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Aliases for PPIC Gene

Aliases for PPIC Gene

  • Peptidylprolyl Isomerase C 2 3
  • Cyclophilin C 2 3 4
  • Peptidylprolyl Isomerase C (Cyclophilin C) 3 5
  • Rotamase C 3 4
  • EC 5.2.1.8 4 63
  • PPIase C 3 4
  • CYPC 3 4
  • Parvulin 3

External Ids for PPIC Gene

Previous GeneCards Identifiers for PPIC Gene

  • GC05M121989
  • GC05M122686
  • GC05M122389
  • GC05M122435
  • GC05M122386
  • GC05M117547
  • GC05M122363

Summaries for PPIC Gene

Entrez Gene Summary for PPIC Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIC Gene

PPIC (Peptidylprolyl Isomerase C) is a Protein Coding gene. Diseases associated with PPIC include disseminated intravascular coagulation. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIC Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIC Gene

Genomics for PPIC Gene

Regulatory Elements for PPIC Gene

Enhancers for PPIC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIC on UCSC Golden Path with GeneCards custom track

Promoters for PPIC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIC on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIC Gene

Chromosome:
5
Start:
123,023,250 bp from pter
End:
123,036,741 bp from pter
Size:
13,492 bases
Orientation:
Minus strand

Genomic View for PPIC Gene

Genes around PPIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIC Gene

Proteins for PPIC Gene

  • Protein details for PPIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45877-PPIC_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase C
    Protein Accession:
    P45877
    Secondary Accessions:
    • A4LBB5

    Protein attributes for PPIC Gene

    Size:
    212 amino acids
    Molecular mass:
    22763 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PPIC Gene

neXtProt entry for PPIC Gene

Proteomics data for PPIC Gene at MOPED

Selected DME Specific Peptides for PPIC Gene

Post-translational modifications for PPIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIC Gene

Gene Families for PPIC Gene

Suggested Antigen Peptide Sequences for PPIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P45877

UniProtKB/Swiss-Prot:

PPIC_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIC: view

Function for PPIC Gene

Molecular function for PPIC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cyclosporin A (CsA) inhibits CYPC.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIC Gene

Gene Ontology (GO) - Molecular Function for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with PPIC: view

Phenotypes for PPIC Gene

genes like me logo Genes that share phenotypes with PPIC: view

Animal Model Products

miRNA for PPIC Gene

miRTarBase miRNAs that target PPIC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIC Gene

Localization for PPIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIC Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIC Gene COMPARTMENTS Subcellular localization image for PPIC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPIC: view

Pathways & Interactions for PPIC Gene

SuperPathways for PPIC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIC: view

No data available for Pathways by source and SIGNOR curated interactions for PPIC Gene

Drugs & Compounds for PPIC Gene

(5) Drugs for PPIC Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPIC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPIC Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
genes like me logo Genes that share compounds with PPIC: view

Transcripts for PPIC Gene

mRNA/cDNA for PPIC Gene

Unigene Clusters for PPIC Gene

Peptidylprolyl isomerase C (cyclophilin C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for PPIC Gene

GeneLoc Exon Structure for
PPIC
ECgene alternative splicing isoforms for
PPIC

Expression for PPIC Gene

mRNA expression in normal human tissues for PPIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIC Gene

This gene is overexpressed in Bone marrow stromal cell (10.4), Milk (9.1), and Synovial fluid (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIC Gene



SOURCE GeneReport for Unigene cluster for PPIC Gene Hs.110364

genes like me logo Genes that share expression patterns with PPIC: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPIC Gene

Orthologs for PPIC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPIC 35
  • 89.62 (n)
  • 92.92 (a)
PPIC 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIC 35
  • 84.69 (n)
  • 86.22 (a)
PPIC 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppic 35
  • 86.32 (n)
  • 90.57 (a)
Ppic 16
Ppic 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPIC 35
  • 99.06 (n)
  • 98.11 (a)
PPIC 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppic 35
  • 84.75 (n)
  • 87.26 (a)
oppossum
(Monodelphis domestica)
Mammalia PPIC 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIC 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIC 35
  • 74.83 (n)
  • 80.61 (a)
PPIC 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIC 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppic 35
  • 72.5 (n)
  • 77.5 (a)
Str.20449 35
zebrafish
(Danio rerio)
Actinopterygii LOC100333141 35
  • 68.54 (n)
  • 70.92 (a)
PPIC 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2852 37
  • 66 (a)
ninaA 37
  • 51 (a)
CG2852 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-5 37
  • 66 (a)
cyp-6 37
  • 67 (a)
cyn-5 36
  • 62 (a)
ManyToMany
cyn-6 36
  • 63 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 35
  • 58.69 (n)
  • 60.12 (a)
CPR2 36
  • 50 (a)
ManyToMany
CPR5 36
  • 44 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC4 35
  • 65.24 (n)
  • 66.46 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7094 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5529 36
  • 60 (a)
OneToMany
Species with no ortholog for PPIC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIC Gene

ENSEMBL:
Gene Tree for PPIC (if available)
TreeFam:
Gene Tree for PPIC (if available)

Paralogs for PPIC Gene

Paralogs for PPIC Gene

(22) SIMAP similar genes for PPIC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIC: view

Variants for PPIC Gene

Sequence variations from dbSNP and Humsavar for PPIC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_024319 -
VAR_051770 -
VAR_060712 -
rs10076327 -- 123,031,652(+) GAATA(A/G)GGTCA intron-variant
rs10455038 -- 123,032,381(+) GTTAA(C/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIC Gene

Variant ID Type Subtype PubMed ID
nsv520349 CNV Loss 19592680

Variation tolerance for PPIC Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIC Gene

HapMap Linkage Disequilibrium report
PPIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIC Gene

Disorders for PPIC Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPIC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
disseminated intravascular coagulation
  • defibrination syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PPIC in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPIC

Genetic Association Database (GAD)
PPIC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIC
genes like me logo Genes that share disorders with PPIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIC Gene

Publications for PPIC Gene

  1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PMID: 8031755) Schneider H. … Movva N.R. (Biochemistry 1994) 2 3 4 23 67
  2. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PMID: 1383094) Sugano S. … Yamaguchi N. (Gene 1992) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis. (PMID: 24990953) Stocki P. … Williams D.B. (J. Biol. Chem. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PPIC Gene

Sources for PPIC Gene

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