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Aliases for PPID Gene

Aliases for PPID Gene

  • Peptidylprolyl Isomerase D 2 3
  • Cyclophilin-Related Protein 3 4
  • Cyclophilin 40 2 3
  • Cyclophilin-40 3 4
  • Rotamase D 3 4
  • EC 5.2.1.8 4 64
  • PPIase D 3 4
  • CYP-40 3 4
  • CypD 3 4
  • 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase D 3
  • Peptidylprolyl Isomerase D (Cyclophilin D) 2
  • 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase 4
  • Peptidyl-Prolyl Cis-Trans Isomerase D 3
  • Cyclophilin D 3
  • CYP40 4

External Ids for PPID Gene

Summaries for PPID Gene

Entrez Gene Summary for PPID Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPID Gene

PPID (Peptidylprolyl Isomerase D) is a Protein Coding gene. Diseases associated with PPID include mitochondrial disorders. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transcription factor binding and estrogen receptor binding. An important paralog of this gene is NKTR.

UniProtKB/Swiss-Prot for PPID Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Gene Wiki entry for PPID Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPID Gene

Genomics for PPID Gene

Genomic Location for PPID Gene

Start:
158,709,127 bp from pter
End:
158,723,400 bp from pter
Size:
14,274 bases
Orientation:
Minus strand

Genomic View for PPID Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPID Gene

Proteins for PPID Gene

  • Protein details for PPID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08752-PPID_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase D
    Protein Accession:
    Q08752
    Secondary Accessions:
    • B2R9V2

    Protein attributes for PPID Gene

    Size:
    370 amino acids
    Molecular mass:
    40764 Da
    Quaternary structure:
    • Identified in ESR1 or NR3C1/GCR steroid receptor-chaperone complexes. Found in HSP90 chaperone complexes with kinase clients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1. Interacts with HSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive with the PPID:HSPA8 interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8 and the interaction is mutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1 and S100A2; the interactions dissociate the PPID:HSP90AA1 interaction. Interacts with S100A6. Interacts with MYB, ILF2, XRCC6, GNB2L1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain (DYNC1I1 or DYNC1I2).

neXtProt entry for PPID Gene

Proteomics data for PPID Gene at MOPED

Post-translational modifications for PPID Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys218, Lys283, and Lys341

Other Protein References for PPID Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PPID Gene

Gene Families for PPID Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

UniProtKB/Swiss-Prot:

PPID_HUMAN
Domain:
  • Contains 1 PPIase cyclophilin-type domain.:
    • Q08752
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.:
    • Q08752
Similarity:
  • Contains 3 TPR repeats.:
    • Q08752
genes like me logo Genes that share domains with PPID: view

Function for PPID Gene

Molecular function for PPID Gene

GENATLAS Biochemistry: cyclophilin 40kDa,with intrinsic peptidyl-prolyl cis-trans isomerase activity,component of an unactivated steroid hormone receptor complex (see FKBP2)
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation: Less sensitive to inhibition by cyclosporin A than is CYP-18
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Enzyme Numbers (IUBMB) for PPID Gene

Gene Ontology (GO) - Molecular Function for PPID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 11350175
GO:0005515 protein binding IPI 16507998
GO:0008134 transcription factor binding IDA 9659917
GO:0016018 cyclosporin A binding TAS 7744028
GO:0030331 estrogen receptor binding ISS --
genes like me logo Genes that share ontologies with PPID: view

miRNA for PPID Gene

miRTarBase miRNAs that target PPID

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPID Gene

Localization for PPID Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPID Gene

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPID Gene COMPARTMENTS Subcellular localization image for PPID gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PPID: view

Pathways for PPID Gene

genes like me logo Genes that share pathways with PPID: view

Pathways by source for PPID Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PPID Gene
2 Qiagen pathways for PPID Gene
1 BioSystems pathway for PPID Gene

Gene Ontology (GO) - Biological Process for PPID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18708059
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding ISS --
GO:0006461 protein complex assembly IDA 18708059
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PPID: view

Compounds for PPID Gene

(3) Novoseek inferred chemical compound relationships for PPID Gene

Compound -log(P) Hits PubMed IDs
cyclosporin a 59.3 8
tacrolimus 58.3 3
steroid 38.2 1
genes like me logo Genes that share compounds with PPID: view

Transcripts for PPID Gene

mRNA/cDNA for PPID Gene

Unigene Clusters for PPID Gene

Peptidylprolyl isomerase D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPID Gene

No ASD Table

Relevant External Links for PPID Gene

GeneLoc Exon Structure for
PPID
ECgene alternative splicing isoforms for
PPID

Expression for PPID Gene

mRNA expression in normal human tissues for PPID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPID Gene

SOURCE GeneReport for Unigene cluster for PPID Gene Hs.183958

mRNA Expression by UniProt/SwissProt for PPID Gene

Q08752-PPID_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with PPID: view

Orthologs for PPID Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPID 36
  • 99.64 (n)
  • 99.19 (a)
PPID 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPID 36
  • 90 (n)
  • 93.78 (a)
PPID 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPID 36
  • 92.97 (n)
  • 93.24 (a)
PPID 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppid 36
  • 90.45 (n)
  • 94.32 (a)
Ppid 16
Ppid 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPID 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppid 36
  • 90.72 (n)
  • 93.51 (a)
chicken
(Gallus gallus)
Aves PPID 36
  • 76.58 (n)
  • 81.62 (a)
PPID 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPID 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4643 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75854 36
ppid 36
  • 73.42 (n)
  • 77.03 (a)
zebrafish
(Danio rerio)
Actinopterygii ppid 36
  • 67.66 (n)
  • 72.16 (a)
ppid 37
  • 80 (a)
OneToOne
wufb18b07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003265 36
  • 47.79 (n)
  • 43.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8336 36
  • 47.23 (n)
  • 41.69 (a)
CG8336 37
  • 36 (a)
OneToOne
CG8336 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-8 38
  • 51 (a)
cyp-3 38
  • 66 (a)
cyp-7 38
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR087C 36
  • 46.8 (n)
  • 42.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 36
  • 53.41 (n)
  • 48.3 (a)
CPR6 37
  • 45 (a)
OneToMany
CPR6 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05093g 36
  • 52.94 (n)
  • 46.5 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SQN 36
  • 53.98 (n)
  • 50 (a)
rice
(Oryza sativa)
Liliopsida Os06g0216800 36
  • 53.06 (n)
  • 49.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03853 36
  • 53.62 (n)
  • 54.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes wis2 36
  • 53.69 (n)
  • 47.79 (a)
Species with no ortholog for PPID:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPID Gene

ENSEMBL:
Gene Tree for PPID (if available)
TreeFam:
Gene Tree for PPID (if available)

Paralogs for PPID Gene

Paralogs for PPID Gene

genes like me logo Genes that share paralogs with PPID: view

Variants for PPID Gene

Sequence variations from dbSNP and Humsavar for PPID Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8396 -- 158,709,665(-) TGTCT(A/G)TGAAT utr-variant-3-prime
rs9410 - 158,710,839(-) TTGAA(A/C)TAGAC missense, reference
rs2070629 -- 158,723,349(-) GTTTG(A/G)GCGGC utr-variant-5-prime
rs2070630 -- 158,723,342(-) CGGCC(C/G)GGGCG utr-variant-5-prime
rs2070631 - 158,721,424(-) ATTTT(C/T)GTGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PPID Gene

Variant ID Type Subtype PubMed ID
nsv830125 CNV Gain 17160897

Relevant External Links for PPID Gene

HapMap Linkage Disequilibrium report
PPID

Disorders for PPID Gene

(1) MalaCards Diseases for PPID Gene

Search for PPID Gene in MalaCards »

(2) Novoseek inferred disease relationships for PPID Gene

Disease -log(P) Hits PubMed IDs
colon cancer 24.6 1
tumors 0 2

Relevant External Links for PPID

Genetic Association Database (GAD)
PPID
genes like me logo Genes that share disorders with PPID: view

No data available for UniProtKB/Swiss-Prot for PPID Gene

Publications for PPID Gene

  1. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. (PMID: 11350175) Pirkl F. … Buchner J. (J. Mol. Biol. 2001) 3 4 23
  2. Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. (PMID: 8509368) Kieffer L.J. … Bayney R.M. (J. Biol. Chem. 1993) 2 3 4
  3. The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. (PMID: 8812478) Yokoi H. … Ikeda J.E. (Genomics 1996) 3 4
  4. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PMID: 9195923) Silverstein A.M. … Pratt W.B. (J. Biol. Chem. 1997) 3 23
  5. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. (PMID: 20023700) Periyasamy S. … Sanchez E.R. (Oncogene 2010) 3 23

Products for PPID Gene

Sources for PPID Gene

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