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Aliases for PPIE Gene

Aliases for PPIE Gene

  • Peptidylprolyl Isomerase E 2 3 5
  • Rotamase E 2 3 4
  • PPIase E 2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase E 2 3
  • Cyclophilin-33 3 4
  • Cyclophilin E 2 4
  • EC 5.2.1.8 4 61
  • CYP33 3 4
  • Peptidylprolyl Isomerase E (Cyclophilin E) 3
  • Peptidylprolyl Isomerase E, Isoform 1 2
  • Cyclophilin 33 2
  • CYP-33 3

External Ids for PPIE Gene

Previous GeneCards Identifiers for PPIE Gene

  • GC01P040234
  • GC01P039208
  • GC01P039668
  • GC01P039618
  • GC01P039619
  • GC01P039873
  • GC01P039977
  • GC01P040157
  • GC01P038323

Summaries for PPIE Gene

Entrez Gene Summary for PPIE Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

GeneCards Summary for PPIE Gene

PPIE (Peptidylprolyl Isomerase E) is a Protein Coding gene. Among its related pathways are Immune System and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RANBP2.

UniProtKB/Swiss-Prot for PPIE Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIE Gene

Genomics for PPIE Gene

Regulatory Elements for PPIE Gene

Enhancers for PPIE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F039738 0.2 ENCODE 84.9 +46.8 46831 1.8 ATF1 SIN3A ZNF2 YY1 GLIS2 ELK1 SP3 YY2 ZHX2 ZNF518A PPIE BMP8B OXCT2 ENSG00000202222 TRIT1 PIR58872 RNU7-121P
GH01F039775 0.8 Ensembl 16 +84.0 84010 1.2 PKNOX1 ARNT NFRKB BMI1 ZBTB40 POLR2A EED ETV6 FOS CREM PPIE OXCT2 OXCT2P1 BMP8B LOC105378666
GH01F039645 0.7 Ensembl ENCODE 11.4 -45.3 -45275 3.4 BCOR CTCF ZNF146 TEAD4 MAX ZMYM3 ZFHX2 POLR2A SCRT2 ADNP HPCAL4 NT5C1A PPIE PABPC4 HEYL OXCT2
GH01F039657 1.1 Ensembl ENCODE 11.3 -34.1 -34066 0.6 CTCF CBX3 TBL1XR1 RAD21 ZNF324 POLR2A ZNF143 SMC3 CREM ZHX1 ENSG00000225903 HPCAL4 PPIE NT5C1A HEYL
GH01F039652 0.7 Ensembl ENCODE 11.2 -39.1 -39127 1.9 CTCF ESRRA ZNF384 ZNF2 RAD21 ZEB1 ZNF664 ZFHX2 GATA3 GATA2 HPCAL4 PPIE PABPC4 OXCT2 HEYL NT5C1A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPIE on UCSC Golden Path with GeneCards custom track

Promoters for PPIE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001743999 -682 601 PKNOX1 SUZ12 INSM2 KLF17 UBTF BMI1 ZNF2 NFYB FOS ZNF600

Genomic Location for PPIE Gene

Chromosome:
1
Start:
39,692,182 bp from pter
End:
39,763,914 bp from pter
Size:
71,733 bases
Orientation:
Plus strand

Genomic View for PPIE Gene

Genes around PPIE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIE Gene

Proteins for PPIE Gene

  • Protein details for PPIE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNP9-PPIE_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase E
    Protein Accession:
    Q9UNP9
    Secondary Accessions:
    • B2R971
    • O43634
    • O43635
    • Q32Q72
    • Q3S611
    • Q5TGA0
    • Q5TGA2
    • Q5TGA3
    • Q9UIZ5

    Protein attributes for PPIE Gene

    Size:
    301 amino acids
    Molecular mass:
    33431 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.

    Three dimensional structures from OCA and Proteopedia for PPIE Gene

    Alternative splice isoforms for PPIE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIE Gene

Post-translational modifications for PPIE Gene

  • Ubiquitination at Lys 218
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PPIE Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNP9

UniProtKB/Swiss-Prot:

PPIE_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
genes like me logo Genes that share domains with PPIE: view

Function for PPIE Gene

Molecular function for PPIE Gene

GENATLAS Biochemistry:
cyclophilin E,FKB (FK506 binding protein)-type peptidyl-prolyl cis-trans-isomerase,highly expressed in muscle and brain,coamplified with MYCL1 in small cell lung cancer lines
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIE Gene

Gene Ontology (GO) - Molecular Function for PPIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS 11313484
GO:0003755 peptidyl-prolyl cis-trans isomerase activity TAS 11313484
GO:0005515 protein binding IPI 11313484
genes like me logo Genes that share ontologies with PPIE: view
genes like me logo Genes that share phenotypes with PPIE: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIE

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIE Gene

Localization for PPIE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIE Gene COMPARTMENTS Subcellular localization image for PPIE gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PPIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11313484
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIE: view

Pathways & Interactions for PPIE Gene

genes like me logo Genes that share pathways with PPIE: view

Pathways by source for PPIE Gene

Gene Ontology (GO) - Biological Process for PPIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006355 regulation of transcription, DNA-templated IMP 11313484
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with PPIE: view

No data available for SIGNOR curated interactions for PPIE Gene

Transcripts for PPIE Gene

Unigene Clusters for PPIE Gene

Peptidylprolyl isomerase E (cyclophilin E):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIE Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: - - -
SP13:
SP14: - - -
SP15: - - -

ExUns: 11b ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PPIE Gene

GeneLoc Exon Structure for
PPIE
ECgene alternative splicing isoforms for
PPIE

Expression for PPIE Gene

mRNA expression in normal human tissues for PPIE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIE Gene

This gene is overexpressed in Liver (19.9), Heart (10.1), Peripheral blood mononuclear cells (8.7), and Spleen (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIE Gene



Protein tissue co-expression partners for PPIE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIE Gene:

PPIE

SOURCE GeneReport for Unigene cluster for PPIE Gene:

Hs.524690

mRNA Expression by UniProt/SwissProt for PPIE Gene:

Q9UNP9-PPIE_HUMAN
Tissue specificity: Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with PPIE: view

Primer Products

No data available for mRNA differential expression in normal tissues for PPIE Gene

Orthologs for PPIE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIE 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia PPIE 34 35
  • 92.47 (n)
cow
(Bos Taurus)
Mammalia PPIE 34 35
  • 91.81 (n)
mouse
(Mus musculus)
Mammalia Ppie 34 16 35
  • 90.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPIE 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIE 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIE 34 35
  • 81.73 (n)
lizard
(Anolis carolinensis)
Reptilia PPIE 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppie 34
  • 77.74 (n)
Str.10680 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2732 34
zebrafish
(Danio rerio)
Actinopterygii ppie 34 35
  • 76.3 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Cyp1 36
  • 71 (a)
CG7768 36
  • 69 (a)
cyp33 36 34 35
  • 64.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009810 34
  • 65.11 (n)
worm
(Caenorhabditis elegans)
Secernentea cyp-3 36
  • 65 (a)
cyp-7 36
  • 64 (a)
cyp-13 36
  • 60 (a)
cyn-2 35
  • 60 (a)
ManyToMany
cyn-7 35
  • 60 (a)
ManyToMany
cyn-3 35
  • 59 (a)
ManyToMany
cyn-13 34
  • 58.95 (n)
cyn-1 35
  • 56 (a)
ManyToMany
cyp-8 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR1 35
  • 57 (a)
ManyToMany
CPR3 35
  • 51 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55920 34
  • 62.05 (n)
rice
(Oryza sativa)
Liliopsida Os.5492 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2828 35
  • 61 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5879 34
Species where no ortholog for PPIE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIE Gene

ENSEMBL:
Gene Tree for PPIE (if available)
TreeFam:
Gene Tree for PPIE (if available)

Paralogs for PPIE Gene

Variants for PPIE Gene

Sequence variations from dbSNP and Humsavar for PPIE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1046988 -- 39,753,393(+) TGACC(C/T)TGCAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1053846 -- 39,757,468(-) AAGTA(A/C)CATGT intron-variant, utr-variant-3-prime
rs1073885 -- 39,754,821(-) gagta(A/C)agtgg intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10888958 -- 39,746,065(+) GGTTT(C/T)TATTT intron-variant
rs10888962 -- 39,754,773(+) ggatc(A/G)cttga intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPIE Gene

Variant ID Type Subtype PubMed ID
dgv152n100 CNV gain 25217958
dgv153n100 CNV gain 25217958
dgv15n27 CNV gain 19166990
esv2758933 CNV loss 17122850
nsv1116447 OTHER inversion 24896259
nsv546062 CNV gain 21841781
nsv546063 CNV gain 21841781
nsv7177 OTHER inversion 18451855
nsv945894 CNV duplication 23825009
nsv950654 CNV deletion 24416366

Variation tolerance for PPIE Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIE Gene

Disorders for PPIE Gene

Relevant External Links for PPIE

Genetic Association Database (GAD)
PPIE
Human Genome Epidemiology (HuGE) Navigator
PPIE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIE

No disorders were found for PPIE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIE Gene

Publications for PPIE Gene

  1. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. (PMID: 9747881) Kim J.-O. … Kelley M.J. (Oncogene 1998) 2 3 4 22 64
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PPIE Gene

Sources for PPIE Gene

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