Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPIB Gene

protein-coding GIFtS: 75
GCID: GC15M064448

Peptidylprolyl Isomerase B (Cyclophilin B)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase B (Cyclophilin B)¹ ²		PPIase B² ³
CYPB² ³ ⁵		EC 5.2.1.8³ ⁸
Rotamase B² ³		OI9² ⁵
CYP-S1² ³		Cyclophilin-Like Protein²
S-cyclophilin² ³		Peptidyl-Prolyl Cis-Trans Isomerase B²
SCYLP² ³		Cyclophilin B³

External Ids:	HGNC: 9255¹	Entrez Gene: 5479²	Ensembl: ENSG00000166794⁷	OMIM: 123841⁵	UniProtKB: P23284³

Export aliases for PPIB gene to outside databases

Previous GC identifers: GC15M060234 GC15M057607 GC15M062026 GC15M062163 GC15M062235 GC15M041272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIB Gene:

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic

reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind

to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants

have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. (provided by

RefSeq, Oct 2009)

GeneCards Summary for PPIB Gene:

PPIB (peptidylprolyl isomerase B (cyclophilin B)) is a protein-coding gene. Diseases associated with PPIB include ppib-related osteogenesis imperfecta, and osteogenesis imperfecta type 9, and among its related super-pathways are Collagen formation and BAFF in B-Cell Signaling. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides

Gene Wiki entry for PPIB Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.2 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPIB gene promoter:
Bach1 AP-1 Tal-1 E47 AREB6 FAC1 Pax-3 Hand1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPIB promoter sequence

Search SABiosciences Chromatin IP Primers for PPIB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q21-q22

PPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIB gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M064448: view genomic region (about GC identifiers)

Start:	64,448,011 bp from pter	End:	64,455,404 bp from pter
Size:	7,394 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase B precursor

Size: 216 amino acids; 23743 Da

Subunit: Interacts with DYM

Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

Caution: It is uncertain whether Met-1 or Met-9 is the initiator

Sequence caution: Sequence=AAA52150.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for PPIB:

1CYN (3D)

3ICH (3D)

3ICI (3D)

Secondary accessions: A8K534 Q6IBH5 Q9BVK5

Explore the universe of human proteins at neXtProt for PPIB: NX_P23284

Explore proteomics data for PPIB at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P23284

4/10 DME Specific Peptides for PPIB (P23284) (see all 10)

GGKSIYG

FMIQGGD

GKTVPKT

TNGSQFF

PPIB Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_000933.1

ENSEMBL proteins:

ENSP00000300026

Reactome Protein details: P23284
Human Recombinant Protein Products for PPIB:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for PPIB OriGene Protein Over-expression Lysate for PPIB OriGene MassSpec for PPIB OriGene Custom Protein Services for PPIB
	GenScript Custom Purified and Recombinant Proteins Services for PPIB
	Novus Biologicals PPIB Proteins Novus Biologicals PPIB Lysate
	Sino Biological Recombinant Protein for PPIB Sino Biological Cell Lysate for PPIB
	ProSpec Recombinant Protein for PPIB
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	2000394
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0042470	melanosome	IEA	--

PPIB for ontologies About GeneDecksing

PPIB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PPIB (Cyclophilin B)
	Browse OriGene Antibodies OriGene Custom Antibody Services for PPIB
	GenScript Custom Superior Antibodies Services for PPIB
	Novus Biologicals PPIB Antibodies
	Abcam antibodies for PPIB
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for PPIB
	LSBio Antibodies in human, mouse, rat for PPIB

Assay Products for PPIB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PPIB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PPIB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR002130 Cyclophilin-like_PPIase_dom

IPR024936 Cyclophilin-type_PPIase

IPR020892 Cyclophilin-type_PPIase_CS

Graphical View of Domain Structure for InterPro Entry P23284

ProtoNet protein and cluster: P23284

1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Similarity: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily

Similarity: Contains 1 PPIase cyclophilin-type domain

PPIB for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PPIB_HUMAN, P23284

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB

Genatlas biochemistry entry for PPIB:

peptidyl-propyl isomerase B

Enzyme Number (IUBMB): EC 5.2.1.8¹ ²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	NAS	2000394
GO:0005515	protein binding	IPI	15095401
GO:0042277	peptide binding	IEA	--
GO:0051082	unfolded protein binding	TAS	2000394

PPIB for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for PPIB:

Increased G1 DNA content

Increased HPV18 LCR reporter a

Wnt reporter downregulated

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppib):

growth/size

integument

mortality/aging

no phenotypic analysis

skeleton

PPIB for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Ppib^tm1.1Rjb for PPIB

inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIB

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPIB

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIB

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIB

miRNA Products:		miRTarBase miRNAs that target PPIB: hsa-mir-1 (MIRT001347)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
		hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
		SwitchGear 3'UTR luciferase reporter plasmid: PPIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PPIB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PPIB
			Sirion Biotech Customized adenovirus for overexpression of PPIB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for PPIB (see all 7) OriGene ORF clones in mouse, rat for PPIB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
		Sino Biological Human cDNA Clone for PPIB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
		Sirion Biotech Customized lentivirus for stable overexpression of PPIB Customized lentivirus expression plasmids for stable overexpression of PPIB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPIB
		Search LifeMap BioReagents cell lines for PPIB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PPIB About

See pathways by source

SuperPath

Contained pathways About

Collagen biosynthesis and modifying enzymes

	Collagen biosynthesis and modifying enzymes	0.74			Extracellular matrix organization	0.39
	Collagen formation	0.74

BAFF in B-Cell Signaling

Apoptosis and survival APRIL and BAFF signaling

0.39

Development Prolactin receptor signaling

Prolactin Signaling Pathway

0.39

Syndecan-1-mediated signaling events

Syndecan-1-mediated signaling events

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for PPIB

Apoptosis and survival APRIL and BAFF signaling

1 GeneGo (Thomson Reuters) Pathway for PPIB

Apoptosis and survival APRIL and BAFF signaling

2 BioSystems Pathways for PPIB

	Prolactin Signaling Pathway
	Syndecan-1-mediated signaling events

3 Reactome Pathways for PPIB

	Extracellular matrix organization
	Collagen biosynthesis and modifying enzymes
	Collagen formation

PPIB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPIB

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/60 Interacting proteins for PPIB (P23284^{2, 3} ENSP00000300026⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 60)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF1	Q13077²^,³	MINT-49520 I2D: score=2
ENSG00000206353	Q15477³	I2D: score=1
ENSG00000223493	Q15477³	I2D: score=1
ENSG00000225737	Q15477³	I2D: score=1
ENSG00000228896	Q15477³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000413	protein peptidyl-prolyl isomerization	NAS	2000394
GO:0006457	protein folding	IEA	--
GO:0030198	extracellular matrix organization	TAS	--

PPIB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPIB for compounds About GeneDecksing

EMD Millipore small molecules for PPIB:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPIB

1 HMDB Compound for PPIB About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Proline	(-)-(S)-Proline (see all 16)	147-85-3	--

2 DrugBank Compounds for PPIB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Proline	(-)-2-Pyrrolidinecarboxylic acid (see all 6)	147-85-3	target	binder	17139284 11752352 17016423
1,4-Dithiothreitol	--	--	target	--	10592235

5 Novoseek inferred chemical compound relationships for PPIB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclosporin a	69.9	42	9378502 (4), 10386979 (4), 8713086 (3), 11955071 (2) (see all 19)
heparan sulfate	56.2	21	19940140 (4), 17588944 (4), 15109301 (4)
proline	38.6	5	19781681 (2), 17630507 (1)
anti-fungal	24.4	3	15245883 (1), 11848297 (1), 11732686 (1)
heparin	22.8	6	15109301 (4), 19940140 (1)

Search CenterWatch for drugs/clinical trials and news about PPIB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPIB gene:

NM_000942.4

Unigene Cluster for PPIB:

Peptidylprolyl isomerase B (cyclophilin B)

Hs.434937 [show with all ESTs]

Unigene Representative Sequence: BQ049986

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300026(uc002and.3) ENST00000558492 ENST00000561048(uc010bgx.1)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
		hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
		SwitchGear 3'UTR luciferase reporter plasmid: PPIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PPIB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB

Clone Products:		OriGene clones in human, mouse for PPIB (see all 7) OriGene ORF clones in mouse, rat for PPIB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
		Sirion Biotech Customized lentivirus for stable overexpression of PPIB Customized lentivirus expression plasmids for stable overexpression of PPIB

Primer Products:		OriGene qPCR primer pairs and template standards for PPIB OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PPIB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB

Additional mRNA sequence:

AK291149.1 AK311074.1 BC001125.2 BC008848.2 BC020800.1 BC032138.2 CR456829.1 M60457.1

M60857.1 M63573.1

24/27 DOTS entries (see all 27):

DT.95344633 DT.119195 DT.100845917 DT.95352178 DT.100845915 DT.100845910 DT.95352206 DT.97784070

DT.100845912 DT.100845913 DT.100845919 DT.121023162 DT.121023414 DT.92068163 DT.92457228 DT.95237355

DT.95352171 DT.100845914 DT.121023234 DT.121023413 DT.121023420 DT.92457220 DT.95147920 DT.95352090

24/953 AceView cDNA sequences (see all 953):

BI917046 BE256255 BU191444 BM825346 BQ924469 CB139215 BE894788 CB114010

BM856546 AW473332 BM771984 BM272656 BQ771566 BQ685210 BQ901140 BM461739

BX421459 BU077971 BQ668345 BM823598 BQ670094 BM545004 BQ433727 BU676609

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIB About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b
SP1:											-
SP2:							-				-
SP3:

ECgene alternative splicing isoforms for PPIB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPIB expression in normal human tissues (normalized intensities) PPIB embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACTCACTTT

About this image

PPIB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/4 selected tissues (see all 4) fully expand


Bone (Muscoskeletal System) fully expand to see all 7 entries
Endochondral Facial Bones
HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
sensory organ/ear/inner ear

Cartilage (Muscoskeletal System) fully expand to see all 4 entries
sensory organ/ear/inner ear

Neural Crest (Gastrulation Derivatives) fully expand to see all 3 entries
skeleton/cranium/chondrocranium

Lower Urinary Tract (Urinary System)
bladder

See PPIB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIB

SOURCE GeneReport for Unigene cluster: Hs.434937

SABiosciences Custom PCR Arrays for PPIB

Primer Products:		OriGene qPCR primer pairs and template standards for PPIB OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PPIB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIB gene from 10/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ppib^{1 , 5}	peptidylprolyl isomerase B^{1, 5}	90.12(n)¹ 93.98(a)¹		9 (35.69 cM)⁵ 19035¹ NM_011149.2¹ NP_035279.2¹ 66060169⁵
chicken (Gallus gallus)	Aves	PPIB¹	peptidylprolyl isomerase B (cyclophilin B)	80.84(n) 86.47(a)		396447 NM_205461.1 NP_990792.1
lizard (Anolis carolinensis)	Reptilia	PPIB⁶	Peptidyl-prolyl cis-trans isomerase	83(a)	1 ↔ 1	GL343490.1(417575-422070)
African clawed frog (Xenopus laevis)	Amphibia	ppib-prov²	peptidylprolyl isomerase B	76.63(n)		BC054168.1
zebrafish (Danio rerio)	Actinopterygii	wufa97f08²	Danio rerio cDNA clone MGC73214 IMAGE4790964, complete more	79.36(n)		BC059560.1
fruit fly (Drosophila melanogaster)	Insecta	CG2852^{1 , 3}	peptidyl-prolyl cis-trans isomerase³ CG2852¹	73(a) (best of 2)³ 68.17(n)¹ 67.5(a)¹		58F3³ 37591¹ NM_137851.3¹ NP_611695.1¹
worm (Caenorhabditis elegans)	Secernentea	cyp-5³ cyn-5¹	cyclophillin³ Protein CYN-5¹	71(a) (best of 4)³ 63.35(n)¹ 67.66(a)¹		I(15048595-15049564)³ 173374¹ NM_061223.4¹ NP_493624.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CPR5(YDR304C)⁴ CPR5¹	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of more⁴ Cpr5p¹	55.85(n)¹ 56.38(a)¹		4(1072557-1071880)⁴ 851898^{1, 4} NP_010590.3¹ NP_010590.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G55920¹	peptidyl-prolyl cis-trans isomerase	61.62(n) 65.45(a)		824758 NM_115450.3 NP_567029.1
rice (Oryza sativa)	Liliopsida	AK104772.1²	--	75.26(n)		AK104772.1

ENSEMBL Gene Tree for PPIB (if available)
TreeFam Gene Tree for PPIB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPIB gene

PPIH² PPIC² CWC27² PPWD1² PPIL4² PPIL2² PPIL3² PPIL1²

18/23 SIMAP similar genes for PPIB using alignment to 1 protein entry: PPIB_HUMAN(see all similar genes):

PPIC PPIA PPIE PPIH LOC402252 RANBP2

PPIL1 PPIF PPID PPIAL4A PPIAL4B PPIAL4C

PPIAL4D PPIAL4G PPIG NKTR PPWD1 PPIL3

PPIB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_063436⁴		Osteogenesis imperfecta 9 (OI9)⁴	--	see VAR_063436	2	M R	mis⁴		0	--	--	--	--
rs121434559^1,2	C	pathogenic¹	44510211(-)	`GCTCCC/TAGTTC`	2	Q *	stg¹		0	--	--	--	--
rs137853864^1,2	C	pathogenic¹	44516370(-)	`CAACAG/TGAAGG`	2	R M	mis¹		0	--	--	--	--
rs28720193^1,2	C	untested¹	44510170(-)	`GATGGC/GAAGCA`	2	G	syn¹		5		NS	188
rs2307247^1,2	C,F,H	untested¹	44513532(-)	`TTCACC/TAGGGG`	2	T	syn¹ ese³		12		NA NS EU	6725
rs11558595^1,2,4	C,F,H	untested¹	44515521(-)	`GCCGGG/TTGATC`	2	V L	mis¹ ese³		9		NS EA NA	762
rs4904^1,2	C,F,H	untested¹	44516333(-)	`GGGTCC/AGTCTT`	2	/S	syn¹ ese³		18		MN EA NS WA NA EU	7035
rs181848744^1,2		--	44508805(+)	`GTCAGC/GTGGGT`	1	--	ds500¹		0	--	--	--	--
rs3896787^1,2	H	--	44508952(+)	`ATTTAG/AAGGTA`	1	--	ds500¹		5		MN NS EA	562
rs186457893^1,2		--	44508983(+)	`ACATCA/CCTTAA`	1	--	ds500¹		0	--	--	--	--
rs3858911^1,2	C,H	--	44508993(+)	`ACATAG/AACTGG`	1	--	ds500¹		5		MN NS EA	602
rs62024248^1,2	C	--	44509002(+)	`GGAGGG/TTGGTG`	1	--	ds500¹		3		WA NA	122
rs140759049^1,2		--	44509090(+)	`CTGGGC/TAGCTC`	1	--	ds500¹		0	--	--	--	--
rs79170101^1,2	C,F	--	44509147(+)	`ATTGCC/TACAGG`	1	--	ds500¹		1		WA	118
rs202080377^1,2		--	44509227(+)	`ATATA-/TTTAAA`	1	--	ut3¹		0	--	--	--	--
rs113626158^1,2	C	--	44509242(+)	`AAAAAT/ACCCAC`	1	--	ut3¹		1		CSA	1
rs1043001^1,2	A,H	--	44509340(+)	`CACCAG/AATGCC`	1	--	ut3¹ ese³		4		NS EA	416
rs2230223^1,2	C,H	--	44509367(-)	`GCTCTG/CAGCTG`	1	--	ut3¹ ese³		6		MN NS EA EU	1051
rs9091^1,2	A	--	44509369(-)	`GGGCTC/TTGAGC`	1	--	ut3¹ ese³		3		MN NA	188
rs201075610^1,2	C	--	44509380(+)	`TGTGGC/TGGACT`	1	--	ut3¹		1		EU	1165
rs2307248^1,2	C,F,H	--	44509411(-)	`TTCTTT/AGAGTG`	1	--	ut3¹		9		NA NS EA WA	1292
rs201974607^1,2	C	--	44509418(+)	`AGAAAG/TATGTC`	1	--	ut3¹		1		EU	1309
rs200904948^1,2		--	44509455(+)	`AAAGGA/GCTTCT`	2	P S	mis¹		0	--	--	--	--
rs200864554^1,2	C	--	44509514(+)	`TATCCC/TGGCTG`	2	Q R	mis¹		0	--	--	--	--
rs112393084^1,2	C	--	44509556(+)	`CCTCCA/TGGAAA`	1	--	spa¹		1		CSA	1
rs2253557^1,2	C,F,A,H	--	44509575(+)	`GGAAGT/CAGGAG`	1	--	int¹		28		EA NA NS WA CSA EU	4735
rs191357754^1,2		--	44509627(+)	`CCAGCA/GTATGG`	1	--	int¹		0	--	--	--	--
rs41434449^1,2	C,F,H	--	44509670(+)	`AGCACA/TCAAAA`	1	--	int¹		20		NS EA NA	2034
rs150119910^1,2		--	44509734(+)	`TTTGAC/TGAGGG`	1	--	int¹		0	--	--	--	--
rs182294857^1,2		--	44509735(+)	`TTGACA/GAGGGG`	1	--	int¹		0	--	--	--	--
rs80308901^1,2	C,F	--	44509737(+)	`GACGAG/TGGGGT`	1	--	int¹		1		NA	120
rs3888854^1,2	C,H	--	44509802(-)	`ACCCTC/TTTCCT`	1	--	int¹ trp³		6		NS EA NA	598
rs138858242^1,2		--	44509827(+)	`GCTTCG/TCAGGG`	1	--	int¹		0	--	--	--	--
rs143219457^1,2	C	--	44509900(+)	`GAGGGA/GAGGGA`	1	--	int¹		0	--	--	--	--
rs147098192^1,2	C	--	44509963(+)	`ATTTAG/TAACCT`	1	--	int¹		0	--	--	--	--
rs138537382^1,2	C	--	44510104(+)	`ATTGCA/CCAGTA`	1	--	int¹		0	--	--	--	--
rs199606428^1,2		--	44510153(+)	`CTTTGC/TCAAAC`	2	D G	mis¹		0	--	--	--	--
rs201926681^1,2		--	44510169(+)	`ATGCTC/TGCCAT`	2	K E	mis¹		0	--	--	--	--
rs200990246^1,2		--	44510174(+)	`TGCCAC/TCTAGC`	2	D G	mis¹		0	--	--	--	--
rs140817860^1,2	C	--	44510196(+)	`GACTGT/CCGTGA`	2	/T /A	mis¹		1		NA	4552
rs11558597^1,2	C	--	44510290(-)	`TTCCCC/TGATGA`	2	P	syn¹ ese³		0	--	--	--	--
rs112753884^1,2	C	--	44510321(+)	`TTCCTC/GGGAAA`	1	--	int¹		0	--	--	--	--
rs28720192^1,2	C,F,H	--	44510345(-)	`GCGCCC/TCTGAC`	1	--	int¹		11		NS NA CSA WA	813
rs2241995^1,2	C,F,H	--	44510379(+)	`CATTCG/AGGGCC`	1	--	int¹		10		EA NS	2098
rs73462555^1,2	C,F	--	44510690(+)	`GGGTCG/AGAACT`	1	--	int¹		2		WA CSA	4
rs8032139^1,2	C,F,H	--	44510725(+)	`GCTGAC/TCAGCC`	1	--	int¹		16		NS EA NA WA	1398
rs12324206^1,2	C	--	44510728(+)	`GACCAC/GCCTGT`	1	--	int¹		0	--	--	--	--
rs28720191^1,2	C,F	--	44510896(-)	`GACGCG/CTCACA`	1	--	int¹		5		NS	188
rs147241860^1,2	C	--	44510919(+)	`GCTTGA/GGGATA`	1	--	int¹		0	--	--	--	--
rs3784381^1,2	C,F,A,H	--	44511049(+)	`TGCATG/TAGGCC`	1	--	int¹		34		EA NA NS WA CSA	4828
rs148722035^1,2		--	44511091(+)	`TCATTG/TTGTTT`	1	--	int¹		0	--	--	--	--
rs116378352^1,2	C,F	--	44511168(+)	`ATCCTG/ATGGTT`	1	--	int¹		1		WA	118
rs7177371^1,2	C,F,H	--	44511248(+)	`CAGCAG/AGTAGG`	1	--	int¹		22		NS EA NA WA	2520
rs190873800^1,2		--	44511302(+)	`AGGGTA/GCTTCT`	1	--	int¹		0	--	--	--	--
rs141454864^1,2		--	44511334(+)	`CCCACA/GCTGGG`	1	--	int¹		0	--	--	--	--
rs150852091^1,2		--	44511569(+)	`AGTTAG/TTCTTT`	1	--	int¹		0	--	--	--	--
rs183450369^1,2		--	44511610(+)	`TTGTCC/TCTACC`	1	--	int¹		0	--	--	--	--
rs187423775^1,2		--	44511617(+)	`TACCCA/CCTCCC`	1	--	int¹		0	--	--	--	--
rs193076306^1,2		--	44511629(+)	`ATGTAC/TTTACT`	1	--	int¹		0	--	--	--	--
rs201699492^1,2	C	--	44511647(+)	`TCCATC/TCCCAC`	1	--	int¹		0	--	--	--	--
rs73462557^1,2	C	--	44511715(+)	`TCCAAG/ACATCT`	1	--	int¹		1		WA	2
rs185324064^1,2		--	44511739(+)	`ATCCAC/TTCTAT`	1	--	int¹		0	--	--	--	--
rs28720190^1,2	C,F,H	--	44511807(-)	`CTGCTG/TGGGCT`	1	--	int¹		8		NS NA	516
rs149505645^1,2	C	--	44511847(+)	`GGTGG-/TCTGCT CTCGAATCTCTGC`	1	--	int¹		0	--	--	--	--
rs28720188^1,2	C,F	--	44511963(-)	`GGCAGA/GTCCAG`	1	--	int¹		6		NS WA	308
rs139548376^1,2		--	44512175(+)	`CTGCCC/TGTTCA`	1	--	int¹		0	--	--	--	--
rs28617359^1,2	C	--	44512241(+)	`CCCCCA/GTTCCC`	1	--	int¹		0	--	--	--	--
rs143367223^1,2		--	44512389(+)	`CAGAAA/CAGGAA`	1	--	int¹		0	--	--	--	--
rs28720187^1,2	C,F,H	--	44512469(-)	`CAGACG/ACAGTT`	1	--	int¹		20		NS EA NA	2176
rs114478852^1,2	F	--	44512591(+)	`ATGGGT/CCTTCA`	1	--	int¹		1		WA	118
rs192711932^1,2		--	44512652(+)	`CTGTGC/TTCTAA`	1	--	int¹		0	--	--	--	--
rs183476207^1,2		--	44512757(+)	`TCGGCA/CCTCAC`	1	--	int¹		0	--	--	--	--
rs115134044^1,2	C	--	44512781(+)	`GTGAAA/TGACTG`	1	--	int¹		0	--	--	--	--
rs139392480^1,2		--	44512943(+)	`TAACTA/GGGATT`	1	--	int¹		0	--	--	--	--
rs188205095^1,2		--	44512950(+)	`GATTAC/TAGGCG`	1	--	int¹		0	--	--	--	--
rs28720186^1,2	C,F	--	44512956(-)	`GGCACG/ACGCCT`	1	--	int¹		9		NS NA WA CSA	182
rs144878175^1,2		--	44513029(+)	`TGGTCG/TTGAAC`	1	--	int¹		0	--	--	--	--
rs181786003^1,2		--	44513102(+)	`CGCCTA/GGCCCT`	1	--	int¹		0	--	--	--	--
rs184615059^1,2		--	44513109(+)	`CCCTCA/TCACTC`	1	--	int¹		0	--	--	--	--
rs28720185^1,2	C,F	--	44513171(-)	`GGGTAC/TGCGAT`	1	--	int¹		7		NS NA	296
rs28720184^1,2	C,F,H	--	44513275(-)	`TGACCG/ATCCTG`	1	--	int¹		10		NS NA	680
rs28720183^1,2	C,F,H	--	44513370(-)	`ACCAGC/TGGCAC`	1	--	int¹		12		NS NA WA	1098
rs190531165^1,2		--	44513427(+)	`AGAAAA/GAGGCC`	1	--	int¹		0	--	--	--	--
rs112988616^1,2	C,F	--	44513581(+)	`GGAATT/CTGCTG`	2	/K /R	mis¹		1		NA	4552
rs28720182^1,2	C,F	--	44513772(-)	`GTCCTG/ATGGCG`	1	--	int¹		5		NS	188
rs28720181^1,2	C,F	--	44513813(-)	`ATGGAG/AGCAGA`	1	--	int¹		7		NS NA	308
rs186981162^1,2		--	44513848(+)	`CTACAC/TCACAT`	1	--	int¹		0	--	--	--	--
rs151166295^1,2		--	44513940(+)	`AAAGTC/TAATAT`	1	--	int¹		0	--	--	--	--
rs141275426^1,2	C	--	44514008(+)	`GTCTCA/CCCAGG`	1	--	int¹		0	--	--	--	--
rs147082159^1,2		--	44514084(+)	`GAGTTC/TCTCTC`	1	--	int¹		0	--	--	--	--
rs191249368^1,2		--	44514158(+)	`TCAAGC/TGATTC`	1	--	int¹		0	--	--	--	--
rs113977805^1,2	C,F	--	44514388(+)	`TTTTGA/CGATGG`	1	--	int¹		2		NA	122
rs138501770^1,2		--	44514420(+)	`GCTAGA/GGTGCA`	1	--	int¹		0	--	--	--	--
rs144061543^1,2		--	44514489(+)	`CTCAGC/TCTCCC`	1	--	int¹		0	--	--	--	--
rs181308945^1,2		--	44514531(+)	`CACCTC/GGCTAA`	1	--	int¹		0	--	--	--	--
rs150277449^1,2		--	44514625(+)	`CTCAGC/GCTCCC`	1	--	int¹		0	--	--	--	--
rs185176469^1,2	C	--	44514662(+)	`TACTGC/TGCCCG`	1	--	int¹		0	--	--	--	--
rs116602283^1,2	C,F	--	44514666(+)	`GCGCCC/TGGCCT`	1	--	int¹		2		WA EA	238
rs189939991^1,2		--	44514689(+)	`TAATTA/TATTTT`	1	--	int¹		0	--	--	--	--
rs182416935^1,2		--	44514708(+)	`GACAGG/TGTCTC`	1	--	int¹		0	--	--	--	--
rs138678524^1,2		--	44514732(+)	`GGCTGC/GAGTGC`	1	--	int¹		0	--	--	--	--
rs149353137^1,2		--	44514769(+)	`CCTCCA/GTTTCA`	1	--	int¹		0	--	--	--	--
rs189011562^1,2		--	44514844(+)	`AAAAAA/TTTTTT`	1	--	int¹		0	--	--	--	--
rs200356865^1,2		--	44514844(+)	`AAAAA-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs192121876^1,2		--	44514857(+)	`TGGCCA/GGGCAT`	1	--	int¹		0	--	--	--	--
rs113377532^1,2	C,F	--	44514994(+)	`CCAAGG/CGTGGT`	1	--	int¹		1		NA	2
rs139619111^1,2		--	44515002(+)	`GGTGGC/TGCATG`	1	--	int¹		0	--	--	--	--
rs142887140^1,2		--	44515112(+)	`CCAGGA/CGACAA`	1	--	int¹		0	--	--	--	--
rs76209527^1,2	C,F	--	44515134(+)	`CGTCTA/C/GAAAAA`	1	--	int¹		2		WA NA	4
rs117511166^1,2	C,F	--	44515274(+)	`TGCCTG/AGTCAG`	1	--	int¹		1		EA	120
rs139327663^1,2		--	44515287(+)	`CCCCAC/TTACTC`	1	--	int¹		0	--	--	--	--
rs144124801^1,2		--	44515320(+)	`TCCCAA/GGGCAA`	1	--	int¹		0	--	--	--	--
rs150590633^1,2	C	--	44515431(+)	`ACTACA/CCCTGC`	1	--	int¹		0	--	--	--	--
rs202059751^1,2	C	--	44515438(+)	`CTGCTC/TCAGCC`	1	--	int¹		0	--	--	--	--
rs200786931^1,2	C	--	44515458(+)	`TCCTGC/TAGCTA`	2	T A	mis¹		0	--	--	--	--
rs202087362^1,2	C	--	44515475(+)	`CAAAAT/CTATCC`	2	/N /S	mis¹		1		EU	1323
rs28720180^1,2	C	--	44515614(-)	`CTCCCC/TTAGCA`	1	--	int¹ trp³		6		NS NA	192
rs28720179^1,2	C,F	--	44515720(-)	`ATTCTC/TATAGG`	1	--	int¹		7		NS WA	310
rs112549894^1,2	C,F	--	44515808(+)	`GCTCTG/AAACAG`	1	--	int¹		1		CSA	2
rs28720178^1,2	C,F	--	44515854(-)	`CCTTAT/AGGGTT`	1	--	int¹		9		NS NA	316
rs143999469^1,2	C	--	44515959(+)	`CGGAA-/TCCGGC`	1	--	int¹		0	--	--	--	--
rs183473433^1,2	C	--	44516213(+)	`AGGCCG/TCCCGG`	1	--	int¹		0	--	--	--	--
rs137883097^1,2	F	--	44516272(+)	`GGTGAC/TTTTGG`	2	I V	mis¹		1		NA	3964
rs200307684^1,2	C	--	44516311(+)	`AGGTCC/TCGGCA`	2	R G	mis¹		0	--	--	--	--
rs141504929^1,2	F	--	44516387(+)	`GAGAGG/ACGCAG`	2	/R	syn¹		1		NA	3992
rs188404221^1,2	C	--	44516415(+)	`GAAAGC/TAGCCC`	1	--	ut5¹		0	--	--	--	--
rs191528507^1,2		--	44516475(+)	`CGCCGA/CCACGC`	1	--	ut5¹		0	--	--	--	--
rs112481305^1,2	C,F	--	44516566(+)	`TAGTAG/AGTCCC`	1	--	us2k¹		1		NA	2
rs113066141^1,2	C,F	--	44516576(+)	`CCCTGC/TGGGGC`	1	--	us2k¹		1		NA	2
rs184062676^1,2		--	44516621(+)	`TTATTA/GCTCCC`	1	--	us2k¹		0	--	--	--	--
rs12912864^1,2	C	--	44516691(+)	`TCGCAA/GAGCAC`	1	--	us2k¹		0	--	--	--	--
rs28720177^1,2	C,F	--	44516826(-)	`TTCCCG/CTGCCC`	1	--	us2k¹		5		NS	174
rs28720176^1,2	C,F	--	44516980(-)	`AGTGGG/TTTGTG`	1	--	us2k¹		9		NS NA WA	294
rs148695759^1,2	C	--	44516989(+)	`CTTCC-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs191227283^1,2		--	44517029(+)	`TCTCTC/GCCTTC`	1	--	us2k¹		0	--	--	--	--
rs28720174^1,2	C	--	44517033(-)	`TACAGA/GAGGGA`	1	--	us2k¹ trp³		6		NS WA	290
rs28720173^1,2	C	--	44517114(-)	`GGGGGA/GAAAGG`	1	--	us2k¹ tfbs³ trp³		5		NS	172
rs28720172^1,2		--	44517155(-)	`ACAGTC/TCCTTC`	1	--	us2k¹		5		NS	174
rs142196049^1,2	C	--	44517213(+)	`GTGCC-/CAACAAGT`	1	--	us2k¹		0	--	--	--	--
rs28720171^1,2	C,F	--	44517216(-)	`GACTTG/TTTGGG`	1	--	us2k¹		7		NS WA NA	184
rs145150154^1,2		--	44517334(+)	`CACAGA/GGCTAT`	1	--	us2k¹		0	--	--	--	--
rs3848146^1,2	C,H	--	44517371(-)	`GTAGAG/TTGGGA`	1	--	us2k¹		11		NS NA WA CSA	138
rs28720169^1,2	C,F	--	44517398(-)	`GACTCC/GCAGTA`	1	--	us2k¹		6		NS EA	310
rs142543311^1,2		--	44517610(+)	`CCACTG/TGCATT`	1	--	us2k¹		0	--	--	--	--
rs7182202^1,2	C,F,H	--	44517646(+)	`TTACAC/TAGGTT`	1	--	us2k¹		8		NS EA NA WA	812
rs28720168^1,2	C,F,H	--	44517733(-)	`TAACAA/GTGTTT`	1	--	us2k¹		12		NS NA WA	1092
rs372292315^1,2	C	--	44517778(+)	`ATCCCC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs143373009^1,2		--	44517856(+)	`AAAATA/GTTTAC`	1	--	us2k¹		0	--	--	--	--
rs190635085^1,2		--	44517934(+)	`AGAGGC/TTGTGG`	1	--	us2k¹		0	--	--	--	--
rs182149943^1,2		--	44518007(+)	`AAAAAC/TACAAA`	1	--	us2k¹		0	--	--	--	--
rs185121618^1,2		--	44518036(+)	`GTGCGC/TATCTG`	1	--	us2k¹		0	--	--	--	--
rs148374464^1,2		--	44518194(+)	`GAGGAA/GCTAAG`	1	--	us2k¹		0	--	--	--	--
rs140651416^1,2	C	--	44518307(+)	`TTCCAC/GTGCTA`	1	--	us2k¹		0	--	--	--	--
rs35823554^1,2	C	--	44518528(+)	`TGTTCT/-ACCAC`	1	--	us2k¹		1		NA	2
rs117414060^1,2	C,F	--	44518530(+)	`TTCTAC/GCACCT`	1	--	us2k¹		1		NA	120
rs117831796^1,2	F	--	44518531(+)	`TCTACC/GACCTG`	1	--	us2k¹		1		NA	120
rs74671030^1,2	C,F	--	44518538(+)	`CCTGAG/CAACAA`	1	--	us2k¹		3		CSA WA EA	240
rs34573087^1,2	C	--	64455920(+)	`CATTT-/T/TT TTTTT`	1	--	us2k¹		0	--	--	--	--
rs28720170^1,2	F	--	64456006(-)	`AGGACTT/-GTTGG`	1	--	us2k¹		5		NS	184
rs10617195^1,2	C	--	64456567(+)	`CTTTT-/T/TT TTTTT`	1	--	us2k¹		1		NA	2
rs7182032^1,2	--	--	44517566(+)	`GTAGTC/GTTCAT`	1	--	us2k¹		0	--	--	--	--
rs71394543^1,2	--	--	44508998(+)	`GACTGG/AAGGGT`	1	--	ds500¹		1		NA	2
rs375647035^1,2	--	--	44515211(+)	`GGGCTC/TAGCAA`	1	--	int¹		0	--	--	--	--
rs372252231^1,2	--	--	44510347(+)	`CAGGGA/GCGCTG`	1	--	int¹		0	--	--	--	--
rs367616150^1,2	--	--	44516404(+)	`CAGGCC/GGAGGC`	1	--	ut5¹		0	--	--	--	--
rs34148786^1,2	--	--	44518337(+)	`TAAAG-/CAGTAG`	1	--	us2k¹		0	--	--	--	--
rs28720175^1,2	--	--	44517032(-)	`ACAGAA/CGGGAG`	1	--	us2k¹ trp³		5		NS	172
rs3056904^1,2	--	--	44508921(-)	`ttttt-/TTTTTT TTTTTTTTTggtag`	1	--	ds500¹		0	--	--	--	--
rs138741187^1,2	--	--	44510305(+)	`TCACCG/ATAGAT`	2	/Y	syn¹		1		NA	4550
rs373618000^1,2	--	--	44510263(+)	`GGCCCA/GTAGTG`	2	Y	syn¹		0	--	--	--	--
rs374880244^1,2	--	--	44510335(+)	`GACAGA/TGCAGG`	1	--	int¹		0	--	--	--	--
rs137853866^1,2	--	untested¹	44513543(-)	`AGGGCA/GGAGAC`	2	R G	mis¹		0	--	--	--	--
rs369831615^1,2	--	--	44510639(+)	`GGAGGG/TCTTTG`	1	--	int¹		0	--	--	--	--
rs142381852^1,2	--	--	44509431(+)	`TGTGCC/GCTACT`	1	--	ut3¹		1		NA	4552
rs28720189^1,2	--	--	44511899(-)	`GGGCAG/TGGAGA`	1	--	int¹		5		NS	190
rs1804426^1,2	--	--	44509353(-)	`TGGCCC/TCGGTG`	1	--	ut3¹		0	--	--	--	--
rs137853867^1,2	--	untested¹	44513512(-)	`AGGAGA/GTAACC`	1	--	spd¹		0	--	--	--	--
rs367916633^1,2	--	--	44509398(+)	`CTGCAC/TAGACG`	1	--	ut3¹		0	--	--	--	--
rs112726573^1,2	--	--	44513179(+)	`CCCACAT/-GTCTT`	1	--	int¹		1		CSA	2
rs1803362^1,2	--	--	44509327(-)	`GCGGAA/CCCACT`	1	--	ut3¹		0	--	--	--	--
rs202116920^1,2	--	--	44509351(+)	`AGCACC/TGGGGC`	1	--	ut3¹		1		EU	581
rs151284742^1,2	--	--	44510143(+)	`CCCTCT/CAGAAC`	2	/L	syn¹		1		NA	4552
rs35638198^1,2	--	--	44514326(+)	`GTGCT-/GGGGAT`	1	--	int¹		0	--	--	--	--
rs369181494^1,2	--	--	44509605(+)	`TCCACC/TGCTCA`	1	--	int¹		0	--	--	--	--
rs200779927^1,2	--	--	44514311(+)	`TCCTCC/TGCCTC`	1	--	int¹		0	--	--	--	--
rs372796450^1,2	--	--	44513640(+)	`GTGGTA/GTGGGG`	1	--	int¹		0	--	--	--	--
rs372323694^1,2	--	--	44514665(+)	`TGCGCC/TGGCCT`	1	--	int¹		0	--	--	--	--
rs34415481^1,2	--	--	44514973(+)	`CTACT-/AAAAAT`	1	--	int¹		0	--	--	--	--
rs377032173^1,2	--	--	44509578(+)	`AGCAGA/GAGGGC`	1	--	int¹		0	--	--	--	--
rs137853865^1,2	--	untested¹	44516276(-)	`GGGCC-/CAAAGT`	2	S V	fra¹		0	--	--	--	--
rs369334476^1,2	--	--	44510197(+)	`ACTGTC/TTGATG`	2	T	syn¹		0	--	--	--	--
rs368728857^1,2	--	--	44514659(+)	`AGTTAC/TGCGCC`	1	--	int¹		0	--	--	--	--
rs1804427^1,2	--	--	44509463(-)	`CGAGGC/TGGAGA`	2	A V	mis¹		0	--	--	--	--
rs137853869^1,2	--	untested¹	44509524(-)	`GCACC-/AAGA CAGAC`	2	Q KT	fra¹		0	--	--	--	--
rs368454186^1,2	--	--	44513585(+)	`TTTGCC/TGTTTT`	2	S G	mis¹		0	--	--	--	--
rs373715158^1,2	--	--	44515560(+)	`AAAATA/GCACCT`	2	H Y	mis¹		0	--	--	--	--
rs374723458^1,2	--	--	44516089(+)	`GCAGGA/GCTGGG`	1	--	int¹		0	--	--	--	--
rs375891105^1,2	--	--	44514644(+)	`GGGACC/TCAGGC`	1	--	int¹		0	--	--	--	--
rs377084281^1,2	--	--	44513482(+)	`CTGACA/GTACTC`	1	--	int¹		0	--	--	--	--
rs368514865^1,2	--	--	44516223(+)	`GGCCCA/GAGCTC`	1	--	int¹		0	--	--	--	--
rs199971446^1,2	--	--	44513518(+)	`CTCCTA/GTGCCA`	2	T I	mis¹		0	--	--	--	--
rs370932084^1,2	--	--	44515465(+)	`GCTAAA/GGCCAC`	2	A	syn¹		0	--	--	--	--
rs367847142^1,2	--	--	44514112(+)	`GTGCAA/GGGCAC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPIB (64448011 - 64455404 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for PPIB: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833036	CNV	Loss	17160897
nsv827360	CNV	Loss	20364138

Human Gene Mutation Database (HGMD): PPIB

Locus Specific Mutation Databases (LSDB): PPIB

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing PPIB

DNA2.0 Custom Variant and Variant Library Synthesis for PPIB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 123841
OMIM disorders: 259440
UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue

disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma.

Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality.

Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing

loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. Note=The disease is caused by

mutations affecting the gene represented in this entry

19 diseases for PPIB: About MalaCards

syphilis dentinogenesis imperfecta dwarfism connective tissue disease

nephrotic syndrome encephalitis multiple myeloma myeloma

hepatitis c b-cell lymphomas hepatocellular carcinoma pancreatic cancer

hepatitis pancreatitis breast cancer

1 disease from the University of Copenhagen DISEASES database for PPIB:

Osteogenesis imperfecta

PPIB for disorders About GeneDecksing

Genetic Association Database (GAD): PPIB
Human Genome Epidemiology (HuGE) Navigator: PPIB (1 document)

Export disorders for PPIB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPIB gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with PPIB)

Utopia: connect your pdf to the dynamic
world of online information

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PubMed id 2000394)^{1, 2, 3, 9} Price E.R....Walsh C.T. (1991)
Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PubMed id 20089953)^{1, 2, 3, 9} Barnes A.M....Marini J.C. (2010)
PPIB mutations cause severe osteogenesis imperfecta. (PubMed id 19781681)^{1, 2, 9} van Dijk F.S.... Pals G. (2009)
A novel secreted cyclophilin-like protein (SCYLP). (PubMed id 2040592)^{1, 2, 9} Spik G.... Movva N.R. (1991)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. (PubMed id 8197205)^{1, 2} Mikol V.... Walkinshaw M.D. (1994)
S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. (PubMed id 1530944)^{1, 2} Arber S.... Caroni P. (1992)
Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)^{1, 2} Rasmussen H.H....Vandekerckhove J. (1992)
An endoplasmic reticulum-specific cyclophilin. (PubMed id 1710767)^{1, 2} Hasel K.W.... Sutcliffe J.G. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5479	HGNC: 9255	AceView: PPIB	Ensembl:ENSG00000166794	euGenes: HUgn5479
ECgene: PPIB	H-InvDB: PPIB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPIB	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/ppib/
Osteogenesis imperfecta variant database	http://oi.gene.le.ac.uk/home.php?select_db=PPIB

Intellectual Property for PPIB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PPIB gene:
Search GeneIP for patents involving PPIB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore small molecules (inhibitor) for PPIB

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for PPIB (Cyclophilin B)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for PPIB
	OriGene qPCR primer pairs and template standards for PPIB		OriGene Protein Over-expression Lysate for PPIB
	OriGene MassSpec something-or-other for PPIB		OriGene clones in human, mouse for PPIB
	OriGene qSTAR qPCR primer pairs in human, mouse for PPIB		OriGene Purified Protein for PPIB
	OriGene ORF clones in mouse, rat for PPIB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PPIB		OriGene Custom Protein Services for PPIB

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPIB
	QIAGEN SeqTarget long-range PCR primers for resequencing PPIB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB

	GenScript Custom Purified and Recombinant Proteins Services for PPIB		GenScript cDNA clones with any tag delivered in your preferred vector for PPIB
	GenScript Custom Assay Services for PPIB		GenScript Custom Superior Antibodies Services for PPIB
	GenScript Custom overexpressing Cell Line Services for PPIB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PPIB promoter
	Search Chromatin IP Primers for PPIB
	RT² qPCR Primer Assay in human, mouse, rat PPIB
	GNC Network for PPIB
	SABiosciences Custom PCR Arrays for PPIB

Search Tocris compounds for PPIB

	Proteins and Antibodies for PPIB
	Cell Lysates for PPIB
	cDNA Clones for PPIB
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PPIB antibodies
	PPIB proteins
	PPIB lysates

	Antibodies for PPIB
	See all of Abcam's Antibodies, Kits and Proteins for PPIB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for PPIB

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for PPIB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

	SwitchGear 3'UTR luciferase reporter plasmids for PPIB
	SwitchGear Promoter luciferase reporter plasmids for PPIB

ThermoFisher Antibody for PPIB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB

	inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIB
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPIB

Customized:

	lentivirus for stable overexpression of PPIB
	lentivirus expression plasmids for stable overexpression of PPIB
	adenovirus for overexpression of PPIB

LSBio Antibodies in human, mouse, rat for PPIB

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PPIB gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

PPIB Gene

Peptidylprolyl Isomerase B (Cyclophilin B)

Aliases
for PPIB gene

Summaries
for PPIB gene

Genomic Views
for PPIB gene

Proteins
for PPIB gene

Protein Domains /
Families
for PPIB gene

Function
for PPIB gene

Pathways & Interactions
for PPIB gene

Drugs & Compounds
for PPIB gene

Transcripts
for PPIB gene

Expression
for PPIB gene

Orthologs
for PPIB gene

Paralogs
for PPIB gene

Genomic Variants
for PPIB gene

Disorders / Diseases
for PPIB gene

Publications
for PPIB gene

External Searches for PPIB gene

Genome Databases showing PPIB gene

Other Databases showing PPIB gene

Specialized Databases showing PPIB gene

Intellectual Property
for PPIB gene

Products
for PPIB gene

View Random Gene

Advanced Search

Export list of displayed genes

PPIB Gene

Peptidylprolyl Isomerase B (Cyclophilin B)

Aliasesfor PPIB gene

Summariesfor PPIB gene

Genomic Viewsfor PPIB gene

Proteinsfor PPIB gene

Protein Domains /Familiesfor PPIB gene

Functionfor PPIB gene

Pathways & Interactionsfor PPIB gene

Drugs & Compoundsfor PPIB gene

Transcriptsfor PPIB gene

Expression for PPIB gene

Orthologsfor PPIB gene

Paralogsfor PPIB gene

Genomic Variantsfor PPIB gene

Disorders / Diseasesfor PPIB gene

Publicationsfor PPIB gene

External Searches for PPIB gene

Genome Databases showing PPIB gene

Other Databases showing PPIB gene

Specialized Databases showing PPIB gene

Intellectual Propertyfor PPIB gene

Productsfor PPIB gene

View Random Gene

Aliases
for PPIB gene

Summaries
for PPIB gene

Genomic Views
for PPIB gene

Proteins
for PPIB gene

Protein Domains /
Families
for PPIB gene

Function
for PPIB gene

Pathways & Interactions
for PPIB gene

Drugs & Compounds
for PPIB gene

Transcripts
for PPIB gene

Expression
for PPIB gene

Orthologs
for PPIB gene

Paralogs
for PPIB gene

Genomic Variants
for PPIB gene

Disorders / Diseases
for PPIB gene

Publications
for PPIB gene

Intellectual Property
for PPIB gene

Products
for PPIB gene