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PPIG Gene

protein-coding   GIFtS: 65
GCID: GC02P170404

Peptidylprolyl Isomerase G (Cyclophilin G)

(Previous name: peptidyl-prolyl isomerase G (cyclophilin G))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase G (Cyclophilin G)1 2     Clk-Associating RS-Cyclophilin2 3
Peptidyl-Prolyl Isomerase G (Cyclophilin G)1 2     PPIase G2 3
SR-Related CTD-Associated Factor 101 2     EC 5.2.1.83 8
Cyclophilin G2 3     CYP2
Rotamase G2 3     SCAF102
CARS-Cyp2 3     SRCyp2
CARS-cyclophilin2 3     Peptidyl-Prolyl Cis-Trans Isomerase G2
CASP102 3     SRcyp3
SR-cyclophilin2 3     Peptidyl-Prolyl Isomerase G3
SR-cyp2 3     

External Ids:    HGNC: 146501   Entrez Gene: 93602   Ensembl: ENSG000001383987   OMIM: 6060935   UniProtKB: Q134273   

Export aliases for PPIG gene to outside databases

Previous GC identifers: GC02P168492 GC02P168982 GC02P170643 GC02P170266 GC02P170150 GC02P162331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPIG Gene:
PPIG (peptidylprolyl isomerase G (cyclophilin G)) is a protein-coding gene. Diseases associated with PPIG include bladder disease, and proctitis. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is NKTR.

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play
an important role in the regulation of pre-mRNA splicing

summary for PPIG Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for PPIG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIG gene promoter:
         AhR   C/EBPbeta   Sp1   AP-1   ATF-2   Nkx2-5   c-Jun   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIG promoter sequence
   Search Chromatin IP Primers for PPIG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

PPIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170404:  view genomic region     (about GC identifiers)

Start:
170,440,850 bp from pter      End:
170,497,916 bp from pter
Size:
57,067 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase G  
Size: 754 amino acids; 88617 Da
Subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II
3 PDB 3D structures from and Proteopedia for PPIG:
2GW2 (3D)        2WFI (3D)        2WFJ (3D)    
Secondary accessions: D3DPC5 D3DPC6 O00706 Q53R40 Q53SN4 Q96DG9
Alternative splicing: 2 isoforms:  Q13427-1   Q13427-2   

Explore the universe of human proteins at neXtProt for PPIG: NX_Q13427

Explore proteomics data for PPIG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIG (Q13427) (see all 5)
     GGESIYG  LCTGEKG  PKTCENF  DKYKNKV 


    See PPIG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004783.2  
    ENSEMBL proteins: 
     ENSP00000260970   ENSP00000408683   ENSP00000386245   ENSP00000435987   ENSP00000407083  
     ENSP00000394202   ENSP00000402222   ENSP00000411643  

    PPIG Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PPIG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPIG
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    Novus Biologicals PPIG Proteins
    Novus Biologicals PPIG Lysate
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPIG
    Cloud-Clone Corp. Proteins for PPIG

    PPIG Antibody Products:

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    Novus Biologicals PPIG Antibodies
    Abcam antibodies for PPIG
    Cloud-Clone Corp. Antibodies for PPIG
    ThermoFisher Antibodies for PPIG
    LSBio Antibodies in human, mouse, rat for PPIG

    PPIG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PPIG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPIG
    Cloud-Clone Corp. CLIAs for PPIG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry Q13427

    ProtoNet protein and cluster: Q13427

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427
    Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase
    II
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIG_HUMAN, Q13427
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play
    an important role in the regulation of pre-mRNA splicing
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA)-sensitive

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding IPI--
    GO:0016018cyclosporin A binding TAS9153302
    GO:0044822poly(A) RNA binding IDA--
         
    PPIG for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPIG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIG

    miRNA
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    miRTarBase miRNAs that target PPIG:
    hsa-let-7e-5p (MIRT051505)

    Block miRNA regulation of human, mouse, rat PPIG using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PPIG:
    hsa-miR-374b* hsa-miR-548a-3p hsa-miR-4274 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidPPIG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPIG
    Predesigned siRNA for gene silencing in human, mouse, rat PPIG

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIG (NM_004792)
    Sino Biological Human cDNA Clone for PPIG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIG

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PPIG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIG_HUMAN, Q13427: Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear
    speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS9153302
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016363nuclear matrix IEA--

    PPIG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPIG About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPIG (see all 16)
        Caspase Cascade
    S-1P Stimulated Signaling
    14-3-3 Induced Apoptosis
    DHA Signaling
    Endothelin-1 Signaling Pathway

    1 Cell Signaling Technology (CST) Pathway for PPIG
        Translational Control

    2 Tocris Bioscience Pathways for PPIG
        Apoptosis Pathway
    VEGF Pathway




    PPIG for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIG
    Interactions:

        GeneGlobe Interaction Network for PPIG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPIG (Q134271, 2, 3 ENSP000002609704) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153651, 2, ENSP000003055564EBI-396072,EBI-946095 MINT-8332119 MINT-8338080 STRING: ENSP00000305556
    YWHAGP619812, 3, ENSP000003063304MINT-50844 I2D: score=4 STRING: ENSP00000306330
    PNNQ9H3073, ENSP000002168324I2D: score=3 STRING: ENSP00000216832
    CLK1P497593, ENSP000003268304I2D: score=2 STRING: ENSP00000326830
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0008380RNA splicing TAS9153302

    PPIG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPIG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    1 HMDB Compound for PPIG    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    1 DrugBank Compound for PPIG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PPIG gene (see all 161)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfaphenazole 91.2 16 10077440 (2), 8267647 (1), 8654202 (1), 16875977 (1) (see all 13)
    furafylline 90.2 3 11136295 (1), 20081260 (1), 12399157 (1)
    chlorzoxazone 89.8 26 10534312 (2), 8053924 (1), 10589936 (1), 10510277 (1) (see all 21)
    troleandomycin 88 10 19616568 (1), 8267647 (1), 8735469 (1), 10661723 (1) (see all 8)
    phenacetin 85.5 19 10548449 (2), 10901704 (1), 10917566 (1), 10805063 (1) (see all 17)
    ketoconazole 85.2 18 8053924 (2), 10598746 (1), 11136295 (1), 19302901 (1) (see all 16)
    bufuralol 84.8 9 11523064 (1), 15618695 (1), 10805063 (1), 11037108 (1) (see all 9)
    ethoxyresorufin 83.5 17 9464470 (1), 10917566 (1), 11523064 (1), 16615094 (1) (see all 17)
    alpha-naphthoflavone 82.5 6 8267647 (1), 8654202 (1), 11640917 (1), 12514286 (1) (see all 5)
    tolbutamide 82 21 14749695 (2), 8053924 (1), 9522439 (1), 10901704 (1) (see all 19)



    PPIG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPIG gene: 
    NM_004792.2  

    Unigene Cluster for PPIG:

    Peptidylprolyl isomerase G (cyclophilin G)
    Hs.470544  [show with all ESTs]
    Unigene Representative Sequence: U40763
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260970(uc002uez.3 uc010fpx.3 uc010fpy.3 uc002ufb.3 uc002ufd.3)
    ENST00000433207 ENST00000409714 ENST00000530152 ENST00000462903(uc002ufa.3)
    ENST00000448752 ENST00000418888 ENST00000414307(uc002ufc.1) ENST00000417938
    ENST00000482772 ENST00000466142
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate PPIG:
    hsa-miR-374b* hsa-miR-548a-3p hsa-miR-4274 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidPPIG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPIG
    Predesigned siRNA for gene silencing in human, mouse, rat PPIG
    Clone
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    OriGene clones in human, mouse for PPIG (see all 7)
    OriGene ORF clones in mouse, rat for PPIG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIG (NM_004792)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIG
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIG
      QuantiTect SYBR Green Assays in human, mouse, rat PPIG
      QuantiFast Probe-based Assays in human, mouse, rat PPIG

    Additional mRNA sequence: 

    AK307552.1 BC001555.1 BC063711.1 BC073875.1 BC109373.1 BC111693.1 U40763.1 X99717.1 

    22 DOTS entries:

    DT.80100810  DT.95313139  DT.40298763  DT.95151215  DT.99974500  DT.92353152  DT.121009925  DT.121009922 
    DT.92440961  DT.101972912  DT.100030664  DT.121009903  DT.121009951  DT.426676  DT.91647489  DT.91808753 
    DT.95167383  DT.100033355  DT.102841402  DT.40200055  DT.91698421  DT.95112363 

    Selected AceView cDNA sequences (see all 466):

    BX114273 BE501074 AA287302 BG152898 T25029 AA760748 BQ880972 BU633278 
    CA418130 BP347343 BG112380 CD242982 CB242256 CD366590 BQ772365 AA458502 
    NM_004792 BM463543 BM930833 AI271927 BU786268 AU135498 BU627781 F13062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAAACAA
    PPIG Expression
    About this image


    PPIG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PPIG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470544

    UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for PPIG
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    QuantiTect SYBR Green Assays in human, mouse, rat PPIG
    QuantiFast Probe-based Assays in human, mouse, rat PPIG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPIG gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppig1 , 5 peptidyl-prolyl isomerase G (cyclophilin G)1, 5 88.73(n)1
    92.54(a)1
      2 (40.95 cM)5
    2280051  NM_001081086.11  NP_001074555.11 
     697225455 
    chicken
    (Gallus gallus)
    Aves PPIG1 peptidylprolyl isomerase G (cyclophilin G) 74.54(n)
    74.9(a)
      424162  XM_004942752.1  XP_004942809.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPIG6
    peptidylprolyl isomerase G (cyclophilin G)
    73(a)
    1 ↔ 1
    GL343362.1(475506-495659)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45132 Xenopus laevis transcribed sequence with moderate similarity more 80.15(n)    BU910998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.181742 Danio rerio mRNA similar to matrin cyclophilin (matrin-cyp) more 72.73(n)    BC044189.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Moca-cyp6
    Moca-cyp
    25(a)
    1 → many
    3R(24166060-24170891)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR66
    Peptidyl-prolyl cis-trans isomerase (cyclophilin),...
    34(a)
    1 → many
    XII(572096-573211) YLR216C


    ENSEMBL Gene Tree for PPIG (if available)
    TreeFam Gene Tree for PPIG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIG gene
    NKTR2  PPID2  PPIL62  
    Selected SIMAP similar genes for PPIG using alignment to 10 protein entries:     PPIG_HUMAN (see all proteins) (see all similar genes):
    DKFZp686G0426    NKTR    PPID    PPIL6    PPIB    RANBP2
    PPIC    PPIF    PPIE    PPWD1    PPIH    PPIA
    PPIL3    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G    PPIAL4D

    PPIG for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPIG
    PGOHUM00000235819


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PPIG (see all 1283)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883632371,2
    --170438868(+) AACTAC/TAGGAT 1 -- us2k10--------
    rs1494810531,2
    C--170438877(+) ATAAC-/AAATGTT 1 -- us2k10--------
    rs1459008291,2
    C--170438933(+) TTTTA-/TT    
       TAACT
    TTTAA
    1 -- us2k10--------
    rs1181380061,2
    C,F--170439011(+) TATTTC/TATCAC 1 -- us2k11Minor allele frequency- T:0.07EA 120
    rs796188301,2
    C--170439091(+) TGATAG/CGCCCC 1 -- us2k14Minor allele frequency- C:0.12WA NA EA 360
    rs1150426101,2
    C,F--170439106(+) TGTATT/CGTGCC 1 -- us2k13Minor allele frequency- C:0.42WA NA EA 358
    rs1810017171,2
    --170439120(+) CTATGC/TCTTCA 1 -- us2k10--------
    rs794050731,2
    C--170439313(+) TATCAA/CGTCTA 1 -- us2k10--------
    rs1858797881,2
    --170439384(+) ACATAC/TATATG 1 -- us2k10--------
    rs1397757391,2
    --170439406(+) ATAACA/CGAACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIG (170440850 - 170497916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PPIG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721116CNV Deletion23290073
    esv2721115CNV Deletion23290073
    nsv520764CNV Loss19592680
    nsv3025CNV Loss18451855
    nsv834454CNV Loss17160897
    dgv4358n71CNV Loss21882294
    dgv4359n71CNV Loss21882294
    nsv518894CNV Gain19592680

    Human Gene Mutation Database (HGMD): PPIG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIG
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606093    OMIM disorders: --

    Selected diseases for PPIG (see all 68):    
    About MalaCards
    bladder disease    proctitis    myocardial infarction    venous insufficiency
    liver disease    barrett's esophagus    porphyria    pulmonary disease, chronic obstructive
    hypertriglyceridemia    adrenocortical carcinoma    alzheimer's disease    cystitis
    primary hyperparathyroidism    myelodysplastic syndromes    hyperglycemia    sepsis
    endometriosis    severe combined immunodeficiency    coronary artery disease    influenza

    5 diseases from the University of Copenhagen DISEASES database for PPIG:
    Liver disease     Heart disease     Breast cancer     Lung cancer
    Hypertension

    PPIG for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PPIG gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chemical carcinogenesis 38.1 2 9486585 (1), 19858070 (1)
    cancer 24.3 36 15828850 (2), 9255558 (2), 10667460 (2), 15180491 (2) (see all 27)
    porphyria 18.9 1 10964007 (1)
    liver diseases 15.1 6 19533803 (1), 10589374 (1), 12569554 (1), 8672739 (1) (see all 5)
    liver dysfunction 12.3 2 12867215 (1), 15753745 (1)
    rhabdomyolysis 9.89 1 11936570 (1)
    cancer lung 9.18 3 7620940 (1), 17127240 (1), 9364212 (1)
    psychiatric disorder 5.43 1 9579322 (1)
    hyperglycemia 5.24 1 10522495 (1)
    adenoma 5.12 1 16281975 (1)

    Genetic Association Database (GAD): PPIG
    Human Genome Epidemiology (HuGE) Navigator: PPIG (1 document)

    Export disorders for PPIG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIG gene, integrated from 10 sources (see all 860):
    (articles sorted by number of sources associating them with PPIG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. (PubMed id 9153302)1, 2, 3 Bourquin J.-P.... Schaffner W. (Nucleic Acids Res. 1997)
    2. RS cyclophilins: identification of an NK-TR1-related cyclophilin. (PubMed id 8973360)1, 2, 3 Nestel F.P.... Anderson S.K. (Gene 1996)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. (PubMed id 15358154)1, 2 Lin C.L.... Ouyang P. (Biochem. Biophys. Res. Commun. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    9. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    10. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9360 HGNC: 14650 AceView: PPIG Ensembl:ENSG00000138398 euGenes: HUgn9360
    ECgene: PPIG H-InvDB: PPIG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPIG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPIG gene:
    Search GeneIP for patents involving PPIG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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