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Aliases for PPIG Gene

Aliases for PPIG Gene

  • Peptidylprolyl Isomerase G (Cyclophilin G) 2 3
  • Peptidyl-Prolyl Isomerase G (Cyclophilin G) 2 3
  • SR-Related CTD-Associated Factor 10 2 3
  • Clk-Associating RS-Cyclophilin 3 4
  • CARS-Cyclophilin 3 4
  • SR-Cyclophilin 3 4
  • Cyclophilin G 3 4
  • Rotamase G 3 4
  • EC 5.2.1.8 4 63
  • PPIase G 3 4
  • CARS-Cyp 3 4
  • CASP10 3 4
  • SR-Cyp 3 4
  • SRCyp 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase G 3
  • Peptidyl-Prolyl Isomerase G 4
  • SCAF10 3
  • CYP 3

External Ids for PPIG Gene

Previous GeneCards Identifiers for PPIG Gene

  • GC02P168492
  • GC02P168982
  • GC02P170404
  • GC02P170643
  • GC02P170266
  • GC02P170150
  • GC02P162331

Summaries for PPIG Gene

GeneCards Summary for PPIG Gene

PPIG (Peptidylprolyl Isomerase G (Cyclophilin G)) is a Protein Coding gene. Diseases associated with PPIG include chronic venous insufficiency and venous insufficiency. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPID.

UniProtKB/Swiss-Prot for PPIG Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing

Gene Wiki entry for PPIG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIG Gene

Genomics for PPIG Gene

Regulatory Elements for PPIG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIG Gene

Start:
169,584,340 bp from pter
End:
169,641,406 bp from pter
Size:
57,067 bases
Orientation:
Plus strand

Genomic View for PPIG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIG Gene

Proteins for PPIG Gene

  • Protein details for PPIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13427-PPIG_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase G
    Protein Accession:
    Q13427
    Secondary Accessions:
    • D3DPC5
    • D3DPC6
    • O00706
    • Q53R40
    • Q53SN4
    • Q96DG9

    Protein attributes for PPIG Gene

    Size:
    754 amino acids
    Molecular mass:
    88617 Da
    Quaternary structure:
    • Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

    Three dimensional structures from OCA and Proteopedia for PPIG Gene

    Alternative splice isoforms for PPIG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIG Gene

Proteomics data for PPIG Gene at MOPED

Selected DME Specific Peptides for PPIG Gene

Post-translational modifications for PPIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPIG (PPIG)

Domains for PPIG Gene

Graphical View of Domain Structure for InterPro Entry

Q13427

UniProtKB/Swiss-Prot:

PPIG_HUMAN :
  • Q13427
Domain:
  • The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II
  • Contains 1 PPIase cyclophilin-type domain.
genes like me logo Genes that share domains with PPIG: view

No data available for Gene Families for PPIG Gene

Function for PPIG Gene

Molecular function for PPIG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation:
Cyclosporin A (CsA)-sensitive
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing

Enzyme Numbers (IUBMB) for PPIG Gene

Gene Ontology (GO) - Molecular Function for PPIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 21516116
GO:0016018 cyclosporin A binding TAS 9153302
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PPIG: view

miRNA for PPIG Gene

miRTarBase miRNAs that target PPIG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIG

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIG Gene

Localization for PPIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIG Gene

Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIG Gene COMPARTMENTS Subcellular localization image for PPIG gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
peroxisome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9153302
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016363 nuclear matrix IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PPIG: view

Pathways for PPIG Gene

genes like me logo Genes that share pathways with PPIG: view

Gene Ontology (GO) - Biological Process for PPIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
GO:0008380 RNA splicing TAS 9153302
genes like me logo Genes that share ontologies with PPIG: view

Compounds for PPIG Gene

(1) HMDB Compounds for PPIG Gene

Compound Synonyms Cas Number PubMed IDs
L-Proline
  • (-)-(S)-Proline
147-85-3

(1) Drugbank Compounds for PPIG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Proline
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target

(161) Novoseek inferred chemical compound relationships for PPIG Gene

Compound -log(P) Hits PubMed IDs
sulfaphenazole 91.2 14
furafylline 90.2 3
chlorzoxazone 89.8 22
troleandomycin 88 8
phenacetin 85.5 18
genes like me logo Genes that share compounds with PPIG: view

Transcripts for PPIG Gene

Unigene Clusters for PPIG Gene

Peptidylprolyl isomerase G (cyclophilin G):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIG Gene

No ASD Table

Relevant External Links for PPIG Gene

GeneLoc Exon Structure for
PPIG
ECgene alternative splicing isoforms for
PPIG

Expression for PPIG Gene

mRNA expression in normal human tissues for PPIG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PPIG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5), Testis (9.2), and Liver (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIG Gene

SOURCE GeneReport for Unigene cluster for PPIG Gene Hs.470544

mRNA Expression by UniProt/SwissProt for PPIG Gene

Q13427-PPIG_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PPIG: view

Expression partners for PPIG Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPIG Gene

Orthologs for PPIG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPIG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIG 35
  • 92.08 (n)
  • 94.56 (a)
PPIG 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIG 35
  • 94.15 (n)
  • 95.88 (a)
PPIG 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppig 35
  • 88.73 (n)
  • 92.54 (a)
Ppig 16
Ppig 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIG 35
  • 99.82 (n)
  • 99.87 (a)
PPIG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppig 35
  • 88.42 (n)
  • 91.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIG 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIG 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIG 35
  • 74.54 (n)
  • 74.9 (a)
PPIG 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIG 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12514 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4513 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18174 35
ppig 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Moca-cyp 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-8 37
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10778 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3359 36
  • 56 (a)
OneToMany
Species with no ortholog for PPIG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIG Gene

ENSEMBL:
Gene Tree for PPIG (if available)
TreeFam:
Gene Tree for PPIG (if available)

Paralogs for PPIG Gene

Paralogs for PPIG Gene

Pseudogenes.org Pseudogenes for PPIG Gene

genes like me logo Genes that share paralogs with PPIG: view

Variants for PPIG Gene

Sequence variations from dbSNP and Humsavar for PPIG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8207 - 169,637,353(+) AGGAC(A/G)ATGAA reference, missense
rs1050354 - 169,636,593(+) AAAGA(A/T)GACAA missense, reference
rs1060837 -- 169,621,776(+) CTTGT(A/G)TTAGG intron-variant
rs1111534 -- 169,603,581(+) TCTTA(C/T)ATGAT intron-variant
rs1345141 -- 169,639,505(+) GATTT(C/T)CAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPIG Gene

Variant ID Type Subtype PubMed ID
dgv4358n71 CNV Loss 21882294
dgv4359n71 CNV Loss 21882294
nsv518894 CNV Gain 19592680
esv2721115 CNV Deletion 23290073
esv2721116 CNV Deletion 23290073
nsv3025 CNV Loss 18451855
nsv834454 CNV Loss 17160897
nsv520764 CNV Loss 19592680

Relevant External Links for PPIG Gene

HapMap Linkage Disequilibrium report
PPIG
Human Gene Mutation Database (HGMD)
PPIG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIG Gene

Disorders for PPIG Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPIG Gene in MalaCards »

(4) Diseases for PPIG Gene including...

(5) University of Copenhagen DISEASES for PPIG Gene

(82) Novoseek inferred disease relationships for PPIG Gene

Disease -log(P) Hits PubMed IDs
chemical carcinogenesis 38.1 2
cancer 24.3 31
porphyria 18.9 1
liver diseases 15.1 5
liver dysfunction 12.3 2

Relevant External Links for PPIG

Genetic Association Database (GAD)
PPIG
Human Genome Epidemiology (HuGE) Navigator
PPIG
genes like me logo Genes that share disorders with PPIG: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PPIG Gene

Publications for PPIG Gene

  1. RS cyclophilins: identification of an NK-TR1-related cyclophilin. (PMID: 8973360) Nestel F.P. … Anderson S.K. (Gene 1996) 2 3 4
  2. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. (PMID: 9153302) Bourquin J.-P. … Schaffner W. (Nucleic Acids Res. 1997) 2 3 4
  3. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. (PMID: 15358154) Lin C.L. … Ouyang P. (Biochem. Biophys. Res. Commun. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for PPIG Gene

  • Addgene plasmids for PPIG

Sources for PPIG Gene

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