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Aliases for PPIB Gene

Aliases for PPIB Gene

  • Peptidylprolyl Isomerase B 2 3
  • Peptidylprolyl Isomerase B (Cyclophilin B) 3 5
  • Cyclophilin B 2 4
  • S-Cyclophilin 3 4
  • Rotamase B 3 4
  • EC 4 63
  • PPIase B 3 4
  • CYP-S1 3 4
  • SCYLP 3 4
  • CYPB 3 4
  • Epididymis Secretory Protein Li 39 3
  • Cyclophilin-Like Protein 3
  • HEL-S-39 3
  • OI9 3

External Ids for PPIB Gene

Previous GeneCards Identifiers for PPIB Gene

  • GC15M060234
  • GC15M057607
  • GC15M062026
  • GC15M062163
  • GC15M062235
  • GC15M064448
  • GC15M041272

Summaries for PPIB Gene

Entrez Gene Summary for PPIB Gene

  • The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

GeneCards Summary for PPIB Gene

PPIB (Peptidylprolyl Isomerase B) is a Protein Coding gene. Diseases associated with PPIB include Osteogenesis Imperfecta, Type Ix and Osteogenesis Imperfecta, Type Iii. Among its related pathways are Syndecan-1-mediated signaling events and Prolactin Signaling Pathway. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is PPIL2.

UniProtKB/Swiss-Prot for PPIB Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIB Gene

Genomics for PPIB Gene

Regulatory Elements for PPIB Gene

Enhancers for PPIB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIB on UCSC Golden Path with GeneCards custom track

Promoters for PPIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIB on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIB Gene

64,155,812 bp from pter
64,163,205 bp from pter
7,394 bases
Minus strand

Genomic View for PPIB Gene

Genes around PPIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIB Gene

Proteins for PPIB Gene

  • Protein details for PPIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase B
    Protein Accession:
    Secondary Accessions:
    • A8K534
    • Q6IBH5
    • Q9BVK5

    Protein attributes for PPIB Gene

    216 amino acids
    Molecular mass:
    23743 Da
    Quaternary structure:
    • Interacts with DYM. Interacts with CALR, CLGN and CANX.
    • Sequence=AAA52150.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPIB Gene

neXtProt entry for PPIB Gene

Proteomics data for PPIB Gene at MOPED

Selected DME Specific Peptides for PPIB Gene

Post-translational modifications for PPIB Gene

  • Ubiquitination at Lys 67, Lys 98, Lys 131, Lys 158, Lys 165, and Lys 209
  • Glycosylation at Asn 148
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPIB (PPIB)

Domains & Families for PPIB Gene

Gene Families for PPIB Gene

Suggested Antigen Peptide Sequences for PPIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
genes like me logo Genes that share domains with PPIB: view

Function for PPIB Gene

Molecular function for PPIB Gene

GENATLAS Biochemistry:
peptidyl-propyl isomerase B
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cyclosporin A (CsA) inhibits CYPB.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIB Gene

Gene Ontology (GO) - Molecular Function for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15095401
GO:0042277 peptide binding IEA --
GO:0070063 RNA polymerase binding IPI 15989969
genes like me logo Genes that share ontologies with PPIB: view
genes like me logo Genes that share phenotypes with PPIB: view

Human Phenotype Ontology for PPIB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPIB Gene

MGI Knock Outs for PPIB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIB

No data available for Transcription Factor Targets and HOMER Transcription for PPIB Gene

Localization for PPIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIB Gene

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269 PubMed:17081065}.

Subcellular locations from

Jensen Localization Image for PPIB Gene COMPARTMENTS Subcellular localization image for PPIB gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0042470 melanosome IEA --
GO:0048471 perinuclear region of cytoplasm IDA 15989969
genes like me logo Genes that share ontologies with PPIB: view

Pathways & Interactions for PPIB Gene

genes like me logo Genes that share pathways with PPIB: view

Pathways by source for PPIB Gene

Gene Ontology (GO) - Biological Process for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization ISS --
GO:0040018 positive regulation of multicellular organism growth IMP 20089953
GO:0060348 bone development IMP 20089953
genes like me logo Genes that share ontologies with PPIB: view

No data available for SIGNOR curated interactions for PPIB Gene

Drugs & Compounds for PPIB Gene

(5) Drugs for PPIB Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target, binder 0
1,4-Dithiothreitol Experimental Pharma Target 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPIB Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
genes like me logo Genes that share compounds with PPIB: view

Transcripts for PPIB Gene

mRNA/cDNA for PPIB Gene

Unigene Clusters for PPIB Gene

Peptidylprolyl isomerase B (cyclophilin B):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for PPIB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIB Gene

mRNA expression in normal human tissues for PPIB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIB Gene

SOURCE GeneReport for Unigene cluster for PPIB Gene Hs.434937

genes like me logo Genes that share expression patterns with PPIB: view

Protein tissue co-expression partners for PPIB Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIB Gene

Orthologs for PPIB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPIB 35
  • 90.22 (n)
  • 93.75 (a)
  • 94 (a)
(Canis familiaris)
Mammalia PPIB 35
  • 90.59 (n)
  • 95.83 (a)
  • 96 (a)
(Mus musculus)
Mammalia Ppib 35
  • 90.12 (n)
  • 93.98 (a)
Ppib 16
Ppib 36
  • 94 (a)
(Pan troglodytes)
Mammalia PPIB 35
  • 99.85 (n)
  • 99.54 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppib 35
  • 89.1 (n)
  • 93.27 (a)
(Monodelphis domestica)
Mammalia PPIB 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PPIB 36
  • 89 (a)
(Gallus gallus)
Aves PPIB 35
  • 80.84 (n)
  • 86.47 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia PPIB 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppib 35
  • 76.76 (n)
  • 87.5 (a)
Str.806 35
African clawed frog
(Xenopus laevis)
Amphibia ppib-prov 35
(Danio rerio)
Actinopterygii ppib 35
  • 76.08 (n)
  • 81.02 (a)
wufa97f08 35
ppib 36
  • 82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8306 35
fruit fly
(Drosophila melanogaster)
Insecta CG2852 37
  • 73 (a)
ninaA 37
  • 52 (a)
CG2852 35
  • 68.17 (n)
  • 67.5 (a)
CG2852 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007088 35
  • 65.62 (n)
  • 70.68 (a)
(Caenorhabditis elegans)
Secernentea cyp-3 37
  • 62 (a)
cyp-5 37
  • 71 (a)
cyp-6 37
  • 69 (a)
cyp-8 37
  • 52 (a)
cyn-5 35
  • 63.35 (n)
  • 67.66 (a)
cyn-5 36
  • 66 (a)
cyn-6 36
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL056C 35
  • 58.28 (n)
  • 60.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10208g 35
  • 58.09 (n)
  • 60.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR5 35
  • 55.56 (n)
  • 56.08 (a)
CPR2 36
  • 50 (a)
CPR5 36
  • 47 (a)
CPR5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP20-2 35
  • 62.13 (n)
  • 65.09 (a)
(Oryza sativa)
Liliopsida Os05g0103200 35
  • 63.04 (n)
  • 63.21 (a)
(Triticum aestivum)
Liliopsida Ta.28895 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01200 35
  • 65.46 (n)
  • 67.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp4 35
  • 61.29 (n)
  • 67.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5529 36
  • 71 (a)
Species with no ortholog for PPIB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIB Gene

Gene Tree for PPIB (if available)
Gene Tree for PPIB (if available)

Paralogs for PPIB Gene

Paralogs for PPIB Gene

(23) SIMAP similar genes for PPIB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIB: view

Variants for PPIB Gene

Sequence variations from dbSNP and Humsavar for PPIB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11558595 - 64,162,112(+) GCCGG(A/C/G/T)TGATC reference, missense
VAR_063436 Osteogenesis imperfecta 9 (OI9)
rs4904 -- 64,162,924(-) GGGTC(A/C/T)GTCTT reference, synonymous-codon
rs7182032 -- 64,164,156(+) GTAGT(C/G)TTCAT upstream-variant-2KB
rs7182202 -- 64,164,236(+) TTACA(C/T)AGGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPIB Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
nsv827360 CNV Loss 20364138

Variation tolerance for PPIB Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIB Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIB Gene

Disorders for PPIB Gene

MalaCards: The human disease database

(10) MalaCards diseases for PPIB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PPIB in MalaCards View complete list of genes associated with diseases


  • Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. {ECO:0000269 PubMed:19781681, ECO:0000269 PubMed:20089953}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PPIB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPIB: view

No data available for Genatlas for PPIB Gene

Publications for PPIB Gene

  1. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PMID: 2000394) Price E.R. … Walsh C.T. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23 67
  2. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PMID: 20089953) Barnes A.M. … Marini J.C. (N. Engl. J. Med. 2010) 2 3 23
  3. Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases. (PMID: 19940140) Deligny A. … Allain F. (J. Biol. Chem. 2010) 3 23
  4. Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer. (PMID: 19056847) Fang F. … Clevenger C.V. (Am. J. Pathol. 2009) 3 23
  5. PPIB mutations cause severe osteogenesis imperfecta. (PMID: 19781681) van Dijk F.S. … Pals G. (Am. J. Hum. Genet. 2009) 3 23

Products for PPIB Gene

Sources for PPIB Gene