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Aliases for PPIH Gene

Aliases for PPIH Gene

  • Peptidylprolyl Isomerase H 2 3
  • Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H 2 3 4
  • Rotamase H 2 3 4
  • PPIase H 2 3 4
  • Peptidylprolyl Isomerase H (Cyclophilin H) 3 5
  • U-SnRNP-Associated Cyclophilin SunCyp-20 2 3
  • U-SnRNP-Associated Cyclophilin SnuCyp-20 3 4
  • USA-CyP SnuCyp-20 2 3
  • Cyclophilin H 2 3
  • EC 5.2.1.8 4 63
  • USA-CYP 3 4
  • CYPH 3 4
  • Peptidyl Prolyl Isomerase H (Cyclophilin H) 2
  • Peptidyl-Prolyl Cis-Trans Isomerase H 2
  • SnuCyp-20 3
  • CYP-20 3
  • CYP20 4

External Ids for PPIH Gene

Previous GeneCards Identifiers for PPIH Gene

  • GC01P043097
  • GC01P042127
  • GC01P042537
  • GC01P042793
  • GC01P042897
  • GC01P041244

Summaries for PPIH Gene

Entrez Gene Summary for PPIH Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIH Gene

PPIH (Peptidylprolyl Isomerase H) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIH Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.

Gene Wiki entry for PPIH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIH Gene

Genomics for PPIH Gene

Regulatory Elements for PPIH Gene

Enhancers for PPIH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIH on UCSC Golden Path with GeneCards custom track

Promoters for PPIH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIH on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIH Gene

Chromosome:
1
Start:
42,657,770 bp from pter
End:
42,681,654 bp from pter
Size:
23,885 bases
Orientation:
Plus strand

Genomic View for PPIH Gene

Genes around PPIH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIH Gene

Proteins for PPIH Gene

  • Protein details for PPIH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43447-PPIH_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase H
    Protein Accession:
    O43447
    Secondary Accessions:
    • A6NNE7

    Protein attributes for PPIH Gene

    Size:
    177 amino acids
    Molecular mass:
    19208 Da
    Quaternary structure:
    • Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Heterodimer with PRPF18.

    Three dimensional structures from OCA and Proteopedia for PPIH Gene

    Alternative splice isoforms for PPIH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIH Gene

Proteomics data for PPIH Gene at MOPED

Selected DME Specific Peptides for PPIH Gene

Post-translational modifications for PPIH Gene

  • Ubiquitination at Lys 61 and Lys 101
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIH Gene

Domains & Families for PPIH Gene

Gene Families for PPIH Gene

Graphical View of Domain Structure for InterPro Entry

O43447

UniProtKB/Swiss-Prot:

PPIH_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
genes like me logo Genes that share domains with PPIH: view

Function for PPIH Gene

Molecular function for PPIH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cyclosporin A.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.

Enzyme Numbers (IUBMB) for PPIH Gene

genes like me logo Genes that share phenotypes with PPIH: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIH

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIH Gene

Localization for PPIH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIH Gene

Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIH Gene COMPARTMENTS Subcellular localization image for PPIH gene
Compartment Confidence
nucleus 5
cytosol 3
chloroplast 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPIH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9570313
GO:0016607 nuclear speck IDA 9570313
genes like me logo Genes that share ontologies with PPIH: view

Pathways & Interactions for PPIH Gene

genes like me logo Genes that share pathways with PPIH: view

Pathways by source for PPIH Gene

Gene Ontology (GO) - Biological Process for PPIH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006461 protein complex assembly TAS 9570313
genes like me logo Genes that share ontologies with PPIH: view

No data available for SIGNOR curated interactions for PPIH Gene

Drugs & Compounds for PPIH Gene

(1) Drugs for PPIH Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
genes like me logo Genes that share compounds with PPIH: view

Transcripts for PPIH Gene

Unigene Clusters for PPIH Gene

Peptidylprolyl isomerase H (cyclophilin H):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for PPIH Gene

GeneLoc Exon Structure for
PPIH
ECgene alternative splicing isoforms for
PPIH

Expression for PPIH Gene

mRNA expression in normal human tissues for PPIH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIH Gene



SOURCE GeneReport for Unigene cluster for PPIH Gene Hs.256639

genes like me logo Genes that share expression patterns with PPIH: view

Protein tissue co-expression partners for PPIH Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIH Gene

Orthologs for PPIH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIH 35
  • 92.66 (n)
  • 100 (a)
PPIH 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIH 35
  • 93.79 (n)
  • 100 (a)
PPIH 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppih 35
  • 92.66 (n)
  • 100 (a)
Ppih 16
Ppih 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIH 35
  • 99.81 (n)
  • 100 (a)
PPIH 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppih 35
  • 93.56 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIH 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIH 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIH 35
  • 80.41 (n)
  • 95.48 (a)
PPIH 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76244 35
ppih 35
  • 79.66 (n)
  • 91.53 (a)
zebrafish
(Danio rerio)
Actinopterygii ppih 35
  • 76.27 (n)
  • 87.57 (a)
zgc55766 35
ppih 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8742 35
fruit fly
(Drosophila melanogaster)
Insecta CG17266 37
  • 79 (a)
ninaA 37
  • 46 (a)
CG17266 35
  • 68.62 (n)
  • 78.36 (a)
CG17266 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007392 35
  • 69.01 (n)
  • 79.53 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-11 37
  • 70 (a)
cyp-8 37
  • 55 (a)
cyn-11 35
  • 63.92 (n)
  • 70.59 (a)
cyn-11 36
  • 66 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 36
  • 43 (a)
ManyToMany
CPR5 36
  • 37 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G38730 35
  • 68.81 (n)
  • 73.68 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2140 35
rice
(Oryza sativa)
Liliopsida Os.27981 35
Os03g0811600 35
  • 66.86 (n)
  • 71.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.18236 35
corn
(Zea mays)
Liliopsida Zm.2051 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4482 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02614 35
  • 62.3 (n)
  • 65.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp3 35
  • 58.78 (n)
  • 62.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.534 36
  • 72 (a)
OneToOne
Species with no ortholog for PPIH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIH Gene

ENSEMBL:
Gene Tree for PPIH (if available)
TreeFam:
Gene Tree for PPIH (if available)

Paralogs for PPIH Gene

Paralogs for PPIH Gene

Pseudogenes.org Pseudogenes for PPIH Gene

genes like me logo Genes that share paralogs with PPIH: view

Variants for PPIH Gene

Sequence variations from dbSNP and Humsavar for PPIH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12244 -- 42,665,982(+) CAGGC(A/C/G)AACAG nc-transcript-variant, reference, synonymous-codon
rs912074 -- 42,678,350(+) ATGCA(C/T)GGTGG intron-variant
rs1198099 -- 42,671,335(-) ttctc(A/C/G)tgcct intron-variant
rs1198100 -- 42,671,276(-) taatt(C/T)ttgta intron-variant
rs1198101 -- 42,671,270(-) ttgta(A/T)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIH Gene

Variant ID Type Subtype PubMed ID
nsv829682 CNV Loss 17160897
esv2671740 CNV Deletion 23128226

Variation tolerance for PPIH Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIH Gene

HapMap Linkage Disequilibrium report
PPIH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIH Gene

Disorders for PPIH Gene

Relevant External Links for PPIH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIH

No disorders were found for PPIH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIH Gene

Publications for PPIH Gene

  1. The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. (PMID: 9570313) Teigelkamp S. … Luehrmann R. (RNA 1998) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. (PMID: 9404889) Horowitz D.S. … Krainer A.R. (RNA 1997) 2 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PPIH Gene

Sources for PPIH Gene

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