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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPIG Gene

protein-coding GIFtS: 61
GCID: GC02P170404

peptidylprolyl isomerase G (cyclophilin G)

(Previous name: peptidyl-prolyl isomerase G (cyclophilin G) )

Explore 71 diseases affiliated with
PPIG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase G (Cyclophilin G)¹ ²		SR-Cyp¹
CARS-Cyp¹ ² ³		Clk-Associating RS-Cyclophilin² ³
SCAF10¹ ²		PPIase G² ³
SRCyp¹ ²		EC 5.2.1.8³ ⁸
Peptidyl-Prolyl Isomerase G (Cyclophilin G)¹ ²		CYP²
Cyclophilin G² ³		Peptidyl-Prolyl Cis-Trans Isomerase G²
Rotamase G² ³		SR-Related CTD-Associated Factor 10²
CARS-Cyclophilin¹		SRcyp³
CASP10² ³		Peptidyl-Prolyl Isomerase G³
SR-Cyclophilin¹

External Ids:	HGNC: 14650¹	Entrez Gene: 9360²	Ensembl: ENSG00000138398⁷	OMIM: 606093⁵	UniProtKB: Q13427³

Export aliases for PPIG gene to outside databases

Previous GC identifers: GC02P168492 GC02P168982 GC02P170643 GC02P170266 GC02P170150 GC02P162331

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an

important role in the regulation of pre-mRNA splicing

summary for PPIG:

Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of

apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and

effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,

upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector

caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the

executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase

Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors

such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For

example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form

part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by

inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of

many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory

disease.

Gene Wiki entry for PPIG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPIG gene promoter:
AhR C/EBPbeta Sp1 AP-1 ATF-2 Nkx2-5 c-Jun Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPIG promoter sequence

Search SABiosciences Chromatin IP Primers for PPIG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1

PPIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIG gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P170404: view genomic region (about GC identifiers)

Start:	170,440,850 bp from pter	End:	170,497,916 bp from pter
Size:	57,067 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase G

Size: 754 amino acids; 88617 Da

Subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II

Subcellular location: Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles

3 PDB 3D structures from and Proteopedia for PPIG:

2GW2 (3D)

2WFI (3D)

2WFJ (3D)

Secondary accessions: D3DPC5 D3DPC6 O00706 Q53R40 Q53SN4 Q96DG9

Alternative splicing: 2 isoforms: Q13427-1 Q13427-2

Explore the universe of human proteins at neXtProt for PPIG: NX_Q13427

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13427

4/5 DME Specific Peptides for PPIG (Q13427) (see all 5)

GGESIYG

LCTGEKG

PKTCENF

DKYKNKV

PPIG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004783.2

ENSEMBL proteins:

ENSP00000260970 ENSP00000408683 ENSP00000386245 ENSP00000435987 ENSP00000407083

ENSP00000394202 ENSP00000402222 ENSP00000411643

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for PPIG
	Uscn Proteins for PPIG

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	9153302
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0016363	nuclear matrix	IEA	--

PPIG for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PPIG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPIG for domains About GeneDecksing

2 InterPro domains/families:

IPR002130 Cyclophilin-like_PPIase_dom

IPR020892 Cyclophilin-type_PPIase_CS

Graphical View of Domain Structure for InterPro Entry Q13427

ProtoNet protein and cluster: Q13427

1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427

Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II

Similarity: Contains 1 PPIase cyclophilin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an

important role in the regulation of pre-mRNA splicing

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme regulation: Cyclosporin A (CsA)-sensitive

Enzyme Number (IUBMB): EC 5.2.1.8¹ ²

miRNA Products:		OriGene 3'-UTR Clone: PPIG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIG
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		hsa-miR-374b* hsa-miR-548a-3p hsa-miR-4274 hsa-miR-548e
		SwitchGear 3'UTR luciferase reporter plasmid: PPIG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIG (see all 7) OriGene shRNA RFP: PPIG OriGene siRNA: PPIG
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPIG
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIG

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA	--
GO:0016018	cyclosporin A binding	TAS	9153302

PPIG for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translational Control

Translational Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for PPIG

Translational Control

2 Tocris Bioscience Pathways for PPIG

	Apoptosis Pathway
	VEGF Pathway

PPIG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPIG

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/20 Interacting proteins for PPIG (Q13427^{2, 3} ENSP00000260970⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-50844 I2D: score=4 STRING: ENSP00000306330
PCBP1	Q15365², ENSP00000305556⁴	MINT-8332119 MINT-8338080 STRING: ENSP00000305556
PNN	Q9H307³, ENSP00000216832⁴	I2D: score=3 STRING: ENSP00000216832
CLK1	P49759³, ENSP00000326830⁴	I2D: score=2 STRING: ENSP00000326830
POLR2A	P24928³, ENSP00000314949⁴	I2D: score=2 STRING: ENSP00000314949

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IEA	--
GO:0008380	RNA splicing	TAS	9153302

PPIG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPIG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PPIG available from Tocris Bioscience About this table

Compound	Action	CAS #
Ac-LEHD-AFC	Fluorogenic caspase substrate	[210345-03-2]
Z-VAD-FMK	Cell-permeable, irreversible caspase inhibitor	--

1 HMDB Compound for PPIG About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Proline	(-)-(S)-Proline (see all 16)	147-85-3	--

1 DrugBank Compound for PPIG About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Proline	(-)-2-Pyrrolidinecarboxylic acid (see all 6)	147-85-3	target	--	17139284 17016423

10/161 Novoseek chemical compound relationships for PPIG gene (see all 161) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sulfaphenazole	91.2	16	10077440 (2), 8267647 (1), 8654202 (1), 16875977 (1) (see all 13)
furafylline	90.2	3	11136295 (1), 20081260 (1), 12399157 (1)
chlorzoxazone	89.8	26	10534312 (2), 8053924 (1), 10589936 (1), 10510277 (1) (see all 21)
troleandomycin	88	10	19616568 (1), 8267647 (1), 8735469 (1), 10661723 (1) (see all 8)
phenacetin	85.5	19	10548449 (2), 10901704 (1), 10917566 (1), 10805063 (1) (see all 17)
ketoconazole	85.2	18	8053924 (2), 10598746 (1), 11136295 (1), 19302901 (1) (see all 16)
bufuralol	84.8	9	11523064 (1), 15618695 (1), 10805063 (1), 11037108 (1) (see all 9)
ethoxyresorufin	83.5	17	9464470 (1), 10917566 (1), 11523064 (1), 16615094 (1) (see all 17)
alpha-naphthoflavone	82.5	6	8267647 (1), 8654202 (1), 11640917 (1), 12514286 (1) (see all 5)
tolbutamide	82	21	14749695 (2), 8053924 (1), 9522439 (1), 10901704 (1) (see all 19)

Search CenterWatch for drugs/clinical trials and news about PPIG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPIG gene:

NM_004792.2

Unigene Cluster for PPIG:

Peptidylprolyl isomerase G (cyclophilin G)

Hs.727580 [show with all ESTs]

Unigene Representative Sequence: U40763

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000260970(uc002uez.3 uc010fpx.3 uc010fpy.3 uc002ufb.3 uc002ufd.3)

ENST00000433207 ENST00000409714 ENST00000530152 ENST00000462903(uc002ufa.3)

ENST00000448752 ENST00000418888 ENST00000414307(uc002ufc.1) ENST00000417938

ENST00000482772 ENST00000466142

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		hsa-miR-374b* hsa-miR-548a-3p hsa-miR-4274 hsa-miR-548e
		SwitchGear 3'UTR luciferase reporter plasmid: PPIG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PPIG (NM_004792)
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Additional cDNA sequence:

AK307552.1 BC001555.1 BC063711.1 BC073875.1 BC109373.1 BC111693.1 U40763.1 X99717.1

20 DOTS entries:

DT.80100810 DT.95313139 DT.40298763 DT.95151215 DT.99974500 DT.92353152 DT.121009925 DT.121009922

DT.92440961 DT.101972912 DT.121009903 DT.121009951 DT.426676 DT.91647489 DT.91808753 DT.95167383

DT.100030664 DT.100033355 DT.40200055 DT.95112363

24/466 AceView cDNA sequences (see all 466):

AA495740 BU675131 AI244752 CA418130 BQ880972 CA952480 CD244516 BX114273

BP375607 CB306063 AA380116 AI919249 BM968932 AA458502 AL700290 BU786268

BM794950 CB242256 AI298944 AK124958 BM512518 BM463543 BM930833 BU077636

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPIG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAAACAA

About this image
See PPIG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIG

SOURCE GeneReport for Unigene cluster: Hs.727580

UniProtKB/Swiss-Prot: PPIG_HUMAN, Q13427

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for PPIG

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIG gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPIG¹	peptidylprolyl isomerase G (cyclophilin G)	77.51(n) 78.09(a)		424162 XM_422008.3 XP_422008.1
lizard (Anolis carolinensis)	Reptilia	PPIG⁶	--	73(a)	1 ↔ 1	GL343362.1(475524-495659)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4513²	Xenopus laevis transcribed sequence with moderate similarity more	80.15(n)		BU910998.1
zebrafish (Danio rerio)	Actinopterygii	Dr.18174²	Danio rerio mRNA similar to matrin cyclophilin (matrin-cyp) more	72.73(n)		BC044189.1
fruit fly (Drosophila melanogaster)	Insecta	CG8336⁶	--	23(a)	possible ortholog	3L(9621776-9624895)
worm (Caenorhabditis elegans)	Secernentea	cyp-8³ cyn-8¹	Expression: intestine, pharynx, embryo, L1 larva, more³ Protein CYN-8¹	57(a)³ 44.47(n)¹ 36.32(a)¹		X(8946628-8949076)³ 181136¹ NM_077105.3¹ NP_509506.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G22920⁶ AT3G63400⁶ (see all 3)	peptidylprolyl isomerase cyclophilin-like peptidyl-prolyl cis-trans isomera... (see all 3)	32(a) 24(a) (see all 3)	possible ortholog many ↔ many (see all 3)	3(8122713-8123411) 3(23412024-23415659)
rice (Oryza sativa)	Liliopsida	--	peptidyl-prolyl cis-trans isomerase, putative, exp...	30(a)	1 → many	2(5826295-5834386)

ENSEMBL Gene Tree for PPIG (if available)
TreeFam Gene Tree for PPIG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPIG gene

NKTR² PPID² PPIL6²

18/22 SIMAP similar genes for PPIG using alignment to 10 protein entries: PPIG_HUMAN (see all proteins) (see all similar genes):

DKFZp686G0426 NKTR PPID PPIL6 PPIB RANBP2

PPIC PPWD1 PPIE PPIH PPIA PPIF

PPIL3 PPIAL4A PPIAL4B PPIAL4C PPIAL4G LOC402252

PPIG for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PPIG
PGOHUM00000235819

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188363237^1,2		--	170438868(+)	`AACTAC/TAGGAT`	1	--	us2k¹		0	--	--	--	--
rs149481053^1,2		--	170438877(+)	`ATAAC-/AAATGTT`	1	--	us2k¹		0	--	--	--	--
rs145900829^1,2	C,	--	170438933(+)	`TTTTA-/TT TAACTTTTAA`	1	--	us2k¹		0	--	--	--	--
rs118138006^1,2	F,	--	170439011(+)	`TATTTC/TATCAC`	1	--	us2k¹		1		EA	120
rs79618830^1,2	C,	--	170439091(+)	`TGATAG/CGCCCC`	1	--	us2k¹		4		WA NA EA	360
rs115042610^1,2	C,F,	--	170439106(+)	`TGTATT/CGTGCC`	1	--	us2k¹		3		WA NA EA	358
rs181001717^1,2		--	170439120(+)	`CTATGC/TCTTCA`	1	--	us2k¹		0	--	--	--	--
rs79405073^1,2	C,	--	170439313(+)	`TATCAA/CGTCTA`	1	--	us2k¹		0	--	--	--	--
rs185879788^1,2		--	170439384(+)	`ACATAC/TATATG`	1	--	us2k¹		0	--	--	--	--
rs139775739^1,2		--	170439406(+)	`ATAACA/CGAACA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPIG (170440850 - 170497916 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PPIG
2 CNVs: 35759 50331
Human Gene Mutation Database (HGMD): PPIG

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPIG for disorders           About GeneDecksing

OMIM gene information: 606093    OMIM disorders: --

20/71 diseases for PPIG (see all 71):    About MalaCards

venous insufficiency non-small cell lung carcinoma barrett's esophagus severe combined immunodeficiency

autism spectrum disorder chronic obstructive pulmonary disease combined immunodeficiency myocardial infarction

fatty liver disease liver disease porphyria esophageal squamous cell carcinoma

squamous cell carcinoma coronary heart disease myelodysplastic syndrome proctitis

hypertriglyceridemia macular degeneration pulmonary disease hepatitis c

5 diseases from the University of Copenhagen DISEASES database for PPIG:

Liver disease Breast cancer Heart disease Lung cancer

Hypertension

10/82 Novoseek disease relationships for PPIG gene (see all 82) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chemical carcinogenesis	38.1	2	9486585 (1), 19858070 (1)
cancer	24.3	36	15828850 (2), 9255558 (2), 10667460 (2), 15180491 (2) (see all 27)
porphyria	18.9	1	10964007 (1)
liver diseases	15.1	6	19533803 (1), 10589374 (1), 12569554 (1), 8672739 (1) (see all 5)
liver dysfunction	12.3	2	12867215 (1), 15753745 (1)
rhabdomyolysis	9.89	1	11936570 (1)
cancer lung	9.18	3	7620940 (1), 17127240 (1), 9364212 (1)
psychiatric disorder	5.43	1	9579322 (1)
hyperglycemia	5.24	1	10522495 (1)
adenoma	5.12	1	16281975 (1)

Human Genome Epidemiology (HuGE) Navigator: PPIG (1 document)

Export disorders for PPIG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPIG gene, integrated from 9 sources (see all 856):
(articles sorted by number of sources associating them with PPIG)

Utopia: connect your pdf to the dynamic
world of online information

A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. (PubMed id 9153302)^{1, 2, 3} Bourquin J.-P.... Schaffner W. (1997)
RS cyclophilins: identification of an NK-TR1-related cyclophilin. (PubMed id 8973360)^{1, 2, 3} Nestel F.P.... Anderson S.K. (1996)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. (PubMed id 15358154)^{1, 2} Lin C.L.... Ouyang P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9360	HGNC: 14650	AceView: PPIG	Ensembl:ENSG00000138398	euGenes: HUgn9360
ECgene: PPIG	H-InvDB: PPIG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPIG	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PPIG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PPIG gene:
Search GeneIP for patents involving PPIG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PPIG Gene

peptidylprolyl isomerase G (cyclophilin G)

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PPIG (Gene Symbol)
Peptidylprolyl Isomerase G (Cyclophilin G)
CARS-Cyp
SCAF10
SRCyp
Peptidyl-Prolyl Isomerase G (Cyclophilin G)
Cyclophilin G
Rotamase G
CARS-Cyclophilin
CASP10
SR-Cyclophilin
SR-Cyp
Clk-Associating RS-Cyclophilin
PPIase G
EC 5.2.1.8
CYP
Peptidyl-Prolyl Cis-Trans Isomerase G
SR-Related CTD-Associated Factor 10
SRcyp
Peptidyl-Prolyl Isomerase G

Fatty Liver
Porphyria
Hepatic Necrosis
Genetic Susceptibility
sepsis
Endometriosis
Rhabdomyolysis
Allergic Reaction
aggressiveness
Atherosclerosis
Ischemia
Liver diseases
Metaplasia
Breast Cancer
NSCLC
primary tumor
Schizophrenia
AIDS
Adenocarcinoma
Neck Cancer
Cancer
Lymphoma
GASTRIC CARCINOMA
RENAL DISEASE
Shock
Chronic venous insufficiency
Epilepsy
Colorectal Cancer
Malnutrition
Inflammation
Tuberculosis
chemical carcinogenesis
Arrhythmia
Hyperglycemia
Hepatitis B
Hypertrophy
psychiatric disorder
Pulmonary Disease Chronic Obstructive
LIVER DAMAGE
prostate cancer
Tumors
Cardiovascular Diseases
Metastasis
Necrosis
SMOKING HABIT
virus infection
Hepatitis C
Barrett Esophagus
Myeloid Leukemia
Cirrhosis
Autoimmune Diseases
Melanoma
BREAST CARCINOMA
bladder cancer
Critically Ill
Carcinoma
Infectious disease
Leukemia
Alzheimers Disease
Diabetes Mellitus
HEPATOCELLULAR CARCINOMA
Effects Cardiovascular
Myopathy
Lymphoma Lymphoblastic
Cancer Lung
chronic pancreatitis
Myocardial Infarction
HEART FAILURE
Influenza
Coronary Artery Disease
Response Acute Phase
Heart Diseases
Ascites
Liver Dysfunction
Adenoma
Bleeding
Hypertriglyceridemia
OBESITY
STROKE
chronic liver disease
Myelodysplastic Syndromes
Renal Failure Chronic

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PPIG Gene

peptidylprolyl isomerase G (cyclophilin G)

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