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PPID Gene

protein-coding   GIFtS: 64
GCID: GC04M159630

Peptidylprolyl Isomerase D

(Previous name: peptidylprolyl isomerase D (cyclophilin D))
  See PPID-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase D1 2     Peptidylprolyl Isomerase D (Cyclophilin D)1
Cyclophilin 401 2     40 KDa Peptidyl-Prolyl Cis-Trans Isomerase D2
Cyclophilin-Related Protein2 3     Cyclophilin D2
Rotamase D2 3     cyclophilin-402
CYP-402 3     Peptidyl-Prolyl Cis-Trans Isomerase D2
CYPD2 3     40 KDa Peptidyl-Prolyl Cis-Trans Isomerase3
PPIase D2 3     CYP403
EC 5.2.1.83 8     Cyclophilin-403

External Ids:    HGNC: 92571   Entrez Gene: 54812   Ensembl: ENSG000001714977   OMIM: 6017535   UniProtKB: Q087523   

Export aliases for PPID gene to outside databases

Previous GC identifers: GC04M160480 GC04M160059 GC04M160207 GC04M159987 GC04M159849 GC04M155380


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPID Gene:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding
of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can
bind to the immunosuppressant cyclosporin A. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPID Gene:
PPID (peptidylprolyl isomerase D) is a protein-coding gene. Diseases associated with PPID include mitochondrial disorders. GO annotations related to this gene include estrogen receptor binding and transcription factor binding. An important paralog of this gene is NKTR.

UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid
receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing
distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity
control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor
complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the
nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by
promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone
activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic
lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C
virus (HCV) replication and release

Gene Wiki entry for PPID Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPID gene promoter:
         STAT1   AML1a   STAT1beta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   STAT1alpha   FOXL1   PPAR-alpha   STAT2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPID promoter sequence
   Search Chromatin IP Primers for PPID

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPID


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31.3

PPID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPID gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M159630:  view genomic region     (about GC identifiers)

Start:
159,630,279 bp from pter      End:
159,644,552 bp from pter
Size:
14,274 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase D  
Size: 370 amino acids; 40764 Da
Subunit: Identified in ESR1 or NR3C1/GCR steroid receptor-chaperone complexes. Found in HSP90 chaperone complexes
with kinase clients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1.
Interacts with HSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive
with the PPID:HSPA8 interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8
and the interaction is mutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1 and S100A2;
the interactions dissociate the PPID:HSP90AA1 interaction. Interacts with S100A6. Interacts with MYB, ILF2,
XRCC6, GNB2L1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain (DYNC1I1 or DYNC1I2)
Caution: This protein should not be confused with mitochondrial peptidyl-prolyl cis-trans isomerase F (PPIF) which
is often referred to as cyclophilin D or CypD
Secondary accessions: B2R9V2

Explore the universe of human proteins at neXtProt for PPID: NX_Q08752

Explore proteomics data for PPID at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys218, Lys283, Lys341
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPID (Q08752) (see all 14)
     PKTAENF  GLLSMAN  FMIQGGD  GGESIYG 


    See PPID Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005029.1  
    ENSEMBL proteins: 
     ENSP00000303754   ENSP00000423207   ENSP00000421221  

    PPID Human Recombinant Protein Products:

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    Novus Biologicals PPID Proteins
    Novus Biologicals PPID Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPID
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PPID 

     
    antibodies-online proteins for PPID (13 products) 

     
    antibodies-online peptides for PPID

    PPID Antibody Products:

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    antibodies-online antibodies for PPID (3 products) 

    PPID Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPID 
    antibodies-online kits for PPID (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR020892 Cyclophilin-type_PPIase_CS
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q08752

    ProtoNet protein and cluster: Q08752

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase D subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with PPID           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPID_HUMAN, Q08752
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid
    receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing
    distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity
    control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor
    complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the
    nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by
    promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone
    activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic
    lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C
    virus (HCV) replication and release
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Less sensitive to inhibition by cyclosporin A than is CYP-18

         Genatlas biochemistry entry for PPID:
    cyclophilin 40kDa,with intrinsic peptidyl-prolyl cis-trans isomerase activity,component of an unactivated steroid
    hormone receptor complex (see FKBP2)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA11350175
    GO:0005515protein binding IPI16507998
    GO:0008134transcription factor binding IDA9659917
    GO:0016018cyclosporin A binding TAS7744028
    GO:0030331estrogen receptor binding ISS--
         
    Find genes that share ontologies with PPID           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PPID

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPID:
    hsa-mir-30a-5p (MIRT028395), hsa-let-7b-5p (MIRT032229)

    Block miRNA regulation of human, mouse, rat PPID using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PPID:
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-548p hsa-miR-30d hsa-miR-30a hsa-miR-548g hsa-miR-30b hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidPPID 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPID
    Predesigned siRNA for gene silencing in human, mouse, rat PPID

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPID

    Clone
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    OriGene ORF clones in mouse, rat for PPID
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPID (NM_005038)
    Sino Biological Human cDNA Clone for PPID
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPID
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPID

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPID


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPID_HUMAN, Q08752: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0045111intermediate filament cytoskeleton ----

    Find genes that share ontologies with PPID           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPID About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Cellular Apoptosis Pathway0.85
    2COPI Mediated Transport
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    3C-MYB transcription factor network
    C-MYB transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPID
        Mitochondrial Apoptosis
    Cellular Apoptosis Pathway

    1 GeneGo (Thomson Reuters) Pathway for PPID
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)

    1 BioSystems Pathway for PPID
        C-MYB transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPID: 
              Parkinson's Disease in human mouse rat
              Necrosis in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPID

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPID (Q087521, 2, 3 ENSP000003037544) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253550 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253550 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253550 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253550 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253550 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP18708059
    GO:0000413protein peptidyl-prolyl isomerization IDA11350175
    GO:0006457protein folding ISS--
    GO:0006461protein complex assembly IDA18708059
    GO:0006915apoptotic process IEA--

    Find genes that share ontologies with PPID           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPID

    3 Novoseek inferred chemical compound relationships for PPID gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclosporin a 59.3 10 20023700 (3), 7546642 (2), 7476967 (1), 7717993 (1) (see all 5)
    tacrolimus 58.3 4 20023700 (3)
    steroid 38.2 1 7546642 (1)



    Find genes that share compounds with PPID           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPID gene: 
    NM_005038.2  

    Unigene Cluster for PPID:

    Peptidylprolyl isomerase D
    Hs.183958  [show with all ESTs]
    Unigene Representative Sequence: BC030707
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307720(uc003iqc.3) ENST00000512699 ENST00000507213
    miRNA
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    Block miRNA regulation of human, mouse, rat PPID using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PPID:
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-548p hsa-miR-30d hsa-miR-30a hsa-miR-548g hsa-miR-30b hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidPPID 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPID
      QuantiTect SYBR Green Assays in human, mouse, rat PPID
      QuantiFast Probe-based Assays in human, mouse, rat PPID

    Additional mRNA sequence: 

    AK313929.1 BC014893.1 BC030707.2 CR542081.1 L11667.1 

    9 DOTS entries:

    DT.100788240  DT.209671  DT.91677071  DT.121230040  DT.95084101  DT.100689857  DT.441522  DT.121230057 
    DT.92046838 

    Selected AceView cDNA sequences (see all 113):

    CR542081 AL546279 AA370747 AW103753 CA309987 BC030707 BM955921 CR622611 
    BC014893 AI586996 BM747117 CB143325 BM564560 AA310565 NM_005038 CB990571 
    CR625064 AA652422 AI457867 BE887143 CR596600 AI683846 BU902443 F25301 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPID expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACAATACA
    PPID Expression
    About this image


    PPID expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PPID Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPID Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183958

    UniProtKB/Swiss-Prot: PPID_HUMAN, Q08752
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPID: 
              Parkinson's Disease in human mouse rat
              Necrosis in human mouse rat
              Cellular Stress Responses in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPID
    OriGene qSTAR qPCR primer pairs in human, mouse for PPID
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPID
    QuantiTect SYBR Green Assays in human, mouse, rat PPID
    QuantiFast Probe-based Assays in human, mouse, rat PPID
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPID

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPID gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppid1 , 5 peptidylprolyl isomerase D (cyclophilin D)1, 5 90.45(n)1
    94.32(a)1
      3 (34.91 cM)5
    677381  NM_026352.31  NP_080628.11 
     795913425 
    chicken
    (Gallus gallus)
    Aves PPID1 peptidylprolyl isomerase D 76.58(n)
    81.62(a)
      428725  XM_426283.4  XP_426283.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPID6
    peptidylprolyl isomerase D
    78(a)
    1 ↔ 1
    5(128350661-128358223)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46432 Xenopus laevis, clone IMAGE5571350, mRNA 76.06(n)    BC044018.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb18b072 wufb18b07 74.19(n)   321521  CA474411.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83361 , 3 CG83361 39(a)3
    47.23(n)1
    41.69(a)1
      67C23
    391211  NM_001274707.11  NP_001261636.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR6(YLR216C)4
    CPR61
    Peptidyl-prolyl cis-trans isomerase (cyclophilin), more4
    CPR61
    53.41(n)1
    48.3(a)1
      12(573211-572096)4
    8509141, 4  NP_013317.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SQN1 SQN 53.98(n)
    50(a)
      816074  NM_127141.3  NP_565381.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02168001 Os06g0216800 53.06(n)
    49.04(a)
      4340493  NM_001063683.1  NP_001057148.1 


    ENSEMBL Gene Tree for PPID (if available)
    TreeFam Gene Tree for PPID (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPID gene
    NKTR2  PPIG2  PPIL62  
    Selected SIMAP similar genes for PPID using alignment to 5 protein entries:     PPID_HUMAN (see all proteins) (see all similar genes):
    PPIG    PPIF    DKFZp686G0426    NKTR    PPIA    PPIL6
    PPIH    PPIB    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G
    PPIE    PPIAL4D    RANBP2    LOC402252    PPIC    PPIL1

    Find genes that share paralogs with PPID           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PPID (see all 380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379460571,2
    C--159630401(+) TTGGCC/TGGGCA 1 -- ut310--------
    rs178439631,2
    C,F--159630535(-) AGCTAA/CTTTTT 1 -- ut311Minor allele frequency- C:0.02NS 180
    rs1892643011,2
    --159630633(+) GAGCCA/GAGATT 1 -- ut310--------
    rs754904631,2
    C--159630634(+) AGCCGA/GGATTG 1 -- ut310--------
    rs178439621,2
    C,F--159630641(-) GGTGGC/TGCAAT 1 -- ut311Minor allele frequency- T:0.01NS 178
    rs83961,2
    C,F,O,H--159630817(-) TGTCTA/GTGAAT 1 -- ut3129Minor allele frequency- G:0.29MN NS EA NA WA CSA 3528
    rs617481701,2
    C,F--159630924(+) TCTTTA/GTCTTT 2 D syn12Minor allele frequency- G:0.00NA EU 5833
    rs1482652691,2
    --159631205(+) CTCTAC/TATTAG 1 -- int10--------
    rs748788021,2
    C,F--159631232(+) CCCTTG/ATTTCA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs178439591,2
    C--159631265(-) TTACAA/GAATGT 1 -- int12Minor allele frequency- G:0.01NS NA 178

    HapMap Linkage Disequilibrium report for PPID (159630279 - 159644552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPID:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830125CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPID
    DNA2.0 Custom Variant and Variant Library Synthesis for PPID

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601753    OMIM disorders: --

    1 disease for PPID:    
    About MalaCards
    mitochondrial disorders


    Find genes that share disorders with PPID           About GenesLikeMe

    2 Novoseek inferred disease relationships for PPID gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 24.6 1 15004035 (1)
    tumors 0 2 7906541 (1), 16397026 (1)

    Genetic Association Database (GAD): PPID

    Export disorders for PPID gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPID gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with PPID)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. (PubMed id 8509368)1, 2, 3 Kieffer L.J....Bayney R.M. (J. Biol. Chem. 1993)
    2. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. (PubMed id 11350175)1, 2, 9 Pirkl F. and Buchner J. (J. Mol. Biol. 2001)
    3. The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK- positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. (PubMed id 22681779)1, 2 Pearson J.D.... Ingham R.J. (BMC Cancer 2012)
    4. Human metabolic individuality in biomedical and pharmaceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (Nature 2011)
    5. Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. (PubMed id 21146485)1, 2 Park M.S.... Chan W.K. (Anal. Biochem. 2011)
    6. Multiple cyclophilins involved in different cellular pathways mediate HCV replication. (PubMed id 19932913)1, 2 Gaither L.A.... Wiedmann B. (Virology 2010)
    7. A genome-wide perspective of genetic variation in human metabolism. (PubMed id 20037589)1, 4 Illig T....Suhre K. (Nat. Genet. 2010)
    8. Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling. (PubMed id 18708059)1, 2 Luu T.C.... Chan W.K. (FEBS Lett. 2008)
    9. Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. (PubMed id 15497503)1, 2 Carrello A.... Ratajczak T. (Cell Stress Chaperones 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5481 HGNC: 9257 AceView: PPID Ensembl:ENSG00000171497 euGenes: HUgn5481
    ECgene: PPID H-InvDB: PPID

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPID Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppid/
    Wikipedia http://en.wikipedia.org/wiki/Cyclophilin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPID gene:
    Search GeneIP for patents involving PPID

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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