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PPIC Gene

protein-coding   GIFtS: 57
GCID: GC05M122363

Peptidylprolyl Isomerase C (Cyclophilin C)

  See PPIC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase C (Cyclophilin C)1 2     PPIase C2 3
Cyclophilin C2 3     EC 5.2.1.83 8
Rotamase C2 3     parvulin2
CYPC2 3     Peptidyl-Prolyl Cis-Trans Isomerase C2

External Ids:    HGNC: 92561   Entrez Gene: 54802   Ensembl: ENSG000001689387   OMIM: 1238425   UniProtKB: P458773   

Export aliases for PPIC gene to outside databases

Previous GC identifers: GC05M121989 GC05M122686 GC05M122389 GC05M122435 GC05M122386 GC05M117547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPIC Gene:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding
of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PPIC Gene:
PPIC (peptidylprolyl isomerase C (cyclophilin C)) is a protein-coding gene. Diseases associated with PPIC include acute promyelocytic leukemia. GO annotations related to this gene include unfolded protein binding and cyclosporin A binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIC gene promoter:
         NF-YB   SRY   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIC promoter sequence
   Search Chromatin IP Primers for PPIC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

PPIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIC gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M122363:  view genomic region     (about GC identifiers)

Start:
122,358,945 bp from pter      End:
122,372,436 bp from pter
Size:
13,492 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase C  
Size: 212 amino acids; 22763 Da
1 PDB 3D structure from and Proteopedia for PPIC:
2ESL (3D)    
Secondary accessions: A4LBB5

Explore the universe of human proteins at neXtProt for PPIC: NX_P45877

Explore proteomics data for PPIC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIC (P45877) (see all 7)
     FMIQGGD  PKTVENF  KGSKFHR  TNGSQFF 


    See PPIC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000934.1  
    ENSEMBL proteins: 
     ENSP00000303057  

    PPIC Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PPIC

     
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    antibodies-online proteins for PPIC (8 products) 

     
    antibodies-online peptides for PPIC

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P45877

    ProtoNet protein and cluster: P45877

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
    Similarity: Belongs to the cyclophilin-type PPIase family
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Find genes that share domains with PPIC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIC_HUMAN, P45877
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPC

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding ----
    GO:0016018cyclosporin A binding TAS1652374
    GO:0051082unfolded protein binding TAS1652374
         
    Find genes that share ontologies with PPIC           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Ppic (no phenotypes)

    Find genes that share phenotypes with PPIC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppictm1Jsf for PPIC

       genOway: Develop your customized and physiologically relevant rodent model for PPIC

    miRNA
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    miRTarBase miRNAs that target PPIC:
    hsa-mir-26b-5p (MIRT030019)

    Block miRNA regulation of human, mouse, rat PPIC using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PPIC:
    hsa-miR-204 hsa-miR-889 hsa-miR-29a hsa-miR-29c hsa-miR-548l hsa-miR-211 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidPPIC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPIC

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    Addgene plasmids for PPIC 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIC_HUMAN, P45877: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PPIC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIC
    Interactions:

        GeneGlobe Interaction Network for PPIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPIC (P458772, 3 ENSP000003030574) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861888 I2D: score=3 STRING: ENSP00000357292
    LGALS3BPQ083803, ENSP000002627764I2D: score=1 STRING: ENSP00000262776
    IDNKENSP000002771244STRING: ENSP00000277124
    RAD21ENSP000002973384STRING: ENSP00000297338
    RAD21L1ENSP000003864144STRING: ENSP00000386414
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0007165signal transduction TAS1652374

    Find genes that share ontologies with PPIC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIC

    1 DrugBank Compound for PPIC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    6 Novoseek inferred chemical compound relationships for PPIC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juglone 82.1 8 9558330 (3), 18539601 (1)
    tacrolimus 50.6 5 9558330 (1), 16610367 (1), 10966874 (1), 14977579 (1)
    fibrinogen 49 8 9282795 (3), 9701463 (1), 12643327 (1), 10695769 (1) (see all 5)
    cyclosporin a 48.1 13 8265636 (5), 8031755 (4), 9558330 (1), 7546642 (1)
    ptca 26 1 10440909 (1)
    warfarin 17.8 1 10695769 (1)



    Find genes that share compounds with PPIC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPIC gene: 
    NM_000943.4  

    Unigene Cluster for PPIC:

    Peptidylprolyl isomerase C (cyclophilin C)
    Hs.110364  [show with all ESTs]
    Unigene Representative Sequence: AK290321
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306442(uc003kth.3) ENST00000415659(uc011cwp.1)
    miRNA
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    hsa-miR-204 hsa-miR-889 hsa-miR-29a hsa-miR-29c hsa-miR-548l hsa-miR-211 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidPPIC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPIC
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    GenScript: all cDNA clones in your preferred vector: PPIC (NM_000943)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIC
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      QuantiTect SYBR Green Assays in human, mouse, rat PPIC
      QuantiFast Probe-based Assays in human, mouse, rat PPIC

    Additional mRNA sequence: 

    AK290321.1 AK304053.1 BC002678.2 L04460.1 S71018.1 

    5 DOTS entries:

    DT.100744754  DT.97807000  DT.99936478  DT.111742  DT.91712722 

    Selected AceView cDNA sequences (see all 103):

    BM833458 BX093499 NM_000943 CR592786 BQ084414 BU580927 AL711077 CA488493 
    H88002 T91633 BE379145 AA569906 BX472017 BE613005 BU857023 BM822723 
    CA419624 AI654663 BI962501 BI838731 BI825305 AL540607 BU569616 BQ304081 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPIC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                          -           -     -                     
    SP2:                          -     -           -                     
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for PPIC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCGTCCACT
    PPIC Expression
    About this image


    PPIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    PPIC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.110364
        Custom PCR Arrays for PPIC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIC gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppic1 , 5 peptidylprolyl isomerase C1, 5 86.32(n)1
    90.57(a)1
      18 (29.03 cM)5
    190381  NM_008908.41  NP_032934.11 
     534063415 
    chicken
    (Gallus gallus)
    Aves PPIC1 peptidylprolyl isomerase C (cyclophilin C) 74.83(n)
    80.61(a)
      768427  XM_001231332.3  XP_001231333.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPIC6
    peptidylprolyl isomerase C (cyclophilin C)
    78(a)
    1 ↔ 1
    GL343193.1(12285982-12297130)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204492 Transcribed sequence with moderate similarity to protein more 79.58(n)    AL896133.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003331411 peptidyl-prolyl cis-trans isomerase C-like 68.54(n)
    70.92(a)
      100333141  XM_002667830.3  XP_002667876.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28523 peptidyl-prolyl cis-trans isomerase 66(a)
    (best of 2)
      58F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-63 Expression: intestine, embryo, L1
    larva, L2 larva
    67(a)
    (best of 2)
      III(773386-774204)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR21 CPR2 58.69(n)
    60.12(a)
      856454   NP_011924.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ROC41 ROC4 65.24(n)
    66.46(a)
      825376  NM_001203230.1  NP_001190159.1 


    ENSEMBL Gene Tree for PPIC (if available)
    TreeFam Gene Tree for PPIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIC gene
    PPIH2  PPIB2  CWC272  PPWD12  PPIL42  PPIL22  PPIL32  PPIL12  
    Selected SIMAP similar genes for PPIC using alignment to 1 protein entry:     PPIC_HUMAN(see all similar genes):
    PPIB    PPIA    PPIF    PPIE    PPIAL4A    PPIAL4B
    PPIAL4C    PPIAL4G    PPIL1    RANBP2    PPIAL4D    PPIH
    LOC402252    PPID    PPIG    PPIL6    NKTR    PPIL3

    Find genes that share paralogs with PPIC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIC (see all 320)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21697731,2
    C,F,A--122358601(+) TCAAGC/AAATCC 1 -- ds50014Minor allele frequency- A:0.18NS NA CSA 160
    rs1391267591,2
    --122358619(+) TCAGCC/GTCCTG 1 -- ds50010--------
    rs4015351,2
    C,F,A--122358685(+) GAGACA/GGGGTC 1 -- ds50016Minor allele frequency- G:0.16NS NA CSA WA EA 518
    rs1848687931,2
    --122358848(+) CCTATA/TGCAAC 1 -- ds50010--------
    rs100540271,2
    C,F,A--122358935(+) GGATGG/AGCATA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs354135551,2
    C,F--122359003(+) TCACTG/ATTAAT 1 -- ds50015Minor allele frequency- A:0.02NA NS 290
    rs767398891,2
    C--122359010(+) TAATGA/CTAGAG 1 -- ds50010--------
    rs455619351,2
    C,F--122359085(-) ACTTTT/CAGATC 1 -- ut312Minor allele frequency- C:0.03NS WA 274
    rs155771,2
    C,F,O,A,H--122359190(+) TTTCTG/TTTTGG 1 -- ut3122Minor allele frequency- T:0.21MN NA NS EA CSA WA 2580
    rs455609341,2
    C,F--122359243(-) TGGGTA/GATGCT 1 -- ut312Minor allele frequency- G:0.03NS WA 288

    HapMap Linkage Disequilibrium report for PPIC (122358945 - 122372436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPIC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520349CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIC
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123842    OMIM disorders: --

    1 disease for PPIC:    
    About MalaCards
    acute promyelocytic leukemia


    Find genes that share disorders with PPIC           About GenesLikeMe

    1 Novoseek inferred disease relationship for PPIC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    disseminated intravascular coagulation 72.7 1 10805276 (1)

    Genetic Association Database (GAD): PPIC

    Export disorders for PPIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIC gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with PPIC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PubMed id 8031755)1, 2, 3, 9 Schneider H.... Movva N.R. (Biochemistry 1994)
    2. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (JAMA 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PubMed id 1383094)1, 3 Sugano S....Yamaguchi N. (Gene 1992)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5480 HGNC: 9256 AceView: PPIC Ensembl:ENSG00000168938 euGenes: HUgn5480
    ECgene: PPIC H-InvDB: PPIC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPIC Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppic/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPIC gene:
    Search GeneIP for patents involving PPIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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