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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIC Gene

protein-coding   GIFtS: 57
GCID: GC05M122363

Peptidylprolyl Isomerase C (Cyclophilin C)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase C (Cyclophilin C)1 2     PPIase C2 3
Cyclophilin C2 3     EC 5.2.1.83 8
Rotamase C2 3     parvulin2
CYPC2 3     Peptidyl-Prolyl Cis-Trans Isomerase C2

External Ids:    HGNC: 92561   Entrez Gene: 54802   Ensembl: ENSG000001689387   OMIM: 1238425   UniProtKB: P458773   

Export aliases for PPIC gene to outside databases

Previous GC identifers: GC05M121989 GC05M122686 GC05M122389 GC05M122435 GC05M122386 GC05M117547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIC Gene:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases
catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding
of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PPIC Gene: 
PPIC (peptidylprolyl isomerase C (cyclophilin C)) is a protein-coding gene. Diseases associated with PPIC include thrombotic thrombocytopenic purpura, and disseminated intravascular coagulation. GO annotations related to this gene include unfolded protein binding and cyclosporin A binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIC gene promoter:
         NF-YB   SRY   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIC promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

PPIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIC gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M122363:  view genomic region     (about GC identifiers)

Start:
122,358,945 bp from pter      End:
122,372,436 bp from pter
Size:
13,492 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase C  
Size: 212 amino acids; 22763 Da
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for PPIC:
2ESL (3D)    
Secondary accessions: A4LBB5

Explore the universe of human proteins at neXtProt for PPIC: NX_P45877

Explore proteomics data for PPIC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P45877

  • 4/7 DME Specific Peptides for PPIC (P45877) (see all 7)
     FMIQGGD  PKTVENF  KGSKFHR  TNGSQFF 

    PPIC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPIC Protein Expression
    REFSEQ proteins: NP_000934.1  
    ENSEMBL proteins: 
     ENSP00000303057  

    Human Recombinant Protein Products for PPIC: 
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    OriGene Protein Over-expression Lysate for PPIC
    OriGene MassSpec for PPIC 
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    Novus Biologicals PPIC Protein
    Novus Biologicals PPIC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPIC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PPIC for ontologies           About GeneDecksing



    PPIC Antibody Products: 
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    Cloud-Clone Corp. CLIAs for PPIC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P45877

    ProtoNet protein and cluster: P45877

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIC_HUMAN, P45877
    Similarity: Belongs to the cyclophilin-type PPIase family
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIC_HUMAN, P45877
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPC

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding ----
    GO:0016018cyclosporin A binding TAS1652374
    GO:0051082unfolded protein binding TAS1652374
         
    PPIC for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ppic (no phenotypes)

    PPIC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppictm1Jsf for PPIC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPIC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIC 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIC
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIC:
    hsa-miR-204 hsa-miR-889 hsa-miR-29a hsa-miR-29c hsa-miR-548l hsa-miR-211 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidPPIC 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PPIC (P458772, 3 ENSP000003030574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861888 I2D: score=3 STRING: ENSP00000357292
    LGALS3BPQ083803, ENSP000002627764I2D: score=1 STRING: ENSP00000262776
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ARSAENSP000002161244STRING: ENSP00000216124
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0007165signal transduction TAS1652374

    PPIC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPIC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIC

    1 DrugBank Compound for PPIC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3target--17139284 17016423

    6 Novoseek inferred chemical compound relationships for PPIC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juglone 82.1 8 9558330 (3), 18539601 (1)
    tacrolimus 50.6 5 9558330 (1), 16610367 (1), 10966874 (1), 14977579 (1)
    fibrinogen 49 8 9282795 (3), 9701463 (1), 12643327 (1), 10695769 (1) (see all 5)
    cyclosporin a 48.1 13 8265636 (5), 8031755 (4), 9558330 (1), 7546642 (1)
    ptca 26 1 10440909 (1)
    warfarin 17.8 1 10695769 (1)

    Search CenterWatch for drugs/clinical trials and news about PPIC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIC gene: 
    NM_000943.4  

    Unigene Cluster for PPIC:

    Peptidylprolyl isomerase C (cyclophilin C)
    Hs.110364  [show with all ESTs]
    Unigene Representative Sequence: AK290321
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306442(uc003kth.3) ENST00000415659(uc011cwp.1)
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIC:
    hsa-miR-204 hsa-miR-889 hsa-miR-29a hsa-miR-29c hsa-miR-548l hsa-miR-211 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidPPIC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIC
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIC
    Sirion Biotech Customized lentivirus for stable overexpression of PPIC 
                         Customized lentivirus expression plasmids for stable overexpression of PPIC 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIC
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    Additional mRNA sequence: 

    AK290321.1 AK304053.1 BC002678.2 L04460.1 S71018.1 

    5 DOTS entries:

    DT.100744754  DT.97807000  DT.99936478  DT.111742  DT.91712722 

    24/103 AceView cDNA sequences (see all 103):

    BX472017 AL711077 BM822723 BQ084414 BU580927 NM_000943 BE613005 BX093499 
    BU857023 H88002 AA569906 BM833458 BE379145 CA488493 CR592786 T91633 
    BM825588 BU617210 CA419624 CA425650 CA435319 BE741865 CA429548 BF691426 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPIC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                          -           -     -                     
    SP2:                          -     -           -                     
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for PPIC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIC expression in normal human tissues (normalized intensities)      PPIC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCGTCCACT
    PPIC Expression
    About this image


    PPIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             HSF-1 (UC01)
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See PPIC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIC

    SOURCE GeneReport for Unigene cluster: Hs.110364
        SABiosciences Custom PCR Arrays for PPIC
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIC gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppic1 , 5 peptidylprolyl isomerase C1, 5 86.32(n)1
    90.57(a)1
      18 (29.03 cM)5
    190381  NM_008908.41  NP_032934.11 
     534063415 
    chicken
    (Gallus gallus)
    Aves PPIC1 peptidylprolyl isomerase C (cyclophilin C) 74.66(n)
    80.61(a)
      768427  XM_001231332.2  XP_001231333.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPIC6
    Peptidyl-prolyl cis-trans isomerase
    76(a)
    1 ↔ 1
    GL343193.1(12285982-12297130)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204492 Transcribed sequence with moderate similarity to protein more 79.58(n)    AL896133.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003331411 peptidyl-prolyl cis-trans isomerase C-like 68.91(n)
    71.5(a)
      100333141  XM_002667830.2  XP_002667876.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28523 peptidyl-prolyl cis-trans isomerase 66(a)
    (best of 2)
      58F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-63 Expression: intestine, embryo, L1
    larva, L2 larva
    67(a)
    (best of 2)
      III(773386-774204)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR21 Cpr2p 58.9(n)
    60.12(a)
      856454   NP_011924.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ROC41 Peptidyl-prolyl cis-trans isomerase CYP20-3 65.24(n)
    66.46(a)
      825376  NM_001203230.1  NP_001190159.1 


    ENSEMBL Gene Tree for PPIC (if available)
    TreeFam Gene Tree for PPIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIC gene
    PPIH2  PPIB2  CWC272  PPWD12  PPIL42  PPIL22  PPIL32  PPIL12  
    18/22 SIMAP similar genes for PPIC using alignment to 1 protein entry:     PPIC_HUMAN(see all similar genes):
    PPIB    PPIA    PPIF    PPIE    PPIAL4A    PPIAL4B
    PPIAL4C    PPIAL4G    PPIL1    RANBP2    PPIAL4D    PPIH
    LOC402252    PPID    PPIG    PPIL6    NKTR    PPIL3

    PPIC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/320 SNPs in PPIC are shown (see all 320)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0607124
    ----see VAR_0607122 H L mis40--------
    rs21697731,2
    C,F,A--122358601(+) TCAAGC/AAATCC 1 -- ds50014Minor allele frequency- A:0.18NS NA CSA 160
    rs1391267591,2
    --122358619(+) TCAGCC/GTCCTG 1 -- ds50010--------
    rs4015351,2
    C,F,A--122358685(+) GAGACA/GGGGTC 1 -- ds50016Minor allele frequency- G:0.16NS NA CSA WA EA 518
    rs1848687931,2
    --122358848(+) CCTATA/TGCAAC 1 -- ds50010--------
    rs100540271,2
    C,F,A--122358935(+) GGATGG/AGCATA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs354135551,2
    C,F--122359003(+) TCACTG/ATTAAT 1 -- ds50015Minor allele frequency- A:0.02NA NS 290
    rs767398891,2
    C--122359010(+) TAATGA/CTAGAG 1 -- ds50010--------
    rs455619351,2
    C,F--122359085(-) ACTTTT/CAGATC 1 -- ut312Minor allele frequency- C:0.03NS WA 274
    rs155771,2
    C,F,O,A,H--122359190(+) TTTCTG/TTTTGG 1 -- ut3122Minor allele frequency- T:0.21MN NA NS EA CSA WA 2580

    HapMap Linkage Disequilibrium report for PPIC (122358945 - 122372436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPIC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520349CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123842    OMIM disorders: --

    9 diseases for PPIC:    About MalaCards
    thrombotic thrombocytopenic purpura    disseminated intravascular coagulation    acute promyelocytic leukemia    purpura
    acute myocardial infarction    myocardial infarction    diabetes mellitus    gastric cancer
    leukemia


    PPIC for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PPIC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    disseminated intravascular coagulation 72.7 1 10805276 (1)

    Genetic Association Database (GAD): PPIC

    Export disorders for PPIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIC gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with PPIC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PubMed id 8031755)1, 2, 3, 9 Schneider H.... Movva N.R. (1994)
    2. Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PubMed id 1383094)1, 3 Sugano S....Yamaguchi N. (1992)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5480 HGNC: 9256 AceView: PPIC Ensembl:ENSG00000168938 euGenes: HUgn5480
    ECgene: PPIC H-InvDB: PPIC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIC Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppic/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIC gene:
    Search GeneIP for patents involving PPIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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