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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIB Gene

protein-coding   GIFtS: 75
GCID: GC15M064448

Peptidylprolyl Isomerase B (Cyclophilin B)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase B (Cyclophilin B)1 2     PPIase B2 3
CYPB2 3 5     EC 5.2.1.83 8
Rotamase B2 3     OI92 5
CYP-S12 3     Cyclophilin-Like Protein2
S-cyclophilin2 3     Peptidyl-Prolyl Cis-Trans Isomerase B2
SCYLP2 3     Cyclophilin B3

External Ids:    HGNC: 92551   Entrez Gene: 54792   Ensembl: ENSG000001667947   OMIM: 1238415   UniProtKB: P232843   

Export aliases for PPIB gene to outside databases

Previous GC identifers: GC15M060234 GC15M057607 GC15M062026 GC15M062163 GC15M062235 GC15M041272


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIB Gene:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic
reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind
to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants
have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. (provided by
RefSeq, Oct 2009)

GeneCards Summary for PPIB Gene: 
PPIB (peptidylprolyl isomerase B (cyclophilin B)) is a protein-coding gene. Diseases associated with PPIB include ppib-related osteogenesis imperfecta, and osteogenesis imperfecta type 9, and among its related super-pathways are Collagen formation and BAFF in B-Cell Signaling. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIB gene promoter:
         Bach1   AP-1   Tal-1   E47   AREB6   FAC1   Pax-3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIB promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q21-q22

PPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064448:  view genomic region     (about GC identifiers)

Start:
64,448,011 bp from pter      End:
64,455,404 bp from pter
Size:
7,394 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase B precursor  
Size: 216 amino acids; 23743 Da
Subunit: Interacts with DYM
Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAA52150.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for PPIB:
1CYN (3D)        3ICH (3D)        3ICI (3D)    
Secondary accessions: A8K534 Q6IBH5 Q9BVK5

Explore the universe of human proteins at neXtProt for PPIB: NX_P23284

Explore proteomics data for PPIB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23284

  • 4/10 DME Specific Peptides for PPIB (P23284) (see all 10)
     GGKSIYG  FMIQGGD  GKTVPKT  TNGSQFF 

    PPIB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPIB Protein Expression
    REFSEQ proteins: NP_000933.1  
    ENSEMBL proteins: 
     ENSP00000300026  
    Reactome Protein details: P23284
    Human Recombinant Protein Products for PPIB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPIB
    OriGene Protein Over-expression Lysate for PPIB
    OriGene MassSpec for PPIB 
    OriGene Custom Protein Services for PPIB
    GenScript Custom Purified and Recombinant Proteins Services for PPIB
    Novus Biologicals PPIB Proteins
    Novus Biologicals PPIB Lysate
    Sino Biological Recombinant Protein for PPIB
    Sino Biological Cell Lysate for PPIB 
    ProSpec Recombinant Protein for PPIB
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS2000394
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0042470melanosome IEA--

    PPIB for ontologies           About GeneDecksing



    PPIB Antibody Products: 
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    Novus Biologicals PPIB Antibodies
    Abcam antibodies for PPIB
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for PPIB
    LSBio Antibodies in human, mouse, rat for PPIB 

    Assay Products for PPIB: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPIB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P23284

    ProtoNet protein and cluster: P23284

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIB_HUMAN, P23284
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB

         Genatlas biochemistry entry for PPIB:
    peptidyl-propyl isomerase B

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity NAS2000394
    GO:0005515protein binding IPI15095401
    GO:0042277peptide binding IEA--
    GO:0051082unfolded protein binding TAS2000394
         
    PPIB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPIB:
     Increased G1 DNA content  Increased HPV18 LCR reporter a  Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppib):
     growth/size  integument  mortality/aging  no phenotypic analysis  skeleton 

    PPIB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppibtm1.1Rjb for PPIB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPIB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIB 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPIB:
    hsa-mir-1 (MIRT001347)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidPPIB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of PPIB

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for PPIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
    Sino Biological Human cDNA Clone for PPIB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
    Sirion Biotech Customized lentivirus for stable overexpression of PPIB 
                         Customized lentivirus expression plasmids for stable overexpression of PPIB 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PPIB
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPIB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Extracellular matrix organization0.39
    Collagen formation0.74
    2BAFF in B-Cell Signaling
    Apoptosis and survival APRIL and BAFF signaling0.39
    3Development Prolactin receptor signaling
    Prolactin Signaling Pathway0.39
    4Syndecan-1-mediated signaling events
    Syndecan-1-mediated signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PPIB
        Apoptosis and survival APRIL and BAFF signaling


    1 GeneGo (Thomson Reuters) Pathway for PPIB
        Apoptosis and survival APRIL and BAFF signaling

    2 BioSystems Pathways for PPIB
        Prolactin Signaling Pathway
    Syndecan-1-mediated signaling events


    3        Reactome Pathways for PPIB
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Collagen formation



    PPIB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/60 Interacting proteins for PPIB (P232842, 3 ENSP000003000264) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF1Q130772, 3MINT-49520 I2D: score=2 
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization NAS2000394
    GO:0006457protein folding IEA--
    GO:0030198extracellular matrix organization TAS--

    PPIB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPIB for compounds           About GeneDecksing

    EMD Millipore small molecules for PPIB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIB

    1 HMDB Compound for PPIB    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    2 DrugBank Compounds for PPIB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3targetbinder17139284 11752352 17016423
    1,4-Dithiothreitol-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PPIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclosporin a 69.9 42 9378502 (4), 10386979 (4), 8713086 (3), 11955071 (2) (see all 19)
    heparan sulfate 56.2 21 19940140 (4), 17588944 (4), 15109301 (4)
    proline 38.6 5 19781681 (2), 17630507 (1)
    anti-fungal 24.4 3 15245883 (1), 11848297 (1), 11732686 (1)
    heparin 22.8 6 15109301 (4), 19940140 (1)

    Search CenterWatch for drugs/clinical trials and news about PPIB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIB gene: 
    NM_000942.4  

    Unigene Cluster for PPIB:

    Peptidylprolyl isomerase B (cyclophilin B)
    Hs.434937  [show with all ESTs]
    Unigene Representative Sequence: BQ049986
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300026(uc002and.3) ENST00000558492 ENST00000561048(uc010bgx.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidPPIB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB
    Clone
    Products:
         
    OriGene clones in human, mouse for PPIB (see all 7)
    OriGene ORF clones in mouse, rat for PPIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
    Sirion Biotech Customized lentivirus for stable overexpression of PPIB 
                         Customized lentivirus expression plasmids for stable overexpression of PPIB 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB

    Additional mRNA sequence: 

    AK291149.1 AK311074.1 BC001125.2 BC008848.2 BC020800.1 BC032138.2 CR456829.1 M60457.1 
    M60857.1 M63573.1 

    24/27 DOTS entries (see all 27):

    DT.95344633  DT.119195  DT.100845917  DT.95352178  DT.100845915  DT.100845910  DT.95352206  DT.97784070 
    DT.100845912  DT.100845913  DT.100845919  DT.121023162  DT.121023414  DT.92068163  DT.92457228  DT.95237355 
    DT.95352171  DT.100845914  DT.121023234  DT.121023413  DT.121023420  DT.92457220  DT.95147920  DT.95352090 

    953 AceView cDNA sequences (see top 24):

    BI917046 BE256255 BU191444 BM825346 BQ924469 CB139215 BE894788 CB114010 
    BM856546 AW473332 BM771984 BM272656 BQ771566 BQ685210 BQ901140 BM461739 
    BX421459 BU077971 BQ668345 BM823598 BQ670094 BM545004 BQ433727 BU676609 
    AI858237 BX365792 CR591528 AA371710 BG291432 H28029 BM832180 AW069876 
    CF527923 BI833663 BM738655 BM830946 CA445299 BM823599 CB133821 AU076585 
    CD724155 BE385011 BM770117 BC001125 BQ683403 BQ690831 BF968021 BM543386 
    BM848908 BM473022 D79125 CF127720 CR599100 CA413148 BG119580 BM851207 
    BM825696 CF552399 BU179578 BE907521 BM826368 BU943933 BU839052 BM836056 
    BC032138 BM461482 BM831044 BM468509 BM802364 BP338061 BM830823 BM790287 
    BE383131 BQ639266 D28465 BQ221928 BM830815 BU184930 BM818902 CA489107 
    BQ223180 BM831116 BM757927 NM_000942 BX377936 BP375499 BM761921 CA865787 
    CA843122 H64623 BM831000 BQ681132 BM819645 BQ678793 BQ214119 BQ646775 
    BI518759 BM829980 BU849690 BM771388 BM747383 BI823156 BM848839 BU623904 
    CA843061 BM503216 BU507664 BX335040 BI768795 BM848965 BM830826 BM969712 
    BM756176 BM781952 BM825548 BQ637087 AJ712593 BM829960 CR595940 BM785350 
    BU078219 BM830995 BM826746 BM741113 BM830965 BX374937 BQ439218 BG118764 
    CR617864 H38201 BM818959 AA319269 BU181167 BM772843 CR616922 BM823645 
    BM851282 BQ878185 BQ020844 CN484237 CA448042 BM825654 BU187796 BF971354 
    BQ276360 BE899138 BI193214 BX401962 BG282122 BI197316 BX482168 BQ653613 
    BU940003 BG327625 AA377557 BM856579 AA311048 BF339798 BQ880301 BU196914 
    BG823250 BU788100 BI857296 AA345407 BF035338 BU624925 BM739767 BE260225 
    CF126200 BU633828 BG618047 BE730825 BM503374 CB116900 BI089125 BU839248 
    CF130025 BQ648298 CB106378 BE905033 BF968636 BG249903 AW406435 BG026799 
    CD388413 BU929305 BM051089 BI196530 H70129 BI856449 BI256493 BG169125 
    BE728460 BE274864 BG253457 AI874282 BE314030 BX344244 BQ644076 CD050701 
    AA330749 BM831076 CD050826 BM819053 BE906113 BG110524 BQ315874 BQ681722 
    BM759975 CN484467 BQ772065 N31525 CD050010 BF342405 BE893911 BQ673173 
    AA405732 BF309091 CD609869 BU959591 BF964982 BF343720 BG110675 BE293308 
    BG117367 BE873914 CB051872 BG028089 BQ083380 CA772674 BE880221 BI899381 
    BE788244 BG437068 BX336068 BQ439492 CA865535 BG765546 AA340927 BQ223864 
    CD673082 CB116464 BM848984 BI868399 AU132947 BG113551 CD686825 CD049229 
    BU077713 AL521566 AI151195 BE264281 BG548669 BM887628 BM835580 BM755843 
    BM475006 BM041158 CB986403 BP381408 AI799707 BF310299 BG481674 BQ437033 
    BU615466 BG255203 BE728134 BE386706 BP371882 BE782221 BP431981 CF527728 
    BM926444 BE909568 BM820054 BM272895 BG179337 BQ574222 CB962043 H30503 
    BQ679216 BM738623 BM717788 BF038254 T59969 CB990563 BM262991 BM768568 
    BG420509 BG110483 BE075903 BU659072 BI199509 BE263605 BM006218 CA775273 
    BU157311 BP354038 BM851084 BG290784 AA505769 BE789501 BE796018 CD690911 
    BM021931 BU622788 CD385020 CB128818 BP351947 BG165408 BQ931949 BU188767 
    BQ878872 BF315869 BF344914 BI196945 CD386312 BP378424 BF206217 BU598742 
    BG770302 BM823492 BM739874 M63573 BQ653229 BP338318 BC008848 BG763893 
    BG481831 BG119773 BG564418 BM850013 BM825566 AA335419 BI093128 BE902660 
    BU191134 BM142568 BE548415 BG105366 BM769844 BQ315859 M60857 H64624 
    AA341690 AV721524 BG288717 BM771483 BE878321 BG539632 BM745526 CA309810 
    BG748922 BE255596 BM756280 AA300553 BM041233 CN481652 BQ706762 BE868117 
    BE256823 BG482579 BG470050 AA041378 AU154376 N78663 BP343660 AA300659 
    CN484797 CD389773 BC020800 BM835251 BG475584 BQ430181 BF793179 H96665 
    BG115754 CD386080 BF182790 BU784431 N72032 BU595602 BM850020 BE786312 
    AW157859 R70193 BG168389 BQ083591 BX333970 BQ329053 BM015421 CR456829 
    BE904789 BG387361 M60457 N95711 BX425717 BG567814 BG035773 BQ374372 
    AI658746 BP379599 BQ372980 W44943 BF529521 BE905838 BE732386 BF691775 
    AV724041 AA932533 BU682447 AA347215 BF680267 BF793392 BE258630 BM468510 
    H70130 BQ299727 BP872633 AA460292 BG874438 AI685522 BI763882 BF477830 
    BG928837 BF315104 BU580049 AA683180 BG420584 H70141 AI672900 CD609873 
    T29872 CD609868 AI911809 BG945633 BQ315861 BM476206 BQ226846 BQ354470 
    BG115817 H25499 AW072107 BE621592 CD246311 BE251888 CA418454 AI669237 
    BQ367685 BQ351202 BM565074 CA775540 AI636813 BF665289 N42464 H37980 
    BE313764 BE877408 BG545610 BF183186 BQ315855 BM685680 BM825509 BQ347571 
    BQ299713 BM823548 BM973687 BG422084 N25666 BM755740 AV750982 W46569 
    BU630895 CB215100 AI658831 BF315441 BQ005529 AI873651 BI051205 BM047490 
    BF668331 BQ330165 BE898712 CA419223 BM856685 BQ299714 BM851173 BF313550 
    CD050905 AW950229 BE547745 AW474648 N71262 BG104995 BG169445 CA414623 
    BE563888 AL552931 BG475458 BF304364 BQ379404 BG104944 BU532171 CD696739 
    U95646 H39510 AA676347 BI001682 BI198310 BG981980 BF679612 AI752964 
    BF340314 AA464356 AW079732 AV748748 AA339534 BE735901 BM918271 BE875197 
    BG997079 BQ374809 W39593 BG996152 AI244252 BX397928 BG028967 AL708511 
    AA344939 CB857767 BQ299724 BP431706 N21510 BF089971 AV748753 AV695742 
    BQ271199 BQ299723 BM662924 AW860560 H96541 W25031 BG117924 H15847 
    AI140261 BG776550 BG953633 BQ292310 BQ299738 BG945656 CD693994 CD689917 
    BP340234 BI051204 BI042874 BG328002 AA923066 AA375124 AA617719 BQ367684 
    BI001523 BQ299725 BG993780 W59941 BU625179 AI288096 BQ299715 BG259878 
    BF576741 BG945650 BG751727 AI200522 BQ299749 BP373413 BU590106 BF982353 
    BP371908 BQ676206 AV686370 CA306896 CD684224 H16158 BQ373065 CB164678 
    BM691172 AA195473 AI189989 AV691528 AI927851 BQ362378 AA152179 BM770456 
    BI051185 CD693579 N71712 BQ315851 C02618 BU565775 AA088511 T59878 
    BQ299711 R73752 BQ315862 BF669408 H25156 AA126478 CD706592 BU940771 
    BM706502 AJ707255 CA437566 CD700319 BG945669 BF697543 BE960835 R83778 
    BG981672 BE503528 BG945673 BF700293 BG945657 BF174843 BF668401 BP379828 
    BF793965 BQ299733 BG945632 AA291447 CD689528 BU185244 BG945647 BF174092 
    AA354385 BG945652 BI051190 N79560 BM818934 BQ299752 BQ299717 BG945668 
    N80056 BQ299726 BU951595 AW276899 BI021785 C18577 D53319 BQ299751 
    AI001215 BQ367200 BI524022 BQ299736 BF673819 R83344 N75425 AA037187 
    BG945677 AA595399 N22863 BG945666 N25489 BG996215 BQ299737 BQ329253 
    BG983775 BG878498 BF095629 BG945653 AA976043 N20397 BG945644 AW243746 
    BG945665 AI027038 BF312219 BG945636 H25500 BQ378568 BQ352860 BQ271498 
    BG945641 AA632629 BQ299745 BG945638 BG164948 BQ379576 AA576737 AV708851 
    BG945645 BI004999 BG998132 BI051191 BI042871 BQ299740 BM748936 BI051178 
    BI194594 BF677004 R33096 BQ359808 BG945660 BI051182 BG008936 BI024043 
    BX438964 H22238 BQ299712 AA304961 AI984852 AW977236 BG945663 BQ350975 
    CA418669 BQ299747 AI190054 AA928475 CD707851 BI042673 BI042868 BQ292182 
    BQ299744 BQ051158 W46988 AI524956 BQ299735 BG008947 AA868208 CB051873 
    AA935411 BQ299730 BI051201 BQ359521 N99485 BI024174 BI005697 BE313988 
    N90698 AA632627 BG945658 AI569370 N20095 AA557768 BI005238 N39292 
    BF095728 BF840773 BI021793 BE748286 AA190547 BQ359520 BQ299728 BI005217 
    BQ299741 AW801113 BI001152 BQ329250 BM888279 BQ322766 AW516719 BG285593 
    AU099916 BG945659 BG945676 BF353220 BG992681 BQ299731 BG945639 BG878503 
    BE930937 AI702373 BQ299734 H67874 BG945648 BG945651 BG945661 BG945672 
    BG952520 BG314797 BG952141 BQ299742 BI004638 AI123275 BG945670 BQ373068 
    BG945635 BG483645 BG945664 CD707551 BG105457 AA729917 BQ439617 BQ378720 
    BG945646 BQ299719 BG945671 BQ187260 AI264463 BG981014 BI910344 AI749940 
    BG945662 BQ299718 BQ299710 BG959437 BM310634 BQ356035 AI860540 BF830215 
    BF174149 BG996077 BU536969 AA933701 BI005225 BM850008 BF734141 AA844255 
    AV752868 BG981973 BQ299746 BU953435 BG959430 BI042678 BE905993 BQ360990 
    BI002634 BE930948 BQ378355 AI933241 BE905919 BG008932 BG959791 AI369903 
    AV701703 BI042677 BG981509 BQ299721 BG283309 BI021791 BQ378428 BE408617 
    AI075108 AW389250 BG981976 AI698515 H82596 W24865 AW272962 BF971263 
    AI819243 BF095688 BQ379442 BF525883 BQ299729 AA337055 AV704674 BG566296 
    BG950498 AI918484 BU194312 AA057792 AI869898 BI051192 F00911 BE772839 
    BG170377 BF909589 BQ299720 BG327996 BG996222 W07016 BI004636 BG953638 
    AI865178 BQ319723 BG959804 BI051180 AI003622 AI186758 BF961272 CD705659 
    BF678473 BG996228 BE838119 BI051193 BG981472 BQ299739 AW518666 BG952137 
    BQ377515 BQ367683 BE786788 BF678818 BQ060022 BG959433 BF927777 BG328033 
    BF248227 BQ349888 BQ051668 BG475774 BG959823 BF752195 BI018560 BI051199 
    BQ304511 BG983815 R80575 W20111 AA216170 BI003841 BQ379481 BF908634 
    BG981085 BG983771 BG980717 AV703776 R82525 BG981031 BG993789 BI051203 
    BI042676 BG981089 BU602998 BG981653 BG980741 BG981073 BG983836 BG996130 
    BI050585 BG983813 BG980531 BQ379440 BF086452 BU956733 BG981488 BG980769 
    BG983781 BG983833 BG981038 AI185253 BG981083 BF313324 BI014386 BG981071 
    BG983729 AA903801 BG983832 BI021780 BQ326431 BG981092 BE930896 BF127542 
    BF858997 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                                -                     
    SP2:                    -           -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for PPIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIB expression in normal human tissues (normalized intensities)      PPIB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCACTTT
    PPIB Expression
    About this image


    PPIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Endochondral Facial Bones
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
             sensory organ/ear/inner ear   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             sensory organ/ear/inner ear   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             skeleton/cranium/chondrocranium   
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See PPIB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIB

    SOURCE GeneReport for Unigene cluster: Hs.434937
        SABiosciences Custom PCR Arrays for PPIB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPIB
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPIB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIB gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppib1 , 5 peptidylprolyl isomerase B1, 5 90.12(n)1
    93.98(a)1
      9 (35.69 cM)5
    190351  NM_011149.21  NP_035279.21 
     660601695 
    chicken
    (Gallus gallus)
    Aves PPIB1 peptidylprolyl isomerase B (cyclophilin B) 80.84(n)
    86.47(a)
      396447  NM_205461.1  NP_990792.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPIB6
    Peptidyl-prolyl cis-trans isomerase
    83(a)
    1 ↔ 1
    GL343490.1(417575-422070)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppib-prov2 peptidylprolyl isomerase B 76.63(n)    BC054168.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97f082 Danio rerio cDNA clone MGC73214 IMAGE4790964, complete more 79.36(n)    BC059560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28521 , 3 peptidyl-prolyl cis-trans isomerase3
    CG28521
    73(a)
    (best of 2)3
    68.17(n)1
    67.5(a)1
      58F33
    375911  NM_137851.31  NP_611695.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-53
    cyn-51
    cyclophillin3
    Protein CYN-51
    71(a)
    (best of 4)3
    63.35(n)1
    67.66(a)1
      I(15048595-15049564)3
    1733741  NM_061223.41  NP_493624.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR5(YDR304C)4
    CPR51
    Peptidyl-prolyl cis-trans isomerase (cyclophilin) of more4
    Cpr5p1
    55.85(n)1
    56.38(a)1
      4(1072557-1071880)4
    8518981, 4  NP_010590.31  NP_010590.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G559201 peptidyl-prolyl cis-trans isomerase 61.62(n)
    65.45(a)
      824758  NM_115450.3  NP_567029.1 
    rice
    (Oryza sativa)
    Liliopsida AK104772.12   -- 75.26(n)    AK104772.1 


    ENSEMBL Gene Tree for PPIB (if available)
    TreeFam Gene Tree for PPIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIB gene
    PPIH2  PPIC2  CWC272  PPWD12  PPIL42  PPIL22  PPIL32  PPIL12  
    18/23 SIMAP similar genes for PPIB using alignment to 1 protein entry:     PPIB_HUMAN(see all similar genes):
    PPIC    PPIA    PPIE    PPIH    LOC402252    RANBP2
    PPIL1    PPIF    PPID    PPIAL4A    PPIAL4B    PPIAL4C
    PPIAL4D    PPIAL4G    PPIG    NKTR    PPWD1    PPIL3

    PPIB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 SNPs in PPIB are shown (see all 241)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0634364
    Osteogenesis imperfecta 9 (OI9)4--see VAR_0634362 M R mis40--------
    rs1214345591,2
    Cpathogenic144510211(-) GCTCCC/TAGTTC 2 Q * stg10--------
    rs1378538641,2
    Cpathogenic144516370(-) CAACAG/TGAAGG 2 R M mis10--------
    rs287201931,2
    Cuntested144510170(-) GATGGC/GAAGCA 2 G syn15Minor allele frequency- G:0.00NS 188
    rs23072471,2
    C,F,Huntested144513532(-) TTCACC/TAGGGG 2 T syn1 ese312Minor allele frequency- T:0.01NA NS EU 6725
    rs115585951,2,4
    C,F,Huntested144515521(-) GCCGGG/TTGATC 2 V L mis1 ese39Minor allele frequency- T:0.00NS EA NA 762
    rs49041,2
    C,F,Huntested144516333(-) GGGTCC/AGTCTT 2 /S syn1 ese318Minor allele frequency- A:0.02MN EA NS WA NA EU 7035
    rs1818487441,2
    --44508805(+) GTCAGC/GTGGGT 1 -- ds50010--------
    rs38967871,2
    H--44508952(+) ATTTAG/AAGGTA 1 -- ds50015Minor allele frequency- A:0.00MN NS EA 562
    rs1864578931,2
    --44508983(+) ACATCA/CCTTAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PPIB (64448011 - 64455404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPIB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833036CNV Loss17160897
    nsv827360CNV Loss20364138


    Human Gene Mutation Database (HGMD): PPIB

    Locus Specific Mutation Databases (LSDB): PPIB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIB
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123841   
    OMIM disorders: 259440  
    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
  • Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue
    disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma.
    Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality.
    Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing
    loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 19 diseases for PPIB:    About MalaCards
    ppib-related osteogenesis imperfecta    osteogenesis imperfecta type 9    dyggve-melchior-clausen syndrome    osteogenesis imperfecta
    syphilis    dentinogenesis imperfecta    dwarfism    connective tissue disease
    nephrotic syndrome    encephalitis    multiple myeloma    myeloma
    hepatitis c    b-cell lymphomas    hepatocellular carcinoma    pancreatic cancer
    hepatitis    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for PPIB:
    Osteogenesis imperfecta

    PPIB for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPIB
    Human Genome Epidemiology (HuGE) Navigator: PPIB (1 document)

    Export disorders for PPIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIB gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with PPIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PubMed id 2000394)1, 2, 3, 9 Price E.R....Walsh C.T. (1991)
    2. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PubMed id 20089953)1, 2, 3, 9 Barnes A.M....Marini J.C. (2010)
    3. PPIB mutations cause severe osteogenesis imperfecta. (PubMed id 19781681)1, 2, 9 van Dijk F.S.... Pals G. (2009)
    4. A novel secreted cyclophilin-like protein (SCYLP). (PubMed id 2040592)1, 2, 9 Spik G.... Movva N.R. (1991)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. (PubMed id 8197205)1, 2 Mikol V.... Walkinshaw M.D. (1994)
    8. S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. (PubMed id 1530944)1, 2 Arber S.... Caroni P. (1992)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    10. An endoplasmic reticulum-specific cyclophilin. (PubMed id 1710767)1, 2 Hasel K.W.... Sutcliffe J.G. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5479 HGNC: 9255 AceView: PPIB Ensembl:ENSG00000166794 euGenes: HUgn5479
    ECgene: PPIB H-InvDB: PPIB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppib/
    Osteogenesis imperfecta variant databasehttp://oi.gene.le.ac.uk/home.php?select_db=PPIB

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIB gene:
    Search GeneIP for patents involving PPIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Browse Proteins at Cloud-Clone Corp.
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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