (peptidylprolyl isomerase H (cyclophilin H)) is a protein-coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is CWC27.

UniProtKB/Swiss-Prot: PPIH_HUMAN, O43447
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the
U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone

Gene Wiki entry for PPIH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIH gene promoter:
         HOXA9B   HOXA9   Max1   AP-1   ATF-2   Meis-1b   YY1   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIH promoter sequence
   Search Chromatin IP Primers for PPIH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.1

PPIH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043097:  view genomic region     (about GC identifiers)

Start:
43,124,048 bp from pter      End:
43,142,429 bp from pter
Size:
18,382 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPIH_HUMAN, O43447 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase H  
Size: 177 amino acids; 19208 Da
Subunit: Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is
stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs
and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2,
SART1 and USP39. Heterodimer with PRPF18
2 PDB 3D structures from and Proteopedia for PPIH:
1MZW (3D)        1QOI (3D)    

Explore the universe of human proteins at neXtProt for PPIH: NX_O43447

Explore proteomics data for PPIH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38, Lys61, Lys101
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIH (O43447) (see all 9)
     PKTAENF  GLLSMAN  FMIQGGD  DVVPKTA 


    See PPIH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006338.1  
    ENSEMBL proteins: 
     ENSP00000306614   ENSP00000361630   ENSP00000402836   ENSP00000361629   ENSP00000405493  
     ENSP00000436091   ENSP00000416361  

    PPIH Human Recombinant Protein Products:

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    Novus Biologicals PPIH Proteins
    Novus Biologicals PPIH Lysate
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    Cloud-Clone Corp. Proteins for PPIH

     
    Search eBioscience for Proteins for PPIH 

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    PPIH Assay Products:

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    Cloud-Clone Corp. CLIAs for PPIH
    Search eBioscience for ELISAs for PPIH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry O43447

    ProtoNet protein and cluster: O43447

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIH_HUMAN, O43447
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase H subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Find genes that share domains with PPIH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIH_HUMAN, O43447
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the
    U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by cyclosporin A

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA9570313
    GO:0005515protein binding IPI19615732
    GO:0016018cyclosporin A binding TAS9570313
    GO:0043021ribonucleoprotein complex binding IDA9570313
         
    Find genes that share ontologies with PPIH           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPIH:
     G2 arrest  Increased G2M DNA content  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPIH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIH

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate PPIH:
    hsa-miR-582-5p hsa-miR-424 hsa-miR-15a hsa-miR-16 hsa-miR-497 hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidPPIH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPIH
    Predesigned siRNA for gene silencing in human, mouse, rat PPIH

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PPIH (NM_006347)
    Sino Biological Human cDNA Clone for PPIH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIH

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIH_HUMAN, O43447: Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion
    may also be cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex IC9570313
    GO:0005737cytoplasm IDA9570313
    GO:0016607nuclear speck IDA9570313
    GO:0046540U4/U6 x U5 tri-snRNP complex IDA9570313
    GO:0071001U4/U6 snRNP IDA9570313

    Find genes that share ontologies with PPIH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPIH About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome


    Find genes that share SuperPaths with PPIH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for PPIH):
        Spliceosome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPIH: Housekeeping Genes PCR Array
    Interactions:

        GeneGlobe Interaction Network for PPIH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for PPIH (O434471, 2, 3 ENSP000003066144) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF4O431721, 2, 3, ENSP000003633134EBI-1055615,EBI-718395 MINT-16268 MINT-8336485 MINT-25058 I2D: score=5 STRING: ENSP00000363313
    PRPF18Q996333, ENSP000003678354I2D: score=2 STRING: ENSP00000367835
    USP4Q131073, ENSP000002655604I2D: score=2 STRING: ENSP00000265560
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC9570313
    GO:0000413protein peptidyl-prolyl isomerization IDA9570313
    GO:0006457protein folding IEA--
    GO:0006461protein complex assembly TAS9570313
    GO:0045070positive regulation of viral genome replication IMP19932913

    Find genes that share ontologies with PPIH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIH

    1 HMDB Compound for PPIH    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    1 DrugBank Compound for PPIH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPIH gene: 
    NM_006347.3  

    Unigene Cluster for PPIH:

    Peptidylprolyl isomerase H (cyclophilin H)
    Hs.256639  [show with all ESTs]
    Unigene Representative Sequence: AK294288
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304979(uc001chq.3) ENST00000372550 ENST00000440068 ENST00000372549
    ENST00000436387 ENST00000461351 ENST00000455203(uc009vwl.2 uc021omf.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat PPIH using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PPIH:
    hsa-miR-582-5p hsa-miR-424 hsa-miR-15a hsa-miR-16 hsa-miR-497 hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidPPIH 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PPIH
    Predesigned siRNA for gene silencing in human, mouse, rat PPIH
    Clone
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    OriGene ORF clones in mouse, rat for PPIH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIH (NM_006347)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIH
    Primer
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    OriGene qPCR primer pairs and template standards for PPIH
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIH
      QuantiTect SYBR Green Assays in human, mouse, rat PPIH
      QuantiFast Probe-based Assays in human, mouse, rat PPIH

    Additional mRNA sequence: 

    AF016371.1 AF036331.1 AK294288.1 AK309438.1 AK310052.1 AK311979.1 BC003412.1 BT019343.1 
    CR541899.1 CR541920.1 

    17 DOTS entries:

    DT.99930694  DT.315394  DT.121441160  DT.303450  DT.91822865  DT.92424856  DT.121441182  DT.86854997 
    DT.121441184  DT.92424858  DT.121441042  DT.121441083  DT.91927044  DT.92053790  DT.121441117  DT.121441176 
    DT.40114509 

    Selected AceView cDNA sequences (see all 160):

    AF086102 AA833745 AI268811 BM458635 BU849571 AI659243 N57462 BX114760 
    AA593915 AA403116 AA401841 AI018151 CB850550 AU151145 BM460052 AA593855 
    NM_006347 BC003412 BQ948200 AA639807 BU733220 CA306787 CR541920 BG678150 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PPIH    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -     -                 -                 -                                 
    SP2:                    -     -                                   -                                 
    SP3:                    -     -                                                                     
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for PPIH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTGTCAG
    PPIH Expression
    About this image


    PPIH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    PPIH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256639
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPIH: Housekeeping Genes PCR Array
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPIH
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIH
    QuantiTect SYBR Green Assays in human, mouse, rat PPIH
    QuantiFast Probe-based Assays in human, mouse, rat PPIH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIH gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppih1 , 5 peptidyl prolyl isomerase H1, 5 92.66(n)1
    100(a)1
      4 (55.34 cM)5
    661011  NM_028677.41  NP_082953.11 
     1193000105 
    chicken
    (Gallus gallus)
    Aves PPIH1 peptidylprolyl isomerase H (cyclophilin H) 80.41(n)
    95.48(a)
      419507  NM_001277912.1  NP_001264841.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480331792   -- 82.28(n)    48033179 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557662 similar to peptidyl prolyl isomerase H (cyclophilin more 78.13(n)   394180  AY394969.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172661 , 3 mRNA splicing peptidyl-prolyl cis-trans
    isomerase3
    CG172661
    79(a)
    (best of 2)3
    68.62(n)1
    78.36(a)1
      42C33
    355711  NM_136380.31  NP_610224.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-113
    cyn-111
    peptidyl-prolyl cis-trans isomerase3
    cyn-111
    70(a)
    (best of 2)3
    63.92(n)1
    70.59(a)1
      II(8715023-8716335)3
    1743941  NM_063454.51  NP_495855.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR26
    CPR56
    Peptidyl-prolyl cis-trans isomerase (cyclophilin),...
    Peptidyl-prolyl cis-trans isomerase (cyclophilin) ...
    43(a)
    37(a)
    many ↔ many
    many ↔ many
    VIII(218226-218843) YHR057C
    IV(1071880-1072557) YDR304C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G387301 AT2G38730 68.81(n)
    73.68(a)
      818455  NM_129430.3  NP_181407.1 
    rice
    (Oryza sativa)
    Liliopsida Os.279812 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.96(n)    AK071076.1 


    ENSEMBL Gene Tree for PPIH (if available)
    TreeFam Gene Tree for PPIH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIH gene
    CWC272  PPWD12  PPIL42  PPIL32  PPIB2  PPIC2  PPIL12  PPIL22  
    Selected SIMAP similar genes for PPIH using alignment to 8 protein entries:     PPIH_HUMAN (see all proteins) (see all similar genes):
    PPIE    PPIF    PPIB    PPIA    PPIC    RANBP2
    PPID    PPIAL4G    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4D
    PPIL6    NKTR    PPIL1    DKFZp686G0426    PPIG    PPIL2

    Find genes that share paralogs with PPIH           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PPIH
    PGOHUM00000242485 PGOHUM00000262574 PGOHUM00000241954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIH (see all 371)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390583621,2
    --43122068(+) AGGCCA/GAGGCA 1 -- us2k10--------
    rs118101201,2
    C,H--43122086(+) cacttG/Caggcc 1 -- us2k1 tfbs31Minor allele frequency- C:0.50NA 2
    rs1461381571,2
    --43122130(+) AGCCCA/TGTCTC 1 -- us2k10--------
    rs1398901791,2
    --43122176(+) GCACAC/GCTGTA 1 -- us2k10--------
    rs118006601,2
    C,F,H--43122242(+) AGTTTC/AAGTGA 1 -- us2k14Minor allele frequency- A:0.08WA NA 244
    rs1129112091,2
    F--43122316(+) AATAAT/AAAATA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1887392411,2
    C--43122491(+) TAGCAC/TGTAGT 1 -- us2k10--------
    rs1488146461,2
    C--43122515(+) ATGCT-/ATCATCAT 1 -- us2k10--------
    rs1447853281,2
    --43122537(+) CTAGAA/GGTTTA 1 -- us2k10--------
    rs1485416691,2
    --43122638(+) GAAGCA/GTGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIH (43124048 - 43142429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPIH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671740CNV Deletion23128226
    nsv829682CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIH
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606095    OMIM disorders: --


    Find genes that share disorders with PPIH           About GenesLikeMe


    Export disorders for PPIH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIH gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with PPIH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. (PubMed id 9570313)1, 2, 3 Teigelkamp S.... Luehrmann R. (RNA 1998)
    2. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. (PubMed id 9404889)1, 2, 3 Horowitz D.S.... Krainer A.R. (RNA 1997)
    3. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (RNA 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. (PubMed id 12875835)1, 2 Reidt U....Ficner R. (J. Mol. Biol. 2003)
    6. A cyclophilin functions in pre-mRNA splicing. (PubMed id 11823439)1, 2 Horowitz D.S.... Misteli T. (EMBO J. 2002)
    7. Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin. (PubMed id 10713041)1, 2 Reidt U....Ficner R. (J. Biol. Chem. 2000)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10465 HGNC: 14651 AceView: PPIH Ensembl:ENSG00000171960 euGenes: HUgn10465
    ECgene: PPIH Kegg: 10465 H-InvDB: PPIH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPIH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPIH gene:
    Search GeneIP for patents involving PPIH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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