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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIE Gene

protein-coding   GIFtS: 62
GCID: GC01P040157

peptidylprolyl isomerase E (cyclophilin E)

 Explore 5 diseases affiliated with
PPIE via our new
 Human Malady Compendium 
Biological research products
for PPIE
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase E (Cyclophilin E)1 2     MGC37361
Rotamase E2 3     CYP-332
CYP332 3     Cyclophilin-333
PPIase E2 3     Peptidyl-Prolyl Cis-Trans Isomerase E2
EC 5.2.1.83 8     Cyclophilin-333
CyP-331     Cyclophilin E3
MGC1112221     

External Ids:    HGNC: 92581   Entrez Gene: 104502   Ensembl: ENSG000000840727   OMIM: 6024355   UniProtKB: Q9UNP93   

Export aliases for PPIE gene to outside databases

Previous GC identifers: GC01P040234 GC01P039208 GC01P039668 GC01P039618 GC01P039619 GC01P039873 GC01P039977 GC01P038323


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIE:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of
proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was
shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative
splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has
been identified. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: PPIE_HUMAN, Q9UNP9
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and
brain-specific processes. May be involved in pre-mRNA splicing

Gene Wiki entry for PPIE


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIE gene promoter:
         HSF1 (long)   Nkx5-1   AREB6   HEN1   SRY   POU2F1   POU2F1a   HSF1short   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIE promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p32

PPIE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P040157:  view genomic region     (about GC identifiers)

Start:
40,157,854 bp from pter      End:
40,229,586 bp from pter
Size:
71,733 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPIE_HUMAN, Q9UNP9 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase E  
Size: 301 amino acids; 33431 Da
Subunit: Identified in the spliceosome C complex
Subcellular location: Nucleus
6/8 PDB 3D structures from and Proteopedia for PPIE (see all 8):
1ZMF (3D)        2CQB (3D)        2KU7 (3D)        2KYX (3D)        2R99 (3D)        3LPY (3D)    
Secondary accessions: B2R971 O43634 O43635 Q32Q72 Q5TGA0 Q5TGA2 Q9UIZ5
Alternative splicing: 2 isoforms:  Q9UNP9-1   Q9UNP9-2   

Explore the universe of human proteins at neXtProt for PPIE: NX_Q9UNP9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNP9

  • 4/12 DME Specific Peptides for PPIE (Q9UNP9) (see all 12)
     GGKSIYG  GLLSMAN  HVVFGEV  TNGSQFF 

    PPIE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001181936.1  NP_006103.1  NP_982281.1  

    ENSEMBL proteins: 
     ENSP00000436689   ENSP00000312769   ENSP00000348904   ENSP00000434989   ENSP00000433475  
     ENSP00000431714   ENSP00000361925   ENSP00000361918   ENSP00000432396   ENSP00000434888  

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    Uscn Proteins for PPIE

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11313484
    GO:0071013catalytic step 2 spliceosome IDA11991638


    PPIE for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PPIE for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016304 Cyclophilin-type_PPIase_E
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry Q9UNP9

    ProtoNet protein and cluster: Q9UNP9

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002130 Peptidyl-prolyl cis-trans isomerase


    UniProtKB/Swiss-Prot: PPIE_HUMAN, Q9UNP9
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PPIE_HUMAN, Q9UNP9
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and
    brain-specific processes. May be involved in pre-mRNA splicing
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for PPIE:
    cyclophilin E,FKB (FK506 binding protein)-type peptidyl-prolyl cis-trans-isomerase,highly expressed in muscle and
    brain,coamplified with MYCL1 in small cell lung cancer lines

    Enzyme Number (IUBMB): EC 5.2.1.81 2

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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS11313484
    GO:0003755peptidyl-prolyl cis-trans isomerase activity TAS11313484
    GO:0005515protein binding IPI--


    PPIE for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for PPIE):
        Spliceosome


    PPIE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for PPIE (Q9UNP91, 2, 3 ENSP000003127694) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3HP684313, ENSP000003581604I2D: score=1 STRING: ENSP00000358160
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0000413protein peptidyl-prolyl isomerization TAS11313484
    GO:0006355regulation of transcription, DNA-dependent IMP11313484
    GO:0006457protein folding IEA--
    GO:0045070positive regulation of viral genome replication IMP19932913


    PPIE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIE
    Search CenterWatch for drugs/clinical trials and news about PPIE 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIE gene (4 alternative transcripts): 
    NM_001195007.1  NM_006112.3  NM_203456.2  NM_203457.1  

    Unigene Cluster for PPIE:

    Peptidylprolyl isomerase E (cyclophilin E)
    Hs.524690  [show with all ESTs]
    Unigene Representative Sequence: NM_006112
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470018 ENST00000485507 ENST00000324379(uc001cds.2) ENST00000356511(uc001cdv.3)
    ENST00000456578 ENST00000495526(uc010oiy.2 uc001cdt.2 uc001cdu.2)
    ENST00000482751(uc001cdx.2) ENST00000497370 ENST00000470213 ENST00000372835
    ENST00000372830(uc001cdw.3) ENST00000474804 ENST00000475350 ENST00000480169
    ENST00000467741

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    SwitchGear 3'UTR luciferase reporter plasmidPPIE 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF042385.1 AF042386.1 AF104012.1 AF104013.1 AK130628.1 AK293094.1 AK304694.1 AK313666.1 
    BC004898.2 BC008451.1 BC107736.1 DQ160195.1 NR_036543.1 NR_036544.1 

    24/26 DOTS entries (see all 26):

    DT.91850857  DT.100818139  DT.121332077  DT.100818126  DT.100818129  DT.100818131  DT.452644  DT.110343 
    DT.100038341  DT.100818137  DT.121332020  DT.100818123  DT.91669360  DT.100818124  DT.100818130  DT.100818136 
    DT.316702  DT.92453650  DT.92453664  DT.97862118  DT.100818127  DT.121332022  DT.121332043  DT.92453660 

    24/433 AceView cDNA sequences (see all 433):

    BM824407 BU528681 BU521600 T29866 BQ920838 BU849507 BG654820 BE266145 
    BQ919201 BQ691700 BU786217 BU854991 CF530091 BM748952 BU177231 BU160972 
    BU849502 BU196539 CA445146 BU790399 BM782779 AA916320 BC004898 CR625617 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PPIE (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a ·
    SP1:                                -     -                 -           -     -     -                                         -     -     -                     
    SP2:                                -     -                 -           -     -     -                 -                       -     -     -                     
    SP3:                          -     -     -                 -           -     -     -                                         -     -     -                     
    SP4:                                -     -                 -           -     -     -                 -     -     -     -     -     -     -                     
    SP5:                                -                       -           -     -     -                                                                           

    ExUns: 11b ^ 12a · 12b
    SP1:  -               
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for PPIE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAGGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PPIE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIE

    SOURCE GeneReport for Unigene cluster: Hs.524690

    UniProtKB/Swiss-Prot: PPIE_HUMAN, Q9UNP9
    Tissue specificity: Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle,
    kidney and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIE gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPIE1 peptidylprolyl isomerase E (cyclophilin E) 81.73(n)
    91.69(a)
      426061  XM_423739.3  XP_423739.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPIE6
    --
    87(a)
    1 ↔ 1
    GL343481.1(246706-253545)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.27322 Xenopus laevis transcribed sequence with moderate similarity more 80.99(n)    BJ062790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059470.12   -- 79.02(n)   335519  BC059470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp13
    cyp331
    protein folding cyclin-dependent protein
    kinase, more3
    cyclophilin-331
    71(a)
    (best of 3)3
    64.64(n)1
    66.89(a)1
      14B123
    369841  NM_079049.31  NP_523773.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-33
    cyn-131
    Peptidyl-prolyl cis-trans isomerases3
    Protein CYN-131
    65(a)
    (best of 4)3
    59.17(n)1
    64.01(a)1
      V(15192351-15193440)3
    1784871  NM_070633.41  NP_503034.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP51 Peptidyl-prolyl cis-trans isomerase CYP19-4 63.73(n)
    66.04(a)
      817546  NM_128550.3  NP_180557.1 
    rice
    (Oryza sativa)
    Liliopsida Os.54922 Oryza sativa cyclophilin 1 (Cyp1) mRNA, complete cds 77.41(n)    AK103109.1 


    ENSEMBL Gene Tree for PPIE (if available)
    TreeFam Gene Tree for PPIE (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIE gene
    PPIAL4A2  PPIAL4C2  PPIAL4G2  PPIF2  PPIAL4B2  PPIA2  PPIAL4D2  
    18/25 SIMAP similar genes for PPIE using alignment to 9 protein entries:     PPIE_HUMAN (see all proteins) (see all similar genes):
    PPIF    PPIA    LOC402252    PPIAL4A    PPIAL4B    PPIAL4C
    PPIAL4G    PPIH    PPIC    RANBP2    PPIB    FUSIP1
    PPID    NKTR    PPIL1    PPIG    PPIL6    DKFZp686G0426

    PPIE for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPIE
    PGOHUM00000243975


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/356 NCBI SNPs in PPIE are shown (see all 356    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs578067401,2
    C--40202562(+) AAAAA-/ATTAGC 5 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1428768871,2
    --40202600(+) CATGGC/TGACGT 5 -- us2k10--------
    rs1176308361,2
    F,--40202604(+) GTGACG/ATGCAC 5 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1168057941,2
    F,--40202612(+) CACCTG/ATACTC 5 -- us2k11Minor allele frequency- A:0.02WA 118
    rs729407341,2
    C,--40202649(+) GGGAGG/AATCAT 5 -- us2k11Minor allele frequency- A:0.50WA 2
    rs66582731,2
    C,F,A,--40202722(+) AAGAGA/TGCAAG 5 -- us2k19Minor allele frequency- T:0.23NA WA EA 370
    rs1400295381,2
    --40202895(+) GATGTA/GAGCAT 5 -- us2k10--------
    rs770904711,2
    --40202900(+) GAGCAG/TGTAAC 5 -- us2k10--------
    rs1505889631,2
    --40202945(+) CCCAAA/GTCTTC 5 -- us2k10--------
    rs1396607291,2
    --40203102(+) CAGAAC/TTCAGC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIE (40157854 - 40229586 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PPIE
         2 CNVs: 53124 3289

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PPIE for disorders           About GeneDecksing

    OMIM gene information: 602435    OMIM disorders: --

    5 diseases for PPIE:    About MalaCards
    interstitial emphysema    emphysema    lung cancer    obesity
    malaria

    Human Genome Epidemiology (HuGE) Navigator: PPIE (1 document)

    Export disorders for PPIE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIE gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PPIE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. (PubMed id 9747881)1, 2, 3, 9 Kim J.-O.... Kelley M.J. (1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. A nuclear RNA-binding cyclophilin in human T cells. (PubMed id 8977107)1, 2 Mi H.... Tropschug M. (1996)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10450 HGNC: 9258 AceView: PPIE Ensembl:ENSG00000084072 euGenes: HUgn10450
    ECgene: PPIE Kegg: 10450 H-InvDB: PPIE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPIE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIE gene:
    Search GeneIP for patents involving PPIE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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