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protein-coding   GIFtS: 75
GCID: GC15M064448

Peptidylprolyl Isomerase B (Cyclophilin B)

  See PPIB-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Peptidylprolyl Isomerase B (Cyclophilin B)1 2     EC 8
CYPB2 3 5     OI92 5
Rotamase B2 3     HEL-S-392
CYP-S12 3     Cyclophilin-Like Protein2
S-cyclophilin2 3     Epididymis Secretory Protein Li 392
SCYLP2 3     Peptidyl-Prolyl Cis-Trans Isomerase B2
PPIase B2 3     Cyclophilin B3

External Ids:    HGNC: 92551   Entrez Gene: 54792   Ensembl: ENSG000001667947   OMIM: 1238415   UniProtKB: P232843   

Export aliases for PPIB gene to outside databases

Previous GC identifiers: GC15M060234 GC15M057607 GC15M062026 GC15M062163 GC15M062235 GC15M041272

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIB Gene:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic
reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind
to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants
have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. (provided by
RefSeq, Oct 2009)

GeneCards Summary for PPIB Gene:
PPIB (peptidylprolyl isomerase B (cyclophilin B)) is a protein-coding gene. Diseases associated with PPIB include ppib-related osteogenesis imperfecta, and osteogenesis imperfecta type 9. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIB Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIB gene promoter:
         Bach1   AP-1   Tal-1   E47   AREB6   FAC1   Pax-3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIB promoter sequence
   Search Chromatin IP Primers for PPIB

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q21-q22

PPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064448:  view genomic region     (about GC identifiers)

64,448,011 bp from pter      End:
64,455,404 bp from pter
7,394 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase B precursor  
Size: 216 amino acids; 23743 Da
Subunit: Interacts with DYM
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAA52150.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for PPIB:
1CYN (3D)        3ICH (3D)        3ICI (3D)    
Secondary accessions: A8K534 Q6IBH5 Q9BVK5

Explore the universe of human proteins at neXtProt for PPIB: NX_P23284

Explore proteomics data for PPIB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67, Lys98, Lys131, Lys158, Lys165, Lys209
  • Glycosylation2 at Asn148
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIB (P23284) (see all 10)

    See PPIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000933.1  
    ENSEMBL proteins: 
    Reactome Protein details: P23284

    PPIB Human Recombinant Protein Products:

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    OriGene Purified Protein for PPIB
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    OriGene MassSpec for PPIB
    OriGene Custom Protein Services for PPIB
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    Novus Biologicals PPIB Proteins
    Novus Biologicals PPIB Lysate
    Sino Biological Recombinant Protein for PPIB
    Sino Biological Cell Lysate for PPIB
    ProSpec Recombinant Protein for PPIB
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for PPIB 

    antibodies-online proteins for PPIB (29 products) 

    antibodies-online peptides for PPIB

    Search GeneTex for Proteins for PPIB 

    PPIB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for PPIB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPIB
    antibodies-online antibodies for PPIB (78 products) 

    GeneTex Antibodies for PPIB:  
                        PPIB Antibodies

    PPIB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPIB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPIB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPIB 
    antibodies-online kits for PPIB (37 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P23284

    ProtoNet protein and cluster: P23284

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain

    Find genes that share domains with PPIB           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIB_HUMAN, P23284
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB

         Genatlas biochemistry entry for PPIB:
    peptidyl-propyl isomerase B

         Enzyme Number (IUBMB): EC 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity NAS2000394
    GO:0005515protein binding IPI15095401
    GO:0005518contributes to collagen binding ISS--
    GO:0032403protein complex binding ISS--
    GO:0042277peptide binding IEA--
    Find genes that share ontologies with PPIB           About GenesLikeMe

         3 GenomeRNAi human phenotypes for PPIB:
     Increased G1 DNA content  Increased HPV18 LCR reporter a  Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppib):
     growth/size/body  integument  mortality/aging  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with PPIB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppibtm1.1Rjb for PPIB

       genOway: Develop your customized and physiologically relevant rodent model for PPIB

        Taconic Biosciences Mouse Models for PPIB:  
                        TF0539 - Ppib

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for PPIB

    miRTarBase miRNAs that target PPIB:
    hsa-mir-301a-3p (MIRT044215), hsa-mir-92a-3p (MIRT049173), hsa-mir-1 (MIRT001347)

    Block miRNA regulation of human, mouse, rat PPIB using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidPPIB 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for PPIB
    Predesigned siRNA for gene silencing in human, mouse, rat PPIB

    OriGene clones in human, mouse for PPIB (see all 7)
    OriGene ORF clones in mouse, rat for PPIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
    Sino Biological Human cDNA Clone for PPIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
    Addgene plasmids for PPIB 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for PPIB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPIB 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-10148 VA4-10510 VA6-10509) for PPIB 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    PPIB_HUMAN, P23284: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    endoplasmic reticulum5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0032991macromolecular complex ISS--
    GO:0042470melanosome IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PPIB           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for PPIB About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Collagen formation0.75
    2RANK Signaling in Osteoclasts
    Apoptosis and survival APRIL and BAFF signaling0.39
    3Prolactin Signaling Pathway
    Prolactin Signaling Pathway0.39
    4Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    5Syndecan-1-mediated signaling events
    Syndecan-1-mediated signaling events

    Find genes that share SuperPaths with PPIB           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 GeneGo (Thomson Reuters) Pathway for PPIB
        Apoptosis and survival APRIL and BAFF signaling

    2 BioSystems Pathways for PPIB
        Prolactin Signaling Pathway
    Syndecan-1-mediated signaling events

    1 Reactome Pathway for PPIB
        Collagen biosynthesis and modifying enzymes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIB

        GeneGlobe Interaction Network for PPIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPIB (P232841, 2, 3 ENSP000003000264) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF1Q130772, 3MINT-49520 I2D: score=2 
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization ISS--
    GO:0006457protein folding ----
    GO:0030198extracellular matrix organization TAS--
    GO:0040018positive regulation of multicellular organism growth IMP--
    GO:0050821protein stabilization IMP--

    Find genes that share ontologies with PPIB           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIB

    1 HMDB Compound for PPIB    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    2 DrugBank Compounds for PPIB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3targetbinder17139284 11752352 17016423
    1,4-Dithiothreitol-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PPIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclosporin a 69.9 42 9378502 (4), 10386979 (4), 8713086 (3), 11955071 (2) (see all 19)
    heparan sulfate 56.2 21 19940140 (4), 17588944 (4), 15109301 (4)
    proline 38.6 5 19781681 (2), 17630507 (1)
    anti-fungal 24.4 3 15245883 (1), 11848297 (1), 11732686 (1)
    heparin 22.8 6 15109301 (4), 19940140 (1)

    Find genes that share compounds with PPIB           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for PPIB gene: 

    Unigene Cluster for PPIB:

    Peptidylprolyl isomerase B (cyclophilin B)
    Hs.434937  [show with all ESTs]
    Unigene Representative Sequence: BQ049986
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300026(uc002and.3) ENST00000558492 ENST00000561048(uc010bgx.1)

    Block miRNA regulation of human, mouse, rat PPIB using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidPPIB 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for PPIB
    Predesigned siRNA for gene silencing in human, mouse, rat PPIB
    OriGene clones in human, mouse for PPIB (see all 7)
    OriGene ORF clones in mouse, rat for PPIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
    Addgene plasmids for PPIB 
    OriGene qPCR primer pairs and template standards for PPIB
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIB
      QuantiTect SYBR Green Assays in human, mouse, rat PPIB
      QuantiFast Probe-based Assays in human, mouse, rat PPIB
    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-10148 VA4-10510 VA6-10509) for PPIB 

    Additional mRNA sequence: 

    AK291149.1 AK311074.1 BC001125.2 BC008848.2 BC020800.1 BC032138.2 CR456829.1 M60457.1 
    M60857.1 M63573.1 

    Selected DOTS entries (see all 27):

    DT.95344633  DT.119195  DT.100845917  DT.95352178  DT.100845915  DT.100845910  DT.95352206  DT.97784070 
    DT.100845912  DT.100845913  DT.100845919  DT.121023162  DT.121023414  DT.92068163  DT.92457228  DT.95237355 
    DT.95352171  DT.100845914  DT.121023234  DT.121023413  DT.121023420  DT.92457220  DT.95147920  DT.95352090 

    Selected AceView cDNA sequences (see all 953):

    AW069876 BM461482 BC001125 BM826368 BU849690 BU077971 CA865787 BI768795 
    BG291432 BQ020844 CN484237 BM831044 BM825346 H28029 BQ683403 CF527923 
    BM825696 BM772843 BM830826 BM272656 BE907521 BM832180 CB133821 BM831000 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                                -                     
    SP2:                    -           -                     

    ECgene alternative splicing isoforms for PPIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    PPIB Expression
    About this image

    PPIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     Pancreas (Endocrine System)
             Islets of Langerhans
    PPIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434937
        Custom PCR Arrays for PPIB
    OriGene qPCR primer pairs and template standards for PPIB
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIB
    QuantiTect SYBR Green Assays in human, mouse, rat PPIB
    QuantiFast Probe-based Assays in human, mouse, rat PPIB
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIB gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Ppib1 , 5 peptidylprolyl isomerase B1, 5 90.12(n)1
      9 (35.69 cM)5
    190351  NM_011149.21  NP_035279.21 
    (Gallus gallus)
    Aves PPIB1 peptidylprolyl isomerase B (cyclophilin B) 80.84(n)
      396447  NM_205461.1  NP_990792.1 
    (Anolis carolinensis)
    Reptilia PPIB6
    peptidylprolyl isomerase B (cyclophilin B)
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia ppib-prov2 peptidylprolyl isomerase B 76.63(n)    BC054168.1 
    (Danio rerio)
    Actinopterygii wufa97f082 Danio rerio cDNA clone MGC73214 IMAGE4790964, complete more 79.36(n)    BC059560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28521 , 3 peptidyl-prolyl cis-trans isomerase3
    (best of 2)3
    375911  NM_137851.31  NP_611695.11 
    (Caenorhabditis elegans)
    Secernentea cyp-53
    (best of 4)3
    1733741  NM_061223.51  NP_493624.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR5(YDR304C)4
    Peptidyl-prolyl cis-trans isomerase (cyclophilin) of more4
    8518981, 4  NP_010590.31  NP_010590.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP20-21 CYP20-2 62.13(n)
      831151  NM_001203370.1  NP_001190299.1 
    (Oryza sativa)
    Liliopsida AK104772.12   -- 75.26(n)    AK104772.1 

    ENSEMBL Gene Tree for PPIB (if available)
    TreeFam Gene Tree for PPIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for PPIB gene
    PPIH2  PPIC2  CWC272  PPWD12  PPIL42  PPIL22  PPIL32  PPIL12  
    Selected SIMAP similar genes for PPIB using alignment to 1 protein entry:     PPIB_HUMAN(see all similar genes):
    PPIC    PPIA    PPIE    PPIH    LOC402252    RANBP2
    PPIAL4D    PPIAL4G    PPIG    NKTR    PPWD1    PPIL3

    Find genes that share paralogs with PPIB           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIB (see all 241)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 15 posSequence#AA
    Osteogenesis imperfecta 9 (OI9)4--see VAR_0634362 M R mis40--------
    Cpathogenic144510211(-) GCTCCC/TAGTTC 2 Q * stg10--------
    Cpathogenic144516370(-) CAACAG/TGAAGG 2 R M mis10--------
    Cuntested144510170(-) GATGGC/GAAGCA 2 G syn15Minor allele frequency- G:0.00NS 188
    C,F,Huntested144513532(-) TTCACC/TAGGGG 2 T syn1 ese312Minor allele frequency- T:0.01NA NS EU 6725
    C,F,Huntested144515521(-) GCCGGG/TTGATC 2 V L mis1 ese39Minor allele frequency- T:0.00NS EA NA 762
    C,F,Huntested144516333(-) GGGTCC/AGTCTT 2 /S syn1 ese318Minor allele frequency- A:0.02MN EA NS WA NA EU 7035
    --44508805(+) GTCAGC/GTGGGT 1 -- ds50010--------
    H--44508952(+) ATTTAG/AAGGTA 1 -- ds50015Minor allele frequency- A:0.00MN NS EA 562
    --44508983(+) ACATCA/CCTTAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PPIB (64448011 - 64455404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPIB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833036CNV Loss17160897
    nsv827360CNV Loss20364138

    Human Gene Mutation Database (HGMD): PPIB
    Locus Specific Mutation Databases (LSDB): PPIB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 123841   
    OMIM disorders: 259440  
    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
  • Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue
    disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma.
    Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality.
    Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing
    loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 8 diseases for PPIB:    
    About MalaCards
    ppib-related osteogenesis imperfecta    osteogenesis imperfecta type 9    osteogenesis imperfecta    dyggve-melchior-clausen syndrome
    japanese encephalitis    osteogenesis imperfecta, type ii    osteogenesis imperfecta type iii    osteogenesis imperfecta, type xv

    1 inferred disease relationship from the University of Copenhagen DISEASES database for PPIB:
    Osteogenesis imperfecta

    Find genes that share disorders with PPIB           About GenesLikeMe

    Genetic Association Database (GAD): PPIB
    Human Genome Epidemiology (HuGE) Navigator: PPIB (1 document)

    Export disorders for PPIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIB gene, integrated from 10 sources (see all 122) (see top 10):
    (articles sorted by number of sources associating them with PPIB)

    1. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PubMed id 2000394)1, 2, 3, 9 Price E.R....Walsh C.T. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PubMed id 20089953)1, 2, 3, 9 Barnes A.M....Marini J.C. (N. Engl. J. Med. 2010)
    3. PPIB mutations cause severe osteogenesis imperfecta. (PubMed id 19781681)1, 2, 9 van Dijk F.S.... Pals G. (Am. J. Hum. Genet. 2009)
    4. A novel secreted cyclophilin-like protein (SCYLP). (PubMed id 2040592)1, 2, 9 Spik G.... Movva N.R. (J. Biol. Chem. 1991)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. (PubMed id 8197205)1, 2 Mikol V.... Walkinshaw M.D. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    8. S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. (PubMed id 1530944)1, 2 Arber S.... Caroni P. (J. Cell Biol. 1992)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    10. An endoplasmic reticulum-specific cyclophilin. (PubMed id 1710767)1, 2 Hasel K.W.... Sutcliffe J.G. (Mol. Cell. Biol. 1991)
    11. Distribution of cyclophilin B-binding sites in the subsets of human peripheral blood lymphocytes. (PubMed id 9378502)1, 9 Denys A....Spik G. (Immunology 1997)
    12. The human TRPV6 channel protein is associated with cyclophilin B in human placenta. (PubMed id 18445599)1, 9 Stumpf T....Fecher-Trost C. (J. Biol. Chem. 2008)
    13. Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer. (PubMed id 19056847)1, 9 Fang F....Clevenger C.V. (Am. J. Pathol. 2009)
    14. Receptor type I and type II binding regions and the peptidyl-prolyl isomerase site of cyclophilin B are required for enhancement of T-lymphocyte adhesion to fibronectin. (PubMed id 11955071)1, 9 Carpentier M....Spik G. (Biochemistry 2002)
    15. Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies. (PubMed id 7829860)1, 9 Allain F....Spik G. (J. Immunol. Methods 1995)
    16. Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases. (PubMed id 19940140)1, 9 Deligny A....Allain F. (J. Biol. Chem. 2010)
    17. The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue. (PubMed id 17588944)1, 9 Vanpouille C....Allain F. (J. Biol. Chem. 2007)
    18. Characterization of surface binding sites for cyclophilin B on a human tumor T-cell line. (PubMed id 8206968)1, 9 Allain F....Spik G. (J. Biol. Chem. 1994)
    19. Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases. (PubMed id 18054915)1, 9 Melchior A....Allain F. (Exp. Cell Res. 2008)
    20. CD147 is a signaling receptor for cyclophilin B. (PubMed id 11688976)1, 9 Yurchenko V....Bukrinsky M. (Biochem. Biophys. Res. Commun. 2001)
    21. The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein. (PubMed id 9032343)1, 9 Braaten D....Luban J. (J. Virol. 1997)
    22. Cyclophilin B Supports Myc and Mutant p53-Dependent Survival of Glioblastoma Multiforme Cells. (PubMed id 24272483)1 Choi J.W....Bram R.J. (Cancer Res. 2014)
    23. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    24. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1A^cartilage-associated proteinA^cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. (PubMed id 24043621)1 Ishikawa Y. and BAochinger H.P. (J. Biol. Chem. 2013)
    25. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    26. Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. (PubMed id 22426501)1 Dieriks B. and Van Oostveldt P. (Int. J. Mol. Med. 2012)
    27. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    28. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. (PubMed id 23097496)1 Tyler R.E....Kopito R.R. (Mol. Biol. Cell 2012)
    29. Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat). (PubMed id 23144461)1 Hershko K....Kimchi-Sarfaty C. (J. Biol. Chem. 2012)
    30. Cyclophilin B attenuates the expression of TNF-I+ in lipopolysaccharide-stimulated macrophages through the induction of B cell lymphoma-3. (PubMed id 22798670)1 Marcant A....Allain F. (J. Immunol. 2012)
    31. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    32. Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. (PubMed id 22484812)1 Ray P....White R.R. (J. Clin. Invest. 2012)
    33. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    34. Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress. (PubMed id 22555451)1 Kim K....Choe W. (Apoptosis 2012)
    35. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    36. A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor. (PubMed id 22205628)1 Lorenson M.Y....Walker A.M. (Am. J. Physiol. Endocrinol. Metab. 2012)
    37. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    38. Involvement of cyclophilin B in the replication of Japanese encephalitis virus. (PubMed id 21281954)1 Kambara H....Matsuura Y. (Virology 2011)
    39. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    40. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    41. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    42. Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. (PubMed id 21257749)1 Bergeron M.J....Hediger M.A. (J. Biol. Chem. 2011)
    43. Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. (PubMed id 21956701)1 Akimov V....Blagoev B. (Mol Biosyst 2011)
    44. Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development. (PubMed id 21280149)2 Denais C....Machado R.D. (Hum. Mutat. 2011)
    45. Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes. (PubMed id 21282188)1 Pyott S.M....Byers P.H. (Hum. Mol. Genet. 2011)
    46. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    47. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    48. Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. (PubMed id 21559518)1 Morohashi K....Sugawara F. (PLoS ONE 2011)
    49. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    50. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
    51. Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans. (PubMed id 21748762)1 Kim Y....Kim S.S. (Hepatology 2011)
    52. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    53. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    54. Cyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells. (PubMed id 20237142)1 Fang F....Clevenger C.V. (J. Mol. Endocrinol. 2010)
    55. Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney. (PubMed id 21085665)1 SuA+Ac G....Meseguer A. (PLoS ONE 2010)
    56. Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain. (PubMed id 20801878)1 Kozlov G....Gehring K. (J. Biol. Chem. 2010)
    57. Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. (PubMed id 19297321)1 Hanoulle X....Lippens G. (J. Biol. Chem. 2009)
    58. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    59. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    60. Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. (PubMed id 19503092)1 Bauer K....Horn F. (Oncogene 2009)
    61. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    62. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    63. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. (PubMed id 17361185)1 Wilker E.W....Yaffe M.B. (Nature 2007)
    64. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    65. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PubMed id 17110338)1 Wang X....Balch W.E. (Cell 2006)
    66. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    67. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    68. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    69. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. (PubMed id 15989969)1 Watashi K....Shimotohno K. (Mol. Cell 2005)
    70. Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15952740)1 Ahmed M....Bergsten P. (J. Proteome Res. 2005)
    71. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S.... Mann M. (Nature 2005)
    72. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    73. Role of cyclophilin B in activation of interferon regulatory factor-3. (PubMed id 15764595)1 Obata Y....Matsuyama T. (J. Biol. Chem. 2005)
    74. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    75. Identification of FHOD1-binding proteins and mechanisms of FHOD1- regulated actin dynamics. (PubMed id 15095401)1 Westendorf J.J. and Koka S. (J. Cell. Biochem. 2004)
    76. Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor. (PubMed id 14729611)1 Schubert A. and Grimm S. (Cancer Res. 2004)
    77. Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. (PubMed id 12397072)1 Zhang J. and Herscovitz H. (J. Biol. Chem. 2003)
    78. Immunophilins and HIV-1 infection. (PubMed id 12181673)1 Minder D....Gehring H. (Arch. Virol. 2002)
    79. TTD: Therapeutic Target Database. (PubMed id 11752352)7 Chen X....Chen Y.Z. (Nucleic Acids Res. 2002)
    80. Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix. (PubMed id 11867726)1 Allain F....Spik G. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    81. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. (PubMed id 12475965)1 Meunier L.... Hendershot L.M. (Mol. Biol. Cell 2002)
    82. The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer. (PubMed id 11997457)1 Rycyzyn M.A. and Clevenger C.V. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    83. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    84. Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. (PubMed id 10935542)1 Rycyzyn M.A....Clevenger C.V. (Mol. Endocrinol. 2000)
    85. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    86. Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24. (PubMed id 10096576)1 Bristow R....Duncan J. (J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1999)
    87. Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain. (PubMed id 10026140)1 Endrich M.M....Gehring H. (J. Biol. Chem. 1999)
    88. The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-affinity ligand for immunophilins present in human blood. (PubMed id 9546659)1 Endrich M.M. and Gehring H. (Eur. J. Biochem. 1998)
    89. Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis. (PubMed id 9045699)1 Montague J.W....Cidlowski J.A. (J. Biol. Chem. 1997)
    90. Construction of a human full-length cDNA bank. (PubMed id 7821789)1 Kato S....Aoki T. (Gene 1994)
    91. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. (PubMed id 7522304)1 Bram R.J. and Crabtree G.R. (Nature 1994)
    92. Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. (PubMed id 7909608)1 Price E.R....McKeon F.D. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    93. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. (PubMed id 8513493)1 Luban J.... Goff S.P. (Cell 1993)
    94. Somatic cell mapping of the human cyclophilin B gene (PPIB) to chromosome 15. (PubMed id 1505219)1 Peddada L.B....Deans R.J. (Cytogenet. Cell Genet. 1992)
    95. Evidence that human milk isolated cyclophilin B corresponds to a truncated form. (PubMed id 8652625)9 Mariller C....Spik G. (Biochim. Biophys. Acta 1996)
    96. Octasaccharide is the minimal length unit required for efficient binding of cyclophilin B to heparin and cell surface heparan sulphate. (PubMed id 15109301)9 Vanpouille C....Allain F. (Biochem. J. 2004)
    97. Receptor-mediated transcytosis of cyclophilin B through the blood-brain barrier. (PubMed id 10386979)9 Carpentier M....Spik G. (J. Neurochem. 1999)
    98. Enhancing the effect of secreted cyclophilin B on immunosuppressive activity of cyclosporine. (PubMed id 9583869)9 Denys A....Spik G. (Transplantation 1998)
    99. Cyclophilin B binding to platelets supports calcium-dependent adhesion to collagen. (PubMed id 10419889)9 Allain F....Spik G. (Blood 1999)
    100. Hsp47 and cyclophilin B traverse the endoplasmic reticulum with procollagen into pre-Golgi intermediate vesicles. A role for Hsp47 and cyclophilin B in the export of procollagen from the endoplasmic reticulum. (PubMed id 7629154)9 Smith T....Sauk J.J. (J. Biol. Chem. 1995)
    101. Severe osteogenesis imperfecta in cyclophilin B-deficient mice. (PubMed id 19997487)9 Choi J.W....Bram R.J. (PLoS Genet. 2009)
    102. Involvement of the N-terminal part of cyclophilin B in the interaction with specific Jurkat T-cell binding sites. (PubMed id 8713087)9 Mariller C....Spik G. (Biochem. J. 1996)
    103. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. (PubMed id 18946027)9 Kim J....Kim S.S. (J. Cell. Sci. 2008)
    104. Target cell cyclophilins facilitate human papillomavirus type 16 infection. (PubMed id 19629175)9 Bienkowska-Haba M....Sapp M. (PLoS Pathog. 2009)
    105. Cyclophilin B mediates cyclosporin A incorporation in human blood T-lymphocytes through the specific binding of complexed drug to the cell surface. (PubMed id 8713086)9 Allain F....Spik G. (Biochem. J. 1996)
    106. Basic fibroblast growth factor induces 3T3 fibroblasts to synthesize and secrete a cyclophilin-like protein and beta 2-microglobulin. (PubMed id 1932134)9 Davis T.R....Nilsen-Hamilton M. (Biochim. Biophys. Acta 1991)
    107. Recessive osteogenesis imperfecta caused by LEPRE1 mutations: clinical documentation and identification of the splice form responsible for prolyl 3-hydroxylation. (PubMed id 19088120)9 Willaert A....De Paepe A. (J. Med. Genet. 2009)
    108. Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis. (PubMed id 17267519)9 Pakula R....Allain F. (Glycobiology 2007)
    109. Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete. (PubMed id 9317025)9 Shevchenko D.V....Radolf J.D. (Infect. Immun. 1997)
    110. Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex. (PubMed id 19846465)9 Chang W....Marini J.C. (Hum. Mol. Genet. 2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5479 HGNC: 9255 AceView: PPIB Ensembl:ENSG00000166794 euGenes: HUgn5479
    ECgene: PPIB H-InvDB: PPIB

    (According to HUGE)
    About This Section

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    PharmGKB entry for PPIB Pharmacogenomics, SNPs, Pathways
    Osteogenesis imperfecta variant database

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIB gene:
    Search GeneIP for patents involving PPIB

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway and/or Taconic Biosciences,
    CRISPR knockouts from OriGene)
    About This Section

     EMD Millipore genomic analysis products

     Antibodies for PPIB (Cyclophilin B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PPIB  
     OriGene qPCR primer pairs and template standards for PPIB   OriGene Protein Over-expression Lysate for PPIB  
     OriGene MassSpec for PPIB   OriGene clones in human, mouse for PPIB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPIB   OriGene Purified Protein for PPIB  
     OriGene ORF clones in mouse, rat for PPIB   OriGene CRISPR knockouts for PPIB
     OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling   OriGene Custom Antibody Services for PPIB  
     OriGene Custom Protein Services for PPIB  

     Block miRNA regulation of human, mouse, rat PPIB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPIB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIB Predesigned siRNA for gene silencing in human, mouse, rat PPIB
     QuantiFast Probe-based Assays in human, mouse, rat PPIB QuantiTect SYBR Green Assays in human, mouse, rat PPIB
     Custom PCR Arrays for PPIB Search Chromatin IP Primers for PPIB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIB  GeneGlobe Interaction Network for PPIB
     Regulatory tfbs in PPIB promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPIB GenScript cDNA clones with any tag delivered in your preferred vector for PPIB
     GenScript Custom Assay Services for PPIB GenScript Custom overexpressing Cell Line Services for PPIB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PPIB
     Proteins for PPIB
     Cell Lysates for PPIB
     cDNA Clones for PPIB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPIB antibodies
     PPIB proteins
     PPIB lysates
     Antibodies for PPIB
     See all of Abcam's Antibodies, Kits and Proteins for PPIB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PPIB
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.

     Browse ESI BIO Cell Lines and PureStem Progenitors for PPIB
     Selected Taconic Biosciences Mouse Models for PPIB:
    TF0539 - Ppib
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB
     SwitchGear 3'UTR luciferase reporter plasmids for PPIB
     SwitchGear Promoter luciferase reporter plasmids for PPIB
     ThermoFisher Antibody for PPIB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
     Browse compounds at ApexBio
     Addgene plasmids for PPIB
      Search eBioscience for proteins for PPIB
      Search eBioscience for elisas for PPIB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PPIB
     antibodies-online antibodies for PPIB (78 products)
     antibodies-online kits for PPIB (37 products)
     antibodies-online peptides for PPIB
     antibodies-online proteins for PPIB (29 products)
      GeneTex Antibodies for PPIB: PPIB Antibodies
      Search GeneTex for Proteins for PPIB
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