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Aliases for PPIC Gene

Aliases for PPIC Gene

  • Peptidylprolyl Isomerase C (Cyclophilin C) 2 3
  • Cyclophilin C 3 4
  • Rotamase C 3 4
  • EC 4 63
  • PPIase C 3 4
  • CYPC 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase C 3
  • Parvulin 3

External Ids for PPIC Gene

Previous GeneCards Identifiers for PPIC Gene

  • GC05M121989
  • GC05M122686
  • GC05M122389
  • GC05M122435
  • GC05M122386
  • GC05M117547
  • GC05M122363

Summaries for PPIC Gene

Entrez Gene Summary for PPIC Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIC Gene

PPIC (Peptidylprolyl Isomerase C (Cyclophilin C)) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and cyclosporin A binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIC Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for PPIC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIC Gene

Genomics for PPIC Gene

Regulatory Elements for PPIC Gene

Genomic Location for PPIC Gene

123,023,250 bp from pter
123,036,741 bp from pter
13,492 bases
Minus strand

Genomic View for PPIC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIC Gene

Proteins for PPIC Gene

  • Protein details for PPIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase C
    Protein Accession:
    Secondary Accessions:
    • A4LBB5

    Protein attributes for PPIC Gene

    212 amino acids
    Molecular mass:
    22763 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PPIC Gene

neXtProt entry for PPIC Gene

Proteomics data for PPIC Gene at MOPED

Selected DME Specific Peptides for PPIC Gene

Post-translational modifications for PPIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PPIC Gene

Suggested Antigen Peptide Sequences for PPIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P45877
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIC: view

No data available for Gene Families for PPIC Gene

Function for PPIC Gene

Molecular function for PPIC Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Cyclosporin A (CsA) inhibits CYPC
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for PPIC Gene

Gene Ontology (GO) - Molecular Function for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0016018 cyclosporin A binding IDA 1652374
genes like me logo Genes that share ontologies with PPIC: view

miRNA for PPIC Gene

miRTarBase miRNAs that target PPIC

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIC Gene

Localization for PPIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIC Gene


Subcellular locations from

Jensen Localization Image for PPIC Gene COMPARTMENTS Subcellular localization image for PPIC gene
Compartment Confidence
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PPIC: view

Pathways for PPIC Gene

SuperPathways for PPIC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIC: view

No data available for Pathways by source for PPIC Gene

Compounds for PPIC Gene

(1) Drugbank Compounds for PPIC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target

(6) Novoseek inferred chemical compound relationships for PPIC Gene

Compound -log(P) Hits PubMed IDs
juglone 82.1 4
tacrolimus 50.6 4
fibrinogen 49 7
cyclosporin a 48.1 11
ptca 26 1
genes like me logo Genes that share compounds with PPIC: view

Transcripts for PPIC Gene

mRNA/cDNA for PPIC Gene

Unigene Clusters for PPIC Gene

Peptidylprolyl isomerase C (cyclophilin C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - -

Relevant External Links for PPIC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIC Gene

mRNA expression in normal human tissues for PPIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIC Gene

SOURCE GeneReport for Unigene cluster for PPIC Gene Hs.110364

genes like me logo Genes that share expressions with PPIC: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIC Gene

Orthologs for PPIC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIC 35
  • 99.06 (n)
  • 98.11 (a)
  • 98 (a)
(Bos Taurus)
Mammalia PPIC 35
  • 89.62 (n)
  • 92.92 (a)
  • 93 (a)
(Canis familiaris)
Mammalia PPIC 35
  • 84.69 (n)
  • 86.22 (a)
  • 85 (a)
(Mus musculus)
Mammalia Ppic 35
  • 86.32 (n)
  • 90.57 (a)
Ppic 16
Ppic 36
  • 91 (a)
(Monodelphis domestica)
Mammalia PPIC 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia PPIC 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Ppic 35
  • 84.75 (n)
  • 87.26 (a)
(Gallus gallus)
Aves PPIC 35
  • 74.83 (n)
  • 80.61 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia PPIC 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppic 35
  • 72.5 (n)
  • 77.5 (a)
Str.20449 35
(Danio rerio)
Actinopterygii LOC100333141 35
  • 68.54 (n)
  • 70.92 (a)
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2852 36
  • 62 (a)
ninaA 37
  • 51 (a)
CG2852 37
  • 66 (a)
(Caenorhabditis elegans)
Secernentea cyn-5 36
  • 62 (a)
cyn-6 36
  • 63 (a)
cyp-5 37
  • 66 (a)
cyp-6 37
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 35
  • 58.69 (n)
  • 60.12 (a)
CPR2 36
  • 50 (a)
CPR5 36
  • 44 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7094 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC4 35
  • 65.24 (n)
  • 66.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5529 36
  • 60 (a)
Species with no ortholog for PPIC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIC Gene

Gene Tree for PPIC (if available)
Gene Tree for PPIC (if available)

Paralogs for PPIC Gene

Paralogs for PPIC Gene

Selected SIMAP similar genes for PPIC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIC: view

Variants for PPIC Gene

Sequence variations from dbSNP and Humsavar for PPIC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15577 -- 123,023,495(+) TTTCT(G/T)TTTGG utr-variant-3-prime
rs401535 -- 123,022,990(+) GAGAC(A/G)GGGTC downstream-variant-500B
rs407392 -- 123,025,299(-) GGGAT(A/G)TTGTA intron-variant
rs451195 - 123,023,945(+) AGCAG(C/T)TGGTG reference, missense
rs1866107 -- 123,026,441(-) GTATA(C/T)ATTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIC Gene

Variant ID Type Subtype PubMed ID
nsv520349 CNV Loss 19592680

Relevant External Links for PPIC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIC Gene

Disorders for PPIC Gene

(1) Novoseek inferred disease relationships for PPIC Gene

Disease -log(P) Hits PubMed IDs
disseminated intravascular coagulation 72.7 1

Relevant External Links for PPIC

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PPIC: view

No data available for UniProtKB/Swiss-Prot for PPIC Gene

Publications for PPIC Gene

  1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PMID: 8031755) Schneider H. … Movva N.R. (Biochemistry 1994) 2 3 4 23
  2. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PMID: 1383094) Sugano S. … Yamaguchi N. (Gene 1992) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan R.S. … Blankenberg S. (JAMA 2009) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for PPIC Gene

  • Addgene plasmids for PPIC

Sources for PPIC Gene

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