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PPIF Gene

protein-coding   GIFtS: 67
GCID: GC10P081107

Peptidylprolyl Isomerase F

(Previous name: peptidylprolyl isomerase F (cyclophilin F))
  See PPIF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase F1 2     PPIase F2 3
Cyclophilin D1 2 3     EC 5.2.1.83 8
CYP32 3 5     Peptidylprolyl Isomerase F (Cyclophilin F)1
Cyclophilin F2 3     Cyp-D2
Mitochondrial Cyclophilin2 3     Cyclophilin 32
Rotamase F2 3     Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial2
CyP-M2 3     Peptidyl-Prolyl Cis-Trans Isomerase, Mitochondrial2
CypD2 3     CyP-D3

External Ids:    HGNC: 92591   Entrez Gene: 101052   Ensembl: ENSG000001081797   OMIM: 6044865   UniProtKB: P304053   

Export aliases for PPIF gene to outside databases

Previous GC identifers: GC10P080064 GC10P080316 GC10P080999 GC10P080451 GC10P080777 GC10P075101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPIF Gene:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding
of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial
membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell
death. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPIF Gene:
PPIF (peptidylprolyl isomerase F) is a protein-coding gene. Diseases associated with PPIF include bethlem myopathy, and ullrich congenital muscular dystrophy. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP).
It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate
(Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase
activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative
stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and
regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP
and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis

Gene Wiki entry for PPIF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIF gene promoter:
         RORalpha1   CREB   E2F-1   E2F   Sp1   Lmo2   CUTL1   Arnt   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIF promoter sequence
   Search Chromatin IP Primers for PPIF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22-q23   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q22-q23

PPIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIF gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P081107:  view genomic region     (about GC identifiers)

Start:
81,107,220 bp from pter      End:
81,115,093 bp from pter
Size:
7,874 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor  
Size: 207 amino acids; 22040 Da
Subunit: Believed to associate with the mitochondrial permeability transition pore complex (PTPC). Associates with
the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic
phosphate (Pi) and decreased by cyclosporin A (CsA). Interacts with ATP5B; ATP5H and ATP5O. Interacts with
SLC25A3; the interaction is impaired by CsA. Interacts with BCL2; the interaction is impaired by CsA. Interacts
with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is
impaired by CsA. Interacts with C1QBP
Selected PDB 3D structures from and Proteopedia for PPIF (see all 19):
2BIT (3D)        2BIU (3D)        2Z6W (3D)        3QYU (3D)        3R49 (3D)        3R4G (3D)    
Secondary accessions: Q5W131

Explore the universe of human proteins at neXtProt for PPIF: NX_P30405

Explore proteomics data for PPIF at MOPED

Post-translational modifications: 

  • Deacteylated at Lys-167 by SIRT3 (By similarity)1
  • Ubiquitination2 at Lys73
  • Glycosylation2 at Asn150
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIF (P30405) (see all 17)
     GVLSMAN  GGKSIYG  LSMANAG  DVVPKTA 


    See PPIF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005720.1  
    ENSEMBL proteins: 
     ENSP00000473548   ENSP00000225174   ENSP00000396388   ENSP00000378080  

    PPIF Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for PPIF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P30405

    ProtoNet protein and cluster: P30405

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIF_HUMAN, P30405
    Similarity: Belongs to the cyclophilin-type PPIase family
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Find genes that share domains with PPIF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIF_HUMAN, P30405
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP).
    It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate
    (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase
    activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative
    stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and
    regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP
    and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probablity
    of the mPTP

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding IPI--
    GO:0016018cyclosporin A binding IEA--
    GO:0042277peptide binding ----
         
    Find genes that share ontologies with PPIF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPIF:
     Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ppif):
     cardiovascular system  cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with PPIF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PPIF: Ppiftm1Tsu Ppiftm1.1Mmos Ppiftm1Maf Ppiftm1Jmol

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIF
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIF

    miRNA
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    miRTarBase miRNAs that target PPIF:
    hsa-mir-615-3p (MIRT040187), hsa-mir-320a (MIRT044495), hsa-mir-16-5p (MIRT001429), hsa-mir-124-3p (MIRT022323), hsa-mir-7-5p (MIRT025721), hsa-mir-21-5p (MIRT005331)

    Block miRNA regulation of human, mouse, rat PPIF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPIF (see all 18):
    hsa-miR-513a-5p hsa-miR-128 hsa-miR-520a-5p hsa-miR-3159 hsa-miR-124 hsa-miR-23a hsa-miR-3915 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPPIF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPIF

    Gene Editing
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIF

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIF_HUMAN, P30405: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----
    GO:0005753colocalizes with mitochondrial proton-transporting ATP synthase complex ISS--
    GO:0005759mitochondrial matrix IEA--
    GO:0016020membrane TAS1744118

    Find genes that share ontologies with PPIF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPIF About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    Huntington's disease0.45
    2Leishmaniasis
    Toxoplasmosis0.35
    3Calcium signaling pathway
    Calcium signaling pathway


    Find genes that share SuperPaths with PPIF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    4 Kegg Pathways  (Kegg details for PPIF):
        Calcium signaling pathway
    Parkinson's disease
    Huntington's disease
    Toxoplasmosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIF
    Interactions:

        Search GeneGlobe Interaction Network for PPIF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPIF (P304051, 3 ENSP000002251744) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    HIST1H4EP628053I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization ----
    GO:0002931response to ischemia ISS--
    GO:0006457protein folding IEA--
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0010849regulation of proton-transporting ATPase activity, rotational mechanism ISS--

    Find genes that share ontologies with PPIF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIF

    2 HMDB Compounds for PPIF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethyl sulfoxide(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)67-68-5--
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    3 DrugBank Compounds for PPIF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423
    1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane-- --target--10592235
    7-AMINO-4-METHYL-CHROMEN-2-ONE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPIF gene: 
    NM_005729.3  

    Unigene Cluster for PPIF:

    Peptidylprolyl isomerase F
    Hs.381072  [show with all ESTs]
    Unigene Representative Sequence: NM_005729
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498681 ENST00000472580 ENST00000225174(uc001kai.3 uc001kaj.3)
    ENST00000492149 ENST00000448165 ENST00000394579
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPIF (see all 18):
    hsa-miR-513a-5p hsa-miR-128 hsa-miR-520a-5p hsa-miR-3159 hsa-miR-124 hsa-miR-23a hsa-miR-3915 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPPIF 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PPIF
      QuantiFast Probe-based Assays in human, mouse, rat PPIF

    Additional mRNA sequence: 

    AK296669.1 AK312757.1 BC005020.1 BC013204.1 BC110299.1 M80254.1 

    19 DOTS entries:

    DT.447469  DT.100726706  DT.95168936  DT.100885193  DT.100885205  DT.100030764  DT.100885214  DT.121267742 
    DT.121267754  DT.100885190  DT.100885197  DT.101965040  DT.121267728  DT.95168938  DT.100885200  DT.100885201 
    DT.100885212  DT.40132562  DT.100885198 

    Selected AceView cDNA sequences (see all 594):

    H65953 CR613389 CB131161 AI300553 BM905141 CB305512 AI223065 AV706047 
    BM750610 CR618101 BM463013 BQ928762 BG171201 AI240981 CR600630 CR608381 
    AI744854 CR595750 CR610799 BM758800 Z38590 AL515519 CA390763 BM844113 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPIF (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
    SP1:                    -                 -     -                     
    SP2:                    -     -           -                           
    SP3:                    -     -           -     -                     
    SP4:                    -     -                                       
    SP5:                    -     -     -     -     -                     


    ECgene alternative splicing isoforms for PPIF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTGTGTT
    PPIF Expression
    About this image


    PPIF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Adrenal Gland (Endocrine System)
    PPIF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381072
        Custom PCR Arrays for PPIF
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    QuantiFast Probe-based Assays in human, mouse, rat PPIF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIF gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppif1 , 5 peptidylprolyl isomerase F (cyclophilin F)1, 5 87.86(n)1
    89.32(a)1
      14 (15.06 cM)5
    1056751  NM_134084.11  NP_598845.11 
     256941545 
    chicken
    (Gallus gallus)
    Aves PPIF1 peptidylprolyl isomerase F 72.64(n)
    83.08(a)
      423723  NM_001031226.1  NP_001026397.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPIF6
    peptidylprolyl isomerase F
    78(a)
    1 ↔ 1
    GL343468.1(590829-610574)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757152 hypothetical protein MGC75715 76.44(n)    BC059741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.268272 Transcribed sequence with moderate similarity to protein more 76.55(n)    CK361200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp11 , 3 protein folding cyclin-dependent
    protein kinase, more3
    Cyclophilin 11
    77(a)
    (best of 3)3
    72.67(n)1
    77.02(a)1
      14B123
    325951  NM_078642.31  NP_523366.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-33 Peptidyl-prolyl cis-trans isomerases 68(a)
    (best of 2)
      V(15192351-15193440)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR1(YDR155C)4
    CPR11
    Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), more4
    CPR11
    64.57(n)1
    70.44(a)1
      4(769000-768512)4
    8517331, 4  NP_010439.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP51 CYP5 61.64(n)
    68.55(a)
      817546  NM_128550.3  NP_180557.1 
    rice
    (Oryza sativa)
    Liliopsida AK061894.12   -- 78.5(n)    AK061894.1 


    ENSEMBL Gene Tree for PPIF (if available)
    TreeFam Gene Tree for PPIF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIF gene
    PPIE2  PPIAL4C2  RANBP22  RGPD62  PPIA2  PPIAL4D2  PPIAL4A2  RGPD22  
    RGPD42  PPIAL4G2  RGPD32  RGPD12  PPIAL4B2  RGPD52  RGPD82  
    Selected SIMAP similar genes for PPIF using alignment to 4 protein entries:     PPIF_HUMAN (see all proteins) (see all similar genes):
    RANBP2    PPIA    PPIE    PPIAL4A    PPIAL4B    PPIAL4C
    PPIAL4G    PPIAL4D    LOC402252    PPIC    PPID    PPIH
    PPIB    PPWD1    NKTR    PPIL6    PPIL1    DKFZp686G0426

    Find genes that share paralogs with PPIF           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for PPIF
    PGOHUM00000259631 PGOHUM00000250443 PGOHUM00000250271 PGOHUM00000250965 PGOHUM00000236691


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIF (see all 218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405793641,2
    --81105289(+) GCCTGA/GCTTCC 1 -- us2k10--------
    rs741423711,2
    C,F--81105528(+) TGGCCG/ACAGGG 1 -- us2k12Minor allele frequency- A:0.12WA 120
    rs733079461,2
    C,F--81105647(+) GCTCAG/AGTGGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs42469441,2
    C,F,A,H--81105684(+) GGGCAT/CAATCA 1 -- us2k130Minor allele frequency- C:0.45NA NS EA WA CSA 2508
    rs49800631,2
    C,F,A--81105844(+) TAGCCT/AAACTT 1 -- us2k110Minor allele frequency- A:0.48NA WA CSA EA 371
    rs1923176751,2
    --81105908(+) AATTTA/GCTTGG 1 -- us2k10--------
    rs1381930951,2
    --81105913(+) GCTTGA/GCTGGC 1 -- us2k10--------
    rs1428003271,2
    C--81105959(+) AGGATC/TTGGGG 1 -- us2k10--------
    rs13177961,2
    C,F--81105996(-) GGTGGG/ACAGGA 1 -- us2k13Minor allele frequency- A:0.00NA MN 208
    rs110029401,2
    C,F--81106017(+) GCTCAG/ACCCCA 1 -- us2k12Minor allele frequency- A:0.16CSA WA 120

    HapMap Linkage Disequilibrium report for PPIF (81107220 - 81115093 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPIF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819846CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIF
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604486    OMIM disorders: --

    2 diseases for PPIF:    
    About MalaCards
    bethlem myopathy    ullrich congenital muscular dystrophy

    2 diseases from the University of Copenhagen DISEASES database for PPIF:
    Ullrich congenital muscular dystrophy     Bethlem myopathy

    Find genes that share disorders with PPIF           About GenesLikeMe

    Genetic Association Database (GAD): PPIF
    Human Genome Epidemiology (HuGE) Navigator: PPIF (4 documents)

    Export disorders for PPIF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIF gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with PPIF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms. (PubMed id 1744118)1, 2, 3 Bergsma D.J.... Levy M.A. (J. Biol. Chem. 1991)
    2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    6. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PubMed id 19228691)1, 2 Eliseev R.A....Gunter T.E. (J. Biol. Chem. 2009)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10105 HGNC: 9259 AceView: PPIF Ensembl:ENSG00000108179 euGenes: HUgn10105
    ECgene: PPIF Kegg: 10105 H-InvDB: PPIF

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPIF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPIF gene:
    Search GeneIP for patents involving PPIF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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