Aliases for PPIB Gene
Aliases for PPIB Gene
External Ids for PPIB Gene
- HGNC: 9255
- Entrez Gene: 5479
- Ensembl: ENSG00000166794
- OMIM: 123841
- UniProtKB: P23284
Previous GeneCards Identifiers for PPIB Gene
- GC15M060234
- GC15M057607
- GC15M062026
- GC15M062163
- GC15M062235
- GC15M064448
- GC15M041272
Summaries for PPIB Gene
-
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
GeneCards Summary for PPIB Gene
PPIB (Peptidylprolyl Isomerase B) is a Protein Coding gene. Diseases associated with PPIB include Osteogenesis Imperfecta, Type Ix and Osteogenesis Imperfecta, Type Ii. Among its related pathways are Collagen chain trimerization and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is PPIC.
UniProtKB/Swiss-Prot for PPIB Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Additional gene information for PPIB Gene
- Monarch Initiative
- Search for PPIB at DataMed
- Search for PPIB at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIB Gene
Genomics for PPIB Gene
GeneHancer (GH) Regulatory Elements for PPIB Gene
Promoters and enhancers for PPIB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PPIB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PPIB Gene
Genomic Locations for PPIB Gene
- chr15:64,155,812-64,163,205
- (GRCh38/hg38)
- Size:
- 7,394 bases
- Orientation:
- Minus strand
- chr15:64,448,011-64,455,404
- (GRCh37/hg19)
Genomic View for PPIB Gene
Genes around PPIB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by Ensembl
- 15q22.31 by Entrez Gene
- 15q22.31 by HGNC
PPIB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPIB Gene
Proteins for PPIB Gene
-
Protein details for PPIB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23284-PPIB_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase B
- Protein Accession:
- P23284
- A8K534
- Q6IBH5
- Q9BVK5
Protein attributes for PPIB Gene
- Size:
- 216 amino acids
- Molecular mass:
- 23743 Da
- Quaternary structure:
-
- Interacts with DYM. Interacts with CALR, CLGN and CANX.
- SequenceCaution:
-
- Sequence=AAA52150.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PPIB Gene
Selected DME Specific Peptides for PPIB Gene
- P23284:
-
- FMIQGGD
- QGGDFTRG
- NGSQFFITTV
- TNGSQFF
- ALATGEKG
- TGEKGFGY
- DENFKLKH
- GKTVPKT
- GGKSIYG
- LDGKHVVFG
Post-translational modifications for PPIB Gene
Other Protein References for PPIB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PPIB (Cyclophilin B)
- Cell Signaling Technology (CST) Antibodies for PPIB (PPIB)
-
Custom Antibody ServicesOriGene Antibodies for PPIB
- Novus Biologicals Antibodies for PPIB
-
Abcam antibodies for PPIB
-
Cloud-Clone Corp. Antibodies for PPIB
- Invitrogen Antibodies for PPIB
- GeneTex PPIB antibody for PPIB
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPIB
- Sino Biological Antibodies for PPIB
Protein Products
-
OriGene Purified Proteins for PPIB
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIB
- Origene Custom Protein Services for PPIB
- Sino Biological Cell Lysates for PPIB
- Sino Biological Recombinant Proteins for PPIB
- ProSpec Recombinant Proteins for PPIB
-
Cloud-Clone Corp. Proteins for PPIB
- Search GeneTex for Proteins for PPIB
-
ProSci Proteins for PPIB
-
Abcam proteins for PPIB
Assay Products
-
Cloud-Clone Corp. Assay Kits for PPIB
Domains & Families for PPIB Gene
Gene Families for PPIB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
Protein Domains for PPIB Gene
Suggested Antigen Peptide Sequences for PPIB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P23284UniProtKB/Swiss-Prot:
PPIB_HUMAN :- Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
- Family:
-
- Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Function for PPIB Gene
Molecular function for PPIB Gene
- GENATLAS Biochemistry:
- peptidyl-propyl isomerase B
- UniProtKB/Swiss-Prot CatalyticActivity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Cyclosporin A (CsA) inhibits CYPB.
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Enzyme Numbers (IUBMB) for PPIB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA,IDA | 22658674 |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IBA,NAS | 2000394 |
| GO:0005515 | protein binding | IPI | 15095401 |
| GO:0005518 | contributes_to collagen binding | ISS | -- |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for PPIB Gene
- MGI mutant phenotypes for PPIB:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PPIB:
Animal Models for PPIB Gene
- MGI Knock Outs for PPIB:
-
- Ppib tm1.1Rjb
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PPIB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIB gene
- Search ViGene Biosciences for PPIB
CRISPR Products
-
OriGene CRISPR knockouts for PPIB
- genomics-online: gRNA clones - Search results for available PPIB gene related products
- Applied Biological Materials CRISPR for PPIB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIB
- GenScript: Design CRISPR guide RNA sequences for PPIB
miRNA for PPIB Gene
- miRTarBase miRNAs that target PPIB
-
- hsa-mir-1-3p (MIRT001347)
- hsa-mir-301a-3p (MIRT044215)
- hsa-mir-92a-3p (MIRT049173)
- hsa-mir-3972 (MIRT513158)
- hsa-mir-1202 (MIRT513159)
- hsa-mir-3194-5p (MIRT513160)
- hsa-mir-572 (MIRT513161)
- hsa-mir-6784-5p (MIRT513162)
- hsa-mir-3065-3p (MIRT513163)
- hsa-mir-181d-3p (MIRT513164)
- hsa-mir-4655-5p (MIRT513165)
- hsa-mir-520d-5p (MIRT733731)
- hsa-mir-1294 (MIRT737181)
- hsa-mir-1914-3p (MIRT738517)
- hsa-mir-206 (MIRT738850)
- hsa-mir-2861 (MIRT739504)
- hsa-mir-3184-5p (MIRT740874)
- hsa-mir-3190-3p (MIRT740963)
- hsa-mir-423-5p (MIRT743271)
- hsa-mir-4316 (MIRT744005)
- hsa-mir-4481 (MIRT745117)
- hsa-mir-455-3p (MIRT746207)
- hsa-mir-4745-5p (MIRT748188)
- hsa-mir-5194 (MIRT749981)
- hsa-mir-613 (MIRT752477)
- hsa-mir-6734-5p (MIRT754147)
- hsa-mir-6735-3p (MIRT754160)
- hsa-mir-6738-5p (MIRT754276)
- hsa-mir-6811-3p (MIRT756677)
- hsa-mir-6833-5p (MIRT757155)
- hsa-mir-7114-5p (MIRT759147)
- hsa-mir-8066 (MIRT760070)
miRNA Products
- Search ViGene Biosciences for PPIB
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for PPIB
- Browse OriGene Inhibitory RNA Products For PPIB
- genomics-online: shRNA clones - Search results for available PPIB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIB gene
Clone Products
- Sino Biological Human cDNA Clone for PPIB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PPIB
- genomics-online: cdna clones - Search results for available PPIB gene related products
- orf clones - Search results for available PPIB gene related products
- Applied Biological Materials Clones for PPIB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PPIB
-
ViGene Biosciences adenoviral particle packaged cDNA for PPIB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPIB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIB gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PPIB Gene
Localization for PPIB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPIB Gene
- Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269 PubMed:17081065}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
- Endoplasmic reticulum (3)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005783 | endoplasmic reticulum | IDA,TAS | 20089953 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005790 | smooth endoplasmic reticulum | IEA | -- |
| GO:0005925 | focal adhesion | IDA,HDA | 21423176 |
Pathways & Interactions for PPIB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization | ||
| 2 | Degradation of the extracellular matrix | ||
| 3 | RANK Signaling in Osteoclasts | ||
| 4 | Prolactin Signaling Pathway | ||
| 5 | Syndecan-1-mediated signaling events | ||
Pathways by source for PPIB Gene
2 BioSystems pathways for PPIB Gene
3 Reactome pathways for PPIB Gene
1 GeneGo (Thomson Reuters) pathway for PPIB Gene
Interacting Proteins for PPIB Gene
Selected Interacting proteins:
ENSP00000300026
P23284-PPIB_HUMAN
for PPIB Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | ISS | -- |
| GO:0006457 | protein folding | IEA | -- |
| GO:0040018 | positive regulation of multicellular organism growth | IMP | 20089953 |
| GO:0044794 | positive regulation by host of viral process | IMP | 15989969 |
| GO:0044829 | positive regulation by host of viral genome replication | IMP | 15989969 |
No data available for SIGNOR curated interactions for PPIB Gene
Drugs & Compounds for PPIB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| L-Proline | Approved | Nutra | Target, binder | 0 | ||
| Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist | Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor | 0 | |
| 1,4-Dithiothreitol | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for PPIB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cyclosporin A | Immunosuppressive agent | 59865-13-3 |
Transcripts for PPIB Gene
mRNA/cDNA for PPIB Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (953) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPIB Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPIB
- genomics-online: gRNA clones - Search results for available PPIB gene related products
- Applied Biological Materials CRISPR for PPIB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIB
- GenScript: Design CRISPR guide RNA sequences for PPIB
miRNA Products
- Search ViGene Biosciences for PPIB
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for PPIB
- Browse OriGene Inhibitory RNA Products For PPIB
- genomics-online: shRNA clones - Search results for available PPIB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIB gene
Clone Products
- Sino Biological Human cDNA Clone for PPIB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PPIB
- genomics-online: cdna clones - Search results for available PPIB gene related products
- orf clones - Search results for available PPIB gene related products
- Applied Biological Materials Clones for PPIB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: |
Expression for PPIB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PPIB Gene:
PPIBSOURCE GeneReport for Unigene cluster for PPIB Gene:
Hs.434937Evidence on tissue expression from TISSUES for PPIB Gene
- Skin(4.8)
- Nervous system(4.7)
- Liver(4.6)
- Lung(3.7)
- Stomach(3.6)
- Pancreas(3.3)
- Intestine(3)
- Kidney(2.7)
- Thyroid gland(2.5)
- Blood(2.4)
- Eye(2.3)
- Gall bladder(2.3)
- Spleen(2.3)
- Adrenal gland(2.2)
- Bone marrow(2.2)
- Lymph node(2.2)
- Heart(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIB Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cheek
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- middle ear
- mouth
- neck
- nose
- skull
- tongue
- tooth
- vocal cord
Thorax:
- chest wall
- clavicle
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- biliary tract
- intestine
- kidney
- liver
- stomach
Pelvis:
- pelvis
- ureter
- uterus
- vagina
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for PPIB
-
OriGene qPCR primer pairs and template standards for PPIB
- genomics-online: primer clones - Search results for available PPIB gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIB Gene
Orthologs for PPIB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPIB 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PPIB 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PPIB 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppib 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ppib 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPIB 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PPIB 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PPIB 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PPIB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppib 33 |
|
||
| Str.806 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ppib-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppib 33 34 |
|
||
| wufa97f08 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8306 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG2852 35 33 34 |
|
||
| ninaA 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007088 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cyp-5 35 |
|
|
|
| cyp-6 35 |
|
|
|||
| cyn-6 34 |
|
ManyToMany | |||
| cyn-5 33 34 |
|
||||
| cyp-3 35 |
|
|
|||
| cyp-8 35 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL056C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C10208g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CPR5 33 34 36 |
|
||
| CPR2 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CYP20-2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0103200 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.28895 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5529 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01200 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cyp4 33 |
|
- Species where no ortholog for PPIB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PPIB Gene
(23) SIMAP similar genes for PPIB Gene using alignment to 1 proteins:
Variants for PPIB Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112481305 | likely-benign, Osteogenesis Imperfecta, Recessive | 64,163,157(-) | G/A | upstream_transcript_variant | |
| rs113066141 | likely-benign, Osteogenesis Imperfecta, Recessive | 64,163,167(-) | C/T | upstream_transcript_variant | |
| rs113626158 | uncertain-significance, Osteogenesis Imperfecta, Recessive | 64,155,833(-) | A/C/T | 3_prime_UTR_variant | |
| rs121434559 | pathogenic, not-provided, Osteogenesis imperfecta type 9, not provided | 64,156,802(-) | G/A | coding_sequence_variant, stop_gained | |
| rs137853864 | pathogenic, not-provided, Osteogenesis imperfecta type 9, not provided, Osteogenesis imperfecta 9 (OI9) [MIM:259440] | 64,162,961(-) | A/C/G/T | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPIB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIB Gene
Disorders for PPIB Gene
(9) MalaCards diseases for PPIB Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| osteogenesis imperfecta, type ix |
|
|
| osteogenesis imperfecta, type ii |
|
|
| osteogenesis imperfecta, type iv |
|
|
| osteogenesis imperfecta, type iii |
|
|
| syphilis |
|
|
Search PPIB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PPIB_HUMAN- Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. {ECO:0000269 PubMed:19781681, ECO:0000269 PubMed:20089953}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PPIB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PPIB Gene
Publications for PPIB Gene
- Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PMID: 20089953) Barnes AM … Marini JC (The New England journal of medicine 2010) 2 3 4 22 58
- Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. (PMID: 2000394) Price ER … Walsh CT (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22 58
- PPIB mutations cause severe osteogenesis imperfecta. (PMID: 19781681) van Dijk FS … Pals G (American journal of human genetics 2009) 3 4 22 58
- A novel secreted cyclophilin-like protein (SCYLP). (PMID: 2040592) Spik G … Kocher HP (The Journal of biological chemistry 1991) 3 4 22 58
- Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and golgi organization and is associated with protein secretion pathways critical in bone development. (PMID: 21280149) Denais C … Machado RD (Human mutation 2011) 3 4 58
Products for PPIB Gene
- R&D Systems Antibodies for PPIB (Cyclophilin B)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PPIB
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PPIB
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIB
- Origene Custom Protein Services for PPIB
- Origene shrna and RNAi products in human, mouse, rat for PPIB
- Browse OriGene Inhibitory RNA Products For PPIB
- OriGene qPCR primer pairs and template standards for PPIB
- OriGene qPCR primer pairs for PPIB
- OriGene CRISPR knockouts for PPIB
- OriGene ORF clones in human for PPIB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPIB
- GenScript: Next-day shipping of latest version cDNA ORF clones for PPIB in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PPIB
- GenScript Custom Assay Services for PPIB
- GenScript Custom overexpressing Cell Line Services for PPIB
- GenScript: Design CRISPR guide RNA sequences for PPIB
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PPIB
- Cell Signaling Technology (CST) Antibodies for PPIB (PPIB)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PPIB
- Sino Biological Cell Lysates for PPIB
- Sino Biological Recombinant Proteins for PPIB
- Sino Biological Antibodies for PPIB
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PPIB
- Novus Biologicals lysates and proteins for PPIB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PPIB
- Abcam proteins for PPIB
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PPIB
- Cloud-Clone Corp. Antibodies for PPIB
- Cloud-Clone Corp. Proteins for PPIB
- Cloud-Clone Corp. Assay Kits for PPIB
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PPIB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for PPIB
- Addgene plasmids for PPIB
- antibodies-online: Search results for 123 available PPIB Antibodies ranked by validation data
- Compare Top PPIB Antibodies
- antibodies-online: Search results for 51 available PPIB Elisa Kits ranked by validation data
- Compare Top PPIB Elisa Kits
- antibodies-online: Search results for 30 available PPIB Proteins ranked by validation data
- Compare Top PPIB Proteins
- GeneTex PPIB antibody for PPIB
- Search GeneTex for Proteins for PPIB
- ViGene Biosciences adenoviral particle packaged cDNA for PPIB gene
- ViGene Biosciences lentiviral particle packaged cDNA for PPIB gene
- ViGene Biosciences ready-to-package AAV shRNAs for PPIB gene
- Search ViGene Biosciences for PPIB
- Santa Cruz Biotechnology (SCBT) Antibodies for PPIB
- Search Santa Cruz Biotechnology (SCBT) for PPIB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPIB
- Search for PPIB Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PPIB
- Horizon Cell Lines for PPIB
- genomics-online: cdna clones - Search results for available PPIB gene related products
- orf clones - Search results for available PPIB gene related products
- genomics-online: gRNA clones - Search results for available PPIB gene related products
- genomics-online: primer clones - Search results for available PPIB gene related products
- genomics-online: shRNA clones - Search results for available PPIB gene related products
Sources for PPIB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew