PPIF Gene
protein-coding GIFtS: 65
GCID: GC10P081107
|
|
peptidylprolyl isomerase F(Previous name: peptidylprolyl isomerase F (cyclophilin F) )
| |
Aliases
for PPIF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peptidylprolyl Isomerase F1 2 | | Peptidylprolyl Isomerase F (Cyclophilin F)1 | | CYP32 3 5 | | Cyclophilin 32 | | Cyp-D1 2 | | Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial2 | | Cyclophilin D2 3 | | Peptidyl-Prolyl Cis-Trans Isomerase, Mitochondrial2 | | Cyclophilin F2 3 | | CyP-D3 | | Rotamase F2 3 | | CyP-M3 | | PPIase F2 3 | | CypD3 | | EC 5.2.1.83 8 | | Mitochondrial Cyclophilin3 | | HCyP31 | | |
Export aliases for PPIF gene to outside databasesPrevious GC identifers: GC10P080064 GC10P080316 GC10P080999 GC10P080451 GC10P080777 GC10P075101 |
Summaries
for PPIF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPIF:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIasescatalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding ofproteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane.Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It isproposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) andpromotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity forthis function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-inducednecrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation ofmitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperationwith BCL2 inhibits cytochrome c-dependent apoptosis
Gene Wiki entry for PPIF
|
Genomic Views
for PPIF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPIF gene promoter:
RORalpha1 CREB E2F-1 E2F Sp1 Lmo2 CUTL1 Arnt ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPIF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22-q23 Ensembl cytogenetic band: 10q22.3 HGNC cytogenetic band: 10q22-q23PPIF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P081107: view genomic region
(about GC identifiers)
Start:
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81,107,220 bp from pter |
End:
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81,115,093 bp from pter |
Size:
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7,874 bases |
Orientation:
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plus strand |
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Proteins
for PPIF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor Size: 207 amino acids; 22040 Da
Subunit: Believed to associate with the mitochondrial permeability transition pore complex (PTPC). Associates with themitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic phosphate (Pi)and decreased by cyclosporin A (CsA). Interacts with ATP5B; ATP5H and ATP5O. Interacts with SLC25A3; the interactionis impaired by CsA. Interacts with BCL2; the interaction is impaired by CsA. Interacts with TP53; the associationimplicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA. Interacts with C1QBP
Subcellular location: Mitochondrion matrix
6/19 PDB 3D structures from  and Proteopedia  for PPIF (see all 19):2BIT (3D)
2BIU (3D)
2Z6W (3D)
3QYU (3D)
3R49 (3D)
3R4G (3D)
Secondary accessions: Q5W131Explore the universe of human proteins at neXtProt for PPIF: NX_P30405
Post-translational modifications:
Deacteylated at Lys-167 by SIRT3 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P30405
4/17 DME Specific Peptides for PPIF (P30405) (see all 17)
PPIF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005720.1
ENSEMBL proteins: ENSP00000225174 ENSP00000396388 ENSP00000378080
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005624 | membrane fraction |
-- | -- | | GO:0005739 | mitochondrion |
-- | -- | | GO:0005743 | mitochondrial inner membrane |
-- | -- | | GO:0005753 | colocalizes with mitochondrial proton-transporting ATP synthase complex |
ISS | -- | | GO:0005759 | mitochondrial matrix |
IEA | -- |
PPIF for ontologies About GeneDecksing
PPIF Antibody Products:
Assay Products for PPIF: |
Protein
Domains /
Families
for PPIF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPIF for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P30405ProtoNet protein and cluster: P30405 1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase
UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405Similarity: Belongs to the cyclophilin-type PPIase familySimilarity: Contains 1 PPIase cyclophilin-type domain |
Function
for PPIF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It isproposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) andpromotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity forthis function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-inducednecrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation ofmitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperationwith BCL2 inhibits cytochrome c-dependent apoptosisCatalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme regulation: Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probablity ofthe mPTPEnzyme Number (IUBMB): EC 5.2.1.81 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPIF (NM_005729) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIF |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PPIF for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PPIF:
Animal Models:
Mouse knock-outs for PPIF: Ppiftm1Tsu Ppiftm1.1Mmos Ppiftm1Maf Ppiftm1Jmol
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ppif):
PPIF for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPIF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Leishmaniasis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for PPIF):
PPIF for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIF
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/168 Interacting proteins for PPIF (P304051, 3 ENSP000002251744) via UniProtKB, MINT, STRING, and/or I2D (see all 168)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000413 | protein peptidyl-prolyl isomerization |
-- | -- | | GO:0002931 | response to ischemia |
ISS | -- | | GO:0006457 | protein folding |
IEA | -- | | GO:0008637 | apoptotic mitochondrial changes |
IEA | -- | | GO:0010849 | regulation of proton-transporting ATPase activity, rotational mechanism |
ISS | -- |
PPIF for ontologies About GeneDecksing
|
Drugs & Compounds
for PPIF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PPIF
2 HMDB Compounds for PPIF About this table
3 DrugBank Compounds for PPIF About this table
Search CenterWatch for drugs/clinical trials and news about PPIF
|
Transcripts
for PPIF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPIF gene: NM_005729.3 Unigene Cluster for PPIF: Peptidylprolyl isomerase F Hs.381072 [show with all ESTs]Unigene Representative Sequence: NM_0057296 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000498681 ENST00000225174(uc001kai.3 uc001kaj.3) ENST00000472580
ENST00000492149 ENST00000448165 ENST00000394579
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPIF (NM_005729) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIF |
Additional cDNA sequence: AK296669.1 AK312757.1 BC005020.1 BC013204.1 BC110299.1 M80254.1 19 DOTS entries: DT.447469 DT.100726706 DT.95168936 DT.100885193 DT.100885205 DT.100030764 DT.100885214 DT.121267742 DT.121267754 DT.100885190 DT.100885197 DT.101965040 DT.121267728 DT.95168938 DT.100885200 DT.100885201 DT.100885212 DT.40132562 DT.100885198 24/594 AceView cDNA sequences (see all 594): CB111757 AW769238 AI343788 BM758570 CR595750 T33968 BM905141 BX341101 BG171201 CB131161 N20355 BU626696 BQ676697 H65952 CB159053 BM784315 CF264913 CR596778 BM844859 BC005020 AW009430 CB107160 AV706047 CR601435
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPIF (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for PPIF
|
Expression
for PPIF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPIF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTGTGTT
About this image
See PPIF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIF
SOURCE GeneReport for Unigene cluster: Hs.381072
SABiosciences Custom PCR Arrays for PPIF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPIF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIF |
Orthologs
for PPIF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPIF gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPIF1 |
peptidylprolyl isomerase F |
72.64(n)
83.08(a) |
|
423723 NM_001031226.1 NP_001026397.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PPIF6 |
-- |
78(a) |
1 ↔ 1 |
GL343468.1(591051-606393) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
MGC757152 |
hypothetical protein MGC75715 |
76.44(n) |
|
BC059741.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.268272 |
Transcribed sequence with moderate similarity to protein more |
76.55(n) |
|
CK361200.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cyp11 , 3 |
protein folding cyclin-dependent protein
kinase, more3
Cyclophilin 11 |
77(a)
(best of 3)3
68.14(n)1
72.38(a)1 |
|
14B123
325951 NM_078642.31 NP_523366.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
cyp-33 |
Peptidyl-prolyl cis-trans isomerases |
68(a)
(best of 2) |
|
V(15192351-15193440) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CPR1(YDR155C)4
CPR11 |
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), more4
Cpr1p1 |
64.57(n)1
70.44(a)1 |
|
4(769000-768512)4
8517331, 4 NP_010439.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CYP20-21 |
Peptidyl-prolyl cis-trans isomerase CYP20-2 |
61.64(n)
72.33(a) |
|
831151 NM_001203370.1 NP_001190299.1 |
rice
(Oryza sativa) |
Liliopsida |
AK061894.12 |
-- |
78.5(n) |
|
AK061894.1 |
ENSEMBL Gene Tree for PPIF (if available)
TreeFam Gene Tree for PPIF (if available) |
Paralogs
for PPIF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPIF gene
- PPIE2 PPIAL4A2 PPIAL4C2 PPIAL4G2 PPIAL4B2 PPIA2 PPIAL4D2
18/22 SIMAP similar genes for PPIF using alignment to 3 protein entries: PPIF_HUMAN (see all proteins)
(see all similar genes):RANBP2 PPIA PPIE PPIAL4A PPIAL4B PPIAL4C
PPIAL4G LOC402252 PPIC PPID PPIH PPIB
PPWD1 NKTR PPIL6 PPIL1 DKFZp686G0426 PPIL3
PPIF for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for PPIF
PGOHUM00000259631 PGOHUM00000250443 PGOHUM00000250271 PGOHUM00000250965 PGOHUM00000236691
|
Genomic Variants
for PPIF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPIF (81107220 - 81115093 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PPIF
1 Indel: 58470 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIF |
|
Disorders
/ Diseases
for PPIF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPIF for disorders About GeneDecksing
OMIM gene information: 604486
OMIM disorders: --
6  diseases for PPIF: About MalaCardsfamilial dilated cardiomyopathy dilated cardiomyopathy cardiomyopathy toxoplasmosis
alzheimer's disease malaria
2 diseases from the University of Copenhagen DISEASES database for PPIF:Ullrich congenital muscular dystrophy Bethlem myopathy Human Genome Epidemiology (HuGE) Navigator: PPIF (4 documents)
Export disorders for PPIF gene to outside databases
|
Publications
for PPIF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPIF gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with PPIF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms. (PubMed id 1744118)1, 2, 3 Bergsma D.J.... Levy M.A. (1991)
- Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PubMed id 19228691)1, 2 Eliseev R.A....Gunter T.E. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- p53 opens the mitochondrial permeability transition po re to trigger necrosis. (PubMed id 22726440)2 Vaseva A.V....Moll U.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death. (PubMed id 20950273)2 McGee A.M. and Baines C.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for PPIF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPIF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPIF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPIF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for PPIF | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PPIF gene:
Search GeneIP for patents involving PPIF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PPIF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PPIF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIF | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPIF | | OriGene 3'-UTR Clone for PPIF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PPIF | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPIF | | OriGene Custom Protein Services for PPIF | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPIF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIF |
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| | | | Search Tocris compounds for PPIF |
| |  |  |  |  | | | | | | Recombinant Protein for PPIF |
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 | | | PPIF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIF |
|  |  |  | | | | ThermoFisher Antibodies for PPIF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIF |
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