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Aliases for PPID Gene

Aliases for PPID Gene

  • Peptidylprolyl Isomerase D 2 3 5
  • Cyclophilin-Related Protein 3 4
  • Cyclophilin 40 2 3
  • Rotamase D 3 4
  • EC 5.2.1.8 4 61
  • PPIase D 3 4
  • CYP-40 3 4
  • CYPD 3 4
  • 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase D 3
  • Peptidylprolyl Isomerase D (Cyclophilin D) 2
  • 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase 4
  • Peptidyl-Prolyl Cis-Trans Isomerase D 3
  • Testicular Tissue Protein Li 147 3
  • Cyclophilin-40 4
  • Cyclophilin D 3
  • CYP40 4

External Ids for PPID Gene

Previous GeneCards Identifiers for PPID Gene

  • GC04M160480
  • GC04M160059
  • GC04M160207
  • GC04M159987
  • GC04M159849
  • GC04M159630
  • GC04M155380

Summaries for PPID Gene

Entrez Gene Summary for PPID Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPID Gene

PPID (Peptidylprolyl Isomerase D) is a Protein Coding gene. Among its related pathways are C-MYB transcription factor network and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include transcription factor binding and heat shock protein binding. An important paralog of this gene is PPIG.

UniProtKB/Swiss-Prot for PPID Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Gene Wiki entry for PPID Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPID Gene

Genomics for PPID Gene

Regulatory Elements for PPID Gene

Enhancers for PPID Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G158808 2 FANTOM5 Ensembl ENCODE dbSUPER 18.2 -88.4 -88430 7.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 WRNIP1 FEZF1 YBX1 ZNF2 YY1 FNIP2 PPID ETFDH RAPGEF2 GC04M158795 RNU6-128P GC04P158864
GH04G158823 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -102.5 -102468 5.7 HDGF PKNOX1 FOXA2 ATF1 MLX FEZF1 TCF12 SLC30A9 GATA2 SP5 FNIP2 PPID RNU6-128P ETFDH C4orf45 RAPGEF2 GC04M158795 GC04P158864
GH04G158819 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -97.6 -97642 3.1 ELF3 FOXA2 MLX FEZF1 ZSCAN9 RARA GATA4 SCRT2 RELB IKZF2 FNIP2 PPID RNU6-128P ETFDH C4orf45 RAPGEF2 GC04M158795 GC04P158864
GH04G158781 1.5 Ensembl ENCODE dbSUPER 15.8 -59.7 -59686 2.6 PKNOX1 FOXA2 ARNT ARID4B FEZF1 ZNF2 YY1 GATA2 FOS REST PPID FNIP2 C4orf45 RAPGEF2 GC04M158750 RNU6-128P GC04M158795
GH04G158817 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -94.7 -94701 2.2 SOX5 MTA2 BHLHE40 NR2F1 CEBPG TBX21 RARA ARID1B RAD51 CEBPA FNIP2 PPID RNU6-128P RAPGEF2 GC04M158795 GC04P158864
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPID on UCSC Golden Path with GeneCards custom track

Promoters for PPID Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000175459 400 2001 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for PPID Gene

Chromosome:
4
Start:
158,709,127 bp from pter
End:
158,723,400 bp from pter
Size:
14,274 bases
Orientation:
Minus strand

Genomic View for PPID Gene

Genes around PPID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPID Gene

Proteins for PPID Gene

  • Protein details for PPID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08752-PPID_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase D
    Protein Accession:
    Q08752
    Secondary Accessions:
    • B2R9V2

    Protein attributes for PPID Gene

    Size:
    370 amino acids
    Molecular mass:
    40764 Da
    Quaternary structure:
    • Identified in ESR1 or NR3C1/GCR steroid receptor-chaperone complexes. Found in HSP90 chaperone complexes with kinase clients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1. Interacts with HSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive with the PPID:HSPA8 interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8 and the interaction is mutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1 and S100A2; the interactions dissociate the PPID:HSP90AA1 interaction. Interacts with S100A6. Interacts with MYB, ILF2, XRCC6, RACK1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain (DYNC1I1 or DYNC1I2).

neXtProt entry for PPID Gene

Selected DME Specific Peptides for PPID Gene

Q08752:
  • GLLSMAN
  • FMIQGGD
  • LSMANAG
  • NGSQFFITTV
  • KFEDENF
  • TNGSQFF
  • TAENFRAL
  • KHVVFGQV
  • SIYGEKF
  • ALSCVLNIGACKLKMS
  • PKTAENF
  • LDGKHVVFG
  • GGESIYG
  • LCTGEKG

Post-translational modifications for PPID Gene

  • Ubiquitination at posLast=218218, posLast=283283, and Lys341
  • Modification sites at PhosphoSitePlus

Other Protein References for PPID Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PPID Gene

Suggested Antigen Peptide Sequences for PPID Gene

Graphical View of Domain Structure for InterPro Entry

Q08752

UniProtKB/Swiss-Prot:

PPID_HUMAN :
  • Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
genes like me logo Genes that share domains with PPID: view

Function for PPID Gene

Molecular function for PPID Gene

GENATLAS Biochemistry:
cyclophilin 40kDa,with intrinsic peptidyl-prolyl cis-trans isomerase activity,component of an unactivated steroid hormone receptor complex (see FKBP2)
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Less sensitive to inhibition by cyclosporin A than is CYP-18.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Enzyme Numbers (IUBMB) for PPID Gene

Gene Ontology (GO) - Molecular Function for PPID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 11350175
GO:0005515 protein binding IPI 9659917
GO:0008134 transcription factor binding IDA 9659917
GO:0016018 cyclosporin A binding TAS 7744028
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPID: view
genes like me logo Genes that share phenotypes with PPID: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PPID

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPID Gene

Localization for PPID Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPID Gene

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPID gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11525244
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA,IDA 11525244
GO:0005737 cytoplasm IDA,IEA 11525244
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PPID: view

Pathways & Interactions for PPID Gene

genes like me logo Genes that share pathways with PPID: view

Pathways by source for PPID Gene

Gene Ontology (GO) - Biological Process for PPID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18708059
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding ISS --
GO:0006461 protein complex assembly IDA 18708059
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with PPID: view

No data available for SIGNOR curated interactions for PPID Gene

Drugs & Compounds for PPID Gene

(2) Drugs for PPID Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PPID Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPID: view

Transcripts for PPID Gene

mRNA/cDNA for PPID Gene

Unigene Clusters for PPID Gene

Peptidylprolyl isomerase D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPID Gene

No ASD Table

Relevant External Links for PPID Gene

GeneLoc Exon Structure for
PPID
ECgene alternative splicing isoforms for
PPID

Expression for PPID Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPID Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPID Gene



Protein tissue co-expression partners for PPID Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPID Gene:

PPID

SOURCE GeneReport for Unigene cluster for PPID Gene:

Hs.183958

mRNA Expression by UniProt/SwissProt for PPID Gene:

Q08752-PPID_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PPID Gene

  • Blood(4.4)
  • Liver(4.4)
  • Nervous system(4.4)
  • Pancreas(4.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with PPID: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPID Gene

Orthologs for PPID Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPID 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia PPID 34 35
  • 92.97 (n)
rat
(Rattus norvegicus)
Mammalia Ppid 34
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Ppid 34 16 35
  • 90.45 (n)
cow
(Bos Taurus)
Mammalia PPID 34 35
  • 90 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPID 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPID 34 35
  • 76.58 (n)
lizard
(Anolis carolinensis)
Reptilia PPID 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppid 34
  • 73.42 (n)
MGC75854 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4643 34
zebrafish
(Danio rerio)
Actinopterygii ppid 34 35
  • 67.66 (n)
wufb18b07 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003265 34
  • 47.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8336 36 34 35
  • 47.23 (n)
worm
(Caenorhabditis elegans)
Secernentea cyp-3 36
  • 66 (a)
cyp-7 36
  • 62 (a)
cyp-8 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 34 35 37
  • 53.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05093g 34
  • 52.94 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR087C 34
  • 46.8 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SQN 34
  • 53.98 (n)
rice
(Oryza sativa)
Liliopsida Os06g0216800 34
  • 53.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes wis2 34
  • 53.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03853 34
  • 53.62 (n)
Species where no ortholog for PPID was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPID Gene

ENSEMBL:
Gene Tree for PPID (if available)
TreeFam:
Gene Tree for PPID (if available)

Paralogs for PPID Gene

Paralogs for PPID Gene

genes like me logo Genes that share paralogs with PPID: view

Variants for PPID Gene

Sequence variations from dbSNP and Humsavar for PPID Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17843966 Benign 158,708,662(-) TATAG(G/T)ATAAA downstream-variant-500B, utr-variant-3-prime
rs1000035951 -- 158,714,926(+) ACTTT(A/G)GGGTG intron-variant
rs1000114774 -- 158,720,751(+) ACTCT(A/G)TCGCC intron-variant
rs1001116968 -- 158,708,802(+) CATTT(A/G)ACTTG downstream-variant-500B
rs1001686275 -- 158,712,957(+) GAATG(C/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPID Gene

Variant ID Type Subtype PubMed ID
nsv830125 CNV gain 17160897

Variation tolerance for PPID Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.51; 88.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPID Gene

Disorders for PPID Gene

Relevant External Links for PPID

Genetic Association Database (GAD)
PPID
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPID

No disorders were found for PPID Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPID Gene

Publications for PPID Gene

  1. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. (PMID: 11350175) Pirkl F. … Buchner J. (J. Mol. Biol. 2001) 3 4 22 64
  2. Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. (PMID: 8509368) Kieffer L.J. … Bayney R.M. (J. Biol. Chem. 1993) 2 3 4 64
  3. Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes. (PMID: 23220213) Jandova J. … Sligh J.E. (Exp. Cell Res. 2013) 3 4 64
  4. The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK- positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. (PMID: 22681779) Pearson J.D. … Ingham R.J. (BMC Cancer 2012) 3 4 64
  5. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K. … Gieger C. (Nature 2011) 3 46 64

Products for PPID Gene

Sources for PPID Gene

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