PPID Gene
protein-coding GIFtS: 61
GCID: GC04M159630
|
|
peptidylprolyl isomerase D(Previous name: peptidylprolyl isomerase D (cyclophilin D) )
| |
Aliases
for PPID gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peptidylprolyl Isomerase D1 2 | | 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase D2 | | CYP-401 2 3 | | Cyclophilin 402 | | Cyclophilin-Related Protein2 3 | | Cyclophilin D2 | | Rotamase D2 3 | | Cyclophilin-403 | | CYPD2 3 | | Peptidyl-Prolyl Cis-Trans Isomerase D2 | | PPIase D2 3 | | 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase3 | | EC 5.2.1.83 8 | | CYP403 | | Peptidylprolyl Isomerase D (Cyclophilin D)1 | | Cyclophilin-403 |
Export aliases for PPID gene to outside databasesPrevious GC identifers: GC04M160480 GC04M160059 GC04M160207 GC04M159987 GC04M159849 GC04M155380 |
Summaries
for PPID gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPID:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIasescatalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding ofproteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to theimmunosuppressant cyclosporin A. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroidreceptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishingdistinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May beinvolved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYBby inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of theAHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UVradiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-celllymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release
Gene Wiki entry for PPID
|
Genomic Views
for PPID gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPID gene promoter:
STAT1 AML1a STAT1beta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 STAT1alpha FOXL1 PPAR-alpha STAT2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPID
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPID |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q31.3 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q31.3PPID Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M159630: view genomic region
(about GC identifiers)
Start:
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159,630,279 bp from pter |
End:
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159,644,552 bp from pter |
Size:
|
14,274 bases |
Orientation:
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minus strand |
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Proteins
for PPID gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase D Size: 370 amino acids; 40764 Da
Subunit: Identified in an ESR1 steroid receptor-chaperone complex. Found in HSP90 chaperone complexes with kinaseclients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1. Interacts withHSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive with the PPID:HSPA8interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8 and the interaction ismutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1; the interaction dissociates thePPID:HSP90AA1 interaction. Interacts with S100A2; the interaction dissociates the PPID:HSP90AA1 interaction. Interactswith S100A6. Interacts with MYB, ILF2, XRCC6, GNB2L1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain(DYNC1I1 or DYNC1I2)
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm
Caution: This protein should not be confused with mitochondrial peptidyl-prolyl cis-trans isomerase F (PPIF) which isoften referred to as cyclophilin D or CypD
Secondary accessions: B2R9V2Explore the universe of human proteins at neXtProt for PPID: NX_Q08752
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08752
4/14 DME Specific Peptides for PPID (Q08752) (see all 14)
PPID Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005029.1
ENSEMBL proteins: ENSP00000303754 ENSP00000423207 ENSP00000421221
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
PPID for ontologies About GeneDecksing
PPID Antibody Products:
Assay Products for PPID: |
Protein
Domains /
Families
for PPID gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPID for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08752ProtoNet protein and cluster: Q08752 1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase
UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752Similarity: Belongs to the cyclophilin-type PPIase family. PPIase D subfamilySimilarity: Contains 1 PPIase cyclophilin-type domainSimilarity: Contains 3 TPR repeats |
Function
for PPID gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroidreceptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishingdistinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May beinvolved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYBby inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of theAHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UVradiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-celllymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and releaseCatalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme regulation: Less sensitive to inhibition by cyclosporin A than is CYP-18 Genatlas biochemistry entry for PPID:cyclophilin 40kDa,with intrinsic peptidyl-prolyl cis-trans isomerase activity,component of an unactivated steroidhormone receptor complex (see FKBP2)
Enzyme Number (IUBMB): EC 5.2.1.81 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPID (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPID
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPID (NM_005038) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPID | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPID |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPID |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
PPID for ontologies About GeneDecksing
|
Pathways & Interactions
for PPID gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts | | | 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 3 | C-MYB transcription factor network | | | 4 | Calcium signaling pathway | | | 5 | Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPID
1  GeneGo (Thomson Reuters) Pathway for PPID
1  BioSystems Pathway for PPID
3 
Kegg Pathways (Kegg details for PPID):
PPID for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPID
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/153 Interacting proteins for PPID (Q087521, 2, 3 ENSP000003037544) via UniProtKB, MINT, STRING, and/or I2D (see all 153)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
PPID for ontologies About GeneDecksing
|
Drugs & Compounds
for PPID gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PPID for compounds About GeneDecksing
 Browse Tocris compounds for PPID
3 Novoseek chemical compound relationships for PPID gene About this table
Search CenterWatch for drugs/clinical trials and news about PPID
|
Transcripts
for PPID gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPID gene: NM_005038.2 Unigene Cluster for PPID: Peptidylprolyl isomerase D Hs.183958 [show with all ESTs]Unigene Representative Sequence: BC0307073 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307720(uc003iqc.3) ENST00000512699 ENST00000507213
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPID (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPID
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPID (NM_005038) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPID | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPID |
Additional cDNA sequence: AK313929.1 BC014893.1 BC030707.2 CR542081.1 L11667.1 9 DOTS entries: DT.100788240 DT.209671 DT.91677071 DT.121230040 DT.95084101 DT.100689857 DT.441522 DT.121230057 DT.92046838 24/113 AceView cDNA sequences (see all 113): AA310565 CR622611 AL546279 NM_005038 AW103753 BC014893 BM955921 BC030707 AA652422 CR596600 BM747117 AA370747 CR625064 BM697945 BU902443 BE887143 CB143325 CB990571 F25301 AI683846 BM564560 CA309987 CR542081 AI586996
GeneLoc Exon Structure
|
Expression
for PPID gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPID expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACAATACA
About this image
See PPID Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPID
SOURCE GeneReport for Unigene cluster: Hs.183958
UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including PPID:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPID
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPID | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPID | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPID | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPID |
Orthologs
for PPID gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPID gene from 9/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPID1 |
peptidylprolyl isomerase D |
76.58(n)
81.62(a) |
|
428725 XM_426283.3 XP_426283.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PPID6 |
-- |
78(a) |
1 ↔ 1 |
5(128350661-128358223) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.46432 |
Xenopus laevis, clone IMAGE5571350, mRNA |
76.06(n) |
|
BC044018.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb18b072 |
wufb18b07 |
74.19(n) |
|
321521 CA474411.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG83361 , 3 |
CG83361 |
39(a)3
47.14(n)1
41.69(a)1 |
|
67C23
391211 NM_140081.31 NP_648338.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
cyp-33 |
Peptidyl-prolyl cis-trans isomerases |
66(a)
(best of 3) |
|
V(15192351-15193440) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CPR6(YLR216C)4
CPR61 |
Peptidyl-prolyl cis-trans isomerase (cyclophilin), more4
Cpr6p1 |
53.22(n)1
46.78(a)1 |
|
12(573211-572096)4
8509141, 4 NP_013317.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SQN1 |
Peptidyl-prolyl cis-trans isomerase CYP40 |
53.35(n)
49.01(a) |
|
816074 NM_127141.3 NP_565381.1 |
rice
(Oryza sativa) |
Liliopsida |
Os06g02168001 |
hypothetical protein |
53.71(n)
49.86(a) |
|
4340493 NM_001063683.1 NP_001057148.1 |
ENSEMBL Gene Tree for PPID (if available)
TreeFam Gene Tree for PPID (if available) |
Paralogs
for PPID gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPID gene
- NKTR2 PPIG2 PPIL62
18/21 SIMAP similar genes for PPID using alignment to 5 protein entries: PPID_HUMAN (see all proteins)
(see all similar genes):PPIG PPIF DKFZp686G0426 NKTR PPIA PPIL6
PPIH PPIB PPIAL4A PPIAL4B PPIAL4C PPIAL4G
PPIE RANBP2 LOC402252 PPIC PPIL1 PPIL3
PPID for paralogs About GeneDecksing
|
Genomic Variants
for PPID gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPID |
|
Disorders
/ Diseases
for PPID gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPID for disorders About GeneDecksing
OMIM gene information: 601753
OMIM disorders: --
9  diseases for PPID: About MalaCardscolon cancer huntington's disease parkinson's disease alzheimer's disease
prostate cancer cholesterol prostatitis malaria
neuronitis
2 Novoseek disease relationships for PPID gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colon cancer |
24.6 |
1 |
15004035 (1) |
| tumors |
0 |
2 |
7906541 (1), 16397026 (1) |
Export disorders for PPID gene to outside databases
|
Publications
for PPID gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPID gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with PPID) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. (PubMed id 8509368)1, 2, 3 Kieffer L.J....Bayney R.M. (1993)
- Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. (PubMed id 11350175)1, 2, 9 Pirkl F. and Buchner J. (2001)
- The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK- positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. (PubMed id 22681779)1, 2 Pearson J.D.... Ingham R.J. (2012)
- Multiple cyclophilins involved in different cellular pathways mediate HCV replication. (PubMed id 19932913)1, 2 Gaither L.A.... Wiedmann B. (2010)
- Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling. (PubMed id 18708059)1, 2 Luu T.C....Chan W.K. (2008)
- Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. (PubMed id 15497503)1, 2 Carrello A....Ratajczak T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90. (PubMed id 12145316)1, 2 Ward B.K....Ratajczak T. (2002)
- Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. (PubMed id 11525244)1, 2 Mark P.J....Ratajczak T. (2001)
|
External Searches for PPID gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPID gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPID gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPID gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PPID | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/ppid/ | | Wikipedia | http://en.wikipedia.org/wiki/Cyclophilin |
|
| | |
About This Section
| Patent Information for PPID gene:
Search GeneIP for patents involving PPID
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPID gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PPID | | OriGene shRNA RFP for PPID | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPID | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPID | | | OriGene Protein Over-expression Lysate for PPID | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPID | | OriGene 3'-UTR Clone for PPID | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPID | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPID | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PPID | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPID | | OriGene Custom Protein Services for PPID | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPID | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPID | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPID | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPID | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPID | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPID |
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| | | | Search Tocris compounds for PPID |
| |  |  |  |  | | | | | | Recombinant Protein for PPID |
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 | | | PPID Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPID |
|  |  |  | | | | ThermoFisher Antibody for PPID |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPID |
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