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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIC Gene

protein-coding   GIFtS: 55
GCID: GC05M122363

peptidylprolyl isomerase C (cyclophilin C)
 Explore 11 diseases affiliated with
PPIC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPIC    

Aliases
for PPIC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Peptidylprolyl Isomerase C (Cyclophilin C)1 2     PPIase C2 3
CYPC1 2 3     EC 5.2.1.83 8
Cyclophilin C2 3     Parvulin1
Rotamase C2 3     Peptidyl-Prolyl Cis-Trans Isomerase C2

External Ids:    HGNC: 92561   Entrez Gene: 54802   Ensembl: ENSG000001689387   OMIM: 1238425   UniProtKB: P458773   

Export aliases for PPIC gene to outside databases

Previous GC identifers: GC05M121989 GC05M122686 GC05M122389 GC05M122435 GC05M122386 GC05M117547


Summaries
for PPIC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPIC:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of
proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIC


Genomic Views
for PPIC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIC gene promoter:
         NF-YB   SRY   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPIC promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

PPIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIC gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M122363:  view genomic region     (about GC identifiers)

Start:
 122,358,945 bp from pter      End:
 122,372,436 bp from pter
Size:
 13,492 bases      Orientation:
 minus strand

Proteins
for PPIC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase C  
Size: 212 amino acids; 22763 Da
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for PPIC:
2ESL (3D)    
Secondary accessions: A4LBB5

Explore the universe of human proteins at neXtProt for PPIC: NX_P45877

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P45877

    • 4/7 DME Specific Peptides for PPIC (P45877) (see all 7)
     FMIQGGD  PKTVENF  KGSKFHR  TNGSQFF 

    PPIC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000934.1  
    ENSEMBL proteins: 
     ENSP00000303057  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals PPIC Protein
    Novus Biologicals PPIC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PPIC

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    PPIC for ontologies           About GeneDecksing



    PPIC Antibody Products: 
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    Uscn ELISAs and CLIAs for PPIC

    Protein Domains /
    Families
    for PPIC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPIC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P45877

    ProtoNet protein and cluster: P45877

    1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
    Similarity: Belongs to the cyclophilin-type PPIase family
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Function
    for PPIC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPC

    Enzyme Number (IUBMB): EC 5.2.1.81 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PPIC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIC
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIC:
    hsa-miR-204 hsa-miR-889 hsa-miR-29a hsa-miR-29c hsa-miR-548l hsa-miR-211 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: PPIC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIC (see all 7)
    OriGene shRNA RFP: PPIC
    OriGene siRNA: PPIC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPIC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIC (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIC 

    Cell Line
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    Search LifeMap BioReagents cell lines for PPIC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIC

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding ----
    GO:0016018cyclosporin A binding TAS1652374
    GO:0051082unfolded protein binding TAS1652374


    PPIC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ppictm1Jsf for PPIC
         1 MGI phenotypic allele for Ppic (no phenotypes)

    PPIC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPIC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PPIC (P458772, 3 ENSP000003030574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861888 I2D: score=3 STRING: ENSP00000357292
    LGALS3BPQ083803, ENSP000002627764I2D: score=1 STRING: ENSP00000262776
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ARSAENSP000002161244STRING: ENSP00000216124
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0007165signal transduction TAS1652374


    PPIC for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPIC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPIC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIC

    1 DrugBank Compound for PPIC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    6 Novoseek chemical compound relationships for PPIC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juglone 82.1 8 9558330 (3), 18539601 (1)
    tacrolimus 50.6 5 9558330 (1), 16610367 (1), 10966874 (1), 14977579 (1)
    fibrinogen 49 8 9282795 (3), 9701463 (1), 12643327 (1), 10695769 (1) (see all 5)
    cyclosporin a 48.1 13 8265636 (5), 8031755 (4), 9558330 (1), 7546642 (1)
    ptca 26 1 10440909 (1)
    warfarin 17.8 1 10695769 (1)

    Search CenterWatch for drugs/clinical trials and news about PPIC 

    Transcripts
    for PPIC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPIC gene: 
    NM_000943.4  

    Unigene Cluster for PPIC:

    Peptidylprolyl isomerase C (cyclophilin C)
    Hs.110364  [show with all ESTs]
    Unigene Representative Sequence: AK290321
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306442(uc003kth.3) ENST00000415659(uc011cwp.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PPIC
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIC
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIC:
    hsa-miR-204 hsa-miR-889 hsa-miR-29a hsa-miR-29c hsa-miR-548l hsa-miR-211 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: PPIC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIC (see all 7)
    OriGene shRNA RFP: PPIC
    OriGene siRNA: PPIC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIC
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPIC (NM_000943)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIC 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPIC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIC

    Additional cDNA sequence: 

    AK290321.1 AK304053.1 BC002678.2 L04460.1 S71018.1 

    5 DOTS entries:

    DT.100744754  DT.97807000  DT.99936478  DT.111742  DT.91712722 

    24/103 AceView cDNA sequences (see all 103):

    CA488493 BU857023 BX093499 NM_000943 BM833458 CR592786 BQ084414 BE613005 
    BM822723 T91633 BU580927 BE379145 AL711077 AA569906 BX472017 H88002 
    BF970748 AW103606 AI283010 BC002678 AI669559 BM974369 BU621286 BI962705 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPIC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                          -           -     -                     
    SP2:                          -     -           -                     
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for PPIC

    Expression
    for PPIC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCGTCCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPIC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Trophoblast-like cells (Generation of tropho...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPIC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIC

    SOURCE GeneReport for Unigene cluster: Hs.110364
        SABiosciences Custom PCR Arrays for PPIC
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIC

    Orthologs
    for PPIC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIC gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppic1 , 5 peptidylprolyl isomerase C1, 5 86.32(n)1
    90.57(a)1    		   18 (29.03 cM)5
    190381  NM_008908.41  NP_032934.11 
     534063415 
    chicken
    (Gallus gallus)    		 Aves PPIC1 peptidylprolyl isomerase C (cyclophilin C) 74.66(n)
    80.61(a)    		   768427  XM_001231332.2  XP_001231333.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PPIC6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343193.1(12288411-12296607)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.204492 Transcribed sequence with moderate similarity to protein more 79.58(n)    AL896133.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003331411 peptidyl-prolyl cis-trans isomerase C-like 68.91(n)
    71.5(a)    		   100333141  XM_002667830.2  XP_002667876.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG28523 peptidyl-prolyl cis-trans isomerase 66(a)
    (best of 2)    		   58F3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cyp-63 Expression: intestine, embryo, L1 larva, L2
    larva    		 67(a)
    (best of 2)    		   III(773386-774204)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CPR21 Cpr2p 58.9(n)
    60.12(a)    		   856454   NP_011924.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ROC41 Peptidyl-prolyl cis-trans isomerase CYP20-3 65.24(n)
    66.46(a)    		   825376  NM_001203230.1  NP_001190159.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 peptidyl-prolyl cis-trans isomerase, putative, exp...
    peptidyl-prolyl cis-trans isomerase, putative, exp...
    		 47(a)
    44(a)
    		 many ↔ many
    many ↔ many
    		 1(10192619-10195751)
    5(185622-188487)


    ENSEMBL Gene Tree for PPIC (if available)
    TreeFam Gene Tree for PPIC (if available) 

    Paralogs
    for PPIC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIC gene
    CWC272  PPIL42  PPWD12  PPIL32  PPIH2  PPIB2  PPIL12  PPIL22  
    18/22 SIMAP similar genes for PPIC using alignment to 1 protein entry:     PPIC_HUMAN(see all similar genes):
    PPIB    PPIE    PPIF    PPIA    PPIAL4A    PPIAL4B
    PPIAL4C    PPIAL4G    PPIL1    RANBP2    PPIH    LOC402252
    PPID    PPIG    PPIL6    NKTR    PPIL3    PPIL2

    PPIC for paralogs           About GeneDecksing



    Genomic Variants
    for PPIC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/247 NCBI SNPs in PPIC are shown (see all 247)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs21697731,2
    		C,F,A,--122358601(+) tcaagC/Aaatcc 1 -- ds50014Minor allele frequency- A:0.18NS NA CSA 160
    rs1391267591,2
    		--122358619(+) TCAGCC/GTCCTG 1 -- ds50010--------
    rs4015351,2
    		C,F,A,--122358685(+) gagacA/Ggggtc 1 -- ds50016Minor allele frequency- G:0.16NS NA CSA WA EA 518
    rs1848687931,2
    		--122358848(+) CCTATA/TGCAAC 1 -- ds50010--------
    rs100540271,2
    		C,A,--122358935(+) GGATGG/AGCATA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs354135551,2
    		C,F,--122359003(+) TCACTG/ATTAAT 1 -- ds50015Minor allele frequency- A:0.02NA NS 290
    rs767398891,2
    		C--122359010(+) TAATGA/CTAGAG 1 -- ds50010--------
    rs455619351,2
    		C,F,--122359085(-) ACTTTT/CAGATC 1 -- ut312Minor allele frequency- C:0.03NS WA 274
    rs155771,2
    		C,F,O,A,H,--122359190(+) TTTCTG/TTTTGG 1 -- ut3122Minor allele frequency- T:0.21MN NA NS EA CSA WA 2580
    rs455609341,2
    		C,F,--122359243(-) TGGGTA/GATGCT 1 -- ut312Minor allele frequency- G:0.03NS WA 288

    HapMap Linkage Disequilibrium report for PPIC (122358945 - 122372436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPIC: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PPIC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPIC for disorders           About GeneDecksing

    OMIM gene information: 123842    OMIM disorders: --

    11 diseases for PPIC:    About MalaCards
    disseminated intravascular coagulation    thrombotic thrombocytopenic purpura    myocardial infarction    acute myocardial infarction
    acute promyelocytic leukemia    purpura    diabetes mellitus    gastric cancer
    ataxia    leukemia    malaria

    1 Novoseek disease relationship for PPIC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    disseminated intravascular coagulation 72.7 1 10805276 (1)


    Export disorders for PPIC gene to outside databases

    Publications
    for PPIC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIC gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with PPIC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PubMed id 8031755)1, 2, 3, 9 Schneider H.... Movva N.R. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PubMed id 1383094)1, 3 Sugano S....Yamaguchi N. (1992)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1 Vasan R.S....Blankenberg S. (2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)

    External Searches for PPIC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPIC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5480 HGNC: 9256 AceView: PPIC Ensembl:ENSG00000168938 euGenes: HUgn5480
    ECgene: PPIC H-InvDB: PPIC

    Other Databases showing PPIC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPIC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIC Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppic/

    Intellectual Property
    for PPIC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPIC gene:
    Search GeneIP for patents involving PPIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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