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Aliases for PPIB Gene

Aliases for PPIB Gene

  • Peptidylprolyl Isomerase B (Cyclophilin B) 2 3
  • CYPB 3 4 6
  • S-Cyclophilin 3 4
  • Rotamase B 3 4
  • EC 4 63
  • PPIase B 3 4
  • CYP-S1 3 4
  • SCYLP 3 4
  • OI9 3 6
  • Peptidyl-Prolyl Cis-Trans Isomerase B 3
  • Epididymis Secretory Protein Li 39 3
  • Cyclophilin-Like Protein 3
  • Cyclophilin B 4
  • HEL-S-39 3

External Ids for PPIB Gene

Previous GeneCards Identifiers for PPIB Gene

  • GC15M060234
  • GC15M057607
  • GC15M062026
  • GC15M062163
  • GC15M062235
  • GC15M064448
  • GC15M041272

Summaries for PPIB Gene

Entrez Gene Summary for PPIB Gene

  • The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

GeneCards Summary for PPIB Gene

PPIB (Peptidylprolyl Isomerase B (Cyclophilin B)) is a Protein Coding gene. Diseases associated with PPIB include osteogenesis imperfecta, type ix and ppib-related osteogenesis imperfecta. Among its related pathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIL1.

UniProtKB/Swiss-Prot for PPIB Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for PPIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIB Gene

Genomics for PPIB Gene

Regulatory Elements for PPIB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIB Gene

64,155,812 bp from pter
64,163,205 bp from pter
7,394 bases
Minus strand

Genomic View for PPIB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIB Gene

Proteins for PPIB Gene

  • Protein details for PPIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase B
    Protein Accession:
    Secondary Accessions:
    • A8K534
    • Q6IBH5
    • Q9BVK5

    Protein attributes for PPIB Gene

    216 amino acids
    Molecular mass:
    23743 Da
    Quaternary structure:
    • Interacts with DYM. Interacts with CALR, CLGN and CANX.
    • Sequence=AAA52150.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPIB Gene

neXtProt entry for PPIB Gene

Proteomics data for PPIB Gene at MOPED

Selected DME Specific Peptides for PPIB Gene

Post-translational modifications for PPIB Gene

  • Ubiquitination at Lys67, Lys98, Lys131, Lys158, Lys165, and Lys209
  • Glycosylation at Asn148
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for PPIB Gene

Gene Families for PPIB Gene

Suggested Antigen Peptide Sequences for PPIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
genes like me logo Genes that share domains with PPIB: view

Function for PPIB Gene

Molecular function for PPIB Gene

GENATLAS Biochemistry:
peptidyl-propyl isomerase B
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation:
Cyclosporin A (CsA) inhibits CYPB
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for PPIB Gene

Gene Ontology (GO) - Molecular Function for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity NAS 2000394
GO:0005515 protein binding IPI 15095401
GO:0005518 contributes_to collagen binding ISS --
GO:0032403 protein complex binding ISS --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with PPIB: view
genes like me logo Genes that share phenotypes with PPIB: view

Animal Models for PPIB Gene

MGI Knock Outs for PPIB:

Animal Model Products

miRNA for PPIB Gene

miRTarBase miRNAs that target PPIB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIB

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PPIB Gene

Localization for PPIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIB Gene

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for PPIB Gene COMPARTMENTS Subcellular localization image for PPIB gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005783 endoplasmic reticulum IDA 20089953
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PPIB: view

Pathways for PPIB Gene

genes like me logo Genes that share pathways with PPIB: view

Pathways by source for PPIB Gene

Gene Ontology (GO) - Biological Process for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization ISS --
GO:0006457 protein folding --
GO:0030198 extracellular matrix organization TAS --
GO:0040018 positive regulation of multicellular organism growth IMP 20089953
GO:0044794 positive regulation by host of viral process IMP 15989969
genes like me logo Genes that share ontologies with PPIB: view

Drugs for PPIB Gene

(2) Drugbank Compounds for PPIB Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (-)-(S)-Proline
147-85-3 145742 Target binder approved, nutraceutical
446094 Target experimental

(1) ApexBio Compounds for PPIB Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent [59865-13-3]

(1) HMDB Compounds for PPIB Gene

Compound Synonyms Cas Number PubMed IDs
  • (-)-(S)-Proline

(5) Novoseek inferred chemical compound relationships for PPIB Gene

Compound -log(P) Hits PubMed IDs
cyclosporin a 69.9 29
heparan sulfate 56.2 12
proline 38.6 3
anti-fungal 24.4 3
heparin 22.8 5
genes like me logo Genes that share compounds with PPIB: view

Transcripts for PPIB Gene

mRNA/cDNA for PPIB Gene

Unigene Clusters for PPIB Gene

Peptidylprolyl isomerase B (cyclophilin B):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for PPIB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIB Gene

mRNA expression in normal human tissues for PPIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIB Gene

SOURCE GeneReport for Unigene cluster for PPIB Gene Hs.434937

genes like me logo Genes that share expressions with PPIB: view

Expression partners for PPIB Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIB Gene

Orthologs for PPIB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPIB 35
  • 90.22 (n)
  • 93.75 (a)
  • 94 (a)
(Canis familiaris)
Mammalia PPIB 35
  • 90.59 (n)
  • 95.83 (a)
  • 96 (a)
(Mus musculus)
Mammalia Ppib 35
  • 90.12 (n)
  • 93.98 (a)
Ppib 16
Ppib 36
  • 94 (a)
(Pan troglodytes)
Mammalia PPIB 35
  • 99.85 (n)
  • 99.54 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppib 35
  • 89.1 (n)
  • 93.27 (a)
(Monodelphis domestica)
Mammalia PPIB 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PPIB 36
  • 89 (a)
(Gallus gallus)
Aves PPIB 35
  • 80.84 (n)
  • 86.47 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia PPIB 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppib 35
  • 76.76 (n)
  • 87.5 (a)
Str.806 35
African clawed frog
(Xenopus laevis)
Amphibia ppib-prov 35
(Danio rerio)
Actinopterygii ppib 35
  • 76.08 (n)
  • 81.02 (a)
wufa97f08 35
ppib 36
  • 82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8306 35
fruit fly
(Drosophila melanogaster)
Insecta CG2852 37
  • 73 (a)
ninaA 37
  • 52 (a)
CG2852 35
  • 68.17 (n)
  • 67.5 (a)
CG2852 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007088 35
  • 65.62 (n)
  • 70.68 (a)
(Caenorhabditis elegans)
Secernentea cyp-3 37
  • 62 (a)
cyp-5 37
  • 71 (a)
cyp-6 37
  • 69 (a)
cyp-8 37
  • 52 (a)
cyn-5 35
  • 63.35 (n)
  • 67.66 (a)
cyn-5 36
  • 66 (a)
cyn-6 36
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL056C 35
  • 58.28 (n)
  • 60.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10208g 35
  • 58.09 (n)
  • 60.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR5 35
  • 55.56 (n)
  • 56.08 (a)
CPR2 36
  • 50 (a)
CPR5 36
  • 47 (a)
CPR5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP20-2 35
  • 62.13 (n)
  • 65.09 (a)
(Oryza sativa)
Liliopsida Os05g0103200 35
  • 63.04 (n)
  • 63.21 (a)
(Triticum aestivum)
Liliopsida Ta.28895 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01200 35
  • 65.46 (n)
  • 67.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp4 35
  • 61.29 (n)
  • 67.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5529 36
  • 71 (a)
Species with no ortholog for PPIB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIB Gene

Gene Tree for PPIB (if available)
Gene Tree for PPIB (if available)

Paralogs for PPIB Gene

Paralogs for PPIB Gene

(23) SIMAP similar genes for PPIB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIB: view

Variants for PPIB Gene

Sequence variations from dbSNP and Humsavar for PPIB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4904 untested 64,162,924(-) GGGTC(A/C)GTCTT synonymous-codon, reference
rs2307247 untested 64,160,123(-) TTCAC(C/T)AGGGG reference, synonymous-codon
rs3848146 -- 64,163,961(-) GTAGA(G/T)TGGGA upstream-variant-2KB
rs7182032 -- 64,164,156(+) GTAGT(C/G)TTCAT upstream-variant-2KB
rs7182202 -- 64,164,236(+) TTACA(C/T)AGGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPIB Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
nsv827360 CNV Loss 20364138

Relevant External Links for PPIB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIB Gene

Disorders for PPIB Gene

(1) OMIM Diseases for PPIB Gene (123841)


  • Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. {ECO:0000269 PubMed:19781681, ECO:0000269 PubMed:20089953}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PPIB Gene

Relevant External Links for PPIB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PPIB: view

No data available for Novoseek inferred disease relationships and Genatlas for PPIB Gene

Publications for PPIB Gene

  1. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PMID: 2000394) Price E.R. … Walsh C.T. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PMID: 20089953) Barnes A.M. … Marini J.C. (N. Engl. J. Med. 2010) 2 3 4 23
  3. A novel secreted cyclophilin-like protein (SCYLP). (PMID: 2040592) Spik G. … Movva N.R. (J. Biol. Chem. 1991) 3 4 23
  4. PPIB mutations cause severe osteogenesis imperfecta. (PMID: 19781681) van Dijk F.S. … Pals G. (Am. J. Hum. Genet. 2009) 3 4 23
  5. Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer. (PMID: 19056847) Fang F. … Clevenger C.V. (Am. J. Pathol. 2009) 3 23

Products for PPIB Gene

  • Addgene plasmids for PPIB

Sources for PPIB Gene

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