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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIG Gene

protein-coding   GIFtS: 65
GCID: GC02P170404

Peptidylprolyl Isomerase G (Cyclophilin G)

(Previous name: peptidyl-prolyl isomerase G (cyclophilin G))
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase G (Cyclophilin G)1 2     Clk-Associating RS-Cyclophilin2 3
Peptidyl-Prolyl Isomerase G (Cyclophilin G)1 2     PPIase G2 3
SR-Related CTD-Associated Factor 101 2     EC 5.2.1.83 8
Cyclophilin G2 3     CYP2
Rotamase G2 3     SCAF102
CARS-Cyp2 3     SRCyp2
CARS-cyclophilin2 3     Peptidyl-Prolyl Cis-Trans Isomerase G2
CASP102 3     SRcyp3
SR-cyclophilin2 3     Peptidyl-Prolyl Isomerase G3
SR-cyp2 3     

External Ids:    HGNC: 146501   Entrez Gene: 93602   Ensembl: ENSG000001383987   OMIM: 6060935   UniProtKB: Q134273   

Export aliases for PPIG gene to outside databases

Previous GC identifers: GC02P168492 GC02P168982 GC02P170643 GC02P170266 GC02P170150 GC02P162331


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPIG Gene: 
PPIG (peptidylprolyl isomerase G (cyclophilin G)) is a protein-coding gene. Diseases associated with PPIG include bladder disease, and proctitis. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is NKTR.

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play
an important role in the regulation of pre-mRNA splicing

summary for PPIG Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for PPIG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIG gene promoter:
         AhR   C/EBPbeta   Sp1   AP-1   ATF-2   Nkx2-5   c-Jun   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIG promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

PPIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170404:  view genomic region     (about GC identifiers)

Start:
170,440,850 bp from pter      End:
170,497,916 bp from pter
Size:
57,067 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase G  
Size: 754 amino acids; 88617 Da
Subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II
Subcellular location: Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear
speckles
3 PDB 3D structures from and Proteopedia for PPIG:
2GW2 (3D)        2WFI (3D)        2WFJ (3D)    
Secondary accessions: D3DPC5 D3DPC6 O00706 Q53R40 Q53SN4 Q96DG9
Alternative splicing: 2 isoforms:  Q13427-1   Q13427-2   

Explore the universe of human proteins at neXtProt for PPIG: NX_Q13427

Explore proteomics data for PPIG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13427

  • 4/5 DME Specific Peptides for PPIG (Q13427) (see all 5)
     GGESIYG  LCTGEKG  PKTCENF  DKYKNKV 

    PPIG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPIG Protein Expression
    REFSEQ proteins: NP_004783.2  
    ENSEMBL proteins: 
     ENSP00000260970   ENSP00000408683   ENSP00000386245   ENSP00000435987   ENSP00000407083  
     ENSP00000394202   ENSP00000402222   ENSP00000411643  

    Human Recombinant Protein Products for PPIG: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PPIG
    Cloud-Clone Corp. Proteins for PPIG 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS9153302
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016363nuclear matrix IEA--

    PPIG for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PPIG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry Q13427

    ProtoNet protein and cluster: Q13427

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427
    Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase
    II
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIG_HUMAN, Q13427
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play
    an important role in the regulation of pre-mRNA splicing
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA)-sensitive

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding IPI--
    GO:0016018cyclosporin A binding TAS9153302
         
    PPIG for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-374b* hsa-miR-548a-3p hsa-miR-4274 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidPPIG 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPIG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PPIG
        Translational Control

    2 Tocris Bioscience Pathways for PPIG
        Apoptosis Pathway
    VEGF Pathway




    PPIG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/20 Interacting proteins for PPIG (Q134272, 3 ENSP000002609704) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50844 I2D: score=4 STRING: ENSP00000306330
    PCBP1Q153652, ENSP000003055564MINT-8332119 MINT-8338080 STRING: ENSP00000305556
    PNNQ9H3073, ENSP000002168324I2D: score=3 STRING: ENSP00000216832
    CLK1P497593, ENSP000003268304I2D: score=2 STRING: ENSP00000326830
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0008380RNA splicing TAS9153302

    PPIG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPIG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PPIG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    1 HMDB Compound for PPIG    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    1 DrugBank Compound for PPIG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    10/161 Novoseek inferred chemical compound relationships for PPIG gene (see all 161)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfaphenazole 91.2 16 10077440 (2), 8267647 (1), 8654202 (1), 16875977 (1) (see all 13)
    furafylline 90.2 3 11136295 (1), 20081260 (1), 12399157 (1)
    chlorzoxazone 89.8 26 10534312 (2), 8053924 (1), 10589936 (1), 10510277 (1) (see all 21)
    troleandomycin 88 10 19616568 (1), 8267647 (1), 8735469 (1), 10661723 (1) (see all 8)
    phenacetin 85.5 19 10548449 (2), 10901704 (1), 10917566 (1), 10805063 (1) (see all 17)
    ketoconazole 85.2 18 8053924 (2), 10598746 (1), 11136295 (1), 19302901 (1) (see all 16)
    bufuralol 84.8 9 11523064 (1), 15618695 (1), 10805063 (1), 11037108 (1) (see all 9)
    ethoxyresorufin 83.5 17 9464470 (1), 10917566 (1), 11523064 (1), 16615094 (1) (see all 17)
    alpha-naphthoflavone 82.5 6 8267647 (1), 8654202 (1), 11640917 (1), 12514286 (1) (see all 5)
    tolbutamide 82 21 14749695 (2), 8053924 (1), 9522439 (1), 10901704 (1) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about PPIG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIG gene: 
    NM_004792.2  

    Unigene Cluster for PPIG:

    Peptidylprolyl isomerase G (cyclophilin G)
    Hs.470544  [show with all ESTs]
    Unigene Representative Sequence: U40763
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260970(uc002uez.3 uc010fpx.3 uc010fpy.3 uc002ufb.3 uc002ufd.3)
    ENST00000433207 ENST00000409714 ENST00000530152 ENST00000462903(uc002ufa.3)
    ENST00000448752 ENST00000418888 ENST00000414307(uc002ufc.1) ENST00000417938
    ENST00000482772 ENST00000466142

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIG:
    hsa-miR-374b* hsa-miR-548a-3p hsa-miR-4274 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidPPIG 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK307552.1 BC001555.1 BC063711.1 BC073875.1 BC109373.1 BC111693.1 U40763.1 X99717.1 

    22 DOTS entries:

    DT.80100810  DT.95313139  DT.40298763  DT.95151215  DT.99974500  DT.92353152  DT.121009925  DT.121009922 
    DT.92440961  DT.101972912  DT.100030664  DT.121009903  DT.121009951  DT.426676  DT.91647489  DT.91808753 
    DT.95167383  DT.100033355  DT.102841402  DT.40200055  DT.91698421  DT.95112363 

    24/466 AceView cDNA sequences (see all 466):

    AW043970 AU135498 AI955027 BQ880972 BM968123 AI032414 CB132861 X99717 
    BM684410 BP375607 BM930833 CA420226 BM463543 BG150409 BM972263 AI919249 
    D30859 BU675131 BG112380 BQ271772 BM794950 CB123725 AL700290 AA576807 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIG expression in normal human tissues (normalized intensities)      PPIG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAAACAA
    PPIG Expression
    About this image


    PPIG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cmps   
     
     Breast
             breast ; myoepithelial cells   
             breast ductal cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See PPIG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIG

    SOURCE GeneReport for Unigene cluster: Hs.470544

    UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPIG gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppig1 , 5 peptidyl-prolyl isomerase G (cyclophilin G)1, 5 89.97(n)1
    93.61(a)1
      2 (40.95 cM)5
    2280051  NM_001081086.11  NP_001074555.11 
     697225455 
    chicken
    (Gallus gallus)
    Aves PPIG1 peptidylprolyl isomerase G (cyclophilin G) 77.51(n)
    78.09(a)
      424162  XM_422008.3  XP_422008.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPIG6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343362.1(475506-495659)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45132 Xenopus laevis transcribed sequence with moderate similarity more 80.15(n)    BU910998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.181742 Danio rerio mRNA similar to matrin cyclophilin (matrin-cyp) more 72.73(n)    BC044189.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0029521 AGAP002952-PA 42.65(n)
    39.11(a)
      1273012  XM_311948.4  XP_311948.4 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-83
    cyn-81
    Expression: intestine, pharynx, embryo,
    L1 larva, more3
    Protein CYN-81
    57(a)3
    44.47(n)1
    36.32(a)1
      X(8946628-8949076)3
    1811361  NM_077105.31  NP_509506.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR66
    Peptidyl-prolyl cis-trans isomerase (cyclophilin),...
    33(a)
    1 → many
    XII(572096-573211)


    ENSEMBL Gene Tree for PPIG (if available)
    TreeFam Gene Tree for PPIG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIG gene
    NKTR2  PPID2  PPIL62  
    18/23 SIMAP similar genes for PPIG using alignment to 10 protein entries:     PPIG_HUMAN (see all proteins) (see all similar genes):
    DKFZp686G0426    NKTR    PPID    PPIL6    PPIB    RANBP2
    PPIF    PPIC    PPIE    PPWD1    PPIH    PPIA
    PPIL3    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G    PPIAL4D

    PPIG for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPIG
    PGOHUM00000235819


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1283 SNPs in PPIG are shown (see all 1283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883632371,2
    --170438868(+) AACTAC/TAGGAT 1 -- us2k10--------
    rs1494810531,2
    C--170438877(+) ATAAC-/AAATGTT 1 -- us2k10--------
    rs1459008291,2
    C--170438933(+) TTTTA-/TT    
       TAACT
    TTTAA
    1 -- us2k10--------
    rs1181380061,2
    C,F--170439011(+) TATTTC/TATCAC 1 -- us2k11Minor allele frequency- T:0.07EA 120
    rs796188301,2
    C--170439091(+) TGATAG/CGCCCC 1 -- us2k14Minor allele frequency- C:0.12WA NA EA 360
    rs1150426101,2
    C,F--170439106(+) TGTATT/CGTGCC 1 -- us2k13Minor allele frequency- C:0.42WA NA EA 358
    rs1810017171,2
    --170439120(+) CTATGC/TCTTCA 1 -- us2k10--------
    rs794050731,2
    C--170439313(+) TATCAA/CGTCTA 1 -- us2k10--------
    rs1858797881,2
    --170439384(+) ACATAC/TATATG 1 -- us2k10--------
    rs1397757391,2
    --170439406(+) ATAACA/CGAACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIG (170440850 - 170497916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PPIG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721116CNV Deletion23290073
    esv2721115CNV Deletion23290073
    nsv520764CNV Loss19592680
    nsv3025CNV Loss18451855
    nsv834454CNV Loss17160897
    dgv4358n71CNV Loss21882294
    dgv4359n71CNV Loss21882294
    nsv518894CNV Gain19592680


    Human Gene Mutation Database (HGMD): PPIG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIG
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606093    OMIM disorders: --

    20/65 diseases for PPIG (see all 65):    About MalaCards
    bladder disease    proctitis    myocardial infarction    liver disease
    barrett's esophagus    porphyria    hypertriglyceridemia    adrenocortical carcinoma
    alzheimer's disease    cystitis    cytochrome p450    hyperglycemia
    endometriosis    severe combined immunodeficiency    myelodysplastic syndromes    hyperparathyroidism
    fatty liver disease    autism spectrum disorder    vaccinia    influenza

    5 diseases from the University of Copenhagen DISEASES database for PPIG:
    Liver disease     Heart disease     Breast cancer     Lung cancer
    Hypertension

    PPIG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/82 Novoseek inferred disease relationships for PPIG gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chemical carcinogenesis 38.1 2 9486585 (1), 19858070 (1)
    cancer 24.3 36 15828850 (2), 9255558 (2), 10667460 (2), 15180491 (2) (see all 27)
    porphyria 18.9 1 10964007 (1)
    liver diseases 15.1 6 19533803 (1), 10589374 (1), 12569554 (1), 8672739 (1) (see all 5)
    liver dysfunction 12.3 2 12867215 (1), 15753745 (1)
    rhabdomyolysis 9.89 1 11936570 (1)
    cancer lung 9.18 3 7620940 (1), 17127240 (1), 9364212 (1)
    psychiatric disorder 5.43 1 9579322 (1)
    hyperglycemia 5.24 1 10522495 (1)
    adenoma 5.12 1 16281975 (1)

    Genetic Association Database (GAD): PPIG
    Human Genome Epidemiology (HuGE) Navigator: PPIG (1 document)

    Export disorders for PPIG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIG gene, integrated from 9 sources (see all 857):
    (articles sorted by number of sources associating them with PPIG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. (PubMed id 9153302)1, 2, 3 Bourquin J.-P.... Schaffner W. (1997)
    2. RS cyclophilins: identification of an NK-TR1-related cyclophilin. (PubMed id 8973360)1, 2, 3 Nestel F.P.... Anderson S.K. (1996)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. (PubMed id 15358154)1, 2 Lin C.L.... Ouyang P. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    8. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    9. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9360 HGNC: 14650 AceView: PPIG Ensembl:ENSG00000138398 euGenes: HUgn9360
    ECgene: PPIG H-InvDB: PPIG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIG gene:
    Search GeneIP for patents involving PPIG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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