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Aliases for PPIE Gene

Aliases for PPIE Gene

  • Peptidylprolyl Isomerase E (Cyclophilin E) 2 3
  • Rotamase E 2 3 4
  • PPIase E 2 3 4
  • CYP33 3 4 6
  • Peptidyl-Prolyl Cis-Trans Isomerase E 2 3
  • Cyclophilin-33 3 4
  • Cyclophilin E 2 4
  • EC 5.2.1.8 4 63
  • Peptidylprolyl Isomerase E 2
  • Cyclophilin 33 2
  • Isoform 1 2
  • CYP-33 3

External Ids for PPIE Gene

Previous GeneCards Identifiers for PPIE Gene

  • GC01P040234
  • GC01P039208
  • GC01P039668
  • GC01P039618
  • GC01P039619
  • GC01P039873
  • GC01P039977
  • GC01P040157
  • GC01P038323

Summaries for PPIE Gene

Entrez Gene Summary for PPIE Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

GeneCards Summary for PPIE Gene

PPIE (Peptidylprolyl Isomerase E (Cyclophilin E)) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include RNA binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is RGPD8.

UniProtKB/Swiss-Prot for PPIE Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing

Gene Wiki entry for PPIE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIE Gene

Genomics for PPIE Gene

Regulatory Elements for PPIE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIE Gene

Start:
39,692,182 bp from pter
End:
39,763,914 bp from pter
Size:
71,733 bases
Orientation:
Plus strand

Genomic View for PPIE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIE Gene

Proteins for PPIE Gene

  • Protein details for PPIE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNP9-PPIE_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase E
    Protein Accession:
    Q9UNP9
    Secondary Accessions:
    • B2R971
    • O43634
    • O43635
    • Q32Q72
    • Q3S611
    • Q5TGA0
    • Q5TGA2
    • Q5TGA3
    • Q9UIZ5

    Protein attributes for PPIE Gene

    Size:
    301 amino acids
    Molecular mass:
    33431 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.

    Three dimensional structures from OCA and Proteopedia for PPIE Gene

    Alternative splice isoforms for PPIE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIE Gene

Proteomics data for PPIE Gene at MOPED

Post-translational modifications for PPIE Gene

  • Ubiquitination at Lys218
  • Modification sites at PhosphoSitePlus

Domains for PPIE Gene

Gene Families for PPIE Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

Q9UNP9

UniProtKB/Swiss-Prot:

PPIE_HUMAN :
  • Q9UNP9
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
genes like me logo Genes that share domains with PPIE: view

Function for PPIE Gene

Molecular function for PPIE Gene

GENATLAS Biochemistry: cyclophilin E,FKB (FK506 binding protein)-type peptidyl-prolyl cis-trans-isomerase,highly expressed in muscle and brain,coamplified with MYCL1 in small cell lung cancer lines
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for PPIE Gene

Gene Ontology (GO) - Molecular Function for PPIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 11313484
GO:0003755 peptidyl-prolyl cis-trans isomerase activity TAS 11313484
GO:0005515 protein binding IPI 11313484
genes like me logo Genes that share ontologies with PPIE: view

Animal Model Products

miRNA for PPIE Gene

miRTarBase miRNAs that target PPIE

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIE Gene

Localization for PPIE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIE Gene COMPARTMENTS Subcellular localization image for PPIE gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PPIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11313484
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIE: view

Pathways for PPIE Gene

SuperPathways for PPIE Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with PPIE: view

Pathways by source for PPIE Gene

1 KEGG pathway for PPIE Gene

Gene Ontology (GO) - Biological Process for PPIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006355 regulation of transcription, DNA-templated IMP 11313484
GO:0006457 protein folding IEA --
GO:0045070 positive regulation of viral genome replication IMP 19932913
genes like me logo Genes that share ontologies with PPIE: view

Transcripts for PPIE Gene

Unigene Clusters for PPIE Gene

Peptidylprolyl isomerase E (cyclophilin E):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIE

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIE Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: - - -
SP13:
SP14: - - -
SP15: - - -

ExUns: 11b ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PPIE Gene

GeneLoc Exon Structure for
PPIE
ECgene alternative splicing isoforms for
PPIE

Expression for PPIE Gene

mRNA expression in normal human tissues for PPIE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIE Gene

SOURCE GeneReport for Unigene cluster for PPIE Gene Hs.524690

mRNA Expression by UniProt/SwissProt for PPIE Gene

Q9UNP9-PPIE_HUMAN
Tissue specificity: Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with PPIE: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPIE Gene

Orthologs for PPIE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIE 35
  • 99.78 (n)
  • 100 (a)
PPIE 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPIE 35
  • 91.81 (n)
  • 98.01 (a)
PPIE 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIE 35
  • 92.47 (n)
  • 99.34 (a)
PPIE 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppie 35
  • 90.92 (n)
  • 98.34 (a)
Ppie 16
Ppie 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIE 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIE 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIE 35
  • 81.73 (n)
  • 91.69 (a)
PPIE 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIE 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2732 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppie 35
  • 77.74 (n)
  • 88.7 (a)
Str.10680 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ppie 35
  • 76.3 (n)
  • 86.71 (a)
ppie 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009810 35
  • 65.11 (n)
  • 67.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta cyp33 35
  • 64.64 (n)
  • 66.89 (a)
cyp33 36
  • 64 (a)
OneToOne
cyp33 37
  • 65 (a)
CG7768 37
  • 69 (a)
Cyp1 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-1 36
  • 56 (a)
ManyToMany
cyn-13 35
  • 58.95 (n)
  • 63.86 (a)
cyn-2 36
  • 60 (a)
ManyToMany
cyn-3 36
  • 59 (a)
ManyToMany
cyn-7 36
  • 60 (a)
ManyToMany
cyp-8 37
  • 52 (a)
cyp-13 37
  • 60 (a)
cyp-3 37
  • 65 (a)
cyp-7 37
  • 64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR1 36
  • 57 (a)
ManyToMany
CPR3 36
  • 51 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55920 35
  • 62.05 (n)
  • 67.3 (a)
rice
(Oryza sativa)
Liliopsida Os.5492 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5879 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2828 36
  • 61 (a)
OneToOne
Species with no ortholog for PPIE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIE Gene

ENSEMBL:
Gene Tree for PPIE (if available)
TreeFam:
Gene Tree for PPIE (if available)

Paralogs for PPIE Gene

Pseudogenes.org Pseudogenes for PPIE Gene

genes like me logo Genes that share paralogs with PPIE: view

Variants for PPIE Gene

Sequence variations from dbSNP and Humsavar for PPIE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14528 -- 39,753,608(+) GCCAC(C/T)GGCTT intron-variant, utr-variant-3-prime, nc-transcript-variant
rs476494 -- 39,747,285(-) acagg(A/G)attta intron-variant
rs491164 -- 39,743,736(+) CACAT(A/G)GCATC intron-variant
rs491863 -- 39,747,487(+) agaca(A/G)agtct intron-variant
rs492721 -- 39,747,581(+) cctca(A/G)cctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIE Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855
dgv15n27 CNV Gain 19166990
dgv215n71 CNV Loss 21882294
dgv49e1 CNV Complex 17122850

Relevant External Links for PPIE Gene

HapMap Linkage Disequilibrium report
PPIE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIE Gene

Disorders for PPIE Gene

Relevant External Links for PPIE

Genetic Association Database (GAD)
PPIE
Human Genome Epidemiology (HuGE) Navigator
PPIE
genes like me logo Genes that share disorders with PPIE: view

No data available for UniProtKB/Swiss-Prot for PPIE Gene

Publications for PPIE Gene

  1. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. (PMID: 9747881) Kim J.-O. … Kelley M.J. (Oncogene 1998) 2 3 4 23
  2. A nuclear RNA-binding cyclophilin in human T cells. (PMID: 8977107) Mi H. … Tropschug M. (FEBS Lett. 1996) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for PPIE Gene

  • Addgene plasmids for PPIE

Sources for PPIE Gene

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